An anonymous reader quotes a report from Bloomberg: Unsealed emails reveal the role baby-powder maker Johnson & Johnson played in a report that an industry group submitted to U.S. regulators deciding whether to keep warnings off talc-based products linked to cancer. The emails -- unsealed in the state of Mississippi's lawsuit against J&J over its refusal to add a safety warning -- show J&J and its talc supplier chose the scientists hired by their trade association, the Personal Care Products Council, to write the 2009 report assessing talc-based powders' health risks. They also show the researchers changed the final version of their report at the companies' behest. The U.S. Food and Drug Administration said it relied in part on the report in its decision to forgo a warning for the product.

The emails among executives of J&J and Rio Tinto Minerals, its supplier at the time, provide a behind-the-scenes glimpse of dealings between companies and their industry group that successfully fended off a cancer warning on talc-based powders for nearly 40 years. Now, almost 39,000 users and their families are suing J&J, most claiming their ovarian cancers and those of loved ones were linked to asbestos, the potent carcinogen in the products pulled from U.S. and Canadian shelves in May 2020. Dependence on industry data creates a situation that's ripe for lobbyists to exert pressure on the FDA. The unsealed emails pull back the curtain on how such efforts get launched, who pays for them, and who has a hand in delivering the final product to regulators.

While the practice of companies having a say in industry group submissions to the FDA isn't new or illegal, the emails reveal just how involved J&J got in a report meant to assess product safety -- down to selecting individual scientists to produce it and having them write an executive summary. J&J denied any wrongdoing in its decision not to acknowledge its input to the report that the PCPC lobbying group sent to the FDA. [...] FDA officials acknowledged they weighed the PCPC's response to the citizens' petitions demanding a warning for talc-based powders before finding there was "inconclusive evidence" the mineral caused ovarian and other forms of cancer. "The FDA reviewed and considered all of the information submitted to us in the two petitions, the comments received in response to the petitions, and additional scientific information," said Tara Rabin, a spokeswoman.

Astronomers have detected a record number of gravitational waves, in a discovery they say will shed light on the evolution of the universe, and the life and death of stars. From a report: An international team of scientists have made 35 new observations of gravitational waves, which brings the total number of detections since 2015 to 90. Gravitational waves are ripples in the fabric of spacetime, created by massive cosmic events -- such as pairs of black holes smashing together -- up to billions of light years away. Waves from these cataclysmic collisions were detected by the Laser Interferometer Gravitational-Wave Observatory (Ligo) observatory in the US and the Virgo instrument in Italy between November 2019 and March 2020. The first detection of gravitational waves, announced in 2016, confirmed a prediction Albert Einstein made a century earlier based on his general theory of relativity. Monash University researcher Shanika Galaudage, a collaborator in the Australian branch of the project known as OzGrav, described gravitational waves as a game-changing "new window into the universe."

"Another space agency, about one-tenth the size of NASA, is thinking outside of the planet-sized box in its search for Martian life," reports CNET: With its Martian Moons Exploration mission (or MMX), the Japan Aerospace Exploration Agency, or JAXA, later this decade will touch down on a world no spacecraft has visited before: Phobos, one of Mars' mystifying moons. Scientists at JAXA, and other astronomers, hypothesize that on this curious moon they may find signs of ancient microbes that were catapulted off the surface of Mars and flung across the cosmos. The remains of these unwitting spacefaring organisms have been untouched for millions of years and, soon, could be plucked from Phobos' face and returned to Earth.

When an asteroid collides with a planet, the planet unleashes a mighty sneeze of dust and rock. The faster the asteroid smashes into the surface, the bigger the sneeze... [I]f the asteroid impact is powerful enough, the sneeze will fling dust and rock into space... Just like a human sneeze contains microbes, the material ejected by a planet may also contain microscopic life — or the remnants of it. If the asteroid death blast doesn't melt the rock and the microbes to mere atoms, there's a chance they can float into the cosmos... Mars is scarred by impacts from drifter asteroids that slammed into the surface over the planet's life. If these impacts were to hit in just the right spot, at just the right angle and just the right time, there's a chance the ejected material would make it to Phobos, Mars' curious, potato-shaped moon. Phobos has the closest orbit of any known moon to its parent body, circling the red planet at a distance of just 6,000 kilometers (3,700 miles), about the same as the distance between Tokyo and Honolulu....

Phobos is practically hugging Mars, and moves around the planet so quickly that if you were to observe it from the surface, you'd be able to see it rise and set twice every Martian day. Its proximity to the red planet has led JAXA scientists and engineers to speculate about the potential for finding the remnants of Martian microbes on the moon's surface. "If Martian life once existed and was widespread elsewhere on Mars, the chance that its dead remains exist also on Phobos is, in my opinion, relatively high," says Ryuki Hyodo, a planetary scientist at JAXA's Institute of Space and Astronautical Science... It's possible, JAXA believes, that Phobos could be a satellite cemetery, unwittingly holding molecular evidence of long-dead microorganisms....

With a planned sample return date of 2029, MMX would be the first time samples have been returned from the Martian sphere. While the space agency estimates just 0.1% of Phobos' soil likely originated on Mars, there's a chance MMX could bring back the first samples of the red planet to Earth.

Long-time Slashdot reader fahrbot-bot shared this report from the New York Times about a "particularly unusual" star about 150 light-years away that's orbited by three planets: What's unusual is the inclinations of the outer two planets, HD 3167 c and d. Whereas in our solar system all the planets orbit in the same flat plane around the sun, these two are in polar orbits. That is, they go above and below their star's poles, rather than around the equator as Earth and the other planets in our system do.

Now scientists have discovered the system is even weirder than they thought. Researchers measured the orbit of the innermost planet, HD 3167 b, for the first time — and it doesn't match the other two. It instead orbits in the star's flat plane, like planets in our solar system, and perpendicular to HD 3167 c and d. This star system is the first one known to act like this...

The unusual configuration of HD 3167 highlights just how weird and wonderful other stars and their planets can be. "It puts in perspective again what we think we know about the formation of planetary systems," said Vincent Bourrier from the University of Geneva in Switzerland, who led the discovery published last month in the journal Astronomy & Astrophysics.

"Planets can evolve in really, really different ways."

So how exactly did the universe come into existence? "A recent astronomical measurement recorded in a laboratory at the South Pole is causing scientists to revisit their theories..." writes Don Lincoln, a senior scientist at the Fermi National Accelerator Laboratory: In the intervening decades [since 1929], observations have only strengthened the case for the Big Bang theory, but they have also made it clear that the theory is incomplete. For instance, in its earliest incarnation, the Big Bang couldn't explain why the universe was so uniform. Astronomers in the Northern Hemisphere who looked deep into space see the same thing on average as ones that live in the Southern Hemisphere. Traditional Big Bang theory predicts that there should be small differences in temperature, clumpiness of large clusters of galaxies and other properties. But both sides look the same.

However, in 1980, physicist Alan Guth proposed an extension to the theory that could reconcile some of the inconsistencies between theory and observation, including the unexpected uniformity. His extension is called cosmic inflation theory and it claims that in the first moments of the birth of the universe it expanded faster than the speed of light.... However, if inflation is true, we should be able to prove it. Although the universe was once glowing hot, the expansion of the universe has cooled it off and that glow has morphed into microwaves that astronomers have been able to detect since 1964. This relic of the Big Bang is called the cosmic microwave background, or CMB. Inflation theory predicts that the microwaves of the CMB should be polarized...

The CMB can be polarized in two ways: B-modes, which are swirly patterns, and E-modes, which are more of a straight-line pattern. And, if inflation theory is correct, we'd expect to see some mix of B-modes and E-modes, while if it isn't correct — in other words, if the expansion of the universe did not happen as quickly as the theory suggests — researchers should only see E-modes... Astronomers used a telescope facility called BICEP-3 (short for Background Imaging of Cosmic Extragalactic Polarization) to study the CMB and its polarization. The telescope's South Pole location, with its altitude of nearly two miles above sea level and incredibly dry air, is an ideal place to conduct this kind of research. BICEP-3 scientists combined their data with measurements at other facilities and found no indication of B-modes originating from the CMB. If B-modes are present in the CMB, they are very small.

So, does that mean that the theory of inflation must be thrown out? No, although the data has disproved some of the simpler theories of inflation, it isn't sensitive enough to rule out the more complex versions. Still, the failure to observe CMB B-modes is unsettling, causing some scientists to go back to the drawing board.

