CNN reports on researcher Michael Worobey, "who specializes in tracing the genetic evolution of viruses," who has now found "considerable evidence that the virus arose in an animal, and did not start circulating until the end of 2019." One case especially stood out — that of a 41-year-old accountant who allegedly got sick on December 8, 2019 and who had no connection to the market. The case has been cited as evidence the pandemic must not have started at the market.

Worobey found records that showed the man didn't become ill with Covid-19 until later in December and that his December 8 problem was related to his teeth.

"This is corroborated by hospital records and a scientific paper that reports his COVID-19 onset date as 16 December and date of hospitalization as 22 December," Worobey wrote in a commentary in the journal Science. That would make a seafood vendor who worked at the market and who got sick December 11, 2019, the earliest documented case, Worobey said.

Other research helped Worobey come up with a map of the earliest cases that clusters them all around the market. "That so many of the more than 100 COVID-19 cases from December with no identified epidemiologic link to Huanan Market nonetheless lived in its direct vicinity is notable and provides compelling evidence that community transmission started at the market," he wrote. "It tells us that there's a big red flashing arrow pointing at Huanan Market as the most likely place that the pandemic started," Worobey told CNN. "The virus didn't come from some other part of Wuhan and then get to Huanan market. The evidence speaks really quite strongly to the virus starting at the market and then leaking into the neighborhoods around the market...."

The journal Science subjected Worobey's research to outside scrutiny before publishing it.
Interestingly, Science also published a letter in May in which Worobey had joined 17 other scientists to urge the investigation of both the "natural origin" and "lab leak" theories. But now while he still believes the Chinese government should've investigated the lab leak theory, "holy smokes — is there a lot of evidence against it, and in favor of natural origin," Worobey tells CNN. And he's now telling the Los Angeles Times that his new research "takes the lab-leak idea almost completely off the table.... So many of the early cases were tied to this one Home Depot-sized building in a city of 11 million people, when there are thousands of other places where it would be more likely for early cases to be linked to if the virus had not started there."

Or, as he explained his research to the Washington Post, "It becomes almost impossible to explain that pattern if that epidemic didn't start there."

A virologist at Texas A&M University who was one of the coronavirus experts giving SARS-CoV-2 its name called Worobey's research "detailed and compelling," while a virologist at Tulane University also tells the Post the new research "shows beyond a shadow of a doubt that in fact the Huanan market was the epicenter of the outbreak."

"An Australian company is part of an international effort to recycle dangerous space junk into rocket fuel — in space," reports the Guardian.

Slashdot reader votsalo shared their report (which also looks at some of the other companies working on the problem of space debris). South Australian company Neumann Space has developed an "in-space electric propulsion system" that can be used in low Earth orbit to extend the missions of spacecraft, move satellites, or de-orbit them. Now Neumann is working on a plan with three other companies to turn space junk into fuel for that propulsion system... Another U.S. company, Cislunar, is developing a space foundry to melt debris into metal rods. And Neumann Space's propulsion system can use those metal rods as fuel — their system ionises the metal which then creates thrust to move objects around orbit.

Chief executive officer Herve Astier said when Neumann was approached to be part of a supply chain to melt metal in space, he thought it was a futuristic plan, and would not be "as easy as it looks".

"But they got a grant from NASA so we built a prototype and it works," he said...

Astier says it is still futuristic, but now he can see that it's possible. "A lot of people are putting money into debris. Often it's to take it down into the atmosphere and burn it up. But if it's there and you can capture it and reuse it, it makes sense from a business perspective, because you're not shipping it up there," he said.

"It's like developing a gas station in space."

"Although Oumuamua probably isn't some probe looking for humpbacked whales," writes Slashdot reader alaskana98, "it does continue to deliver plenty of intrigue — and controversy — for those astronomy buffs out there.

"In the latest move in the war on who gets to define what exactly OuMuaMua is, Harvard astrophysicists Amir Siraj and Avi Loeb have countered the prevailing hypothesis that it is a frozen chunk of nitrogen with their own — that it is simply not possible."

LiveScience reports: According to Siraj and his co-author, Harvard astrophysicist Avi Loeb, Jackson and Desch's conclusion that 'Oumuamua is a nitrogen iceberg is flawed because there isn't enough nitrogen in the universe to make an object like 'Oumuamua, which is somewhere between 1,300 and 2,600 feet (400 and 800 meters) long and between 115 and 548 feet (35 and 167 m) wide.

Pure nitrogen is rare, Siraj said, and has been found only on Pluto, where it makes up about 0.5% of the total mass. Even if all of the nitrogen ice in the universe was scraped off every Pluto-like planet that's predicted to exist, there still wouldn't be enough nitrogen to make 'Oumuamua.

An anonymous reader quotes a report from Phys.org: NASA and the nation's top federal nuclear research lab on Friday put out a request for proposals for a fission surface power system. NASA is collaborating with the U.S. Department of Energy's Idaho National Laboratory to establish a sun-independent power source for missions to the moon by the end of the decade. If successful in supporting a sustained human presence on the moon, the next objective would be Mars. NASA says fission surface power could provide sustained, abundant power no matter the environmental conditions on the moon or Mars. The reactor would be built on Earth and then sent to the moon.

Submitted plans for the fission surface power system should include a uranium-fueled reactor core, a system to convert the nuclear power into usable energy, a thermal management system to keep the reactor cool, and a distribution system providing no less than 40 kilowatts of continuous electric power for 10 years in the lunar environment. Some other requirements include that it be capable of turning itself off and on without human help, that it be able to operate from the deck of a lunar lander, and that it can be removed from the lander and run on a mobile system and be transported to a different lunar site for operation. Additionally, when launched from Earth to the moon, it should fit inside a 12-foot (4-meter) diameter cylinder that's 18 feet (6 meters) long. It should not weigh more than 13,200 pounds (6,000 kilograms). The proposal requests are for an initial system design and must be submitted by Feb. 19.

Satellite trackers have been working overtime to figure out just how much dangerous debris Russia created when it destroyed one of its own satellites early Monday -- and the picture they've painted looks bleak. Multiple visual simulations of Russia's anti-satellite, or ASAT, test show a widespread cloud of debris that will likely menace other objects in orbit for years. The Verge reports: It's going to take weeks or even months to fully understand just how bad the situation is, but early visualizations of the ASAT test created by satellite trackers show an extensive trail of space debris left in the wake of the breakup. The fragments appear like a dotted snake in orbit, stretching out and moving in roughly the same direction that Kosmos 1408 used to move around Earth. And there's one thing the visualizers agree on: this snake of debris isn't going anywhere anytime soon. "There will be some potential collision risk to most satellites in [low Earth orbit] from the fragmentation of Cosmos 1408 over the next few years to decades," LeoLabs, a private space tracking company in the US, wrote in a blog post.

Two visualizations created by the European Union's Space Surveillance and Tracking (SST) network and space software company AGI reveal what likely happened in the first moment of impact when Russia's missile intercepted Kosmos 1408. They both show how the debris cloud grew instantly and spread throughout space. AGI's simulation also shows just how close the cloud comes to intersecting with the International Space Station, validating NASA's concerns and the agency's decision to have the astronauts shelter in place.

Another visualization created by Hugh Lewis, a professor of engineering at the University of Southampton specializing in space debris, shows just how widely the debris from Kosmos 1408 has spread out in space. Lewis explains that when Russia's missile hit the satellite, each of the fragments that were created got a little kick, sending them to higher and lower altitudes. Each piece is moving at a different speed depending on the height of its orbit. Lewis says that the cloud will continue to morph over time. The debris fragments in the lower orbits will fall to Earth and out of orbit more quickly, while the ones in higher orbits will stay in space much longer.

NASA has now released the most detailed footage yet of Ingenuity in flight. Gizmodo reports: The two videos were taken during the rotorcraft's 13th flight, which took place on September 4. The 16-second flight saw Ingenuity travel nearly 700 feet horizontally, at an altitude of 26 feet. The Perseverance rover recorded the rotorcraft's maneuvers using its two-camera Mastcam-Z, from a distance of about 1,000 feet away.

"The value of Mastcam-Z really shines through with these video clips," Justin Maki, deputy principal investigator for the Mastcam-Z instrument at NASA's Jet Propulsion Laboratory in Southern California, said in a NASA press release. "Even at 300 meters [984 feet] away, we get a magnificent closeup of takeoff and landing through Mastcam-Z's âright eye.' And while the helicopter is little more than a speck in the wide view taken through the 'left eye,' it gives viewers a good feel for the size of the environment that Ingenuity is exploring."

Recently, the scientists at NASA had to program Ingenuity to move a little faster, to compensate for the thinner atmosphere on Mars as the planet's seasons change. The helicopter's navigation system is automated and uses artificial intelligence to constantly measure and correct for environmental variables like wind speed and the level of the ground below it. "It's awesome to actually get to see this [automatic correction] occur," said Havard Grip, Ingenuity's chief pilot, in the same release. "It reinforces the accuracy of our modeling and our understanding of how to best operate Ingenuity."

