Scientists in China successfully transplanted a genetically modified pig liver into a brain-dead patient, where it functioned for 10 days. The liver, modified to reduce immune rejection, produced key proteins and bile, showing compatibility and offering hope for future short-term xenotransplants. The Guardian reports: The surgery, at a Chinese hospital last year, is thought to mark the first time a pig liver has been transplanted into a human. It raises the prospect of pig livers serving as a "bridging organ" for patients on the waiting list for a transplant or to support liver function while their own organ regenerates. [...] The latest procedure was carried out in a 50-year-old man diagnosed with brain death after a severe head injury. The patient's own liver was intact and, in a surgery that took more than 10 hours, the organ taken from a genetically modified Bama miniature pig was plumbed into his blood supply as an additional liver.

The pig had six genetic modifications aimed at preventing immune rejection. These included deactivating genes that contribute to the production of sugars on the surface of pig cells, which the human immune system attacks, and introducing genes that express human proteins to "humanize" the liver. After the transplant, the pig liver showed signs of functioning, including producing bile, which helps break down fats in the digestive system, and porcine albumin, a blood protein. The team behind the advance, described in the journal Nature, said it was not clear whether the liver would have been able to fully support the patient, given that he had an existing liver and because the liver was removed after 10 days at the request of his family.

sciencehabit quotes a report from Science.org: Whales sing, orcas squeal, and sea turtles croak. But sharks are more the strong, silent type. Now, researchers report the first evidence that sharks make sounds, too, described today in Royal Society Open Science. The animals may be making the sounds -- a series of clicking noises -- by snapping their flat rows of teeth, which are blunt for crushing prey. The sharks can hear mostly low-frequency noise, and the clicks they emit are higher pitched, which suggests they are not for communicating with other rigs. It's possible they are a defensive tactic. Marine mammals that eat rigs, such as leopard seals, can hear in the frequency range of the rig clicks, but the researchers question whether a few clicks would deter an attack. The sounds might be part of their response to being startled, the team says.

JPMorgan Chase used a quantum computer from Honeywell's Quantinuum to generate and mathematically certify truly random numbers -- an advancement that could significantly enhance encryption, security, and financial applications. The breakthrough was validated with help from U.S. national laboratories and has been published in the journal Nature. From a report: Between May 2023 and May 2024, cryptographers at JPMorgan wrote an algorithm for a quantum computer to generate random numbers, which they ran on Quantinuum's machine. The US Department of Energy's supercomputers were then used to test whether the output was truly random. "It's a breakthrough result," project lead and Head of Global Technology Applied Research at JPMorgan, Marco Pistoia told Bloomberg in an interview. "The next step will be to understand where we can apply it."

Applications could ultimately include more energy-efficient cryptocurrency, online gambling, and any other activity hinging on complete randomness, such as deciding which precincts to audit in elections.

An anonymous reader quotes a report from Gizmodo: Scientists scrutinizing the seafloor beneath a calving iceberg found a remarkable array of living creatures, switching up notions of how the giant chunks of ice affect their immediate environs. The scientists investigated a region of seafloor recently exposed by the calving of a gigantic iceberg -- A-84 -- which is as large as Chicago. The team found a surprisingly vibrant community of critters on the seafloor below where A-84 was once attached to an ice shelf attached to Antarctica.

Without the 197-square-mile (510-square-kilometer) iceberg in the way, the team was able to scrutinize the seafloor at depths of 4,265 feet (1,300 meters) using the remotely operated vehicle (ROV) SuBastian. The team found large corals and sponges supporting other lifeforms, including icefish, giant sea spiders, and octopus. [...] With the icebergs covering the seafloor, organisms below the shelf cannot get nutrients for survival from the surface. The team hypothesized that ocean currents are a critical driver for life beneath the ice sheets. The team also collected data on the larger ice sheet, whose shrinking size spells concern for the animals that live beneath it.

