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Earth

Earth on Verge of Five Catastrophic Climate Tipping Points, Scientists Warn (theguardian.com) 234

Many of the gravest threats to humanity are drawing closer, as carbon pollution heats the planet to ever more dangerous levels, scientists have warned. From a report: Five important natural thresholds already risk being crossed, according to the Global Tipping Points report, and three more may be reached in the 2030s if the world heats 1.5C (2.7F) above pre-industrial temperatures. Triggering these planetary shifts will not cause temperatures to spiral out of control in the coming centuries but will unleash dangerous and sweeping damage to people and nature that cannot be undone.

"Tipping points in the Earth system pose threats of a magnitude never faced by humanity," said Tim Lenton, from the University of Exeter's Global Systems Institute. "They can trigger devastating domino effects, including the loss of whole ecosystems and capacity to grow staple crops, with societal impacts including mass displacement, political instability and financial collapse." The tipping points at risk include the collapse of big ice sheets in Greenland and the West Antarctic, the widespread thawing of permafrost, the death of coral reefs in warm waters, and the collapse of one atmospheric current in the North Atlantic.

NASA

SpaceX Plans Key NASA Demonstration For Next Starship Launch (cnbc.com) 15

SpaceX's next test of its Starship rocket is expected to include "a propellant transfer demonstration." CNBC reports: SpaceX last month launched its second Starship flight, a test which saw the company make progress in development of the monster rocket yet fall short of completing the full mission. The propellant transfer demonstration would require that the rocket reach orbit as one of the demo's goals. A successful attempt would push Starship beyond its benchmarks reached thus far. "NASA and SpaceX are reviewing options for the demonstration to take place during an integrated flight test of Starship and the Super Heavy rocket. However, no final decisions on timing have been made," NASA spokesperson Jimi Russell said in a statement to CNBC.

The "propellant transfer demonstration" falls under a NASA "Tipping Point" contract that the agency awarded SpaceX in 2020 for $53.2 million. As part of the contract, NASA wants SpaceX to develop and test "Cryogenic Fluid Management" (CFM) technology, which the agency notes is essential for future missions to the moon and Mars. [...] Under the NASA contract, SpaceX's first demo will involve transferring 10 metric tons of liquid oxygen between tanks within the Starship rocket. While Starship won't be rendezvousing with another tanker rocket for this demo, NASA considers the test progress in maturing the tech. "The goal is to advance cryogenic fluid transfer and fill level gauging technology through technology risk assessment, design and prototype testing, and in-orbit demonstration. The demonstration will decrease key risks for large-scale propellant transfer in the lead-up to future human spaceflight missions," NASA says.

Space

'Wobbly Spacetime' May Help Resolve Contradictory Physics Theories (theguardian.com) 90

Scientists have proposed a framework that they say could unify quantum mechanics and Albert Einstein's theory of general relatively. "Quantum theory and Einstein's theory of general relativity are mathematically incompatible with each other, so it's important to understand how this contradiction is resolved," said Prof Jonathan Oppenheim, a physicist at University College London, who is behind the theory. The Guardian reports: Until now, the prevailing assumption has been that Einstein's theory of gravity must be modified, or "quantized," in order to fit within quantum theory. This is the approach of string theory, which advances the view that spacetime comprises 10, 11 or possibly 26 dimensions. Another leading candidate, advanced by Rovelli and others, is loop quantum gravity, in which spacetime is composed of finite loops woven into an extremely fine fabric. Oppenheim's theory, published in the journal Physical Review X, challenges the consensus by suggesting that spacetime may be classical and not governed by quantum theory at all. This means spacetime, however closely you zoomed in on it, would be smooth and continuous rather than "quantized" into discrete units. However, Oppenheim introduces the idea that spacetime is also inherently wobbly, subject to random fluctuations that create an intrinsic breakdown in predictability.

"The rate at which time flows is changing randomly and fluctuating in time," said Oppenheim, although he clarifies that time would never actually go into reverse. "It's quite mathematical," he added. "Picturing it in your head is quite difficult." This proposed "wobbliness" would result in a breakdown of predictability, which, Oppenheim says, "many physicists don't like." [...]

