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Biotech Medicine

Researchers Build Tiny Wireless, Injectable Chips, Visible Only Under a Microscope (columbia.edu) 139

Implantable miniaturized medical devices that wirelessly transmit data "are transforming healthcare and improving the quality of life for millions of people," writes Columbia University, noting the devices are "widely used to monitor and map biological signals, to support and enhance physiological functions, and to treat diseases."

Long-time Slashdot reader sandbagger shares the university's newest announcement: These devices could be used to monitor physiological conditions, such as temperature, blood pressure, glucose, and respiration for both diagnostic and therapeutic procedures. To date, conventional implanted electronics have been highly volume-inefficient — they generally require multiple chips, packaging, wires, and external transducers, and batteries are often needed for energy storage... Researchers at Columbia Engineering report that they have built what they say is the world's smallest single-chip system, consuming a total volume of less than 0.1 mm cubed. The system is as small as a dust mite and visible only under a microscope...

"We wanted to see how far we could push the limits on how small a functioning chip we could make," said the study's leader Ken Shepard, Lau Family professor of electrical engineering and professor of biomedical engineering. "This is a new idea of 'chip as system' — this is a chip that alone, with nothing else, is a complete functioning electronic system. This should be revolutionary for developing wireless, miniaturized implantable medical devices that can sense different things, be used in clinical applications, and eventually approved for human use...."

The chip, which is the entire implantable/injectable mote with no additional packaging, was fabricated at the Taiwan Semiconductor Manufacturing Company with additional process modifications performed in the Columbia Nano Initiative cleanroom and the City University of New York Advanced Science Research Center (ASRC) Nanofabrication Facility. Shepard commented, "This is a nice example of 'more than Moore' technology—we introduced new materials onto standard complementary metal-oxide-semiconductor to provide new function. In this case, we added piezoelectric materials directly onto the integrated circuit to transducer acoustic energy to electrical energy...." The team's goal is to develop chips that can be injected into the body with a hypodermic needle and then communicate back out of the body using ultrasound, providing information about something they measure locally.

The current devices measure body temperature, but there are many more possibilities the team is working on.

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Researchers Build Tiny Wireless, Injectable Chips, Visible Only Under a Microscope

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  • by Anonymous Coward on Sunday May 16, 2021 @02:38AM (#61389630)

    You're just now realizing this?

    Just ask Bill Gates. Why do you think Melinda is divorcing him, other than the Jeffrey Epstein thing?

    • by backslashdot ( 95548 ) on Sunday May 16, 2021 @02:41AM (#61389636)

      for fools to be afraid of vaccines.

      • Re: (Score:3, Funny)

        by tigersha ( 151319 )

        Bingo. Bills plan might be to raise human IQ by killing off the antivaxxer idiots.

        Q Why does the 3 year old child of an anti-vaxxer cry?
        A He is having a mid-life crisis.

        • OUCH

          Sad but true.

          Go to a cemetery. Notice all the graves of dead babies from before the 1960s, from before people started vaccinating their kids?

          Notice how few infant deaths since then? That's because vaccinations work.

      • by Z80a ( 971949 )

        The better anti-vax arguments are not "vaccines are bad", but "the government or megacorps may slip something else in the vaccines as well", and it's pretty hard to deflect.

        • The part of, the government is slipping something in which can interface with our neurons and mind control us remotely is pretty much completely fringy with our technology just now. And even the Government or Corporations putting something extra in that can be seen under a microscope would be a non-starter really. Doesn't take anything more than a 7th grader in science class with a microscope to spot that anomaly. Lawsuits anyone?

          • by Z80a ( 971949 )

            That one would be quite a massive stretch. The government would have to be incredibly competent to come up with such technology of mind control etc..

