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Medicine

Doctor Walmart Will See You Now (economist.com) 46

American retailers see opportunities in the primary-care business. From a report: With his long white coat, stethoscope, genially soothing manner and wonky eagerness to discuss "population health management" and "patient-centred" medicine, Ronald Searcy seems the Platonic ideal of a primary-care doctor. The most unusual thing about him is where he works: a compact facility complete with examination rooms, dentist's office, phlebotomy lab and X-ray room tucked into a Walmart in north-west Arkansas. Since 2019, Walmart has opened 32 of these "health centres" in five states; by the end of next year it plans to more than double that number, and expand into two more states. Walmart is not the only big company expanding its medical offerings.

[...] What do these companies see in the medical business? The answer, befitting America's Byzantine and rent-filled health-care system, is both simple and complex. The simple answer is money. Americans spend a stunning amount of it on health: roughly 18% of GDP in 2021, far exceeding the rich-country average of about 10% and more than double the ratio of some, such as South Korea, with healthier and longer-lived populations. Americans' spending is forecast to rise by 5.4% per year over the next eight years, outpacing economic growth and accounting for almost 20% of GDP by 2031. The bulk of that spending will come from Medicaid and Medicare, federal programmes that cover health-care costs for, respectively, poor people and over-65s. The complex part reflects changes in how insurers, including Medicaid and Medicare, pay for coverage; as well as changes in how consumers are willing to get it.

Science

Microsoft Says Its Weird New Particle Could Improve Quantum Computers (newscientist.com) 32

An anonymous reader quotes a report from New Scientist: Microsoft researchers have made a controversial claim that they have seen evidence of an elusive particle that could solve some of the biggest headaches in quantum computing, but some experts are questioning the discovery. Quantum computers process information using quantum bits, or qubits, but current iterations can be prone to error. "What the field needs is a new kind of qubit," says Chetan Nayak at Microsoft Quantum. He and his colleagues say they have taken a significant step towards building qubits from quasiparticles, which are not true particles but collective vibrations that can emerge when particles like electrons act together. The quasiparticles in question are called Majorana zero modes, which act as their own antiparticle and have a charge and energy that equate to zero. That makes them resilient to disturbances -- so they could make unprecedentedly reliable qubits -- but also makes them notoriously hard to find. The Microsoft researchers say devices they built exhibited behaviors consistent with Majorana zero modes. The main components of each device were an extremely thin semiconducting wire and a piece of superconducting aluminum.

This isn't the first time Microsoft has claimed to have found Majorana zero modes. A 2018 paper by a different group of researchers at the company was retracted from the scientific journal Nature in 2021 after it didn't hold up to scrutiny. At the time, Sergey Frolovat the University of Pittsburgh in Pennsylvania and his colleagues found that imperfections in the semiconductor wire could produce quantum effects easily mistaken for Majorana zero modes. "To see Majorana zero modes, the wire must be like a very long, very even road with no bumps. If there is any disorder in the wire, electrons can get stuck on these imperfections and assume quantum states that mimic Majorana zero modes," says Frolov. In the new experiment, the team used a more complex test called the topological gap protocol. To pass the test, a device must simultaneously show signatures of Majorana zero modes at each end of the wire, and also show that the electrons are in an energy range where a special kind of superconductivity emerges. "Rather than look for one particular simple signature of Majorana zero modes, we looked for a mosaic of signatures," says Nayak. The researchers tested this protocol on hundreds of computer simulations of devices, which considered any impurities in the wires, before using it on experimental data. Nayak says they calculated that for any device that passed the topological gap protocol, the probability of there not actually being a Majorana zero mode within it was less than 8 per cent.

Not all researchers in the field are convinced.Henry Leggat the University of Basel in Switzerland and his colleagues recently published a set of calculations showing that this test can be fooled by impurities in the wires. "The topological gap protocol as currently implemented is certainly not loophole free," he says. Frolov says that a few details imply that what seem to be Majorana zero modes would be revealed as an effect of disorder if the experiment were repeated with even more sensitive measurements. These include small differences between measurements for the left and right edges of the wire, as well as the measurements of electrons' energies -- the same energies can be indicative of emerging Majorana zero modes or of dirt trapping the electrons. Anton Akhmerovat the Delft University of Technology in the Netherlands says that for him, the new experiment is not viable evidence that Majorana zero modes have been detected until another team of researchers reproduces it. But this may be difficult as some details of how Microsoft's devices were manufactured have not been published on account of being trade secrets, he says.