In an op-ed for MIT Technology Review, authors Carsten T. Charlesworth, Henry T. Greely, and Hiromitsu Nakauchi make the case for human "bodyoids" that could reduce animal testing, improve drug development, and alleviate organ shortages: Why do we hear about medical breakthroughs in mice, but rarely see them translate into cures for human disease? Why do so few drugs that enter clinical trials receive regulatory approval? And why is the waiting list for organ transplantation so long? These challenges stem in large part from a common root cause: a severe shortage of ethically sourced human bodies. It may be disturbing to characterize human bodies in such commodifying terms, but the unavoidable reality is that human biological materials are an essential commodity in medicine, and persistent shortages of these materials create a major bottleneck to progress.

This imbalance between supply and demand is the underlying cause of the organ shortage crisis, with more than 100,000 patients currently waiting for a solid organ transplant in the US alone. It also forces us to rely heavily on animals in medical research, a practice that can't replicate major aspects of human physiology and makes it necessary to inflict harm on sentient creatures. In addition, the safety and efficacy of any experimental drug must still be confirmed in clinical trials on living human bodies. These costly trials risk harm to patients, can take a decade or longer to complete, and make it through to approval less than 15% of the time.

There might be a way to get out of this moral and scientific deadlock. Recent advances in biotechnology now provide a pathway to producing living human bodies without the neural components that allow us to think, be aware, or feel pain. Many will find this possibility disturbing, but if researchers and policymakers can find a way to pull these technologies together, we may one day be able to create "spare" bodies, both human and nonhuman. These could revolutionize medical research and drug development, greatly reducing the need for animal testing, rescuing many people from organ transplant lists, and allowing us to produce more effective drugs and treatments. All without crossing most people's ethical lines.

Although it may seem like science fiction, recent technological progress has pushed this concept into the realm of plausibility. Pluripotent stem cells, one of the earliest cell types to form during development, can give rise to every type of cell in the adult body. Recently, researchers have used these stem cells to create structures that seem to mimic the early development of actual human embryos. At the same time, artificial uterus technology is rapidly advancing, and other pathways may be opening to allow for the development of fetuses outside of the body. Such technologies, together with established genetic techniques to inhibit brain development, make it possible to envision the creation of "bodyoids" -- a potentially unlimited source of human bodies, developed entirely outside of a human body from stem cells, that lack sentience or the ability to feel pain.

Firefly Aerospace has teamed up with Blue Origin's Honeybee Robotics unit to deploy a rover on its 2028 lunar mission to study the Gruithuisen Domes -- rare volcanic formations that may reveal insights into the moon's geology and potential resources. The announcement follows Firefly's successful Blue Ghost Mission 1, which outlasted all prior commercial lunar landings. Reuters reports: The Gruithuisen Domes, located on the moon's near side, are unusual volcanic formations believed to be rich in silica -- a composition rare on the lunar surface -- and studying them could unlock clues about the moon's geological history and potential resources for future human missions. [...] The upcoming mission, part of NASA's Commercial Lunar Payload Services initiative, will use Firefly's Blue Ghost lander and Elytra Dark orbital vehicle, alongside the Honeybee Robotics rover, to explore the domes, building on the success of its debut effort, Firefly said.

NASA's Curiosity rover has detected the largest organic molecules ever found on Mars -- decane, undecane, and dodecane -- suggesting that complex prebiotic chemistry may have occurred in the planet's ancient lakebeds. The findings have been published in the Proceedings of the National Academy of Sciences. From a press release: Scientists probed an existing rock sample inside Curiosity's Sample Analysis at Mars (SAM) mini-lab and found the molecules decane, undecane, and dodecane. These compounds, which are made up of 10, 11, and 12 carbons, respectively, are thought to be the fragments of fatty acids that were preserved in the sample. Fatty acids are among the organic molecules that on Earth are chemical building blocks of life. Living things produce fatty acids to help form cell membranes and perform various other functions. But fatty acids also can be made without life, through chemical reactions triggered by various geological processes, including the interaction of water with minerals in hydrothermal vents.

While there's no way to confirm the source of the molecules identified, finding them at all is exciting for Curiosity's science team for a couple of reasons. Curiosity scientists had previously discovered small, simple organic molecules on Mars, but finding these larger compounds provides the first evidence that organic chemistry advanced toward the kind of complexity required for an origin of life on Mars. The new study also increases the chances that large organic molecules that can be made only in the presence of life, known as "biosignatures," could be preserved on Mars, allaying concerns that such compounds get destroyed after tens of millions of years of exposure to intense radiation and oxidation.