An anonymous reader quotes a report from the Guardian: [R]esearchers have created a hi-tech option for canines left home alone: a ball that allows them to call their owners on the old dog and bone. The device -- nicknamed the DogPhone -- is a soft ball that, when moved, sends a signal to a laptop that launches a video call, and the sound of a ringing telephone. The owner can choose whether to take the call, and when to hang up, while they can also place a call to their pet -- although the dog has to move the ball to pick up.

The research, which is published in the Proceedings of the Association for Computing Machinery on Computer-Human interaction and is being presented at the 2021 ACM Interactive Surfaces and Spaces Conference in Lodz, Poland, reveals how [Dr Ilyena Hirskyj-Douglas, of the University of Glasgow, and first author of the research] and researchers from Aalto University in Finland settled on a soft ball to create the device. The DogPhone underwent a number of iterations to ensure it had the right level of sensitivity towards movement -- these were tested over 16 days by Hirskyj-Douglas and her nine-year-old black labrador, Zack.

A diary detailing the calls between owner and pet suggests the latter did not always seem to know what he was doing -- despite having been shown five times how the system worked. "Dog rang me but was not interested in our call instead was checking for things in his bed," Hirskyj-Douglas noted during the testing of one iteration. Another entry reveals the potential pitfalls of the DogPhone. "Dog walking around wagging and then laying down. I was in a meeting so had to hang up quickly," one record reveals. The team say that many of the calls made by Zack -- who was left alone for about eight hours during testing days -- appear to have been accidents although they caution that may simply be the human perspective. "For example, when the dog triggered the system with their butt, this could have been deliberate and the dog's unique way of triggering an interaction," they write.

UPDATE: While one group of physicians has complained that the FDA is slow-walking the release of vaccine-approval documents, Snopes.com points out you can also see this story from a different perspective: A scheduling dispute related to a Freedom of Information Act (FOIA) request for more than than 329,000 pages of COVID-19 vaccine data led to misleading social media posts in November 2021. The U.S. Food and Drug Administration (FDA) proposed a schedule to process and release 500 pages every month, arguing that this is the standard rate to process FOIA requests as "reviewing and redacting records for exempt information is a time-consuming process." The FDA would start releasing this data immediately, but the full set of pages would not be processed until 2076. The FDA argued that the amount of time required to fulfill this request is due to the broad FOIA request that involves hundreds of thousands of pages.
Snopes emphasizes that the FDA "did not request a delay in the release of its COVID-19 data until 2076," and notes they were responding to a request for the 329,000 pages in just 108 days with a very small number of qualified respondents. "Courts do not waiver from the standard 500 page per month processing rate even when a FOIA request would take years to process..." [reads the FDA's response]. "FDA has invited Plaintiff to narrow its request by specifying records it no longer wants FDA to process and release, and Plaintiff has declined to do so. If Plaintiff decides to request fewer records, then FDA will be able to complete its processing at an earlier date."
Snopes adds that the scheduling issue will be settled by a U.S. district judge next month.

Slashdot reader schwit1 had shared this report from Substack, written by Aaron Siri. He is the Managing Partner of Siri & Glimstad, a law firm representing the plaintiffs in the case. From the report: The FDA has asked (PDF) a federal judge to make the public wait until the year 2076 to disclose all of the data and information it relied upon to license Pfizer's COVID-19 vaccine. That is not a typo. It wants 55 years to produce this information to the public. As explained in a prior article, the FDA repeatedly promised "full transparency" with regard to Covid-19 vaccines, including reaffirming "the FDA's commitment to transparency" when licensing Pfizer's COVID-19 vaccine.

With that promise in mind, in August and immediately following approval of the vaccine, more than 30 academics, professors, and scientists from this country's most prestigious universities requested the data and information submitted to the FDA by Pfizer to license its COVID-19 vaccine. The FDA's response? It produced nothing. So, in September, my firm filed a lawsuit against the FDA on behalf of this group to demand this information. To date, almost three months after it licensed Pfizer's vaccine, the FDA still has not released a single page. Not one. Instead, two days ago, the FDA asked a federal judge to give it until 2076 to fully produce this information. The FDA asked the judge to let it produce the 329,000+ pages of documents Pfizer provided to the FDA to license its vaccine at the rate of 500 pages per month, which means its production would not be completed earlier than 2076. Further reading: FDA Wants 55 Years To Process FOIA Request Over Vaccine Data (Paywalled Reuters story)

An anonymous reader quotes a report from CNBC: The CDC's independent panel of vaccine scientists unanimously endorsed Pfizer and Moderna's boosters for all adults, one of the final regulatory steps before the U.S. can officially start distributing the doses. The Advisory Committee on Immunization Practices voted to recommend the shots. The Food and Drug Administration authorized both company's vaccine boosters for everyone 18 and over earlier on Friday, and CDC Director Rochelle Walensky is expected to clear the doses soon after. The panel's recommendation would open up eligibility to everyone 18 and over in the U.S., but the group more strongly endorsed shots for older Americans by saying everyone 50 and over should get a booster. It previously said people over 65 and some other high-risk people should get a third shot. Once Walensky signs off, tens of millions of Americans who've received their two initial shots at least six months ago will be eligible to get a third shot as soon as early as this weekend. "Pfizer said its booster dose was 95% effective at preventing symptomatic infection in people who had no evidence of prior infection in a clinical trial of 10,000 participants 16 years and older," notes CNBC. "Moderna didn't submit its efficacy data for its booster, telling the panel it was still gathering the data."

Abstract of a paper published on Nature: The use of psychedelic substances at sub-sensorium 'microdoses,' has gained popular academic interest for reported positive effects on wellness and cognition. The present study describes microdosing practices, motivations and mental health among a sample of self-selected microdosers (n = 4050) and non-microdosers (n = 4653) via a mobile application. Psilocybin was the most commonly used microdose substances in our sample (85%) and we identified diverse microdose practices with regard to dosage, frequency, and the practice of stacking which involves combining psilocybin with non-psychedelic substances such as Lion's Mane mushrooms, chocolate, and niacin. Microdosers were generally similar to non-microdosing controls with regard to demographics, but were more likely to report a history of mental health concerns. Among individuals reporting mental health concerns, microdosers exhibited lower levels of depression, anxiety, and stress across gender. Health and wellness-related motives were the most prominent motives across microdosers in general, and were more prominent among females and among individuals who reported mental health concerns. Our results indicate health and wellness motives and perceived mental health benefits among microdosers, and highlight the need for further research into the mental health consequences of microdosing including studies with rigorous longitudinal designs.

Apple co-founder Steve Wozniak's startup Privateer aims to help humanity get the goods on space junk before it's too late. Space.com reports: The Hawaii-based company, whose existence Wozniak and co-founder Alex Fielding announced in September, wants to characterize the ever-expanding space debris population like never before. Privateer will do this by incorporating a variety of data, including crowdsourced information and observations made by its own sizable satellite fleet. "I think we're looking at several hundred satellites," Privateer Chief Scientific Adviser Moriba Jah told Space.com. "We won't launch all several hundred at once; we'll just slowly build it up."

Orbital debris is already tracked by a number of organizations, including the U.S. military and private companies such as LeoLabs. Privateer wants to contribute to these efforts and help ramp them up, eventually creating the "Google Maps of space," as Fielding told TechCrunch last month. To make this happen, Privateer, which is still in "stealth mode" at the moment, plans to build and analyze a huge debris dataset that incorporates information from a variety of sources. "We want to basically be a company that's focused on decision intelligence by aggregating massive quantities of disparate and heterogeneous information, because there's something to be gained in the numbers," said Jah, a space debris expert who's also an associate professor of aerospace engineering and engineering mechanics at the University of Texas at Austin.

Privateer will purchase some of this information, crowdsource some of it and gather still more using its own satellites, Jah said. The first of those satellites is on track to launch this coming February, he added. This information will lead to much more than a census of space junk, if all goes according to plan. The company intends also to characterize debris objects, nailing down their size, shape and spin rate, among other features. "The catalogs of objects out there all treat things like they're spheres," Jah said. "We're going to take it beyond the sphere, to what the thing more realistically looks like and is." Such information will allow satellite operators and others in the space community to better gauge the threat posed by debris objects and improve their predictions about how long pieces of junk will stay aloft, he added. Privateer will make some of its analyses and data freely available for the public good and sell others to customers.

Tesseractic shares a report from New Scientist, written by Chen Ly: A satellite has been successfully powered by iodine for the first time. Iodine performed better than the traditional propellant of choice, xenon -- highlighting iodine's potential utility for future space missions. Currently, xenon is the main propellant used in electric propulsion systems, but the chemical is rare and expensive to produce. As a gas, xenon must also be stored at very high pressures, which requires specialized equipment. Iodine has a similar atomic mass to xenon but is more abundant and much cheaper. It can also be stored as an unpressurised solid, meaning it has the potential to simplify satellite designs.

