In an op-ed for MIT Technology Review, authors Carsten T. Charlesworth, Henry T. Greely, and Hiromitsu Nakauchi make the case for human "bodyoids" that could reduce animal testing, improve drug development, and alleviate organ shortages: Why do we hear about medical breakthroughs in mice, but rarely see them translate into cures for human disease? Why do so few drugs that enter clinical trials receive regulatory approval? And why is the waiting list for organ transplantation so long? These challenges stem in large part from a common root cause: a severe shortage of ethically sourced human bodies. It may be disturbing to characterize human bodies in such commodifying terms, but the unavoidable reality is that human biological materials are an essential commodity in medicine, and persistent shortages of these materials create a major bottleneck to progress.

This imbalance between supply and demand is the underlying cause of the organ shortage crisis, with more than 100,000 patients currently waiting for a solid organ transplant in the US alone. It also forces us to rely heavily on animals in medical research, a practice that can't replicate major aspects of human physiology and makes it necessary to inflict harm on sentient creatures. In addition, the safety and efficacy of any experimental drug must still be confirmed in clinical trials on living human bodies. These costly trials risk harm to patients, can take a decade or longer to complete, and make it through to approval less than 15% of the time.

There might be a way to get out of this moral and scientific deadlock. Recent advances in biotechnology now provide a pathway to producing living human bodies without the neural components that allow us to think, be aware, or feel pain. Many will find this possibility disturbing, but if researchers and policymakers can find a way to pull these technologies together, we may one day be able to create "spare" bodies, both human and nonhuman. These could revolutionize medical research and drug development, greatly reducing the need for animal testing, rescuing many people from organ transplant lists, and allowing us to produce more effective drugs and treatments. All without crossing most people's ethical lines.

Although it may seem like science fiction, recent technological progress has pushed this concept into the realm of plausibility. Pluripotent stem cells, one of the earliest cell types to form during development, can give rise to every type of cell in the adult body. Recently, researchers have used these stem cells to create structures that seem to mimic the early development of actual human embryos. At the same time, artificial uterus technology is rapidly advancing, and other pathways may be opening to allow for the development of fetuses outside of the body. Such technologies, together with established genetic techniques to inhibit brain development, make it possible to envision the creation of "bodyoids" -- a potentially unlimited source of human bodies, developed entirely outside of a human body from stem cells, that lack sentience or the ability to feel pain.

Firefly Aerospace has teamed up with Blue Origin's Honeybee Robotics unit to deploy a rover on its 2028 lunar mission to study the Gruithuisen Domes -- rare volcanic formations that may reveal insights into the moon's geology and potential resources. The announcement follows Firefly's successful Blue Ghost Mission 1, which outlasted all prior commercial lunar landings. Reuters reports: The Gruithuisen Domes, located on the moon's near side, are unusual volcanic formations believed to be rich in silica -- a composition rare on the lunar surface -- and studying them could unlock clues about the moon's geological history and potential resources for future human missions. [...] The upcoming mission, part of NASA's Commercial Lunar Payload Services initiative, will use Firefly's Blue Ghost lander and Elytra Dark orbital vehicle, alongside the Honeybee Robotics rover, to explore the domes, building on the success of its debut effort, Firefly said.

NASA's Curiosity rover has detected the largest organic molecules ever found on Mars -- decane, undecane, and dodecane -- suggesting that complex prebiotic chemistry may have occurred in the planet's ancient lakebeds. The findings have been published in the Proceedings of the National Academy of Sciences. From a press release: Scientists probed an existing rock sample inside Curiosity's Sample Analysis at Mars (SAM) mini-lab and found the molecules decane, undecane, and dodecane. These compounds, which are made up of 10, 11, and 12 carbons, respectively, are thought to be the fragments of fatty acids that were preserved in the sample. Fatty acids are among the organic molecules that on Earth are chemical building blocks of life. Living things produce fatty acids to help form cell membranes and perform various other functions. But fatty acids also can be made without life, through chemical reactions triggered by various geological processes, including the interaction of water with minerals in hydrothermal vents.