Education

US Reading and Math Scores Drop To Lowest Level In Decades (npr.org) 248

The average test scores for 13-year-old students in the U.S. have decreased in reading and math since 2020, reaching the lowest levels in decades, with more significant declines in math. NPR reports: The average scores, from tests given last fall, declined 4 points in reading and 9 points in math, compared with tests given in the 2019-2020 school year, and are the lowest in decades. The declines in reading were more pronounced for lower performing students, but dropped across all percentiles. The math scores were even more disappointing. On a scale of 500 points, the declines ranged from 6 to 8 points for middle and high performing students, to 12 to 14 points for low performing students.

The math results also showed widening gaps based on gender and race. Scores decreased by 11 points for female students over 2020 results, compared with a 7-point decrease for male students. Among Black students, math scores declined 13 points, while white students had a 6-point drop. Compared with the 35-point gap between Black and white students in 2020, the disparity widened to 42 points.

While the scores show a drop from the pre-pandemic years, the results also show that there are other factors at work. The decline is even more substantial when compared with scores of a decade ago: The average scores declined 7 points in reading and 14 points in mathematics. The Education Department says plans are underway to address the learning loss. [...] The latest results are from the NAEP Long-Term Trend Assessment, traditionally administered every four years by the National Center for Education Statistics.

Biotech

US Approves Chicken Made From Cultivated Cells, the Nation's First 'Lab-Grown' Meat (apnews.com) 110

An anonymous reader quotes a report from The Associated Press: For the first time, U.S. regulators on Wednesday approved the sale of chicken made from animal cells, allowing two California companies to offer "lab-grown" meat to the nation's restaurant tables and eventually, supermarket shelves. The Agriculture Department gave the green light to Upside Foods and Good Meat, firms that had been racing to be the first in the U.S. to sell meat that doesn't come from slaughtered animals -- what's now being referred to as "cell-cultivated" or "cultured" meat as it emerges from the laboratory and arrives on dinner plates. The companies received approvals for federal inspections required to sell meat and poultry in the U.S. The action came months after the U.S. Food and Drug Administration deemed that products from both companies are safe to eat. A manufacturing company called Joinn Biologics, which works with Good Meat, was also cleared to make the products.

Cultivated meat is grown in steel tanks, using cells that come from a living animal, a fertilized egg or a special bank of stored cells. In Upside's case, it comes out in large sheets that are then formed into shapes like chicken cutlets and sausages. Good Meat, which already sells cultivated meat in Singapore, the first country to allow it, turns masses of chicken cells into cutlets, nuggets, shredded meat and satays. But don't look for this novel meat in U.S. grocery stores anytime soon. Cultivated chicken is much more expensive than meat from whole, farmed birds and cannot yet be produced on the scale of traditional meat, said Ricardo San Martin, director of the Alt:Meat Lab at University of California Berkeley. The companies plan to serve the new food first in exclusive restaurants: Upside has partnered with a San Francisco restaurant called Bar Crenn, while Good Meat dishes will be served at a Washington, D.C., restaurant run by chef and owner Jose Andres.

Medicine

For First Time, US Task Force Recommends Screening Adults For Anxiety Disorders 174

An anonymous reader quotes a report from CNN: Adults ages 19 to 64 in the United States should be screened for anxiety disorders, according to a new recommendation from the US Preventive Services Task Force released Tuesday. The final recommendation, published in the medical journal JAMA, marks the first time the USPSTF has made a final recommendation on screening for anxiety disorders in adults, including those who are pregnant and postpartum. The task force found "insufficient evidence" to screen for anxiety in older adults. The USPSTF, a group of independent medical experts whose recommendations help guide doctors' decisions and influence insurance plans, also continues to recommend that all adults be screened for major depressive disorder, including those who are pregnant or postpartum and older adults. The recommendation is consistent with the task force's 2016 recommendation on depression screenings.

