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Medicine

Exercising 25 Minutes a Week Increases Brain Volume - and May Slow Memory Decline (calgarysun.com) 62

"Exercising for 25 minutes a week, or less than four minutes a day, could help to bulk up our brains," reports the Washington Post, "and improve our ability to think as we grow older." A new study, which involved scanning the brains of more than 10,000 healthy men and women from ages 18 to 97, found that those who walked, swam, cycled or otherwise worked out moderately for 25 minutes a week had bigger brains than those who didn't, whatever their ages.

Bigger brains typically mean healthier brains. The differences were most pronounced in parts of the brain involved with thinking and memory, which often shrink as we age, contributing to risks for cognitive decline and dementia... The results have practical implications, too, about which types of exercise seem best for our brain health and how little of that exercise we may really need.

The article notes that the researchers used AI to assess brain scans from 10,125 "mostly healthy adults of all ages who'd come to the university medical center for diagnostic tests... A clear pattern quickly emerged." Men and women, of any age, who exercised for at least 25 minutes a week showed mostly greater brain volume than those who didn't. The differences weren't huge but were significant, said Cyrus A. Raji, an associate professor of radiology and neurology at Washington University in St. Louis, who led the new study, especially when the researchers looked deeper inside the organ. There, they found that exercisers possessed greater volume in every type of brain tissue, including gray matter, made up of neurons, and white matter, the brain's wiring infrastructure, which supports and connects the thinking cells. More granularly, the exercisers tended to have a larger hippocampus, a portion of the brain essential for memory and thinking. It usually shrinks and shrivels as we age, affecting our ability to reason and recall. They also showed larger frontal, parietal and occipital lobes, which, together, signal a healthy, robust brain...

Exactly how exercise might be altering brains is impossible to say from this study. But Raji and his colleagues believe exercise reduces inflammation in the brain and also encourages the release of various neurochemicals that promote the creation of new brain cells and blood vessels. In effect, exercise seems to help build and bank a "structural brain reserve," he said, a buffer of extra cells and matter that could protect us somewhat from the otherwise inevitable decline in brain size and function that occurs as we age. Our brains may still shrink and sputter over the years. But, if we exercise, this slow fall starts from a higher baseline...

Space

Astronomers Discover Giant Ancient Stars in Milky Way (theguardian.com) 25

Astronomers have discovered a mysterious group of giant elderly stars at the heart of the Milky Way that are emitting solar system-sized clouds of dust and gas. The stars, which have been named "old smokers," sat quietly for many years, fading almost to invisibility, before suddenly puffing out vast clouds of smoke. The discovery was made during the monitoring of almost a billion stars in infrared light during a 10-year survey of the night sky. The Guardian: The astronomers had set out to capture rarely seen newborn stars -- known as protostars -- while undergoing the equivalent of a stellar growth spurt. During these periods, young stars rapidly acquire mass by gorging on surrounding star-forming gas, leading to a sudden increase in luminosity. The team tracked hundreds of millions of stars and identified 32 erupting protostars that increased in brightness at least 40-fold and in some cases more than 300-fold.

Another group of red giant stars near the centre of the Milky Way unexpectedly showed up in the analysis, however. When they were studied in more detail using the European Southern Observatory's Very Large Telescope, seven of the stars were deemed to be a new type of red giant star, which the researchers named "old smokers." Convection currents and instabilities within the star could trigger the release of enormous columns of smoke, Prof Philip Lucas of the University of Hertfordshire, who led the observations, suggested.

NASA

NASA's Ingenuity Mission Is Over (nasa.gov) 73

cusco writes: After three years and 72 flights of its 5-flight mission the mission of the Ingenuity helicopter on Mars is finally over. Images show that Ingenuity suffered damage to one of its rotor blades and will not be able to take off again. NASA's press release, also shared by cusco: Ingenuity landed on Mars Feb. 18, 2021, attached to the belly of NASA's Perseverance rover and first lifted off the Martian surface on April 19, proving that powered, controlled flight on Mars was possible. After notching another four flights, it embarked on a new mission as an operations demonstration, serving as an aerial scout for Perseverance scientists and rover drivers. In 2023, the helicopter executed two successful flight tests that further expanded the team's knowledge of its aerodynamic limits.