      • Fools? Or cautious? Govt has proven themselves untrustworthy many times, is there a reason we should suddenly trust them?
    • Re: (Score:3, Insightful)

      Before I opened this, I knew this would be the first comment. It's like slashdot has become just as much of a dumpster as reddit and 4chan... I probably haven't been here long enough to see all the changes, though I was a long-time lurker but I am sure some bitter vets can step in and tell us about the good old days of genuine high quality nerd discourse. Even anecdotal tech stories about how a cat took down Amazon when it was still single server (and the general problems of this phenomena can still persist

      • by zenlessyank ( 748553 ) on Sunday May 16, 2021 @03:22AM (#61389690)

        You could have just made your comment and ignored the idjuts, but you fell into the trap of complaining and name calling like the rest.

        The tech for this sounds interesting to say the least, but we all know folks love to take something good and use it for nefarious tasks. Seems like it wont be long before this is used to track people for the government. And before you label me a paranoid, understand that I have no tinfoil on my head but a realistic view of the poisoned world we live in.

        I wonder if folks' immune system will attack/reject this chip or will it be put under the skin where vessels/veins aren't or does it flow through the blood stream passing through the heart.

        So many questions!

        • I agree it is a trap. I just wish there was a better system for weeding it out. I like to browse at Score: 0 because the same people posting such crap can often mod things into oblivion.

          I think the big data problem of tracking everyone is just not fiscally possible. Maybe I underestimate how much funding can be thrown away at data analysis majors, AI, and server farms to really handle the "track everyone" data. The trick is generally always keywords and selective surveillance. I believe a few of the 3 name

        • The only way to power up the chip and read its measurements is by flooding it with ultrasound. So the only way to use this to track someone is by standing right next to the trackee with your ultrasound device. You might as well just follow the trackee, saves you having to implant them with anything.

          So this, like all implanted electronic devices is useless for tracking (as in 'knowing where the trackee is at all times'). Like the chips implanted in pets it could be used for identification, but we already hav

        • by radaos ( 540979 ) on Monday May 17, 2021 @06:34AM (#61392526) Homepage
          Some of the tinfoil hat assertions going around are rooted in technical ignorance.

          How could a 'tracking chip' be powered for years?
          How does it communicate?
          What range does it have?

          This device is the size of a grain of salt.
          For RF, "wavelengths are substantially larger than achievable antenna sizes."
          "The team used ultrasound to both power and communicate with the device wirelessly."
          So it needs ultrasound equipment right beside it to work.

          It is too large for a vaccination size needle (22-25 gauge)
          It is a proof of concept that has not been tested on a live animal, unsurprisingly.
          Embedded foreign bodies present a danger to health, they can migrate from their original site.
          "Such migration can cause injury to critical structures or cause the foreign body to move to a deep layer where it may be difficult to remove."
          https://www.ncbi.nlm.nih.gov/p... [nih.gov]

          Not to mention the difficulty of covering up a vast conspiracy, or how a 'tracking chip' would be completely pointless as most people carry a cellphone anyway.

          In any case, the paranoid will believe what they want to believe.
      • by Nrrqshrr ( 1879148 ) on Sunday May 16, 2021 @03:45AM (#61389732)

        As a third-worlder, I blame it on American users who are, I am afraid, a majority of the website's audience. Ever since Trump got into office, any news related to Trump or his policies (H1B, China, vaccines, big tech censorship...) gets immediately flooded with colourful terms like Trumptard and "right wingers" and "my side is good, your side should get lined against the wall and shot".
        By far the worst offenders were the censorship, deplatforming and the "profiling protestors with AI" ones. This was the last place I expected people to cheer for censorship and invasions of privacy. And yet, this was one of the places I heard the loudest applauds on.

        Merely questioning something like the Corona vaccine isn't allowed unless you are somehow part of the group who refuses EVERY vaccine. You're not sure how healthy it is to have a computer chip in your body? Well, clearly you are a 60 IQ subhuman and should be disregarded from all discussions.

        Social media and the information overload really played a number on people. It made everyone feel like they were part of the underdog resistance.