Dmytro Rafalskyi at ThrustMe, a space technology company based in France, and his colleagues have developed an electric propulsion system that uses iodine. The propulsion system first heats up a solid block of iodine, turning it into a gas. The gas is bombarded with high-speed electrons, which turns it into a plasma of iodine ions and free electrons. Negatively charged hardware then accelerates the positively charged iodine ions from the plasma towards the system's exhaust and propels the spacecraft forwards. [...] The group found that the iodine system slightly outperformed xenon systems, with a higher overall energy efficiency, which showcases the viability of iodine as a propellant. "There are some difficulties with iodine that need to be addressed says Rafalskyi," the report adds. "For example, iodine reacts with most metals, so the team had to use ceramics and polymers to protect parts of the propulsion system. In addition, solid iodine takes about 10 minutes to turn into a plasma, which may not provide a propellant quickly enough for emergency maneuvers to avoid an in-orbit collisions."

The research has been published in the journal Nature.

An anonymous reader quotes a report from CNBC: Elon Musk on Wednesday said SpaceX is "hoping" to launch the first orbital flight test of its mammoth Starship rocket in January, a schedule that depends on testing and regulatory approval. "We'll do a bunch of tests in December and hopefully launch in January," Musk said, speaking at a meeting of the National Academies of Sciences, Engineering, and Medicine Space Studies Board.

The company's next major step in developing Starship is launching to orbit. First, the company needs a launch license from the Federal Aviation Administration for the mission, with the regulator expecting to complete a key environmental assessment by the end of this year. Musk noted that he wasn't sure if Starship would successfully reach orbit on the first try, but emphasized that he is "confident" that the rocket will get to space in 2022. "We intend to have a high flight rate next year," Musk said.

SpaceX aims to launch as many as a dozen Starship test flights next year, he said, to complete the "test flight program" and move to launching "real payloads in 2023." He stressed that creating a mass production line for Starship is crucial to the program's long-term goals, noting that the current "biggest constraint" on rocket manufacturing is how fast the company can build the Raptor engines needed for Starship. "I think, in order for life to become multiplanetary, we'll need maybe 1,000 ships or something like that," Musk said. "The overarching goal of SpaceX has been to advance space technology such that humanity can become a multi-planet species and, ultimately, a spacefaring civilization." SpaceX received a $2.9 billion contract from NASA to develop Starship for delivering astronauts to the moon's surface, but Musk said the company is "not assuming any international collaboration" or external funding for the rocket program. "[Starship] is at least 90% internally funded thus far," Musk said.

According to Amazon and Blue Origin founder Jeff Bezos, future generations "will visit Earth the way you visit Yellowstone National Park." Gizmodo reports: The remarks came last week at an event held at the National Cathedral in Washington, DC, with NASA Administrator Bill Nelson and others talking about space policy. Bezos sat down for a one-on-one chat with Adi Ignatius, the editor-in-chief of the Harvard Business Review. He brought up themes we've heard before, including his vision that all polluting industries will exist in space one day and that we'll all live on space colonies that could, in his estimation, support 1 trillion people. But he expanded on his vision in greater detail about what, exactly, will happen to the planet we'll all leave behind for Blue Origin-branded space colonies.

"This is the most precious planet in the world and we have to preserve it and conserve it and make sure that our children and their children and so on have this beauty in their lives," Bezos said. "We need to conserve what we have, restore what we've lost," he said. "This planet is so small, if we want to keep growing as a civilization, using energy as a civilization, most of that needs to be done off-planet. ... This place is special. You can't ruin it." To do that will require us all to live in space colonies. That would leave Earth to eventually be, in Bezos' vision, a place for future folks to visit but not live. "They may visit Earth the way you visit Yellowstone National Park," Bezos said. Ignatius asked a follow-up about who gets to live on Earth in this vision, which Bezos did not answer. "It's extremely telling that Bezos' vision for the future of Earth is Yellowstone National Park," comments Gizmodo's Brian Kahn, a former park ranger. "Bezos' big idea of turning Earth into Yellowstone elides the fact that humans are as much a part of this planet as they were part of Yellowstone before Americans showed up. He's pitching a very Western solution to the very Western problem of climate change and environmental degradation, problems that Bezos' very own businesses have played a major role in while enriching him to the point where he now has a huge sway on humanity's next step."

"NASA is not properly estimating costs for the Artemis program and could spend $93 billion between fiscal years 2021 and 2025," writes Slashdot reader schwit1. "NASA recently extended its target date for sending astronauts back to the moon to 2025 at the earliest." But, according to a new report (PDF) from NASA's Office of the Inspector General, it could be several years after 2024. The Verge reports: The recent prediction comes from NASA's Office of the Inspector General, which does periodic audits of the space agency's various programs. In its latest report, the OIG took a comprehensive look at NASA's Artemis program, the agency's ambitious initiative to send people back to the Moon, as well as land the first woman and the first person of color on the lunar surface. [...] NASA's Artemis program relies on a suite of complicated vehicles all working together to get astronauts safely to the Moon, including a massive new rocket called the Space Launch System, or SLS, that will send people to deep space inside a new crew capsule called Orion. Meanwhile, SpaceX is developing its next-generation spacecraft, called Starship, to carry people to and from the lunar surface for NASA -- part of a $2.9 billion contract awarded to the company in April.

However, Starship is still in very early stages of development and has yet to launch to orbit. SLS and Orion also have not flown on their first flight together. The OIG report, released Monday, highlights these issues and reveals just how much work is left to be done on Artemis, making a 2024 landing date unrealistic. "Given the time needed to develop and fully test the HLS and new spacesuits, we project NASA will exceed its current timetable for landing humans on the Moon in late 2024 by several years," the report states. [...] Rival space company Blue Origin had also hoped to receive a contract from NASA to develop a lunar lander, but when the space agency gave the award to SpaceX, the company sued in federal court. The lawsuit prevented NASA and SpaceX from working together on the lander until the litigation was resolved.

The OIG report notes that the lawsuit did have an impact on the overall schedule, but the office also argues that the development schedule for SpaceX's Starship is overly optimistic. SpaceX CEO Elon Musk continues to make bold predictions for Starship's first major test launch, claiming multiple times it'd be ready to fly to orbit for the first time this year. However, the OIG report estimates the first orbital flight test of Starship will occur sometime in the second quarter of 2022. The document does argue that SpaceX may be able to shave off some time due to its speedy testing pace compared with earlier NASA spaceflight programs. But there is still quite a lot of work to be done after Starship's orbital flight test. [...] The OIG report predicts that the debut of NASA's SLS rocket and Orion combo will also be delayed.

An anonymous reader quotes a report from The Verge: The Food and Drug Administration authorized a virtual reality system as a prescription treatment for chronic back pain, the agency announced today. The therapy, called EaseVRx, joins the short list of digital therapeutics cleared by the agency over the past few years. EaseVRx includes a VR headset and a device that amplifies the sound of the user's breath to assist in breathing exercises. It uses principles from cognitive behavior therapy, which aims to help people recognize and understand various thought patterns and emotions. The program addresses pain through relaxation, distraction, and improved awareness of internal signals, the FDA said in its statement.

The FDA authorized EaseVRx based on data from an eight-week study in 179 people with low back pain that had lasted six months or longer. Half used the EaseVRx program and half participated in another, two-dimensional virtual reality program that did not use cognitive behavioral therapy methods. Around two-thirds of participants using EaseVRx said they had more than 30 percent reduction in pain, while only 41 percent of the control group had a similar reduction. The reduced pain lasted for up to three months after the study for people in the EaseVRx group but not for the control group. The VR system could be an alternative option to opioid medications for back pain, Christopher Loftus, acting director of the Office of Neurological and Physical Medicine Devices at the FDA, said in a statement. [...] EaseVRx was developed by the company AppliedVR, which is also testing its platform as a treatment for fibromyalgia pain, burn pains, or pain during childbirth. The clearance for EaseVRx comes around a month after the FDA approved a VR treatment for children with the visual disorder amblyopia, or lazy eye.

A new space mission to hunt for potentially habitable planets around Earth's closest neighbouring star system is under way. From a report: In a project with echoes of the 2009 film Avatar, an international collaboration of scientists in Australia and the US will search in the Alpha Centauri star system for earth-like planets that could sustain life. Alpha Centauri -- Earth's closest neighbouring star system -- consists of two sun-like stars, known as Alpha Centauri A and B, and a more distant red dwarf star. The Toliman mission, named after the ancient Arabic-derived name for the star system, will search for potential planets orbiting Alpha Centauri A and B.

The Toliman telescope, which is under construction, is set to be launched into low-earth orbit in 2023. It seeks to discover new planets in the "Goldilocks orbit" -- at the right distance, so the planet is neither too hot nor too cold to sustain life. Project leader Prof Peter Tuthill, of the University of Sydney, said: "If we're looking for life as we know it, usually the gold standard is a planet where liquid water could be present at the surface of the planet â" so it's not like a frozen snowball, and it doesn't boil all the water up into the atmosphere." "We know that life has evolved at least once, around a sun-like star on an earth-like planet," Tuthill said. "We try to look for other examples that are as close to that configuration as possible."