Ultimately, whether the theory is correct is not an aesthetic preference, but a question of whether it is a faithful representation of reality. A second paper, published simultaneously in Nature Communications and led by Dr Zach Weller-Davies, formerly of UCL and now at Canada's Perimeter Institute, proposes an experiment designed to uncover "wobbles" in spacetime through tiny fluctuations in the weight of an object. For example, the International Bureau of Weights and Measures in France routinely weigh a 1kg mass, which used to be the 1kg standard. If the fluctuations in measurements of this 1kg mass are smaller than a certain threshold, the theory can be ruled out. "We have shown that if spacetime doesn't have a quantum nature, then there must be random fluctuations in the curvature of spacetime which have a particular signature that can be verified experimentally," said Weller-Davies.

Math

US Students' Math Scores Plunge In Global Education Assessment (axios.com) 131

Ivana Saric reports via Axios: U.S. students lag behind their peers in many industrialized countries when it comes to math, according to the results of a global exam released Tuesday. U.S. students saw a 13-point drop in their 2022 Program for International Student Assessment (PISA) math results when compared to the 2018 exam. The 2022 math score was not only lower than it was in 2012 but it was "among the lowest ever measured by PISA in mathematics" for the U.S., per the Organisation for Economic Co-operation and Development (OECD) country note. The 2018 PISA assessment found that U.S. students straggled behind their peers in East Asia and Europe, per the Washington Post.

PISA examines the proficiency of 15-year-olds in reading, mathematics, and science worldwide. The 2022 PISA edition is the first to take place since the pandemic and compares the test results of nearly 700,000 students across 81 OECD member states and partner economies. The exam, coordinated by the OECD, was first administered in 2000 and is conducted every three years. Due to the COVID-19 pandemic, the 2021 test was delayed until 2022.
What about the rest of the world? According to Axios, a total of 31 countries and economies "maintained or improved upon their 2018 math scores, including Switzerland and Japan."

"10 countries and economies -- Canada, Denmark, Finland, Hong Kong, Ireland, Japan, Korea, Latvia, Macao and the U.K. -- saw their students score proficiently in all three domains and had 'high levels of socio-economic fairness,'" the report adds.
Moon

India Reveals That It Has Returned Lunar Spacecraft To Earth Orbit 18

An anonymous reader shares a report: A little more than three months ago the Indian space agency, ISRO, achieved a major success by putting its Vikram lander safely down on the surface of the Moon. In doing so India became the fourth country to achieve a soft landing on the Moon, and this further ignited the country's interest in space exploration. But it turns out that is not the end of the story for the Chandrayaan 3 mission. In a surprise announcement made Monday, ISRO announced that it has successfully returned the propulsion module used by the spacecraft into a high orbit around Earth. This experimental phase of the mission, the agency said in a statement, tested key capabilities needed for future lunar missions, including the potential for returning lunar rocks to Earth.
Medicine

Research Finds That Renting Ages You Faster Than Smoking, Obesity 267

schwit1 shares a report from the New York Post: A landmark study out of the University of Adelaide and University of Essex has found that living in a private rental property accelerates the biological aging process by more than two weeks every year. The research found renting had worse effects on biological age than being unemployed (adding 1.4 weeks per year), obesity (adding 1 week per year), or being a former smoker (adding about 1.1 weeks). University of Adelaide Professor of Housing Research Emma Baker said private renting added "about two-and-a-half weeks of aging" per year to a person's biological clock, compared to those who own their homes.

