An anonymous reader writes: The mysterious ways cancer spreads through the body, a process known as metastasis, is what can make it such a difficult enemy to keep at bay. Researchers at Princeton University working in this area have been tugging at a particular thread for more than 15 years, focusing on a single gene central to the ability of most major cancers to metastasize. They've now discovered what they describe as a "silver bullet" in the form of a compound that can disable this gene in mice and human tissue, with clinical trials possibly not too far away.

This discovery has its roots in 2004 research in which Princeton scientists identified a gene implicated in metastatic breast cancer, called metadherin, or MTDH. A 2009 paper by cancer biologist Yibin Kang then showed the gene was amplified and produced abnormally high levels of MTDH proteins in around a third of breast cancer tumors, and was central to not just the process of metastasis, but also the resistance of those tumors to chemotherapy. Subsequent research continued to shed light on the importance of the MTDH gene, demonstrating how it is critical for cancer to flourish and metastasize. Mice engineered to lack the gene grew normally, and those that did get breast cancer featured far fewer tumors -- and those tumors that did form didn't metastasize. This was then found to be true of prostate cancer, lung cancer, colorectal cancer, liver cancer and many other cancers.

The crystal structure of MTDH shows the protein has a pair of protrusions likened to fingers, which interlock with two holes in the surface of another protein called SND1. This is "like two fingers sticking into the holes of a bowling ball," according to Kang, and the scientists suspected if this intimate connection could be broken, it could go a long way to dampening the harmful effects of MTDH. "We knew from the crystal structure what the shape of the keyhole was, so we kept looking until we found the key," Kang says. The team spent two years screening for the right molecules to fill these holes without any great success, until they landed on what they say is a "silver bullet." The resulting compound plugs these voids and prevents the proteins from interlocking, with profound anti-cancer effects that resemble those seen in the MTDH-deficient mice from their earlier work. "The scientists say that MTDH assists cancer in two primary ways, by helping tumors endure the stresses of chemotherapy and by silencing the alarm that organs normally sound when a tumor invades them," adds New Atlas. "By interlocking with the SND1 protein, it prevents the immune system from recognizing the danger signals normally generated by cancerous cells, and therefore stops it from attacking them. The team is now working to refine the compound, hoping to improve its effectiveness in disrupting the connection between MTDH and SND1 and lower the required dosage. [T]hey hope to be ready for clinical trials on human patients in two to three years."

The research has been published across two papers in the journal Nature Cancer.

Nasa has postponed a planned spacewalk outside the International Space Station due to flying "debris," two weeks after Russia blew up one of its own satellites in a missile test that created clouds of zooming shrapnel in orbit. From a report: Washington's space agency did not mention the Russian test in its announcement, but a Nasa official had warned a day earlier of a slightly elevated risk to astronauts due to the 14 November incident. The strike generated thousands of pieces of "space junk" that are now hurling around the Earth at about 17,000 mph (27,400km/h) -- much faster than the speed of a bullet. At that velocity, even tiny flecks of paint can damage spacecraft, with spacesuits even more vulnerable.

On Tuesday, about five hours before the astronauts Thomas Marshburn and Kayla Barron were due to venture outside the space station, Nasa said on Twitter that the spacewalk to fix a failed antenna had been cancelled. "Nasa received a debris notification for the space station. Due to the lack of opportunity to properly assess the risk it could pose to the astronauts, teams have decided to delay the 30 November spacewalk until more information is available," it tweeted. Moscow has said its test to destroy its own spacecraft, Tselina-D, which had been in orbit since 1982, was successful and the debris posed no "threat to space activity."

The head of drugmaker Moderna said COVID-19 vaccines are unlikely to be as effective against the Omicron variant of the coronavirus as they have been previously, sparking fresh worry in financial markets about the trajectory of the pandemic. From a report: "There is no world, I think, where (the effectiveness) is the same level... we had with Delta," Moderna Chief Executive Stephane Bancel told the Financial Times in an interview. "I think it's going to be a material drop. I just don't know how much because we need to wait for the data. But all the scientists I've talked to are like 'this is not going to be good.'"

Vaccine resistance could lead to more sickness and hospitalisations and prolong the pandemic, and his comments triggered selling in growth-exposed assets like oil, stocks and the Australian dollar. Bancel added that the high number of mutations on the protein spike the virus uses to infect human cells meant it was likely the current crop of vaccines would need to be modified. He had earlier said on CNBC that it could take months to begin shipping a vaccine that does work against Omicron.

An anonymous reader quotes a report from Reuters: Rights groups petitioned Israel's top court on Monday to repeal new COVID-19 measures that authorize the country's domestic intelligence service to use counter-terrorism phone tracking technology to contain the spread of the Omicron virus variant. Announcing the emergency measures on Saturday, Prime Minister Naftali Bennett said the phone tracking would be used to locate carriers of the new and potentially more contagious variant in order to curb its transmission to others. Israeli rights groups say the emergency measures violate previous Supreme Court rulings over such surveillance, used on-and-off by the country's Shin Bet domestic intelligence agency since March, 2020.

A senior health ministry official said on Sunday that use of phone tracking would be "surgical" in nature, only to be utilized on confirmed or suspected carriers of the variant. The surveillance technology matches virus carriers' locations against other mobile phones nearby to determine with whom they have come into contact. Israel's Supreme Court this year limited the scope of its use after civil rights groups mounted challenges over privacy concerns. Further reading: Omicron Covid Variant Poses Very High Global Risk, Says WHO

The US scientists who created the first living robots say the life forms, known as xenobots, can now reproduce -- and in a way not seen in plants and animals. CNN reports: Formed from the stem cells of the African clawed frog (Xenopus laevis) from which it takes its name, xenobots are less than a millimeter (0.04 inches) wide. The tiny blobs were first unveiled in 2020 after experiments showed that they could move, work together in groups and self-heal. Now the scientists that developed them at the University of Vermont, Tufts University and Harvard University's Wyss Institute for Biologically Inspired Engineering said they have discovered an entirely new form of biological reproduction different from any animal or plant known to science.

[T]hey found that the xenobots, which were initially sphere-shaped and made from around 3,000 cells, could replicate. But it happened rarely and only in specific circumstances. The xenobots used "kinetic replication" -- a process that is known to occur at the molecular level but has never been observed before at the scale of whole cells or organisms [...]. With the help of artificial intelligence, the researchers then tested billions of body shapes to make the xenobots more effective at this type of replication. The supercomputer came up with a C-shape that resembled Pac-Man, the 1980s video game. They found it was able to find tiny stem cells in a petri dish, gather hundreds of them inside its mouth, and a few days later the bundle of cells became new xenobots.

The xenobots are very early technology -- think of a 1940s computer -- and don't yet have any practical applications. However, this combination of molecular biology and artificial intelligence could potentially be used in a host of tasks in the body and the environment, according to the researchers. This may include things like collecting microplastics in the oceans, inspecting root systems and regenerative medicine. While the prospect of self-replicating biotechnology could spark concern, the researchers said that the living machines were entirely contained in a lab and easily extinguished, as they are biodegradable and regulated by ethics experts. "Most people think of robots as made of metals and ceramics but it's not so much what a robot is made from but what it does, which is act on its own on behalf of people," said Josh Bongard, a computer science professor and robotics expert at the University of Vermont and lead author of the study, writing in the Proceedings of the National Academy of Sciences. "In that way it's a robot but it's also clearly an organism made from genetically unmodified frog cell."

"The AI didn't program these machines in the way we usually think about writing code. It shaped and sculpted and came up with this Pac-Man shape," Bongard said. "The shape is, in essence, the program. The shape influences how the xenobots behave to amplify this incredibly surprising process."

No one really knew why some patients with a white blood cell cancer called chronic lymphocytic leukemia, or C.L.L., relapsed after treatment and got a second cancer. Were some cancer cells just resistant? An unexpected answer to this mystery has been found using a new technique that researchers call bar coding: The treatment does not always target the right cells. From a report: Scientists discovered that the cancer does not always originate in the mature bone marrow cells where it is found and where textbooks say it originates. Instead, for some patients, the mother lode of the cancer can be primitive bone marrow cells, the stem cells, that give rise to all of the body's white and red blood cells. Those cells, not affected by the chemotherapy treatment, can spawn new cancer cells, causing a relapse. The discovery is one early fruit of the bar coding method, which is aiding the study of the origins of cancer and other diseases. The results are too new to have led to patient therapies. But they are leading to provocative discoveries that are expected to inspire novel methods for treating diseases.

The method works by marking individual cells with a stamp that is passed on to all of a cell's progeny. Researchers can look at a cell, note its bar code and trace its lineage back to its parents, grandparents, great-grandparents -- all the way back to its origins -- because each cell that arose from the original bar coded cell has the same stamp. The idea for bar coding during embryonic development originated with Dr. Jay Shendure and his colleagues at the University of Washington, and this class of methods was anointed the breakthrough of the year by Science magazine in 2018. Now there is a variety of methods for bar coding ranging from embryo cells to cancer cells to mature cells.

For example, Dr. Shendure and another group of colleagues at the University of Pennsylvania are using bar codes in mice with pancreatic cancer to study the spread of cancer cells in their bodies. In the case of C.L.L. above, Dr. Vijay Sankaran at Boston Children's Hospital and his colleagues bar coded human cancer cells by taking advantage of innocuous, naturally occurring mutations that mark individual cells and are inherited by their progeny. Bar coding, Dr. Sankaran said, "starts to give us a view of cancer that we never had before."

