RadioShack's former CEO tells Canada's National Post newspaper the surprising story of what happened after he left the company in 2004: When it came, rather than being crestfallen, he felt liberated, and free to pursue an "itch" that he had always felt the need to scratch. So he applied to medical school at McMaster University in Hamilton, Ontario... "I don't miss being a CEO one bit," Levy says. "I enjoyed it immensely, when I was doing it. But do I enjoy what I am doing now? The answer is, immensely."

Brian Levy, MD, was talking about his unusual career path with a reporter, via a socially-distanced phone call, on an April afternoon after wrapping up an overnight shift in the Emergency Department at Brampton Civic Hospital, northwest of Toronto. Brampton Civic is among the busiest emergency departments in Canada. The former CEO initially fancied becoming a psychiatrist, given all his years managing people, but he realized early on in medical school that he was more of a generalist, not to mention a Type-A, adrenaline-junky.

"Emergency medicine is a perfect fit for my personality," he says.
The article notes Levy's department "is eerily quiet, preparing for an expected surge in COVID-19 cases" -- and that in his spare time he's still an electronics geek.

"I am just one of those people who was very fortunate, where things worked out, and where I could do not just do one thing I really enjoyed in life, but two."

The New York Post reports that a COVID-19 vaccine "may be six months away, according to a researcher leading a team of scientists in England." "I think there's a high chance that it will work based on other things that we have done with this type of vaccine," Sarah Gilbert, a professor of virology at Oxford told The Times of London. "It's not just a hunch and as every week goes by we have more data to look at. I would go for 80 percent, that's my personal view."
Gilbert added that if they can find places that haven't imposed a lockdown, "we will get our efficacy results very quickly."

America and Israel have also reported encouraging progress on a vaccine. And in the Netherlands and Australia, researchers are testing the effectiveness of the BCG tuberculosis vaccine developed in the 1920s (with more tests being scheduled for Africa, and experiments in the U.K.) UPI reports researchers in the Netherlands "have started recruiting 1,000 healthcare workers, who are at high risk for COVID-19, in eight hospitals who will receive either the BCG vaccine or a placebo."

The Times of London reports that the U.K. government "signalled that it would be willing to fund the manufacture of millions of doses in advance" if the results of professor Gilbert's research looked promising. "This would allow it to be available immediately to the public if it were proven to work.

"With ministers struggling to find a strategy to exit the lockdown, long-term hopes of a return to normality rely on a vaccine."

hackingbear writes: After testing blood from 500 residents for antibodies to the COVID-19 virus in the town of Gangelt, which is a hot spot of the pandemic in Germany, scientists at a nearby university say they have determined that 14% have been infected and are therefore "immune." Some of those people would have had no symptoms at all. Scientists found that 2% of residents were actively infected by the coronavirus and a total of 14% had antibodies, indicating a prior infection. "From the result of their blood survey, the German team estimated the death rate in the municipality at 0.37% overall, a figure significantly lower than what's shown on a dashboard maintained by Johns Hopkins, where the death rate in Germany among reported cases is 2%," reports MIT Technology Review. In contrast, the 2019-2020 seasonal flu has infected up to 17% of U.S. population and killed ~0.1% of those infected. Since first emerged in late December, or purportedly as early as late November, the COVID-19 has infected over 1.6 million people and killed over 100,000.

wiredmikey writes from a report via SecurityWeek: Authorities in Italy are using Drones equipped with heat sensors to take the temperature of citizens and send the information to a drone operator, who has a thermal map on his hand-held screen -- shining orange and purple blobs. The hovering drone emits a mechanical buzz reminiscent of a wasp and shouts down instructions in a tinny voice. "Attention! You are in a prohibited area. Get out immediately," commands the drone, about the size of a loaf of bread. "Violations of the regulations result in administrative and criminal penalties," the drone says. "Once a person's temperature is read by the drone, you must still stop that person and measure their temperature with a normal thermometer," Matteo Copia, a police commander, said. Copia says the local police force has received new powers that allow it to check people's temperature without their knowledge or permission.

The number of deaths linked to the coronavirus worldwide has passed 100,000 as known infections surged past 1.6 million, according to data collected by The New York Times. From a report: At least 177 countries have reported cases. The most recent was war-torn Yemen, which reported its first coronavirus case on Friday. The death toll in the United States has surpassed that of Spain, with almost 18,000 fatalities related to the virus reported by Friday afternoon. Only Italy has reported more deaths. Although some governments are considering easing restrictions, lockdowns are being extended across much of the world heading into the Easter weekend, and policing measures stepped up. Tokyo's governor parted ways with Japan's national government by requesting the closure of a range of businesses -- including nightclubs, karaoke bars, gyms and movie theaters -- during a state of emergency declared this week.

