With the new coronavirus coronavirus spreading from person to person (possibly including from people without symptoms), reaching four continents, and traveling faster than SARS, driving it out of existence is looking increasingly unlikely. From a report: It's still possible that quarantines and travel bans will first halt the outbreak and then eradicate the microbe, and the world will never see 2019-nCoV again, as epidemiologist Dr. Mike Ryan, head of health emergencies at the World Health Organization, told STAT on Saturday. That's what happened with SARS in 2003. Many experts, however, view that happy outcome as increasingly unlikely. "Independent self-sustaining outbreaks [of 2019-nCoV] in major cities globally could become inevitable because of substantial exportation of pre-symptomatic cases," scientists at the University of Hong Kong concluded in a paper published in The Lancet last week. Researchers are therefore asking what seems like a defeatist question but whose answer has huge implications for public policy: What will a world with endemic 2019-nCoV -- circulating permanently in the human population -- be like?

A group of online archivists have created an open-access directory of over 5,000 scientific studies about coronaviruses that anyone can browse and download without encountering a paywall . From a report: The directory is hosted on The-Eye, a massive online archiving project run by a Reddit user named "-Archivist." Last week, the World Health Organization (WHO) declared a global health emergency amid the spread of the novel coronavirus beyond China, where it originated, into roughly two dozen countries so far. The organizers of the archive see their project as a resource for scientists and non-scientists alike to study the virus. "These articles were always written to be shared with as many people as possible," Reddit user "shrine," an organizer of the archive, said in a call. "From every angle that you look at it, [paywalled research] is an immoral situation, and it's an ongoing tragedy."

In 2015, Liberian public health officials co-authored a New York Times op-ed that lamented the amount of critical Ebola research that was unknown or inaccessible to scientists and health workers at the center of the 2014 epidemic. "Even today, downloading one of the papers would cost a physician here $45, about half a week's salary," the authors wrote. Shrine, who is in his late 20s, said he was inspired to assemble the archive when, last week, he clicked on a new research article about the coronavirus and encountered a $39.95 paywall. He and a few friends started to brainstorm solutions around paywalls like the one he had run into. They came up with the idea of searching for coronavirus-related papers on Sci-Hub, a free scientific research repository sometimes called "the Pirate Bay of science." Sci-Hub's site says it provides free access to over 78 million research articles by downloading HTML and PDF pages off the web, in some cases bypassing paywalls. Because of this, major scientific publishing companies -- most prominently Elsevier -- have repeatedly sued Sci-Hub for copyright infringement. Similarly, by disseminating PDFs from Sci-Hub, the coronavirus archive is in questionable legal territory.

Thanks to the coronavirus outbreak, working from home is no longer a privilege, it's a necessity. From a report: While factories, shops, hotels and restaurants are warning about plunging foot traffic that is transforming city centers into ghost towns, behind the closed doors of apartments and suburban homes, thousands of businesses are trying to figure out how to stay operational in a virtual world. "It's a good opportunity for us to test working from home at scale," said Alvin Foo, managing director of Reprise Digital, a Shanghai ad agency with 400 people that's part of Interpublic Group. "Obviously, not easy for a creative ad agency that brainstorms a lot in person." It's going to mean a lot of video chats and phone calls, he said. The cohorts working from home are about to grow into armies. At the moment, most people in China are still on vacation for the Lunar New Year. But as Chinese companies begin to restart operations, it's likely to usher in the world's largest work-from-home experiment.

That means a lot more people trying to organize client meetings and group discussions via videochat apps, or discussing plans on productivity software platforms like WeChat Work or Bytedance's Slack-like Lark. The vanguards for the new model of scattered employees are the Chinese financial centers of Hong Kong and Shanghai, cities with central business districts that rely on hundreds of thousands of office workers in finance, logistics, insurance, law and other white-collar jobs. One Hong Kong banker said he's going to extend an overseas vacation, as he can work from anywhere with a laptop and a phone. Others say they are using the time typically spent wining and dining clients to clear their backlog of travel expenses. One said he's shifted focus to deals in Southeast Asia.