Researchers at the California Institute of Technology have developed "a kind of genetic toolbox" for tiny one-centimeter jellfyfish, reports Phys.org. Specifically, the jellyfish "have been genetically modified so that their neurons individually glow with fluorescent light when activated." Because a jellyfish is transparent, researchers can then watch the glow of the animal's neural activity as it behaves naturally. In other words, the team can read a jellyfish's mind as it feeds, swims, evades predators, and more, in order to understand how the animal's relatively simple brain coordinates its behaviors. A paper describing the new study appears in the journal Cell on November 24....

Rather than being centralized in one part of the body like our own brains, the jellyfish brain is diffused across the animal's entire body like a net. The various body parts of a jellyfish can operate seemingly autonomously, without centralized control; for example, a jellyfish mouth removed surgically can carry on "eating" even without the rest of the animal's body.

This decentralized body plan seems to be a highly successful evolutionary strategy, as jellyfish have persisted throughout the animal kingdom for hundreds of millions of years. But how does the decentralized jellyfish nervous system coordinate and orchestrate behaviors...? [T]hough the network of jellyfish neurons originally seemed diffuse and unstructured, the researchers found a surprising degree of organization that only became visible with their fluorescent system.
Ultimately the researchers say they've identified "patches" of neurons that work together, and they now want to study how various "modules" of neuron groups are coordinating.

"A team of researchers has finally created a long-sought locally testable code that can immediately betray whether it's been corrupted..." reports Quanta magazine.

"Many thought local testability would never be achieved in its ideal form." Now, in a preprint released on November 8, the computer scientist Irit Dinur of the Weizmann Institute of Science and four mathematicians, Shai Evra, Ron Livne, Alex Lubotzky and Shahar Mozes, all at the Hebrew University of Jerusalem, have found it. "It's one of the most remarkable phenomena that I know of in mathematics or computer science," said Tom Gur of the University of Warwick. "It's been the holy grail of an entire field."

Their new technique transforms a message into a super-canary, an object that testifies to its health better than any other message yet known. Any corruption of significance that is buried anywhere in its superstructure becomes apparent from simple tests at a few spots. "This is not something that seems plausible," said Madhu Sudan of Harvard University. "This result suddenly says you can do it."

Most prior methods for encoding data relied on randomness in some form. But for local testability, randomness could not help. Instead, the researchers had to devise a highly nonrandom graph structure entirely new to mathematics, which they based their new method on. It is both a theoretical curiosity and a practical advance in making information as resilient as possible....

To get a sense of what their graph looks like, imagine observing it from the inside, standing on a single edge. They construct their graph such that every edge has a fixed number of squares attached. Therefore, from your vantage point you'd feel as if you were looking out from the spine of a booklet. However, from the other three sides of the booklet's pages, you'd see the spines of new booklets branching from them as well. Booklets would keep branching out from each edge ad infinitum. "It's impossible to visualize. That's the whole point," said Lubotzky. "That's why it is so sophisticated...."

[A] test at one node can reveal information about errors from far away nodes. By making use of higher dimensions, the graph is ultimately connected in ways that go beyond what we typically even think of as connections... It establishes a new state of the art for error-correcting codes, and it also marks the first substantial payoff from bringing the mathematics of high-dimensional expanders to bear on codes...

Practical and theoretical applications should soon follow. Different forms of locally testable codes are now being used in decentralized finance, and an optimal version will allow even better decentralized tools.

Long-time Slashdot reader fahrbot-bot shares the New York Times' report on a 64-year-old man who participated in a clinical trial by Vertex Pharmaceuticals involving an infusion of insulin-producing pancreas cells grown from stem cells.

"Now his body automatically controls its insulin and blood sugar levels." Mr. Shelton, now 64, may be the first person cured of the disease with a new treatment that has experts daring to hope that help may be coming for many of the 1.5 million Americans suffering from Type 1 diabetes. "It's a whole new life," Mr. Shelton said. "It's like a miracle." Diabetes experts were astonished but urged caution.

The study is continuing and will take five years, involving 17 people with severe cases of Type 1 diabetes. It is not intended as a treatment for the more common Type 2 diabetes.

"We've been looking for something like this to happen literally for decades," said Dr. Irl Hirsch, a diabetes expert at the University of Washington who was not involved in the research. He wants to see the result, not yet published in a peer-reviewed journal, replicated in many more people. He also wants to know if there will be unanticipated adverse effects and if the cells will last for a lifetime or if the treatment would have to be repeated. But, he said, "bottom line, it is an amazing result...."

For Mr. Shelton the moment of truth came a few days after the procedure, when he left the hospital. He measured his blood sugar. It was perfect. He and Ms. Shelton had a meal. His blood sugar remained in the normal range.

Mr. Shelton wept when he saw the measurement.

"The only thing I can say is 'thank you.'"
15 people in a lab spent over 20 years working on converting the stem cells, the article reports. The total cost: about $50 million.

"It's one thing to produce nanoscale devices, but it's another to study and improve on them — they're so small they can't reflect enough light to get a good look," reports Engadget. "A breakthrough might make that possible, however." Univeristy of California Riverside researchers have built technology that squeezes tungsten lamp light into a 6-nanometer spot at the end of a silver nanowire. That lets scientists produce color imaging at an "unprecedented" level, rather than having to settle for molecular vibrations. The developers modified an existing "superfocusing" tool (already used to measure vibrations) to detect signals across the entire visible spectrum. Light travels in a flashlight-like conical path. When the nanowire's tip passes over an object, the system records that item's influence on the beam shape and color (including through a spectrometer). With two pieces of specrtra for every 6nm pixel, the team can create color photos of carbon nanotubes that would otherwise appear gray.
"The researchers expect that the new technology can be an important tool to help the semiconductor industry make uniform nanomaterials with consistent properties for use in electronic devices," according to an announcement from University of California Riverside, adding that the new full-color nano-imaging technique "could also be used to improve understanding of catalysis, quantum optics, and nanoelectronics."

Long-time Slashdot reader thisisnotreal writes: Long sought-after, and previously thought impossible — a McMaster University PhD student in Hamilton Canada demonstrates a cost-effective and simple laser in silicon.

This could have dramatic consequences for the SiP (Silicon Photonics) — a hot topic for those working in the field of integrated optics. Integrated optics is a critical technology involved in advanced telecommunications networks, and showing increasing importance in quantum research and devices, such as QKD (Quantum Key Distribution) and in various entanglement type experiments (involved in Quantum Compute).
"This is the holy grail of photonics," says Jonathan Bradley, an assistant professor in the Department of Engineering Physics (and the student's co-supervisor) in an announcement from McMaster University. "Fabricating a laser on silicon has been a longstanding challenge." Bradley notes that Miarabbas Kiani's achievement is remarkable not only for demonstrating a working laser on a silicon chip, but also for doing so in a simple, cost-effective way that's compatible with existing global manufacturing facilities. This compatibility is essential, as it allows for volume manufacturing at low cost. "If it costs too much, you can't mass produce it," says Bradley.

The Los Angeles Times summarizes the results of a new medical study conducted by Northwestern University researchers on antibody levels protecting against Covid-19 in 974 people. "Those who were immunized against COVID-19 with two doses of an mRNA vaccine and received a booster shot about eight months later saw their levels of neutralizing antibodies skyrocket.

"Among this group of 33 fully vaccinated and boosted people, the median level of these antibodies was 23 times higher one week after the booster shot than it had been just before the tune-up dose." What's more, their median post-booster antibody level was three times higher than was typical for another group of people whose antibodies were measured a few weeks after getting their second dose of vaccine, when they're close to their peak.

And it was 53 times higher than that of a group of 76 unvaccinated people who had recovered from COVID-19 just two to six weeks earlier. Even compared to a group of 73 people who had weathered a bout with COVID-19 and went on to get two doses of an mRNA vaccine, the boosted group's median antibody level was 68% higher.

Study leader Alexis Demonbreun, a cell biologist at Northwestern University's Feinberg School of Medicine, said the data demonstrate that no matter how well protected a vaccinated person may think she is, getting a booster shot is likely to increase her neutralizing antibodies — and with it, her immunity — considerably. And because scientists expect large antibody responses to create more durable immunity, the protection afforded by the booster should last longer than the initial two-shot regimen did...

Among their other findings: After receiving two doses of vaccine, people who'd already had an asymptomatic infection were typically no better protected than vaccinated people who had never been infected.

"The international Forward Search Experiment team, led by physicists at the University of California, Irvine, has achieved the first-ever detection of neutrino candidates produced by the Large Hadron Collider at the CERN facility near Geneva, Switzerland," reports Phys.org.

Long-time Slashdot reader fahrbot-bot shared their report: In a paper published Friday in the journal Physical Review D, the researchers describe how they observed six neutrino interactions during a pilot run of a compact emulsion detector installed at the LHC in 2018. "Prior to this project, no sign of neutrinos has ever been seen at a particle collider," said co-author Jonathan Feng, UCI Distinguished Professor of physics & astronomy and co-leader of the FASER Collaboration. "This significant breakthrough is a step toward developing a deeper understanding of these elusive particles and the role they play in the universe."