Engineering teams at Apple and Google have banded together to create a decentralized contact tracing tool that will help individuals determine whether they have been exposed to someone with COVID-19. From a report: Contact tracing is a useful tool that helps public health authorities track the spread of the disease and inform the potentially exposed so that they can get tested. It does this by identifying and 'following up with' people who have come into contact with a COVID-19 affected person. The first phase of the project is an API that public health agencies can integrate into their own apps. The next phase is a system level contact tracing system that will work across iOS and Android devices on an opt-in basis. The system uses on-board radios on your device to transmit an anonymous ID over short ranges -- using Bluetooth beaconing. Servers relay your last 14 days of rotating IDs to other devices which search for a match. A match is determined based on a threshold of time spent and distance maintained between two devices.

An anonymous reader quotes a report from Motherboard: A global group of scientists and lawyers announced their efforts to make their intellectual property free for use by others working on coronavirus pandemic relief efforts -- and urged others to do the same -- as part of the "Open Covid Pledge." Mozilla, Creative Commons, and Intel are among the founding members of this effort; Intel contributed to the pledge by opening up its portfolio of over 72,000 patents, according to a press release. Participants are asked to publicly take the pledge by announcing it on their own websites and issuing a press release.

"Immediate action is required to halt the COVID-19 Pandemic and treat those it has affected," the pledge states. "It is a practical and moral imperative that every tool we have at our disposal be applied to develop and deploy technologies on a massive scale without impediment. We therefore pledge to make our intellectual property available free of charge for use in ending the COVID-19 pandemic and minimizing the impact of the disease." From there, people and companies are asked to adopt a license detailing the terms and conditions their intellectual property will be available; while pledgers are permitted to write their own license based on their needs, the organizers wrote "Open COVID License 1.0" as a template for immediate use, which grants usage rights to anyone working toward "minimizing the impact of the disease, including without limitation the diagnosis, prevention, containment, and treatment of the COVID-19 Pandemic." The license is effective until one year after the World Health Organization declares the pandemic to be over. Other participants include Berkeley and UCSF's Innovative Genomics Institute, Fabricatorz Foundation, and United Patents.

jmcbain writes: In many societies, handshakes are a gesture of friendliness. How many times have you shaken hands when meeting new engineering professionals? Probably quite a lot. However, given what we've seen with the SARS-CoV-2 coronavirus, it's time for a new way to greet people. According to a CNBC article, Anthony Fauci, the head advisor of the USA's task force on the coronavirus, says "I don't think we should ever shake hands ever again, to be honest with you. Not only would it be good to prevent coronavirus disease, it probably would decrease instances of influenza dramatically in this country." Other scientists agree with Fauci. Gregory Poland, director of the Mayo Clinic Vaccine Research Group has been trying to put an end to handshakes for nearly three decades. He suggests tilting or bowing your head to greet another person like people did many decades ago. "When men greeted other people [back in the day], they raised tor tipped their hat," he says. Bruce Farber, chief of infectious diseases at Northwell Health in New York, thinks Americans need to start implementing other ways to great each other "like [with] a head bob or wave of a hand. This act would maintain proper distance, avoid contact and potential spread of COVID-19," Farber says.

Peter Pitts, former FDA associate commissioner, says shaking hands transmits germs and viruses "as swiftly as kissing and hugging" and until we develop a vaccine against COVID-19, the new normal will have to be "verbal greetings and long-sleeved elbow bumps." He adds: "The social theme song for right now is 'I wanna, but better not, hold your hand.' Love doesn't conquer all."

Foxconn's Wisconsin plant, the controversial recipient of billions of dollars in tax subsidies and the focus of several investigations, will produce ventilators with medical device firm Medtronic. From a report: The partnership was announced by Medtronic CEO Omar Ishrak in an interview with CNBC, who said that Foxconn will be manufacturing ventilators based on its PB-560 design in the next four to six weeks. Foxconn's Wisconsin plant was first announced way back in 2017 as a $10 billion LCD factory. It was labeled the "eighth wonder of the world" by President Trump, but Foxconn's plans for the site appear to have changed repeatedly over the years. At various points, Foxconn has said that it would build a smaller LCD factory, no factory at all, or that it would produce other items like a robot coffee kiosk. Now, it appears the factory will, in part at least, produce ventilators, after its planned opening next month.

