According to a new study published in the journal Nature Biotechnology, researchers implanted corneas made from pig collagen to restore sight in 20 people who were blind or visually impaired. "Fourteen of the patients were blind before they received the implant, but two years after the procedure, they had regained some or all of their vision," notes NBC News. "Three had perfect vision after the surgery." From the report: The patients, in Iran and India, all suffered from keratoconus, a condition in which the protective outer layer of the eye progressively thins and bulges outward. "We were surprised with the degree of vision improvement," said Neil Lagali, a professor of experimental ophthalmology at Linkoping University in Sweden who co-authored the study. Not all patients experienced the same degree of improvement, however. The 12 Iranian patients wound up with an average visual acuity of 20/58 with glasses; functional vision is defined as 20/40 or better with lenses. Nonetheless, Dr. Marian Macsai, a clinical professor of ophthalmology at the University of Chicago who wasn't involved in the study, said the technology could be a game changer for those with keratoconus, which affects roughly 50 to 200 out of every 100,000 people. It might also have applications for other forms of corneal disease.

To create the implant, Lagali and his team dissolved pig tissue to form a purified collagen solution. That was used to engineer a hydrogel that mimics the human cornea. Surgeons then made an incision in a patient's cornea for the hydrogel. "We insert our material into this pocket to thicken the cornea and to reshape it so that it can restore the cornea's function," Lagali said. Traditionally, human tissue is required for cornea transplants. But it's in short supply, because people must volunteer to donate it after they die. So, Lagali said, his team was looking for a low-cost, widely available substitute. "Collagen from pigskin is a byproduct from the food industry," he said. "This makes it broadly available and easier to procure." After two years, the patients' bodies hadn't rejected the implants, and they didn't have any inflammation or scarring.

But any experimental medical procedure comes with risk. In this case, Soiberman said, a foreign molecule like collagen could induce an immune reaction. The researchers prescribed patients an eight-week course of immunosuppressive eyedrops to lower the risk, which is less than the amount given to people who receive cornea transplants from human tissue. In those cases, patients take immunosuppressive medicine for more than a year, Lagali said. "There's always a risk for rejection of the human donor tissue because it contains foreign cells," he said. "Our implant does not contain any cells ... so there's a minimal risk of rejection." The procedure itself was also quicker than traditional cornea transplants. The researchers said each operation took about 30 minutes, whereas transplants of human tissue can take a couple of hours. [...] It's not yet clear whether the surgery would work for patients who have other forms of corneal disease aside from keratoconus.

An anonymous reader quotes a report from Phys.Org: In a new University of California, Irvine-led study, researchers define how the circadian clock influences cell growth, metabolism and tumor progression. Their research also reveals how disruption of the circadian clock impacts genome stability and mutations that can further drive critical tumor-promoting pathways in the intestine. In this study, researchers found that both genetic disruption and environmental disruption of the circadian clock contribute to the mutation of the adenomatous polyposis coli (APC) tumor suppressor, which is found in the vast majority of human colorectal cancers (CRC). APC point mutations, deletions, and loss of heterozygosity (LOH) events have been reported in approximately 80 percent of human CRC cases, and it is these mutations that drive the initiation of intestinal adenoma development.

"As a society, we are exposed to several environmental factors that influence our biological clock, including night shift work, extended light exposure, changes in sleep/wake cycles and altered feeding behavior," said Selma Masri, Ph.D., assistant professor of biological chemistry at UCI School of Medicine. "Strikingly, we have seen an alarming increase in several young-onset cancers, including colorectal cancer. The underlying cause of this increased incidence of cancer in adults in their 20s and 30s remains undefined. However, based on our findings, we now believe that disruption of the circadian clock plays an important role." The study has been published in the journal Science Advances.

An anonymous reader quotes a report from The Guardian: China has overtaken the US as the world leader in both scientific research output and "high impact" studies, according to a report published by Japan's science and technology ministry. The report, which was published by Japan's National Institute of Science and Technology Policy (NISTP) on Tuesday, found that China now publishes the highest number of scientific research papers yearly, followed by the US and Germany. The figures were based on yearly averages between 2018 and 2020, and drawn from data compiled by the analytics firm Clarivate.