He said the discovery made during the pilot gave his team two crucial pieces of information. "First, it verified that the position [480 meters] forward of the ATLAS interaction point at the LHC is the right location for detecting collider neutrinos," Feng said. "Second, our efforts demonstrated the effectiveness of using an emulsion detector to observe these kinds of neutrino interactions...."

"Given the power of our new detector and its prime location at CERN, we expect to be able to record more than 10,000 neutrino interactions in the next run of the LHC, beginning in 2022," said co-author David Casper, FASER project co-leader and associate professor of physics & astronomy at UCI. "We will detect the highest-energy neutrinos that have ever been produced from a human-made source."
The article also points out that in future experiments the researchers hope to explore dark matter — and how it interacts with normal atoms.

While the Omicron mutation might "impact" the effectiveness of our current vaccines, they're "super unlikely" to render them useless, according to Dr. Ashish Jha, dean of Brown University's School of Public Health.

And USA Today reports that vaccine makers are already getting ready to fight the variant: Health experts have said it will likely be weeks before the world has good data about how omicron may reduce the effectiveness of current vaccines, but Moderna has already announced a three-point strategy to combat the new variant...

Moderna's strategy involves three options for boosting COVID-19 vaccination, should omicron prove problematic for current vaccines. The three options, according to a Friday release from the company: A higher dose booster, shots currently being studied that are designed to "anticipate mutations such as those that have emerged in the Omicron variant" and an omicron-specific booster — which is already in the works.

Andy Slavitt, who previously served as President Joe Biden's White House senior adviser for COVID response, said in a tweet that both Moderna and Pfizer-BioNTech have estimated a vaccine to combat a new variant could be developed in about 3 months, with some regulatory and logistical hurtles to follow. "If we start in early December, new vaccines could be available by summer in much of the world," Slavitt tweeted.

Multiple media organizations on Friday reported Pfizer-BioNTech is studying the new variant and expects data within weeks. If warranted, a targeted vaccine could be developed within 6 weeks and ship within 100 days, the reports say.

Johnson & Johnson is also testing its current vaccine against omicron, according to CNBC.

"The thought of combining a printer (the bane of office workers) with the bacterium E. coli (the scourge of romaine lettuce) may seem an odd, if not unpleasant, collaboration," writes the New York Times.

"But scientists have recently melded the virtues of the infuriating tool and of the toxic microbe to produce an ink that is alive, made entirely from microbes." The microbial ink flows like toothpaste under pressure and can be 3D-printed into various tiny shapes — a circle, a square and a cone — all of which hold their form and glisten like Jell-O. The researchers describe their recipe for their programmable, microbial ink in a study published on Tuesday in the journal Nature Communications.

The material is still being developed, but the authors suggest that the ink could be a crucial renewable building material, able to grow and heal itself and ideal for constructing sustainable homes on Earth and in space... [T]he new substance contains no additional polymers; it is produced entirely from genetically engineered E. coli bacteria. The researchers induce bacterial cultures to grow the ink, which is also made of living bacteria cells. When the ink is harvested from the liquid culture, it becomes firm like gelatin and can be plugged into 3D-printers and printed into living structures, which do not grow further and remain in their printed forms...

Bacteria may seem an unconventional building block. But microbes are a crucial component of products such as perfumes and vitamins, and scientists have already engineered microbes to produce biodegradable plastics. A material like a microbial ink has more grandiose ambitions, according to Neel Joshi, a synthetic biologist at Northeastern University and an author on the new paper. Such inks are an expanding focus of the field of engineered living materials. Unlike structures cast from concrete or plastic, living systems would be autonomous, adaptive to environmental cues and able to regenerate — at least, that is the aspirational goal, Dr. Joshi said. "Imagine creating buildings that heal themselves," said Sujit Datta, a chemical and biological engineer at Princeton University who was not involved with the research....

Dr. Manjula-Basavanna is shooting for the moon, Earth's satellite, where there are no forests to harvest for wood and no easy way to send bulk building materials. There, he said, the ink might be used as a self-regenerating substance to help build habitats on other planets, as well as places on Earth. "There is a lot of work to be done to make it scalable and economic," Dr. Datta conceded. But, he noted, just five years ago creating robust structures out of microbes was unimaginable; conceivably, self-healing buildings could be a reality in our lifetime.

The Biden administration announced plans on Friday to ban travel to the United States from South Africa and seven other countries, just hours after a new coronavirus variant was deemed a highly transmissible virus of concern. From a report: The travel restrictions will begin Monday, affecting South Africa, Botswana, Zimbabwe, Namibia, Lesotho, Eswatini, Mozambique and Malawi, according to a senior administration official. The administration's decision was in response to advice from Anthony Fauci, the president's chief medical adviser, and the Centers for Disease Control and Prevention, the official said. Roughly a dozen countries took similar action on Friday.

President Joe Biden, who is in Nantucket for the holiday, was briefed on the new variant Friday. He urged fully vaccinated Americans to get booster shots and the unvaccinated to get the "life-saving protection." Biden also addressed the global community in his statement, saying the new variant shows the pandemic won't end until vaccines are readily available around the world. He said the U.S. has donated more vaccines than every country combined, calling on others to match "America's speed and generosity."

The Einstein Foundation Berlin is honoring the American physicist Paul Ginsparg and the Center for Open Science with the inaugural Einstein Foundation Award for Promoting Quality in Research. Paul Ginsparg is the founder of the preprint server arXiv.org, the first platform to exchange scientific discoveries among scientists immediately, openly and globally without review- and paywall restrictions.

South Africa's government is considering new public-health restrictions to contain a fast-spreading new variant of the coronavirus that scientists say has a high number of mutations that may make it more transmissible and allow it to evade some of the immune responses triggered by previous infection or vaccination. From a report: The warning from the South African scientists and the Health Ministry, issued in a hastily called news briefing Thursday, prompted the World Health Organization to call a meeting of experts for Friday to discuss whether to declare the new strain a "variant of concern." The WHO uses this label for virus strains that have been proven to be more contagious, lead to more serious illness or decrease the effectiveness of public-health measures, tests, treatments or vaccines. Other variants of concern include the Delta variant that is now dominant world-wide and the Alpha variant that drove a deadly wave of infections across Europe and the U.S. last winter and spring. While the scientists said they were still studying the exact combination of mutations of the new variant -- currently dubbed B.1.1.529 -- and how they affect the virus, its discovery underlines how changes to the virus's genome continue to pose a risk to the world's emergence from the Covid-19 pandemic.

Hmmmmmm writes: China is developing a powerful nuclear reactor for its moon and Mars missions, according to researchers involved in the project. The reactor can generate one megawatt of electric power, 100 times more powerful than a similar device Nasa plans to put on the surface of the moon by 2030. The project was launched with funding from the central government in 2019. Although technical details and the launch date were not revealed, the engineering design of a prototype machine was completed recently and some critical components have been built, two scientists who took part in the project confirmed to the South China Morning Post this week.

To China, this is an ambitious project with unprecedented challenges. The only publicly known nuclear device it has sent into space is a tiny radioactive battery on Yutu 2, the first rover to land on the far side of the moon in 2019. That device could only generate a few watts of heat to help the rover during long lunar nights. Chemical fuel and solar panels will no longer be enough to meet the demands of human space exploration, which is expected to expand significantly with human settlements on the moon or Mars on the agenda, according to the Chinese researchers. "Nuclear power is the most hopeful solution. Other nations have launched some ambitious plans. China cannot afford the cost of losing this race," said one researcher with the Chinese Academy of Sciences who asked not to be named as they were not authorised to speak to the media.

Germany is set to decide on tougher Covid-19 restrictions and could even opt for a full lockdown amid record daily infections and mounting pressure on hospitals. From a report: Olaf Scholz, Germany's chancellor-designate, said Wednesday that the Covid situation was serious and that the country would massively push its vaccination campaign, noting that "vaccination is the way out of this pandemic." Scholz said Germany "should make vaccination compulsory for certain groups," without stating which groups, while new Finance Minister Christian Lindner stated that Germans should avoid all unnecessary contact this winter "to preserve all of our health in this pandemic."

That Scholz chose to address the Covid crisis as he and his new government colleagues announced a draft coalition deal on Wednesday shows where the officials' immediate priorities lie. The country's outgoing health minister, Jens Spahn, issued a dire warning to Germans this week, saying that by the end of winter "pretty much everyone in Germany will be vaccinated, recovered or dead." Outgoing Chancellor Angela Merkel has called on the heads of Germany's 16 federal states (which have largely been free to determine their own Covid measures) to decide upon stricter rules by Wednesday. On Tuesday, Spahn reiterated that request, adding that more public spaces should be restricted to the vaccinated, the recently recovered, or those that have had a negative test -- otherwise known as the "3G rule." From Wednesday, 3G rules apply to any Germans going into the workplace or accessing public transport.

President Joe Biden will require essential, nonresident travelers crossing U.S. land borders, such as truck drivers, government and emergency response officials, to be fully vaccinated beginning on Jan. 22, the administration planned to announce Tuesday. The Associated Press reports: A senior administration official said the requirement, which the White House previewed in October, brings the rules for essential travelers in line with those that took effect earlier this month for leisure travelers, when the U.S. reopened its borders to fully vaccinated individuals. Essential travelers entering by ferry will also be required to be fully vaccinated by the same date, the official said. The rules pertain to non-U.S. nationals. American citizens and permanent residents may still enter the U.S. regardless of their vaccination status, but face additional testing hurdles because officials believe they more easily contract and spread COVID-19 and in order to encourage them to get a shot. [...] About 47 million adults in the U.S. remain unvaccinated, according to figures from the Centers for Disease Control and Prevention.