While rates of clinical depression had been rising steadily in the United States, they jumped significantly during the Covid-19 pandemic. In general, about 1 in 6 adults will have depression at some time in their life, according to the US Centers for Disease Control and Prevention. And although depression and anxiety are different conditions, they commonly can happen together -- and such screening recommendations can help clinicians identify which patients may need treatment for both conditions or one versus the other. "Anxiety disorders are common, and they can really impact people's quality of life, and what the task force found is that screening for anxiety disorders in the general adult population can lead to identifying these conditions early and then, if those people who are identified get linked up with appropriate care, they will benefit," said Dr. Michael Silverstein, vice chair of the USPSTF and director of the Hassenfeld Child Health Innovation Institute at Brown University. "So it really is extremely good news for the delivery of preventive services for the American public," he said. "We also found that in the older adult population, which is defined as age 65 and older, that the task force really needs more evidence to weigh the risks and benefits of screening for anxiety disorders. And for that older adult population, we're calling for urgent new research."

USPSTF researchers noted in their anxiety screening recommendation statement that most people with anxiety disorders don't receive treatment within the first year of symptoms, if ever -- showing a need for more robust screening. "Only 11% of US adults with an anxiety disorder started treatment within the first year of onset; the median time to treatment initiation was 23 years," the researchers wrote. "A US study of 965 primary care patients found that only 41% of patients with an anxiety disorder were receiving treatment for their disorder." Once the new screening recommendations are practiced in the real world, the results may reveal that anxiety disorders are much more prevalent than previously thought, said Dr. Georges Benjamin, executive director of the American Public Health Association, who was not involved in the recommendation statements.
"Anxiety has been way under the radar for a long time, and so I think it's good that they are recommending for the broad population to be screened. When we start screening for anxiety, we're going to find a lot more of it than we thought we had," he said.

"I think it's an opportunity for us to get our hands around this crisis before we have a mental health emergency," Benjamin added. "So we definitely have to do more. We know as a nation, we have under-invested in mental health. We have not put as much money into mental health. We have not been treating mental health at the same level as physical health. And we know that people who need mental health services are really struggling to find providers to care for them."
Science

Short Daytime Naps May Keep Brain Healthy as It Ages, Study Says (theguardian.com) 47

Taking a short nap during the day may help to protect the brain's health as it ages, researchers have suggested after finding that the practice appears to be associated with larger brain volume. From a report: While previous research has suggested long naps could be an early symptom of Alzheimer's disease, other work has revealed that a brief doze can improve people's ability to learn. Now researchers say they have found evidence to suggest napping may help to protect against brain shrinkage. That is of interest, the team say, as brain shrinkage, a process that occurs with age, is accelerated in people with cognitive problems and neurodegenerative diseases, with some research suggesting this may be related to sleep problems.

"In line with these studies, we found an association between habitual daytime napping and larger total brain volume, which could suggest that napping regularly provides some protection against neurodegeneration through compensating for poor sleep," the researchers note. Writing in the journal Sleep Health, researchers at UCL and the University of the Republic in Uruguay report how they drew on data from the UK Biobank study that has collated genetic, lifestyle and health information from 500,000 people aged 40 to 69 at recruitment. The team used data from 35,080 Biobank participants to look at whether a combination of genetic variants that have previously been associated with self-reported habitual daytime napping are also linked to brain volume, cognition and other aspects of brain health.

Space

Webb Telescope Is Powerful Enough To See a Variety of Biosignatures In Exoplanets, Argues New Paper (phys.org) 39

A new study argues that the James Webb Space Telescope (JWST) is capable of detecting the chemical signs of life in exoplanet atmospheres -- the best hope for finding life on another world. Phys.Org reports: The team simulated atmospheric conditions for five broad types of Earth-like worlds: an ocean world, a volcanically active world, a rocky world during the high bombardment period, a super-Earth, and a world like Earth when life arose. They assumed all these worlds had a surface pressure of less than five Earth atmospheres, and calculated the absorption spectra for several organically produced molecules such as methane, ammonia, and carbon monoxide. These molecules can also be formed by non-biological methods, but they form a good baseline as a proof of concept.

They found that with a reasonably thick atmosphere, the JWST, specifically its NIRSpec G395M/H instrument, could confirm the presence of these molecules within 10 transits of the planet. It would be easiest to do with super-Earths and other worlds with a thick atmosphere, but it is still possible for potentially habitable worlds. Given the number of transits needed, our best shot at detecting biosignatures with JWST would be the close-orbiting worlds of red dwarf stars, such as the Trappist-1 system, which has several potentially habitable Earth-sized planets. Given the overlap between biological and non-biological origins, JWST observations might not be enough to confirm the existence of life, but this study shows that we are very close to that ability.