[...] Over an extended mission that lasted for almost 1,000 Martian days, more than 33 times longer than originally planned, Ingenuity was upgraded with the ability to autonomously choose landing sites in treacherous terrain, dealt with a dead sensor, cleaned itself after dust storms, operated from 48 different airfields, performed three emergency landings, and survived a frigid Martian winter.

Designed to operate in spring, Ingenuity was unable to power its heaters throughout the night during the coldest parts of winter, resulting in the flight computer periodically freezing and resetting. These power "brownouts" required the team to redesign Ingenuity's winter operations in order to keep flying.

With flight operations now concluded, the Ingenuity team will perform final tests on helicopter systems and download the remaining imagery and data in Ingenuity's onboard memory. The Perseverance rover is currently too far away to attempt to image the helicopter at its final airfield.

Medicine

The Cancer That Doctors Don't Want to Call Cancer (wsj.com) 163

When is cancer not cancer? It's an unexpected question that has stirred the world of cancer treatment in recent years, most notably now with prostate cancer. WSJ: A growing number of doctors are advocating what might seem like an unusual position: That low-grade prostate cancers that grow very slowly or not at all shouldn't be called cancer or carcinoma. The reason, they say, is that those words scare men, their families and sometimes even their doctors into seeking more aggressive treatment than patients need -- leaving men with debilitating side effects -- rather than pursuing a carefully monitored wait-and-see approach.

A name change wouldn't be unprecedented. Certain other forms of thyroid, cervical and bladder cancers have been reclassified, sometimes partly to avoid scaring people about cancers that are unlikely to spread. "The word 'cancer' engenders so much anxiety and fear," says Dr. Laura Esserman, a professor of surgery and radiology at the University of California, San Francisco and director of its Breast Care Center, who is advocating for a type of lower-risk breast cancer to be renamed. "Patients think if I don't do something tomorrow, this is going to kill me. In fact, that's not true."

Science

Top Harvard Cancer Researchers Accused of Scientific Fraud; 37 Studies Affected (arstechnica.com) 172

An anonymous reader shares a report: The Dana-Farber Cancer Institute, an affiliate of Harvard Medical School, is seeking to retract six scientific studies and correct 31 others that were published by the institute's top researchers, including its CEO. The researchers are accused of manipulating data images with simple methods, primarily with copy-and-paste in image editing software, such as Adobe Photoshop. The accusations come from data sleuth Sholto David and colleagues on PubPeer, an online forum for researchers to discuss publications that has frequently served to spot dubious research and potential fraud. On January 2, David posted on his research integrity blog, For Better Science, a long list of potential data manipulation from DFCI researchers. The post highlighted many data figures that appear to contain pixel-for-pixel duplications. The allegedly manipulated images are of data such as Western blots, which are used to detect and visualize the presence of proteins in a complex mixture.

DFCI Research Integrity Officer Barrett Rollins told The Harvard Crimson that David had contacted DFCI with allegations of data manipulation in 57 DFCI-led studies. Rollins said that the institute is "committed to a culture of accountability and integrity," and that "every inquiry about research integrity is examined fully." The allegations are against: DFCI President and CEO Laurie Glimcher, Executive Vice President and COO William Hahn, Senior Vice President for Experimental Medicine Irene Ghobrial, and Harvard Medical School professor Kenneth Anderson. The Wall Street Journal noted that Rollins, the integrity officer, is also a co-author on two of the studies. He told the outlet he is recused from decisions involving those studies.

Medicine

New Blood Test That Screens For Alzheimer's May Be a Step Closer To Reality, Study Suggests (cnn.com) 75

Testing a person's blood for a type of protein called phosphorylated tau, or p-tau, could be used to screen for Alzheimer's disease with "high accuracy," even before symptoms begin to show, a new study suggests. CNN: The study involved testing blood for a key biomarker of Alzheimer's called p-tau217, which increases at the same time as other damaging proteins -- beta amyloid and tau -- build up in the brains of people with the disease. Currently, to identify the buildup of beta amyloid and tau in the brain, patients undergo a brain scan or spinal tap, which often can be inaccessible and costly. But this simple blood test was found to be up to 96% accurate in identifying elevated levels of beta amyloid and up to 97% accurate in identifying tau, according to the study published Monday in the journal JAMA Neurology.

