Micro- and nanoplastic particles "infiltrate all systems of the body, including the brain," notes the University of Rhode Island, "where they can accumulate and trigger Alzheimer's-like conditions, according to a new study by researchers in the University of Rhode Island College of Pharmacy."

ScienceDaily shares the announcement: After a previous study that showed how microplastics can infiltrate all systems of the body — including the blood-brain barrier, which protects the brain from harmful substances as small as viruses and bacteria — University of Rhode Island pharmacy assistant professor Jaime Ross expanded the study to determine the brain health impacts of the plastic toxins. Her findings indicate that the accumulation of micro- and nanoplastics in the brain can lead to cognitive decline and even Alzheimer's disease, especially in those who carry genetic risk factors.

Ross' latest study, published recently in the journal Environmental Research Communications, examined mice that had been genetically modified to include the naturally occurring gene APOE4, a strong indicator of Alzheimer's risk making people 3.5 times more likely to develop the disease than those who carry the APOE3 variant of the gene that is passed from parents to offspring... Ross and her team exposed two groups of mice — one with the APOE4 variant and one with APOE3 — to micro- and nanoplastics in their drinking water over a period of three weeks. The tiny particles from polystyrene — among the most abundant plastics in the world, found in Styrofoam take-out containers, plastic cups and more — infiltrated the mice' organs, including the brain, as expected...

Ross' team then ran the mice through a series of tests to examine their cognitive ability, beginning with an open-field test, in which researchers put a mouse in a chamber and allow it to explore at will for 90 minutes. Ordinarily, a mouse will hug the walls, naturally attempting to hide from potential predators. However, after microplastic exposure, the APOE4 mice — especially the male mice — tended to wander more in the middle of the chamber and spend time in open space, leaving themselves vulnerable to predators...

The results are concerning enough to warrant further study into the cognitive decline caused by exposure to micro- and nanoplastics, which are among the most prominent environmental toxins to which people are routinely exposed... Ross is continuing to expand her research into the topic and encourages others to do so, in the hope of leading to better regulation of the toxins.

alternative_right shares a report from Phys.org: Scientists from Taiwan have developed a new material that can stretch up to 4,600% of its original length before breaking. Even if it does break, gently pressing the pieces together at room temperature allows it to heal, fully restoring its shape and stretchability within 10 minutes.

The sticky and stretchy polyurethane (PU) organogels were designed by combining covalently linked cellulose nanocrystals (CNCs) and modified mechanically interlocked molecules (MIMs) that act as artificial molecular muscles. The muscles make the gel sensitive to external forces such as stretching or heat, where its color changes from orange to blue based on whether the material is at rest or stimulated. Thanks to these unique properties, the gels hold great promise for next-generation technologies -- from flexible electronic skins and soft robots to anti-counterfeiting solutions. The findings have been published in the journal Advanced Functional Materials.

A new Stanford-led study finds that switching permanently to standard time could prevent 300,000 strokes and reduce obesity in 2.6 million Americans by better aligning circadian rhythms with natural light. Researchers argue that the twice-yearly clock changes are the worst option for public health, while permanent daylight saving time would offer two-thirds of the benefits. From a report: "We found that staying in standard time or staying in daylight saving time is definitely better than switching twice a year," senior researcher Jamie Zeitzer said in a news release. He's a professor of psychiatry and behavioral sciences at Stanford University in California. For the study, researchers estimated how different national time policies might affect American's circadian rhythms -- the body's innate clock that regulates many physiological processes. The human circadian cycle isn't exactly 24 hours, researchers noted. It's about 12 minutes longer for most people, and it can be changed based on a person's exposure to light.

"When you get light in the morning, it speeds up the circadian cycle. When you get light in the evening, it slows things down," Zeitzer said. "You generally need more morning light and less evening light to keep well synchronized to a 24-hour day." An out-of-sync circadian cycle has been linked with many different poor health outcomes, researchers said. "The more light exposure you get at the wrong times, the weaker the circadian clock," Zeitzer said. "All of these things that are downstream -- for example, your immune system, your energy -- don't match up quite as well." Most people would experience the least circadian burden under permanent standard time, which prioritizes morning light, researchers found.