While there's no way to confirm the source of the molecules identified, finding them at all is exciting for Curiosity's science team for a couple of reasons. Curiosity scientists had previously discovered small, simple organic molecules on Mars, but finding these larger compounds provides the first evidence that organic chemistry advanced toward the kind of complexity required for an origin of life on Mars. The new study also increases the chances that large organic molecules that can be made only in the presence of life, known as "biosignatures," could be preserved on Mars, allaying concerns that such compounds get destroyed after tens of millions of years of exposure to intense radiation and oxidation.

An anonymous reader quotes a report from 404 Media: 23andMe filed for Chapter 11 bankruptcy Sunday, leaving the fate of millions of people's genetic information up in the air as the company deals with the legal and financial fallout of not properly protecting that genetic information in the first place. The filing shows how dangerous it is to provide your DNA directly to a large, for-profit commercial genetic database; 23andMe is now looking for a buyer to pull it out of bankruptcy. 23andMe said in court documents viewed by 404 Media that since hackers obtained personal data about seven million of its customers in October 2023, including, in some cases "health-related information based upon the user's genetics," it has faced "over 50 class action and state court lawsuits," and that "approximately 35,000 claimants have initiated, filed, or threatened to commence arbitration claims against the company." It is seeking bankruptcy protection in part to simplify the fallout of these legal cases, and because it believes it may not have money to pay for the potential damages associated with these cases.

CEO and cofounder Anne Wojcicki announced she is leaving the company as part of this process. The company has the genetic data of more than 15 million customers. According to its Chapter 11 filing, 23andMe owes money to a host of pharmaceutical companies, pharmacies, artificial intelligence companies (including a company called Aganitha AI and Coreweave), as well as health insurance companies and marketing companies. Shortly before the filing, California Attorney General Rob Bonta issued an "urgent" alert to 23andMe customers: "Given 23andMe's reported financial distress, I remind Californians to consider invoking their rights and directing 23andMe to delete their data and destroy any samples of genetic material held by the company."

In a letter to customers Sunday, 23andMe said: "Your data remains protected. The Chapter 11 filing does not change how we store, manage, or protect customer data. Our users' privacy and data are important considerations in any transaction, and we remain committed to our users' privacy and to being transparent with our customers about how their data is managed." It added that any buyer will have to "comply with applicable law with respect to the treatment of customer data."

404 Media's Jason Koebler notes that "there's no way of knowing who is going to buy it, why they will be interested, and what will become of its millions of customers' DNA sequences. 23andMe has claimed over the years that it strongly resists law enforcement requests for information and that it takes customer security seriously. But the company has in recent years changed its terms of service, partnered with big pharmaceutical companies, and, of course, was hacked."

CERN faces a pivotal decision about its future as the Large Hadron Collider approaches the end of its usefulness by the early 2040s. Management proposes building the Future Circular Collider (FCC), a machine with a 90-kilometer circumference that would smash particles at eight times the energy of the LHC. This hugely consequential plan faces significant challenges. Much of the required technology doesn't exist yet, including superconducting magnets strong enough to bend high-energy particle beams.

The project also lacks the clear rationale that the LHC had in finding the Higgs boson. The proposal has divided physicists. Critics worry about the decades-long timeline, potential cost overruns, and the risk of sacrificing other valuable CERN activities. Germany, which provides 20% of the lab's budget, has already indicated it won't increase contributions. A council-appointed group is now gathering input from the physics community before making recommendations in December.

Nature's editorial board adds: Unless some nations step up with a major infusion of cash, the FCC faces an uncertain prospect of being funded. But waiting too long could mean that there will be a large gap between the new facility opening and the closure of the LHC, and precious expertise could end up being lost.

Although physicists might disagree on what CERN should do, they nearly unanimously care about the lab's future. They and their leaders must now make the case for why European taxpayers, who fund most of the lab's yearly budget should care, too. The stakes are beyond science, and even beyond Europe.

Scientists are developing biomarkers to objectively measure pain, addressing a fundamental medical challenge that has contributed to the opioid crisis and led to consistent underestimation of pain in women and minorities.

Four research teams funded by the Department of Health and Human Services are developing technologies to quantify pain like other vital signs. Their approaches include a blood test for endometriosis pain, a device measuring nerve response through pupil dilation, microneedle patches sampling interstitial fluid, and a wearable sensor detecting pain markers in sweat.