Tekla Perry writes: In 2001, a rapid, easy-to-use, PCR-based testing system for biological testing was still in prototype form when letters containing anthrax spores started arriving in the mailboxes of journalists and senators. Its creators at startup Cepheid quickly adapted it to test for anthrax, and now it is used to run that test as part of U.S. mail sorting systems. The tool, now called GeneXpert, is also installed in health care facilities around the world. And cartridges to allow these systems to test for COVID-19 -- the first rapid such test approved in the U.S. -- are rolling out. The technology relies on microfluidics, and takes about 45 minutes to run an extremely accurate and sensitive test. Cepheid co-founder Kurt Petersen, now an angel investor, explains how it works. "The test cartridge contains microfluidic channels; these are made out of plastic using high-precision injection molding," explains Petersen. "All the chemicals needed for the process are stored in chambers within the system. In the center of the cartridge, a rotary valve turns to open different pathways, while a tiny plunger -- like a syringe -- moves fluids in and out as needed.

So, the plunger pulls the sample into the center, the valve rotates, and the plunger pushes it into another region of the cartridge to do an operation on it. The system can do that multiple times, moving the sample to different regions with different chemicals, extracting RNA, mixing it with the reverse transcriptase that synthesizes complementary DNA that matches the RNA, and eventually pushing it into PCR reaction tube, where rapid heating and cooling speeds up the process of copying the DNA. Each new copy of the DNA gets a fluorescent molecule attached, which allows an optical system to determine whether or not the targeted gene sequence is in the sample."

Deep learning algorithms can diagnose, triage, and monitor coronavirus cases from lung images. Next, can they predict who will need a ventilator? From a report: AI-powered analysis of chest scans has the potential to alleviate the growing burden on radiologists, who must review and prioritize a rising number of patient chest scans each day, experts say. And in the future, the technology might help predict which patients are most likely to need a ventilator or medication, and which can be sent home. "That's the brass ring," says Matthew Lungren, a pediatric radiologist at Stanford University Medical Center and co-director of the Stanford Center for Artificial Intelligence in Medicine and Imaging. "That would be the killer app for this." Some companies are selling their tools, others have released free online versions, and various groups are organizing large crowdsourced repositories of medical images to generate new algorithms. "The system we designed can process huge amounts of CT scans per day," says Hayit Greenspan, a professor at Tel-Aviv University and chief scientist of RADLogics, a healthcare software company that recently announced one such AI-based system. "The capability for quickly covering a huge population is there."

What better way to celebrate World Health Day than by threatening to withhold funding for the World Health Organization. That's exactly what President Trump said he was considering today at Tuesday's coronavirus press briefing. The New York Times reports: "We're going to put a hold on money spent to the W.H.O.; we're going to put a very powerful hold on it and we're going to see," Mr. Trump said, accusing the organization of having not been aggressive enough in confronting the dangers from the virus. "They called it wrong. They call it wrong. They really they missed the call." Mr. Trump appeared to be particularly angry at the W.H.O. for issuing a statement saying it did not support his decision on Jan. 31 to restrict some travel from China because of the virus. At the time, the group issued a statement saying that "restricting the movement of people and goods during public health emergencies is ineffective in most situations and may divert resources from other interventions."

"Don't close your borders to China, don't do this," Mr. Trump said, paraphrasing the group and accusing the organization of "not seeing" the outbreak when it started in Wuhan, China. "They didn't see it, how do you not see it? They didn't see it. They didn't report it. If they did see it, they must have seen it, but they didn't report." In fact, the W.H.O. repeatedly issued statements about the emergence of the virus in China and its movement around the world. The budget for the W.H.O. is about $5 billion and comes from member countries around the world. "In 2017, the last year for which figures were available, the United States was required to spend $111 million based on the organization's rules, but sent an additional $401 million in voluntary contributions," reports The New York Times.

Trump said his government will investigate the organization and that "we will look at ending funding." It's unclear if he's planning to eliminate all funding, or only some.