If all goes as planned, a SpaceX Falcon 9 rocket carrying the Double Asteroid Redirection Test (DART) will launch early Wednesday morning "to test whether slamming a spacecraft into an asteroid can nudge it into a different trajectory," reports The New York Times. "Results from the test, if successful, will come in handy if NASA and other space agencies ever need to deflect an asteroid to save Earth and avert a catastrophic impact." From the report: The DART spacecraft is scheduled to lift off atop a SpaceX Falcon 9 rocket on Wednesday at 1:20 a.m. Eastern time (or 10:20 p.m. local time) from the Vandenberg Space Force Base in California. NASA plans to host a livestream of the launch on its YouTube channel starting at 12:30 a.m. on Wednesday. If bad weather around the Vandenberg launch site prompts a delay, the next opportunity for liftoff would be about 24 hours later.

After launching to space, the spacecraft will make nearly one full orbit around the sun before it crosses paths with Dimorphos, a football-field-size asteroid that closely orbits a bigger asteroid, called Didymos, every 11 hours and 55 minutes. Astronomers call those two asteroids a binary system, where one is a mini-moon to the other. Together, the two asteroids make one full orbit around the sun every two years. Dimorphos poses no threat to Earth, and the mission is essentially target practice. DART's impact will happen in late September or early October next year, when the binary asteroids are at their closest point to Earth, roughly 6.8 million miles away.

Four hours before impact, the DART spacecraft, formally called a kinetic impactor, will autonomously steer itself straight toward Dimorphos for a head-on collision at 15,000 miles per hour. An onboard camera will capture and send back photos to Earth in real time until 20 seconds before impact. A tiny satellite from the Italian Space Agency, deployed 10 days before the impact, will come as close as 34 miles from the asteroid to snap images every six seconds in the moments before and after DART's impact.

California is in the process of approving new guidelines for math education in public schools that "pushes Algebra 1 back to 9th grade, de-emphasizes calculus, and applies social justice principles to math lessons," writes Joe Hong via the San Francisco Standard. The new approach would have been approved earlier this month but has been delayed due to the attention and controversy it has received. Here's an excerpt from the report: When Rebecca Pariso agreed to join a team of educators tasked in late 2019 with California's new mathematics framework, she said she expected some controversy. But she didn't expect her work would be in the national spotlight. [...] Every eight years (PDF), a group of educators comes together to update the state's math curriculum framework. This particular update has attracted extra attention, and controversy, because of perceived changes it makes to how "gifted" students progress -- and because it pushes Algebra 1 back to 9th grade, de-emphasizes calculus, and applies social justice principles to math lessons. San Francisco pioneered key aspects of the new approach, opting in 2014 to delay algebra instruction until 9th grade and to push advanced mathematics courses until at least after 10th grade as a means of promoting equity.

San Francisco Unified School District touted the effort as a success, asserting that algebra failure rates fell and the number of students taking advanced math rose as a result of the change. The California Department of Education cited those results in drafting the statewide framework. But critics have accused the district of using cherry-picked and misleading assertions to bolster the case for the changes. The intent of the state mathematics framework, its designers say, is to maintain rigor while also helping remedy California's achievement gaps for Black, Latino and low-income students, which remain some of the largest in the nation. At the heart of the wrangling lies a broad agreement about at least one thing: The way California public schools teach math isn't working. On national standardized tests, California ranks in the bottom quartile among all states and U.S. territories for 8th grade math scores.

Yet for all the sound and fury, the proposed framework, about 800-pages long, is little more than a set of suggestions. Its designers are revising it now and will subject it to 60 more days of public review. Once it's approved in July, districts may adopt as much or as little of the framework as they choose -- and can disregard it completely without any penalty. "It's not mandated that you use the framework," said framework team member Dianne Wilson, a program specialist at Elk Grove Unified. "There's a concern that it will be implemented unequally."

Not a single scientist has applied to a UK government visa scheme for Nobel prize laureates and other award winners since its launch six months ago, New Scientist reported Tuesday. From a report: The scheme has come under criticism from scientists and has been described as "a joke." In May, the government launched a fast-track visa route for award-winners in the fields of science, engineering, the humanities and medicine who want to work in the UK. This prestigious prize route makes it easier for some academics to apply for a Global Talent visa -- it requires only one application, with no need to meet conditions such as a grant from the UK Research and Innovation funding body or a job offer at a UK organisation.

The number of prizes that qualify academics for this route currently stands at over 70, and includes the Turing Award, the L'Oreal-UNESCO for Women in Science International Awards, and various gongs awarded by professional or membership bodies both in the UK and elsewhere. "Winners of these awards have reached the pinnacle of their career and they have so much to offer the UK," said home secretary Priti Patel when the prestigious prize scheme launched in May. "This is exactly what our new point-based immigration system was designed for -- attracting the best and brightest based on the skills and talent they have, not where they've come from." But a freedom of information request by New Scientist has revealed that in the six months since the scheme was launched, no one working in science, engineering, the humanities or medicine has actually applied for a visa through this route.

A short update on the projected launch date of the $10 billion James Webb Space Telescope came out of NASA on Monday, and it wasn't exactly a heart-warming missive. From a report: The large, space-based telescope's "no earlier than" launch date will slip from December 18 to at least December 22 after an "incident" occurred during processing operations at the launch site in Kourou, French Guiana. That is where the telescope will launch on an Ariane 5 rocket provided by the European Space Agency. "Technicians were preparing to attach Webb to the launch vehicle adapter, which is used to integrate the observatory with the upper stage of the Ariane 5 rocket," NASA said in a blog post. "A sudden, unplanned release of a clamp band -- which secures Webb to the launch vehicle adapter -- caused a vibration throughout the observatory."

Hmmmmmm shares a report from SciTechDaily: Investigators from Brigham and Women's Hospital and MIT used the power of nanotechnology to discover a new way that cancer can disarm its would-be cellular attackers by extending out nanoscale tentacles that can reach into an immune cell and pull out its powerpack. Slurping out the immune cell's mitochondria powers up the cancer cell and depletes the immune cell. The new findings, published in Nature Nanotechnology, could lead to new targets for developing the next generation of immunotherapy against cancer.

To investigate how cancer cells and immune cells interact at the nanoscale level, [corresponding author Shiladitya Sengupta, PhD, and co-director of the Brigham's Center for Engineered Therapeutics] and colleagues set up experiments in which they co-cultured breast cancer cells and immune cells, such as T cells. Using field-emission scanning electron microscopy, they caught a glimpse of something unusual: Cancer cells and immune cells appeared to be physically connected by tiny tendrils, with widths mostly in the 100-1000 nanometer range. (For comparison, a human hair is approximately 80,000 to 100,000 nanometers). In some cases, the nanotubes came together to form thicker tubes. The team then stained mitochondria -- which provide energy for cells -- from the T cells with a fluorescent dye and watched as bright green mitochondria were pulled out of the immune cells, through the nanotubes, and into the cancer cells.

"By carefully preserving the cell culture condition and observing intracellular structures, we saw these delicate nanotubes and they were stealing the immune cells' energy source," said co-corresponding author Hae Lin Jang, PhD, a principal investigator in the Center for Engineered Therapeutics. "It was very exciting because this kind of behavior had never been observed before in cancer cells. This was a tough project as the nanotubes are fragile and we had to handle the cells very gently to not break them." The researchers then looked to see what would happen if they prevented the cancer cells from hijacking mitochondria. When they injected an inhibitor of nanotube formation into mouse models used for studying lung cancer and breast cancer, they saw a significant reduction in tumor growth.

IEEE Spectrum reports on the progress being made to develop a "smart artificial pancreas" that senses blood glucose and administers insulin accordingly. An anonymous reader shares an excerpt from the report: The artificial pancreas is finally at hand. This is a machine that senses any change in blood glucose and directs a pump to administer either more or less insulin, a task that may be compared to the way a thermostat coupled to an HVAC system controls the temperature of a house. All commercial artificial pancreas systems are still "hybrid," meaning that users are required to estimate the carbohydrates in a meal they're about to consume and thus assist the system with glucose control. Nevertheless, the artificial pancreas is a triumph of biotechnology.

It is a triumph of hope, as well. We well remember a morning in late December of 2005, when experts in diabetes technology and bioengineering gathered in the Lister Hill Auditorium at the National Institutes of Health in Bethesda, Md. By that point, existing technology enabled people with diabetes to track their blood glucose levels and use those readings to estimate the amount of insulin they needed. The problem was how to remove human intervention from the equation. A distinguished scientist took the podium and explained that biology's glucose-regulation mechanism was far too complex to be artificially replicated. [Boris Kovatchev, a scientist at the University of Virginia, director of the UVA Center for Diabetes Technology, and a principal investigator of the JDRF Artificial Pancreas Project] and his colleagues disagreed, and after 14 years of work they were able to prove the scientist wrong.