It's one of the most intriguing questions about the Solar System from the last five years: Is there a large planet, lurking out in the cold dark reaches, on an orbit so wide it could take 20,000 years to complete? The answer has proven elusive, but a new study reveals what could be traces of the mysterious hypothetical object's existence. From a report: Astronomer Michael Rowan-Robinson of Imperial College London in the UK conducted an analysis of data collected by the Infrared Astronomical Satellite (IRAS) in 1983, and found a trio of point sources that just might be Planet Nine. This, Rowan-Robinson concludes in his preprint paper, is actually fairly unlikely to be a real detection, but the possibility does mean that it could be used to model where the planet might be now in order to conduct a more targeted search, in the quest to confirm or rule out its existence. "Given the poor quality of the IRAS detections, at the very limit of the survey, and in a very difficult part of the sky for far infrared detections, the probability of the candidate being real is not overwhelming," he wrote.

"However, given the great interest of the Planet 9 hypothesis, it would be worthwhile to check whether an object with the proposed parameters and in the region of sky proposed, is inconsistent with the planetary ephemerides." Speculation about the existence of a hidden planet in the outer reaches of the Solar System has swirled for decades, but it reached a new pitch in 2016 with the publication of a paper proposing new evidence. Astronomers Mike Brown and Konstantin Batygin of Caltech found that small objects in the outer Solar System's Kuiper Belt were orbiting oddly, as though pushed into a pattern under the gravitational influence of something large.

But finding the dratted thing is a lot more complicated than it might sound. If it is out there, it could be five to 10 times the mass of Earth, orbiting at a distance somewhere between 400 and 800 astronomical units (an astronomical unit is the average distance between Earth and the Sun; Pluto, for context, is around 40 astronomical units from the Sun). This object is very far away, and quite small and cold and probably not reflecting much sunlight at all; and, moreover, we don't know exactly where in the very large sky it is. So the jury is out on whether it is real or not, and the topic is one of pretty intense and interesting debate. IRAS operated for 10 months from January 1983, taking a far-infrared survey of 96 percent of the sky. In this wavelength, small, cool objects like Planet Nine might be detectable, so Rowan-Robinson decided to re-analyze the data using parameters consistent with Planet Nine.

An anonymous reader quotes a report from Ars Technica: The seven astronauts and cosmonauts onboard the International Space Station sheltered inside their respective spacecraft, a Crew Dragon and Soyuz, on Monday morning as the orbiting laboratory passed through an unexpected debris field. This was not a pre-planned collision avoidance maneuver in low Earth orbit, in which the station would use onboard propulsion to move away. Rather, the situation required the astronauts to quickly take shelter. Had there been a collision during the conjunction, the two spacecraft would have been able to detach from the space station and make an emergency return to Earth. Ultimately that was not necessary, and the astronauts reemerged into the space station later Monday. However, as the crew on board the station prepared for their sleep schedule, Mission Control in Houston asked them to keep as many of the hatches onboard the space station closed for the time being, in case of an unexpected collision during subsequent orbits.

It appears likely that the debris field that had alarmed flight controllers on Monday was caused by an anti-satellite test performed by Russia's military early on Monday. [...] It appears that Russia launched a surface-to-space Nudol missile on Monday, between 02:00 and 05:00 UTC, from the Plesetsk Cosmodrome in the northern part of the country. The missile then struck an older satellite, Cosmos 1408. Launched in 1982, the satellite had been slowly losing altitude and was a little more than 450 km above the Earth. This is a large satellite, with a mass of about 2,000 kg. As of Monday afternoon, US Space Command said it was already tracking more than 1,000 pieces of new debris. Although the satellite's altitude is higher than the International Space Station, which is about 400 km above the surface, a kinetic impact would spread a large cloud of debris. Satellite expert Jonathan McDowell believes the Cosmos 1408 satellite is the likely candidate for the space station's ongoing debris event.

During a daily briefing today, US State Department Spokesman Ned Price said the test had created more than 1,500 pieces of trackable debris and hundreds of thousands of pieces of un-trackable debris. "The Russian Federation recklessly conducted a destructive satellite test of a direct-ascent anti-satellite missile against one of its own satellites," Price said. "This test will significantly increase the risk to astronauts and cosmonauts on the International Space Station as well as to other human spaceflight activities. Russia's dangerous and irresponsible behavior jeopardizes the long-term sustainability of outer space."

Heavy rain and flooding in Aswan, Egypt, have driven drifts of scorpions to seek shelter in people's homes. From a report: Three people died and more than 400 were hospitalised across the governorate to receive anti-venom treatment after being stung by the panicking arachnids, according to state-run media. However, acting Health Minister Khalid Abdel-Ghafar said in a statement that no deaths were reported from the stings. The Ministry of Health has reassured the public that it holds a large enough stock of anti-venom, noting that 3,350 doses were available in Aswan. The downpours and subsequent floods have also forced local authorities to suspend schools on Sunday, Governor Ashraf Attia said.

fahrbot-bot shares a report from Phys.Org: A research team at the University of Wisconsin-Madison has identified a new way to convert ammonia to nitrogen gas through a process that could be a step toward ammonia replacing carbon-based fuels. The discovery of this technique, which uses a metal catalyst and releases -- rather than requires -- energy, was reported Nov. 8 in Nature Chemistry and has received a provisional patent from the Wisconsin Alumni Research Foundation.

The scientists were excited to find that the addition of ammonia to a metal catalyst containing the platinum-like element ruthenium spontaneously produced nitrogen, which means that no added energy was required. Instead, this process can be harnessed to produce electricity, with protons and nitrogen gas as byproducts. In addition, the metal complex can be recycled through exposure to oxygen and used repeatedly, all a much cleaner process than using carbon-based fuels. "We figured out that, not only are we making nitrogen, we are making it under conditions that are completely unprecedented," says Berry, who is the Lester McNall Professor of Chemistry and focuses his research efforts on transition metal chemistry. "To be able to complete the ammonia-to-nitrogen reaction under ambient conditions -- and get energy -- is a pretty big deal."

Ammonia has been burned as a fuel source for many years. During World War II, it was used in automobiles, and scientists today are considering ways to burn it in engines as a replacement for gasoline, particularly in the maritime industry. However, burning ammonia releases toxic nitrogen oxide gases. The new reaction avoids those toxic byproducts. If the reaction were housed in a fuel cell where ammonia and ruthenium react at an electrode surface, it could cleanly produce electricity without the need for a catalytic converter.

alaskana98 writes: In a recent GQ magazine interview with Luis Elizondo, the former head of the Department of Defense's "Advanced Aerospace Threat Identification Program (AATIP)," he claims that the much publicized "Tic-Tac" UAPs observed by the U.S. Navy have been flying in our skies for many decades: "I have in my possession official U.S. government documentation that describes the exact same vehicle that we now call the Tic Tac [seen by the Nimitz pilots in 2004] being described in the early 1950s and early 1960s and performing in ways that, frankly, can outperform anything we have in our inventory."

He then goes on to state that he's even heard from pilots who suffered real-world health issues as a consequence of getting too close to the objects: "I've got to be careful, I can't speak too specifically, but one might imagine that you get a report from a pilot who says, "Lue, it's really weird. I was flying and I got close to this thing and I came back home and it was like I got a sunburn. I was red for four days." Well, that's a sign of radiation. That's not a sunburn; it's a radiation burn."

Perhaps most bizarre is a revelation that those who got closest to the UAPs experienced a form of time dilation: "'You know, Lue, it's really bizarre. It felt like I was there for only five minutes, but when I looked at my watch 30 minutes went by, but I only used five minutes' worth of fuel. How is that possible?' Well, there's a reason for that, we believe, and it probably has to do with warping of space time. And the closer you get to one of these vehicles, the more you may begin to experience space time relative to the vehicle and the environment."

As the saying goes, extraordinary claims require extraordinary evidence -- but if these claims can be corroborated with evidence it would suggest that we've only seen the tip of the iceberg in terms of information that has yet to be revealed on these things. Perhaps the Unidentified Aerial Phenomena Task Force (UAPTF) will drive future efforts to get a better idea (PDF) of what this phenomenon actually is.

Last month 49-year-old Glen de Vries travelled with William Shatner into space with two other crewmembers on Blue Origin's sub-orbital capsule.

Today NBC News announced de Vries "was one of two men killed Thursday in a plane crash in New Jersey, officials said." Glen de Vries, 49, of New York City, and Thomas P. Fischer, 54, of Hopatcong, New Jersey, died following the small aircraft crash shortly before 3 p.m. in Hampton Township, according to New Jersey State Police...

De Vries co-founded software company Medidata Solutions, which specializes in management of electronic data from clinical trials. He also served as a trustee for Carnegie Mellon University in Pittsburgh. "We will truly miss Glen, but his dreams — which we share — live on: we will pursue progress in life sciences & healthcare as passionately as he did," Medidat said in a statement.
Newsweek reports that upon his return to earth, de Vries told a Pittsburgh TV station that space travel "is something we need to make accessible in an equitable way, to as many people on the planet as possible." In a tweet on Friday, Blue Origin wrote, "We are devastated to hear of the sudden passing of Glen de Vries."

"He brought so much life and energy to the entire Blue Origin team and to his fellow crewmates," the tweet continued. "His passion for aviation, his charitable work, and his dedication to his craft will long be revered and admired."

Scientists have identified what appears to be a small chunk of the moon that is tracking the Earth's orbit around the Sun. From a report: The asteroid, named Kamo'oalewa, was discovered in 2016 but until now relatively little has been known about it. New observations suggest it could be a fragment from the moon that was thrown into space by an ancient lunar collision. Kamo'oalewa is one of Earth's quasi-satellites, a category of asteroid that orbits the Sun, but remains relatively close to the planet -- in this case about 9m miles away.