The research team then linked its analysis of circadian rhythms to county-level data from the U.S. Centers for Disease Control and Prevention (CDC) to see how each time policy might affect people's health. Their models showed that permanent standard time would reduce obesity nationwide by 0.78% and stroke by 0.09%. Those seemingly small percentage changes, when played out across the national population, would mean 2.6 million fewer people with obesity and 300,000 fewer cases of stroke. Permanent daylight savings time would result in a 0.51% drop in obesity -- around 1.7 million people -- and a 0.04% reduction in strokes, or 220,000 cases. Either move would help American health. "You have people who are passionate on both sides of this, and they have very different arguments," Zeitzer said. The findings have been published in the Proceedings of the National Academy of Sciences.

"Phys.org is reporting on a study published in Nature Physics involving ICN2 at the UAB campus, Xi'an Jiaotong University (Xi'an) and Stony Brook University (New York), showing for the first time that ordinary ice is a flexoelectric material -- meaning it can generate electricity when subjected to mechanical deformation," writes longtime Slashdot reader fahrbot-bot. From the report: "We discovered that ice generates electric charge in response to mechanical stress at all temperatures. In addition, we identified a thin 'ferroelectric' layer at the surface at temperatures below -113C (160K)," explains Dr. Xin Wen, a member of the ICN2 Oxide Nanophysics Group and one of the study's lead researchers. "This means that the ice surface can develop a natural electric polarization, which can be reversed when an external electric field is applied -- similar to how the poles of a magnet can be flipped. The surface ferroelectricity is a cool discovery in its own right, as it means that ice may have not just one way to generate electricity, but two: ferroelectricity at very low temperatures, and flexoelectricity at higher temperatures all the way to 0 C." This property places ice on a par with electroceramic materials such as titanium dioxide, which are currently used in advanced technologies like sensors and capacitors.

An anonymous reader quotes a report from Ars Technica: As Jonathan Roll neared completion of a master's degree in science and technology policy at Arizona State University three years ago, he did some research into recent developments by China's ascendant space program. He came away impressed by the country's growing ambitions. Now a full-time research analyst at the university, Roll was recently asked to take a deeper dive into Chinese space plans. "I thought I had a pretty good read on this when I was finishing grad school," Roll told Ars. "That almost everything needed to be updated, or had changed three years later, was pretty scary. On all these fronts, they've made pretty significant progress. They are taking all of the cues from our Western system about what's really galvanized innovation, and they are off to the races with it."

Roll is the co-author of a new report, titled "Redshift," on the acceleration of China's commercial and civil space activities and the threat these pose to similar efforts in the United States. Published on Tuesday, the report was sponsored by the US-based Commercial Space Federation, which advocates for the country's commercial space industry. It is a sobering read and comes as China not only projects to land humans on the lunar surface before the US can return, but also is advancing across several spaceflight fronts to challenge America. "The trend line is unmistakable," the report states. "China is not only racing to catch up -- it is setting pace, deregulating, and, at times, redefining what leadership looks like on and above Earth. This new space race will not be won with a single breakthrough or headline achievement, but with sustained commitment, clear-eyed vigilance, and a willingness to adapt over decades." "The key takeaway here is that there is an acceleration," said Dave Cavossa, president of the Commercial Spaceflight Federation. "The United States is still ahead today in a lot of areas in space. But the Chinese are advancing very quickly and poised to overtake us in the next five to 10 years if we don't do something."

"There's other things along the lines of budget battles," Cavossa said. "We don't want to see the US government scaling back its reliance on commercial satellite communications. We don't want to see them scaling back commercial remote sensing data buys, which is what they've been doing, or at least threatening to do. We want to make sure that there's a seamless transition from the ISS to commercial LEO destinations, and then a transition away from old programs of record to commercial transportation alternatives. That's what the US government can do and Congress can do here in the next couple of years to make sure that we stay ahead."

"Engineers from Ohio State University are developing a new way to power rocket engines," reports Gizmodo, "using liquid uranium for a faster, more efficient form of nuclear propulsion that could deliver round trips to Mars within a single year..." Nuclear propulsion uses a nuclear reactor to heat a liquid propellant to extremely high temperatures, turning it into a gas that's expelled through a nozzle and used to generate thrust. The newly developed engine concept, called the centrifugal nuclear thermal rocket (CNTR), uses liquid uranium to heat rocket propellant directly. In doing so, the engine promises more efficiency than traditional chemical rockets, as well as other nuclear propulsion engines, according to new research published in Acta Astronautica...