"What was impressive with these results is that the blood test was just as accurate as advanced testing like cerebrospinal fluid tests and brain scans at showing Alzheimer's disease pathology in the brain," Nicholas Ashton, a professor of neurochemistry at the University of Gothenburg in Sweden and one of the study's lead authors, said in an email. The study findings came as no surprise to Ashton, who added that the scientific community has known for several years that using blood tests to measure tau or other biomarkers has the potential to assess Alzheimer's disease risk. "Now we are close to these tests being prime-time and this study shows that," he said. Alzheimer's disease, a brain disorder that affects memory and thinking skills, is the most common type of dementia, according to the National Institutes of Health.

Medicine

Gummy Vitamins Are Just Candy (theatlantic.com) 143

Gummy vitamin supplements have surged in popularity, with sales projected to double to $14 billion by 2027. However, experts warn that the candy-like taste and texture increase risks of overdosing, especially among children, as calls to Poison Control for melatonin overdoses have jumped 530% in a decade. Formulating vitamins into gummies also leads to faster nutrient degradation from heat, light and moisture than pills. Testing shows gummy vitamins often contain far more or less of ingredients than labels state. While some sweetness makes supplements appealing, gummies mimic candy too closely at the expense of safety and reliability. The Atlantic: A recent analysis of melatonin and CBD gummies yielded similar results: Some contained as much as 347 percent the amount of those substances stated on the label. Because the FDA generally does not regulate supplements as drugs, such wild variability is accepted in a way that it isn't for actual pharmaceuticals. (In 2020, the FDA granted the first-ever Investigational New Drug Application for a gummy medication, though no such product appears to have come to market.) "If you have something that you need a specific amount of every time you take it, gummies are not the way to go," says Pieter Cohen, a doctor at Cambridge Health Alliance, in Somerville, Massachusetts, and the lead author of the melatonin-CBD research. Taking too much of a supplement is generally not as dangerous as taking too much of a prescription drug, but, as Breuner noted, many supplements taken in sufficient excess can still be toxic. When I asked Cooperman what advice he had for people trying to navigate all of this, his answer was simple: "Don't buy a gummy."

Perhaps the rise of gummy supplements was inevitable. The supplement industry has become so big in part because it can promote its products as, say, boosting the immune system or supporting healthy bones, without subjecting them to the strict regulatory demands imposed on pharmaceuticals. Supplements blur the line between food and drug, and gummy supplements -- designed and marketed on the premise that healthy stuff can and should taste as good as candy -- only intensify that blurring. Cohen, for one, thinks the distinction is worth preserving. Calcium supplements should not go down as easy as Haribos. That may be a bitter pill to swallow, but not everything can taste like candy.

NASA

NASA Finally Unlocks Canister of Dust From 4.6 Billion-Year-Old Asteroid (theguardian.com) 47

NASA announced Friday that it finally got a canister of asteroid dust open, four months after it parachuted down through the Earth's atmosphere into the Utah desert. The Guardian reports: The space administration announced Friday that it had successfully removed two stuck fasteners that had prevented some of the samples collected in 2020 from the 4.6bn-year-old asteroid Bennu, which is classified as a "potentially hazardous" because it has one in 1,750 chance of crashing into Earth by 2300. Most of the rock samples collected by Nasa's Osiris-Rex mission were retrieved soon after the canister landed in September, but additional material remaining inside a sampler head that proved difficult to access.

After months of wrestling with the last two of 35 fasteners, scientists in Houston managed to get them dislodged. "It's open! It's open!" Nasa's planetary science division posted on Twitter/X. The division also posted a photograph of dust and small rocks inside the canister. According to the Los Angeles Times, the team designed custom tools made from a specific grade of surgical, non-magnetic stainless steel to pry it open -- all without the samples being contaminated by Earthly air. Nasa said it will now analyze the nine-ounce sample.

Medicine

CDC Now Encouraging Doctors To Consider More Blood Testing For 'Forever Chemicals' (go.com) 65

An anonymous reader quotes a report from ABC News: Doctors are now being encouraged to consider more blood testing for PFAS, also known as "forever chemicals," according to guidance released (PDF) by the Centers for Disease Control and Prevention (CDC). The federal agency is recommending providers have a discussion with their patients regarding consumer and environmental exposures to large levels of the chemicals, and if blood testing may be of benefit.