        • by thegarbz ( 1787294 ) on Sunday May 16, 2021 @05:51AM (#61389876)

          Merely questioning something like the Corona vaccine isn't allowed

          Of course it's allowed. But if you're going to question then you better question with reason and logic, rather than the typical way it has occured here on Slashdot: "Fox and Friends told me so". There have been plenty of questioning posts getting modded up, just don't expect every shitty drivel to be treated equally.

          This was the last place I expected people to cheer for censorship

          No one here has cheered for censorship except those supporting revoking Section 230. The discussions around deplatforming were pointing out the right to free speech is inseparably linked with the right to free association. No own owes you platform, and kicking you out of my house is not censorship.

          Well, clearly you are a 60 IQ subhuman and should be disregarded from all discussions.

          I don't think you're subhuman, but so far you've shown very little understanding in the arguments discussed on Slashdot this past year.

          • Actually I found his/her comments quite spot-on. In fact, your observations are so contrary to my experience on Slashdot since trump win in 2016, I have to ask what your motivations are? They're clearly not correcting the record. By the way I think anti vaxxers are morons equivalent to flat earthers myself, so please don't infer this to be a defense of that particular flavor of crazy.
            • Actually I found his/her comments quite spot-on. In fact, your observations are so contrary to my experience on Slashdot since trump win in 2016, I have to ask what your motivations are?

              Maybe you browse at -1 instead of +5. Antivaxxer morons don't stay modded up on Slashdot, much like the cheers for censorship don't.

          • the right to free speech is inseparably linked with the right to free association. No own owes you platform, and kicking you out of my house is not censorship.

            +5 enforcing the narrative that your ability to win elections should hinge on the willingness of a few oligarchs to "associate" with you.

          • No own owes you platform, and kicking you out of my house is not censorship.

            Consider if all consumer computing device makers colluded to deny platform to individual developers of free software, asserting anti-circumvention rights against anyone who publishes a method to run unapproved software. Would kicking free software out of the house be censorship?

            • What you're describing is not a speech issue so it's not censorship. What it would be is an antitrust issue is applied outside of someone one's vertical supplychain.

              Guess what, I can't run Notepad++ on an iPad, and that is not at all because of censorship.

              • by tepples ( 727027 )

                Consider if all consumer computing device makers colluded to deny platform to individual developers of free software

                What you're describing is not a speech issue so it's not censorship.

                Developing and publishing a computer program is speech. Bernstein v. United States [wikipedia.org].

                What it would be is an antitrust issue is applied outside of someone one's vertical supplychain.

                Or if several parallel vertical supply chains were to all apply a policy against free software. This is the case, for example, with Sony, Microsoft, Nintendo, and Apple, all of whose distribution policies are incompatible with copyleft.

                • Developing and publishing a computer program is speech. Bernstein v. United States [wikipedia.org].

                  The wonderful things about rulings is they come with context. Don't pretend you can take an isolated quote and therefore apply every law to it. Unless you like getting laughed out of court, because that's precisely how you get laughed out of court.

        • Merely questioning something like the Corona vaccine isn't allowed

          Stop with your gaslighting bullshit.

          Question it all you want. No one is stopping you. But yes, if you don't have at least some credible background or actual knowledge, no one is required to listen to your "theories" that you scraped from OAN or some Youtube channel. No one is required to take you seriously.

          You're like that ex-friend of mine who insists evolution is "fake" and the vaccines are fake and that Earth is only a few thousand years old, along with a ton of other crackpot ideas.

          How does he know? Bec

          • by KGIII ( 973947 )

            You can't reason someone out of a position they didn't reason themselves into.

            • You can't reason someone out of a position they didn't reason themselves into.

              Sad but true.

              In his case it's mostly due to his fundamentalist indoctrination as a child and and Republican indoctrination as a young adult.

        • My question is what are you or any of these "censored" folks questioning about the vaccine?
          I hear things like this.

          "nobody will tell us what is in it." False
          "bill gates is trying to control our minds with nanotech" False
          "the vaccine will give us auto-immune diseases" False
          "the vaccine will give you cancer" False.