Despite being close in astronomical terms, the asteroid is about the size of a ferris wheel and about 4m times fainter than the faintest star that can be seen with the naked eye. Consequently, the Earth's most powerful telescopes are needed to make observations. Using the Large Binocular Telescope on Mount Graham in southern Arizona, astronomers found the spectrum of reflected light from Kamo'oalewa closely matched lunar rocks from Nasa's Apollo missions, suggesting it originated from the moon. They had initially compared the light with that reflected off other near-Earth asteroids, but drawn a blank. "I looked through every near-Earth asteroid spectrum we had access to, and nothing matched," said Ben Sharkey, a PhD student at the University of Arizona and the paper's lead author.

fahrbot-bot shares a report from Scientific American: A diamond that formed deep in the earth's mantle contains a mineral never seen before in nature. The discovery is a rare glimpse into the deep mantle and may help reveal new information about the structure of the planet at depths of more than 660 kilometers. This, in turn, can help geologists better understand how the mantle controls the earth's plate tectonics.

The mineral, calcium silicate perovskite, only forms under the incredibly high pressures that occur deep in the earth. The newly identified sample likely formed between 660 and 900 km below the planet's surface, says mineralogist Oliver Tschauner of the University of Nevada, Las Vegas. Though the mineral had previously been synthesized in the laboratory using 20 gigapascals of pressure (almost 200,000 times atmospheric pressure), it had immediately reverted to a different form when it was removed from that artificial high-pressure environment. So researchers had assumed it would be impossible to retrieve naturally occurring calcium silicate perovskite from the mantle. "The chances, we thought, of finding it were so low that we never really actively looked for it," Tschauner says.

So it was a surprise when he and his colleagues, analyzing imperfections in a diamond from Orapa, Botswana, found three minuscule specks of calcium silicate perovskite. Calcium silicate is found in other forms, including wollastonite in the crust and breyite in the middle and lower regions of the mantle. But this version had a telltale cubic crystal structure that marked it as different from those versions of the mineral. Tschauner and his colleagues named the new mineral "davemaoite," after geologist Ho-Kwang "Dave" Mao, who carried out some of the pioneering experiments in using diamonds as presses to experimentally generate mantlelike pressures on the earth's surface. They announced the discovery on Thursday in Science.

An anonymous reader quotes a report from International Business Times: US scientists have developed a new form of drug that promotes the regeneration of cells and reversed paralysis in mice with spinal injuries, allowing them to walk again within four weeks of treatment. The research was published in the journal Science on Thursday, and the team of Northwestern University scientists behind it hope to approach the Food and Drug Administration as early as next year to propose human trials. [Northwestern's Samuel Stupp, who led the study, and his team] used nanofibers to mimic the architecture of the "extracellular matrix" -- a naturally occurring network of molecules surrounding tissue that is responsible for supporting cells. Each fiber is about 10,000 times narrower than a human hair, and they are made up of hundreds of thousands of bioactive molecules called peptides that transmit signals to promote nerve regeneration. The therapy was injected as a gel into tissue surrounding the spinal cords of lab mice 24 hours after an incision was made in their spines.

The team decided to wait a day because humans who receive devastating spinal injuries from car accidents, gunshots and so on also experience delays in getting treatment. Four weeks later, mice who received the treatment regained their ability to walk almost as well as before the injury. Those left untreated did not. The mice were then put down to examine the impacts of the therapy on the cellular level, and the team found dramatic improvements to the spinal cords. The severed extensions of neurons called axons regenerated, and scar tissue that can act as a physical barrier to regeneration was significantly diminished. What's more, an insulating layer of axons called myelin that is important in transmitting electric signals had reformed, blood vessels that deliver nutrients to injured cells had formed, and more motor neurons survived.

A key discovery by the team was that creating a certain mutation in the molecules intensified their collective motion and heightened their efficacy. This is because receptors in neurons are naturally in constant motion, Stupp explained, and increasing the motion of the therapeutic molecules within the nanofibers helps connect them more effectively with their moving targets. The researchers in fact tested two versions of the treatment -- one with the mutation and one without -- and found that mice that received the modified version regained more function. The gel developed by the scientists is the first of its kind, but could usher in a new generation of medicines known as "supramolecular drugs," because the therapy is an assembly of many molecules rather than a single molecule, said Stupp. According to the team, it is safe because the materials biodegrade within a matter of weeks and become nutrients for cells. Stupp said he hopes to rapidly move direct to human studies next without the need for further animal testing, such as on primates.

SpaceX's Crew Dragon spacecraft successfully docked with the International Space Station on Thursday evening, less than 24 hours after it launched from NASA's Kennedy Space Center. Fox Business reports: NASA astronauts Raja Chari, Tom Marshburn, and Kayla Barron, as well as European Space Agency astronaut Matthias Maurer, will spend six months at the ISS conducting scientific research and monitoring the space station. The launch was supposed to occur nearly two weeks ago, but was delayed by bad weather and an undisclosed medical problem with a crew member. Wednesday's launch carried the 600th person to ever reach orbit and comes just days after SpaceX returned four astronauts to Earth on Monday, bringing an end to a 200-day mission at the space station.

AI systems being developed to diagnose skin cancer run the risk of being less accurate for people with dark skin, research suggests. From a report: The potential of AI has led to developments in healthcare, with some studies suggesting image recognition technology based on machine learning algorithms can classify skin cancers as successfully as human experts. NHS trusts have begun exploring AI to help dermatologists triage patients with skin lesions. But researchers say more needs to be done to ensure the technology benefits all patients, after finding that few freely available image databases that could be used to develop or "train" AI systems for skin cancer diagnosis contain information on ethnicity or skin type. Those that do have very few images of people with dark skin.

Dr David Wen, first author of the study from the University of Oxford, said: "You could have a situation where the regulatory authorities say that because this algorithm has only been trained on images in fair-skinned people, you're only allowed to use it for fair-skinned individuals, and therefore that could lead to certain populations being excluded from algorithms that are approved for clinical use. Alternatively, if the regulators are a bit more relaxed and say: 'OK, you can use it [on all patients]', the algorithms may not perform as accurately on populations who don't have that many images involved in training." That could bring other problems including risking avoidable surgery, missing treatable cancers and causing unnecessary anxiety, the team said.

The use of whole genome sequencing could save the NHS millions of pounds, a study suggests, after it found a quarter of people with rare illnesses received a diagnosis for their condition through the technology. From a report: In some cases, the findings have provided reassurance for families that they have not passed their condition on to their children, while in others they have inspired life-changing treatments. Though individually uncommon, rare inherited diseases affect about 6% of the UK population, or roughly 3 million people. Traditionally, geneticists searched for the abnormalities underpinning such conditions by looking at the person's chromosomes through a microscope, but this is no good at spotting tiny, but often highly significant changes, such as single letter substitutions in the genetic code. Because of this, "many of the people who have a rare disease either live very long diagnostic odysseys to get an answer for why they are like they are, or they do not get an answer in their entire lifetime," said Prof Sir Mark Caulfield at Queen Mary University of London (QMUL), a former chief scientist at Genomics England. In 2013, the UK government launched the 100,000 Genomes Project to investigate whether WGS -- which involves reading through the entire 3bn pairs of letters in the human genome -- could help doctors better understand the cause of patients' symptoms, and identify other family members who may be at risk. Five years later, NHS England became the first national health care system in the world to offer WGS to people with undiagnosed rare diseases and cancer as part of routine care.

An anonymous reader quotes a report from Phys.Org: A University of Arizona-led effort to reconstruct Earth's climate since the last ice age, about 24,000 years ago, highlights the main drivers of climate change and how far out of bounds human activity has pushed the climate system. The study, published this week in Nature, had three main findings:

1.) It verified that the main drivers of climate change since the last ice age are rising greenhouse gas concentrations and the retreat of the ice sheets.
2.) It suggests a general warming trend over the last 10,000 years, settling a decade-long debate about whether this period trended warmer or cooler in the paleoclimatology community.
3.) The magnitude and rate warming over the last 150 years far surpasses the magnitude and rate of changes over the last 24,000 years.

There are different methods for reconstructing past temperatures. The team combined two independent datasets -- temperature data from marine sediments and computer simulations of climate -- to create a more complete picture of the past. The researchers looked at the chemical signatures of marine sediments to get information about past temperatures. Because temperature changes over time can affect the chemistry of a long-dead animal's shell, paleoclimatologists can use those measurements to estimate temperature in an area. It's not a perfect thermometer, but it's a starting point. Computer-simulated climate models, on the other hand, provide temperature information based on scientists' best understanding of the physics of the climate system, which also isn't perfect. The team decided to combine the methods to harness the strengths of each. This is called data assimilation and is also commonly used in weather forecasting. [...] Now, the team is working on using their method to investigate climate changes even farther in the past.

nickwinlund77 shares a report from SciTechDaily: Since the first observation of merging black holes by the Laser Interferometer Gravitational-Wave Observatory (LIGO) in 2015, astronomers have been repeatedly surprised by their large masses. Though they emit no light, black hole mergers are observed through their emission of gravitational waves -- ripples in the fabric of spacetime that were predicted by Einstein's theory of general relativity. Physicists originally expected that black holes would have masses less than about 40 times that of the Sun, because merging black holes arise from massive stars, which can't hold themselves together if they get too big. The LIGO and Virgo observatories, however, have found many black holes with masses greater than that of 50 suns, with some as massive as 100 suns. Numerous formation scenarios have been proposed to produce such large black holes, but no single scenario has been able to explain the diversity of black hole mergers observed so far, and there is no agreement on which combination of formation scenarios is physically viable. This new study, published in the Astrophysical Journal Letters, is the first to show that both large and small black hole masses can result from a single pathway, wherein the black holes gain mass from the expansion of the universe itself.