An anonymous reader quotes a report from Green Market Report: Exclusively-natural psychedelic drug discovery company Filament Health Corp. received authorization from the FDA authorization to initiate the first clinical trial using naturally-sourced psychedelic substances. The news caused the stock to jump over 11% in early trading. The company said that this approval is the first for the direct administration of psilocin rather than its prodrug psilocybin and will administer Filament's three proprietary botanical drug candidates. The phase 1 trial is led by the Translational Psychedelic Research Program (TrPR) at the University of California San Francisco (UCSF).

The phase 1 trial has been designed to include 20 healthy subjects and will examine the effects of Filament's three proprietary botanical drug candidates: PEX010 (oral psilocybin), PEX020 (oral psilocin), and PEX030 (sublingual psilocin). As a result of the need for psilocybin to convert into psilocin before becoming active in the human body, the direct administration of psilocin may yield several therapeutic benefits such as faster onset time, greater consistency, increased bioavailability, and lessened side effects. These potential attributes are being studied in the authorized trial. In addition, psilocin is an ideal candidate for sublingual delivery because of the bypassing of the gut, where the conversion to psilocybin is thought to primarily occur. To date, synthetic manufacturers have been unable to produce a stable formulation of psilocin and enter it into a clinical trial. "We are excited to announce this milestone as validation of our ability to cultivate variable psychedelic biomass and transform it into pharmaceutical-grade drug candidates," said Chief Executive Officer, Benjamin Lightburn. "Our innovative technology has allowed us to create IP-protected botanical drug candidates of oral psilocin, sublingual psilocin, and oral psilocybin, and to enter them into an FDA-approved natural psychedelic clinical trial. Our candidates enjoy significant IP protection, unlike most other psychedelics currently under clinical investigation."

Amazon's Kuiper Systems asked U.S. regulators for permission to launch another 4,538 satellites that would bolster its constellation as it competes with Elon Musk's SpaceX for broadband-from-space customers. From a report: The additions would bring Kuiper's constellation to 7,774 satellites, the company said in a filing Thursday with the Federal Communications Commission. The companies are joining a rush to offer internet service from orbits near the Earth, spurred in a part by decreasing launch costs. Low orbits offer minimal lag time for data to bounce between a user on the ground and the spacecraft. Kuiper's request was among nine applications, submitted under an FCC deadline, that requested authorization for a total of more than 35,000 spacecraft. That's more than seven times the number aloft today. Those figures don't include nearly 30,000 additional satellites proposed by segment leader SpaceX, which already has launched more than 1,700 of its Starlink spacecraft.

Uneven vaccine coverage and a relaxation of preventive measures have brought Europe to a "critical point" in the pandemic, the World Health Organization has said, with cases again at near-record levels and 500,000 more deaths forecast by February. From a report: Hans Kluge, the WHO's Europe director, said all 53 countries in the region were facing "a real threat of Covid-19 resurgence or already fighting it" and urged governments to reimpose or continue with social and public health measures. "We are, once again, at the epicentre," he said. "With a widespread resurgence of the virus, I am asking every health authority to carefully reconsider easing or lifting measures at this moment." He said that even in countries with high vaccination rates, immunisation could only do so much.

"The message has always been: do it all," Kluge said. "Vaccines are doing what was promised: preventing severe forms of the disease and especially mortality ... But they are our most powerful asset only if used alongside public health and social measures." Catherine Smallwood, WHO Europe's senior emergency officer, said countries that had mostly lifted preventive measures had experienced a surge in infections.

About half of the world's fossil fuel assets will be worthless by 2036 under a net zero transition, according to research. From a report: Countries that are slow to decarbonise will suffer but early movers will profit; the study finds that renewables and freed-up investment will more than make up for the losses to the global economy. It highlights the risk of producing far more oil and gas than required for future demand, which is estimated to leave $11tn-$14tn in so-called stranded assets -- infrastructure, property and investments where the value has fallen so steeply they must be written off. The lead author, Jean-Francois Mercure of the University of Exeter, said the shift to clean energy would benefit the world economy overall, but it would need to be handled carefully to prevent regional pockets of misery and possible global instability. "In a worst-case scenario, people will keep investing in fossil fuels until suddenly the demand they expected does not materialise and they realise that what they own is worthless. Then we could see a financial crisis on the scale of 2008," he said, warning oil capitals such as Houston could suffer the same fate as Detroit after the decline of the US car industry unless the transition is carefully managed.

Pfizer's oral antiviral drug was found to reduce the risk of hospitalization or death from COVID-19 by 89%, according to interim results from a mid-to-late-stage study announced by the company on Friday. From a report: Antiviral drugs can be a key pandemic-fighting tool, as not everyone will get vaccinated against the virus and it may take years to fully inoculate people in certain countries -- particularly given current gaps in global vaccine supplies. Pfizer CEO Albert Bourla said in a statement that these findings from the phase 2/3 study marked "a real game-changer in the global efforts to halt the devastation of this pandemic." Pfizer's antiviral pill, PAXLOVID (PF-07321332), was developed specifically to treat COVID-19, by blocking activity of the main enzyme the virus needs to multiply. This was co-administered with a low dose of ritonavir, which is widely used in combination treatments for HIV infection.

An anonymous reader quotes a report from The Guardian: The virus that causes Covid-19 does not infect human brain cells, according to a study published in the journal Cell. The findings will raise hopes that the damage caused by Sars-CoV-2 might be more superficial and reversible than previously feared. The study contradicts earlier research that suggested the virus infects neurons in the membrane that lines the upper recesses of the nose. This membrane, called the olfactory mucosa, is where the virus first lands when it is inhaled. Within it are olfactory sensory neurons (OSNs), which are responsible for initiating smell sensations. They are tightly entwined with a kind of support cell called sustentacular cells.

In the new study, Belgian and German researchers claim that the virus infects sustentacular cells but not OSNs. "That is just a critical distinction," said the senior author Peter Mombaerts, who directs the Max Planck Research Unit for Neurogenetics in Frankfurt, Germany. "Once you believe that olfactory neurons can be infected, there is a quick route into the olfactory bulb and then you're in the brain already." The olfactory bulb, at the front of the brain, is where neural input about odors is first processed. If the virus penetrated this structure it could theoretically spread to deeper brain regions where it could do lasting damage -- especially since, unlike OSNs, most neurons are not regenerated once lost. But if the virus only infects the sustentacular cells, then the damage could be less long-lasting. Both pathways could explain the olfactory dysfunction that afflicts an estimated half of all Covid-19 patients. In one in 10 of those, the loss or change of smell is long-term, perhaps permanent. Mombaerts says this could be the result of support for the OSNs breaking down, even if they themselves are not infected. They may function below par, or stop functioning altogether, until the sustentacular cells regenerate.

Scientists identified a specific gene that doubles the risk of respiratory failure from Covid-19 and may go some way to explaining why some ethnic groups are more susceptible to severe disease than others. From a report: Researchers from the University of Oxford found that a higher-risk version of the gene most likely prevents the cells lining airways and the lungs from responding to the virus properly. About 60% of people with South Asian ancestry carry this version of the gene, compared with 15% of people with European heritage, according to the study published Thursday. The findings help explain why higher rates of hospitalization and death may have been seen in certain communities and on the Indian subcontinent. The authors cautioned that the gene cannot be used as a sole explanation as many other factors, such as socioeconomic conditions, play a role. Despite a significant impact from the virus to people with Afro-Caribbean ancestry, only 2% carry the higher-risk genotype. People with the gene, known as LZTFL1, would particularly benefit from vaccination, which remains the best method of protection, the authors said. The findings raise the possibility of research into treatments specific to patients with this gene, though no tailored drugs are currently available.

Google owner Alphabet has launched an artificial intelligence company to discover new drugs. From a report: UK-registered Isomorphic Labs will use technology from its sister company DeepMind to "to accelerate drug discovery, and ultimately, find cures for some of humanity's most devastating diseases," said Demis Hassabis, the head of DeepMind, in a blog post. He added that he would also become the chief executive of Isomorphic Labs. Scientists around the world were awed in July when DeepMind unveiled how its AlphaFold2 technology could be used to predict the shape of every protein in the human body with almost perfect accuracy.

DeepMind's model can solve one of the trickiest problems in biology by taking a sequence of amino acids and mapping the twists and turns of its shape. The algorithm could help replace or enhance painstaking laboratory work to identify the structures of proteins, which dictate how they behave. Pharmaceutical companies and academic researchers are eager to use the tool -- which DeepMind has made available on an open source basis -- to discover new targets for drugs. Its speed could cut the time to discovering innovative treatments, although the process of clinical trials is still likely to take several years. DeepMind said it would use the technology to try to find treatments for Chagas disease and Leishmaniasis, two of the most deadly diseases in the world.