It was yet another confirmation of Arthur Clarke's First Law: "When a distinguished but elderly scientist states that something is possible, he is almost certainly right. When he states that something is impossible, he is very probably wrong." [...] Progress toward better automatic control will be gradual; we anticipate a smooth transition from hybrid to full autonomy, when the patient never intervenes. Work is underway on using faster-acting insulins that are now in clinical trials. Perhaps one day it will make sense to implant the artificial pancreas within the abdominal cavity, where the insulin can be fed directly into the bloodstream, for still faster action. What comes next? Well, what else seems impossible today?

A rare manuscript by theoretical physicist Albert Einstein goes under the hammer in Paris on Tuesday, with auctioneers aiming for a stratospheric price tag. Phys.Org reports: The manuscript, containing preparatory work for Einstein's key achievement the theory of relativity, is estimated at between two and three million euros (2.3-3.4 million), according to Christie's which is hosting the sale on behalf of the Aguttes auction house. "This is without a doubt the most valuable Einstein manuscript ever to come to auction," Christie's said in a statement.

The 54-page document was handwritten in 1913 and 1914 in Zurich, Switzerland, by Einstein and his colleague and confidant, Swiss engineer Michele Besso. Christie's said it was thanks to Besso that the manuscript was preserved for posterity. This was "almost like a miracle" since the German-born genius himself would have been unlikely to hold on to what he considered to be a simple working document, Christie's said. Today, the paper offers "a fascinating plunge into the the mind of the 20th century's greatest scientist," it said.

Zebra stripes are unique to each individual zebra, reports LiveScience, in an article shared by long-time Slashdot reader fahrbot-bot. And even if you look at the three different zebra species, their skin is always the same color: black (according to Tim Caro, a behavioral and evolutionary ecologist and conservation biologist at the University of California, Davis).

But this still doesn't answer the question of whether their fur is black with white stripes or white with black stripes. For that, we have to look to the zebra's melanocytes, or the cells that produce pigment for their fur. Although zebras have black skin, different developmental processes determine their fur color, just like a light-skinned person can have dark hair, Caro said. In fact, zebras actually have more light-colored hair than dark — their bellies are usually light — so it may seem that zebras are white with black stripes.

But that's not the case. Here's why: Every piece of hair — both light and dark — grows from a follicle filled with melanocyte cells, according to a 2005 review in the Journal of Investigative Dermatology. These cells produce a pigment that determines the color of hair and skin. This pigment is known as melanin; a lot of melanin leads to darker colors, like dark brown or black, while less melanin leads to lighter colors, such as hazel or blond, Live Science previously reported. Zebras' black fur is chock-full of melanin, but melanin is absent from white fur, in essence, because the follicles that make up the stripes of white hair have "turned off" melanocytes, meaning they don't churn out pigment.

The production of melanin from melanocytes is "prevented during the development of a white hair, but not of a black hair," Caro told Live Science in an email. In other words, for zebras, the animals' default state is to produce black hair, making them black with white stripes, according to Brittanica.... This unique pattern may keep away biting flies, according to research by Caro and his colleagues. In a study published in 2020 in the journal Proceedings of the Royal Society B, they found that African horseflies landed less frequently on horses wearing striped or checked rugs than they did on horses wearing solid-colored rugs. These biting flies can carry diseases that are fatal to zebras.

National Geographic reports: About a million years ago, an asteroid smacked into the normally tranquil surface of Mars. The impact released a fountain of debris, and some of the rocky fragments pierced the sky, escaping the planet's gravity to journey through the dark. Some of the rocks eventually found their way to Earth and survived the plunge through our planet's atmosphere to thud into the surface-including a hefty 15-pound shard that crashed into Morocco in 2011.... Determining what part of Mars these meteorites came from is a critical part of piecing together the planet's history — but it's proven to be a major scientific challenge.

Now, with the assistance of a crater-counting machine learning program, a team of researchers studying the depleted shergottites may have finally cracked the case: They concluded that these geologic projectiles came from a single crater atop Tharsis, the largest volcanic feature in the solar system. This ancient volcanic behemoth on Mars is adorned with thousands of individual volcanoes and extends three times the area of the continental United States. It was built over billions of years by countless magma injections and lava flows. It is so heavy that, as it formed, it effectively tipped the planet over by 20 degrees. If these meteorites do come from Tharsis, as the analysis published in Nature Communications suggests, then scientists have their hands on meteorites that can help identify the infernal forces that fueled the construction of this world-tipping edifice. "This could really change the game about how we understand Mars," says Luke Daly, a meteorite expert at the University of Glasgow who was not involved with the study.
Debris from meteor impacts tend to also form smaller craters — so the scientists trained their machine learning tools to scan orbital images of Mars to find appropriately-sized crazers (less than two thirds of a mile long). "It quickly found about 90 million, says Kosta Servis, a data scientist at Curtin University and co-author of the study..."

But after sifting through the data, "the team identified 19 large craters in volcanic regions on Mars that were surrounded by multiple secondary craters — a sign that these planetary scars could be as young as the 1.1-million-year-old crater they sought..." Out of those 19 craters, just two were excavated from youthful volcanic deposits by an impact event 1.1 million years ago: crater 09-00015 and Tooting crater. The latter (named after a district in London) looks to have been formed by a powerful oblique impact — the kind of collision that would propel a lot of Martian meteorites into space..."

Buoyed by their discovery, Lagain's team is hoping to identify the source craters of other Martian meteorites — including some of the very oldest, which could reveal more about Mars's waterlogged past.... Machine learning "is a really inventive way of trying to tackle this problem," says Lauren Jozwiak, a planetary volcanologist at Johns Hopkins University Applied Physics Laboratory not involved with the study. "Boy, I hope this method works," she says, because if it does, "it would be really cool to take this and apply it to other planets."

CNN reports on researcher Michael Worobey, "who specializes in tracing the genetic evolution of viruses," who has now found "considerable evidence that the virus arose in an animal, and did not start circulating until the end of 2019." One case especially stood out — that of a 41-year-old accountant who allegedly got sick on December 8, 2019 and who had no connection to the market. The case has been cited as evidence the pandemic must not have started at the market.

Worobey found records that showed the man didn't become ill with Covid-19 until later in December and that his December 8 problem was related to his teeth.

"This is corroborated by hospital records and a scientific paper that reports his COVID-19 onset date as 16 December and date of hospitalization as 22 December," Worobey wrote in a commentary in the journal Science. That would make a seafood vendor who worked at the market and who got sick December 11, 2019, the earliest documented case, Worobey said.

Other research helped Worobey come up with a map of the earliest cases that clusters them all around the market. "That so many of the more than 100 COVID-19 cases from December with no identified epidemiologic link to Huanan Market nonetheless lived in its direct vicinity is notable and provides compelling evidence that community transmission started at the market," he wrote. "It tells us that there's a big red flashing arrow pointing at Huanan Market as the most likely place that the pandemic started," Worobey told CNN. "The virus didn't come from some other part of Wuhan and then get to Huanan market. The evidence speaks really quite strongly to the virus starting at the market and then leaking into the neighborhoods around the market...."

The journal Science subjected Worobey's research to outside scrutiny before publishing it.
Interestingly, Science also published a letter in May in which Worobey had joined 17 other scientists to urge the investigation of both the "natural origin" and "lab leak" theories. But now while he still believes the Chinese government should've investigated the lab leak theory, "holy smokes — is there a lot of evidence against it, and in favor of natural origin," Worobey tells CNN. And he's now telling the Los Angeles Times that his new research "takes the lab-leak idea almost completely off the table.... So many of the early cases were tied to this one Home Depot-sized building in a city of 11 million people, when there are thousands of other places where it would be more likely for early cases to be linked to if the virus had not started there."

Or, as he explained his research to the Washington Post, "It becomes almost impossible to explain that pattern if that epidemic didn't start there."

A virologist at Texas A&M University who was one of the coronavirus experts giving SARS-CoV-2 its name called Worobey's research "detailed and compelling," while a virologist at Tulane University also tells the Post the new research "shows beyond a shadow of a doubt that in fact the Huanan market was the epicenter of the outbreak."

"An Australian company is part of an international effort to recycle dangerous space junk into rocket fuel — in space," reports the Guardian.

Slashdot reader votsalo shared their report (which also looks at some of the other companies working on the problem of space debris). South Australian company Neumann Space has developed an "in-space electric propulsion system" that can be used in low Earth orbit to extend the missions of spacecraft, move satellites, or de-orbit them. Now Neumann is working on a plan with three other companies to turn space junk into fuel for that propulsion system... Another U.S. company, Cislunar, is developing a space foundry to melt debris into metal rods. And Neumann Space's propulsion system can use those metal rods as fuel — their system ionises the metal which then creates thrust to move objects around orbit.

Chief executive officer Herve Astier said when Neumann was approached to be part of a supply chain to melt metal in space, he thought it was a futuristic plan, and would not be "as easy as it looks".

"But they got a grant from NASA so we built a prototype and it works," he said...

Astier says it is still futuristic, but now he can see that it's possible. "A lot of people are putting money into debris. Often it's to take it down into the atmosphere and burn it up. But if it's there and you can capture it and reuse it, it makes sense from a business perspective, because you're not shipping it up there," he said.

"It's like developing a gas station in space."

"Although Oumuamua probably isn't some probe looking for humpbacked whales," writes Slashdot reader alaskana98, "it does continue to deliver plenty of intrigue — and controversy — for those astronomy buffs out there.

"In the latest move in the war on who gets to define what exactly OuMuaMua is, Harvard astrophysicists Amir Siraj and Avi Loeb have countered the prevailing hypothesis that it is a frozen chunk of nitrogen with their own — that it is simply not possible."