          These are all real world assertions I have actually heard from people sitting in the chair next to me and not someone behind an electronic screen.

          So I suppose it depends upon what your actual q

      • by geekmux ( 1040042 ) on Sunday May 16, 2021 @04:08AM (#61389780)

        Does anyone want to actually discuss something nerdy about this topic or is this going to instantly devolve into anti-vax showboating.

        Sure, I'm game.

        How about we discuss the expert publishers and the psychology of the decision to announce "tiny injectible wireless chip" technology, while the inject-me-with-5G vaccine conspiracy tornado, is still ripping through a society gullible enough to believe it.

        During a pandemic.

        Which expert wants to go first?

        • I have the same concerns.

          This release is by Columbia university, the alma mater of Buffet, Obama, FDR, Allen Ginsberg & Jack Kerouac, which on the surface would seem to include at least some folks who'd question authority.

          The study and news release come from the Engineering Department: from the The Fu Foundation School of Engineering and Applied Science, formerly the Columbia School of Engineering and Applied Science, so named after after former student and Chinese businessman Z.Y. Fu donated $26 milli

        • Bingo. The timing of the announcement is a bit suspect, IMHO -- at the very least it shows incredibly poor judgement, and a lack of awareness regarding popular culture. Notice I did not say that popular culture was correct.

        • Would you prefer to keep this story a secret from the public until they are mature enough to handle it? And I'm sure when they find out it was kept a secret, the public will handle the News in calm and intelligent manner.
      • I have a hypothesis. I joined when I was a teenager and probably so did a large cohort. The prior adults started it for tech news and that's what it was back then. Politics isn't as interesting to a 16 year old. I'm 37 now, I've got a family, politics is more urgently interesting. But being into tech doesn't set your politics so we all diverged and polarised. Now most of my comments have probably been political because it is hard to sit by.
        • Seems like sound analysis & hypothesis. At the very least an interesting point to posit.

          I have been on SD for a while now. I was always a full adult from the beginning of SD, but I was reading it mostly for the tech articles.
          Political articles always cropped up and were hotly debated from the beginning.
          I think that the polarization that has evolved tracks with the polarization of society.

          Differences between people have always been there... the stridency is a bit more intense now is all.

      • Does anyone want to actually discuss something nerdy about this topic or is this going to instantly devolve into anti-vax showboating.

        Sadly, the latter is more likely.

        Some people just love to believe in bullshit no matter how dumb it is.

      • by Thaelon ( 250687 )

        >I am sure some bitter vets can step in and tell us about the good old days of genuine high quality nerd discourse.

        The quality of discussion hasn't changed one bit. A little more left wing authoritarian perhaps, but that's spreading like cancer recently. I say this as a registered Pacific Green. But quality wise it was was mostly shit, and it's still mostly shit.

      • by ami.one ( 897193 )

        100 % correct. It's become impossible to have any discussion online with the extreme polarization since the Trump vs Anti-Trump thing started.

        Even discussions with friends get screwed up now. For example the following link is pretty balanced investigation into the origin of covid and it only goes into human error or not territory (if you read it fully - bit long 20min read) But its always gonna get into conspiracy theory calls without people even reading it.
        https://science.thewire.in/the... [thewire.in]

        Same for the orig

        • That was a really good one. It exposed and highlighted the critical weakness of the virology community's objectivity about the source of the virus: money, and politics. Conflict of interest or lack thereof tends to be a better indicator of how accurate the experts are, given enough time or perhaps just for the statute of limitations to expire.

      • There are only two difference between current Slashdot and old Slashdot.

        1) there are fewer extremely good and extremely bad posts.

        2) People are paid to introduce disinformation now.

        There was plenty of ignorant and stupid shit back in 2001 (random date). It wasn't entirely some magical heaven of pleasant discourse... but yeah, the overall experience is less pleasant.

    • by gtall ( 79522 )

      So what? Cats have been controlling us for years and we don't see morons like you complaining about them.