Astronomers typically model black holes inside a universe that cannot expand. "It's an assumption that simplifies Einstein's equations because a universe that doesn't grow has much less to keep track of," said Kevin Croker, a professor at the UH Mnoa Department of Physics and Astronomy. "There is a trade-off though: predictions may only be reasonable for a limited amount of time." Because the individual events detectable by LIGO-Virgo only last a few seconds, when analyzing any single event, this simplification is sensible. But these same mergers are potentially billions of years in the making. During the time between the formation of a pair of black holes and their eventual merger, the universe grows profoundly. If the more subtle aspects of Einstein's theory are carefully considered, then a startling possibility emerges: the masses of black holes could grow in lockstep with the universe, a phenomenon that Croker and his team call cosmological coupling. The most well-known example of cosmologically-coupled material is light itself, which loses energy as the universe grows. "We thought to consider the opposite effect," said research co-author and UH Manoa Physics and Astronomy Professor Duncan Farrah. "What would LIGO -- Virgo observe if black holes were cosmologically coupled and gained energy without needing to consume other stars or gas?"

An anonymous reader quotes a report from The Guardian: Scientists have shown how a fatty acid found in palm oil can encourage the spread of cancer, in work that could pave the way for new treatments. The study, on mice, found that palmitic acid promoted metastasis in mouth and skin cancers. In future, this process could be targeted with drugs or carefully designed eating plans, but the team behind the work cautioned against patients putting themselves on diets in the absence of clinical trials. The study adds to emerging evidence that diet can be used to enhance existing cancer treatments because certain nutrients are disproportionately relied on by tumor cells, or are required at critical stages such as metastasis.

The study built on previous work by the same team showing that, within a tumor, just a small subset of cells have the capacity to spread by traveling out of the tumor, reaching other organs and colonizing them. These specialized cancer cells appeared to rely particularly heavily on fatty acids and the latest work narrowed this down to palmitic acid, which is found in palm oil -- but also in a wide variety of foods such as butter and olive oil. The study, published in Nature, found that when palmitic acid was supplemented into the diet of mice, mouth and skin cancers were more likely to spread. Other fatty acids called oleic acid and linoleic acid -- omega-9 and omega-6 fats found in foods such as olive oil and flaxseeds -- did not show the same effect. Neither of the fatty acids tested increased the risk of developing cancer in the first place. The study suggested that exposure to palmitic acid caused changes to the function of genes in cancer cells that allowed them to sense fatty acids and consume them more efficiently. The presence of palmitic acid also appeared to send cancer cells into a "regenerative state" allowing them to form signaling networks beyond the tumor, which is known to be a crucial step towards spreading.

Camel Pilot writes: SpinLaunch is developing a launch system that uses kinetic energy as a cheap method to launch a projectile into orbit. They propose using a vacuum-sealed centrifuge spinning the projectile at near escape velocity speeds and releasing into orbit. A rocket engine would still be used to maneuver and position the satellite. They have built a 1/10th scale prototype in the New Mexican desert and have already launched test objects 10s of thousands of feet.

In a recent interview, CEO Jonathan Yaney said: "I find that the more audacious and crazy the project is, the better off you are just working on it -- rather than being out there talking about it. We had to prove to ourselves that we could actually pull this off."

An anonymous reader quotes a report from Bloomberg: Unsealed emails reveal the role baby-powder maker Johnson & Johnson played in a report that an industry group submitted to U.S. regulators deciding whether to keep warnings off talc-based products linked to cancer. The emails -- unsealed in the state of Mississippi's lawsuit against J&J over its refusal to add a safety warning -- show J&J and its talc supplier chose the scientists hired by their trade association, the Personal Care Products Council, to write the 2009 report assessing talc-based powders' health risks. They also show the researchers changed the final version of their report at the companies' behest. The U.S. Food and Drug Administration said it relied in part on the report in its decision to forgo a warning for the product.

The emails among executives of J&J and Rio Tinto Minerals, its supplier at the time, provide a behind-the-scenes glimpse of dealings between companies and their industry group that successfully fended off a cancer warning on talc-based powders for nearly 40 years. Now, almost 39,000 users and their families are suing J&J, most claiming their ovarian cancers and those of loved ones were linked to asbestos, the potent carcinogen in the products pulled from U.S. and Canadian shelves in May 2020. Dependence on industry data creates a situation that's ripe for lobbyists to exert pressure on the FDA. The unsealed emails pull back the curtain on how such efforts get launched, who pays for them, and who has a hand in delivering the final product to regulators.

While the practice of companies having a say in industry group submissions to the FDA isn't new or illegal, the emails reveal just how involved J&J got in a report meant to assess product safety -- down to selecting individual scientists to produce it and having them write an executive summary. J&J denied any wrongdoing in its decision not to acknowledge its input to the report that the PCPC lobbying group sent to the FDA. [...] FDA officials acknowledged they weighed the PCPC's response to the citizens' petitions demanding a warning for talc-based powders before finding there was "inconclusive evidence" the mineral caused ovarian and other forms of cancer. "The FDA reviewed and considered all of the information submitted to us in the two petitions, the comments received in response to the petitions, and additional scientific information," said Tara Rabin, a spokeswoman.

Astronomers have detected a record number of gravitational waves, in a discovery they say will shed light on the evolution of the universe, and the life and death of stars. From a report: An international team of scientists have made 35 new observations of gravitational waves, which brings the total number of detections since 2015 to 90. Gravitational waves are ripples in the fabric of spacetime, created by massive cosmic events -- such as pairs of black holes smashing together -- up to billions of light years away. Waves from these cataclysmic collisions were detected by the Laser Interferometer Gravitational-Wave Observatory (Ligo) observatory in the US and the Virgo instrument in Italy between November 2019 and March 2020. The first detection of gravitational waves, announced in 2016, confirmed a prediction Albert Einstein made a century earlier based on his general theory of relativity. Monash University researcher Shanika Galaudage, a collaborator in the Australian branch of the project known as OzGrav, described gravitational waves as a game-changing "new window into the universe."

"Another space agency, about one-tenth the size of NASA, is thinking outside of the planet-sized box in its search for Martian life," reports CNET: With its Martian Moons Exploration mission (or MMX), the Japan Aerospace Exploration Agency, or JAXA, later this decade will touch down on a world no spacecraft has visited before: Phobos, one of Mars' mystifying moons. Scientists at JAXA, and other astronomers, hypothesize that on this curious moon they may find signs of ancient microbes that were catapulted off the surface of Mars and flung across the cosmos. The remains of these unwitting spacefaring organisms have been untouched for millions of years and, soon, could be plucked from Phobos' face and returned to Earth.

When an asteroid collides with a planet, the planet unleashes a mighty sneeze of dust and rock. The faster the asteroid smashes into the surface, the bigger the sneeze... [I]f the asteroid impact is powerful enough, the sneeze will fling dust and rock into space... Just like a human sneeze contains microbes, the material ejected by a planet may also contain microscopic life — or the remnants of it. If the asteroid death blast doesn't melt the rock and the microbes to mere atoms, there's a chance they can float into the cosmos... Mars is scarred by impacts from drifter asteroids that slammed into the surface over the planet's life. If these impacts were to hit in just the right spot, at just the right angle and just the right time, there's a chance the ejected material would make it to Phobos, Mars' curious, potato-shaped moon. Phobos has the closest orbit of any known moon to its parent body, circling the red planet at a distance of just 6,000 kilometers (3,700 miles), about the same as the distance between Tokyo and Honolulu....

Phobos is practically hugging Mars, and moves around the planet so quickly that if you were to observe it from the surface, you'd be able to see it rise and set twice every Martian day. Its proximity to the red planet has led JAXA scientists and engineers to speculate about the potential for finding the remnants of Martian microbes on the moon's surface. "If Martian life once existed and was widespread elsewhere on Mars, the chance that its dead remains exist also on Phobos is, in my opinion, relatively high," says Ryuki Hyodo, a planetary scientist at JAXA's Institute of Space and Astronautical Science... It's possible, JAXA believes, that Phobos could be a satellite cemetery, unwittingly holding molecular evidence of long-dead microorganisms....

With a planned sample return date of 2029, MMX would be the first time samples have been returned from the Martian sphere. While the space agency estimates just 0.1% of Phobos' soil likely originated on Mars, there's a chance MMX could bring back the first samples of the red planet to Earth.