Earth

Seaweed Farming For CO2 Capture Would Take Up Too Much of the Ocean 99

An anonymous reader quotes a report from MIT Technology Review: If we're going to prevent the gravest dangers of global warming, experts agree, removing significant amounts of carbon dioxide from the atmosphere is essential. That's why, over the past few years, projects focused on growing seaweed to suck CO2 from the air and lock it in the sea have attracted attention -- and significant amounts of funding -- from the US government and private companies including Amazon. The problem: farming enough seaweed to meet climate-change goals may not be feasible after all.

A new study, published today in Nature Communications Earth & Environment, estimates that around a million square kilometers of ocean would need to be farmed in order to remove a billion tons of carbon dioxide from the atmosphere over the course of a year. It's not easy to come by that amount of space in places where seaweed grows easily, given all the competing uses along the coastlines, like shipping and fishing. To put that into context, between 2.5 and 13 billion tons of atmospheric carbon dioxide would need to be captured each year, in addition to dramatic reductions in greenhouse-gas emissions, to meet climate goals, according to the study's authors.

A variety of scientific models suggest we should be removing anything from 1.3 billion tons of carbon dioxide each year to 29 billion tons by 2050 in order to prevent global warming levels from rising past 1. 5C. An 2017 report from the UN estimated that we'd need to remove 10 billion tons annually to stop the planet from warming past 2C by the same date. "The industry is getting ahead of the science," says Isabella Arzeno-Soltero, a postdoctoral scholar at Stanford University, who worked on the project. "Our immediate goal was to see if, given optimal conditions, we can actually achieve the scales of carbon harvests that people are talking about. And the answer is no, not really." [...] Their findings suggest that cultivating enough seaweed to reach these targets is beyond the industry's current capacity, although meeting climate goals will require much more than reliance solely on seaweed.
Space

Scientists Hope Euclid Telescope Will Reveal Mysteries of Dark Matter (theguardian.com) 44

In just a few weeks, a remarkable European probe will be blasted into space in a bid to explore the dark side of the cosmos. From a report:ÂThe $1bn Euclid mission will investigate the universe's two most baffling components: dark energy and dark matter. The former is the name given to a mysterious force that was shown -- in 1998 -- to be accelerating the expansion of the universe, while the latter is a form of matter thought to pervade the cosmos, provide the universe with 80% of its mass, and act as a cosmic glue that holds galaxies together. Both dark energy and dark matter are invisible and astronomers have only been able to infer their existence by measuring their influence on the behaviour of stars and galaxies.

"We cannot say we understand the universe if the nature of these dark components remains a mystery," said astrophysicist Prof Andy Taylor of Edinburgh University. "That is why Euclid is so important." Taylor added that UK scientists had played a key role in designing and building the probe. For example, one of its two main instruments, the craft's Vis imager, was mostly built in the UK. "We thought what would be the biggest, most fundamentally important project we could do?" Taylor said. "The answer was Euclid, which has now been designed, built and is ready for launch." Euclid was intended to be launched last year on a Russian Soyuz rocket. However, after the invasion of Ukraine, the European Space Agency ended its cooperation with the Russian space agency, Roscosmos, and instead signed a deal to use a Falcon 9 rocket from Elon Musk's SpaceX company.

Science

Scientists Conduct First Test of a Wireless Cosmic Ray Navigation System (arstechnica.com) 36

An anonymous reader shares a report: GPS is now a mainstay of daily life, helping us with navigation, tracking, mapping, and timing across a broad spectrum of applications. But it does have a few shortcomings, most notably not being able to pass through buildings, rocks, or water. That's why Japanese researchers have developed an alternative wireless navigation system that relies on cosmic rays, or muons, instead of radio waves, according to a new paper published in the journal iScience. The team has conducted its first successful test, and the system could one day be used by search and rescue teams, for example, to guide robots underwater or to help autonomous vehicles navigate underground.

"Cosmic-ray muons fall equally across the Earth and always travel at the same speed regardless of what matter they traverse, penetrating even kilometers of rock," said co-author Hiroyuki Tanaka of Muographix at the University of Tokyo in Japan. "Now, by using muons, we have developed a new kind of GPS, which we have called the muometric positioning system (muPS), which works underground, indoors and underwater."

Space

How The JWST Could Detect Signs of Life on Exoplanets (universetoday.com) 25

Universe Today reports: The best hope for finding life on another world isn't listening for coded messages or traveling to distant stars, it's detecting the chemical signs of life in exoplanet atmospheres. This long hoped-for achievement is often thought to be beyond our current observatories, but a new study argues that the James Webb Space Telescope (JWST) could pull it off.