"In fact, private rental is the really interesting thing here, because social renters, for some reason, don't seem to have that effect," Professor Baker told the ABC News Daily podcast. She said the security of social renting -- aka public housing -- and homeownership has compared to people living with an end-of-lease date on their calendars. "When you look at big studies of the Australian population, you see that the average rental lease is between six and 12 months," she said. "So even if you have your lease extended, you still are living in that slight state of kind of unknowingness, really not quite secure if your lease is actually going to be extended or not." "We think that that is one of the things that's contributing to loss of years, effectively."
Bug

Cicadas Are So Loud, Fiber Optic Cables Can 'Hear' Them (wired.com) 22

An anonymous reader quotes a report from Wired: One of the world's most peculiar test beds stretches above Princeton, New Jersey. It's a fiber optic cable strung between three utility poles that then runs underground before feeding into an "interrogator." This device fires a laser through the cable and analyzes the light that bounces back. It can pick up tiny perturbations in that light caused by seismic activity or even loud sounds, like from a passing ambulance. It's a newfangled technique known as distributed acoustic sensing, or DAS. Because DAS can track seismicity, other scientists are increasingly using it to monitor earthquakes and volcanic activity. (A buried system is so sensitive, in fact, that it can detect people walking and driving above.) But the scientists in Princeton just stumbled upon a rather noisier use of the technology.

In the spring of 2021, Sarper Ozharar -- a physicist at NEC Laboratories, which operates the Princeton test bed -- noticed a strange signal in the DAS data. "We realized there were some weird things happening," says Ozharar. "Something that shouldn't be there. There was a distinct frequency buzzing everywhere." The team suspected the "something" wasn't a rumbling volcano -- not inNew Jersey -- but the cacophony of the giant swarm of cicadas that had just emerged from underground, a population known as Brood X. A colleague suggested reaching out to Jessica Ware, an entomologist and cicada expert at the American Museum of Natural History, to confirm it. "I had been observing the cicadas and had gone around Princeton because we were collecting them for biological samples," says Ware. "So when Sarper and the team showed that you could actually hear the volume of the cicadas, and it kind of matched their patterns, I was really excited."

Add insects to the quickly growing list of things DAS can spy on. Thanks to some specialized anatomy, cicadas are the loudest insects on the planet, but all sorts of other six-legged species make a lot of noise, like crickets and grasshoppers. With fiber optic cables, entomologists might have stumbled upon a powerful new way to cheaply and constantly listen in on species -- from afar. "Part of the challenge that we face in a time when there's insect decline is that we still need to collect data about what population sizes are, and what insects are where," says Ware. "Once we are able to familiarize ourselves with what's possible with this type of remote sensing, I think we can be really creative."

Science

Physicists May Have Found a Hard Limit on The Performance of Large Quantum Computers (sciencealert.com) 71

For circuit-based quantum computations, the achievable circuit complexity is limited by the quality of timekeeping. That's according to a new analysis published in the journal Physical Review Letters exploring "the effect of imperfect timekeeping on controlled quantum dynamics."

An announcement from the Vienna University of Technology explains its significance. "The research team was able to show that since no clock has an infinite amount of energy available (or generates an infinite amount of entropy), it can never have perfect resolution and perfect precision at the same time. This sets fundamental limits to the possibilities of quantum computers."

ScienceAlert writes: While the issue isn't exactly pressing, our ability to grow systems based on quantum operations from backroom prototypes into practical number-crunching behemoths will depend on how well we can reliably dissect the days into ever finer portions. This is a feat the researchers say will become increasingly more challenging...

"Time measurement always has to do with entropy," says senior author Marcus Huber, a systems engineer who leads a research group in the intersection of Quantum Information and Quantum Thermodynamics at the Vienna University of Technology. In their recently published theorem, Huber and his team lay out the logic that connects entropy as a thermodynamic phenomenon with resolution, demonstrating that unless you've got infinite energy at your fingertips, your fast-ticking clock will eventually run into precision problems. Or as the study's first author, theoretical physicist Florian Meier puts it, "That means: Either the clock works quickly or it works precisely — both are not possible at the same time...."

[F]or technologies like quantum computing, which rely on the temperamental nature of particles hovering on the edge of existence, timing is everything. This isn't a big problem when the number of particles is small. As they increase in number, the risk any one of them could be knocked out of their quantum critical state rises, leaving less and less time to carry out the necessary computations... This appears to be the first time researchers have looked at the physics of timekeeping itself as a potential obstacle. "Currently, the accuracy of quantum computers is still limited by other factors, for example the precision of the components used or electromagnetic fields," says Huber. "But our calculations also show that today we are not far from the regime in which the fundamental limits of time measurement play the decisive role."

