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Medicine

'No Evidence' That Omicron is Less Severe Than Delta, Say Imperial Researchers (reuters.com) 348

There is at present "no evidence" that the Omicron coronavirus variant is any less severe than the Delta strain, according to early findings from researchers at Imperial College London, which also highlighted the elevated risk of reinfection posed by Omicron and the need for booster shots to combat it. From a report: The research, based on UK infection data, casts doubt on the hopes of some experts that a change in the virulence of the new variant would ease the pressure on health systems despite Omicron's high levels of infectiousness. "The study finds no evidence of Omicron having lower severity than Delta, judged by either the proportion of people testing positive who report symptoms, or by the proportion of cases seeking hospital care after infection," said the research team, led by Professor Neil Ferguson, an infectious disease modeller and government science adviser. However, they cautioned that hospitalisation data "remains very limited at this time." The study said data suggested "at most, limited changes in severity compared with Delta." Early reports from medics in South Africa's Gauteng province, the centre of the Omicron outbreak there, had raised hopes that the variant's mutations might have led to a change in the virus' biology causing it to be less severe.
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'No Evidence' That Omicron is Less Severe Than Delta, Say Imperial Researchers

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  • Cuts both ways (Score:5, Insightful)

    by Dictator For Life ( 8829 ) on Friday December 17, 2021 @01:09PM (#62091041) Homepage
    TFA also says there is insufficient data concerning hospitalizations, so, yeah, nothing much to see here.
    • I thought the point was it doesn't cut anyway. Inconclusive.
    • Re: (Score:2, Insightful)

      by Anonymous Coward

      "There is no evidence" is a fucking nothingburger. It asserts nothing. Take a big bite of air and enjoy.

      When you have sufficient data, that IS "evidence that omicron is no less severe than delta", a demonstrated pattern.

      I'm not interested in diving whatever agendas are at play here, because this bullshit goes way further back than that. It's old and I'm sick of it. At best, someone babbling about "there's no evidence" asserts that other assertions should be scrutinized, that we are as yet unsure, agnostic.

      • by Immerman ( 2627577 ) on Friday December 17, 2021 @03:34PM (#62091761)

        >At best, someone babbling about "there's no evidence" asserts that other assertions should be scrutinized, that we are as yet unsure, agnostic. "i dunno lol."

        Exactly

        So long as we don't know, and there are many people claiming we *do* know, it's important that prominent voices speak out saying "We don't know yet". Otherwise by the time we really do know, the masses may already be convinced of a falsehood.

        That's especially dangerous when the (potential) falsehood is "it's less/not dangerous", and thus promotes widespread reckless behavior.

  • by eneville ( 745111 ) on Friday December 17, 2021 @01:10PM (#62091047) Homepage

    Continue wearing a mask, avoid crowds, don't travel, socially distance and wash your hands like it's spring 2020.

    • by olsmeister ( 1488789 ) on Friday December 17, 2021 @01:13PM (#62091059)
      Fuck that. I'm just going to keep up to date on my vaccinations and boosters, and let the chips fall where they may. This has gone on long enough. At some point things need to return to normalcy, one way or another. I have to wonder if all this screwing around is doing nothing but dragging this on and on endlessly, with mutation after wave after mutation.
      • by layabout ( 1576461 ) on Friday December 17, 2021 @01:26PM (#62091143)
        I understand the fatigue factor. I am missing out in so many activities that I would love to engage in but I don't because if I get infected, it's bad. If I infect other people, it's worse because that adds to the public health care load which is currently breaking our medical system.

        I would argue for adding masking with a good N95 mask to your daily life. Omicron is demonstrably more infectious, severity of infection is TBD as is the incidence of long Covid. However it's not just about you. It's good that you're keeping up-to-date in the vaccinations. You are ahead of a huge number of people in this world. Masking is essential to keep from infecting other people should you be unlucky enough to have a breakthrough infection with omicron.

        vaccines, boosters, and masks are what's required to keep other people from getting sick and you getting sick from them.
      • Sorry, but you'll never be normal.