Traditional chemical engines produce about 450 seconds of thrust from a given amount of propellant, a measure known as specific impulse. Nuclear propulsion engines can reach around 900 seconds, with the CNTR possibly pushing that number even higher. "You could have a safe one-way trip to Mars in six months, for example, as opposed to doing the same mission in a year," Spencer Christian, a PhD student at Ohio State and leader of CNTR's prototype construction, said in a statement.

CNTR promises faster routes, but it could also use different types of propellant, like ammonia, methane, hydrazine, or propane, that can be found in asteroids or other objects in space.
"Some potential hurdles include ensuring that the methods used for startup, operation and shutdown avoid instabilities," according to the researchers' announcement, as well as "envisioning ways to minimize the loss of uranium fuel and accommodate potential engine failures."

But "This team's CNTR concept is expected to reach design readiness within the next five years..."

The oldest person living in Japan is 114 years old, reports the BBC. But "The number of people in Japan aged 100 or older has risen to a record high of nearly 100,000, its government has announced." Setting a new record for the 55th year in a row, the number of centenarians in Japan was 99,763 as of September, the health ministry said on Friday. Of that total, women accounted for an overwhelming 88%... Health minister Takamaro Fukoka congratulated the 87,784 female and 11,979 male centenarians on their longevity and expressed his "gratitude for their many years of contributions to the development of society"....

The higher life expectancy is mainly attributed to fewer deaths from heart disease and common forms of cancer, in particular breast and prostate cancer. Japan has low rates of obesity, a major contributing factor to both diseases, thanks to diets low in red meat and high in fish and vegetables. The obesity rate is particularly low for women, which could go some way to explaining why Japanese women have a much higher life expectancy than their male counterparts... But it's not just diet. Japanese people tend to stay active into later life, walking and using public transport more than elderly people in the US and Europe...

However, several studies have cast doubt on the validity of global centenarian numbers, suggesting data errors, unreliable public records and missing birth certificates may account for elevated figures. A government audit of family registries in Japan in 2010 uncovered more than 230,000 people listed as being aged 100 or older who were unaccounted for, some having in fact died decades previously. The miscounting was attributed to patchy record-keeping and suspicions that some families may have tried to hide the deaths of elderly relatives in order to claim their pensions.

Many coral reefs "have now turned ghostly white," reports CBS News — and "a major culprit is climate change."

SFGate adds that more than 50% of the world's coral reefs have been lost, mostly over the past 10 years, according to coral reef scientist Rebecca Albright at the California Academy of Sciences. "If changes aren't made soon, 90% to 99% of the coral reefs that are remaining could be deteriorated by 2050, Albright said..."

But CBS News notes that Albright's lab is the first in America to successfully spawn coral to regenerate the reefs: The lab is mastering the art and science of creating baby corals, and the scientists have brought their expertise into the wild. The location: the second-largest reef in the world, known as the Mesoamerican Reef, stretching some 700 miles along the coasts of Mexico, Belize, Guatemala, and Honduras... Armed with test tubes, the scientists quickly dove into the water and collected the tiny packets of gametes. Back on land, the eggs were fertilized, incubated, and then brought back into the wild. "Then we planted over 3,000 baby corals back to the reef," explained Albright. The baby corals are now two months old. The Roatan staff will dive in a few months to see how many survived.
Scientists are worried because bleaching events "are becoming more common," notes SFGate, "happening more frequently and affecting more parts of the world... The most current event was confirmed on April 15, 2024, and is still ongoing, impacting approximately 84% of the world's coral reefs as of August 31.

"It has been documented in at least 83 countries and territories."

One of the worlds in the TRAPPIST-1 system, a mere 40 light-years away, just might be clad in a life-supporting atmosphere," reports ScienceAlert.