Months-long silences. Mysterious rejections. Here's what's behind the shortages of a critical tool for ending the pandemic. ProPublica: A few weeks ago, a ProPublica reporter decided to test his kids for COVID-19. They had the sniffles, and with a grandparent set to visit he wanted to minimize the risk that they were infectious. This was the problem that quick, cheap COVID-19 tests were supposed to help fix. No need to go to a clinic or wait days for results. Just pick up a pack of tests at a local pharmacy whenever you want, swab your nose and learn within 15 minutes if you're likely to pass the virus along. So the ProPublican went to his neighborhood CVS, hoping to buy the required pack of two for $23.99. They were out of stock. Then he went to Rite Aid. They didn't have the tests either. Then Walgreens, then another CVS. All out of stock. The only supplier with a few tests to offer was his sister, who happened to have a few tucked away. It's a familiar experience for many Americans. But not for people in Britain, who get free rapid tests delivered to their homes on demand. Or France, Germany or Belgium, where at-home tests are ubiquitous and as cheap as a decent cappuccino. So why are at-home tests still so pricey and hard to find in the United States?

The answer appears to be a confounding combination of overzealous regulation and anemic government support -- issues that have characterized America's testing response from the beginning of the pandemic. Companies trying to get the Food and Drug Administration's approval for rapid COVID-19 tests describe an arbitrary, opaque process that meanders on, sometimes long after their products have been approved in other countries that prioritize accessibility and affordability over perfect accuracy. After the FDA put out a call for more rapid tests in the summer of 2020, Los Angeles-based biotech company WHPM, Inc. began working on one. They did a peer-reviewed trial following the agency's directions, then submitted the results this past March. In late May, WHPM head of international sales Chris Patterson said, the company got a confusing email from its FDA reviewer asking for information that had in fact already been provided. WHPM responded within two days. Months passed. In September, after a bit more back and forth, the FDA wrote to say it had identified other deficiencies, and wouldn't review the rest of the application. Even if WHPM fixed the issues, the application would be "deprioritized," or moved to the back of the line.

"We spent our own million dollars developing this thing, at their encouragement, and then they just treat you like a criminal," said Patterson. Meanwhile, the WHPM rapid test has been approved in Mexico and the European Union, where the company has received large orders. An FDA scientist who vetted COVID-19 test applications told ProPublica he became so frustrated by delays that he quit the agency earlier this year. "They're neither denying the bad ones or approving the good ones," he said, asking to remain anonymous because his current work requires dealing with the agency. FDA officials said they simply want to ensure that rapid tests detect even low levels of the virus, since false negative test results could cause people to unwittingly spread the disease. They blame the test shortages on an absence of the kind of sustained public funding that European governments have provided. Without it, manufacturers have lacked confidence that going through the FDA's process would be financially worth the trouble.

The first pill designed to treat symptomatic Covid has been approved by the UK medicines regulator. From a report: The tablet -- molnupiravir -- will be given twice a day to vulnerable patients recently diagnosed with the disease. In clinical trials the pill, originally developed to treat flu, cut the risk of hospitalisation or death by about half. Health Secretary Sajid Javid said the treatment was a "gamechanger" for the most frail and immunosuppressed. In a statement he said: "Today is a historic day for our country, as the UK is now the first country in the world to approve an antiviral that can be taken at home for Covid."

Molnupiravir, developed by the US drug companies Merck, Sharp and Dohme (MSD) and Ridgeback Biotherapeutics, is the first antiviral medication for Covid which can be taken as a pill rather than injected or given intravenously. The UK has agreed to purchase 480,000 courses with the first deliveries expected in November. Initially it will be given to both vaccinated and unvaccinated patients through a national study, with extra data on its effectiveness collected before any decision to order more. The drug needs to be given within five days of symptoms developing to be most effective. It's not immediately clear how it will be distributed so quickly by the NHS. It's thought some care homes may be offered supplies while other elderly or vulnerable patients may be prescribed it by their GP after testing positive for Covid.

On Monday, A group of diplomats from the United Kingdom proposed that the United Nations set up a group to develop new norms of international behavior in space, with the aim of preventing the kinds of misunderstandings that could lead to war. Wired reports: As spacefaring nations advance their military satellite capabilities, including being able to disrupt or damage other satellites, such provocative behavior could escalate already-tense diplomatic situations -- and create more space debris in low earth orbit, a crucial region that's already chock-full of derelict spacecraft. This is the first significant progress in developing space rules in more than four decades. The most important piece of space law, the Outer Space Treaty, was negotiated by the fledgling space powers in 1967.

Monday's vote before the UN's First Committee, which is focused on international security and disarmament, passed overwhelmingly, with representatives of 163 countries voting yea versus eight nays and nine abstentions. Considering the widespread support for the proposal, including backing from the Biden administration, Edmondson expects it to pass in the full UN General Assembly next month. The proposal would create a new working group at the UN that will meet twice a year in Geneva in 2022 and 2023. By the end of that time, the group must reach consensus on new rules and identify areas in need of further investigation. Crafting norms for the kinds of activities that escalate tensions or generate debris will likely be top priority for this group, says Cassandra Steer, an expert on space law and space security at the Australian National University in Canberra.

Joshua Chou writes via The Conversation: Last month the Australian Space Agency announced plans to send an Australian-made rover to the Moon by as early as 2026, under a deal with NASA. The rover will collect lunar soil containing oxygen, which could eventually be used to support human life in space. Although the deal with NASA made headlines, a separate mission conducted by private companies in Australia and Canada, in conjunction with the University of Technology Sydney, may see Australian technology hunting water on the Moon as soon as mid-2024. If all goes according to plan, it will be the first rover with Australian-made components to make it to the Moon.

The ten-kilogram rover, measuring 60x60x50cm, will be launched on board the Hakuto lander made by ispace, a lunar robotic exploration company based in Japan. The rover itself, also built by ispace, will have an integrated robotic arm created by the private companies Stardust Technologies (based in Canada) and Australia's EXPLOR Space Technology (of which I am one of the founders). Using cameras and sensors, the arm will collect high-resolution visual and haptic data to be sent back to the mission control centre at the University of Technology Sydney. It will also collect information on the physical and chemical composition of lunar dust, soil and rocks -- specifically with a goal of finding water. We know water is present within the Moon's soil, but we have yet to find a way to extract it for practical use.

An anonymous reader quotes a report from ScienceAlert: Originally, they were thought to be just specks of dust on a microscope slide. Now, a new study suggests that microchromosomes -- a type of tiny chromosome found in birds and reptiles -- have a longer history, and a bigger role to play in mammals than we ever suspected. By lining up the DNA sequence of microchromosomes across many different species, researchers have been able to show the consistency of these DNA molecules across bird and reptile families, a consistency that stretches back hundreds of millions of years. What's more, the team found that these bits of genetic code have been scrambled and placed on larger chromosomes in marsupial and placental mammals, including humans. In other words, the human genome isn't quite as 'normal' as previously supposed.

By tracing these microchromosomes back to the ancient Amphioxus, the scientists were able to establish genetic links to all of its descendants. These tiny 'specks of dust' are actually important building blocks for vertebrates, not just abnormal extras. It seems that most mammals have absorbed and jumbled up their microchromosomes as they've evolved, making them seem like normal pieces of DNA. The exception is the platypus, which has several chromosome sections line up with microchromosomes, suggesting that this method may well have acted as a 'stepping stone' for other mammals in this regard, according to the researchers. A tree chart outlining the presence of similar DNA in snakes, lizards, birds, crocodiles, and mammals. The study also revealed that as well as being similar across numerous species, the microchromosomes were also located in the same place inside cells. "It's not clear whether there's an evolutionary benefit to coding DNA in larger chromosomes or in microchromosomes, and the findings outlined in this paper might help scientists put that particular debate to rest -- although a lot of questions remain," adds ScienceAlert. "The study suggests that the large chromosome approach that has evolved in mammals isn't actually the normal state, and might be a disadvantage: genes are packed together much more tightly in microchromosomes, for example."

The findings have been published in the journal PNAS.