The Japanese NISTP report also found that Chinese research comprised 27.2% of the world's top 1% most frequently cited papers. The number of citations a research paper receives is a commonly used metric in academia. The more times a study is cited in subsequent papers by other researchers, the greater its "citation impact." The US accounted for 24.9% of the top 1% most highly cited research studies, while UK research was third at 5.5%. China published a yearly average of 407,181 scientific papers, pulling ahead of the US's 293,434 journal articles and accounting for 23.4% of the world's research output, the report found. China accounted for a high proportion of research into materials science, chemistry, engineering and mathematics, while US researchers were more prolific in research into clinical medicine, basic life sciences and physics. "China is one of the top countries in the world in terms of both the quantity and quality of scientific papers," Shinichi Kuroki of the Japan Science and Technology Agency told Nikkei Asia. "In order to become the true global leader, it will need to continue producing internationally recognized research."

Scientists have discovered that by microwaving fish waste, they can quickly and efficiently create carbon nano-onions (CNOs) -- a unique nanoform of carbon that has applications in energy storage and medicine. This method could be used to make cheaper and more sustainable LEDs in the future. The researchers from Nagoya Institute of Technology in Japan published their findings in Green Chemistry. Smithsonian Magazine reports: CNOs are nanostructures with spherical carbon shells in a concentric layered structure similar to an onion. They have "drawn extensive attention worldwide in terms of energy storage and conversion" because of their "exceptionally high electrical and thermal conductivity, as well as large external surface area," per the paper. They've been used in electronics and for biomedical applications, such as bio-imaging and sensing and drug delivery, write the authors in the study. Though CNOs were first reported in the 1980s, conventional methods of manufacturing them have required high temperatures, a vacuum and a lot of time and energy. Other techniques are expensive and call for complex catalysts or dangerous acidic or basic conditions. This "greatly limits the potential of CNOs," per a statement from Nagoya Institute of Technology.

The newly discovered method requires only one step -- microwave pyrolysis of fish scales extracted from fish waste -- and can be done within ten seconds, per the authors. How exactly the fish scales are converted into CNOs is unclear, though the team thinks it has to do with how collagen in the fish scales can absorb enough microwave radiation to quickly increase in temperature. This leads to pyrolysis, or thermal decomposition, which causes the collagen to break down into gasses. These gasses then support the creation of CNOs. This method is a "straightforward way to convert fish waste into infinitely more useful materials," and the resulting CNOs have a high crystallinity, which gives them "exceptional optical properties," per the statement. They also have high functionalization, which means they're "bonded to other small molecules on their surface," writes Ellen Phiddian for Cosmos. This combination of attributes means the CNOs can glow bright blue.

Several weeks after taking over Ukraine's southern port city of Kherson, Russian soldiers arrived at the offices of local internet service providers and ordered them to give up control of their networks. From a report: "They came to them and put guns to their head and just said, 'Do this,'" said Maxim Smelyanets, who owns an internet provider that operates in the area and is based in Kyiv. "They did that step by step for each company." Russian authorities then rerouted mobile and internet data from Kherson through Russian networks, government and industry officials said. They blocked access to Facebook, Instagram and Twitter, as well as to Ukrainian news websites and other sources of independent information. Then they shut off Ukrainian cellular networks, forcing Kherson's residents to use Russian mobile service providers instead.

What happened in Kherson is playing out in other parts of Russian-occupied Ukraine. After more than five months of war, Russia controls large sections of eastern and southern Ukraine. Bombings have leveled cities and villages; civilians have been detained, tortured and killed; and supplies of food and medicine are running low, according to witnesses interviewed by The New York Times and human rights groups. Ukrainians in those regions have access only to Russian state television and radio. To cap off that control, Russia has also begun occupying the cyberspace of parts of those areas. That has cleaved off Ukrainians in Russia-occupied Kherson, Melitopol and Mariupol from the rest of the country, limiting access to news about the war and communication with loved ones. In some territories, the internet and cellular networks have been shut down altogether.