Earth

Plants May Be Absorbing 20% More CO2 Than We Thought, New Models Find (newatlas.com) 81

An anonymous reader writes: Using realistic ecological modeling, scientists led by Western Sydney University's Jürgen Knauer found that the globe's vegetation could actually be taking on about 20% more of the CO2 humans have pumped into the atmosphere and will continue to do so through to the end of the century.

"What we found is that a well-established climate model that is used to feed into global climate assessments by the likes of the IPCC (Intergovernmental Panel on Climate Change) predicts stronger and sustained carbon uptake until the end of the 21st century when extended to account for the impact of some critical physiological processes that govern how plants conduct photosynthesis," said Knauer.

Mathematical models of ecological systems are used to understand complex ecological processes and in turn attempt to predict how the real ecosystems they're based on will change. The researchers found that the more complex their modeling, the more surprising the results – in the environment's favor.

Current models, the team adds, are not that complex so likely underestimate future CO2 uptake by vegetation... [T]he modeling makes a strong case for the value of greening projects and their importance in comprehensive approaches to tackling global warming.

Science

Tiny Living Robots Made From Human Cells Surprise Scientists (cnn.com) 14

"Scientists have created tiny living robots from human cells," reports CNN. The mini-bots "can move around in a lab dish and may one day be able to help heal wounds or damaged tissue, according to a new study. "

The study's lead author tells CNN, "We don't realize all the competencies that our own body cells have." A team at Tufts University and Harvard University's Wyss Institute have dubbed these creations anthrobots. The research builds on earlier work from some of the same scientists, who made the first living robots, or xenobots, from stem cells sourced from embryos of the African clawed frog (Xenopus laevis)...

The scientists used adult human cells from the trachea, or windpipe, from anonymous donors of different ages and sexes... The tracheal cells are covered with hairlike projections called cilia that wave back and forth. They usually help the tracheal cells push out tiny particles that find their way into air passages of the lungs. Earlier studies had also shown that the cells can form organoids — clumps of cells widely used for research. Study coauthor Gizem Gumuskaya experimented with the chemical composition of the tracheal cells' growth conditions and found a way to encourage the cilia to face outward on the organoids. Once she had found the right matrix, the organoids became mobile after a few days, with the cilia acting a bit like oars...

"In our method, each anthrobot grows from a single cell." It's this self-assembly that makes them unique. Biological robots have been made by other scientists, but they were constructed by hand by making a mold and seeding cells to live on top of it, said study author Michael Levin... They survived up to 60 days in laboratory conditions.

The experiments outlined in this latest study are at an early stage, but the goal is to find out whether the anthrobots could have medical applications, Levin and Gumuskaya said. To see whether such applications might be possible, researchers examined whether the anthrobots were able to move over human neurons grown in a lab dish that had been "scratched" to mimic damage. They were surprised to see the anthrobots encouraged growth to the damaged region of the neurons, although the researchers don't yet understand the healing mechanism, the study noted.

Earth

Why Mexico Wants You to Virtually Adopt an Axolotl Salamander (msn.com) 25

It can regenerate bits of its body. Ancient Mexicans revered it as a mischievous, shape-shifting god.

They named it axolotl — translation: "water monster" — and it's a "salamander with a Mona Lisa smile," reports the Washington Post, "an alien-looking creature with a permanent grin and a crown of feathery gills". But while there's over a million in the world's scientific laboratories, back in its only natural habitat — the canals of Lake Xochimilco in Mexico City — it's on the brink of extinction. In hopes of preventing the annihilation of a species with mystifying traits, ecologists at Mexico's National Autonomous University are giving the public the chance to virtually adopt an axolotl. For $30, $180 or $360, donors can choose the sex, age and name of the little buddy they get to call theirs for a month, six months or a year, respectively. The axolotls stay in Mexico, but donors receive an adoption kit with an infographic, the axolotl's identification card, a certificate of adoption and a personalized thank-you letter.