    • I don't know, I have been vaccinated and it didn't really improve my 5G coverage... I feel this conspiracy technology does not live up to the rumor...

      • the G5 is polarized (like our country!).

        are you holding your arm up or holding it sideways?

        try it both ways to see which pulls in the better signal.

    • Yes. Not only were they put into the vaccines, 5G is being used to communicate to them and track us!

      Probably we need entire tinfoil armored suits to wear now! /s (for pete's sake)

    • You're just now realizing this?

      Just ask Bill Gates. Why do you think Melinda is divorcing him, other than the Jeffrey Epstein thing?

      To get control of half the vaxxed people of course. What, you think Bill can walk off with all billion drooling jackbrained drones? This is America buddy, she’s getting half.

    • by Z80a ( 971949 )

      You're suffering a case of "telephone" here.
      The original news is that bill gates suggested that people that got vaccinated also get a regular chip, like those you put in dogs so the stores etc can know who's vaxxed or not.
      It's a pretty awful idea, but it's not "chips in vaccines".

  • by Aighearach ( 97333 ) on Sunday May 16, 2021 @03:00AM (#61389660)

    0.1 mm is easily visible to the naked eye. And regardless of the total volume, the smallest visible dimension appears to be closer to 0.2mm.

    Whoever said it is only visible under a microscope should have asked somebody who doesn't wear glasses to verify that claim.

    • Unless you had a typo there, you just made the opposite point - you say 0.2 mm is the smallest visible dimension, and these are 0.1 mm.

      Anyway, what I found is this for the real limit at reasonable distance:

      https://en.m.wikipedia.org/wik... [wikipedia.org]

      50-100 microns, depending upon distance of course. So these are on the edge of visible.

      In general I'm not sure what the value is of declaring these smaller then the eye can see. I'm way more interested in what that size means within the body. Can they go in vein/arteries (

      • Unless you had a typo there

        I did not have a typo.

        If you're capable of parsing what I said, check if it makes sense; the total volume fits in 0.1mm3, supposedly; I think they rounded down heavily. But the smallest visible dimension is much larger. Hint: it isn't a cube, it is multiple rectangular prisms stuck together.

        You're just another idiot who doesn't listen carefully enough to understand what was said, but is ready to 'splain it back to me anyways.

        And you're as dumb as they are; you get your idea of what can be seen from a chart.

        • So when you said 0.1 mm did you mean 0.1 mm^3 is easy to see? That I agree with.

          The rest if you're response is an unnecessary string of insults, even if I had misread.

          • You can't see volume. You see one side of it. Something can have a relatively small total volume, but still be rather large from any viewing angle.

            This is not difficult. If you don't understand, stop pretending you do, and then crying that you get insulted for being intellectual dishonest. People who pretend they know shit, when they didn't even think about it, are lame and disgusting, and should be shot.

  • These things may be very small, but could they not cause blood clots or blockage of small arteries? What would happen in your kidneys/liver/brain?
    • Might worry about any artificially added particles in the bloodstream clumping up or depositing somewhere that would lead to some sort of significant problem.

      It is like when the industry started loading everything up with extra "Calcium" for the bones of old people. The additional calcium became problematic and started leading to greater arthritis due to calcium crystal deposition in joint spaces.

  • Not now (Score:3, Informative)

    by timematters ( 5083631 ) on Sunday May 16, 2021 @05:41AM (#61389864)

    Not a good time to come out with this research.

    • Yep. This announcement, once it gets out into the faux news, is going to retard vaccine uptake FOR SURE.

      Nice fucking timing.

    • by kackle ( 910159 )
      On the other hand, um, arm, stating that they're just building something like this means it was not in the millions of shots that have been given so far.