The Biden administration declared monkeypox a public health emergency on Thursday as cases topped 6,600 nationwide. From a report: The declaration could facilitate access to emergency funds, allow health agencies to collect more data about cases and vaccinations, accelerate vaccine distribution and make it easier for doctors to prescribe treatment. "We're prepared to take our response to the next level in addressing this virus and we urge every American to take monkeypox seriously and to take responsibility to help us tackle this virus," Department of Health and Human Services Secretary Xavier Becerra said in a Thursday briefing about the emergency declaration. A quarter of U.S. cases are in New York state, which declared a state of emergency last week. California and Illinois followed suit with emergency declarations Monday.

An anonymous reader quotes a report from Phys.Org: Scientists at the University of Virginia School of Medicine and their collaborators have used DNA to overcome a nearly insurmountable obstacle to engineer materials that would revolutionize electronics. One possible outcome of such engineered materials could be superconductors, which have zero electrical resistance, allowing electrons to flow unimpeded. That means that they don't lose energy and don't create heat, unlike current means of electrical transmission. Development of a superconductor that could be used widely at room temperature -- instead of at extremely high or low temperatures, as is now possible -- could lead to hyper-fast computers, shrink the size of electronic devices, allow high-speed trains to float on magnets and slash energy use, among other benefits.

One such superconductor was first proposed more than 50 years ago by Stanford physicist William A. Little. [...] One possible way to realize Little's idea for a superconductor is to modify lattices of carbon nanotubes, hollow cylinders of carbon so tiny they must be measured in nanometers -- billionths of a meter. But there was a huge challenge: controlling chemical reactions along the nanotubes so that the lattice could be assembled as precisely as needed and function as intended.

[Edward H. Egelman, Ph.D., of UVA's Department of Biochemistry and Molecular Genetics] and his collaborators found an answer in the very building blocks of life. They took DNA, the genetic material that tells living cells how to operate, and used it to guide a chemical reaction that would overcome the great barrier to Little's superconductor. In short, they used chemistry to perform astonishingly precise structural engineering -- construction at the level of individual molecules. The result was a lattice of carbon nanotubes assembled as needed for Little's room-temperature superconductor. [...] The lattice they built has not been tested for superconductivity, for now, but it offers proof of principle and has great potential for the future, the researchers say. The findings have been published in the journal Science.

Live and high-resolution images of a patient's internal organs are already possible with ultrasound imaging technology. But currently the technology "requires bulky and specialized equipment available only in hospitals and doctor's offices," explains an annoncement from MIT.

Now a new design by MIT engineers "might make the technology as wearable and accessible as buying Band-Aids at the pharmacy." In a paper appearing today in Science, the engineers present the design for a new ultrasound sticker — a stamp-sized device that sticks to skin and can provide continuous ultrasound imaging of internal organs for 48 hours.

The researchers applied the stickers to volunteers and showed the devices produced live, high-resolution images of major blood vessels and deeper organs such as the heart, lungs, and stomach. The stickers maintained a strong adhesion and captured changes in underlying organs as volunteers performed various activities, including sitting, standing, jogging, and biking....

From the stickers' images, the team was able to observe the changing diameter of major blood vessels when seated versus standing. The stickers also captured details of deeper organs, such as how the heart changes shape as it exerts during exercise. The researchers were also able to watch the stomach distend, then shrink back as volunteers drank then later passed juice out of their system. And as some volunteers lifted weights, the team could detect bright patterns in underlying muscles, signaling temporary microdamage.

"With imaging, we might be able to capture the moment in a workout before overuse, and stop before muscles become sore," says Chen. "We do not know when that moment might be yet, but now we can provide imaging data that experts can interpret."
They're already envisioning other possibilities: If the devices can be made to operate wirelessly — a goal the team is currently working toward — the ultrasound stickers could be made into wearable imaging products that patients could take home from a doctor's office or even buy at a pharmacy. "We envision a few patches adhered to different locations on the body, and the patches would communicate with your cellphone, where AI algorithms would analyze the images on demand," says the study's senior author, Xuanhe Zhao, professor of mechanical engineering and civil and environmental engineering at MIT.

"We believe we've opened a new era of wearable imaging: With a few patches on your body, you could see your internal organs."

"Two new studies provide more evidence that the coronavirus pandemic originated in a Wuhan, China market where live animals were sold," reports the Associated Press, "further bolstering the theory that the virus emerged in the wild rather than escaping from a Chinese lab."