"This information is intended for individuals and communities around the country, who are concerned about exposure to PFAS to have productive conversations with their medical providers" Dr. Aaron Bernstein, Director of CDC's National Center for Environmental Health (NCEH) and the Agency for Toxic Substances and Disease Registry (ATSDR), told ABC News. "Over 90% of people in this country have been exposed to PFAS and many, many communities around the country there have been very high exposures. And we've learned more and more in recent years about how exposures to PFAS may increase risk for many disease" he added.

The new guidance advises providers to consider an individual's exposure history; the results of PFAS testing from a patient's water supply, food sources, or other exposures; and whether those results can inform regarding ways to reduce future exposures. Most Americans are exposed to PFAS through drinking water, according to Bernstein, who also notes that many municipal water agencies are already testing for PFAS, and those test results are typically publicly available. [...] While blood tests for PFAS may help guide exposure reduction or provide psychological relief to patients, such tests do not help identify the source of exposure, nor can they be directly linked to a health condition. There are also currently no approved medical treatments available to reduce PFAS in the body, according to the CDC.
"A PFAS level is one piece of data that needs to be taken in a broader context. We need to understand the individual's health history, their family history, what other exposures they may have that might increase the risk of diseases that can also be associated with PFAS," Bernstein said.

"What is clear is that this is an evolving landscape [...] we are at a point in time that both the science around PFAS, the accessibility of testing, and what is being tested for is changing. We are committed at CDC to stay on top of it and update this information as needed."
Japan

Japan's Successful Moon Landing Was the Most Precise Ever (nature.com) 32

Japan has become the fifth country in the world to soft-land a spacecraft on the Moon, using precision technology that allowed it to touch down closer to its target landing site than any mission has before. However the spacecraft might have survived on the lunar surface for just a few hours due to power failure. Nature: Telemetry showed that the Smart Lander for Investigating Moon, or SLIM, touched down in its target area near Shioli crater, south of the lunar equator early Saturday morning, four months after lifting off from the Tanegashima Space Centre, off the south coast of Japan. [...] According to [Hitoshi] Kuninaka (VP of Kanegawa-based Japan Aerospace Exploration Agency), SLIM has very likely achieved its primary goal -- to land on the Moon with an unprecedented accuracy of 100 metres, which is a big leap from previous ranges of a few to dozens of kilometres. SLIM carried vision-based navigation technology, which was intended to image the surface as it flew over the Moon, and locate itself quickly by matching the images with onboard maps.

It remains unclear if the car-sized, 200-kilogram spacecraft actually touched down in the planned, two-step manner with its five legs. Unlike previous Moon landers, which used four legs to simultaneously reach a relatively flat area, SLIM was designed to hit a 15-degree slope outside Shioli crater first with one leg at the back, and then tip forward to stabilize on the four front legs. Observers suggest that SLIM might have rolled during its touch-down, preventing its solar cells from facing the Sun. Kuninaka said not enough data were available to establish the probe's posture or orientation. However, if some sunlight is able to reach the solar cells there is a chance that SLIM could come back to life.

Medicine

Cameroon Starts World-First Malaria Mass Vaccine Rollout (bbc.com) 54

The world's first routine vaccine programme against malaria has started in Cameroon, in a move projected to save thousands of children's lives across Africa. From a report: The symbolic first jab was given to a baby girl named Daniella at a health facility near Yaounde on Monday. Every year 600,000 people die of malaria in Africa, according to the World Health Organization (WHO). Children under five make up at least 80% of those deaths. Cameroon is offering the RTS,S vaccine free of charge to all infants up to the age of six months old.

Patients require a total of four doses. Health officials say these will be given at the same time as other routine childhood vaccines to make it easier for parents. It comes after successful pilot campaigns in Kenya, Ghana and Malawi - where the vaccine caused a 13% drop in malaria deaths in children of eligible age, says Unicef. The jab is known to be effective in at least 36% of cases, according to US researchers, meaning it could save over one in three lives. While the rollout is undoubtedly a relief and a life-saver, its relatively low efficacy rate means that it is not a "silver bullet," argues Willis Akhwale at End Malaria Council Kenya.