"It's been almost a year since Instagram pledged to reduce the spread of vaccine-related misinformation on its platform. But today, it continues to do the exact opposite," reports the Huffington Post: When HuffPost created a new Instagram account and searched for the term "vaccines" on Saturday, almost all of the top results were anti-vax pages... At the very top was a profile with more than 74,000 followers and posts pushing blatant falsehoods about vaccines and the Wuhan coronavirus. As soon as HuffPost followed that account, Instagram recommended dozens more that, just like it, were promoting dangerous medical misinformation amid a global health emergency.

With its 1 billion users, the role that Facebook-owned Instagram plays in shaping public discourse is not easily understated.

An anonymous reader quotes Reuters: Thai doctors have seen success in treating severe cases of the new coronavirus with combination of medications for flu and HIV, with initial results showing vast improvement 48 hours after applying the treatment, they said on Sunday...

"This is not the cure, but the patientâ(TM)s condition has vastly improved. From testing positive for 10 days under our care, after applying this combination of medicine the test result became negative within 48 hours," Dr. Kriangska Atipornwanich, a lung specialist at Rajavithi, told reporters.

A coronavirus has now infected over 14,380 people worldwide and killed at least 304 people in China, reports the New York Times. But they also note that when the first symptoms appeared in December, Chinese authorities "silenced doctors and others for raising red flags." They played down the dangers to the public, leaving the city's 11 million residents unaware they should protect themselves. They closed a food market where the virus was believed to have started, but didn't broadly curb the wildlife trade.

Their reluctance to go public, in part, played to political motivations as local officials prepared for their annual congresses in January. Even as cases climbed, officials declared repeatedly that there had likely been no more infections.

By not moving aggressively to warn the public and medical professionals, public health experts say, the Chinese government lost one of its best chances to keep the disease from becoming an epidemic. "This was an issue of inaction," said Yanzhong Huang, a senior fellow for global health at the Council on Foreign Relations who studies China. "There was no action in Wuhan from the local health department to alert people to the threat."

The first case, the details of which are limited and the specific date unknown, was in early December. By the time the authorities galvanized into action on Jan. 20, the disease had grown into a formidable threat.

It is now a global health emergency.
The Times also reports on the last day of 2019, the police even announced "that they were investigating eight people for spreading rumors about the outbreak."

And days later Wuhan's mayor spoke to the Communist Party-run legislatures, promising that his city would soon host a World Health Expo.

The Trump administration on Friday declared a public healthy emergency over the coronavirus outbreak and said any foreign national who has traveled within China in the last 14 days will not be allowed to enter the country. The Wall Street Journal reports: The announcement [from U.S. Health and Human Services Secretary Alex Azar] came as stock markets tumbled amid concern about how the impact of the virus could slow global growth. At the same time, Mr. Azar sought to minimize fears about the virus spreading further in the U.S. "I hope that people will see that their government is taking responsible steps to protect them," he said at a White House briefing. "The risk is low... but our job is to keep that risk low."

There are six confirmed cases in the U.S. and 191 people are under investigation, officials said. Meantime, Americans who were evacuated from the epicenter of the China coronavirus outbreak will be quarantined for 14 days at a U.S. military base to prevent any spread of the infectious disease, federal health authorities said Friday. The quarantine -- the first in the U.S. ordered by the federal government in roughly 50 years -- came as the U.K. and Russia each reported their first cases of the dangerous virus, while other countries moved to limit air traffic with China as the number of people infected there approached 10,000. The quarantine applies to 195 U.S. citizens evacuated Wednesday from Wuhan, the Chinese city at the center of the outbreak, and brought to the March Air Reserve Base in Riverside County, Calif., the Centers for Disease Control and Prevention said. The State Department also on Friday advised Americans in China to consider leaving and requested all nonessential U.S. government personnel to postpone travel there.

The State Department's "Do Not Travel" advice placed China on the same list as Afghanistan, Iran, Syria, North Korea and Venezuela. It follows the WHO's designation Thursday of the coronavirus as a global public-health emergency.

