Friday the New York Times (following up on reports from the Wall Street Journal) wrote that China had "refused to hand over" important raw data to a 14-member World Health Organization team investigating the origins of the coronavirus, reporting that "their Chinese counterparts were frustrated by the team's persistent questioning and demands for data."

But Saturday two of those 14 team members disputed that characterization, posting on Twitter that "This was NOT my experience" — even though the Times had quoted both of them to support its article.

First Peter Daszak, president of the U.S. national science academy's microbial threats forum, weighed in. "As lead of animal/environment working group I found trust and openness with my China counterparts. We DID get access to critical new data throughout. We DID increase our understanding of likely spillover pathways. New data included env. & animal carcass testing, names of suppliers to Huanan Market, analyses of excess mortality in Hubei, range of covid-like symptoms for months prior, sequence data linked to early cases & site visits w/ unvetted live Q&A etc. All in report coming soon!"

Then Thea Kølsen Fischer, a Danish epidemiologist on the team, tweeted that the Times hadn't accurately described her experience either. "We DID build up a good relationship in the Chinese/Int Epi-team! Allowing for heated arguments reflects a deep level of engagement in the room. Our quotes are intendedly twisted casting shadows over important scientific work."

Daszak reappeared to respond to her tweet, writing "Hear! Hear! It's disappointing to spend time with journalists explaining key findings of our exhausting month-long work in China, to see our colleagues selectively misquoted to fit a narrative that was prescribed before the work began. Shame on you @nytimes!"

Ironically, the next day the Times published a longer interview they'd done with Daszak, which acknowledges that Daszak "said that the visit had provided some new clues..."

The Times had even specifically asked him if China's attitude made their work difficult, to which Daszak explicitly had answered: no.

Long-time Slashdot reader theodp writes: As the first COVID-19 vaccines arrived at Penn Medicine last year, Penn Today reported with great pride, "It was mRNA research conducted at Penn—by Drew Weissman, a professor of Infectious Diseases, and Katalin Karikó, an adjunct associate professor—that helped pave the way for the development of the Pfizer-BioNTech and Moderna COVID vaccines." While Weissman and Karikó are coronavirus vaccine heroes these days, Dr. David Scales — who studied under Weissman and Karikó 20 years ago as they worked on mRNA vaccines aimed to fight HIV — recalls How Our Brutal Science System Almost Cost Us A Pioneer Of mRNA Vaccines.

"When I got my own [COVID vaccine] shot," Scales writes, "I felt an added emotion: awe. You see, I witnessed some of the early scientific heartbreaks that came before the historic vaccine victories. And I found myself simply awestruck by the scientists I knew who persevered in spite of our system of scientific research. [...] While Weissman was an expert at designing experiments, I remember him most for his generosity. He made sure all contributors in the lab shared the credit, from the lab tech and lowly undergrad all the way to fellow researcher Karikó. Still, Karikó was struggling. Her science was fantastic, but she was less adept at the competitive game of science. She tried again and again to win grants, and each time, her applications were rejected. Eventually, in the mid-1990s, she suffered the academic indignity of demotion, meaning she was taken off the academic ladder that leads to becoming a professor. [...] But [Karikó] stuck to her passions. She was too committed to the promise of mRNA to switch to other, perhaps more easily fundable projects. Eventually, the university stopped supporting her."

"Academic science failed Karikó. But when she contacted me in 2015, I saw she had moved to the private sector, a common path for researchers when a university stops offering support. I was glad to see she had landed on her feet. And now, I watch in awe, like the rest of the world, as the technology she helped developed leads to one of the most spectacular victories in the history of science — a vaccine for a deadly pandemic developed in less than one year. So, my vaccination day was an emotional one. As the lipid-encapsulated mRNA molecules went into my arm, I reminisced about Kati and Drew, and the lab circa 2000. And I thought: You were right, Kati. You were right."