Most of the exoplanets we've discovered so far have been found by the transit method. This is where a planet passes in front of its star from our point of view. Even though we can't observe the planet directly, we can see the star's brightness dip by a fraction of a percent. As we watch stars over time, we can find a regular pattern of brightness dips, indicating the presence of a planet. The star dips in brightness because the planet blocks some of the starlight. But if the planet also has an atmosphere, there is a small amount of light that will pass through the atmosphere before reaching us. Depending on the chemical composition of the atmosphere, certain wavelengths will be absorbed, forming absorption spectra within the spectra of the starlight.

We have long been able to identify atoms and molecules by their absorption and emission spectra, so in principle, we can determine a planet's atmospheric composition with the transit method... We have done this with a few exoplanets, such as detecting the presence of water and organic compounds, but these were done for large gas planets with thick atmospheres. We haven't been able to do this with rocky Earth-like worlds. Our telescopes just aren't sensitive enough for that.

But this new study shows that the JWST could detect certain chemical biosignatures depending on their abundance in the atmosphere.

Long-time Slashdot reader Baron_Yam writes that "The signature I like to imagine detecting is actually industrial pollution. Chemicals that aren't created by any known geological process and indicate not just life, but life smart enough to have advanced technology (but stupid enough to pollute their own air supply)."
Space

Researchers Argue Earth Formed Much Faster Than Believed, Suggest More Planets Could Have Water (msn.com) 17

An anonymous reader quotes this report from the Washington Post: In a new study released in Nature this week, researchers state that Earth formed within just 3 million years. That's notably faster than previous estimates placing the timeline up to 100 million years.... "We can also predict that if other planets formed ... by the same mechanism, then the ingredients required for life such as water, should be present on other planets and other systems, so there's a greater chance that we have water worlds elsewhere in the galaxy," said Isaac Onyett, lead author of the study and Ph.D. candidate at the University of Copenhagen.

The authors assert that this rapid genesis occurred through a theory called pebble accretion. The general idea, according to co-author and cosmochemist Martin Bizzarro, is that planets are born in a disk of dust and gas. When they reach a certain size, they rapidly attract those pebbles like a vacuum cleaner. Some of those pebbles are icy and could provide a water supply to Earth, thought of as pebble snow. This would have led to an early version of our planet, known as proto-Earth, that is approximately half the size of our present-day planet. (Our current rendition of Earth likely formed after a larger impact about 100 million years later, which also led to the formation of our moon....)

The team determined the time scale of Earth's formation by looking at silicon isotopes from more than 60 meteorites and planetary bodies in the vicinity of Earth, which represent the rubble leftover after planet formation... By analyzing the silicon compositions in samples of different ages, Onyett said they can piece together a time sequence of what was happening in the disk of dust before Earth formed. They found that, as the samples increased in age, the composition of the asteroids changed toward the composition of the cosmic dust that was being accumulated by Earth. "That's very strong evidence that this dust was also being swept up as it was drifting inwards towards the Sun," said Onyett. "It would have been swept up by Earth as it was growing by accretion."

Birger Schmitz, an astrogeologist at Lund University who was not involved in the research, said these results are "very compelling" and could shift how we think about our planet's formation... Most importantly, he said the results show there is nothing special about our water-carrying planet. "It is just a very ordinary planet in our galaxy. This is important in our attempts to understand how common higher forms of life are in the universe."

While scientists agree pebble accretion does explain the formation of gas-giant planets like Jupiter and Saturn, some still argue that rocky planets like Earth were instead formed through larger and larger asteroid collisions...
Medicine

A Startup Tries Making Medicine in Space (cnn.com) 21

"California startup Varda Space Industries launched its first test mission on June 12," reports CNN, "successfully sending a 200-pound (90-kilogram) capsule designed to carry drug research into Earth's orbit.