Additionally, Delta Air Lines and American Airlines said they will suspend all U.S.-China flights for at least several weeks due to the outbreak. Delta's suspensions will begin Feb. 6 and last through April 30.

Delta Air Lines and American Airlines said on Friday that they will suspend all U.S.-China flights for at least several weeks due to the coronavirus outbreak. Delta on Friday said its China service suspension will begin Feb. 6 and last through April 30, but it will continue to operate the service until then to "ensure customers looking to exit China have options to do so." From a report: Dozens of carriers including United, Cathay Pacific, British Airways and others have slashed or suspended service to China because of the outbreak. Delta was the first in the U.S. to suspend service altogether. Large companies spanning industries from technology to packaged food have suspended business trips to the country because of coronavirus, driving down demand for flights to China. Time has a more comprehensive list.

The World Health Organization on Thursday declared an international public health emergency over the deadly new coronavirus that has hit China hard. From a report: The announcement comes as nearly a hundred cases have been spotted in countries outside of China, including the first case of human-to-human transmission in the U.S., also reported on Thursday. The WHO's decision on the outbreak of virus, known as 2019-nCoV, was made following a lengthy discussion by experts assembled by the agency. Last week, the same committee deliberated for two days about whether to call for a public health emergency of international concern (PHEIC), as it's officially known, but declined to do so. While China has reported a large surge of cases since then -- over 7,700 cases and 170 deaths as of early January 30 -- the move to now call for an international emergency was motivated by the worsening situation outside of China, according to WHO chief Tedros Adhanom Ghebreyesus. As of Thursday, there have been 98 cases reported outside of mainland China in at least 18 countries, but no deaths outside of China. "The main reason for this declaration is not because of what is happening in China, but because of what is happening in other countries," Tedros said at the press conference announcing the PHEIC today. "We don't know what sort of damage this virus could do if it were to spread in a country with a weaker health system. We must act now to help countries prepare for that possibility."

An anonymous reader quotes a report from ScienceAlert: On Monday, researchers from Japan's Osaka University announced the successful completion of a first-of-its-kind heart transplant. Rather than replacing their patient's entire heart with a new organ, these researchers placed degradable sheets containing heart muscle cells onto the heart's damaged areas -- and if the procedure has the desired effect, it could eventually eliminate the need for some entire heart transplants.

To grow the heart muscle cells, the team started with induced pluripotent stem (iPS) cells. These are stem cells that researchers create by taking an adult's cells -- often from their skin or blood -- and reprogramming them back into their embryonic-like pluripotent state. At that point, researchers can coax the iSP cells into becoming whatever kind of cell they'd like. In the case of this Japanese study, the researchers created heart muscle cells from the iSP cells before placing them on small sheets. The patient, which suffers from ischemic cardiomyopathy, will be monitored for the next year. If all goes well, the researchers hope to conduct the same procedure on nine other people suffering from the same condition within the next three years.

Google is temporarily shutting down all of its China offices due to the coronavirus outbreak, as well as offices in Hong Kong and Taiwan. The Verge reports: Currently, the offices are closed for the extended Lunar New Year holiday, a measure the Chinese government took to help reduce the spread of the virus by encouraging residents to stay inside and avoid travel. A Google spokesperson says the company now plans to keep its offices closed in accordance with the government guidance, and it's also placed temporary business travel restrictions on flying to mainland China and Hong Kong. The company is also advising employees currently in China, and employees who have immediate family members returning from the country, return home as soon as possible and to work from home for at least 14 days from their departure date. Apple is also taking action to reduce the spread of the virus by temporarily shutting down three stores located China. Two of the stores were in malls in Nanjing and Fuzhou, China, while the other was in Qingdao, China. They are expected to reopen next week.

An anonymous reader quotes a report from CNN: The first person diagnosed with the Wuhan coronavirus in the United States is being treated by a few medical workers and a robot. The robot, equipped with a stethoscope, is helping doctors take the man's vitals and communicate with him through a large screen, said Dr. George Diaz, chief of the infectious disease division at the Providence Regional Medical Center in Everett, Washington. "The nursing staff in the room move the robot around so we can see the patient in the screen, talk to him," Diaz said, adding the use of the robot minimizes exposure of medical staff to the infected man. It's unclear when the patient will be released because the CDC, which is set to provide the discharge details, has recommended additional testing. "They're looking for ongoing presence of the virus," Diaz told CNN on Thursday. "They're looking to see when the patient is no longer contagious."