The campaign also includes options to buy an axolotl a meal for $10 or to fix up one of their homes for $50. And for those wanting to splurge a bit more, participants can adopt the axolotl's refuge of chinampas — the artificial islands that dot Lake Xochimilco — for one, six or 12 months starting at $450. The funds will go toward building refuges for the axolotl and restoring its habitat, which has been devastated by the effects of Mexico City's urbanization over the last decades, said Luis Zambrano, an ecologist at Mexico's National Autonomous University.

"A species can't be a species without its habitat," Zambrano said.

Axolotls have "helped scientists understand how organs develop in vertebrates, uncover the causes of the birth defect spina bifida and discover thyroid hormones..."

"The salamanders have also become beloved exotic pets — to the point that 'there's claw machines in Japan that let you pick up an axolotl to take home,' Zambrano added."
Space

Amazon Taps SpaceX For Kuiper Launch (cnn.com) 12

An anonymous reader writes: Amazon just inked a deal with chief competitor and Elon Musk-helmed SpaceX to launch internet-beaming satellites -- a move that comes even as Amazon founder Jeff Bezos pursues his own space dreams with his own rocket company, Blue Origin, and as SpaceX builds its own internet constellation.

While Musk and Bezos have notoriously been publicly competitive and have a history of openly sparring on social media, with Musk regularly making crude jokes about Bezos and Blue Origin, it is not uncommon for business rivals to team up in the world of rocket launches. Some Amazon satellites will still ride on a large rocket made by Blue Origin, dubbed the New Glenn. But it's been delayed for years and will make its launch debut next year at the earliest.

The Military

Pentagon Scientists Discuss Cybernetic 'Super Soldiers' (vice.com) 98

An anonymous reader quotes a report from Motherboard: On Wednesday, a group of military and military-adjacent scientists gathered at a conference to discuss the possibility of creating a super soldier. They discussed breeding programs, Marvel movies, The Matrix, and the various technologies the Pentagon is researching with the goal of creating a real life super soldier complete with cybernetic implants and thorny ethical issues surrounding bodily autonomy. The talk happened at the The Interservice/Industry Training, Simulation and Education Conference, or I/ITSEC, an annual conference where military leaders come to talk shop and simulation corporations gather to demo new products. It's the kind of place where execs and generals don virtual reality helmets and talk about the virtues of VR sims. You could even catch members of congress talking about the importance of simulations and war. "Winning the war of cognition by pushing readiness and lethality boundaries," reads the official poster for the 2019 I/ITSEC.

It was here, in Orlando, Florida, where five illustrious members of the military-industrial complex gathered to discuss super soldiers at the "Black Swan -- Dawn of the Super Soldier" panel. Lauren Reinerman-Jones, an analyst from Defense Acquisition University, moderated a panel that included U.S. Army Developmental Command representatives George Matook and Irwin Hudson, research scientist J.J. Walcutt, and Richard McKinley, who works on "non-invasive brain stimulation" for the Air Force. I/TSEC advertised the panel in its program with a picture of the experts next to a posing Master Chief, the genetically enhanced super soldier from the Halo video game franchise. Throughout the conversation, which covered the nuts and bolts of what's possible now and what's about to be possible along with various ethical concerns, references to science fiction and fantasy stories were common.
Some of the ideas discussed include synthetic blood, pain-numbing stimulants, limb regeneration, and non-invasive brain stimulation. The discussion references the John Scalzi book about a near future where Earth wages war by offering the elderly new youthful bodies in exchange for military service.

They also discuss the ethical and legal concerns surrounding the creation of super soldiers, as well as the societal norms and potential risks. "What risks are we willing to take? There's all these wonderful things we can do," Matook said. "We don't want a fair fight. We really don't, this is not an honorable thing. We want our guys to be over-matching any possible enemies, right? So why aren't we giving them pharmaceutical enhancements? Why are we making them run all week when we could just be giving them steroids? There's all these other things you could do if you change societal norms and ethics. And laws, in some cases."