The Centers for Disease Control and Prevention has formally endorsed the Pfizer-BioNTech coronavirus vaccine for children aged 5 through 11, a move that will buttress defenses against a possible surge as winter arrives and ease the worries of tens of millions of pandemic-weary parents. From a report: At a meeting earlier in the day, a panel of scientific advisers had unanimously recommended that the vaccine be given to these children. Inoculations could begin as soon as this week. "Together, with science leading the charge, we have taken another important step forward in our nation's fight against the virus that causes Covid-19," Dr. Rochelle Walensky, director of the C.D.C., said in a statement Tuesday night. The C.D.C.'s endorsement arrives just as Americans prepare for a potentially risky holiday season. Cases in the United States have been falling steadily for weeks, but experts have warned that indoor gatherings may send the rates soaring again. Many Americans seem determined to celebrate; already airlines are bracing for what may be the busiest travel season since the start of the pandemic.

An anonymous reader quotes a report from Pro Publica: It's not a secret that industrial facilities emit hazardous air pollution. A new ProPublica analysis shows for the first time just how much toxic air pollution they emit -- and how much the chemicals they unleash could be elevating cancer risk in their communities. ProPublica's analysis of five years of modeled EPA data identified more than 1,000 toxic hot spots across the country and found that an estimated 250,000 people living in them may be exposed to levels of excess cancer risk that the EPA deems unacceptable.

The agency has long collected the information on which our analysis is based. Thousands of facilities nationwide that are considered large sources of toxic air pollution submit a report to the government each year on their chemical emissions. But the agency has never released this data in a way that allows the public to understand the risks of breathing the air where they live. Using the reports submitted between 2014 and 2018, we calculated the estimated excess cancer risk from industrial sources across the entire country and mapped it all. The EPA's threshold for an acceptable level of cancer risk is 1 in 10,000, meaning that of 10,000 people living in an area, there would likely be one additional case of cancer over a lifetime of exposure. But the agency has also said that ideally, Americans' added level of cancer risk from air pollution should be far lower, 1 in a million. Our map highlights areas where the additional cancer risk is greater than 1 in 100,000 -- 10 times lower than the EPA's threshold, but still high enough to be of concern, experts say. The map is interactive, allowing you to click on a hot spot to learn more about the industrial emissions there. You can also type in an address to find the increased estimated cancer risk at that location.

Climate change is revealing long-frozen artifacts and animals to archaeologists. But the window for study is slender and shrinking. From a report: Glacial archaeology is a relatively new discipline. The ice was literally broken during the summer of 1991 when German hikers in the Otztal Alps spotted a tea-colored corpse half-embedded on the Italian side of the border with Austria. Initially mistaken for a modern-day mountaineer killed in a climbing accident, Otzi the Iceman, as he came to be called, was shown through carbon-dating to have died about 5,300 years ago.

A short, comprehensively tattooed man in his mid-40s, Otzi wore a bearskin cap, several layers of clothing made of goat and deer hides, and bearskin-soled shoes stuffed with grass to keep his feet warm. The Iceman's survival gear included a longbow of yew, a quiver of arrows, a copper ax and a kind of crude first-aid kit full of plants with powerful pharmacological properties. A chest X-ray and a CT scan showed a flint arrowhead buried deep in Otzi's left shoulder, suggesting that he may have bled to death. His killing is humankind's oldest unsolved cold case. Six years later, in the Yukon's snow fields, hunting tools dating back thousands of years appeared from the melting ice. Soon, similar finds were reported in Western Canada, the Rockies and the Swiss Alps.

In 2006, a long, hot autumn in Norway resulted in an explosion of discoveries in the snowbound Jotunheimen mountains, home to the JÃtnar, the rock and frost giants of Norse mythology. Of all the dislodged detritus, the most intriguing was a 3,400-year-old proto-Oxford most likely fashioned out of reindeer hide. The discovery of the Bronze Age shoe signified the beginning of glacial surveying in the peaks of Innlandet County, where the state-funded Glacier Archaeology Program was started in 2011. Outside of the Yukon, it is the only permanent rescue project for discoveries in ice. Glacial archaeology differs from its lowland cousin in critical ways. G.A.P. researchers usually conduct fieldwork only within a short time frame from mid-August to mid-September, between the thaw of old snow and the arrival of new.

Starlink, part of Elon Musk's SpaceX company, has formed a subsidiary in India and is preparing to apply for licenses from the local government, according to a top official. From a report: "Pleased to share that SpaceX now has a 100% owned subsidiary in India," Sanjay Bhargava, India director for Starlink, said in a LinkedIn post Monday. Starlink's local India unit is registered with the name Starlink Satellite Communications Private Limited. A local unit is required for an internet company to offer its services in India, where Starlink -- assuming that it gets the license -- plans to offer 200,000 active terminals in over 160,000 districts by December 2022, the company representatives said. That's an ambitious goal for the company, which as of August had shipped 100,000 user terminals in 14 countries.

"NASA scientists have just published a commentary article in Nature calling for a framework for reporting extraterrestrial life to the world," reports Cosmos magazine (in an article shared by Slashdot reader Tesseractic): "Our generation could realistically be the one to discover evidence of life beyond Earth," write NASA Chief Scientist James Green and colleagues. "With this privileged potential comes responsibility. As life-detection objectives become increasingly prominent in space sciences, it is essential to open a community dialogue about how to convey information in a subject matter that is diverse, complicated and has a high potential to be sensationalised..."

Green and colleagues argue that...we should reframe such a discovery, so it isn't presented as a single moment when aliens are announced to the world. Instead, it should be seen as a progressive endeavour, reflecting the process of science itself. "If, instead, we recast the search for life as a progressive endeavour, we convey the value of observations that are contextual or suggestive but not definitive and emphasise that false starts and dead ends are an expected part of a healthy scientific process," they write. This will involve scientists, technologists and the media talking to each other to agree firstly on objective standards of evidence for life, and secondly on the best way to communicate that evidence.

This, they say, should preferably be done now before a detection of life is made, rather than scramble to put it together in the aftermath.
"The team kickstarts the conversation by proposing a 'confidence of life detection' (CoLD) scale, which contains seven steps taking us from first exciting potential detection of life to definitive confirmation," Cosmos points out. (With the stages including the discoveries of unquestionable biosignatures, a habitable environment, and then corroborating evidence.) Cosmos argues that "This is an increasingly important conversation to have — because experts think that the odds aliens exist are high."

And they close their article by quoting NASA's team. "Whatever the outcome of the dialogue, what matters is that it occurs. In doing so, we can only become more effective at communicating the results of our work, and the wonder associated with it."

An anonymous reader quotes a report from The Hill: A new study from the [CDC] finds that vaccination provides better protection against hospitalization with COVID-19 than a previous infection with the virus. The analysis found people hospitalized with coronavirus-like symptoms were more than five times more likely to test positive for COVID-19 if they had had recent prior infection than if they were recently vaccinated. The study released Friday examined more than 7,000 people across nine states and 187 hospitals, comparing those who were unvaccinated and had previously had the coronavirus in the last three to six months and those who were vaccinated over the same time frame.

The CDC urged even those who were previously infected to get their shots. [...] Overall, [CDC Director Rochelle Walensky] said at a press briefing earlier this week that the hospitalization rate among unvaccinated people is 12 times higher than for vaccinated people. The vaccination rate for those 12 and older has now reached 78 percent with at least one shot, but Walensky noted that still leaves more than 60 million eligible Americans unvaccinated.

NASA is calling on any interested humans to contribute to the machine learning algorithms that help Perseverance get around. All you need to do is look at some images and label geological features. ExtremeTech reports: The project is known as AI4Mars, and it's a continuation of a project started last year using images from Curiosity. That particular rover arrived on Mars in 2012 and has been making history ever since. NASA used Curiosity as the starting point when designing Perseverance. The new rover has 23 cameras, which capture a ton of visual data from Mars, but the robot has to rely on human operators to interpret most of those images. The rover has enhanced AI to help it avoid obstacles, and it will get even better if you chip in.

The AI4Mars site lets you choose between Opportunity, Curiosity, and the new Perseverance images. After selecting the kind of images you want to scope out, the site will provide you with several different marker types and explanations of what each one is. For example, the NavCam asks you to ID sand, consolidated soil (where the wheels will get good traction), bedrock, and big rocks. There are examples of all these formations, so it's a snap to get started.