An anonymous reader shares a report: People are panicking. When a new disease is discovered, it's undeniably hard to identify and inform the public about it quickly. Yet China is making the problem harder to solve, even though it should have learned from the SARS outbreak in 2003, when the government admitted to underreporting cases in the initial stages. Nearly 800 people died in that epidemic, which saw desperate people emptying shops for Chinese herbal medicines and vinegar that would turn out to be ineffective. That frenzy was driven by the lack of accurate information and rumors because of a vacuum in top-down communication. The idea of wei wen, or maintaining stability in China's political system made "conceal as many as possible and keep it at the local level" a natural immediate response to a crisis like this.

That approach to information might work on other kinds of issues, but not when it comes to a potential epidemic. Trying to control information in that case becomes a kind of shackle in the face of something that can progress and change swiftly beyond one's control. Of course, there is one thing that's different than 17 years ago: WeChat. A tool connecting more than a billion users in China should be one the government can use to help keep the public up-to-date, and to debunk false information. Yet it too has become a hotbed for both rumors and information suppression amid China's broader regime of online censorship honed over the past decade. Already, a focus of social media discussion about the current virus crisis has been on how hard it's been to get correct information, and whether officials were slow to respond in the early stages, at least in Wuhan. While some international public health experts have commended China's information sharing as superior to 2003 in the face of a quickly evolving situation, others have expressed doubt that the country is being as transparent as it should be.

Security researchers from CyberMDX, a cyber-security company specialized in healthcare security, have disclosed today technical details about six vulnerabilities they are collectively referring to as MDhex. From a report: The vulnerabilities impact seven GE Healthcare devices meant for patient vital signs monitoring. These are devices installed near patient beds, meant to collect data from sick patients, and send it back to a telemetry server, monitored by clinical staff.

Huawei has postponed its upcoming HDC.Cloud developer conference as Chinese authorities try to control the spread of the deadly coronavirus detected in the southeastern city of Wuhan. From a report: The controversial company's event was going to take place in Shenzhen -- which lies more than 700 miles south of Wuhan -- Feb. 11-12, but it's been rescheduled to March 27-28. "Based on the prevention and control of the pneumonia epidemic situation of the new coronavirus infection, we attach great importance to the health and safety of all the participants," Huawei said in its announcement. It also asked staff to avoid traveling to Wuhan and limit contact with animals, Reuters reported, and said it set up an outbreak prevention and control team in the city.

An anonymous reader quotes a report from the BBC: Scientists say they may have discovered why stress makes hair turn white, and a potential way of stopping it happening without reaching for the dye. Researchers behind the study, published in Nature, from the Universities of Sao Paulo and Harvard, believed the effects were linked to melanocyte stem cells, which produce melanin and are responsible for hair and skin color. And while carrying out in experiments on mice, they stumbled across evidence this was the case.

Pain in mice triggered the release of adrenaline and cortisol, making their hearts beat faster and blood pressure rise, affecting the nervous system and causing acute stress. This process then sped up the depletion of stem cells that produced melanin in hair follicles. In another experiment, the researchers found they could block the changes by giving the mice an anti-hypertensive, which treats high blood pressure. And by comparing the genes of mice in pain with other mice, they could identify the protein involved in causing damage to stem cells from stress. When this protein -- cyclin-dependent kinase (CDK) -- was suppressed, the treatment also prevented a change in the color of their fur. This leaves the door open for scientists to help delay the onset of grey hair by targeting CDK with a drug.

The first case of an infection with a new coronavirus has been discovered in the United States. NPR reports: A man from Washington state returned home after a trip to Wuhan, China, on Jan. 15, sought medical attention on Jan. 19 and now is in isolation at Providence Regional Medical Center in Everett, Wash. State health officials say his condition is quite good and even referred to him as "healthy." But testing from the Centers for Disease Control and Prevention on the 20th confirm that he is infected with the Wuhan coronavirus. The man arrived back in the U.S. prior to the implementation of screening at three domestic airports on Friday. As of yesterday, over 200 cases of the virus have been reported in China.