        What people mean when they say this is, "Let me go back to my Wall-E sled!"

        What they don't realize is that they still have their teevee. Nothing changed.

      • by Rei ( 128717 )

        . I have to wonder if all this screwing around is doing nothing but dragging this on and on endlessly,

        The report you're commenting on came to the conclusion that past infection is only 19% protective in this wave. Getting infected before doesn't mean you won't get infected now. Getting infected now doesn't mean you won't get infected later. And each infection is a new chance to create the mutations that set off the next wave. Oh, and FYI: Regeneron basically doesn't work anymore, and Molnupiravir and Pax

      • by gtall ( 79522 )

        Screwing around? What precisely do you think is "screwing around". Mutations will happen, it is what viruses do.

        Also, I've consulted the Cosmic Normalcy Guide, it turns out there is no rule that says Normalcy must return. Yes, I know, it seems odd but there you go.

      • by jellomizer ( 103300 ) on Friday December 17, 2021 @02:45PM (#62091493)

        At this point I just consider having a mask on in public, is like having a jacket, or keeping your shoes on.

        While the vaccinations are extremely effective, you are still at risk, and if you are at risk you could be spreading to other people who may not be vaccinated or can take more risk.

        I don't care if you catch COVID, I don't care if you get better, I don't care if you Die from it. But I do care that you had spread it to perhaps hundreds of other people while you were infectious and didn't have symptoms.

      • I have to wonder if all this screwing around is doing nothing but dragging this on and on endlessly, with mutation after wave after mutation.

        We are where we are because a lot of yokels don't wear masks and don't get vaccinated (plus, it is a global pandemic that generates new mutations as it hits different regions of the world at different times.

        Sure, at some point the world will return to normal. A lot of people who rushed "to normal" ain't around to see how and when things go back to normal. It was understandable in 2020. But in 2021, I don't get it.

        I, for one, will keep getting my vaccines. On top of that, I will just follow the example f

      • You realize "Fuck that" is how we get mutation after mutation, right?

        More people saying "fuck that" -> more people infected -> more opportunities for mutation

    • Dang. I was really hoping to get back to kiss-hellos and my hobby of licking door knobs.

    • Continue wearing a mask, avoid crowds, don't travel, socially distance and wash your hands like it's spring 2020.

      I dunno where you live, but no one around here has been doing any of that since about last April or so?

      I've not really worn a mask since I got my 2nd shot first of April, and no one really wears them...except the occasional elderly person you see out.

      Been to music events, dining out in packed restaurants, gun shows, etc...

      Life here has been back to normal for quite some time now, and all covi

      • I wonder how docile we would have been without TV?

        We have faced more severe restrictions then we did under British rule and not many seem to care.

        I get people being scared but this is destroying communities. I am waiting for the long term effects of children in their formative years not being able to see peoples faces. Having to treat every person - including themselves - as a biohazard. We have done a lot to dehumanize each other all in the name of protecting one another.

        I'm sure someone will be vulger

    • People keep including "wash your hands" as part of the standard COVID mantra. However isn't it pretty well established that surface transmission of COVID is negligible?

      There are certainly other good reasons to wash your hands regularly - but I'm not sure that COVID is one of them.

      • But not too regularly. Otherwise you might have such a weak immune system that you could get sick just from touching things.
      • >"People keep including "wash your hands" as part of the standard COVID mantra. However isn't it pretty well established that surface transmission of COVID is negligible?"

        Same with cloth masks. But whatever. Gotta do "something", especially if it LOOKS like you are doing something.