"When patients are told that the pain is all in their head, the implication is that it's imagined, but the irony is that's sort of right," said Adam Kepecs, a neuroscience professor at Washington University. "The pain only exists in your brain. It's neural activity, which is why it's invisible and uniquely personal. But it's still real." These innovations could transform treatment for the nearly 25% of Americans suffering from chronic pain, while potentially saving billions in healthcare costs.

RockDoctor (Slashdot reader #15,477) writes: A recent paper on ArXiv reports a novel idea about the central regions of "our" galaxy.

Remember the hoopla a few years ago about radio-astronomical observations producing an "image" of our central black hole — or rather, an image of the accretion disc around the black hole — long designated by astronomers as "Sagittarius A*" (or SGR-A*)? If you remember the image published then, one thing should be striking — it's not very symmetrical. If you think about viewing a spinning object, then you'd expect to see something with a "mirror" symmetry plane where we would see the rotation axis (if someone had marked it). If anything, that published image has three bright spots on a fainter ring. And the spots are not even approximately the same brightness.

This paper suggests that the image we see is the result of the light (radio waves) from SGR-A* being "lensed" by another black hole, near (but not quite on) the line of sight between SGR-A* and us. By various modelling approaches, they then refine this idea to a "best-fit" of a black hole with mass around 1000 times the Sun, orbiting between the distance of the closest-observed star to SGR-A* ("S2" — most imaginative name, ever!), and around 10 times that distance. That's far enough to make a strong interaction with "S2" unlikely within the lifetime of S2 before it's accretion onto SGR-A*.)

The region around SGR-A* is crowded. Within 25 parsecs (~80 light years, the distance to Regulus [in the constellation Leo] or Merak [in the Great Bear]) there is around 4 times more mass in several millions of "normal" stars than in the SGR-A* black hole. Finding a large (not "super massive") black hole in such a concentration of matter shouldn't surprise anyone.

This proposed black hole is larger than anything which has been detected by gravitational waves (yet) ; but not immensely larger — only a factor of 15 or so. (The authors also anticipate the "what about these big black holes spiralling together?" question : quote "and the amplitude of gravitational waves generated by the binary black holes is negligible.")

Being so close to SGR-A*, the proposed black hole is likely to be moving rapidly across our line of sight. At the distance of "S2" it's orbital period would be around 26 years (but the "new" black hole is probably further out than than that). Which might be an explanation for some of the variability and "flickering" reported for SGR-A* ever since it's discovery.

As always, more observations are needed. Which, for SGR-A* are frequently being taken, so improving (or ruling out) this explanation should happen fairly quickly. But it's a very interesting, and fun, idea.

NPR reports on research "into whether our defenses built up from past flu seasons can offer any protection against H5N1 bird flu." So far, the findings offer some reassurance. Antibodies and other players in the immune system may buffer the worst consequences of bird flu, at least to some degree. "There's certainly preexisting immunity," says Florian Krammer, a virologist at Mount Sinai's Icahn School of Medicine who is involved in some of the new studies. "That's very likely not going to protect us as a population from a new pandemic, but it might give us some protection against severe disease." This protection is based on shared traits between bird flu and types of seasonal flu that have circulated among us. Certain segments of the population, namely older people, may be particularly well-primed because of flu infections during early childhood.

Of course, there are caveats. "While this is a bit of a silver lining, it doesn't mean we should all feel safe," says Seema Lakdawala, a virologist at Emory University's School of Medicine whose lab is probing this question. For one thing, the studies can't be done on people. The conclusions are based on animal models and blood tests that measure the immune response. And how this holds up for an individual is expected to vary considerably, depending on their own immune history, underlying health conditions and other factors. But for now, influenza researchers speculate this may be one reason most people who've caught bird flu over the past year have not fallen severely ill....

Research published this month is encouraging. By analyzing blood samples from close to 160 people, a team at the University of Pennsylvania and the University of Chicago were able to show that people born roughly before 1965 had higher levels of antibodies — proteins that bind to parts of the virus — which cross-react to the current strain of bird flu.
This week U.S. federal officials also "announced funding for avian influenza research projects, including money for new vaccine projects and potential treatments," the Guardian report. The head of America's agriculture department said it would invest $100 million, as part of a larger $1 billion initiative to fight bird flu and stop rising egg prices, according to the nonprofit news site Iowa Capital Dispatch.