"The experiment, conducted in microgravity by simple onboard machines, aims to test whether it would be possible to manufacture pharmaceuticals in space remotely." Research has already established that protein crystals grown in a weightless environment can result in more perfect structures compared with those grown on Earth. These space-formed crystals could potentially then be used to create better-performing drugs that the human body can more easily absorb.
"Its research, company officials hope, could lead to better, more effective drugs — and hefty profits," CNN reported earlier this week: "It's not as sexy a human-interest story as tourism when it comes to commercialization of the cosmos," said Will Bruey, Varda's CEO and cofounder. "But the bet that we're making at Varda is that manufacturing is actually the next big industry that gets commercialized." Varda launched its first test mission Monday aboard a SpaceX rocket, which took off from Vandenberg Space Force Base in California just after 2:30 pm PT. The company then confirmed in a tweet that its satellite successfully separated from the rocket...

If successful, Varda hopes to scale its business rapidly, sending regular flights of satellites into orbit stuffed with experiments on behalf of pharmaceutical companies. Eventually, the firm hopes that research will yield a golden ticket drug, one that proves to be better when manufactured in space and can return royalties to Varda for years to come... Founded less than three years ago, Varda has gone from an idea to a company with more than $100 million in seed funding and grants, a 68,000-square-foot factory, and a satellite in space. Its workforce has grown to nearly 100 employees...

One day, the company hopes Varda flights will be so common that its capsules will blaze across the night sky every evening, like shooting stars to those on the ground who catch a glimpse. From there, Varda could even look to develop a research platform on a private space station, where pharma researchers could travel themselves.

Medicine

Gas Stoves Pollute Homes With Benzene, Which Is Linked To Cancer 297

Researchers at Stanford University found that among the pollutants emitted from gas stoves is benzene, which is linked to cancer. "Levels of benzene can reach higher than those found in secondhand tobacco smoke and the benzene pollution can spread throughout a home," reports NPR. From the report: Stanford scientists measured benzene from gas stoves in 87 California and Colorado homes in 2022 for the paper published in the journal Environmental Science and Technology. They found both natural gas and propane stoves "emitted detectable and repeatable levels of benzene that in some homes raised indoor benzene concentrations above well-established health benchmarks." The risks of benzene have long been known. The Centers for Disease Control and Prevention says the chemical is linked to leukemia and other blood cell cancers.

"Benzene forms in flames and other high-temperature environments, such as the flares found in oil fields and refineries. We now know that benzene also forms in the flames of gas stoves in our homes," said Rob Jackson in a statement. He's the study's senior author and a Stanford professor of earth sciences. With one burner on high or the oven at 350 degrees, the researchers found benzene levels in a house can be worse than average levels for second-hand tobacco smoke. And they found the toxin doesn't just stay in the kitchen, it can migrate to other places, such as bedrooms. "Good ventilation helps reduce pollutant concentrations, but we found that exhaust fans were often ineffective at eliminating benzene exposure," Jackson said. He says this is the first paper to analyze benzene emissions when a stove or oven is in use.

Researchers also tested whether cooking food - pan-frying salmon or bacon - emits benzene but found all the pollution came from the gas and not the food. That's important because the gas industry often deflects concern about pollution from its fuel, to breathing problems that can be triggered by cooking fumes. There are no studies out there that say cooking with gas will make someone sick. This is all about increasing risks for certain illnesses.
Encryption

The US Navy, NATO, and NASA Are Using a Shady Chinese Company's Encryption Chips (wired.com) 45

New submitter ole_timer shares a report from Wired: TikTok to Huawei routers to DJI drones, rising tensions between China and the US have made Americans -- and the US government -- increasingly wary of Chinese-owned technologies. But thanks to the complexity of the hardware supply chain, encryption chips sold by the subsidiary of a company specifically flagged in warnings from the US Department of Commerce for its ties to the Chinese military have found their way into the storage hardware of military and intelligence networks across the West. In July of 2021, the Commerce Department's Bureau of Industry and Security added the Hangzhou, China-based encryption chip manufacturer Hualan Microelectronics, also known as Sage Microelectronics, to its so-called "Entity List," a vaguely named trade restrictions list that highlights companies "acting contrary to the foreign policy interests of the United States." Specifically, the bureau noted that Hualan had been added to the list for "acquiring and ... attempting to acquire US-origin items in support of military modernization for [China's] People's Liberation Army."