Federal authorities are investigating a massive counterfeit N95 mask operation in which fake 3M masks were sold in at least five states to hospitals, medical facilities and government agencies. From a report: The foreign-made knockoffs are becoming increasingly difficult to spot and could put health care workers at grave risk for the coronavirus. These masks are giving first responders "a false sense of security," said Steve Francis, assistant director for global trade investigations with the Homeland Security Department's principal investigative arm. He added, "We've seen a lot of fraud and other illegal activity." Nearly a year into the pandemic, fraud remains a major problem as scammers seek to exploit hospitals and desperate and weary Americans. Federal investigators say they have seen an increase in phony websites purporting to sell vaccines as well as fake medicine produced overseas and scams involving personal protective equipment. The schemes deliver phony products, unlike fraud earlier in the pandemic that focused more on fleecing customers.

31.9 million Americans have already received one or both doses of a Covid-19 vaccine — including more than 9.3 million people who have been fully vaccinated.

And now USA Today reports: Pfizer expects to nearly cut in half the amount of time it takes to produce a batch of COVID-19 vaccine from 110 days to an average of 60 as it makes the process more efficient and production is built out, the company told USA TODAY. As the nation revs up its vaccination programs, the increase could help relieve bottlenecks caused by vaccine shortages.

"We call this 'Project Light Speed,' and it's called that for a reason," said Chaz Calitri, Pfizer's vice president for operations for sterile injectables, who runs the company's plant in Kalamazoo, Michigan. "Just in the last month we've doubled output."

The increased speed and capacity is not unexpected, said Robert Van Exan, president of Immunization Policy and Knowledge Translation, a vaccine production consulting firm. "Nobody's ever produced mRNA vaccines at this scale, so you can bet your bottom dollar the manufacturers are learning as they go. I bet you every day they run into some vaccine challenge and every day they solve it, and that goes into their playbook," he said...

As soon as vials of vaccine began coming off the production line, engineers started analyzing how production could work faster and better. "We made a lot of really slick enhancements," he said. Production is getting faster. For example, making the DNA that starts the vaccine process first took 16 days; soon it will take nine or 10. Though quality control and testing has accelerated, company officials say FDA regulations and best manufacturing practices are still being met. Along with improving speed, Pfizer also is increasing output by adding manufacturing lines in all three plants.

As the vaccine effort continues, more efficiencies are expected.
Across America a bout 20.6 million doses of the Pfizer vaccine have already been administered.

"Catching the coronavirus from surfaces is rare. The World Health Organization and national public-health agencies need to clarify their advice," urges an editorial in Nature (shared by long-time Slashdot reader AmiMoJo): A year into the pandemic, the evidence is now clear. The coronavirus SARS-CoV-2 is transmitted predominantly through the air — by people talking and breathing out large droplets and small particles called aerosols.

Catching the virus from surfaces — although plausible — seems to be rare. Despite this, some public-health agencies still emphasize that surfaces pose a threat and should be disinfected frequently. The result is a confusing public message when clear guidance is needed on how to prioritize efforts to prevent the virus spreading... People and organizations continue to prioritize costly disinfection efforts, when they could be putting more resources into emphasizing the importance of masks, and investigating measures to improve ventilation. The latter will be more complex but could make more of a difference.

Now that it is agreed that the virus transmits through the air, in both large and small droplets, efforts to prevent spread should focus on improving ventilation or installing rigorously tested air purifiers. People must also be reminded to wear masks and maintain a safe distance. At the same time, agencies such as the WHO and the CDC need to update their guidance on the basis of current knowledge. Research on the virus and on COVID-19 moves quickly, so public-health agencies have a responsibility to present clear, up-to-date information that provides what people need to keep themselves and others safe.

Alaska, the state with the largest land mass in the nation, is leading the country in a critical coronavirus measure: per capita vaccinations per capita vaccinations. From a report: About 13 percent of the people who live in Alaska have already gotten a shot. That's higher than states such as West Virginia, which has received a lot of attention for a successful vaccine rollout and has inoculated 11 percent of its people. But the challenge for Alaska has been how to get vaccines to people across difficult, frigid terrain -- often in remote slivers of the state? "Boats, ferries, planes, snowmobiles -- Alaskans will find a way to get it there," said the state's chief medical officer, Anne Zink, 43. Alaskans are being vaccinated on fishing boats, inside 10-seater planes and on frozen landing strips. Doctors and nurses are taking white-knuckle trips to towns and villages across the state to ensure residents are protected from the coronavirus. Contributing to Alaska's quick speed in getting the vaccine to its residents is a federal partnership that allows the state, which has more than 200 indigenous tribes, to receive additional vaccines to distribute through the Indian Health Service.