An anonymous reader quotes a report from 404 Media: 23andMe filed for Chapter 11 bankruptcy Sunday, leaving the fate of millions of people's genetic information up in the air as the company deals with the legal and financial fallout of not properly protecting that genetic information in the first place. The filing shows how dangerous it is to provide your DNA directly to a large, for-profit commercial genetic database; 23andMe is now looking for a buyer to pull it out of bankruptcy. 23andMe said in court documents viewed by 404 Media that since hackers obtained personal data about seven million of its customers in October 2023, including, in some cases "health-related information based upon the user's genetics," it has faced "over 50 class action and state court lawsuits," and that "approximately 35,000 claimants have initiated, filed, or threatened to commence arbitration claims against the company." It is seeking bankruptcy protection in part to simplify the fallout of these legal cases, and because it believes it may not have money to pay for the potential damages associated with these cases.

CEO and cofounder Anne Wojcicki announced she is leaving the company as part of this process. The company has the genetic data of more than 15 million customers. According to its Chapter 11 filing, 23andMe owes money to a host of pharmaceutical companies, pharmacies, artificial intelligence companies (including a company called Aganitha AI and Coreweave), as well as health insurance companies and marketing companies. Shortly before the filing, California Attorney General Rob Bonta issued an "urgent" alert to 23andMe customers: "Given 23andMe's reported financial distress, I remind Californians to consider invoking their rights and directing 23andMe to delete their data and destroy any samples of genetic material held by the company."

In a letter to customers Sunday, 23andMe said: "Your data remains protected. The Chapter 11 filing does not change how we store, manage, or protect customer data. Our users' privacy and data are important considerations in any transaction, and we remain committed to our users' privacy and to being transparent with our customers about how their data is managed." It added that any buyer will have to "comply with applicable law with respect to the treatment of customer data."

404 Media's Jason Koebler notes that "there's no way of knowing who is going to buy it, why they will be interested, and what will become of its millions of customers' DNA sequences. 23andMe has claimed over the years that it strongly resists law enforcement requests for information and that it takes customer security seriously. But the company has in recent years changed its terms of service, partnered with big pharmaceutical companies, and, of course, was hacked."

CERN faces a pivotal decision about its future as the Large Hadron Collider approaches the end of its usefulness by the early 2040s. Management proposes building the Future Circular Collider (FCC), a machine with a 90-kilometer circumference that would smash particles at eight times the energy of the LHC. This hugely consequential plan faces significant challenges. Much of the required technology doesn't exist yet, including superconducting magnets strong enough to bend high-energy particle beams.

The project also lacks the clear rationale that the LHC had in finding the Higgs boson. The proposal has divided physicists. Critics worry about the decades-long timeline, potential cost overruns, and the risk of sacrificing other valuable CERN activities. Germany, which provides 20% of the lab's budget, has already indicated it won't increase contributions. A council-appointed group is now gathering input from the physics community before making recommendations in December.

Nature's editorial board adds: Unless some nations step up with a major infusion of cash, the FCC faces an uncertain prospect of being funded. But waiting too long could mean that there will be a large gap between the new facility opening and the closure of the LHC, and precious expertise could end up being lost.

Although physicists might disagree on what CERN should do, they nearly unanimously care about the lab's future. They and their leaders must now make the case for why European taxpayers, who fund most of the lab's yearly budget should care, too. The stakes are beyond science, and even beyond Europe.

Scientists are developing biomarkers to objectively measure pain, addressing a fundamental medical challenge that has contributed to the opioid crisis and led to consistent underestimation of pain in women and minorities.

Four research teams funded by the Department of Health and Human Services are developing technologies to quantify pain like other vital signs. Their approaches include a blood test for endometriosis pain, a device measuring nerve response through pupil dilation, microneedle patches sampling interstitial fluid, and a wearable sensor detecting pain markers in sweat.

"When patients are told that the pain is all in their head, the implication is that it's imagined, but the irony is that's sort of right," said Adam Kepecs, a neuroscience professor at Washington University. "The pain only exists in your brain. It's neural activity, which is why it's invisible and uniquely personal. But it's still real." These innovations could transform treatment for the nearly 25% of Americans suffering from chronic pain, while potentially saving billions in healthcare costs.