"In exciting new JWST observations, the Earth-sized exoplanet TRAPPIST-1e shows hints of a gaseous envelope similar to our own, one that could facilitate liquid water on the surface." Although the detection is ambiguous and needs extensive follow-up to find out what the deal is, it's the closest astronomers have come yet in their quest to find a second Earth... [T]he first step is finding exoplanets that are the right distance from their host star, occupying a zone where water neither freezes under extreme cold nor evaporates under extreme heat. Announced in 2016, the discovery of the TRAPPIST-1 system was immediately exciting for this reason. The red dwarf star hosts seven exoplanets that have a rocky composition (as opposed to gas or ice giants), several of which are bang in the star's habitable, liquid water zone...

Red dwarf stars are also much more active than Sun-like stars, rampant with flare activity that, scientists have speculated, may have stripped any planetary atmospheres in the vicinity. Closer inspections of TRAPPIST-1d, one of the other worlds in the star's habitable zone, have turned up no trace of an atmosphere. But TRAPPIST-1e is a little more comfortably located, at a slightly greater distance from the star... [T]he spectrum is consistent with an atmosphere rich in molecular nitrogen, with trace amounts of carbon dioxide and methane.

This is pretty tantalizing. Earth's atmosphere is roughly 78 percent molecular nitrogen. If the results can be validated, TRAPPIST-1e might just be the most Earth-like exoplanet discovered to date. That is not a small if, though. Luckily, more JWST observations are in the pipeline, and the researchers should be able to validate or rule out an atmosphere very soon.
After analyzing four transits of TRAPPIST-1e across TRAPPIST-1, "We are seeing two possible explanations," says astrophysicist Ryan MacDonald of the University of St Andrews in the UK. "The most exciting possibility is that TRAPPIST-1e could have a so-called secondary atmosphere containing heavy gases like nitrogen. "But our initial observations cannot yet rule out a bare rock with no atmosphere..."

Astrophysicist Ana Glidden of MIT led the second team interpreting the results, and says "We are really still in the early stages of learning what kind of amazing science we can do with Webb. It's incredible to measure the details of starlight around Earth-sized planets 40 light-years away and learn what it might be like there, if life could be possible there."

"We're in a new age of exploration that's very exciting to be a part of."

After its six-year journey to Saturn's moon Titan, Dragonfly's rotorcraft lander "will fly like a large drone," explains its web page, spending three years sampling multiple landing sites to characterize Titan's habitability and look for "precursors of the origin of life." "However, the project has undergone multiple replans impacting cost and schedule, resulting in a life-cycle cost increase of nearly $1 billion and over 2 years of delays," according to an announcement from NASA's Inspector General.

From the Inspector General's report: The cost increase and schedule delay were largely the result of NASA directing [Johns Hopkins University] Applied Physics Laboratory to conduct four replans between June 2019 and July 2023 early in Dragonfly's development. Justifications for these replans included the COVID-19 pandemic, supply chain issues, changes to accommodate a heavy-lift launch vehicle, projected funding challenges, and inflation."
But its higher-than-expected life-cycle cost over $3 billion "will continue to absorb an increasing proportion of the Planetary Science Division's total budget," meaning Dragonfly's increased cost (and "additional budget constraints") have "contributed to a gap of at least 12 years in New Frontiers [planetary science] mission launches, and will jeopardize future priorities outlined in the National Academies of Sciences, Engineering, and Medicine's (National Academies) decadal surveys."

Yet a NASA press release notes the mission "has cleared several key design, development and testing milestones and remains on track toward launch in July 2028." Its software-defined radio has been completed, and the part of the spectrometer which analyzes Titan's chemical components for "potentially biologically relevant" compounds (as well as structural and thermal testing of the lander's insulation).

"The mission is scheduled to launch in July 2028 on a SpaceX Falcon Heavy launch vehicle from NASA's Kennedy Space Center in Florida."

Thanks to long-time Slashdot reader schwit1 for spotting this news on the space/science blog "Behind the Black".

Finland's second-largest university has announced new research suggesting that heart attacks could be an infectious disease.

[T]he research found that, in coronary artery disease, atherosclerotic plaques containing cholesterol may harbor a gelatinous, asymptomatic biofilm formed by bacteria over years or even decades. Dormant bacteria within the biofilm remain shielded from both the patient's immune system and antibiotics because they cannot penetrate the biofilm matrix.