Yet nearly two years later, Hualan -- and in particular its subsidiary known as Initio, a company originally headquartered in Taiwan that it acquired in 2016 -- still supplies encryption microcontroller chips to Western manufacturers of encrypted hard drives, including several that list as customers on their websites Western governments' aerospace, military, and intelligence agencies: NASA, NATO, and the US and UK militaries. Federal procurement records show that US government agencies from the Federal Aviation Administration to the Drug Enforcement Administration to the US Navy have bought encrypted hard drives that use the chips, too. The disconnect between the Commerce Department's warnings and Western government customers means that chips sold by Hualan's subsidiary have ended up deep inside sensitive Western information networks, perhaps due to the ambiguity of their Initio branding and its Taiwanese origin prior to 2016. The chip vendor's Chinese ownership has raised fears among security researchers and China-focused national security analysts that they could have a hidden backdoor that would allow China's government to stealthily decrypt Western agencies' secrets. And while no such backdoor has been found, security researchers warn that if one did exist, it would be virtually impossible to detect it.

"If a company is on the Entity List with a specific warning like this one, it's because the US government says this company is actively supporting another country's military development," says Dakota Cary, a China-focused research fellow at the Atlantic Council, a Washington, DC-based think tank. "It's saying you should not be purchasing from them, not just because the money you're spending is going to a company that will use those proceeds in the furtherance of another country's military objectives, but because you can't trust the product." [...] The mere fact that so many Western government agencies are buying products that include chips sold by the subsidiary of a company on the Commerce Department's trade restrictions list points to the complexities of navigating the computing hardware supply chain, says the Atlantic Council's Cary. "At minimum, it's a real oversight. Organizations that should be prioritizing this level of security are apparently not able to do so, or are making mistakes that have allowed for these products to get into their environments," he says. "It seems very significant. And it's probably not a one-off mistake."

Earth

Action To Tackle Air Pollution Failing To Keep Up With Research 40

Globally, outdoor air pollution is second only to tobacco as greatest cause of lung and respiratory cancers. From a report: This year marks a decade since the International Agency for Research on Cancer (IARC) gathered in Lyon, France, to unanimously declare that air pollution caused cancer in humans. Air pollution was classified as a type 1 carcinogen, the most certain category possible. This was mainly based on more than 20 years of research in particle pollution and lung cancer. The number of research studies has almost doubled since the IARC meeting in Lyon, with even more evidence on lung cancer in never-smokers, but governmental action to reduce air pollution has not kept up.

Globally, outdoor air pollution is second only to tobacco as the greatest cause of lung and respiratory cancers. This holds true in almost all parts of the world, with a notable exception of low-income countries where people (especially women and children) also breathe smoke in their homes from cooking on open fires. In the past 10 years new studies have linked air pollution to other cancers, including breast and bladder cancer. These have also been associated with nitrogen dioxide, a pollutant from diesel traffic that is being targeted by low emissions zones in many cities. There is emerging evidence of links to childhood leukaemia too. For those people with lung cancer, smokers and never-smokers, their prognosis and survival appears to be reduced if they live in a polluted area. Research includes a recent study of more than a quarter of a million people with lung cancer in Pennsylvania. This raises questions about the impact of air pollution on the way that cancer progresses and how it may change the effectiveness of chemotherapy.
Science

Venture Capital's AI-Run Lettuce Farms Start To Go Bust (bloomberg.com) 71

The pitch for vertical farming had all the promise of a modern venture capital dream: a new way to grow crops that would use robots and artificial intelligence to conserve water, combat food insecurity and save the environment. But after firms poured billions of dollars into these startups, pushing valuations into the stratosphere, the industry is now facing a harsh new reality: funding is drying up, profits remain elusive, and creditors are circling. From a report: AeroFarms last week became the latest, most high-profile example of the challenges facing the business, filing for bankruptcy after building a massive new facility in Virginia that drained its cash, according to court papers. Its collapse comes on the heels of lettuce grower Kalera seeking court protection in April. And in May, publicly traded AppHarvest, which operates high-tech greenhouses, received a notice of default from one of its investors, according to a regulatory filing. The company contests the default notice, but if it can't reach an agreement with its creditors, the firm warned it could become "bankrupt or insolvent."

"We really were in a hype cycle," said Vonnie Estes, vice president of innovation for the International Fresh Produce Association. Venture capitalists entered the scene in a frenzy, likening these companies to software firms, and expecting comparable returns. "There was a lot of money that rushed in without really understanding that this is actually just farming." Industry experts still say that indoor farming is a crucial piece of agriculture's future, especially as climate change spurs more destructive wildfires and floods. Nonetheless, the ability of vertical farms to carve out meaningful market share on a national scale could be years away, they note.