The discussion concludes with considerations about the long-term effects, reversibility of enhancements, and the potential ownership of enhanced individuals by the government. "So if you do these kinds of changes to an individual, what do you do when their service is up? What happens? Or are they just literally owned by the government for life," asks Reinerman-Jones. Hudson replied with a grim joke: "Termination."
Space

A Strong Solar Storm Is Inbound With a Full Halo CME (space.com) 46

The Space Weather Prediction Center is closely watching the arrival of a super-hot plasma eruption, known as a coronal mass ejection (CME), that will slam into Earth tonight, writes longtime Slashdot reader StyleChief. Images of the huge sunspot "rotating to face the earth" can be viewed here. The Space Weather Prediction Center reports: With 3 CMEs already inbound, the addition of a 4th, full halo CME has prompted SWPC forecasters to upgrade the G2 Watch on 01 Dec to a G3 Watch. This faster-moving halo CME is progged to merge with 2 of the 3 upstream CMEs, all arriving at Earth on 01 Dec. G3 (Strong) conditions are now likely on 01 Dec. Continue to monitor spaceweather.gov for the latest updates. "The rapid Earth-bound CME left the sun on Nov. 29 during a powerful M9.8-class solar flare eruption," reports Space.com. "But it isn't alone."

"The speedy plasma outburst will merge with several slower upstream CMEs that left the sun a day earlier (Nov. 28), creating a 'Cannibal CME' that will likely trigger a strong geomagnetic storm akin to a Nov. 5 event that supercharged auroras and STEVE around the world."
Science

Brain Study Suggests Traumatic Memories Are Processed as Present Experience (nytimes.com) 10

Traumatic memories had their own neural mechanism, brain scans showed, which may help explain their vivid and intrusive nature. From a report: At the root of post-traumatic stress disorder, or PTSD, is a memory that cannot be controlled. It may intrude on everyday activity, thrusting a person into the middle of a horrifying event, or surface as night terrors or flashbacks. Decades of treatment of military veterans and sexual assault survivors have left little doubt that traumatic memories function differently from other memories. A group of researchers at Yale University and the Icahn School of Medicine at Mount Sinai set out to find empirical evidence of those differences.

The team conducted brain scans of 28 people with PTSD while they listened to recorded narrations of their own memories. Some of the recorded memories were neutral, some were simply "sad," and some were traumatic. The brain scans found clear differences, the researchers reported in a paper published on Thursday in the journal Nature Neuroscience. The people listening to the sad memories, which often involved the death of a family member, showed consistently high engagement of the hippocampus, part of the brain that organizes and contextualizes memories. When the same people listened to their traumatic memories -- of sexual assaults, fires, school shootings and terrorist attacks -- the hippocampus was not involved.

[...] Indeed, the authors conclude in the paper, "traumatic memories are not experienced as memories as such," but as "fragments of prior events, subjugating the present moment." The traumatic memories appeared to engage a different area of the brain -- the posterior cingulate cortex, or P.C.C., which is usually involved in internally directed thought, like introspection or daydreaming. The more severe the person's PTSD symptoms were, the more activity appeared in the P.C.C. What is striking about this finding is that the P.C.C. is not known as a memory region, but one that is engaged with "processing of internal experience," Dr. Schiller said.

Space

A Star With Six Planets That Orbit Perfectly in Sync (nytimes.com) 30

Astronomers have discovered six planets orbiting a bright star in perfect resonance. The star system, 100 light-years from Earth, was described on Wednesday in a paper published in the journal Nature. From a report: The discovery of the system could give astronomers a unique opportunity to trace the evolution of these worlds to when they first formed, and potentially offer insights into how our solar system got to be the way it is today. "It's like looking at a fossil," said Rafael Luque, an astronomer at the University of Chicago who led the study. "The orbits of the planets today are the same as they were a billion years ago."