CNN reports: "All eight COVID-19 cases detected prior to 20 December were from the western side of the market, where mammal species were also sold," the [first] study says. The proximity to five stalls that sold live or recently butchered animals was predictive of human cases... The "extraordinary" pattern that emerged from mapping these cases was very clear, said another co-author, Michael Worobey, department head of Ecology and Evolutionary Biology at the University of Arizona.

The researchers mapped the earliest cases that had no connection to the market, Worobey noted, and those people lived or worked in close proximity to the market. "This is an indication that the virus started spreading in people who worked at the market but then started that spread ... into the surrounding local community as vendors went into local shops, infected people who worked in those shops," Worobey said.

The other study takes a molecular approach and seems to determine when the first coronavirus infections crossed from animals to humans.... The researchers suggest that the first animal-to-human transmission probably happened around November 18, 2019, and it came from lineage B. They found the lineage B type only in people who had a direct connection to the Huanan market.
"All this evidence tells us the same thing: It points right to this particular market in the middle of Wuhan," said Kristian Andersen a professor in the Department of Immunology and Microbiology at Scripps Research and coauthor of one of the studies. The AP quotes Andersen as saying "I was quite convinced of the lab leak myself until we dove into this very carefully and looked at it much closer." Andersen said they found case clusters inside the market, too, "and that clustering is very, very specifically in the parts of the market" where they now know people were selling wildlife, such as raccoon dogs, that are susceptible to infection with the coronavirus.... Matthew Aliota, a researcher in the college of veterinary medicine at the University of Minnesota, said in his mind the pair of studies "kind of puts to rest, hopefully, the lab leak hypothesis."

"Both of these two studies really provide compelling evidence for the natural origin hypothesis," said Aliota, who wasn't involved in either study. Since sampling an animal that was at the market is impossible, "this is maybe as close to a smoking gun as you could get."
CNN notes that Worobey also had initially thought the lab leak had been a possibility, but now says the epidemiological preponderance of cases linked to the market is "not a mirage. It's a real thing.

"It's just not plausible that this virus was introduced any other way than through the wildlife trade." To reduce the chances of future pandemics, the researchers hope they can determine exactly what animal may have first become infected and how.

"The raw ingredients for a zoonotic virus with pandemic potential are still lurking in the wild," said Joel Wertheim, an associate adjunct professor of medicine at the University of California, San Diego. He believes the world needs to do a much better job doing surveillance and monitoring animals and other potential threats to human health.

An anonymous reader quotes a report from Reuters: The oldest patient yet has been cured of HIV after receiving a stem cell transplant for leukaemia, researchers reported on Wednesday. While the transplant was planned to treat the now-66-year-old's leukaemia, the doctors also sought a donor who was naturally resistant to the virus that causes AIDS, a mechanism that first worked to cure the "Berlin patient," Timothy Ray Brown, in 2007.

The latest patient, the fourth to be cured in this way, is known as the "City of Hope" patient after the U.S. facility in Duarte, California, where he was treated, because he does not want to be identified. As well as being the oldest, the patient has also had HIV the longest, having been diagnosed in 1988 with what he described as a "death sentence" that killed many of his friends. He has been on antiretroviral therapy (ART) to control his condition for more than 30 years. [...] Scientists think the process works because the donor individual's stem cells have a specific, rare genetic mutation which means they lack the receptors used by HIV to infect cells. "Scientists think the process works because the donor individual's stem cells have a specific, rare genetic mutation which means they lack the receptors used by HIV to infect cells," adds Reuters.

"After the transplant three and a half years ago, which followed chemotherapy, the City of Hope patient stopped taking ART in March 2021. He has now been in remission from both HIV and leukaemia for more than a year, the team said."

Researchers in Spain also presented a case of a 59-year-old woman who is considered to be in a state of viral remission. "She has now maintained a fully suppressed viral load for over 15 years," reports NBC News. "Unlike the handful of people either cured or possibly cured by stem cell transplants, however, she still harbors virus that is capable of producing viable new copies of itself. Her body has actually controlled the virus more efficiently with the passing years, according to Dr. Juan Ambrosioni, an HIV physician in the Barcelona clinic."