RockDoctor (Slashdot reader #15,477) writes: A recent paper on ArXiv reports a novel idea about the central regions of "our" galaxy.

Remember the hoopla a few years ago about radio-astronomical observations producing an "image" of our central black hole — or rather, an image of the accretion disc around the black hole — long designated by astronomers as "Sagittarius A*" (or SGR-A*)? If you remember the image published then, one thing should be striking — it's not very symmetrical. If you think about viewing a spinning object, then you'd expect to see something with a "mirror" symmetry plane where we would see the rotation axis (if someone had marked it). If anything, that published image has three bright spots on a fainter ring. And the spots are not even approximately the same brightness.

This paper suggests that the image we see is the result of the light (radio waves) from SGR-A* being "lensed" by another black hole, near (but not quite on) the line of sight between SGR-A* and us. By various modelling approaches, they then refine this idea to a "best-fit" of a black hole with mass around 1000 times the Sun, orbiting between the distance of the closest-observed star to SGR-A* ("S2" — most imaginative name, ever!), and around 10 times that distance. That's far enough to make a strong interaction with "S2" unlikely within the lifetime of S2 before it's accretion onto SGR-A*.)

The region around SGR-A* is crowded. Within 25 parsecs (~80 light years, the distance to Regulus [in the constellation Leo] or Merak [in the Great Bear]) there is around 4 times more mass in several millions of "normal" stars than in the SGR-A* black hole. Finding a large (not "super massive") black hole in such a concentration of matter shouldn't surprise anyone.

This proposed black hole is larger than anything which has been detected by gravitational waves (yet) ; but not immensely larger — only a factor of 15 or so. (The authors also anticipate the "what about these big black holes spiralling together?" question : quote "and the amplitude of gravitational waves generated by the binary black holes is negligible.")

Being so close to SGR-A*, the proposed black hole is likely to be moving rapidly across our line of sight. At the distance of "S2" it's orbital period would be around 26 years (but the "new" black hole is probably further out than than that). Which might be an explanation for some of the variability and "flickering" reported for SGR-A* ever since it's discovery.

As always, more observations are needed. Which, for SGR-A* are frequently being taken, so improving (or ruling out) this explanation should happen fairly quickly. But it's a very interesting, and fun, idea.

NPR reports on research "into whether our defenses built up from past flu seasons can offer any protection against H5N1 bird flu." So far, the findings offer some reassurance. Antibodies and other players in the immune system may buffer the worst consequences of bird flu, at least to some degree. "There's certainly preexisting immunity," says Florian Krammer, a virologist at Mount Sinai's Icahn School of Medicine who is involved in some of the new studies. "That's very likely not going to protect us as a population from a new pandemic, but it might give us some protection against severe disease." This protection is based on shared traits between bird flu and types of seasonal flu that have circulated among us. Certain segments of the population, namely older people, may be particularly well-primed because of flu infections during early childhood.

Of course, there are caveats. "While this is a bit of a silver lining, it doesn't mean we should all feel safe," says Seema Lakdawala, a virologist at Emory University's School of Medicine whose lab is probing this question. For one thing, the studies can't be done on people. The conclusions are based on animal models and blood tests that measure the immune response. And how this holds up for an individual is expected to vary considerably, depending on their own immune history, underlying health conditions and other factors. But for now, influenza researchers speculate this may be one reason most people who've caught bird flu over the past year have not fallen severely ill....

Research published this month is encouraging. By analyzing blood samples from close to 160 people, a team at the University of Pennsylvania and the University of Chicago were able to show that people born roughly before 1965 had higher levels of antibodies — proteins that bind to parts of the virus — which cross-react to the current strain of bird flu.
This week U.S. federal officials also "announced funding for avian influenza research projects, including money for new vaccine projects and potential treatments," the Guardian report. The head of America's agriculture department said it would invest $100 million, as part of a larger $1 billion initiative to fight bird flu and stop rising egg prices, according to the nonprofit news site Iowa Capital Dispatch.

Science magazine reports: A strange-looking telescope that scanned the skies from a perch in northern Chile for 15 years has released its final data set: detailed maps of the infant universe showing the roiling clouds of hydrogen and helium gas that would one day coalesce into the stars and galaxies we see today.