Biotech

Potential Cancer Vaccine Entering Stage 3 Trials (go.com) 71

Slashdot reader quonset writes: After decades of study and testing, a potential vaccine for cancer may be on the horizon. Dr. Thomas Wagner, founder of Orbis Health Solutions, is using the body's own immune system to fight the disease, with each shot personalized to the patient, according to ABC News.
From the article: Typically, cancer cells evade a person's immune system because it is recognized as that person's cells. Wagner developed a tumor lysate particle only (TLPO) vaccine that uses a person's tumor cells to identify particular parts that are then presented back in the body using the vaccine in a way that can stimulate their immune system to gain the ability to detect these cancer cells like an infection, allowing the immune system to fight the cancer itself.

"People used to ask me the question, 'When will there be a cure for cancer?' And I've been doing this for 60 years and I could never answer that question," Wagner said. "Until recently, until the last three or four or five years." Wagner believes this type of cancer treatment could be a key to finding the long-awaited cure for cancer, all cancers, if paired with early detection.

Wagner's TLPO cancer vaccine has been tested in hundreds of patients with advanced forms of melanoma in Phase 2 clinical trials. The most recent data presented at an academic conference showed nearly 95% of people given only the vaccine were still alive three years after starting treatment and 64% were still disease-free. Among the most advanced forms of melanoma, disease-free survival after three years for people with stage III disease was 60% in the vaccine-only group, compared to about 39% in the placebo group. Disease-free survival for those with stage IV disease was about 68% in the vaccine-only group, and zero in the placebo group.

The most common side effects were redness or pain at the injection site, fever and fatigue after the injection – similar to other vaccines that stimulate an immune response.

Based on this data and other studies, the U.S. Food and Drug Administration has greenlit Wagner's vaccine to start a Phase 3 clinical trial. It will be a three-year endeavor with a goal to enroll 500 people and is planned to launch sometime this year, Riley Polk, president of Orbis Health Solutions, told WLOS, an ABC News affiliate in Asheville, North Carolina.

Polk's own father was told there were no treatment options left for his lung cancer, according to the article. That was more than 10 years ago, and "His father opted to try Wagner's cancer vaccine and lived 10 more years before dying from something unrelated to cancer." Polk gives ABC News this quote.

"You can tell me a lot of things, but you can't tell me [the vaccine] doesn't work."
Mars

NASA Regains Contact With Its 'Ingenuity' Mars Helicopter (npr.org) 12

"Good news..." NASA posted Saturday night on X. "We've reestablished contact with the Mars Helicopter..."

After a two-day communications blackout, NASA had instructed its Perseverance Mars rover "to perform long-duration listening sessions for Ingenuity's signal" — and apparently they did the trick. "The team is reviewing the new data to better understand the unexpected comms dropout" during the helicopter's record-breaking 72nd flight.

Slashdot reader Thelasko shared this report from NPR: Communications broke down on Thursday, when the little autonomous rotorcraft was sent on a "quick pop-up vertical flight," to test its systems after an unplanned early landing during its previous flight, the agency said in a status update on Friday night. The Perseverance rover, which relays data between the helicopter and Earth during the flights, showed that Ingenuity climbed to its assigned maximum altitude of 40 feet, NASA said.

During its planned descent, the helicopter and rover stopped communicating with each other...

Even before it came back online, RockDoctor (Slashdot reader #15,477) pointed out that the Mars copter has done this before. "Batteries dieing, resulting in a communications re-set, If I remember correctly."

Space.com also noted additional alternatives: "Perseverance is currently out of line-of-sight with Ingenuity, but the team could consider driving closer for a visual inspection," NASA's Jet Propulsion Laboratory in Southern California, which manages both robots' missions, said via X on Friday.

Ingenuity has stayed aloft for more than 128 minutes and covered a total of 11 miles (17.7 kilometers) during its 72 Mars flights, according to the mission's flight log.

Medicine

How Scientists are Fighting Drug-Resistant Superbugs with Phages (cnn.com) 39

"It's ridiculous just how virulent some of these bacteria get over time," says Dwayne Roach, assistant professor of bacteriophages, infectious disease and immunology at San Diego State University.