Reuters reports: The rapidly spreading monkeypox outbreak represents a global health emergency, the World Health Organization's highest level of alert, WHO Director-General Tedros Adhanom Ghebreyesus said on Saturday.

The WHO label — a "public health emergency of international concern" — is designed to trigger a coordinated international response and could unlock funding to collaborate on sharing vaccines and treatments. Members of an expert committee that met on Thursday to discuss the potential recommendation were split on the decision, with nine members against and six in favour of the declaration, prompting Tedros himself to break the deadlock, he told reporters. "Although I am declaring a public health emergency of international concern, for the moment this is an outbreak that is concentrated among men who have sex with men, especially those with multiple sexual partners," Tedros told a media briefing in Geneva.

A 37-year-old junior professor in Tennessee "identified apparently altered or duplicated images in dozens of journal articles," reports Science magazine.

But that was just the beginning for Matthew Schrag, whose sleuthing then "drew him into a different episode of possible misconduct, leading to findings that threaten one of the most cited Alzheimer's studies of this century and numerous related experiments." The first author of that influential study, published in Nature in 2006, was an ascending neuroscientist: Sylvain Lesné of the University of Minnesota, Twin Cities. His work underpins a key element of the dominant yet controversial amyloid hypothesis of Alzheimer's, which holds that A clumps, known as plaques, in brain tissue are a primary cause of the devastating illness, which afflicts tens of millions globally. In what looked like a smoking gun for the theory and a lead to possible therapies, Lesné and his colleagues discovered an A subtype and seemed to prove it caused dementia in rats.

If Schrag's doubts are correct, Lesné's findings were an elaborate mirage....

A 6-month investigation by Science provided strong support for Schrag's suspicions and raised questions about Lesné's research. A leading independent image analyst and several top Alzheimer's researchers — including George Perry of the University of Texas, San Antonio, and John Forsayeth of the University of California, San Francisco (UCSF) — reviewed most of Schrag's findings at Science's request. They concurred with his overall conclusions, which cast doubt on hundreds of images, including more than 70 in Lesné's papers. Some look like "shockingly blatant" examples of image tampering, says Donna Wilcock, an Alzheimer's expert at the University of Kentucky. The authors "appeared to have composed figures by piecing together parts of photos from different experiments," says Elisabeth Bik, a molecular biologist and well-known forensic image consultant. "The obtained experimental results might not have been the desired results, and that data might have been changed to ... better fit a hypothesis...."

Schrag's work, done independently of Vanderbilt and its medical center, implies millions of federal dollars may have been misspent on the research — and much more on related efforts. Some Alzheimer's experts now suspect Lesné's studies have misdirected Alzheimer's research for 16 years. "The immediate, obvious damage is wasted NIH funding and wasted thinking in the field because people are using these results as a starting point for their own experiments," says Stanford University neuroscientist Thomas Südhof, a Nobel laureate and expert on Alzheimer's and related conditions.

Lesné did not respond to requests for comment....

Some Alzheimer's experts see a failure of skepticism, including by journals that published the work.
Schrag has warned America's National Institutes of Health that the suspect work "not only represents a substantial investment in [NIH] research support, but has been cited ... thousands of times and thus has the potential to mislead an entire field of research."

And Harvard neurologic disease professor Dennis Selkoe told Science "There are certainly at least 12 or 15 images where I would agree that there is no other explanation" than manipulation. Selkoe's bigger worry, he says, is that the Lesné episode might further undercut public trust in science during a time of increasing skepticism and attacks. But scientists must show they can find and correct rare cases of apparent misconduct, he says. "We need to declare these examples and warn the world."
Thanks to Slashdot reader Crypto Fireside for sharing the story!

An unvaccinated young adult from New York recently contracted polio, the first U.S. case in nearly a decade, health officials said Thursday. The Associated Press reports: Officials said the patient, who lives in Rockland County, had developed paralysis. The person developed symptoms a month ago and did not recently travel outside the country, county health officials said. It appears the patient had a vaccine-derived strain of the virus, perhaps from someone who got live vaccine -- available in other countries, but not the U.S. -- and spread it, officials said. The person is no longer deemed contagious, but investigators are trying to figure out how the infection occurred and whether other people may have been exposed to the virus. The report notes that polio was declared eliminated in the U.S. in 1979, "meaning there was no longer routine spread."