23andMe is becoming a publicly-traded company through a merger with Virgin's VG Acquisition. Engadget reports: The deal values 23andMe at about $3.5 billion and should give the company the finances it wants to boost its personal healthcare and therapeutics plans. It should have over $900 million in cash, for instance. The merger is expected to close in the second quarter of 2021 and will have private $25 million investments from both 23andMe chief Anne Wojcicki and Virgin's Sir Richard Branson.

While 23andMe didn't say much about how its strategy might change by going public, it was keen to promote its contributions to genetic research and its involvement in therapeutic programs for conditions like cardiovascular disease and respiratory issues. As Sir Branson suggested, the public offering could help 23andMe "revolutionize" personalized medicine.

According to a new study, the Apple Watch can be used to monitor symptoms of Parkinson's disease. STAT reports: Researchers at Apple, working with specialists who treat Parkinson's, designed a system that uses the Apple Watch to detect the motor symptoms that are a hallmark of the neurological disease. By monitoring resting tremors and other involuntary movements, the researchers were able to identify the characteristic "on" and "off" patterns of medication's effects. Their findings were published Wednesday in Science Translational Medicine.

The new system, called the Motor Fluctuations Monitor for Parkinson's disease (MM4PD), uses the Apple Watch's accelerometer and gyroscope data to detect the presence of resting tremor or dyskinesia. Resting tremors, which can affect the hands, legs, and other parts of the body, are a common symptom of Parkinson's. Dyskinesia, another type of involuntary movement, is a frequent side effect of medication used to treat the disease. The algorithms underlying the model were developed using data from a pilot study with 118 people in which researchers matched subject's smartwatch data to a scoring system called MDS-UPDRS Part III, the gold standard by which motor symptoms of Parkinson's are measured.

The authors say that the measurements helped spot symptoms missed in regular care and identified changes after subjects underwent surgery for deep brain stimulation. The paper also suggests the tool helped pinpoint people who slipped on medication adherence, as well as cases in which a person might benefit from a modified medication regimen.

Israel's vaccination drive has reduced confirmed Covid-19 cases among older Israelis, Prime Minister Benjamin Netanyahu said on Thursday. From a report: Netanyahu cited a 45% drop in confirmed cases and a 26% decline in hospitalizations of seriously ill patients among people age 60 and older in the past 16 days. Israel's vaccination drive, which began in late December, started with this age group, and more than 80% have had at least one dose of the Pfizer-BioNTech vaccine. Further reading: Israel Is Now The First Country Where Vaccinations Are Starting To Curb The Pandemic.

omfglearntoplay shares a report from ScienceAlert: There's already a long list of reasons to like trees, we know. Warding off depression could be the latest entry on that list, based on a study of 9,751 residents in Leipzig, Germany. For a more consistent measure, researchers used antidepressant prescriptions rather than self-reporting to gauge the mental health of communities, and then cross-referenced these statistics with the numbers of street trees in each area. They reported that more local foliage within 100 meters (328 feet) of the home was associated with a reduced likelihood of being prescribed antidepressants -- findings that could be very useful indeed for city planners, health professionals, and governments.

The reduction in antidepressant use linked to street trees was particularly prominent in socioeconomically disadvantaged groups. While it's important not to take such findings too far, the results do hint that urban trees could act as a simple and affordable way of boosting mental health and assist in closing health inequality gaps across society. The research has been published in Scientific Reports.

A new research study at the University of Missouri is using CRISPR gene-editing technology to produce mosquitoes that are unable to replicate Zika virus and therefore cannot infect a human through biting. Slashdot reader wooloohoo shared an announcement from Cornell's Alliance for Science: Alexander Franz, an associate professor in the MU College of Veterinary Medicine, collaborated with researchers at Colorado State University... Their work was recently published in the journal Viruses. Franz added that the genetic modification is inheritable, so future generations of the altered mosquitoes would be resistant to Zika virus as well... "[W]e are simply trying to expand the toolbox and provide a solution by genetically modifying the mosquitoes to become Zika-resistant while keeping them alive at the same time."