Science magazine reports: A strange-looking telescope that scanned the skies from a perch in northern Chile for 15 years has released its final data set: detailed maps of the infant universe showing the roiling clouds of hydrogen and helium gas that would one day coalesce into the stars and galaxies we see today.

The Atacama Cosmology Telescope is not the first to survey the cosmic microwave background (CMB), the light released 380,000 years after the Big Bang when the early universe's soup of particles formed atoms and space became transparent. But the data — posted as preprints online today — give researchers a new level of detail on the density of the gas clouds and how they were moving.
At the top of the page for Science's article is an image where different colors "show areas where the polarization of the CMB light — its direction of vibration — differ, revealing how gases first move tangentially around areas of higher density (orange) and later fall straight in (blue) under the influence of gravity."

Long-time Slashdot reader sciencehabit writes: Using the data, researchers tested how well the standard cosmological theory, known as lambda cold dark matter, described the universe at that time 13.8 billion years ago; it's a remarkably good fit, they conclude.
The article notes that "back in the Chilean desert," the Atacama Cosmology Telescope's successor, the Simons Observatory, has already taken its first image, and "will begin its even more detailed examination of the CMB in the coming months."

NASA is considering "closing its headquarters and scattering responsibilities among the states," reports Politico, citing two people familiar with the plan. "The proposal could affect up to 2,500 jobs and redistribute critical functions, including who manages space exploration and organizes major science missions." While much of the day-to-day work occurs at NASA's 10 centers, the Washington office plays a strategic role in lobbying for the agency's priorities in Congress, ensuring the White House supports its agenda and partnering with foreign countries on critical space projects. Some of the headquarter's offices might remain in Washington, the people said, but it's not clear which ones those would be or who would keep their jobs...

One of the biggest fallouts is the damage it could do to coordination among NASA leadership on pressing issues... It would also limit cooperation with international partners on space, which is often done through embassies in Washington. NASA works with foreign partners on a range of projects, including the International Space Station and returning to the moon. The European Space Agency, for example, plans to provide modules for Gateway, a lunar space station that is central to NASA's Artemis program to land American astronauts back on the moon... The agency also helps coordinate support from foreign nations for the Artemis accords, which set goals for transparency and data sharing — and help create a level of trust in an unregulated part of the universe.

But the reallocation could have some benefits. Such a move would bring headquarters employees closer to the processes they manage. And it would give legislative liaison staff a chance to interact with lawmakers in their districts. "You're probably getting a lot more time with [lawmakers] at the local center or hosting events in the state or district," said Tom Culligan, a longtime space lobbyist,, the space industry lobbyist.

Slashdot reader Required Snark shared this article from Phys.org: In the realm of science fiction, [sun-energy capturing] Dyson spheres and ringworlds have been staples for decades. But it is well known that the simplest designs are unstable against gravitational forces and would thus be torn apart. Now a scientist from Scotland, UK has shown that certain configurations of these objects near a two-mass system can be stable against such fractures...

[A] rigid ring around a star or planet, as in Larry Niven's "Ringworld" series of novels, is also unstable, as it would drift under any slight gravitational differences and collide with the star. So [engineering science professor Colin] McInnes considered a restricted three-body problem where two equal masses orbit each other circularly with a uniform ring of infinitesimal mass rotating in their orbital plane. The ring could enclose both masses, just one or none... McInnes also investigated a shell-restricted three-body problem with the shell also of infinitesimal mass, again with the shell enclosing two masses, one or none.

For the restricted ring, McInnes found that there are seven equilibrium points in the orbital plane of the dual masses, on which, if the ring's center were placed, it would stay and not experience stresses, akin to the three stable Lagrange points where a small mass can reside permanently for the two-body problem... McInnes restricted this research to a planar ring (in the plane of the circularly orbiting masses) but says it can be shown that a vertical ring, normal to the plane, can also generate equilibria...