  • Evolution (Score:2, Insightful)

    by fermion ( 181285 )
    For a virus to thrive it must be infectious but not severe in symptoms to most. COVID should evolve to some that is less symptomatic and less deadly, but more infectious. Dead people are less likely to spread a virus The purpose of the vaccines is to make the virus symptoms less dangerous and to make it less infectious. Of course we are getting all these variants because only some are getting vaccinated. In places like the African continent it is lack of vaccine. In places like the US it is lack of a bas
    • Re:Evolution (Score:4, Insightful)

      by fred6666 ( 4718031 ) on Friday December 17, 2021 @01:20PM (#62091109)

      Except that if the host dies 2 weeks later, it had plenty of time to infect many other people

    • Because the vaccines make variants less likely to kill someone, more deadly variations could survive because they don't kill their hosts.
    • Re:Evolution (Score:4, Insightful)

      by Rei ( 128717 ) on Friday December 17, 2021 @01:48PM (#62091243) Homepage

      The virus doesn't give a rat's arse what happens to you after your primary infectious period, which is before and shortly after symptom onset. You could burst into flames for all it cares after that point. You're a dead-end host.

      • You could burst into flames for all it cares after that point.

        That would be an interesting illness, politically speaking.

    • For a virus to thrive it must be infectious but not severe in symptoms to most

      That's one model.

      Killing the host after enough time has passed to spread to many other hosts is a model that also works.

    • Re:Evolution (Score:5, Insightful)

      by Eravnrekaree ( 467752 ) on Friday December 17, 2021 @04:51PM (#62092103)

      This is a dangerous virus myth and repeatedly has been denounced by experts, Thats because if the virus has a long enough incubation period, it can spread just fine, despite being deadly, if the deadly symptoms start to show up later. With SARS, its often 7 days to hospitalization, and 3 days to symptoms. So there is a lot of time for it to spread. Higher viral loads can increase spread advantage while making the virus worse. What you are saying is only true of the virus has to kill instantly which is not how things work. Many other viruses don't follow the stupid myth like Smallpox, Measles, Polio, Ebola, HIV, Hepatitis, pandemic Flus, etc.

  • by JoeyRox ( 2711699 ) on Friday December 17, 2021 @01:18PM (#62091091)
    "South Africa delivered some positive news on the omicron coronavirus variant on Friday, reporting a much lower rate of hospital admissions and signs that the wave of infections may be peaking. Only 1.7% of identified Covid-19 cases were admitted to hospital in the second week of infections in the fourth wave, compared with 19% in the same week of the third delta-driven wave, South African Health Minister Joe Phaahla said at a press conference. Health officials presented evidence that the strain may be milder, and that infections may already be peaking in the country's most populous province, Gauteng."

    Bloomberg: South Africa Hospitalization Rate Plunges in Omicron Wave [bloomberg.com]
    • by wakeboarder ( 2695839 ) on Friday December 17, 2021 @01:32PM (#62091173)

      Both data from the UK and South Africa show that when compared to the delta wave last summer, deaths are not rising with the case load. This is probably due to a number of factors such as vaccines, antivirals/corona drugs and people that already have a latent immunity.

      • by JoeyRox ( 2711699 ) on Friday December 17, 2021 @01:39PM (#62091199)
        Both data from the UK and South Africa show that when compared to the delta wave last summer, deaths are not rising with the case load. This is probably due to a number of factors such as vaccines, antivirals/corona drugs and people that already have a latent immunity.

        That may be the case in the UK but South Africa has a very low vaccination rate [bbc.com].
        • But they might have a much higher infection base rate from alpha+delta than previously known since ZA have a much younger base population than Western countries, and since younger people mostly get symptom free infections and you only test once you show symptoms...
      • by hey! ( 33014 )

        Right. Politicians and people who take their world view from them are always *instantly* certain about what any event or piece of data signifies, but science takes time and effort to figure things out -- if it ever does. Science also changes its mind, which politically-driven thinkers never do. Politics regards uncertainty as weakness, but science *runs* on the stuff.

        In a nutshell there are reasons to feel optimistic about data coming out of South Africa and the UK, but it's very early days yet.