Researchers think that when planets first form, their orbits around a star are in sync. That is, the time it takes for one planet to waltz around its host star might be the same amount of time it takes for a second planet to circle exactly twice, or exactly three times. Systems that line up like this are known as orbital resonances. But, despite the theory, finding resonances in the Milky Way is rare. Only 1 percent of planetary systems still preserve this symmetry.

Most of the time, planetary orbits get knocked out of sync by an event that upsets the gravitational balance of the system. That could be a close encounter with another star, the formation of a massive planet like Jupiter, or a giant impact from space on one planet that causes a ripple effect in other orbits. When this happens, Dr. Luque said, planetary orbits become too chaotic to mathematically describe, and knowledge of their evolution is indecipherable. Astronomers are lucky to find even one pair of exoplanets in resonance. But in the newly discovered star system, there are a whopping five pairs, because all six planets have orbits that are in sync with one another. Dr. Luque described it as "the 1 percent of the 1 percent."

United Kingdom

Genetic Data On 500,000 Volunteers In UK To Be Released For Scientific Study (theguardian.com) 18

An anonymous reader quotes a report from The Guardian: A new era of medical discoveries, treatments and cures is on the horizon, researchers say, following the announcement that an unprecedented trove of genetic information is to be made available to scientists. Health researchers from around the world can now apply to study the whole genomes of half a million people enrolled in UK Biobank, a biomedical research project that has compiled detailed health and lifestyle records on individuals since it began 20 years ago. The move on Thursday amounts to the largest number of whole-genome sequences ever released for medical research. The sequences will be used with UK Biobank's records and other data to delve deeply into the genetics of everything -- from people's risk of obesity, diabetes, heart disease, cancer and other conditions, to individuals' sleep and exercise patterns.

Researchers believe the new data will allow them to calculate people's individual risk scores for a raft of cancers and other diseases, and so work out who could benefit most from early screening. They should also gain a deeper understanding of serious genetic conditions such as Huntington's and motor neurone disease, which have often been studied in small numbers of severely affected patients. Health experts from academia, the government, industry and charities can apply for access though they have to be approved and study the genomes through a protected database stripped of identifying details such as names, addresses, birth dates, and GP information.
"Until 2021 scientists could study only about 1% of the DNA of UK Biobank volunteers -- the fraction that encodes proteins," notes the report. "Since then, whole genomes have been released for 200,000 participants, but work continued to sequence all of the 500,000 volunteers."

"With that number of whole genomes in hand, researchers will be able to find much rarer genes which drive diseases, including those that behave like switches and turn other genes on and off."
Science

Nikola Tesla's Historic Wardenclyffe Lab Site At Risk After Devastating Fire (arstechnica.com) 22

Jennifer Ouellette reports via Ars Technica: Back in 2012, a crowdfunding effort on Indigogo successfully raised the funds necessary to purchase the Wardenclyffe Tower site on Long Island, New York, where Serbian inventor Nikola Tesla once tried to build an ambitious wireless transmission station. The goal was to raise additional funds to build a $20 million Tesla Science Center there, with a museum, an educational center, and a technological innovation program. The nonprofit group behind the project finally broke ground this April after years of basic restoration work -- only to experience a devastating setback last week, two days before Thanksgiving, when a fire broke out.

Over 100 firefighters from 17 local departments responded and battled the flames throughout the night, as residual embers led to two additional outbreaks. One firefighter sustained bruised ribs after falling off a ladder, but there were no other injuries or fatalities. Once the blaze was extinguished, the TSC group called in their engineers to assess the damage and make recommendations for repairs. While an investigation is ongoing as to the cause of the fire, Fire Chief Sean McCarrick said during a press conference on Tuesday, November 28, that they had ruled out arson. According to project architect Mark Thaler, there was nothing flammable in the lab that could have caused the fire, although the back buildings had wood-frame roofs. The original brick building, designed by Stanford White, is still standing, although there is considerable damage to the structure of the roof, steel girders, chimney, cupola, and a portion of a wall. Some elements have been irreparably destroyed, but fortunately all museum artifacts in TSC's collection were stored offsite. The most pressing concern is that water from the firehoses saturated the brick walls, according to Thaler, since the upcoming colder winter temperatures could freeze that moisture and cause the brick work to break apart and collapse. The engineers have also recommended adding strategic wall supports to both the interior and exterior to shore up the structure.