Space

Saturn's Icy Moon Enceladus Harbors Essential Elements For Life (reuters.com) 29

Researchers have discovered high concentrations of phosphorus in ice crystals emitted from Saturn's moon Enceladus, enhancing its potential to support life. The findings, based on data from NASA's Cassini spacecraft, suggest that Enceladus may possess the necessary elements for life. Reuters reports: The discovery was based on data collected by NASA's Cassini spacecraft, the first to orbit Saturn, during its 13-year landmark exploration of the gaseous giant planet, its rings and its moons from 2004 to 2017. The same team previously confirmed that Enceladus' ice grains contain a rich assortment of minerals and complex organic compounds, including the ingredients for amino acids, associated with life as scientists know it. But phosphorus, the least abundant of six chemical elements considered necessary to all living things -- the others are carbon, oxygen, hydrogen, nitrogen and sulphur -- was still missing from the equation until now.

"It's the first time this essential element has been discovered in an ocean beyond Earth," the study's lead author, Frank Postberg, a planetary scientist at the Free University in Berlin, said in a JPL press release. [...] One notable aspect of the latest Enceladus discovery was geochemical modeling by the study's co-authors in Europe and Japan showing that phosphorus exists in concentrations at least 100 times that of Earth's oceans, bound water-soluble forms of phosphate compounds. "This key ingredient could be abundant enough to potentially support life in Enceladus' ocean," said co-investigator Christopher Glein, a planetary scientist at Southwest Research Institute in San Antonio, Texas. "This is a stunning discovery for astrobiology." "Whether life could have originated in Enceladus' ocean remains an open question," Glein said.

Science

Synthetic Human Embryos Created In Groundbreaking Device (theguardian.com) 104

An anonymous reader quotes a report from The Guardian: Scientists have created synthetic human embryos using stem cells, in a groundbreaking advance that sidesteps the need for eggs or sperm. Scientists say these model embryos, which resemble those in the earliest stages of human development, could provide a crucial window on the impact of genetic disorders and the biological causes of recurrent miscarriage. However, the work also raises serious ethical and legal issues as the lab-grown entities fall outside current legislation in the UK and most other countries. The structures do not have a beating heart or the beginnings of a brain, but include cells that would typically go on to form the placenta, yolk sac and the embryo itself.

There is no near-term prospect of the synthetic embryos being used clinically. It would be illegal to implant them into a patient's womb, and it is not yet clear whether these structures have the potential to continue maturing beyond the earliest stages of development. The motivation for the work is for scientists to understand the "black box" period of development that is so called because scientists are only allowed to cultivate embryos in the lab up to a legal limit of 14 days. They then pick up the course of development much further along by looking at pregnancy scans and embryos donated for research. The full details of the latest work, from the Cambridge-Caltech lab, are yet to be published in a journal paper. But, speaking at the conference, Zernicka-Goetz described cultivating the embryos to a stage just beyond the equivalent of 14 days of development for a natural embryo.

The model structures, each grown from a single embryonic stem cell, reached the beginning of a developmental milestone known as gastrulation, when the embryo transforms from being a continuous sheet of cells to forming distinct cell lines and setting up the basic axes of the body. At this stage, the embryo does not yet have a beating heart, gut or beginnings of a brain, but the model showed the presence of primordial cells that are the precursor cells of egg and sperm. "Our human model is the first three-lineage human embryo model that specifies amnion and germ cells, precursor cells of egg and sperm," Zernicka-Goetz told the Guardian before the talk. "It's beautiful and created entirely from embryonic stem cells."

Medicine

Google Lens Can Now Search For Skin Conditions 11

Google Lens, the company's computer vision-powered app that scans objects and brings up relevant information, is now able to search for skin conditions, like moles and rashes. "Uploading a picture or photo through Lens will kick off a search for visual matches, which will also work for other physical maladies that you might not be sure how to describe with words (like a bump on the lip, a line on nails or hair loss)," reports TechCrunch. From the report: It's a step short of the AI-driven app Google launched in 2021 to diagnose skin, hair and nail conditions. That app, which debuted first in the E.U., faced barriers to entry in the U.S., where it would have had to have been approved by the Food and Drug Administration. (Google declined to seek approval.) Still, the Lens feature might be useful for folks deciding whether to seek medical attention or over-the-counter treatments. Lens integration with Google Bard is also coming soon. "Users will be able to include images in their Bard prompts and Lens will work behind the scenes to help Bard make sense of what's being shown," reports TechCrunch.

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