These results can aid the search for extraterrestrial intelligence, McInnes said, "If we can understand when such structures can be stable, then this could potentially help direct future SETI surveys." An important technosignature would be one bright star orbiting in tandem with an object showing a strong infrared excess. Shells around a sun-exoplanet pair or an exoplanet-exoplanet pair could also be possible. A nested set of Dyson spheres is also a feasible geometry.
In 2003 Ringworld author Larry Niven answered questions from Slashdot readers...

Cosmologists have uncovered stronger evidence that dark energy -- the mysterious force accelerating cosmic expansion -- may be weakening over time. The Dark Energy Spectroscopic Instrument (DESI) collaboration presented their latest findings at the Global Physics Summit in Anaheim, California, reinforcing their preliminary results from last year.

The DESI team analyzed data from approximately 15 million galaxies collected over three years, more than doubling their previous dataset of 6 million galaxies. Combined with supernova observations and cosmic microwave background data, their analysis shows a 4.2-sigma deviation from the standard Lambda-CDM cosmological model, which assumes dark energy remains constant.

"We are much more certain than last year that this is definitely a thing," said Seshadri Nadathur of the University of Portsmouth, a key DESI researcher. These findings align with recent independent results from the Dark Energy Survey (DES), which earlier this month reported a similar 3.2-sigma tension with Lambda-CDM -- a tension that disappears if dark energy is allowed to vary. If confirmed, evolving dark energy could fundamentally alter cosmologists' understanding of the universe's ultimate fate. Instead of expanding indefinitely until all particles become impossibly separated, the universe might follow alternative trajectories.

"It challenges the fate of the universe," explained Mustapha Ishak-Boushaki from the University of Texas at Dallas. "It's game-changing." Moreover, these findings challenge the simplest explanation of dark energy as vacuum energy, which quantum physics suggests should remain constant. Instead, the results indicate unknown physics, possibly involving a new particle, a modification to Einstein's theory of gravity, or even a new fundamental theory. DESI will continue observing through 2026, eventually producing a final map expected to include 50 million galaxies, potentially providing definitive evidence for this cosmic paradigm shift.

An anonymous reader quotes a report from Ars Technica: [A] team of Korean researchers [describe] how they've engineered a bacterial strain that can make a useful polymer starting with nothing but glucose as fuel. The system they developed is based on an enzyme that the bacteria use when they're facing unusual nutritional conditions, and it can be tweaked to make a wide range of polymers. The researchers focused on the system bacterial cells use for producing polyhydroxyalkanoates (PHAs). These chemicals are formed when the bacterial cells continue to have a good supply of carbon sources and energy, but they lack some other key nutrients needed to grow and divide. Under these circumstances, the cell will link together small molecules that contain a handful of carbons, forming a much larger polymer. When nutritional conditions improve, the cell can simply break down the polymer and use the individual molecules it contained.

The striking thing about this system is that it's not especially picky about the identity of the molecules it links into the polymer. So far, over 150 different small molecules have been found incorporated into PHAs. It appears that the enzyme that makes the polymer, PHA synthase, only cares about two things: whether the molecule can form an ester bond (PHAs are polyesters), and whether it can be linked to a molecule that's commonly used as an intermediate in the cell's biochemistry, Coenzyme A. Normally, PHA synthase forms links between molecules that run through an oxygen atom. But it's also possible to form a related chemical link that instead runs through a nitrogen atom, like those found on amino acids. There were no known enzymes, however, that catalyze these reactions. So, the researchers decided to test whether any existing enzymes could be induced to do something they don't normally do. [...]

Overall, the system they develop is remarkably flexible, able to incorporate a huge range of chemicals into a polymer. This should allow them to tune the resulting plastic across a wide range of properties. And, considering the bonds were formed via enzyme, the resulting polymer will almost certainly be biodegradable. There are, however, some negatives. The process doesn't allow complete control over what gets incorporated into the polymer. You can bias it toward a specific mix of amino acids or other chemicals, but you can't entirely stop the enzyme from incorporating random chemicals from the cell's metabolism into the polymer at some level. There's also the issue of purifying the polymer from all the rest of the cell components before incorporating it into manufacturing. Production is also relatively slow compared to large-scale industrial production. The findings have been published in the journal Nature Chemical Biology.

NASA's SpaceX Crew-9 has returned to Earth safely after a stay of more than nine months aboard the International Space Station. The crew remained in space longer than expected due to issues with Boeing's Starliner capsule, which was originally scheduled to bring them home sooner.