LiveScience reports: According to Siraj and his co-author, Harvard astrophysicist Avi Loeb, Jackson and Desch's conclusion that 'Oumuamua is a nitrogen iceberg is flawed because there isn't enough nitrogen in the universe to make an object like 'Oumuamua, which is somewhere between 1,300 and 2,600 feet (400 and 800 meters) long and between 115 and 548 feet (35 and 167 m) wide.

Pure nitrogen is rare, Siraj said, and has been found only on Pluto, where it makes up about 0.5% of the total mass. Even if all of the nitrogen ice in the universe was scraped off every Pluto-like planet that's predicted to exist, there still wouldn't be enough nitrogen to make 'Oumuamua.

An anonymous reader quotes a report from Phys.org: NASA and the nation's top federal nuclear research lab on Friday put out a request for proposals for a fission surface power system. NASA is collaborating with the U.S. Department of Energy's Idaho National Laboratory to establish a sun-independent power source for missions to the moon by the end of the decade. If successful in supporting a sustained human presence on the moon, the next objective would be Mars. NASA says fission surface power could provide sustained, abundant power no matter the environmental conditions on the moon or Mars. The reactor would be built on Earth and then sent to the moon.

Submitted plans for the fission surface power system should include a uranium-fueled reactor core, a system to convert the nuclear power into usable energy, a thermal management system to keep the reactor cool, and a distribution system providing no less than 40 kilowatts of continuous electric power for 10 years in the lunar environment. Some other requirements include that it be capable of turning itself off and on without human help, that it be able to operate from the deck of a lunar lander, and that it can be removed from the lander and run on a mobile system and be transported to a different lunar site for operation. Additionally, when launched from Earth to the moon, it should fit inside a 12-foot (4-meter) diameter cylinder that's 18 feet (6 meters) long. It should not weigh more than 13,200 pounds (6,000 kilograms). The proposal requests are for an initial system design and must be submitted by Feb. 19.

Satellite trackers have been working overtime to figure out just how much dangerous debris Russia created when it destroyed one of its own satellites early Monday -- and the picture they've painted looks bleak. Multiple visual simulations of Russia's anti-satellite, or ASAT, test show a widespread cloud of debris that will likely menace other objects in orbit for years. The Verge reports: It's going to take weeks or even months to fully understand just how bad the situation is, but early visualizations of the ASAT test created by satellite trackers show an extensive trail of space debris left in the wake of the breakup. The fragments appear like a dotted snake in orbit, stretching out and moving in roughly the same direction that Kosmos 1408 used to move around Earth. And there's one thing the visualizers agree on: this snake of debris isn't going anywhere anytime soon. "There will be some potential collision risk to most satellites in [low Earth orbit] from the fragmentation of Cosmos 1408 over the next few years to decades," LeoLabs, a private space tracking company in the US, wrote in a blog post.

Two visualizations created by the European Union's Space Surveillance and Tracking (SST) network and space software company AGI reveal what likely happened in the first moment of impact when Russia's missile intercepted Kosmos 1408. They both show how the debris cloud grew instantly and spread throughout space. AGI's simulation also shows just how close the cloud comes to intersecting with the International Space Station, validating NASA's concerns and the agency's decision to have the astronauts shelter in place.

Another visualization created by Hugh Lewis, a professor of engineering at the University of Southampton specializing in space debris, shows just how widely the debris from Kosmos 1408 has spread out in space. Lewis explains that when Russia's missile hit the satellite, each of the fragments that were created got a little kick, sending them to higher and lower altitudes. Each piece is moving at a different speed depending on the height of its orbit. Lewis says that the cloud will continue to morph over time. The debris fragments in the lower orbits will fall to Earth and out of orbit more quickly, while the ones in higher orbits will stay in space much longer.

NASA has now released the most detailed footage yet of Ingenuity in flight. Gizmodo reports: The two videos were taken during the rotorcraft's 13th flight, which took place on September 4. The 16-second flight saw Ingenuity travel nearly 700 feet horizontally, at an altitude of 26 feet. The Perseverance rover recorded the rotorcraft's maneuvers using its two-camera Mastcam-Z, from a distance of about 1,000 feet away.

"The value of Mastcam-Z really shines through with these video clips," Justin Maki, deputy principal investigator for the Mastcam-Z instrument at NASA's Jet Propulsion Laboratory in Southern California, said in a NASA press release. "Even at 300 meters [984 feet] away, we get a magnificent closeup of takeoff and landing through Mastcam-Z's âright eye.' And while the helicopter is little more than a speck in the wide view taken through the 'left eye,' it gives viewers a good feel for the size of the environment that Ingenuity is exploring."

Recently, the scientists at NASA had to program Ingenuity to move a little faster, to compensate for the thinner atmosphere on Mars as the planet's seasons change. The helicopter's navigation system is automated and uses artificial intelligence to constantly measure and correct for environmental variables like wind speed and the level of the ground below it. "It's awesome to actually get to see this [automatic correction] occur," said Havard Grip, Ingenuity's chief pilot, in the same release. "It reinforces the accuracy of our modeling and our understanding of how to best operate Ingenuity."

An anonymous reader quotes a report from the Guardian: [R]esearchers have created a hi-tech option for canines left home alone: a ball that allows them to call their owners on the old dog and bone. The device -- nicknamed the DogPhone -- is a soft ball that, when moved, sends a signal to a laptop that launches a video call, and the sound of a ringing telephone. The owner can choose whether to take the call, and when to hang up, while they can also place a call to their pet -- although the dog has to move the ball to pick up.

The research, which is published in the Proceedings of the Association for Computing Machinery on Computer-Human interaction and is being presented at the 2021 ACM Interactive Surfaces and Spaces Conference in Lodz, Poland, reveals how [Dr Ilyena Hirskyj-Douglas, of the University of Glasgow, and first author of the research] and researchers from Aalto University in Finland settled on a soft ball to create the device. The DogPhone underwent a number of iterations to ensure it had the right level of sensitivity towards movement -- these were tested over 16 days by Hirskyj-Douglas and her nine-year-old black labrador, Zack.

A diary detailing the calls between owner and pet suggests the latter did not always seem to know what he was doing -- despite having been shown five times how the system worked. "Dog rang me but was not interested in our call instead was checking for things in his bed," Hirskyj-Douglas noted during the testing of one iteration. Another entry reveals the potential pitfalls of the DogPhone. "Dog walking around wagging and then laying down. I was in a meeting so had to hang up quickly," one record reveals. The team say that many of the calls made by Zack -- who was left alone for about eight hours during testing days -- appear to have been accidents although they caution that may simply be the human perspective. "For example, when the dog triggered the system with their butt, this could have been deliberate and the dog's unique way of triggering an interaction," they write.

UPDATE: While one group of physicians has complained that the FDA is slow-walking the release of vaccine-approval documents, Snopes.com points out you can also see this story from a different perspective: A scheduling dispute related to a Freedom of Information Act (FOIA) request for more than than 329,000 pages of COVID-19 vaccine data led to misleading social media posts in November 2021. The U.S. Food and Drug Administration (FDA) proposed a schedule to process and release 500 pages every month, arguing that this is the standard rate to process FOIA requests as "reviewing and redacting records for exempt information is a time-consuming process." The FDA would start releasing this data immediately, but the full set of pages would not be processed until 2076. The FDA argued that the amount of time required to fulfill this request is due to the broad FOIA request that involves hundreds of thousands of pages.
Snopes emphasizes that the FDA "did not request a delay in the release of its COVID-19 data until 2076," and notes they were responding to a request for the 329,000 pages in just 108 days with a very small number of qualified respondents. "Courts do not waiver from the standard 500 page per month processing rate even when a FOIA request would take years to process..." [reads the FDA's response]. "FDA has invited Plaintiff to narrow its request by specifying records it no longer wants FDA to process and release, and Plaintiff has declined to do so. If Plaintiff decides to request fewer records, then FDA will be able to complete its processing at an earlier date."
Snopes adds that the scheduling issue will be settled by a U.S. district judge next month.

Slashdot reader schwit1 had shared this report from Substack, written by Aaron Siri. He is the Managing Partner of Siri & Glimstad, a law firm representing the plaintiffs in the case. From the report: The FDA has asked (PDF) a federal judge to make the public wait until the year 2076 to disclose all of the data and information it relied upon to license Pfizer's COVID-19 vaccine. That is not a typo. It wants 55 years to produce this information to the public. As explained in a prior article, the FDA repeatedly promised "full transparency" with regard to Covid-19 vaccines, including reaffirming "the FDA's commitment to transparency" when licensing Pfizer's COVID-19 vaccine.