Nasa's Juno mission, the solar-powered robotic explorer of Jupiter, has completed its five-year prime mission to reveal the inner workings of the Solar System's biggest planet. The most recent findings from these measurements have now been published in a series of papers, revealing the three-dimensional structure of Jupiter's weather systems -- including of its famous Great Red Spot, a centuries-old storm big enough to swallow the Earth whole. The Conversation reports: Jupiter's Great Red Spot has had a hard time in recent years. [...] But fans of the storm can take comfort from Juno's latest findings. In 2017, Juno was able to observe the red spot in microwave light. Then, in 2019, as Juno flew at more than 200,000 kilometers per hour above the vortex, Nasa's Deep Space Network was monitoring the spacecraft's velocity from millions of kilometers away. Tiny changes as small as 0.01 millimeters per second were detected, caused by the gravitational force from the massive spot. By modeling the microwave and gravity data, my colleagues and I were able to determine that the famous storm is at least 300 km (186 miles) deep, maybe as deep as 500 km (310 miles). That's deeper than the expected cloud-forming "weather layer" that reaches down to around 65 km (40 miles) below the surface, but higher than the jet streams that might extend down to 3,000 km (1,864 miles). The deeper the roots, the more likely the Red Spot is to persist in the years to come, despite the superficial battering it has been receiving from passing storms. To place the depth in perspective, the International Space Station orbits ~420 km (260 miles) above Earth's surface. Yet despite these new findings, the spot could still be a "pancake-like" structure floating in the bottomless atmosphere, with the spot's 12,000 km (7,456 mile) width being 40 times larger than its depth.

In the cloud-forming weather layer, Juno's microwave antennae saw the expected structure of belts and zones. The cool zones appeared dark, indicating the presence of ammonia gas, which absorbs microwave light. Conversely, the belts were bright in microwave light, consistent with a lack of ammonia. These bright and dark bands in the weather layer were perfectly aligned with the winds higher up, measured at the top of the clouds. But what happens when we probe deeper? The temperature of Jupiter's atmosphere is just right for the formation of a water cloud around 65 km (40 miles) down below the cloud tops. When Juno peered through this layer, it found something unexpected. The belts became microwave-dark, and the zones became microwave-bright. This is the complete reverse of what we saw in the shallower cloudy regions, and we are calling this transition layer the "jovicline" -- some 45-80 km (28-50 miles) below the visible clouds. [...] The jovicline may separate the shallow cloud-forming weather layer from the deep abyss below. This unexpected result implies something is moving all that ammonia around.

One possibility is that each jet stream is associated with a "circulation cell," a climate phenomenon that moves gases around via currents of rising and falling air. The rising could cause ammonia enrichment, and the sinking ammonia depletion. If true, there would be about eight of these circulation cells in each hemisphere. [...] Other meteorological phenomena might be responsible for moving the ammonia around within this deep atmosphere. For example, vigorous storms in Jupiter's belts might create mushy ammonia-water hailstones (known as "mushballs"), which deplete ammonia within the shallow belts before falling deep, eventually evaporating to enrich the belts at great depths.

The Pacific lingcod is an ill-tempered, omnivorous fish with a mouth like a messy silverware drawer, its 500-plus teeth arranged haphazardly on two sets of highly mobile jaws. New research, published this month in the scientific journal Proceedings of the Royal Society B, reveals that the Pacific lingcod gains and loses an average of 20 teeth every day. From a report: If humans had the same dental scheme, we'd replace a tooth daily. "Kind of makes braces useless," says Adam Summers, professor of biology at the University of Washington and co-author of the study. "And brushing." The Pacific lingcod's rate of tooth replacement came as a surprise to researchers, says study co-author Karly Cohen, a PhD student at the University of Washington studying the biomechanics of feeding.

"The existing research we have on tooth replacement comes from oddballs," Cohen says, such as anglerfish that grow teeth on their foreheads, or the piranha, which can lose a quarter of its teeth at a time. "But most fish have teeth like lingcod. And so it could very well be that most fishes are losing mass amounts of their teeth daily" and replacing them quickly, like this species, she adds. The Pacific lingcod is an ornery sportfish about four feet long at adulthood, an ambush predator that frequently indulges in cannibalism. It's found on the North American west coast, from Alaska to Baja California, Mexico, and it's economically important to fishers in part because it's "great in a taco," Cohen says.

Scientists have discovered a new phase of water -- adding to liquid, solid and gas -- know as "superionic ice." The "strange black" ice, as scientists called it, is normally created at the core of planets like Neptune and Uranus. From a report: In a study published in Nature Physics, a team of scientists co-led by Vitali Prakapenka, a University of Chicago research professor, detailed the extreme conditions necessary to produce this kind of ice. It had only been glimpsed once before, when scientists sent a massive shockwave through a droplet of water, creating superionic ice that only existed for an instant. In this experiment, the research team took a different approach. They pressed water between two diamonds, the hardest material on Earth, to reproduce the intense pressure that exists at the core of planets. Then, they used the Advanced Photon Source, or high-brightness X-ray beams, to shoot a laser through the diamonds to heat the water, according to the study.

"Imagine a cube, a lattice with oxygen atoms at the corners connected by hydrogen when it transforms into this new superionic phase, the lattice expands, allowing the hydrogen atoms to migrate around while the oxygen atoms remain steady in their positions," Prakapenka said in a press release. "It's kind of like a solid oxygen lattice sitting in an ocean of floating hydrogen atoms." Using an X-ray to look at the results, the team found the ice became less dense and was described as black in color because it interacted differently with light. "It's a new state of matter, so it basically acts as a new material, and it may be different from what we thought," Prakapenka said.

Predicting the next word someone might say -- like AI algorithms now do when you search the internet or text a friend -- may be a key part of the human brain's ability to process language, new research suggests. From a report: How the brain makes sense of language is a long-standing question in neuroscience. The new study demonstrates how AI algorithms that aren't designed to mimic the brain can help to understand it. "No one has been able to make the full pipeline from word input to neural mechanism to behavioral output," says Martin Schrimpf, a Ph.D. student at MIT and an author of the new paper published this week in PNAS.

The researchers compared 43 machine-learning language models, including OpenAI's GPT-2 model that is optimized to predict the next words in a text, to data from brain scans of how neurons respond when someone reads or hears language. They gave each model words and measured the response of nodes in the artificial neural networks that, like the brain's neurons, transmit information. Those responses were then compared to the activity of neurons -- measured with functional magnetic resonance (fMRI) or electrocorticography -- when people performed different language tasks. The activity of nodes in the AI models that are best at next-word prediction was similar to the patterns of neurons in the human brain. These models were also better at predicting how long it took someone to read a text -- a behavioral response. Models that exceled at other language tasks -- like filling in a blank word in a sentence -- didn't predict the brain responses as well.

Female California condors don't need males to have offspring -- joining sharks, rays, and lizards on the list of creatures that can reproduce without mating. From a report: "There's something really confusing about the condor data." Those weren't the words Oliver Ryder wanted to hear as he walked to his car after a long day's work trying to save California condors, one of the most endangered animals on the planet. When his colleague Leona Chemnick explained what she was seeing, his dread quickly changed to fascination. For decades, scientists have been trying to coax the California condor back from the edge of extinction. The entire population of these birds crashed to just 22 animals in 1982. By 2019, captive breeding and release efforts had slowly built the total population up over 500. Doing that has required careful management of captive birds, particularly selecting which males and females can breed to produce healthy offspring. That's how, as the scientists took a closer at genetic data, they discovered that two male birds -- known only by their studbook numbers, SB260 and SB517 -- showed no genetic contribution from the birds that should have been their fathers.

In other words, the birds came into the world by facultative parthenogenesis -- or virgin birth -- according to a peer-reviewed paper published October 28 in the Journal of Heredity. Such asexual reproduction in normally sexually reproducing species occurs when certain cells produced with a female animal's egg behave like sperm and fuse with the egg. Though rare in vertebrates, parthenogenesis occurs in sharks, rays, and lizards. Scientists have also recorded self-fertilization in some captive bird species, such as turkeys, chickens, and Chinese painted quail, usually only when females are housed without access to a male. But this is the first time it's been recorded in California condors.

A major solar flare erupted from the sun on Thursday in the strongest storm yet of our star's current weather cycle. Space.com reports: The sun fired off an X1-class solar flare, its most powerful kind of flare, that peaked at 11:35 a.m. EDT (1535 GMT), according to an alert from the U.S. Space Weather Prediction Center (SWPC), which tracks space weather events. The flare caused a temporary, but strong, radio blackout across the sunlit side of Earth centered on South America, the group wrote in an statement. NASA officials called the solar eruption a "significant solar flare," adding that it was captured in real-time video by the space agency's Solar Dynamics Observatory.