Long-time Slashdot reader fahrbot-bot shared this report from the New York Times about a "particularly unusual" star about 150 light-years away that's orbited by three planets: What's unusual is the inclinations of the outer two planets, HD 3167 c and d. Whereas in our solar system all the planets orbit in the same flat plane around the sun, these two are in polar orbits. That is, they go above and below their star's poles, rather than around the equator as Earth and the other planets in our system do.

Now scientists have discovered the system is even weirder than they thought. Researchers measured the orbit of the innermost planet, HD 3167 b, for the first time — and it doesn't match the other two. It instead orbits in the star's flat plane, like planets in our solar system, and perpendicular to HD 3167 c and d. This star system is the first one known to act like this...

The unusual configuration of HD 3167 highlights just how weird and wonderful other stars and their planets can be. "It puts in perspective again what we think we know about the formation of planetary systems," said Vincent Bourrier from the University of Geneva in Switzerland, who led the discovery published last month in the journal Astronomy & Astrophysics.

"Planets can evolve in really, really different ways."

So how exactly did the universe come into existence? "A recent astronomical measurement recorded in a laboratory at the South Pole is causing scientists to revisit their theories..." writes Don Lincoln, a senior scientist at the Fermi National Accelerator Laboratory: In the intervening decades [since 1929], observations have only strengthened the case for the Big Bang theory, but they have also made it clear that the theory is incomplete. For instance, in its earliest incarnation, the Big Bang couldn't explain why the universe was so uniform. Astronomers in the Northern Hemisphere who looked deep into space see the same thing on average as ones that live in the Southern Hemisphere. Traditional Big Bang theory predicts that there should be small differences in temperature, clumpiness of large clusters of galaxies and other properties. But both sides look the same.

However, in 1980, physicist Alan Guth proposed an extension to the theory that could reconcile some of the inconsistencies between theory and observation, including the unexpected uniformity. His extension is called cosmic inflation theory and it claims that in the first moments of the birth of the universe it expanded faster than the speed of light.... However, if inflation is true, we should be able to prove it. Although the universe was once glowing hot, the expansion of the universe has cooled it off and that glow has morphed into microwaves that astronomers have been able to detect since 1964. This relic of the Big Bang is called the cosmic microwave background, or CMB. Inflation theory predicts that the microwaves of the CMB should be polarized...

The CMB can be polarized in two ways: B-modes, which are swirly patterns, and E-modes, which are more of a straight-line pattern. And, if inflation theory is correct, we'd expect to see some mix of B-modes and E-modes, while if it isn't correct — in other words, if the expansion of the universe did not happen as quickly as the theory suggests — researchers should only see E-modes... Astronomers used a telescope facility called BICEP-3 (short for Background Imaging of Cosmic Extragalactic Polarization) to study the CMB and its polarization. The telescope's South Pole location, with its altitude of nearly two miles above sea level and incredibly dry air, is an ideal place to conduct this kind of research. BICEP-3 scientists combined their data with measurements at other facilities and found no indication of B-modes originating from the CMB. If B-modes are present in the CMB, they are very small.

So, does that mean that the theory of inflation must be thrown out? No, although the data has disproved some of the simpler theories of inflation, it isn't sensitive enough to rule out the more complex versions. Still, the failure to observe CMB B-modes is unsettling, causing some scientists to go back to the drawing board.

An anonymous reader quotes a report from Green Market Report: Exclusively-natural psychedelic drug discovery company Filament Health Corp. received authorization from the FDA authorization to initiate the first clinical trial using naturally-sourced psychedelic substances. The news caused the stock to jump over 11% in early trading. The company said that this approval is the first for the direct administration of psilocin rather than its prodrug psilocybin and will administer Filament's three proprietary botanical drug candidates. The phase 1 trial is led by the Translational Psychedelic Research Program (TrPR) at the University of California San Francisco (UCSF).

The phase 1 trial has been designed to include 20 healthy subjects and will examine the effects of Filament's three proprietary botanical drug candidates: PEX010 (oral psilocybin), PEX020 (oral psilocin), and PEX030 (sublingual psilocin). As a result of the need for psilocybin to convert into psilocin before becoming active in the human body, the direct administration of psilocin may yield several therapeutic benefits such as faster onset time, greater consistency, increased bioavailability, and lessened side effects. These potential attributes are being studied in the authorized trial. In addition, psilocin is an ideal candidate for sublingual delivery because of the bypassing of the gut, where the conversion to psilocybin is thought to primarily occur. To date, synthetic manufacturers have been unable to produce a stable formulation of psilocin and enter it into a clinical trial. "We are excited to announce this milestone as validation of our ability to cultivate variable psychedelic biomass and transform it into pharmaceutical-grade drug candidates," said Chief Executive Officer, Benjamin Lightburn. "Our innovative technology has allowed us to create IP-protected botanical drug candidates of oral psilocin, sublingual psilocin, and oral psilocybin, and to enter them into an FDA-approved natural psychedelic clinical trial. Our candidates enjoy significant IP protection, unlike most other psychedelics currently under clinical investigation."

Amazon's Kuiper Systems asked U.S. regulators for permission to launch another 4,538 satellites that would bolster its constellation as it competes with Elon Musk's SpaceX for broadband-from-space customers. From a report: The additions would bring Kuiper's constellation to 7,774 satellites, the company said in a filing Thursday with the Federal Communications Commission. The companies are joining a rush to offer internet service from orbits near the Earth, spurred in a part by decreasing launch costs. Low orbits offer minimal lag time for data to bounce between a user on the ground and the spacecraft. Kuiper's request was among nine applications, submitted under an FCC deadline, that requested authorization for a total of more than 35,000 spacecraft. That's more than seven times the number aloft today. Those figures don't include nearly 30,000 additional satellites proposed by segment leader SpaceX, which already has launched more than 1,700 of its Starlink spacecraft.

Uneven vaccine coverage and a relaxation of preventive measures have brought Europe to a "critical point" in the pandemic, the World Health Organization has said, with cases again at near-record levels and 500,000 more deaths forecast by February. From a report: Hans Kluge, the WHO's Europe director, said all 53 countries in the region were facing "a real threat of Covid-19 resurgence or already fighting it" and urged governments to reimpose or continue with social and public health measures. "We are, once again, at the epicentre," he said. "With a widespread resurgence of the virus, I am asking every health authority to carefully reconsider easing or lifting measures at this moment." He said that even in countries with high vaccination rates, immunisation could only do so much.

"The message has always been: do it all," Kluge said. "Vaccines are doing what was promised: preventing severe forms of the disease and especially mortality ... But they are our most powerful asset only if used alongside public health and social measures." Catherine Smallwood, WHO Europe's senior emergency officer, said countries that had mostly lifted preventive measures had experienced a surge in infections.

About half of the world's fossil fuel assets will be worthless by 2036 under a net zero transition, according to research. From a report: Countries that are slow to decarbonise will suffer but early movers will profit; the study finds that renewables and freed-up investment will more than make up for the losses to the global economy. It highlights the risk of producing far more oil and gas than required for future demand, which is estimated to leave $11tn-$14tn in so-called stranded assets -- infrastructure, property and investments where the value has fallen so steeply they must be written off. The lead author, Jean-Francois Mercure of the University of Exeter, said the shift to clean energy would benefit the world economy overall, but it would need to be handled carefully to prevent regional pockets of misery and possible global instability. "In a worst-case scenario, people will keep investing in fossil fuels until suddenly the demand they expected does not materialise and they realise that what they own is worthless. Then we could see a financial crisis on the scale of 2008," he said, warning oil capitals such as Houston could suffer the same fate as Detroit after the decline of the US car industry unless the transition is carefully managed.

Pfizer's oral antiviral drug was found to reduce the risk of hospitalization or death from COVID-19 by 89%, according to interim results from a mid-to-late-stage study announced by the company on Friday. From a report: Antiviral drugs can be a key pandemic-fighting tool, as not everyone will get vaccinated against the virus and it may take years to fully inoculate people in certain countries -- particularly given current gaps in global vaccine supplies. Pfizer CEO Albert Bourla said in a statement that these findings from the phase 2/3 study marked "a real game-changer in the global efforts to halt the devastation of this pandemic." Pfizer's antiviral pill, PAXLOVID (PF-07321332), was developed specifically to treat COVID-19, by blocking activity of the main enzyme the virus needs to multiply. This was co-administered with a low dose of ritonavir, which is widely used in combination treatments for HIV infection.

An anonymous reader quotes a report from The Guardian: The virus that causes Covid-19 does not infect human brain cells, according to a study published in the journal Cell. The findings will raise hopes that the damage caused by Sars-CoV-2 might be more superficial and reversible than previously feared. The study contradicts earlier research that suggested the virus infects neurons in the membrane that lines the upper recesses of the nose. This membrane, called the olfactory mucosa, is where the virus first lands when it is inhaled. Within it are olfactory sensory neurons (OSNs), which are responsible for initiating smell sensations. They are tightly entwined with a kind of support cell called sustentacular cells.