While the mission has been politically fraught, the astronauts said in a rare space-to-earth interview last month that they were neither stranded nor abandoned. "That's been the rhetoric. That's been the narrative from day one: stranded, abandoned, stuck -- and I get it. We both get it," [NASA astronaut Butch] Wilmore said. "But that is, again, not what our human spaceflight program is about. We don't feel abandoned, we don't feel stuck, we don't feel stranded." Wilmore added a request: "If you'll help us change the rhetoric, help us change the narrative. Let's change it to 'prepared and committed.' That's what we prefer..." CNN has more details on the arrival: Williams and Wilmore, alongside NASA's Nick Hague and cosmonaut Aleksandr Gorbunov of Russia's Roscosmos space agency, safely splashed down off the coast of Tallahassee, Florida at 5:57 p.m. ET. The crew's highly anticipated return came after the crew climbed aboard a SpaceX Crew Dragon capsule and departed the International Space Station at 1:05 a.m. ET. Williams, Wilmore, Hague and Gorbunov spent Tuesday morning and afternoon in orbit in the roughly 13-foot-wide (4-meter-wide), gumdrop-shaped SpaceX Crew Dragon spacecraft. Gradually descending, the capsule carried the astronauts from the space station, which orbits about 250 miles (400 kilometers) above Earth, toward the thick inner layer of our planet's atmosphere.

Around 5 p.m. ET, the Crew Dragon capsule began firing its engines to begin the final phase of the journey: reentry. This leg of the journey is considered the most dangerous of any flight home from space. The jarring physics of hitting the atmosphere while traveling more than 22 times the speed of sound routinely heats the exterior of returning spacecraft to more than 3,500 degrees Fahrenheit (1,926 degrees Celsius) and can trigger a communication blackout. After plunging toward home, the Crew Dragon spacecraft deployed two sets of parachutes in quick succession to further slow its descent. The capsule decelerated from orbital speeds of more than 17,000 miles per hour (27,359 kilometers per hour) to less than 20 miles per hour (32 kilometers per hour) as the vehicle hit the ocean.

After the vehicle hit the ocean, a SpaceX rescue ship waiting nearby worked to haul the spacecraft out of the water. Williams and Wilmore and their crewmates will soon exit Dragon and take their first breaths of earthly air in nine months. Medical teams will evaluate the crew's health, as is routine after astronauts return from space, before deciding next steps. Ultimately, the NASA crew members will return to their home base at Johnson Space Center in Houston. You can watch a recording of the re-entry and splashdown here.

A newly FDA-approved form of adaptive deep-brain stimulation (DBS) for Parkinson's disease adjusts electrical stimulation in real time based on an individual's brain signals, improving symptom control and reducing medication dependence. Scientific American: For decades, Keith Krehbiel took high doses of medications with a debilitating side effect -- severe nausea -- following his diagnosis with early-onset Parkinson's disease at age 42 in 1997. When each dose wore off, he experienced dyskinesia -- involuntary, repetitive muscle movements. In his case, this consisted of head bobbing and weaving. Krehbiel is among one million Americans who live with this progressive neurological disorder, which causes slowed movements, tremors and balance problems. But soon after surgery to implant electrodes into specific areas of his brain in 2020, his life dramatically improved. "My tremor went away almost entirely," says Krehbiel, now age 70 and a professor emeritus of political science at the Stanford Graduate School of Business, whose Parkinson's symptoms began at age 40 and were initially misdiagnosed as repetitive stress injury from computer use. "I reduced my Parkinson's meds by more than two thirds," he adds. "And I no longer have a sensation of a foggy brain, nor nausea or dyskinesia."