But now CNN says doctors are fighting multi-drug-resistant superbugs with "nature's oldest predators — tiny tripod-looking viruses called phages designed to find, attack and gobble up bacteria." The microscopic creatures have saved the lives of patients dying from superbug infections and are being used in clinical trials as a potential solution to the growing problem of antibiotic resistance...

In labs around the country, phage scientists are taking research and discovery to the next level... [Yale scientists] are busy mapping which phages and antibiotics are most symbiotic in the fight against a pathogen. Roach's San Diego State lab is investigating the body's immune response to phages while developing new phage purification techniques to prepare samples for intravenous use in patients. Currently, clinical trials are underway to test the effectiveness of phages against intractable urinary tract infections, chronic constipation, joint infections, diabetic foot ulcers, tonsillitis and the persistent, reoccurring infections that occur in patients with cystic fibrosis. The chronic infections common in cystic fibrosis are typically due to various strains of drug-resistant Pseudomonas aeruginosa — the same pathogen responsible for Horton's ear infection and the artificial tears outbreak.

A number of labs are developing libraries of phages, stockpiled with strains found in nature that are known to be effective against a particular pathogen. In Texas, a new facility is taking that a step further — speeding up evolution by creating phages in the lab. "Rather than just sourcing new phages from the environment, we have a bioreactor that in real time creates billions upon billions of phages," said Anthony Maresso, associate professor at Baylor College of Medicine in Houston. "Most of those phages won't be active against the drug-resistant bacteria, but at some point there will be a rare variant that has been trained, so to speak, to attack the resistant bacteria, and we'll add that to our arsenal," Maresso said. "It's a next-generation approach on phage libraries." Maresso's lab published a study last year on the treatment of 12 patients with phages customized to each patient's unique bacterial profile. It was a qualified success: The antibiotic-resistant bacteria in five patients were eradicated, while several more patients showed improvements.

"There's a lot of approaches right now that are happening in parallel," Roach said. "Do we engineer phages? Do we make a phage cocktail, and then how big is the cocktail? Is it two phages or 12 phages? Should phages be inhaled, applied topically or injected intravenously? There's a lot of work underway on exactly how to best do this...." Genetically engineering phages would allow scientists to target each person's unique mix of antibiotic-resistant pathogens instead of searching sewage, bogs, ponds, the bilge of boats and other prime breeding grounds for bacteria to find just the right phage for the job.

Along with phage libraries, genetic engineering is also a key to churning out phages in mass, to distribute on a wider scale. In Russia and the country of Georgia, where phage therapy has been used for decades, patients can buy phage cocktails off the shelf in pharmacies.

Space

Nearby Galaxy's Giant Black Hole Is Real, 'Shadow' Image Confirms (science.org) 30

"A familiar shadow looms in a fresh image of the heart of the nearby galaxy M87," reports Science magazine.

"It confirms that the galaxy harbors a gravitational sinkhole so powerful that light cannot escape, one generated by a black hole 6.5 billion times the mass of the Sun." But compared with a previous image from the network of radio dishes called the Event Horizon Telescope (EHT), the new one reveals a subtle shift in the bright ring surrounding the shadow, which could provide clues to how gases churn around the black hole. "We can see that shift now," says team member Sera Markoff of the University of Amsterdam. "We can start to use that." The new detail has also whetted astronomers' desire for a proposed expansion of the EHT, which would deliver even sharper images of distant black holes.

The new picture, published this week in Astronomy & Astrophysics, comes from data collected 1 year after the observing campaign that led to the first-ever picture of a black hole, revealed in 2019 and named as Science's Breakthrough of the Year. The dark center of the image is the same size as in the original image, confirming that the image depicts physical reality and is not an artifact. "It tells us it wasn't a fluke," says Martin Hardcastle, an astrophysicist at the University of Hertfordshire who was not involved in the study. The black hole's mass would not have grown appreciably in 1 year, so the comparison also supports the idea that a black hole's size is determined by its mass alone. In the new image, however, the brightest part of a ring surrounding the black hole has shifted counterclockwise by about 30 degrees.

That could be because of random churning in the disk of material that swirls around the black hole's equator. It could also be associated with fluctuations in one of the jets launched from the black hole's poles — a sign that the jet isn't aligned with the black hole's spin axis, but precesses around it like a wobbling top. That would be "kind of exciting," Markoff says. "The only way to know is to keep taking pictures...."

