Ageing Accelerates at Around Age 50 - Some Organs Faster Than Others (nature.com) 40
A new analysis of protein changes across human tissues has identified an aging acceleration point around age 50, with blood vessels showing the most dramatic deterioration. Researchers examined tissue samples from eight body systems in 76 people of Chinese ancestry aged 14 to 68 who died from accidental brain injury, finding age-related increases in 48 disease-associated proteins.
Between ages 45 and 55, the most significant shift occurred in the aorta, the body's main artery carrying oxygenated blood from the heart. The team identified one aortic protein that triggers accelerated aging signs when administered to mice. Early aging changes appeared around age 30 in the adrenal gland, which produces various hormones. The study, published in Cell, adds to mounting evidence that aging occurs in waves rather than following a steady progression.
Between ages 45 and 55, the most significant shift occurred in the aorta, the body's main artery carrying oxygenated blood from the heart. The team identified one aortic protein that triggers accelerated aging signs when administered to mice. Early aging changes appeared around age 30 in the adrenal gland, which produces various hormones. The study, published in Cell, adds to mounting evidence that aging occurs in waves rather than following a steady progression.
NRA: Idaho (Score:4, Insightful)
"How did you go bankrupt?" Bill asked.
"Two ways," Mike said. "Gradually and then suddenly."
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Lots of friends going well till early 60's and then BAM, everyone getting hit with health problems.
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Nah, turns out the extended warranty is just a scam.
Gradually... (Score:2)
"How did you go bankrupt?" Bill asked.
"Two ways," Mike said. "Gradually and then suddenly."
Don't forget to credit Ernest Hemingway for the quote (from The Sun Also Rises).
Re: Gradually... (Score:2)
What if the Fed, suddenly, bails you out, because you're too big to fail?
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Well, that's sad... (Score:5, Funny)
Whatever comes out of this research will be too late to save most of us slashdotters.
But then, Netcraft did confirm our death decades ago.
As soon as they say "mice" (Score:2)
Why do I prefer death to using knowledge gained from torturing fellow mortals?
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The issue is morally complex.
We need the scientific knowledge to save human lives, in potentially very large numbers. If we sit on our hands and just let them die, then we commit a moral sin of inaction.
But the only way to obtain the knowledge involves experimentation that brings suffering and death to a small number of animals. Imposing needless suffering and death on living beings is also a moral sin.
Dammed if you do, dammed if you don't.
The discriminating principle then becomes one of value. Human liv
Re: As soon as they say "mice" (Score:1)
"we commit a moral sin of inaction"
What if everything we do medically is just placebo anyway so we can avoid all the animal torture? Is it possible you will keep coming up with excuses why we need to be violent, because you simply like violence?
Life enjoyment (Score:2, Insightful)
It's OK (Score:3)
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I self-identify as a perpetual 30 year old so I should be fine.
Me too! I'm trans-age and age-fluid.
Gee thanks (Score:2)
Aging occurs in stages (Score:3)
And yeah, for me, 48 years old was the big downslide. So many small things start going wrong at the same time. And the maddening thing is, you still feel young inside. It's just that you slowly give up on stuff because the body doesn't follow. It's like seeing opportunities disappear and doors closing. Not fun...
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I'm 48 and holy crap I must agree. My back is hurting on and off, never used to. Foods I used to eat just fine now make me feel bleah and sick to my stomach. I've needed new eyeglass prescriptions four times in the last five years; before I went with the same prescription for a decade.
It's perfectly normal but still scary. It's like suddenly your body goes "Okay I've had enough" and yells at you to take it easier.
I hate it.
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Thankfully, lifestyle can have a big impact on the age when this slide starts to occur. At 59, by eating (mostly) healthy and daily bike rides, I've been able to stay healthier than most 50-year-olds. Sure, I feel an occasional twinge of early arthritis, and I've had cataract surgery. But I'm *far* more healthy than my own younger brother. Some of that is genetics, but a lot comes down to how well you take care of yourself.
Well thats encouraging... (Score:3)
...for someone wearing C/pap with 80 breath stops an hour. Fun times ahead for me.
Well - accelerated fun living it is then, live it up folks!
Transalation (Score:1)
Next story: How to build your digital gravestone with Free software.
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Makes sense that organs age varying-ly (Score:2)
The jokes are real! (Score:2)
I think we've all experienced this. At 30-ish, suddenly you can't drink as much, your neck and back start to get tweaked more often, you're not as powerful an athlete as you used to be (though sometimes you get better in other ways).
At 40 my eyesight started to go. I started wearing computer glasses. My aches and pains were worse, and I took so much longer to heal. I went on statins because even while I stayed athletic and ate pretty well, I just couldn't get my triglicerides any lower.
I'm 48 now, and I'll
Exercise (Score:2)
When you are in your teens and twenties you are in your physical prime and everything comes easy to you with little exercise. Later in life its more like the Red Queen, "it takes all the running you can do, to keep in the same place. If you want to get somewhere else, you must run at least twice as fast as that!".
You are going to need to do some serious exercise as you get older in order to keep the health you used to get for free. And I don't mean taking leisurely walks either, it has to seriously work you
What's the distribution? (Score:2)
News articles like to talk about a single inflection point because it's easier for everyone to understand. However, the likely reality is that there is a distribution. The shape and width of that distribution is just as important, if not more important. Do some people see this effect at age 40 or age 70? Are there genetic or environmental effects? Or is this a threshold that is independent of genetics and environment?
Unfortunately the article is paywalled.
I was OK at 53, but at 56 it's catching up (Score:1)
At 53, I lost some weight, and felt and looked healthier than I had been in many years. Doctors were happy with my condition. As had been the case for all my life, in my photos, I looked far younger than I was.
Just three years later, I now look my age, for the first time ever. My appearance aged many years in a short time. I now have to do "intermittent fasting", about 40 hours of no food, two or three times per week. Not because it's a fad, not because I'm trying to get thin, but just to fix my digesti
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Can confirm (Score:2)
I lost an organ the year I turned 50. Had to get a transplant.
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I was one of those who always looked much younger than my actual age. Then, when I was 53, my left internal carotid artery unraveled. Right out of the blue. Besides the obvious plumbing issue, there was collateral damage to the wiring, and there are neurological issues as well. I have no stamina (chronic fatigue), my eyes are all fracked up, and I have serious vertigo problems - like just falling down at random times. I call it 'tumbling the gyros'. Lord knows how many micro-strokes I had before it smoothly