Krehbiel was the first participant to enroll in a clinical trial testing a new form of deep-brain stimulation (DBS), a technology that gained approval from the U.S. Food and Drug Administration for Parkinson's tremor and essential tremor in 1997 (it was later approved for other symptoms and conditions). The new adaptive system adjusts stimulation levels automatically based on the person's individual brain signals. In late February it received FDA approval for Parkinson's disease "based on results of the international multicenter trial, which involved participants at 10 sites across a total of four countries -- the U.S., the Netherlands, Canada and France. This technology is suitable for anyone with Parkinson's, not just individuals in clinical trials, says Helen Bronte-Stewart, the recent trial's global lead investigator and a neurologist specializing in movement disorders at Stanford Medicine. "Like a cardiac pacemaker that responds to the rhythms of the heart, adaptive deep-brain stimulation uses a person's individual brain signals to control the electric pulses it delivers," Bronte-Stewart says. "This makes it more personalized, precise and efficient than older DBS methods."

"Traditional DBS delivers constant stimulation, which doesn't always match the fluctuating symptoms of Parkinson's disease," adds neurologist Todd Herrington, another of the trial's investigators and director of the deep-brain stimulation program at Massachusetts General Hospital. With adaptive DBS, "the goal is to adjust stimulation in real time to provide more effective symptom control, fewer side effects and improved patient quality of life." Current FDA approval of this adaptive system is for the treatment of Parkinson's only, not essential tremor, dystonia (a neurological disorder that causes excessive, repetitive and involuntary muscle contractions) or epilepsy, which still rely on traditional, continuous DBS, Herrington says.

Across high-income countries, humans' ability to reason and solve problems appears to have peaked in the early 2010s and declined since. Despite no changes in fundamental brain biology, test scores for both teenagers and adults show deteriorating performance in reading, mathematics and science. In an eye-opening statistic, 25% of adults in high-income countries now struggle to "use mathematical reasoning when reviewing statements" -- rising to 35% in the US.

This cognitive decline coincides with a fundamental shift in our relationship with information. Americans reading books has fallen below 50%, while difficulty thinking and concentrating among 18-year-olds has climbed sharply since the mid-2010s. The timing points to our changing digital habits: a transition from finite web pages to infinite feeds, from active browsing to passive consumption, and from focused attention to constant context-switching.

Research shows that intentional use of digital technologies can be beneficial, but the passive consumption dominating recent years impairs verbal processing, attention, working memory and self-regulation.

Some of the cited research in the story:
New PIAAC results show declining literacy and increasing inequality in many European countries â" Better adult learning is necessary;
Have attention spans been declining?;
Short- and long-term effects of passive and active screen time on young children's phonological memory;
Efficient, helpful, or distracting? A literature review of media multitasking in relation to academic performance.

Google collaborated with Imperial College London and its "Fleming Initiative" partnership with Imperial NHS, giving their scientists "access to a powerful new AI designed" built with Gemini 2.0 "to make research faster and more efficient," according to an announcement from the school. And the results were surprising...

"José Penadés and his colleagues at Imperial College London spent 10 years figuring out how some superbugs gain resistance to antibiotics," writes LiveScience. "But when the team gave Google's 'co-scientist'' — an AI tool designed to collaborate with researchers — this question in a short prompt, the AI's response produced the same answer as their then-unpublished findings in just two days." Astonished, Penadés emailed Google to check if they had access to his research. The company responded that it didn't. The researchers published their findings [about working with Google's AI] Feb. 19 on the preprint server bioRxiv...

"What our findings show is that AI has the potential to synthesise all the available evidence and direct us to the most important questions and experimental designs," co-author Tiago Dias da Costa, a lecturer in bacterial pathogenesis at Imperial College London, said in a statement. "If the system works as well as we hope it could, this could be game-changing; ruling out 'dead ends' and effectively enabling us to progress at an extraordinary pace...."

After two days, the AI returned suggestions, one being what they knew to be the correct answer. "This effectively meant that the algorithm was able to look at the available evidence, analyse the possibilities, ask questions, design experiments and propose the very same hypothesis that we arrived at through years of painstaking scientific research, but in a fraction of the time," Penadés, a professor of microbiology at Imperial College London, said in the statement. The researchers noted that using the AI from the start wouldn't have removed the need to conduct experiments but that it would have helped them come up with the hypothesis much sooner, thus saving them years of work.

Despite these promising findings and others, the use of AI in science remains controversial. A growing body of AI-assisted research, for example, has been shown to be irreproducible or even outright fraudulent.
Google has also published the first test results of its AI 'co-scientist' system, according to Imperial's announcement, which adds that academics from a handful of top-universities "asked a question to help them make progress in their field of biomedical research... Google's AI co-scientist system does not aim to completely automate the scientific process with AI. Instead, it is purpose-built for collaboration to help experts who can converse with the tool in simple natural language, and provide feedback in a variety of ways, including directly supplying their own hypotheses to be tested experimentally by the scientists."