The Atacama Cosmology Telescope is not the first to survey the cosmic microwave background (CMB), the light released 380,000 years after the Big Bang when the early universe's soup of particles formed atoms and space became transparent. But the data — posted as preprints online today — give researchers a new level of detail on the density of the gas clouds and how they were moving.
At the top of the page for Science's article is an image where different colors "show areas where the polarization of the CMB light — its direction of vibration — differ, revealing how gases first move tangentially around areas of higher density (orange) and later fall straight in (blue) under the influence of gravity."

Long-time Slashdot reader sciencehabit writes: Using the data, researchers tested how well the standard cosmological theory, known as lambda cold dark matter, described the universe at that time 13.8 billion years ago; it's a remarkably good fit, they conclude.
The article notes that "back in the Chilean desert," the Atacama Cosmology Telescope's successor, the Simons Observatory, has already taken its first image, and "will begin its even more detailed examination of the CMB in the coming months."

NASA is considering "closing its headquarters and scattering responsibilities among the states," reports Politico, citing two people familiar with the plan. "The proposal could affect up to 2,500 jobs and redistribute critical functions, including who manages space exploration and organizes major science missions." While much of the day-to-day work occurs at NASA's 10 centers, the Washington office plays a strategic role in lobbying for the agency's priorities in Congress, ensuring the White House supports its agenda and partnering with foreign countries on critical space projects. Some of the headquarter's offices might remain in Washington, the people said, but it's not clear which ones those would be or who would keep their jobs...

One of the biggest fallouts is the damage it could do to coordination among NASA leadership on pressing issues... It would also limit cooperation with international partners on space, which is often done through embassies in Washington. NASA works with foreign partners on a range of projects, including the International Space Station and returning to the moon. The European Space Agency, for example, plans to provide modules for Gateway, a lunar space station that is central to NASA's Artemis program to land American astronauts back on the moon... The agency also helps coordinate support from foreign nations for the Artemis accords, which set goals for transparency and data sharing — and help create a level of trust in an unregulated part of the universe.

But the reallocation could have some benefits. Such a move would bring headquarters employees closer to the processes they manage. And it would give legislative liaison staff a chance to interact with lawmakers in their districts. "You're probably getting a lot more time with [lawmakers] at the local center or hosting events in the state or district," said Tom Culligan, a longtime space lobbyist,, the space industry lobbyist.

Slashdot reader Required Snark shared this article from Phys.org: In the realm of science fiction, [sun-energy capturing] Dyson spheres and ringworlds have been staples for decades. But it is well known that the simplest designs are unstable against gravitational forces and would thus be torn apart. Now a scientist from Scotland, UK has shown that certain configurations of these objects near a two-mass system can be stable against such fractures...

[A] rigid ring around a star or planet, as in Larry Niven's "Ringworld" series of novels, is also unstable, as it would drift under any slight gravitational differences and collide with the star. So [engineering science professor Colin] McInnes considered a restricted three-body problem where two equal masses orbit each other circularly with a uniform ring of infinitesimal mass rotating in their orbital plane. The ring could enclose both masses, just one or none... McInnes also investigated a shell-restricted three-body problem with the shell also of infinitesimal mass, again with the shell enclosing two masses, one or none.

For the restricted ring, McInnes found that there are seven equilibrium points in the orbital plane of the dual masses, on which, if the ring's center were placed, it would stay and not experience stresses, akin to the three stable Lagrange points where a small mass can reside permanently for the two-body problem... McInnes restricted this research to a planar ring (in the plane of the circularly orbiting masses) but says it can be shown that a vertical ring, normal to the plane, can also generate equilibria...

These results can aid the search for extraterrestrial intelligence, McInnes said, "If we can understand when such structures can be stable, then this could potentially help direct future SETI surveys." An important technosignature would be one bright star orbiting in tandem with an object showing a strong infrared excess. Shells around a sun-exoplanet pair or an exoplanet-exoplanet pair could also be possible. A nested set of Dyson spheres is also a feasible geometry.
In 2003 Ringworld author Larry Niven answered questions from Slashdot readers...