With that promise in mind, in August and immediately following approval of the vaccine, more than 30 academics, professors, and scientists from this country's most prestigious universities requested the data and information submitted to the FDA by Pfizer to license its COVID-19 vaccine. The FDA's response? It produced nothing. So, in September, my firm filed a lawsuit against the FDA on behalf of this group to demand this information. To date, almost three months after it licensed Pfizer's vaccine, the FDA still has not released a single page. Not one. Instead, two days ago, the FDA asked a federal judge to give it until 2076 to fully produce this information. The FDA asked the judge to let it produce the 329,000+ pages of documents Pfizer provided to the FDA to license its vaccine at the rate of 500 pages per month, which means its production would not be completed earlier than 2076. Further reading: FDA Wants 55 Years To Process FOIA Request Over Vaccine Data (Paywalled Reuters story)

An anonymous reader quotes a report from CNBC: The CDC's independent panel of vaccine scientists unanimously endorsed Pfizer and Moderna's boosters for all adults, one of the final regulatory steps before the U.S. can officially start distributing the doses. The Advisory Committee on Immunization Practices voted to recommend the shots. The Food and Drug Administration authorized both company's vaccine boosters for everyone 18 and over earlier on Friday, and CDC Director Rochelle Walensky is expected to clear the doses soon after. The panel's recommendation would open up eligibility to everyone 18 and over in the U.S., but the group more strongly endorsed shots for older Americans by saying everyone 50 and over should get a booster. It previously said people over 65 and some other high-risk people should get a third shot. Once Walensky signs off, tens of millions of Americans who've received their two initial shots at least six months ago will be eligible to get a third shot as soon as early as this weekend. "Pfizer said its booster dose was 95% effective at preventing symptomatic infection in people who had no evidence of prior infection in a clinical trial of 10,000 participants 16 years and older," notes CNBC. "Moderna didn't submit its efficacy data for its booster, telling the panel it was still gathering the data."

Abstract of a paper published on Nature: The use of psychedelic substances at sub-sensorium 'microdoses,' has gained popular academic interest for reported positive effects on wellness and cognition. The present study describes microdosing practices, motivations and mental health among a sample of self-selected microdosers (n = 4050) and non-microdosers (n = 4653) via a mobile application. Psilocybin was the most commonly used microdose substances in our sample (85%) and we identified diverse microdose practices with regard to dosage, frequency, and the practice of stacking which involves combining psilocybin with non-psychedelic substances such as Lion's Mane mushrooms, chocolate, and niacin. Microdosers were generally similar to non-microdosing controls with regard to demographics, but were more likely to report a history of mental health concerns. Among individuals reporting mental health concerns, microdosers exhibited lower levels of depression, anxiety, and stress across gender. Health and wellness-related motives were the most prominent motives across microdosers in general, and were more prominent among females and among individuals who reported mental health concerns. Our results indicate health and wellness motives and perceived mental health benefits among microdosers, and highlight the need for further research into the mental health consequences of microdosing including studies with rigorous longitudinal designs.

Apple co-founder Steve Wozniak's startup Privateer aims to help humanity get the goods on space junk before it's too late. Space.com reports: The Hawaii-based company, whose existence Wozniak and co-founder Alex Fielding announced in September, wants to characterize the ever-expanding space debris population like never before. Privateer will do this by incorporating a variety of data, including crowdsourced information and observations made by its own sizable satellite fleet. "I think we're looking at several hundred satellites," Privateer Chief Scientific Adviser Moriba Jah told Space.com. "We won't launch all several hundred at once; we'll just slowly build it up."

Orbital debris is already tracked by a number of organizations, including the U.S. military and private companies such as LeoLabs. Privateer wants to contribute to these efforts and help ramp them up, eventually creating the "Google Maps of space," as Fielding told TechCrunch last month. To make this happen, Privateer, which is still in "stealth mode" at the moment, plans to build and analyze a huge debris dataset that incorporates information from a variety of sources. "We want to basically be a company that's focused on decision intelligence by aggregating massive quantities of disparate and heterogeneous information, because there's something to be gained in the numbers," said Jah, a space debris expert who's also an associate professor of aerospace engineering and engineering mechanics at the University of Texas at Austin.

Privateer will purchase some of this information, crowdsource some of it and gather still more using its own satellites, Jah said. The first of those satellites is on track to launch this coming February, he added. This information will lead to much more than a census of space junk, if all goes according to plan. The company intends also to characterize debris objects, nailing down their size, shape and spin rate, among other features. "The catalogs of objects out there all treat things like they're spheres," Jah said. "We're going to take it beyond the sphere, to what the thing more realistically looks like and is." Such information will allow satellite operators and others in the space community to better gauge the threat posed by debris objects and improve their predictions about how long pieces of junk will stay aloft, he added. Privateer will make some of its analyses and data freely available for the public good and sell others to customers.

Tesseractic shares a report from New Scientist, written by Chen Ly: A satellite has been successfully powered by iodine for the first time. Iodine performed better than the traditional propellant of choice, xenon -- highlighting iodine's potential utility for future space missions. Currently, xenon is the main propellant used in electric propulsion systems, but the chemical is rare and expensive to produce. As a gas, xenon must also be stored at very high pressures, which requires specialized equipment. Iodine has a similar atomic mass to xenon but is more abundant and much cheaper. It can also be stored as an unpressurised solid, meaning it has the potential to simplify satellite designs.

Dmytro Rafalskyi at ThrustMe, a space technology company based in France, and his colleagues have developed an electric propulsion system that uses iodine. The propulsion system first heats up a solid block of iodine, turning it into a gas. The gas is bombarded with high-speed electrons, which turns it into a plasma of iodine ions and free electrons. Negatively charged hardware then accelerates the positively charged iodine ions from the plasma towards the system's exhaust and propels the spacecraft forwards. [...] The group found that the iodine system slightly outperformed xenon systems, with a higher overall energy efficiency, which showcases the viability of iodine as a propellant. "There are some difficulties with iodine that need to be addressed says Rafalskyi," the report adds. "For example, iodine reacts with most metals, so the team had to use ceramics and polymers to protect parts of the propulsion system. In addition, solid iodine takes about 10 minutes to turn into a plasma, which may not provide a propellant quickly enough for emergency maneuvers to avoid an in-orbit collisions."

The research has been published in the journal Nature.

An anonymous reader quotes a report from CNBC: Elon Musk on Wednesday said SpaceX is "hoping" to launch the first orbital flight test of its mammoth Starship rocket in January, a schedule that depends on testing and regulatory approval. "We'll do a bunch of tests in December and hopefully launch in January," Musk said, speaking at a meeting of the National Academies of Sciences, Engineering, and Medicine Space Studies Board.

The company's next major step in developing Starship is launching to orbit. First, the company needs a launch license from the Federal Aviation Administration for the mission, with the regulator expecting to complete a key environmental assessment by the end of this year. Musk noted that he wasn't sure if Starship would successfully reach orbit on the first try, but emphasized that he is "confident" that the rocket will get to space in 2022. "We intend to have a high flight rate next year," Musk said.

SpaceX aims to launch as many as a dozen Starship test flights next year, he said, to complete the "test flight program" and move to launching "real payloads in 2023." He stressed that creating a mass production line for Starship is crucial to the program's long-term goals, noting that the current "biggest constraint" on rocket manufacturing is how fast the company can build the Raptor engines needed for Starship. "I think, in order for life to become multiplanetary, we'll need maybe 1,000 ships or something like that," Musk said. "The overarching goal of SpaceX has been to advance space technology such that humanity can become a multi-planet species and, ultimately, a spacefaring civilization." SpaceX received a $2.9 billion contract from NASA to develop Starship for delivering astronauts to the moon's surface, but Musk said the company is "not assuming any international collaboration" or external funding for the rocket program. "[Starship] is at least 90% internally funded thus far," Musk said.

According to Amazon and Blue Origin founder Jeff Bezos, future generations "will visit Earth the way you visit Yellowstone National Park." Gizmodo reports: The remarks came last week at an event held at the National Cathedral in Washington, DC, with NASA Administrator Bill Nelson and others talking about space policy. Bezos sat down for a one-on-one chat with Adi Ignatius, the editor-in-chief of the Harvard Business Review. He brought up themes we've heard before, including his vision that all polluting industries will exist in space one day and that we'll all live on space colonies that could, in his estimation, support 1 trillion people. But he expanded on his vision in greater detail about what, exactly, will happen to the planet we'll all leave behind for Blue Origin-branded space colonies.

"This is the most precious planet in the world and we have to preserve it and conserve it and make sure that our children and their children and so on have this beauty in their lives," Bezos said. "We need to conserve what we have, restore what we've lost," he said. "This planet is so small, if we want to keep growing as a civilization, using energy as a civilization, most of that needs to be done off-planet. ... This place is special. You can't ruin it." To do that will require us all to live in space colonies. That would leave Earth to eventually be, in Bezos' vision, a place for future folks to visit but not live. "They may visit Earth the way you visit Yellowstone National Park," Bezos said. Ignatius asked a follow-up about who gets to live on Earth in this vision, which Bezos did not answer. "It's extremely telling that Bezos' vision for the future of Earth is Yellowstone National Park," comments Gizmodo's Brian Kahn, a former park ranger. "Bezos' big idea of turning Earth into Yellowstone elides the fact that humans are as much a part of this planet as they were part of Yellowstone before Americans showed up. He's pitching a very Western solution to the very Western problem of climate change and environmental degradation, problems that Bezos' very own businesses have played a major role in while enriching him to the point where he now has a huge sway on humanity's next step."