A viral infection or another external trigger may activate the biofilm, leading to the proliferation of bacteria and an inflammatory response. The inflammation can cause a rupture in the fibrous cap of the plaque, resulting in thrombus [blood clot] formation and ultimately myocardial infarction... "Bacterial involvement in coronary artery disease has long been suspected, but direct and convincing evidence has been lacking," explains professor Pekka Karhunen [who led the study with researchers from the UK and Finland]. "Our study demonstrated the presence of genetic material — DNA — from several oral bacteria inside atherosclerotic plaques." The findings were validated by developing an antibody targeted at the discovered bacteria, which unexpectedly revealed biofilm structures in arterial tissue. Bacteria released from the biofilm were observed in cases of myocardial infarction. The body's immune system had responded to these bacteria, triggering inflammation which ruptured the cholesterol-laden plaque.

The observations pave the way for the development of novel diagnostic and therapeutic strategies for myocardial infarction. Furthermore, they advance the possibility of preventing coronary artery disease and myocardial infarction by vaccination.
"The research is part of an extensive EU-funded cardiovascular research project involving 11 countries..."

The Washington Post notes that past research "indicates that exercise helps some cancer survivors avoid recurrence of their disease."

But a new study "offers an explanation of how, showing that exercise changes the inner workings of our muscles and cells, although more study is still needed..." The study, published last month, involved 32 women who'd survived breast cancer. After a single session of interval training or weightlifting, their blood contained higher levels of certain molecules, and those factors helped put the brakes on laboratory-grown breast cancer cells. "Our work shows that exercise can directly influence cancer biology, suppressing tumor growth through powerful molecular signals," said Robert Newton, the deputy director of the Exercise Medicine Research Institute at Edith Cowan University in Perth, Australia, and senior author of the new study. His group's experiment adds to mounting evidence that exercise upends the risks of not only developing but also surviving cancer...

Scientists know contracting muscles release a slew of hormones and biochemicals, known as myokines, into our bloodstreams and have long suspected these myokines fight cancer. In some past studies with mice and healthy people, blood drawn after exercise and added to live cancer cells killed or suppressed the cancer's growth... [The new study tested cancer cells in high-tech petri dishes with blood drawn from cancer survivors.] Drenched in plasma from either the interval trainers or the lifters, many cancer cells quit growing. Quite a few died. (The blood drawn before exercise had no effects.) The cancer-fighting impacts were greatest with the blood drawn after interval training. Why? Additional testing showed this blood contained the highest concentrations of certain, beneficial myokines, especially IL-6, a protein that affects immune responses and inflammation...

What these results mean, Newton said, is that "exercise doesn't just improve fitness and well-being" in people who've had cancer. "It also orchestrates a complex biological response that includes direct anticancer signals from muscles..." Questions remain, of course. Can any type of exercise fight cancer? Newton and other researchers have doubts. The exercise in this study was strenuous, by design. "Earlier studies suggested that the stronger the exercise stimulus, the greater the release of anticancer myokines," Newton said... Even the weight training in this study was less potent than the intense intervals. But Newton believes weight training remains key to cancer fighting. "People with cancer who increase their muscle mass through resistance training also experience greater rises in circulating myokines," he said. More muscle means more myokines.

Surgeons in London report a surge in severe e-bike-related injuries, putting major strain on NHS trauma units. The BBC mentions a couple e-bike accidents overheard at the Royal London Hospital in Whitechapel. "A 32-year-old, fit and well student... a couple of days ago he fell off an e-bike sustaining a closed left tibial plateau fracture." Another case involved a little girl named Frida: "Six-year-old girl, she was hit by an electric bike, she has a closed tib/fib fracture." From the report: Surgeon Jaison Patel is seeing more and more cases like this. "It's a massive burden on our department and I'm sure it's the same across the whole of London," he tells us. "If we can reduce the number of patients coming in with these sorts of injuries it would be great for the patients obviously, but also takes massive pressure off us in the NHS."

Jaison deals with lower limb injuries. Just along the corridor his colleague Nick Aresti does the upper limbs. Nick explains that he is a cyclist himself, and it's something he encourages people to do for the benefit of their health. But, he has real concerns about e-bikes, and says: "What we've noticed with e-bikes is that the speed in which people are coming off is much higher and as a result, the injuries are much worse." He shows us X-rays of someone who has broken their collarbone. He explains that with e-bikes, the injuries they're seeing are much more severe, and as such, people are "struggling to get back to normality."