[T]he team wants to add more telescopes to the network, which would further sharpen its images and enable it to see black holes in more distant galaxies.

Thanks to Slashdot reader sciencehabit for sharing the news.
Space

Ultra-Large Structure Discovered In Distant Space Challenges Cosmological Principle (scitechdaily.com) 60

"The discovery of a second ultra-large structure in the remote universe has further challenged some of the basic assumptions about cosmology," writes SciTechDaily: The Big Ring on the Sky is 9.2 billion light-years from Earth. It has a diameter of about 1.3 billion light-years, and a circumference of about four billion light-years. If we could step outside and see it directly, the diameter of the Big Ring would need about 15 full Moons to cover it.

It is the second ultra-large structure discovered by University of Central Lancashire (UCLan) PhD student Alexia Lopez who, two years ago, also discovered the Giant Arc on the Sky. Remarkably, the Big Ring and the Giant Arc, which is 3.3 billion light-years across, are in the same cosmological neighborhood — they are seen at the same distance, at the same cosmic time, and are only 12 degrees apart on the sky. Alexia said: "Neither of these two ultra-large structures is easy to explain in our current understanding of the universe. And their ultra-large sizes, distinctive shapes, and cosmological proximity must surely be telling us something important — but what exactly?

"One possibility is that the Big Ring could be related to Baryonic Acoustic Oscillations (BAOs). BAOs arise from oscillations in the early universe and today should appear, statistically at least, as spherical shells in the arrangement of galaxies. However, detailed analysis of the Big Ring revealed it is not really compatible with the BAO explanation: the Big Ring is too large and is not spherical." Other explanations might be needed, explanations that depart from what is generally considered to be the standard understanding in cosmology...

And if the Big Ring and the Giant Arc together form a still larger structure then the challenge to the Cosmological Principle becomes even more compelling... Alexia said, "From current cosmological theories we didn't think structures on this scale were possible. "

Possible explanations include a Conformal Cyclic Cosmology, or the effect of cosmic strings passing through...

Thanks to long-time Slashdot reader schwit1 for sharing the article.
Space

James Webb Telescope Detects Earliest Known Black Hole (npr.org) 7

The Hubble Space Telescope's discovery of GN-z11 in 2016 marked it as the most distant galaxy known at that time, notable for its unexpected luminosity despite its ancient formation just 400 million years after the Big Bang. Now, in a paper published in Nature, astrophysicist Roberto Maiolino proposes that this brightness could be due to a supermassive black hole, challenging current understanding of early black hole formation and growth. NPR reports: This wasn't just any black hole. First -- assuming that the black hole started out small -- it could be devouring matter at a ferocious rate. And it would have needed to do so to reach its massive size. "This black hole is essentially eating the [equivalent of] an entire Sun every five years," says Maiolino. "It's actually much higher than we thought could be feasible for these black holes." Hence the word "vigorous" in the paper's title. Second, the black hole is 1.6 million times the mass of our Sun, and it was in place just 400 million years after the dawn of the universe. "It is essentially not possible to grow such a massive black hole so fast so early in the universe," Maiolino says. "Essentially, there is not enough time according to classical theories. So one has to invoke alternative scenarios."

Here's scenario one -- rather than starting out small, perhaps supermassive black holes in the early universe were simply born big due to the collapse of vast clouds of primordial gas. Scenario two is that maybe early stars collapsed to form a sea of smaller black holes, which could have then merged or swallowed matter way faster than we thought, causing the resulting black hole to grow quickly. Or perhaps it's some combination of both. In addition, it's possible that this black hole is harming the growth of the galaxy GN-z11. That's because black holes radiate energy as they feed. At such a high rate of feasting, this energy could sweep away the gas of the host galaxy. And since stars are made from gas, it could quench star formation, slowly strangling the galaxy. Not to mention that without gas, the black hole wouldn't have anything to feed on and it too would die.