All of this comes with a hefty price tag: $3 million for immediate remediation to seal the roof and dry the building in order to stave off further damage. The building was insured, but that insurance won't come close to covering the cost. The TSC group has set up a 60-day Indiegogo campaign to raise those funds, which is separate from the $14 million it had already raised toward their targeted $20 million goal. "The best way to help right now is to donate if you can," said TSC Executive Director Marc Alessi. "We've never needed it more. We need to secure this lab, stop the water intrusion and future damage. And then we need to complete this project." [...]
"Buildings burn down and can then be rebuilt," said John Gaiman, deputy county executive for Suffolk County. "The ideas behind them, the person, the history, the narrative that was created over 100 years ago still exists, and that will continue."
China

'Global Science is Splintering Into Two - And This is Becoming a Problem' 168

The United States and China are pursuing parallel scientific tracks. To solve crises on multiple fronts, the two roads need to become one, Nature's editorial board wrote Wednesday. From the post: It's no secret that research collaborations between China and the United States -- among other Western countries -- are on a downward trajectory. Early indicators of a possible downturn have been confirmed by more sources. A report from Japan's Ministry of Education, Culture, Sports, Science and Technology, published in August, for instance, stated that the number of research articles co-authored by scientists in the two countries had fallen in 2021, the first annual drop since 1993. Meanwhile, data from Nature Index show that China-based scientists' propensity to collaborate internationally has been waning, when looking at the authorship of papers in the Index's natural-science journals.

Nature reported last month that China's decoupling from the countries loosely described as the West mirrors its strengthening of science links with low- and middle-income countries (LMICs), as part of its Belt and Road Initiative. There are many good reasons for China to be boosting science in LMICs, which could sorely do with greater research funding and capacity building. But this is also creating parallel scientific systems -- one centred on North America and Europe, and the other on China. The biggest challenges faced by humanity, from combating climate change to ending poverty, are embodied in a globally agreed set of targets, the United Nations Sustainable Development Goals (SDGs).

Approaching them without shared knowledge can only slow down progress by creating competing systems for advancing and implementing solutions. It's a scenario that the research community must be more aware of and work to avoid. Nature Index offers some reasons as to why collaboration between China and the West is declining. Travel restrictions during the COVID-19 pandemic took their toll, limiting collaborations and barring new ones from being forged. Geopolitical tensions have led many Western governments to restrict their research partnerships with China, on national-security grounds, and vice versa.
The Internet

Internet Use Does Not Appear To Harm Mental Health, Oxford Study Finds (ft.com) 80

A study of more than 2 million people's internet use found no "smoking gun" for widespread harm to mental health from online activities such as browsing social media and gaming, despite widely claimed concerns that mobile apps can cause depression and anxiety. From a report: Researchers at the Oxford Internet Institute, who said their study was the largest of its kind, said they found no evidence to support "popular ideas that certain groups are more at risk" from the technology. However, Andrew Przybylski, professor at the institute -- part of the University of Oxford -- said that the data necessary to establish a causal connection was "absent" without more co-operation from tech companies. If apps do harm mental health, only the companies that build them have the user data that could prove it, he said.

"The best data we have available suggests that there is not a global link between these factors," said Przybylski, who carried out the study with Matti Vuorre, a professor at Tilburg University. Because the "stakes are so high" if online activity really did lead to mental health problems, any regulation aimed at addressing it should be based on much more "conclusive" evidence, he added. "Global Well-Being and Mental Health in the Internet Age" was published in the journal Clinical Psychological Science on Tuesday.
In their paper, Przybylski and Vuorre studied data on psychological wellbeing from 2.4 million people aged 15 to 89 in 168 countries between 2005 and 2022, which they contrasted with industry data about growth in internet subscriptions over that time, as well as tracking associations between mental health and internet adoption in 202 countries from 2000-19.

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