Coronavirus patients in areas that had high levels of air pollution before the pandemic are more likely to die from the infection than patients in cleaner parts of the country, according to a new nationwide study that offers the first clear link between long-term exposure to pollution and Covid-19 death rates. From a report: In an analysis of 3,080 counties in the United States, researchers at the Harvard University T.H. Chan School of Public Health found that higher levels of the tiny, dangerous particles in air known as PM 2.5 were associated with higher death rates from the disease. For weeks, public health officials have surmised a link between dirty air and death or serious illness from Covid-19, which is caused by the coronavirus. The Harvard analysis is the first nationwide study to show a statistical link, revealing a "large overlap" between Covid-19 deaths and other diseases associated with long-term exposure to fine particulate matter. "The results of this paper suggest that long-term exposure to air pollution increases vulnerability to experiencing the most severe Covid-19 outcomes," the authors wrote.

Autonomous shuttles are being used to move COVID-19 tests from a Jacksonville, Florida testing site to a nearby Mayo Clinic processing location, in what the medical nonprofit is calling a "first" for the U.S. But as is often the case with autonomous vehicle pilot programs, there's a catch: during each run made to and from the clinic, the self-driving shuttles are being trailed by an SUV driven by a human. The Verge reports: The SUV can be spotted in a video released by the Mayo Clinic, after one of the Mayo Clinic workers loads the cooler of tests onto the self-driving shuttle. The SUV then follows the shuttle across the Mayo Clinic's campus, where the batch of fresh tests is swapped for another cooler. Four of these vehicles have made the same run back and forth each day since March 30th. In a statement provided to The Verge, Joe Moye, the CEO of autonomous vehicle operator Beep, said the Jacksonville Transportation Authority is providing the chase vehicles to "ensure no traffic or pedestrians would potentially impact the delivery path of the COVID-19 samples and supplies." That's despite the fact that the Mayo Clinic's press release says the routes the shuttles are running "are isolated from pedestrians, traffic and staff."

A representative for Beep, which worked with the Mayo Clinic, JTA, and self-driving shuttle builder Navya on the pilot, says that putting the tests in the attendant-less shuttle instead of in an SUV or truck being driven by a human helps limit any potential exposure to the novel coronavirus. And judging from the distance covered in the video released by the Mayo Clinic, it does look like using some sort of vehicle -- autonomous or not -- would indeed help speed up the delivery of the tests to the processing site. Another benefit, according to Moye, is that the shuttle helps keep many Mayo Clinic staff as free as possible, since they would otherwise have to transport the samples themselves.

Boris Johnson has been taken into the hospital intensive care unit for treatment for coronavirus after his condition worsened, his office said. The Guardian reports: The British prime minister was admitted to St Thomas's Hospital in London on Sunday night because his virus symptoms had not cleared up and he became more seriously ill on Monday afternoon, a government spokesperson said in an email. "Over the course of this afternoon, the condition of the prime minister has worsened and, on the advice of his medical team, he has been moved to the intensive care unit at the hospital," according to the statement. Foreign Secretary Dominic Raab will stand in for Johnson running the country, "where necessary." Mr. Johnson was confirmed to have coronavirus last Thursday, becoming the first Western leader known to have contracted the disease. On Sunday evening, Johnson was admitted to the hospital as a "precautionary step," according to his Downing Street Office.

An experimental program led by Google parent Alphabet to wipe out disease-causing mosquitoes succeeded in nearly eliminating them from three test sites in California's Central Valley. From a report: Stamping out illness caused by mosquitoes is one of Alphabet unit Verily's most ambitious public-health projects. The effort appears to be paying off, according to a paper published in the journal Nature Biotechnology on Monday. Verily is also running coronavirus triage and testing in parts of California. Bradley White, the lead scientist on the Debug initiative, said mosquito-suppression is even more important during the pandemic, so that outbreaks of mosquito-borne diseases such as dengue fever don't further overwhelm hospitals.

Since 2017, the company has released millions of lab-bred Aedes aegypti male mosquitoes into several Fresno County neighborhoods during mosquito season. The insects are bred in Verily labs to be infected with a common bacterium called Wolbachia. When these male mosquitoes mate with females in the wild, the offspring never hatch. In results of the trial published on Monday, Verily revealed that throughout the peak of the 2018 mosquito season, from July to October, Wolbachia-infected males successfully suppressed more than 93% of the female mosquito population at field test sites. Only female mosquitoes typically bite.