A coronal mass ejection from the flare, a huge eruption of charged particles, could reach Earth by Saturday or Sunday (Oct. 30-31), just in time for Halloween, SpaceWeather.com reported. The eruption could supercharge Earth's northern lights and potentially interfere with satellite-based communications. [...] Thursday's flare appeared to also spawn a coronal mass ejection, SWPC officials said. [...] The sun is in the early days of its current solar activity cycle, each of which lasts 11 years. The current cycle, called solar cycle 25, began in December 2019.

An anonymous reader quotes a report from IEEE Spectrum: In a new study, researchers temporarily made the blood-brain barrier more permeable, allowing a monoclonal antibody to target cancer that had spread to the brain. Scientists made it possible for the drug to cross the barrier -- a protective membrane which prevents most larger molecules from entering the brain -- using focused ultrasound beams guided by magnetic resonance imaging (MRI). Though there has been promising research on the technique, it had never been used to deliver a drug to the brain. Scientists also used a system of radioactive tagging to show that more of the drug had reached the tumors. No patient had notable side effects from the treatment. Though the study was preliminary, it could open the door to treating a whole range of diseases impacting the brain.

In the study, four patients with a type of metastatic breast cancer, Her2-positive, first received a treatment of trastuzumab, a common monoclonal antibody treatment also called Herceptin. Collectively, the patients received 20 treatments -- up to six each. The ultrasound therapy took place inside a high-resolution MRI scanner that the researchers used to target the treatment. The researchers used a hemispheric helmet with 1024 ultrasound transducers to deliver the ultrasound, targeting it by both moving the helmet and adjusting the voltage across individual transducers, causing a slight difference in the phase of the ultrasound that can correct for variations in the thickness of the skull. [...]

While the ultrasound was delivered, the patients were also receiving an infusion of lipid-based microbubbles. In combination with targeted ultrasound, the microbubbles produce the temporary permeability of the blood-brain barrier. Scientists still don't entirely know why this is. In the 1950s, researchers started to notice that ultrasound seemed to break down the blood-brain barrier. Hynynen came across these early studies while doing cancer research and started to try the technique to make the barrier more permeable. But in animal studies, using only ultrasound didn't consistently avoid injury. Only when the researchers tried using microbubbles did they avoid inflicting damage.

Covid-19 cases and deaths are climbing across the world for the first time in two months as the virus surges across Europe, World Health Organization officials said at a briefing Thursday. From a report: After weeks of decline, infections in Europe have risen over the last three consecutive weeks, even as cases fall in every other region across the world, according to WHO. There were nearly 3 million new Covid cases reported worldwide for the week ended Sunday, an increase of 4% from the previous seven days, according to WHO's most recent epidemiological update. Globally, Covid cases had fallen 4% the week before, despite a 7% increase across Europe over that same period. Cases in Europe surged by 18% over the last week alone, WHO data shows.

"The global number of reported cases and deaths from Covid-19 is now increasing for the first time in two months, driven by an ongoing rise in Europe that outweighs declines in other regions," WHO Director-General Dr. Tedros Adhanom Ghebreyesus said. "It's another reminder that the Covid-19 pandemic is far from over." Covid has surged sharply in Czechia and Hungary, where the seven-day average of cases swelled more than 100% from the previous week as of Wednesday, according to a CNBC analysis of data from Johns Hopkins University. Croatia, Denmark, Norway and Poland each recorded weekly average case increases of more than 70% on Wednesday, JHU found.

An anonymous reader quotes a report from The Associated Press: A cheap antidepressant reduced the need for hospitalization among high-risk adults with COVID-19 in a study hunting for existing drugs that could be repurposed to treat coronavirus. Researchers tested the pill used for depression and obsessive-compulsive disorder because it was known to reduce inflammation and looked promising in smaller studies. They've shared the results with the U.S. National Institutes of Health, which publishes treatment guidelines, and they hope for a World Health Organization recommendation. The pill, called fluvoxamine, would cost $4 for a course of COVID-19 treatment. By comparison, antibody IV treatments cost about $2,000 and Merck's experimental antiviral pill for COVID-19 is about $700 per course.

Researchers tested the antidepressant in nearly 1,500 Brazilians recently infected with coronavirus who were at risk of severe illness because of other health problems, such as diabetes. About half took the antidepressant at home for 10 days, the rest got dummy pills. They were tracked for four weeks to see who landed in the hospital or spent extended time in an emergency room when hospitals were full. In the group that took the drug, 11% needed hospitalization or an extended ER stay, compared to 16% of those on dummy pills. The results, published Wednesday in the journal Lancet Global Health, were so strong that independent experts monitoring the study recommended stopping it early because the results were clear. Questions remain about the best dosing, whether lower risk patients might also benefit and whether the pill should be combined with other treatments.

In a project that could unlock the world's research papers for easier computerized analysis, an American technologist has released online a gigantic index of the words and short phrases contained in more than 100 million journal articles -- including many paywalled papers. Nature reports: The catalogue, which was released on October 7 and is free to use, holds tables of more than 355 billion words and sentence fragments listed next to the articles in which they appear. It is an effort to help scientists use software to glean insights from published work even if they have no legal access to the underlying papers, says its creator, Carl Malamud. He released the files under the auspices of Public Resource, a non-profit corporation in Sebastopol, California that he founded. Malamud says that because his index doesn't contain the full text of articles, but only sentence snippets up to five words long, releasing it does not breach publishers' copyright restrictions on the re-use of paywalled articles. However, one legal expert says that publishers might question the legality of how Malamud created the index in the first place.

Some researchers who have had early access to the index say it's a major development in helping them to search the literature with software -- a procedure known as text mining. [...] Computer scientists already text mine papers to build databases of genes, drugs and chemicals found in the literature, and to explore papers' content faster than a human could read. But they often note that publishers ultimately control the speed and scope of their work, and that scientists are restricted to mining only open-access papers, or those articles they (or their institutions) have subscriptions to. Some publishers have said that researchers looking to mine the text of paywalled papers need their authorization. And although free search engines such as Google Scholar have -- with publishers' agreement -- indexed the text of paywalled literature, they only allow users to search with certain types of text queries, and restrict automated searching. That doesn't allow large-scale computerized analysis using more specialized searches, Malamud says.

An anonymous reader quotes a report from the BBC: A new chapter in physics has opened, according to scientists who have been searching for a vital building block of the Universe. A major experiment has been used to search for an elusive sub-atomic particle: a key component of the matter that makes up our everyday lives. The search failed to find the particle, known as the sterile neutrino. This will now direct physicists towards even more interesting theories to help explain how the Universe came to be. Prof Mark Thomson, the executive chair of the Science and Technology Facilities Council (STFC), which funds the UK's contribution to the Microboone experiment, described the result as ''pretty exciting'." That is because a sizeable proportion of physicists have been developing their theories on the basis that the existence of the sterile neutrino was a possibility.

Dr Sam Zeller from Fermilab says that the non-detection does not have to contradict previous findings. "The earlier data doesn't lie," she said. "There's something really interesting happening that we still need to explain. Data is steering us away from the likely explanations and pointing toward something more complex and interesting, which is really exciting." Prof Justin Evans, from the University of Manchester, believes that the puzzle posed by the latest findings marks a turning point in neutrino research. "Every time we look at neutrinos, we seem to find something new or unexpected," he said. "Microboone's results are taking us in a new direction, and our neutrino program is going to get to the bottom of some of these mysteries."

According to updated CDC guidelines, people with compromised immune systems may get a fourth mRNA COVID-19 shot. CNN reports: The CDC authorized a third dose for certain immunocompromised people 18 and older in August. It said a third dose, rather than a booster -- the CDC makes a distinction between the two -- was necessary because the immunocompromised may not have had a complete immune response from the first two doses. A study from Johns Hopkins University this summer showed that vaccinated immunocompromised people were 485 times more likely to end up in the hospital or die from Covid-19 compared to most vaccinated people. In small studies, the CDC said, fully vaccinated immunocompromised people accounted for about 44% of the breakthrough cases that required hospitalization. People who are immunocompromised are also more likely to transmit the virus to people who had close contact with them. The US Food and Drug Administration has also authorized booster shots of all three available vaccines for certain people and that would include the immune compromised, the CDC says.