In the new study, Belgian and German researchers claim that the virus infects sustentacular cells but not OSNs. "That is just a critical distinction," said the senior author Peter Mombaerts, who directs the Max Planck Research Unit for Neurogenetics in Frankfurt, Germany. "Once you believe that olfactory neurons can be infected, there is a quick route into the olfactory bulb and then you're in the brain already." The olfactory bulb, at the front of the brain, is where neural input about odors is first processed. If the virus penetrated this structure it could theoretically spread to deeper brain regions where it could do lasting damage -- especially since, unlike OSNs, most neurons are not regenerated once lost. But if the virus only infects the sustentacular cells, then the damage could be less long-lasting. Both pathways could explain the olfactory dysfunction that afflicts an estimated half of all Covid-19 patients. In one in 10 of those, the loss or change of smell is long-term, perhaps permanent. Mombaerts says this could be the result of support for the OSNs breaking down, even if they themselves are not infected. They may function below par, or stop functioning altogether, until the sustentacular cells regenerate.

Scientists identified a specific gene that doubles the risk of respiratory failure from Covid-19 and may go some way to explaining why some ethnic groups are more susceptible to severe disease than others. From a report: Researchers from the University of Oxford found that a higher-risk version of the gene most likely prevents the cells lining airways and the lungs from responding to the virus properly. About 60% of people with South Asian ancestry carry this version of the gene, compared with 15% of people with European heritage, according to the study published Thursday. The findings help explain why higher rates of hospitalization and death may have been seen in certain communities and on the Indian subcontinent. The authors cautioned that the gene cannot be used as a sole explanation as many other factors, such as socioeconomic conditions, play a role. Despite a significant impact from the virus to people with Afro-Caribbean ancestry, only 2% carry the higher-risk genotype. People with the gene, known as LZTFL1, would particularly benefit from vaccination, which remains the best method of protection, the authors said. The findings raise the possibility of research into treatments specific to patients with this gene, though no tailored drugs are currently available.

Google owner Alphabet has launched an artificial intelligence company to discover new drugs. From a report: UK-registered Isomorphic Labs will use technology from its sister company DeepMind to "to accelerate drug discovery, and ultimately, find cures for some of humanity's most devastating diseases," said Demis Hassabis, the head of DeepMind, in a blog post. He added that he would also become the chief executive of Isomorphic Labs. Scientists around the world were awed in July when DeepMind unveiled how its AlphaFold2 technology could be used to predict the shape of every protein in the human body with almost perfect accuracy.

DeepMind's model can solve one of the trickiest problems in biology by taking a sequence of amino acids and mapping the twists and turns of its shape. The algorithm could help replace or enhance painstaking laboratory work to identify the structures of proteins, which dictate how they behave. Pharmaceutical companies and academic researchers are eager to use the tool -- which DeepMind has made available on an open source basis -- to discover new targets for drugs. Its speed could cut the time to discovering innovative treatments, although the process of clinical trials is still likely to take several years. DeepMind said it would use the technology to try to find treatments for Chagas disease and Leishmaniasis, two of the most deadly diseases in the world.

Months-long silences. Mysterious rejections. Here's what's behind the shortages of a critical tool for ending the pandemic. ProPublica: A few weeks ago, a ProPublica reporter decided to test his kids for COVID-19. They had the sniffles, and with a grandparent set to visit he wanted to minimize the risk that they were infectious. This was the problem that quick, cheap COVID-19 tests were supposed to help fix. No need to go to a clinic or wait days for results. Just pick up a pack of tests at a local pharmacy whenever you want, swab your nose and learn within 15 minutes if you're likely to pass the virus along. So the ProPublican went to his neighborhood CVS, hoping to buy the required pack of two for $23.99. They were out of stock. Then he went to Rite Aid. They didn't have the tests either. Then Walgreens, then another CVS. All out of stock. The only supplier with a few tests to offer was his sister, who happened to have a few tucked away. It's a familiar experience for many Americans. But not for people in Britain, who get free rapid tests delivered to their homes on demand. Or France, Germany or Belgium, where at-home tests are ubiquitous and as cheap as a decent cappuccino. So why are at-home tests still so pricey and hard to find in the United States?

The answer appears to be a confounding combination of overzealous regulation and anemic government support -- issues that have characterized America's testing response from the beginning of the pandemic. Companies trying to get the Food and Drug Administration's approval for rapid COVID-19 tests describe an arbitrary, opaque process that meanders on, sometimes long after their products have been approved in other countries that prioritize accessibility and affordability over perfect accuracy. After the FDA put out a call for more rapid tests in the summer of 2020, Los Angeles-based biotech company WHPM, Inc. began working on one. They did a peer-reviewed trial following the agency's directions, then submitted the results this past March. In late May, WHPM head of international sales Chris Patterson said, the company got a confusing email from its FDA reviewer asking for information that had in fact already been provided. WHPM responded within two days. Months passed. In September, after a bit more back and forth, the FDA wrote to say it had identified other deficiencies, and wouldn't review the rest of the application. Even if WHPM fixed the issues, the application would be "deprioritized," or moved to the back of the line.

"We spent our own million dollars developing this thing, at their encouragement, and then they just treat you like a criminal," said Patterson. Meanwhile, the WHPM rapid test has been approved in Mexico and the European Union, where the company has received large orders. An FDA scientist who vetted COVID-19 test applications told ProPublica he became so frustrated by delays that he quit the agency earlier this year. "They're neither denying the bad ones or approving the good ones," he said, asking to remain anonymous because his current work requires dealing with the agency. FDA officials said they simply want to ensure that rapid tests detect even low levels of the virus, since false negative test results could cause people to unwittingly spread the disease. They blame the test shortages on an absence of the kind of sustained public funding that European governments have provided. Without it, manufacturers have lacked confidence that going through the FDA's process would be financially worth the trouble.

The first pill designed to treat symptomatic Covid has been approved by the UK medicines regulator. From a report: The tablet -- molnupiravir -- will be given twice a day to vulnerable patients recently diagnosed with the disease. In clinical trials the pill, originally developed to treat flu, cut the risk of hospitalisation or death by about half. Health Secretary Sajid Javid said the treatment was a "gamechanger" for the most frail and immunosuppressed. In a statement he said: "Today is a historic day for our country, as the UK is now the first country in the world to approve an antiviral that can be taken at home for Covid."

Molnupiravir, developed by the US drug companies Merck, Sharp and Dohme (MSD) and Ridgeback Biotherapeutics, is the first antiviral medication for Covid which can be taken as a pill rather than injected or given intravenously. The UK has agreed to purchase 480,000 courses with the first deliveries expected in November. Initially it will be given to both vaccinated and unvaccinated patients through a national study, with extra data on its effectiveness collected before any decision to order more. The drug needs to be given within five days of symptoms developing to be most effective. It's not immediately clear how it will be distributed so quickly by the NHS. It's thought some care homes may be offered supplies while other elderly or vulnerable patients may be prescribed it by their GP after testing positive for Covid.

On Monday, A group of diplomats from the United Kingdom proposed that the United Nations set up a group to develop new norms of international behavior in space, with the aim of preventing the kinds of misunderstandings that could lead to war. Wired reports: As spacefaring nations advance their military satellite capabilities, including being able to disrupt or damage other satellites, such provocative behavior could escalate already-tense diplomatic situations -- and create more space debris in low earth orbit, a crucial region that's already chock-full of derelict spacecraft. This is the first significant progress in developing space rules in more than four decades. The most important piece of space law, the Outer Space Treaty, was negotiated by the fledgling space powers in 1967.

Monday's vote before the UN's First Committee, which is focused on international security and disarmament, passed overwhelmingly, with representatives of 163 countries voting yea versus eight nays and nine abstentions. Considering the widespread support for the proposal, including backing from the Biden administration, Edmondson expects it to pass in the full UN General Assembly next month. The proposal would create a new working group at the UN that will meet twice a year in Geneva in 2022 and 2023. By the end of that time, the group must reach consensus on new rules and identify areas in need of further investigation. Crafting norms for the kinds of activities that escalate tensions or generate debris will likely be top priority for this group, says Cassandra Steer, an expert on space law and space security at the Australian National University in Canberra.

Joshua Chou writes via The Conversation: Last month the Australian Space Agency announced plans to send an Australian-made rover to the Moon by as early as 2026, under a deal with NASA. The rover will collect lunar soil containing oxygen, which could eventually be used to support human life in space. Although the deal with NASA made headlines, a separate mission conducted by private companies in Australia and Canada, in conjunction with the University of Technology Sydney, may see Australian technology hunting water on the Moon as soon as mid-2024. If all goes according to plan, it will be the first rover with Australian-made components to make it to the Moon.

The ten-kilogram rover, measuring 60x60x50cm, will be launched on board the Hakuto lander made by ispace, a lunar robotic exploration company based in Japan. The rover itself, also built by ispace, will have an integrated robotic arm created by the private companies Stardust Technologies (based in Canada) and Australia's EXPLOR Space Technology (of which I am one of the founders). Using cameras and sensors, the arm will collect high-resolution visual and haptic data to be sent back to the mission control centre at the University of Technology Sydney. It will also collect information on the physical and chemical composition of lunar dust, soil and rocks -- specifically with a goal of finding water. We know water is present within the Moon's soil, but we have yet to find a way to extract it for practical use.