Franz' research is designed to help prevent another outbreak of Zika virus disease from occurring while also addressing concerns that have some have raised about reducing populations of mosquitoes, which are a food source for some animals...

The study was funded by the National Institutes of Health.

An anonymous reader quotes a report from NPR: New coronavirus variants seem to be cropping up everywhere. There's one from the U.K., which is more contagious and already circulating in the United States. There's one from South Africa, which is forcing Moderna and Pfizer to reformulate their COVID-19 vaccines and create "booster" shots, just to make sure the vaccines maintain their efficacies. But for some scientists, the most worrying variant might be the newest one. A variant called P.1, which emerged in early December in Manaus, Brazil, and by mid-January had already caused a massive resurgence in cases across the city of 2 million people. [...] The concern with P.1 is twofold: scientists don't understand why the variant has spread so explosively in Brazil, and the variant carries a particularly dangerous set of mutations.

While the variant from the U.K. took about three months to dominate the outbreak in England, P.1 took only about a month to dominate the outbreak in Manaus. In addition, Manaus had already been hit extremely hard by the virus back in April. One study estimated that the population should have reached herd immunity and the virus shouldn't be able to spread easily in the community. So why would the city see an even bigger surge 10 months later? Could P.1 be evading the antibodies made against the previous version of the virus, making reinfections easier? Could it just be significantly more contagious? Could both be true? "While we don't *know* exactly why this variant has been so apparently successful in Brazil, none of the explanations on the table are good," epidemiologist Bill Hanage, at Harvard University, wrote on Twitter.

Reinfections are a serious concern for several reasons. First off, like the variant from South Africa, P.1 carries a cluster of mutations along the surface of the virus where antibodies -- especially the potent antibodies -- like to bind. "They are kind of the major targets of the immune system," says virologist Penny Moore at the National Institute for Communicable Diseases in South Africa and the University of KwaZulu-Natal. "So when we see a whole lot of mutations in [those surfaces], it raises the possibility that the mutations might be conferring immune escape." That is, the mutations are helping the virus evade antibodies or escape recognition by them. In essence, the mutations are providing the virus with a type of invisibility cloak. And thus, now we have a game of "cat and mouse," says virologist Ravi Gupta, between the virus and the vaccine. The virus finds ways around the vaccine (and our immune system), says Gupta, and so the manufacturers have to reformulate the vaccines (or else we run the risk of getting infected twice).

Joe2020 shares a report: China has begun using anal swabs to test those it considers to be at high risk of contracting Covid-19, state TV has reported. Officials took anal swabs from residents of neighbourhoods with confirmed Covid-19 cases in Beijing last week, according to the state broadcaster CCTV, while those in designated quarantine facilities have also had the tests. Small, localised outbreaks in recent weeks have resulted in multiple cities in northern China being sealed off from the rest of the country and prompted mass testing campaigns, which had mostly been conducted using throat and nose swabs. The anal swabs method "can increase the detection rate of infected people" as traces of the virus linger longer in the anus than in the respiratory tract, Li Tongzeng, a senior doctor from Beijing's Youan hospital, told CCTV. CCTV said on Sunday anal swabs would not be used as widely as other methods, as the technique was "not convenient."

New submitter wooloohoo shares a report from Ars Technica: The rollout of the COVID-19 vaccine means a ton of people are soon going to be looking for vaccination sites. As usual, Google wants to be at the center of getting people where they're going, and in a new blog post Google says it will start loading Search and Maps with information on vaccination sites. "In the coming weeks," the company writes, "COVID-19 vaccination locations will be available in Google Search and Maps, starting with Arizona, Louisiana, Mississippi and Texas, with more states and countries to come."

Soon you'll be able to search "COVID vaccine" and get location results showing access requirements, appointment information, and if a site has a drive-through. Google says it is partnering with the Boston Children's Hospital's VaccineFinder.org, government agencies, and retail pharmacies for the data. Elsewhere in the Google Empire, the company says it will open up various Google facilities as vaccine sites. "Google also says it plans on launching a 'Get the Facts' campaign across its services," the report adds. "The post says the initiative will run across Google and YouTube to 'get authoritative information out to the public about vaccines.'"