Nick and Jaison both agree it's something they're seeing increasingly more of as time goes by, and they think the industry needs better regulation. "We should do something about it, I don't think we can let this carry on," Jaison says. Over recent days of course, thousands of Londoners have taken to e-bikes to help beat the strikes. For many it has been an essential way to get about. Currently, anyone aged 14 or over can legally ride an e-bike. The power output of an e-bike's motor should be capped at 250 watts, and the motor should not be capable of propelling the bike any faster than 15.5mph (25kph), according to government rules.

London's Walking and Cycling Commissioner Will Norman says the rules need changing and says better regulation of the rentable electric bikes could be on the way. "We need to ensure that the vehicles are safe, that there's parking, they're not scattered all over the place, and that the batteries are safe," he says. "I'm really delighted that the government has now indicated in its English Devolution Bill that London and other cities across the UK will be getting more powers so again we can start regulating that, to ensure that they're safe for people to use and operate while they get around". The bill is currently going through parliament, and as yet there is no date for when it will be passed. Duncan Dollimore, head of campaigns at Cycling UK, who are members of the Electric Bike Alliance, argues against the regulation of e-bike usage. "The cost of inactivity-related health issues to the NHS each year is 7.4 billion pounds, and people cycling saves them 1 billion pounds. We have seen a slight rise in the number of incidents involving hired e-bikes in London, but the health benefits of people cycling outweigh the risks by around 20 to one."

Researchers in China have created synthetic magnetic fields within silicon photonic crystals, allowing them to steer and control light on a chip with unprecedented precision. "Beyond immediate applications, the work opens new avenues for studying quantum-inspired phenomena with light," reports Phys.org. "The ability to impose artificial gauge fields in photonic systems could enable devices for optical computing, quantum information, and advanced communication technologies." Slashdot reader alternative_right shares an excerpt from the report: The team achieved this by systematically altering the symmetry of tiny repeating units in silicon photonic crystals. Adjusting the degree of local asymmetry at each point allowed them to 'design' pseudomagnetic fields with tailored spatial patterns, without breaking fundamental time-reversal symmetry. Both theoretical analysis and experiments confirmed that these engineered fields can guide and manipulate light in versatile ways. To demonstrate practical applications, the researchers built two devices commonly used in integrated optics. One was a compact S-shaped waveguide bend that transmitted light with less than 1.83 decibels of signal loss. The other was a power splitter that divided light into two equal paths with low excess loss and minimal imbalance. In a final test, the devices successfully transmitted a high-speed data stream at 140 gigabits per second using a standard telecommunications modulation format, showing that the technique is compatible with existing optical communication systems. The research has been published in Advanced Photonics.

Physicists have confirmed Stephen Hawking's 1971 black hole area theorem with near-absolute certainty, thanks to gravitational waves from an exceptionally loud black hole collision detected by upgraded LIGO instruments. New Scientist reports: Hawking proposed his black hole area theorem in 1971, which states that when two black holes merge, the resulting black hole's event horizon -- the boundary beyond which not even light can escape the clutches of a black hole -- cannot have an area smaller than the sum of the two original black holes. The theorem echoes the second law of thermodynamics, which states that the entropy, or disorder within an object, never decreases.

Black hole mergers warp the fabric of the universe, producing tiny fluctuations in space-time known as gravitational waves, which cross the universe at the speed of light. Five gravitational wave observatories on Earth hunt for waves 10,000 times smaller than the nucleus of an atom. They include the two US-based detectors of the Laser Interferometer Gravitational-Wave Observatory (LIGO) plus the Virgo detector in Italy, KAGRA in Japan and GEO600 in Germany, operated by an international collaboration known as LIGO-Virgo-KAGRA (LVK).

The recent collision, named GW250114, was almost identical to the one that created the first gravitational waves ever observed in 2015. Both involved black holes with masses between 30 and 40 times the mass of our sun and took place about 1.3 billion light years away. This time, the upgraded LIGO detectors had three times the sensitivity they had in 2015, so they were able to capture waves emanating from the collision in unprecedented detail. This allowed researchers to verify Hawking's theorem by calculating that the area of the event horizon was indeed larger after the merger. The findings have been published in the journal Physical Review Letters.