"NASA is not properly estimating costs for the Artemis program and could spend $93 billion between fiscal years 2021 and 2025," writes Slashdot reader schwit1. "NASA recently extended its target date for sending astronauts back to the moon to 2025 at the earliest." But, according to a new report (PDF) from NASA's Office of the Inspector General, it could be several years after 2024. The Verge reports: The recent prediction comes from NASA's Office of the Inspector General, which does periodic audits of the space agency's various programs. In its latest report, the OIG took a comprehensive look at NASA's Artemis program, the agency's ambitious initiative to send people back to the Moon, as well as land the first woman and the first person of color on the lunar surface. [...] NASA's Artemis program relies on a suite of complicated vehicles all working together to get astronauts safely to the Moon, including a massive new rocket called the Space Launch System, or SLS, that will send people to deep space inside a new crew capsule called Orion. Meanwhile, SpaceX is developing its next-generation spacecraft, called Starship, to carry people to and from the lunar surface for NASA -- part of a $2.9 billion contract awarded to the company in April.

However, Starship is still in very early stages of development and has yet to launch to orbit. SLS and Orion also have not flown on their first flight together. The OIG report, released Monday, highlights these issues and reveals just how much work is left to be done on Artemis, making a 2024 landing date unrealistic. "Given the time needed to develop and fully test the HLS and new spacesuits, we project NASA will exceed its current timetable for landing humans on the Moon in late 2024 by several years," the report states. [...] Rival space company Blue Origin had also hoped to receive a contract from NASA to develop a lunar lander, but when the space agency gave the award to SpaceX, the company sued in federal court. The lawsuit prevented NASA and SpaceX from working together on the lander until the litigation was resolved.

The OIG report notes that the lawsuit did have an impact on the overall schedule, but the office also argues that the development schedule for SpaceX's Starship is overly optimistic. SpaceX CEO Elon Musk continues to make bold predictions for Starship's first major test launch, claiming multiple times it'd be ready to fly to orbit for the first time this year. However, the OIG report estimates the first orbital flight test of Starship will occur sometime in the second quarter of 2022. The document does argue that SpaceX may be able to shave off some time due to its speedy testing pace compared with earlier NASA spaceflight programs. But there is still quite a lot of work to be done after Starship's orbital flight test. [...] The OIG report predicts that the debut of NASA's SLS rocket and Orion combo will also be delayed.

An anonymous reader quotes a report from The Verge: The Food and Drug Administration authorized a virtual reality system as a prescription treatment for chronic back pain, the agency announced today. The therapy, called EaseVRx, joins the short list of digital therapeutics cleared by the agency over the past few years. EaseVRx includes a VR headset and a device that amplifies the sound of the user's breath to assist in breathing exercises. It uses principles from cognitive behavior therapy, which aims to help people recognize and understand various thought patterns and emotions. The program addresses pain through relaxation, distraction, and improved awareness of internal signals, the FDA said in its statement.

The FDA authorized EaseVRx based on data from an eight-week study in 179 people with low back pain that had lasted six months or longer. Half used the EaseVRx program and half participated in another, two-dimensional virtual reality program that did not use cognitive behavioral therapy methods. Around two-thirds of participants using EaseVRx said they had more than 30 percent reduction in pain, while only 41 percent of the control group had a similar reduction. The reduced pain lasted for up to three months after the study for people in the EaseVRx group but not for the control group. The VR system could be an alternative option to opioid medications for back pain, Christopher Loftus, acting director of the Office of Neurological and Physical Medicine Devices at the FDA, said in a statement. [...] EaseVRx was developed by the company AppliedVR, which is also testing its platform as a treatment for fibromyalgia pain, burn pains, or pain during childbirth. The clearance for EaseVRx comes around a month after the FDA approved a VR treatment for children with the visual disorder amblyopia, or lazy eye.

A new space mission to hunt for potentially habitable planets around Earth's closest neighbouring star system is under way. From a report: In a project with echoes of the 2009 film Avatar, an international collaboration of scientists in Australia and the US will search in the Alpha Centauri star system for earth-like planets that could sustain life. Alpha Centauri -- Earth's closest neighbouring star system -- consists of two sun-like stars, known as Alpha Centauri A and B, and a more distant red dwarf star. The Toliman mission, named after the ancient Arabic-derived name for the star system, will search for potential planets orbiting Alpha Centauri A and B.

The Toliman telescope, which is under construction, is set to be launched into low-earth orbit in 2023. It seeks to discover new planets in the "Goldilocks orbit" -- at the right distance, so the planet is neither too hot nor too cold to sustain life. Project leader Prof Peter Tuthill, of the University of Sydney, said: "If we're looking for life as we know it, usually the gold standard is a planet where liquid water could be present at the surface of the planet â" so it's not like a frozen snowball, and it doesn't boil all the water up into the atmosphere." "We know that life has evolved at least once, around a sun-like star on an earth-like planet," Tuthill said. "We try to look for other examples that are as close to that configuration as possible."

It's one of the most intriguing questions about the Solar System from the last five years: Is there a large planet, lurking out in the cold dark reaches, on an orbit so wide it could take 20,000 years to complete? The answer has proven elusive, but a new study reveals what could be traces of the mysterious hypothetical object's existence. From a report: Astronomer Michael Rowan-Robinson of Imperial College London in the UK conducted an analysis of data collected by the Infrared Astronomical Satellite (IRAS) in 1983, and found a trio of point sources that just might be Planet Nine. This, Rowan-Robinson concludes in his preprint paper, is actually fairly unlikely to be a real detection, but the possibility does mean that it could be used to model where the planet might be now in order to conduct a more targeted search, in the quest to confirm or rule out its existence. "Given the poor quality of the IRAS detections, at the very limit of the survey, and in a very difficult part of the sky for far infrared detections, the probability of the candidate being real is not overwhelming," he wrote.

"However, given the great interest of the Planet 9 hypothesis, it would be worthwhile to check whether an object with the proposed parameters and in the region of sky proposed, is inconsistent with the planetary ephemerides." Speculation about the existence of a hidden planet in the outer reaches of the Solar System has swirled for decades, but it reached a new pitch in 2016 with the publication of a paper proposing new evidence. Astronomers Mike Brown and Konstantin Batygin of Caltech found that small objects in the outer Solar System's Kuiper Belt were orbiting oddly, as though pushed into a pattern under the gravitational influence of something large.

But finding the dratted thing is a lot more complicated than it might sound. If it is out there, it could be five to 10 times the mass of Earth, orbiting at a distance somewhere between 400 and 800 astronomical units (an astronomical unit is the average distance between Earth and the Sun; Pluto, for context, is around 40 astronomical units from the Sun). This object is very far away, and quite small and cold and probably not reflecting much sunlight at all; and, moreover, we don't know exactly where in the very large sky it is. So the jury is out on whether it is real or not, and the topic is one of pretty intense and interesting debate. IRAS operated for 10 months from January 1983, taking a far-infrared survey of 96 percent of the sky. In this wavelength, small, cool objects like Planet Nine might be detectable, so Rowan-Robinson decided to re-analyze the data using parameters consistent with Planet Nine.

An anonymous reader quotes a report from Ars Technica: The seven astronauts and cosmonauts onboard the International Space Station sheltered inside their respective spacecraft, a Crew Dragon and Soyuz, on Monday morning as the orbiting laboratory passed through an unexpected debris field. This was not a pre-planned collision avoidance maneuver in low Earth orbit, in which the station would use onboard propulsion to move away. Rather, the situation required the astronauts to quickly take shelter. Had there been a collision during the conjunction, the two spacecraft would have been able to detach from the space station and make an emergency return to Earth. Ultimately that was not necessary, and the astronauts reemerged into the space station later Monday. However, as the crew on board the station prepared for their sleep schedule, Mission Control in Houston asked them to keep as many of the hatches onboard the space station closed for the time being, in case of an unexpected collision during subsequent orbits.

It appears likely that the debris field that had alarmed flight controllers on Monday was caused by an anti-satellite test performed by Russia's military early on Monday. [...] It appears that Russia launched a surface-to-space Nudol missile on Monday, between 02:00 and 05:00 UTC, from the Plesetsk Cosmodrome in the northern part of the country. The missile then struck an older satellite, Cosmos 1408. Launched in 1982, the satellite had been slowly losing altitude and was a little more than 450 km above the Earth. This is a large satellite, with a mass of about 2,000 kg. As of Monday afternoon, US Space Command said it was already tracking more than 1,000 pieces of new debris. Although the satellite's altitude is higher than the International Space Station, which is about 400 km above the surface, a kinetic impact would spread a large cloud of debris. Satellite expert Jonathan McDowell believes the Cosmos 1408 satellite is the likely candidate for the space station's ongoing debris event.

During a daily briefing today, US State Department Spokesman Ned Price said the test had created more than 1,500 pieces of trackable debris and hundreds of thousands of pieces of un-trackable debris. "The Russian Federation recklessly conducted a destructive satellite test of a direct-ascent anti-satellite missile against one of its own satellites," Price said. "This test will significantly increase the risk to astronauts and cosmonauts on the International Space Station as well as to other human spaceflight activities. Russia's dangerous and irresponsible behavior jeopardizes the long-term sustainability of outer space."

Heavy rain and flooding in Aswan, Egypt, have driven drifts of scorpions to seek shelter in people's homes. From a report: Three people died and more than 400 were hospitalised across the governorate to receive anti-venom treatment after being stung by the panicking arachnids, according to state-run media. However, acting Health Minister Khalid Abdel-Ghafar said in a statement that no deaths were reported from the stings. The Ministry of Health has reassured the public that it holds a large enough stock of anti-venom, noting that 3,350 doses were available in Aswan. The downpours and subsequent floods have also forced local authorities to suspend schools on Sunday, Governor Ashraf Attia said.