Microsoft co-founder Bill Gates said his foundation will spend billions of dollars to fund the construction of factories for the most promising efforts to develop a vaccine to combat the novel coronavirus. From a report: Mr. Gates, a billionaire philanthropist who is one the richest people in the world, said the Bill and Melinda Gates Foundation will work with seven makers of a possible vaccine to build these factories. Mr. Gates, who announced the efforts in an appearance on "The Daily Show With Trevor Noah" Thursday, acknowledged that billions of dollars would be wasted on vaccines that won't pan out. "Our early money can accelerate things," Mr. Gates said. "Even though we'll end up picking at most two of them, we're going to fund factories for all seven, just so that we don't waste time in serially saying which vaccine works and then building the factory."

"Apple announced Sunday it's launched a companywide effort to design, produce and ship face shields to medical workers battling the coronavirus outbreak," reports CNET: The first shipment was delivered this week to a Kaiser facility in the Santa Clara Valley, Apple CEO Tim Cook said in a video posted to Twitter.

"Teams across Apple have been working hard on ways we can support our heroic front-line medical professionals," Cook said, explaining that the fully adjustable shields pack flat and can be assembled in two minutes. "The feedback from doctors was very positive." "We plan to ship over 1 million by the end of this week, and over 1 million per week after that," he said. Cook said the company is coordinating with health and government officials across the US to get the shields delivered where they're needed and hopes to expand distribution beyond the US quickly.
"Apple is dedicated to supporting the worldwide response to COVID-19," Apple's CEO said on Twitter. "We've now sourced over 20M masks through our supply chain."

This week, tech pundit Robert Cringely described how a chance conversation with China-based entrepreneur Anina led to a friend with a garment factory "now making fully certified N-95 respirators with no clear distribution plan." Late on a Sunday night with the tech world in shut-down, how long would it take for me to find someone looking for up to five million N-95 masks? It took 10 minutes.

I reached out to Salesforce.com CEO Marc Benioff and to Mark Cuban from the Dallas Mavericks and Shark Tank... Mark Cuban put me in touch with ProjectN95, a just-created national clearinghouse for urgently needed medical equipment... It's important to realize what a miracle we accomplished. Normally there are lots of middlemen in Chinese distribution, but in this case, there were none, which meant maximal speed and minimal price. The goods were U.S. FDA certified, too, and the certification could be verified...

We are tech people attempting to function during a pandemic, but what really counted here were personal relationships. Anina knows and trusts the factory owner. Anina and I have known each other for 15 years and I've known Marc Benioff and Mark Cuban even longer. We spend billions as a culture trying to build digital versions of such webs of trust, but sometimes it is better to do it the old fashion way.

"Crowds flock to Santa Clara County test sites to learn if they have antibodies to COVID-19," reports the Bay Area Newsgroup, citing long lines of cars forming at three Stanford research sites for the drive-through tests: The 2,500 test slots on Friday and Saturday filled up within hours, as news of the project -- the first large scale study of its type in the U.S. -- spread quickly through the county. The test detects protective antibodies to the virus rather than the virus itself. This gives scientists a snapshot of how many people in the county have already been infected, but weren't seriously sick and didn't realize it. And it tells residents whether they carry potentially protective antibodies -- so may be immune to future infection. "This is critical information," said principal investigator Dr. Eran Bendavid, an infectious disease specialist and professor of medicine with Stanford Health Policy.

"We will show the country what to do and how to do it," he said... It can guide public health measures and policies -- showing where the epidemic is heading, when it is safe to lift shelter-in-place restrictions and how far away we are from "herd immunity," when it becomes harder for a virus to spread...

This approach, called a "serological test," remains a research tool and is not yet widely available in the United States. Stanford is working on a second test that will be deployed for more widespread use. U.S. Food and Drug Administration approval is imminent -- "within hours, not days," [California governor] Newsom said.... Meanwhile, a global effort to study antibodies is being coordinated by the World Health Organization. Called Solidarity II, more than a half dozen countries will pool their findings from large-scale testing...

It is not yet proven that these antibodies actually provide protection... But there are promising clues that COVID-19 might act like it's closest cousin, the SARS virus, which triggers an immune response that persists for at least three years. In a Chinese study of rhesus monkeys, COVID-19 antibodies protected the animals from a second infection.

If protected, people could potentially return to work. There is also the prospect that the antibodies could be used as therapy against the disease. Dozens of companies are working to develop antibody tests, as are researchers at the Centers for Disease Control and Prevention.
The article notes that United Biomedical Inc will "soon" also provide free antibody testing to all 8,000 residents in Telluride, Colorado, and in some countries in Asia.