Google describes their system as "intended to uncover new, original knowledge and to formulate demonstrably novel research hypotheses and proposals, building upon prior evidence and tailored to specific research objectives...

"We look forward to responsible exploration of the potential of the AI co-scientist as an assistive tool for scientists," Google adds, saying the project "illustrates how collaborative and human-centred AI systems might be able to augment human ingenuity and accelerate scientific discovery.

"For the first time in history, a privately operated lunar lander has captured images of a total eclipse from the Moon's surface," reports Daily Galaxy.

While the Athena lunar lander tipped over and ended its mission, elsewhere on the moon Firefly Aerospace's Blue Ghost lunar lander "continues to beam home incredible imagery," writes Space.com, and since its landing on March 2 "has been sending us stunning photos and videos..." A new video of Blue Ghost's moon-side view captures the eerie red light on the moon (caused by sunlight refracting through the atmosphere over the edges of the earth). "Blue Ghost turns red!" Firefly writes on their mission updates page.

A SpaceX photographer also captured the eclipse as it happened over a Falcon 9 rocket waiting to launch to the International Space Station, in a remarkable time-lapse photograph.

And Space.com collects more interesting lunar-eclipse photos taken from around the world, including Appin, Scotland; Canberra, Australia; and Palm Springs, California...

"SpaceX founder Elon Musk has said his Starship rocket will head to Mars by the end of next year," writes the BBC, "as the company investigates several recent explosions in flight tests." Human landings could begin as early as 2029 if initial missions go well, though "2031 was more likely", he added in a post on his social media platform X...

The billionaire said in 2020 that he remained confident that his company would land humans on Mars six years later. In 2024, he said he would launch the first Starships to Mars in 2026, with plans to send crewed flights in four years.

Musk has said that the coming Mars mission would carry the Tesla humanoid robot "Optimus", which was shown to the public last year.

"Is everything we see around us is sealed within a black hole?" asks Space.com.

Because here's the thing. The $10 billion James Webb Space telescope (in operation since 2022) "has found that the vast majority of deep space and, thus the early galaxies it has so far observed, are rotating in the same direction. While around two-thirds of galaxies spin clockwise, the other third rotates counter-clockwise." In a random universe, scientists would expect to find 50% of galaxies rotating one way, while the other 50% rotate the other way. This new research suggests there is a preferred direction for galactic rotation... "It is still not clear what causes this to happen, but there are two primary possible explanations," team leader Lior Shamir, associate professor of computer science at the Carl R. Ice College of Engineering, said in a statement. "One explanation is that the universe was born rotating.

"That explanation agrees with theories such as black hole cosmology, which postulates that the entire universe is the interior of a black hole.

"But if the universe was indeed born rotating, it means that the existing theories about the cosmos are incomplete." Black hole cosmology, also known as "Schwarzschild cosmology," suggests that our observable universe might be the interior of a black hole itself within a larger parent universe. The idea was first introduced by theoretical physicist Raj Kumar Pathria and by mathematician I. J. Good. It presents the idea that the "Schwarzchild radius," better known as the "event horizon," (the boundary from within which nothing can escape a black hole, not even light) is also the horizon of the visible universe.
The article cites a theory by Polish theoretical physicist Nikodem Poplawski of the University of New Haven that ultimately black holes don't compress indefinitely into a singularity. "The matter instead reaches a state of finite, extremely large density, stops collapsing, undergoes a bounce like a compressed spring, and starts rapidly expanding," Poplawski explained to Space.com... The scientist continued by adding that rapid recoil after such a big bounce could be what has led to our expanding universe, an event we now refer to as the Big Bang... "I think that the simplest explanation of the rotating universe is the universe was born in a rotating black hole."
Team leader Shamir offers another theory: that we just need to re-calibrate our distance measurements for the deep universe. (Which could also explain the difference in the expansion rates in the universe "and the large galaxies that according to the existing distance measurements are expected to be older than the universe itself.")