Mars

Water Ice Buried At Mars' Equator Is Over 2 Miles Thick (space.com) 55

Keith Cooper reports via Space.com: A European Space Agency (ESA) probe has found enough water to cover Mars in an ocean between 4.9 and 8.9 feet (1.5 and 2.7 meters) deep, buried in the form of dusty ice beneath the planet's equator. The finding was made by ESA's Mars Express mission, a veteran spacecraft that has been engaged in science operations around Mars for 20 years now. While it's not the first time that evidence for ice has been found near the Red Planet's equator, this new discovery is by far the largest amount of water ice detected there so far and appears to match previous discoveries of frozen water on Mars.

"Excitingly, the radar signals match what we expect to see from layered ice and are similar to the signals we see from Mars' polar caps, which we know to be very ice rich," said lead researcher Thomas Watters of the Smithsonian Institution in the United States in an ESA statement. The deposits are thick, extended 3.7km (2.3) miles underground, and topped by a crust of hardened ash and dry dust hundreds of meters thick. The ice is not a pure block but is heavily contaminated by dust. While its presence near the equator is a location more easily accessible to future crewed missions, being buried so deep means that accessing the water-ice would be difficult.

Japan

Japan's SLIM Probe Lands On Moon, But Suffers Power Problem (space.com) 17

Geoffrey.landis writes: The Japan SLIM spacecraft has successfully landed on moon, but power problems mean it may be short mission. The good news is that the landing was successful, making Japan only the fifth nation to successfully make a lunar landing, and the ultra-miniature rover and the hopper both deployed. The bad news is that the solar arrays aren't producing power, and unless they can fix the problem in the next few hours, the batteries will be depleted and it will die. But, short mission or long, hurrah for Japan for being the fifth country to successfully land a mission on the surface of the moon (on their third try; two previous missions didn't make it). It's a rather amazing mission. I've never seen a spacecraft concept that lands under rocket power vertically but then rotates over to rest horizontally on the surface.
Science

Why Every Coffee Shop Looks the Same (theguardian.com) 67

An anonymous reader shares a report: These cafes had all adopted similar aesthetics and offered similar menus, but they hadn't been forced to do so by a corporate parent, the way a chain like Starbucks replicated itself. Instead, despite their vast geographical separation and total independence from each other, the cafes had all drifted toward the same end point. The sheer expanse of sameness was too shocking and new to be boring. Of course, there have been examples of such cultural globalisation going back as far as recorded civilisation. But the 21st-century generic cafes were remarkable in the specificity of their matching details, as well as the sense that each had emerged organically from its location. They were proud local efforts that were often described as "authentic," an adjective that I was also guilty of overusing. When travelling, I always wanted to find somewhere "authentic" to have a drink or eat a meal.

If these places were all so similar, though, what were they authentic to, exactly? What I concluded was that they were all authentically connected to the new network of digital geography, wired together in real time by social networks. They were authentic to the internet, particularly the 2010s internet of algorithmic feeds. In 2016, I wrote an essay titled Welcome to AirSpace, describing my first impressions of this phenomenon of sameness. "AirSpace" was my coinage for the strangely frictionless geography created by digital platforms, in which you could move between places without straying beyond the boundaries of an app, or leaving the bubble of the generic aesthetic. The word was partly a riff on Airbnb, but it was also inspired by the sense of vaporousness and unreality that these places gave me. They seemed so disconnected from geography that they could float away and land anywhere else. When you were in one, you could be anywhere.

My theory was that all the physical places interconnected by apps had a way of resembling one another. In the case of the cafes, the growth of Instagram gave international cafe owners and baristas a way to follow one another in real time and gradually, via algorithmic recommendations, begin consuming the same kinds of content. One cafe owner's personal taste would drift toward what the rest of them liked, too, eventually coalescing. On the customer side, Yelp, Foursquare and Google Maps drove people like me -- who could also follow the popular coffee aesthetics on Instagram -- toward cafes that conformed with what they wanted to see by putting them at the top of searches or highlighting them on a map. To court the large demographic of customers moulded by the internet, more cafes adopted the aesthetics that already dominated on the platforms. Adapting to the norm wasn't just following trends but making a business decision, one that the consumers rewarded. When a cafe was visually pleasing enough, customers felt encouraged to post it on their own Instagram in turn as a lifestyle brag, which provided free social media advertising and attracted new customers. Thus the cycle of aesthetic optimisation and homogenisation continued.

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