      "Get your shots now; they don't have the nanochips in them yet!"
  • by KreAture ( 105311 ) on Sunday May 16, 2021 @05:47AM (#61389872)
    In fact, easily visible.
    The thing is still HUGE in a body/cell situation. The only way I'd let that thing enter my body to avoid it being caught in the bloodstream and clogging something is by eating it.
    For those not realizing it, the thing is over half a mm tall. That's 0.57mm tall or 570m. Width and depth is 380x300m or 0.38x0.3mm.
    The largest you have in your blood is is a white monocyte blood cell and that can be up to 20m aka 0.02mm in diameter. The system is tuhs 28 times bigger.

    The amazing thing is that communication is possible when it is that small.

  • Fuck technology. It's killing us
  • by Cmdln Daco ( 1183119 ) on Sunday May 16, 2021 @07:02AM (#61389932)

    A big deal in medical devices has bee this thing called 'compliance monitoring.' The insurance company wants proof the the patient actually uses the device they (the insurance company) pay for.

    This could leak over into the actuaries at the insurance company also making use of it. Did you actually take the drug prescribed to you? Have you started smoking again? Sensors can be used to keep you a compliant patient.

  • We wanted to see how far we could push the limits on how small a functioning chip we could make.

    Notice the rationale for doing this had nothing to do with solving a specific problem in medial monitoring. It sounds a lot more like they thought making something as tiny as possible would have to be better, and people would think it's really cool and give them money. And of course, the people giving them money would have no idea what good any of this is either. But they did make it as small as possible!

  • I can't see this being abused at all?
  • by uhvuhvuhv ( 7221360 ) on Sunday May 16, 2021 @08:54AM (#61390154)
    Couldn't these scientists have sat on this for a year? How many anti-vax folks will die because this provided fuel for their conspiracy theory?
  • this was a show on mcguvyer
  • In addition to our fine selection of Tinfoil Hats and Underwear we are proud to introduce our new line of Tinfoil Suits. When you use our Tinfoil apparel and our Conductive Mylar Outerwear together you create a personal signal-free zone around your body.

  • I think it's interesting that they use ultrasound for both powering it and communication. I hadn't considered that RF would fail here because of the size of the object.

    I don't know the details of the ultrasound but I assume the downside of it is that you would need an ultrasound source and receiver nearby (at skin level?) to continuously monitor. So in that case the real power requirements are higher - these won't do anything until the (relatively) high-power ultrasound generator is present.

    Is thermoelectri

    • by PPH ( 736903 )

      Glucose powered fuel cell.

    • by ezdiy ( 2717051 )

      The temp gradients are too small for an object this tiny anywhere in your body to make enough potential. I think using the piezzo they already have for ultrasound could be also used for harvesting energy from pressure changes. Each heartbeat is a lot of energy in short time burst, enough to run for couple million ticks and then keep RAM alive until next beat -> pseudo-continuous low power mode whenever outside ultrasound range.

      As for RF, the problem isn't size as such, but sub-mm waves you'd have to use

  • "Conspiracy theorists, start your engines!!"

    And we're off....

  • This is absolutely the worst time to make such an announcement.

    Remember when this same story would have evoked nothing but a bunch of jocular comments about Raquel Welch in a submarine being shrunk down to microscopic size and traveling through your bloodstream?

  • Worst possible time to put out this article?

  • A third of the volume of that device is lead zirconate titanate, an alloy that consists of over 50% lead.

    While this might be excempt from RoHS as a medical device, some people might object to being injected with lead, so there are still some issues to overcome before mass deployment.

    It also uses a chromium is some places, but the amount of that is much lower than the lead zirconate titanate.

    • by ezdiy ( 2717051 )

      PZT is just cheap and efficient, pretty fine for a prototype. Medical-grade piezzo materials are already in use (BTO, PVDF, NIA, Quartz...), but are presumably much more expensive to fabricate on chip.

  • Now they'll point and screetch about how the 'tracking chips' are real, we'll never get them to STFU about it.
  • It is real now. Clench your ass cheeks, the AllThing microchip is coming!

The unfacts, did we have them, are too imprecisely few to warrant our certitude.

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