Amazon is acquiring One Medical for $18 a share, an all-cash deal that values the primary health care provider at roughly $3.9 billion, the companies said Thursday. From a report: The deal deepens Amazon's presence in health care, which Neil Lindsay, senior vice president of Amazon Health Services, said is "high on the list of experiences that need reinvention."

The e-commerce giant hopes to improve how people book appointments and the experience of being seen by a physician, Lindsay said in a statement. "We love inventing to make what should be easy easier and we want to be one of the companies that helps dramatically improve the healthcare experience over the next several years," he said.

Apple published a nearly 60-page report Wednesday outlining all its health features and partnerships with medical institutions, arguing that such offerings are key to the tech giant's future. From a report: The company pointed to its breadth of existing services -- from sleep monitoring and fitness classes to atrial-fibrillation detection and cycle tracking -- and promised to build on that foundation. Chief Operating Officer Jeff Williams, who oversees Apple's health endeavors, said in a statement attached to the report that the company will continue to innovate in "science-based technology."

"The health innovations we've pioneered have aimed to help break down barriers between users and their own everyday health data, between health-care providers and patients, and between researchers and study participants," he said. The report serves as a response to Apple critics, who have knocked the company for not doing as much as rivals in health care. Though the Apple Watch dominates the market, the device hasn't always gotten novel health features as quickly as competitors' products. And fellow tech titans such as Amazon.com and Google have made ambitious forays into the medical field -- with mixed results. Apple is arguing that it's a pioneer in health technology and positioned to use it as a growth driver in the years ahead.

An anonymous reader quotes a report from Business Insider: Synchron, a brain-computer interface startup, reportedly implanted its first device in a US patient earlier this month. The startup implanted a 1.5-inch device into the brain of an ALS patient at Mount Sinai West medical center in New York on July 6, Bloomberg first reported. The purpose of the device is to allow the patient to communicate -- even after they have lost the ability to move -- by using their thoughts to send emails and texts. Bloomberg reported that Synchron has already implanted the device in four patients in Australia who have been able to use the brain implant to send messages on WhatsApp and shop online. Elon Musk's Neuralink has a similar mission, but is still waiting for FDA approval. "Neuralink and Synchron's products have several key differences: namely, size and installation," notes the report. "The Australian startup's product can be inserted into a human skull without cutting into it using a catheter that feeds the device through the jugular vein into a blood vessel in the brain. The process requires two separate surgeries."

"In contrast, Neuralink plans to make a much smaller and more powerful device that would require a portion of the individual's skull to be removed and would be performed using a robot." Neuralink also appears to be slightly more ambitious, with Musk referring to the device as "a Fitbit in your skull."

Two cases of the deadly Marburg virus have been identified in Ghana, the first time the Ebola-like disease has been found in the west African nation. From a report: Earlier in the month, blood samples taken from two people in the southern Ashanti region suggested they had the Marburg virus. The samples were sent to the Pasteur Institute in Senegal, which confirmed the diagnosis, the Ghana Health Service (GHS) said. "This is the first time Ghana has confirmed Marburg virus disease," said the GHS head, Patrick Kuma-Aboagye. No treatment or vaccine exists for Marburg, which is almost as deadly as Ebola. Its symptoms include high fever as well as internal and external bleeding. Ninety-eight people identified as contact cases were under quarantine, the GHS statement said, noting that no other cases of Marburg had yet been detected in Ghana. The World Health Organization declared Ghana's first outbreak. "Health authorities have responded swiftly, getting a headstart preparing for a possible outbreak," said the WHO regional director for Africa, Dr Matshidiso Moeti.

A new paper, published in the journal Science, found that when the Y chromosome was gone from blood cells in male mice genetically engineered to lose their Y chromosomes, scar tissue built up in the heart, leading to heart failure and a shortened life span. The New York Times reports: Because there was a direct cause-and-effect relationship between the loss of Y and ailments of aging in the mice, the study bolsters the notion that the same thing can happen in human males. Researchers have documented an increase in risk for chronic diseases like heart disease and cancer related to loss of the Y chromosome in many studies over the years, including the new one, which used data from a large genetic study of the British population. The loss of Y could even account for some of the difference between the life spans of men and women, the authors of the Science study say.