    • Further proof (Score:4, Informative)

      by SuperKendall ( 25149 ) on Friday December 17, 2021 @01:43PM (#62091217)

      South Africa has a COVID fatality rate 25 times lower [twitter.com] than previous peak.

      That's a chart you can view directly ay the link...

    • by RobinH ( 124750 )
      They did (double dose) vaccinate a lot of people between the Delta and Omicron waves, and a lot of people got Delta there. Even though Omicron seems to be able to get past vaccination and prior infection, that doesn't mean it doesn't offer some protection against severe disease or hospitalization. Indeed, that does seem to be the case.
    • Re: (Score:3, Interesting)

      by thegarbz ( 1787294 )

      No it doesn't. Data from South Africa continues to show that the infection *in South Africa* has largely spread through the school system with Omicron overwhelmingly affecting the young who are largely being ignored by various COVID measures the world over.

      COVID is mild in young people. All COVID. Omicron, Delta, Beta, and whatever Trump called the WuFlu.

      Hint: research involves more than just reading a Bloomberg article. You should really consider letting professionals do their job.

      • No it doesn't. Data from South Africa continues to show that the infection *in South Africa* has largely spread through the school system

        Link please, I've seen soem articles that claim most Omicron is under 40, but not limited to schools at all.

        The very fact Omicron would be limited to younger population would still prove the point of the main poster, that it's less dangerous overall.

        • Some observations suggest to me another hypothesis which doesn't seem to be discussed much:

          Is the increased infectivity of omicron particularly concentrated among younger people for biological, and not just rate and type of social contact, reasons? It does seem from very preliminary data that it's increase is dominating in younger people though at present that could be just the social factors. But what if it isn't?

          That would confound the observation of so far low severity rate.

          If severity in old were sim

      • No it doesn't. Data from South Africa continues to show that the infection *in South Africa* has largely spread through the school system with Omicron overwhelmingly affecting the young who are largely being ignored by various COVID measures the world over.

        Can you please quantify "largely"? That doesn't sound like an actionable statistic to me.

        "Five weeks of data from the administrative capital Pretoria and the surrounding municipality show that hospitalizations are lower across all age groups. Among t
      • No it doesn't. Data from South Africa continues to show that the infection *in South Africa* has largely spread through the school system with Omicron overwhelmingly affecting the young who are largely being ignored by various COVID measures the world over.

        This is factually incorrect. The highest rates are from people in their 30s which is above ZAs median age.

        https://www.nicd.ac.za/wp-cont... [nicd.ac.za]

  • by JoeyRox ( 2711699 ) on Friday December 17, 2021 @01:34PM (#62091179)
    A study led by researchers from the LKS Faculty of Medicine at The University of Hong Kong (HKUMed) provides the first information on how the novel Variant of Concern (VOC) of SARS-CoV-2, the Omicron SARS-CoV-2 infect human respiratory tract....They found that the novel Omicron variant replicates faster than the original SARS-CoV-2 virus and Delta variant in the human bronchus. At 24 hours after infection, the Omicron variant replicated around 70 times higher than the Delta variant and the original SARS-CoV-2 virus. In contrast, the Omicron variant replicated less efficiently (more than 10 times lower) in the human lung tissue than the original SARS-CoV-2 virus, which may suggest lower severity of disease.

    Source: HKUMed finds Omicron SARS-CoV-2 can infect faster and better than Delta in human bronchus but with less severe infection in lung [med.hku.hk]
    • by mbkennel ( 97636 ) on Friday December 17, 2021 @02:48PM (#62091519)

      The the damage to lungs which causes severe hospitalization & death is from complex immune system reactions & destruction, which is why anti-virals only seem to work in the earlier stages of infections, and after hospitalization the treatments are immune suppressants like steroids and IL-6 inhibitors.

      So only if the lower replication of omicron in lung tissues also results in lower immune reactions & destruction to such tissues (possible but not at all guaranteed), would it be safe to assume lower severity of disease.