Moderna's Covid vaccine appears to work against new, more infectious variants of the pandemic virus found in the UK and South Africa, say scientists from the US pharmaceutical company. The BBC reports: Early laboratory tests suggest antibodies triggered by the vaccine can recognize and fight the new variants. More studies are needed to confirm this is true for people who have been vaccinated. Current vaccines were designed around earlier variants, but scientists believe they should still work against the new ones, although perhaps not quite as well. There are already some early results that suggest the Pfizer vaccine protects against the new UK variant.

For the Moderna study, researchers looked at blood samples taken from eight people who had received the recommended two doses of the Moderna vaccine. The findings are yet to be peer reviewed, but suggest immunity from the vaccine recognizes the new variants. Neutralizing antibodies, made by the body's immune system, stop the virus from entering cells. Blood samples exposed to the new variants appeared to have sufficient antibodies to achieve this neutralizing effect, although it was not as strong for the South Africa variant as for the UK one. Moderna says this could mean that protection against the South Africa variant might disappear more quickly. Moderna says it's investigating whether a redesigned vaccine would be more effective against the new variants. It's also testing whether giving a third booster shot might be beneficial.

Google CEO Sundar Pichai on Monday said the company will make its office facilities available for COVID-19 vaccination clinics, as tech giants aim to speed up distribution efforts in the US. From a report: The company said it's partnering with the health care provider One Medical for the clinics, which will be opened "as needed" at Google buildings, parking lots and open spaces. For now, Google is targeting its campuses in the San Francisco Bay Area, where the company is headquartered; Los Angeles; New York City; and Kirkland, Washington, outside of Seattle. [...] The company also said it will use artificial intelligence from its Google Cloud division to help health care providers and pharmacies with the logistics of vaccine distribution. That includes detecting changes in the temperature of vaccine doses, which must be stored in cool conditions. Google also said it's committing more than $150 million in free ads and other investments to public health agencies and nonprofits promoting vaccine education.

David Leonhardt won a Pulitzer Prize for commentary in 2011. This week in a New York Times newsletter, he argues that early in the pandemic experts around the world mistakenly discouraged mask use because of "a concern that people would rush to buy high-grade medical masks, leaving too few for doctors and nurses. The experts were also [at the time] unsure how much ordinary masks would help."

But are they now spreading a similarly misguided pessimism about vaccines? Right now, public discussion of the vaccines is full of warnings about their limitations: They're not 100 percent effective. Even vaccinated people may be able to spread the virus. And people shouldn't change their behavior once they get their shots...

"It's going to save your life — that's where the emphasis has to be right now," Dr. Peter Hotez of the Baylor College of Medicine said. The Moderna and Pfizer vaccines are "essentially 100 percent effective against serious disease," Dr. Paul Offit, the director of the Vaccine Education Center at Children's Hospital of Philadelphia, said. "It's ridiculously encouraging."

Here's my best attempt at summarizing what we know:

- The Moderna and Pfizer vaccines — the only two approved in the U.S. — are among the best vaccines ever created, with effectiveness rates of about 95 percent after two doses. That's on par with the vaccines for chickenpox and measles. And a vaccine doesn't even need to be so effective to reduce cases sharply and crush a pandemic.

- If anything, the 95 percent number understates the effectiveness, because it counts anyone who came down with a mild case of Covid-19 as a failure. But turning Covid into a typical flu — as the vaccines evidently did for most of the remaining 5 percent — is actually a success. Of the 32,000 people who received the Moderna or Pfizer vaccine in a research trial, do you want to guess how many contracted a severe Covid case? One.

Although no rigorous study has yet analyzed whether vaccinated people can spread the virus, it would be surprising if they did.
The article suggests less-positive messages are being conveyed in part because "As academic researchers, they are instinctively cautious, prone to emphasizing any uncertainty."

But the article ultimately concludes that in fact, "the evidence so far suggests that the vaccines are akin to a cure."

Darrell Etherington reports via TechCrunch: Web infrastructure company Cloudflare is releasing a new tool today that aims to provide a way for health agencies and organizations globally tasked with rolling out COVID-19 vaccines to maintain a fair, equitable and transparent digital queue -- completely free of charge. The company's Project Fair Shot initiative will make its new Cloudflare Waiting Room offering free to any organization that qualifies, essentially providing a way for future vaccine recipients to register and gain access to a clear and constantly-updated view of where they are in line to receive the preventative treatment.