At least 40 percent of males lose the Y chromosome from some of their blood cells by age 70. And by age 93, at least 57 percent have lost some of it. The chromosome is lost sporadically from blood cells during cell division, when it is kicked out of some cells and then disintegrates. The result is what researchers call a mosaic loss of Y. There is no way, other than to stop smoking, to reduce the risk of losing the Y chromosome. And the condition is unrelated to men having lower levels of testosterone in their bodies as they age. Taking testosterone supplements would have no effect, nor would it reverse the consequences. [...]

It is too soon to say what men should do -- other than to stop smoking -- to protect themselves from losing their Y chromosomes or to alleviate the consequences. Those in [the researcher's] group found they could protect the hearts of the mice without Y chromosomes by blocking TGF-beta, a key molecule involved in the production of scar tissue. Dr. Stephen Chanock, the director of the division of cancer epidemiology and genetics at the National Cancer Institute, said the mouse study was "really cool." But he noted that there was no evidence yet that drugs to block TGF-beta would be effective in men who lost their Y. And, for now, there is little point in testing men for loss of Y, Dr. Chanock said, adding, "the over-interpretation of these data for monetary purposes worries me deeply."

Some Beijing residents returning from domestic travel were asked by local authorities to wear COVID-19 monitoring bracelets, prompting widespread criticism on Chinese social media by users concerned about excessive government surveillance. Reuters reports: According to posts published on Wednesday evening and Thursday morning on microblogging platform Weibo, some Beijing residents returning to the capital were asked by their neighborhood committees to wear an electronic bracelet throughout the mandatory home quarantine period. Chinese cities require those arriving from parts of China where COVID cases were found to quarantine. Authorities fit doors with movement sensors to monitor their movements but until now have not widely discussed the use of electronic bracelets.

The bracelets monitor users' temperature and upload the data onto a phone app they had to download, the posts said. "This bracelet can connect to the Internet, it can definitely record my whereabouts, it is basically the same as electronic fetters and handcuffs, I won't wear this," Weibo user Dahongmao wrote on Wednesday evening, declining to comment further when contacted by Reuters. This post and others that shared pictures of the bracelets were removed by Thursday afternoon, as well as a related hashtag that had garnered over 30 million views, generating an animated discussion on the platform.

A community worker at Tiantongyuan, Beijing's northern suburb, confirmed to state-backed news outlet Eastday that the measure was in effect in the neighbourhood, though she called the practice "excessive." A Weibo post and a video published on the official account of Eastday.com was removed by Thursday afternoon. Weibo user Dahongmao wrote on Thursday afternoon his neighbourhood committee had already collected the bracelets, telling him that "there were too many complaints."

An anonymous reader quotes a report from The Verge: Researchers successfully transplanted genetically modified pig hearts into two recently deceased people connected to ventilators, the New York University team announced today. The surgeries are the latest step forward in the field of animal-to-human transplants, or xenotransplantation, which has seen a flurry of successes so far this year -- raising hopes for a new, steady supply of organs to ease shortages. The only thing different about these heart transplants from a normal human-to-human heart transplant was the organ itself, the research team said in a statement.

The team performed the transplants on June 16th and July 9th, and each recipient was monitored for three days. In that time, the hearts functioned normally, and there weren't signs of rejection from the recipients, who were connected to ventilators to keep their body processes functioning semi-regularly, even after death. The two recipients were not able to be organ donors but were able to participate in whole-body donation for this type of research. The two pig hearts came from biotechnology company Revivicor, which produces genetically modified pigs (and also funded the research). The pigs had 10 genetic modifications -- four to block pig genes and prevent rejection and six to add human genes. A living person was successfully given a pig heart in early January, notes the report. While the person responded well to the transplant initially, they died of heart failure in March.

"The specific cause is still unknown, but infection with a pig virus may have contributed to his death," adds The Verge. "The pig hearts are supposed to be free of viruses, but experts say they can be hard to detect." A research paper in late June details everything that went wrong with the transplant.