Research showed that a booster dose enhanced the antibody response to the vaccine in certain immunocompromised people. That would make for a fourth shot at least six months after completing the third mRNA vaccine dose. At this time, the CDC does not have a recommendation about the fourth shot. People should talk to their doctors to determine if it is necessary, the CDC says. People who are immunocompromised who got the single-dose Johnson & Johnson shot should get a booster at least two months after their initial vaccine. People who choose a Moderna vaccine as a booster, even if they received a different vaccine as the first dose, should get the half-dose sized shot that was authorized as a booster for Moderna's vaccine, the CDC said.

A solution to P vs NP could unlock countless computational problems -- or keep them forever out of reach. MIT Technology Review: On Monday, July 19, 2021, in the middle of another strange pandemic summer, a leading computer scientist in the field of complexity theory tweeted out a public service message about an administrative snafu at a journal. He signed off with a very loaded, "Happy Monday." In a parallel universe, it might have been a very happy Monday indeed. A proof had appeared online at the esteemed journal ACM Transactions on Computational Theory, which trades in "outstanding original research exploring the limits of feasible computation." The result purported to solve the problem of all problems -- the Holy Grail of theoretical computer science, worth a $1 million prize and fame rivaling Aristotle's forevermore.

This treasured problem -- known as "P versus NP" -- is considered at once the most important in theoretical computer science and mathematics and completely out of reach. It addresses questions central to the promise, limits, and ambitions of computation, asking:

Why are some problems harder than others?
Which problems can computers realistically solve?
How much time will it take?

And it's a quest with big philosophical and practical payoffs. "Look, this P versus NP question, what can I say?" Scott Aaronson, a computer scientist at the University of Texas at Austin, wrote in his memoir of ideas, Quantum Computing Since Democritus. "People like to describe it as 'probably the central unsolved problem of theoretical computer science.' That's a comical understatement. P vs NP is one of the deepest questions that human beings have ever asked." One way to think of this story's protagonists is as follows: "P" represents problems that a computer can handily solve. "NP" represents problems that, once solved, are easy to check -- like jigsaw puzzles, or Sudoku. Many NP problems correspond to some of the most stubborn and urgent problems society faces. The million-dollar question posed by P vs. NP is this: Are these two classes of problems one and the same? Which is to say, could the problems that seem so difficult in fact be solved with an algorithm in a reasonable amount of time, if only the right, devilishly fast algorithm could be found? If so, many hard problems are suddenly solvable. And their algorithmic solutions could bring about societal changes of utopian proportions -- in medicine and engineering and economics, biology and ecology, neuroscience and social science, industry, the arts, even politics and beyond.

AleRunner writes: The United Kingdom's COVID-19 death rate has reached its highest rate since just after the peak of the last lockdown in March. This has been happening as the new AY.4.2 variant of the Delta strain of the SARS-COV-2 virus has begun to dominate in the UK. Coming into winter, the increase in coronavirus infection in the UK is already causing a collapse in health care with patients dying just after long waits for care or even whilst waiting. Although there's some similarity to 2020, and a worry that AY.4.2 might avoid immunity, the UK chancellor has decided to commit to a vaccines mainly strategy whilst other countries seem to be unconcerned with the CDC already declaring that no measures are planned to limit AY.4.2 spread.

Blue Origin, the rocket and space tourism company founded by Jeff Bezos, is proposing a massive new commercial space station called "Orbital Reef" that could be used to host science experiments, vacation getaways, and potentially even in-space manufacturing. CNN reports: The company plans to work alongside startup Sierra Space to bring the space station to fruition, and Boeing plans to design a research module on the station, though there are no guarantees the companies can make it happen. Such projects are still exorbitantly expensive and risky, likely costing in the tens of billions of dollars and requiring multiple safe launches before a human ever even floats aboard. Blue Origin and Sierra Space plan to co-finance the space station, though executives declined to give an all-in cost estimate during a press conference Monday. They did add that they are expecting to sign on NASA as an anchor tenant, though it's not exactly clear how such a partnership could take shape.

Blue Origin hopes Orbital Reef could be operational in the late 2020s, though it will have to get quite a bit done to make that happen. The company has only managed a few crewed suborbital flights so far, much like NASA first achieved back in the early 1960s, and it has yet to put a spacecraft in orbit, let alone a person. A space station would take a major leap. New Glenn, the Blue Origin-built rocket that is expected to be powerful and large enough to haul the biggest portions of the space station to orbit, is not yet operational, and its maiden flight was recently delayed to at least late 2022. The orbital reef will be able to host up to 10 people and will have roughly the same internal volume as the ISS.

A possible Saturn-sized planet identified in the distant Whirlpool Galaxy could be the first exoplanet to be detected outside the Milky Way. From a report: The exoplanet candidate appears to be orbiting an X-ray binary -- made up of a normal star and a collapsed star or black hole -- with its distance from this binary roughly equivalent to the distance of Uranus from the sun. The discovery opens up a new window to search for exoplanets -- planets orbiting stars beyond our Sun -- at greater distances than ever before. Although nearly 5,000 exoplanets have been detected so far, all of them are in the Milky Way galaxy -- with few further than about 3,000 light years from Earth.

An exoplanet in the spiral Messier 51 (M51) galaxy -- also called the Whirlpool Galaxy because of its distinctive shape -- would be about 28m light years away. Dr Rosanne Di Stefano of the Center for Astrophysics at Harvard and Smithsonian in Cambridge, US, who led the research, said: "Since the 1750s, it has been conjectured that the dim distant nebulas, now called galaxies, are island universes: large, gravitationally-bound stellar populations similar to our home, the Milky Way. Our discovery of the planet candidate ... gives us the first peek into external populations of planetary systems, extending the reach of planet searches to distances roughly 10,000 times more distant."

An anonymous reader quotes a report from TechCrunch: After already targeting verticals like hotels and apartment complexes, Amazon announced today it's now rolling out new solutions for healthcare providers and senior living centers. The solutions, which are a part of Alexa Smart Properties, are designed specifically to meet the needs of deploying Alexa devices at scale and will allow the facility's administrators to create customized experiences for their residents or patients. In senior living centers, the residents would be able to use Alexa devices to call their family members and other loved ones, as well as keep up with the goings-on at their community and other community news. The devices could also be used to make announcements, allow the residents to communicate with each other through direct audio messages and make voice and video calls, and they can streamline other center activities -- like check-ins, maintenance requests and various administrative tasks. Amazon believes this could help make facilities more efficient and productive. Amazon says senior living communities include Atria and Eskaton will integrate with its new solution.

With Amazon's new solution for hospitals, patients will be able to use Alexa to communicate with care staff, control the devices in their room, and stay entertained with news and music. Healthcare providers can also communicate with their patients using Alexa features like calling and Drop-In, without having to enter the patient rooms. This could also help hospitals be more productive and conserve their medical supplies and protective equipment like gloves, masks and gowns, notes Amazon. (PPE shortages had been an ongoing issue in some locations as COVID spiked during the pandemic.) Though Amazon has struggled with privacy issues related to its use of voice recordings and transcriptions, the healthcare and senior living center solutions will not save the voice recordings and don't require users to share personal info with Alexa to use the device, the company explains. Users can also mute the Echo's microphone at any time with the button on top. Amazon also claims it safeguards protected health information received through HIPAA-eligible Alexa skill interactions. Both of the new Alexa Smart Properties solutions will roll out in the U.S. starting next month, Amazon says.

An anonymous reader quotes a report from The Debrief: How do we how know to speak and to read? These essential questions led to new research from the Massachusetts Institute of Technology that uses AI models to examine how and why our brains understand language. Oddly enough, your brain may work just like your smartphone's autocorrect feature. The new study, published in the Proceedings of the National Academy of Sciences, shows that the function of these AI language models resembles the method of language processing in the human brain, suggesting that the human brain may use next-word prediction to drive language processing.

In this new study, a team of researchers at MIT analyzed 43 different language models, many of which were optimized for next-word prediction. These models include the GPT-3 (Generative Pre-trained Transformer 3), which can generate realistic text when given a prompt, or other ones designed to provide a fill-in-the-blanks function. Researchers presented each model with a string of words to measure the activity of its neural nodes. They then compared these patterns to activity in the human brain, measured when test subjects performed language tasks like listening, reading full sentences, and reading one word at a time. The study showed that the best performing next-word prediction models had activity patterns that bore the most resemblance to those of the human brain. In addition, activity in those same models also correlated with human behavioral measures, such as how fast people could read the text.