On the technical side, Cloudflare Waiting Room is simple to implement, according to the company, and can be added to any registration website built on the company's existing content delivery network without any engineering or coding knowledge required. Visitors to the site can register and will receive a confirmation that they're in line, and then will receive a follow-up directing them to a sign-up page for the organization administering their vaccine when it's their turn. Further configuration options allow Waiting Room operators to offer wait time estimates to registrants, as well as provide additional alerts when their turn is nearing (though that functionality is coming in a future update).

Waiting Room was already on Cloudflare's project roadmap, and was actually intended for other high-demand, limited supply allocation items: Think must-have concert tickets, or the latest hot sneaker release. But the Fair Shot program will provide it totally free to those organizations that need it, whereas that would've been a commercial product. Interested parties can sign up at Cloudflare's registration page to get on the waitlist for availability.

An anonymous reader Phys.Org: The Korea Institute of Science and Technology (KIST) announced that the collaborative research team led by Dr. Kwan Hyi Lee from the Biomaterials Research Center and Professor In Gab Jeong from Asan Medical Center developed a technique for diagnosing prostate cancer from urine within only 20 minutes with almost 100% accuracy. The research team developed this technique by introducing a smart AI analysis method to an electrical-signal-based ultrasensitive biosensor. As a noninvasive method, a diagnostic test using urine is convenient for patients and does not need invasive biopsy, thereby diagnosing cancer without side effects. However, as the concentration of cancer factors is low in urine, urine-based biosensors are only used for classifying risk groups rather than for precise diagnosis thus far.

Dr. Lee's team at the KIST has been working toward developing a technique for diagnosing disease from urine with an electrical-signal-based ultrasensitive biosensor. An approach using a single cancer factor associated with a cancer diagnosis was limited in increasing the diagnostic accuracy to over 90%. However, to overcome this limitation, the team simultaneously used different kinds of cancer factors instead of using only one to enhance the diagnostic accuracy innovatively.

The team developed an ultrasensitive semiconductor sensor system capable of simultaneously measuring trace amounts of four selected cancer factors in urine for diagnosing prostate cancer. They trained AI by using the correlation between the four cancer factors, which were obtained from the developed sensor. The trained AI algorithm was then used to identify those with prostate cancer by analyzing complex patterns of the detected signals. The diagnosis of prostate cancer by utilizing the AI analysis successfully detected 76 urinary samples with almost 100 percent accuracy. The results of the study have been published in the journal ACS Nano.

According to new research from Leicester University and the Office for National Statistics (NS), almost a third of recovered COVID-19 patients will end up back in the hospital within five months and one in eight will die. Yahoo News reports via The Telegraph: Out of 47,780 people who were discharged from hospital in the first wave, 29.4 per cent were readmitted to hospital within 140 days, and 12.3 per cent of the total died. The current cut-off point for recording Covid deaths is 28 days after a positive test, so it may mean thousands more people should be included in the coronavirus death statistics. Researchers have called for urgent monitoring of people who have been discharged from hospital.

Study author Kamlesh Khunti, professor of primary care diabetes and vascular medicine at Leicester University, said: "This is the largest study of people discharged from hospital after being admitted with Covid. People seem to be going home, getting long-term effects, coming back in and dying. We see nearly 30 per cent have been readmitted, and that's a lot of people. The numbers are so large. The message here is we really need to prepare for long Covid. It's a mammoth task to follow up with these patients and the NHS is really pushed at the moment, but some sort of monitoring needs to be arranged."

The study found that Covid survivors were nearly three and a half times more likely to be readmitted to hospital, and die, in the 140 days timeframe than other hospital outpatients. Prof Khunti said the team had been surprised to find that many people were going back in with a new diagnosis, and many had developed heart, kidney and liver problems, as well as diabetes. "We don't know if it's because Covid destroyed the beta cells which make insulin and you get Type 1 diabetes, or whether it causes insulin resistance, and you develop Type 2, but we are seeing these surprising new diagnoses of diabetes,â he added. "We've seen studies where survivors have had MRS scans and they've cardiac problems and liver problems. These people urgently require follow up and the need to be on things like aspirin and statins."