  • I'm pretty sure it means the data they analyzed doesn't show less severity, which is a completely fair statement to make. The headline seems to imply there's no evidence anywhere, and I don't think that's true. There are some hopeful glimmers including the very recent hospitalization data out of South Africa, and the study saying Omicron reproduces 70 times faster in the airways, but 10 times slower in the lungs... which lines up with the idea that it's more transmissible but *might* be less severe. That
  • They're Imperial Researchers! So they must work directly for Queen Elizabeth - or Emperor Palpatine.

  • The link has nothing to do with the summary provided. The link is to a report on a US study indicating vaccines are less effective against omicron, while the summary is about a report from a UK study about omicron being no less severe.
  • Spend a good part of a century telling people they have best country in the world, that their nationality is "exceptional", that their individual rights are guaranteed and sacrosanct, and that they don't have to flex one inch to grease the social wheels of society if it impedes them in the slightest, and America is what you get.

    Toxic individualism. On the opposite end of toxic collectivism, and nearly as damaging,

    Then when you need them to band together for the good of the group, not only do they lack the w

  • by forgottenusername ( 1495209 ) on Friday December 17, 2021 @02:24PM (#62091379)

    > The study finds no evidence of Omicron having lower severity than Delta, judged by either the proportion of people testing positive who report symptoms, or by the proportion of cases seeking hospital care after infection. However, hospitalisation data remains very limited at this time.

    This is the study people are linking to if you follow the maze long enough; https://www.imperial.ac.uk/mrc... [imperial.ac.uk]

    Relevant bit:

    > Hospitalisation and asymptomatic infection indicators were not significantly associated with Omicron infection, suggesting at most limited changes in severity compared with Delta.

    So you have SA saying it's milder, then you have the rest of the world with "not enough data".

    Premature to be making claims either way. The study was a period less than 2 weeks.

  • by kbahey ( 102895 ) on Friday December 17, 2021 @02:28PM (#62091395) Homepage

    This is Ontario's modelling for omicron [documentcloud.org], which was presented yesterday.

    Note slides 6, 7 and 8, which are titled as follows, with graphs:

    South Africa is cited as evidence of Omicron's lower severity,but hospitalizations, ICU occupancy, and in-hospital deaths are rising despite a younger population with some immunity

    ...

    A steep rise in cases in South Africa during the current Omicron wave is followed by a steep rise in hospitalizations, while the rise in deaths currently is less steep than in previous waves

    And ...

    Initial data from Denmark indicate that the percentage of cases requiring hospital admission is not lower with Omicron

    Also according to South Africa [reuters.com] today, there is an uptick in deaths, mainly in the unvaccinated. Those who are vaccinated or have been infected have a somewhat milder course of the disease.

    And, how many folds does it have to be milder to make up for its extreme spread? The doctor who is the head of the Science Advisory Table for Ontario said virulence has to be reduced by 10X, and that is not biologically possible [youtube.com].

    Besides, South Africa's demographics are skewed towards a younger population, and they are in early summer (so people gather outdoors), you can't extrapolate what happens in industrial countries in northern latitudes (where it is colder, and gathering indoors), and they have an older population.

  • by quenda ( 644621 ) on Saturday December 18, 2021 @05:39AM (#62093535)

    We have all been waiting and hoping for a less severe strain to displace Delta, but many people seem to be missing what is worrying our hospitals.

    This looks like spreading far more quickly than Delta. If we get a years worth of infections in a month, but only half the hospitalisation rate, that is still six times as many ICU beds demanded. We don't have that many. When hospitals are overwhelmed, the fatality rate can be much higher, as well as the number of survivors with permanent heart or lung damage. It might not matter which strain you get, but it does matter if you are one of the unlucky ones that needs hospital care when the system is not coping.

    I'm not saying that will happen, just that medical people are concerned that it might. It is very sad to see the degree of partisan squabbling above. How did this become so party political in the US? I really worry for you guys, and I'm not talking about the virus.

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