An anonymous reader quotes a report from the BBC: The Cardiff University team discovered a method of killing prostate, breast, lung and other cancers in lab tests. The findings, published in Nature Immunology, have not been tested in patients, but the researchers say they have "enormous potential." Our immune system is our body's natural defense against infection, but it also attacks cancerous cells. The scientists were looking for "unconventional" and previously undiscovered ways the immune system naturally attacks tumors. What they found was a T-cell inside people's blood. This is an immune cell that can scan the body to assess whether there is a threat that needs to be eliminated. The difference is this one could attack a wide range of cancers.

T-cells have "receptors" on their surface that allow them to "see" at a chemical level. The Cardiff team discovered a T-cell and its receptor that could find and kill a wide range of cancerous cells in the lab including lung, skin, blood, colon, breast, bone, prostate, ovarian, kidney and cervical cancer cells. Crucially, it left normal tissues untouched. Exactly how it does this is still being explored. This particular T-cell receptor interacts with a molecule called MR1, which is on the surface of every cell in the human body. It is thought MR1 is flagging the distorted metabolism going on inside a cancerous cell to the immune system. Treatment would include extracting T-cells from a blood sample of a cancer patient and then genetically modifying them so they were reprogrammed to make the cancer-finding receptor. The upgraded cells would be grown in vast quantities in the lab and then put back into the patient.

Two months ago the Washington Post reported that Google "has partnered with health-care provider Ascension to collect and store personal data for millions of patients, including full names, dates of birth and clinical histories, in order to make smarter recommendations to physicians."

Now CNBC reports that the medical record vendor Epic Systems "has been phoning customers to tell them it will not pursue further integration with Google Cloud. The company is instead focusing on Amazon AWS and Microsoft Azure, citing insufficient interest from customers in Google.

"The move comes as Google is facing criticism from privacy advocates about its work with Ascension, one of the largest U.S. health systems," CNBC adds. But could this start influencing which cloud provider hospitals choose for their records?

"We've historically seen hospital systems make these decisions independently of their medical record provider," said Aneesh Chopra, the president of health-technology company CareJourney and the former chief technology officer of the United States. "It will be interesting to see if Epic's thumb on the scale moves cloud market share...."

Epic isn't alone in its move.

The Wall Street Journal recently reported that Cerner decided against pursuing a data-storage relationship with Google despite being offered tens of millions of dollars in incentives. The company was on the hunt for a cloud vendor to help it store 250 million patient medical records. In the end, Cerner went with Amazon.
In 2017 CNBC reported Cerner's collaboration with Amazon would initially focus on a "popular health product...which enables hospitals to gather and analyze huge volumes of clinical data to improve patients' health outcomes and lower treatment costs."

schwit1 shares a report from The Wall Street Journal: Nearly 150 years ago, [German physician Carl Reinhold August Wunderlich] analyzed a million temperatures from 25,000 patients and concluded that normal human-body temperature is 98.6 degrees Fahrenheit. In a new study, researchers from Stanford University argue that Wunderlich's number was correct at the time but is no longer accurate because the human body has changed. Today, they say, the average normal human-body temperature is closer to 97.5 degrees Fahrenheit (Warning: source paywalled; alternative source).

To test their hypothesis that today's normal body temperature is lower than in the past, Dr. Parsonnet and her research partners analyzed 677,423 temperatures collected from 189,338 individuals over a span of 157 years. The readings were recorded in the pension records of Civil War veterans from the start of the war through 1940; in the National Health and Nutrition Examination Survey I conducted by the U.S. Centers for Disease Control and Prevention from 1971 through 1974; and in the Stanford Translational Research Integrated Database Environment from 2007 through 2017. Overall, temperatures of the Civil War veterans were higher than measurements taken in the 1970s, and, in turn, those measurements were higher than those collected in the 2000s. The study has been published in the journal eLife.