The new study results suggest that next-word prediction is one of the key functions in language processing, supporting a previously proposed hypothesis but has yet to be confirmed. Scientists have not found any brain circuits or mechanisms that conduct that type of processing. Moving forward, the researchers plan to build variants of the next-word prediction models to see how small changes between each model affect their processing ability. They also plan to combine these language models with computer models developed to perform other brain-like tasks, such as perception of the physical world.

Time was found to flow differently between the top and bottom of a single cloud of atoms. Physicists hope that such a system will one day help them combine quantum mechanics and Einstein's theory of gravity. From a report: The infamous twin paradox sends the astronaut Alice on a blazing-fast space voyage. When she returns to reunite with her twin, Bob, she finds that he has aged much faster than she has. It's a well-known but perplexing result: Time slows if you're moving fast. Gravity does the same thing. Earth -- or any massive body -- warps space-time in a way that slows time, according to Albert Einstein's general theory of relativity. If Alice lived her life at sea level and Bob at the top of Everest, where Earth's gravitational pull is slightly weaker, he would again age faster. The difference on Earth is modest but real -- it's been measured by putting atomic clocks on mountaintops and valley floors and measuring the difference between the two.

Physicists have now managed to measure this difference to the millimeter. In a paper posted earlier this month to the scientific preprint server arxiv.org, researchers from the lab of Jun Ye, a physicist at JILA in Boulder, Colorado, measured the difference in the flow of time between the top and the bottom of a millimeter-tall cloud of atoms. The work is a step toward studying physics at the intersection of general relativity and quantum mechanics, two theories that are famously incompatible. The new clock takes a fundamentally quantum system -- an atomic clock -- and intertwines it with gravity's pull. In the experiment, Ye's team used an optical lattice clock, a cloud of 100,000 strontium atoms that can get tickled by a laser. If the laser's frequency is just right, the electrons orbiting each atom will be excited to a higher, more energetic orbit. Because only a tiny range of laser frequencies motivate the electrons to move, measuring this frequency provides an extremely precise measurement of time. It's like a quantum grandfather clock, where the ticking comes from the oscillations of the laser light rather than the swing of a pendulum.

"A star located 60 million light years away went supernova last year, and astronomers managed to capture all stages of the stellar explosion using telescopes both on the ground and in space," reports Gizmodo.

Long-time Slashdot reader spaceman375 shared Gizmodo's report: This awesome display of astronomical power has yielded a dataset of unprecedented proportions, with independent observations gathered before, during, and after the explosion. It's providing a rare multifaceted view of a supernova during its earliest phase of destruction. The resulting data should vastly improve our understanding of the processes involved when stars go supernova, and possibly lead to an early warning system in which astronomers can predict the timing of such events.

"We used to talk about supernova work like we were crime scene investigators, where we would show up after the fact and try to figure out what happened to that star," Ryan Foley, an astronomer at the University of California, Santa Cruz, and the leader of the investigation, explained in a press release. "This is a different situation, because we really know what's going on and we actually see the death in real time."

Of course, it took 60 million years for the light from this supernova to reach Earth, so it's not exactly happening in "real time," but you get what Foley is saying... Observations of circumstellar material in close proximity to the star were made by Hubble just hours after the explosion, which, wow. The star shed this material during the past year, offering a unique perspective of the various stages that occur just prior to a supernova explosion. "We rarely get to examine this very close-in circumstellar material since it is only visible for a very short time, and we usually don't start observing a supernova until at least a few days after the explosion," said Samaporn Tinyanont, the lead author of the paper, which is set for publication in the Monthly Notices of the Royal Astronomical Society. TESS managed to capture one image of the evolving system every 30 minutes, starting a few days before the explosion and ending several weeks afterward. Hubble joined in on the action a few hours after the explosion was first detected. Archival data dating back to the 1990s was also brought in for the analysis, resulting in an unprecedented multi-decade survey of a star on its way out...

In the press release, the researchers referred to SN 2020fqv as the "Rosetta Stone of supernovas," as the new observations could translate hidden or poorly understood signals into meaningful data.

NASA's Perseverance rover has recorded up to five hours of sounds on the Mars, giving engineers a sense of how the Red Planet sounds different from Earth. Space.com reports: NASA now has a Perseverance rover website filling up with Martian audio, ranging from wind gusts to the sounds of rover driving as it seeks spots to hunt for the signs of life on the Red Planet. In March, we even heard its laser "snapping" (sadly, no pew-pew noise was evident.)

"It's like you're really standing there," Baptiste Chide, a planetary scientist who studies data from the Perseverance microphones, said in a statement from NASA's Jet Propulsion Laboratory (JPL). "Martian sounds have strong bass vibrations, so when you put on headphones, you can really feel it. I think microphones will be an important asset to future Mars and solar system science," added Chide, who works at France's Institute of Research in Astrophysics and Planetology. The SuperCam mics have been especially helpful for JPL to learn more about the environment in Jezero Crater, where Perseverance has been roaming for about seven Earth months. In May, Perseverance was able to hear the sound of the Ingenuity drone's rotors buzzing from a distance of 262 feet away. "The audio has been useful for investigations ranging from how sound propagates on Mars, and keeping Perseverance well-maintained," the report adds.

An anonymous reader shares a report: It's safe to assume that few Pornhub visitors are looking for hour-long calculus videos (by a fully-clothed instructor), but Taiwanese math teacher Changhsu puts them there anyway. His channel is filled with over 200 decidedly unsexy chalkboard lessons about topics like differential equations. The 34-year-old math tutor found the YouTube market for math explainers to be saturated, so he decided to expand his reach into Pornhub. He told Mel Magazine that he wants to reach a new market of mathematics learners.

Does a meme a day keep the doctor away? Not quite, but it looks like it might help, according to one recent study. From a report: Researchers with Pennsylvania State University and the University of California Santa Barbara found that memes helped people cope with life during the COVID-19 pandemic, according to a study published this week in the Psychology of Popular Media journal. Researchers found that those who viewed memes -- a type of humor they described as funny or cute pictures that reference pop culture -- reported "higher levels of humor" and more positive feelings, according to a news release from the American Psychological Association, which publishes the journal.

They surveyed 748 people online last December: 72% of those who responded were white, 54% identified as women, 63% didn't hold a college degree, and their ages ranged from 18 to 88, the release states. They were shown a variety of meme types, with different kinds of photos and captions, and asked to rate the cuteness, humor and emotional responses prompted by the materials, as well as how much the memes in question made them think about COVID-19. Those who viewed memes that specifically referenced the pandemic felt less stress than those who viewed non-pandemic-related memes. They also felt more capable of coping with the COVID-19 crisis and were better at processing information, according to the study. And they were also less likely to be stressed about the pandemic than those who didn't view memes related to COVID-19 at all, researchers concluded.

India has administered 1 billion doses of COVID-19 vaccine, officials said Thursday, passing a milestone for the South Asian country where the delta variant fueled its first crushing surge earlier this year. From a report: About 75% of India's total eligible adult population have received at least one dose, while around 30% are fully immunized. The country of nearly 1.4 billion people is the second to exceed a billion cumulative doses after the most populous country China did so in June. Coronavirus cases have fallen sharply in India since the devastating months at the start of the year when the highly transmissible delta variant, first detected in the country a year ago, was infecting hundreds of thousands daily, sending COVID-19 patients into overwhelmed hospitals and filling cremation grounds. Officials have bolstered the vaccination campaign in recent months, which experts say have helped control the outbreak since. The country began its drive in January. Still, there remains a worrying gap between those who have received one shot and those fully immunized. Ramping up the second dose is "an important priority," V K Paul, the head of the country's COVID-19 taskforce, said at a briefing last week.

Nanoracks, Voyager Space and Lockheed Martin announced today (Oct. 21) that they plan to get a free-flying private space station up and running in low Earth orbit (LEO) by 2027. Space.com reports: The outpost, called Starlab, is envisioned to be a tourist destination as well as a research and manufacturing hub that helps foster the growth of an off-Earth economy. "To meet U.S. government, international space agency and commercial needs in space, these industry leaders will develop Starlab specifically to enable the growing space economy and meet pent-up customer demand for space services such as materials research, plant growth and astronaut activity," the three companies said in a press release.

The four-person Starlab station will be lofted in a single launch, which is expected to take place in 2027. The outpost will feature a habitat module with 12,000 cubic feet (340 cubic meters) of internal volume, a power and propulsion element, a laboratory setup and a large external robotic arm to service payloads and cargo, according to Nanoracks' Starlab page. For comparison, the International Space Station (ISS) has 32,333 cubic feet (916 cubic meters) of internal volume, which is equivalent to that of a Boeing 747 jet.