One Shot To Stop HIV: MIT's Bold Vaccine Breakthrough (sciencedaily.com) 72
ScienceDaily reports:
Researchers from MIT and Scripps have unveiled a promising new HIV vaccine approach that generates a powerful immune response with just one dose. By combining two immune-boosting adjuvants alum and SMNP the vaccine lingers in lymph nodes for nearly a month, encouraging the body to produce a vast array of antibodies. This one-shot strategy could revolutionize how we fight not just HIV, but many infectious diseases. It mimics the natural infection process and opens the door to broadly neutralizing antibody responses, a holy grail in vaccine design. And best of all, it's built on components already known to medicine.
Thanks to Slashdot reader alternative_right for sharing the news.
Thanks to Slashdot reader alternative_right for sharing the news.
Oh well (Score:2)
20 years too late for my mate "littlewolf" ..
Re:Oh well (Score:4, Interesting)
20 years too early for right wing fundamentalists.
They really want this to be gods wrath for people doing stuff they don't want to admit they do out of sight
Anybody else wondering why trump-tards are shutting down research in this country?
Re: Oh well (Score:2)
You sound like you work for big pharma. Don't cure, just keep them on a drug cocktail forever.
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You sound like you work for big pharma. Don't cure, just keep them on a drug cocktail forever.
You sound like a conspiracy theorist.
Vaccines don't cure anything. At best they may help "train" the immune system to fight off a disease which can maybe aid in recovery but most often it is pointless to give a vaccine after the infection.
Since this is not a cure the best practice is to be sanitary so as to not get infected in the first place. Because we know hot HIV spreads, and the acts that produce the highest risk are pretty easy to avoid as it's not like people are getting HIV because they touched a
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If people with HIV can't keep their pants on, use a condom, or just keep it among themselves, then they need to be locked up.
It's not 1985 grandpa there no need for such dramatics, HIV rates have been declining for a long time (2022 there were 32k new cases, down 12% from 2018). Turns out a bunch of awareness and education works.
Also talk about making a law that would only encourage people to keep their diagnosis a secret or purposefully never confirm if they had it to begin with.
https://www.hiv.gov/hiv-basics... [hiv.gov]
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It's not 1985 grandpa there no need for such dramatics, HIV rates have been declining for a long time (2022 there were 32k new cases, down 12% from 2018). Turns out a bunch of awareness and education works.
Education works? Such as telling people not to sleep around? Use a condom if they do? Or keep their time in bed with a single partner? Wow, that's like, "grandpa" stuff that we should not be telling kids in high school. Did you think that through?
Also talk about making a law that would only encourage people to keep their diagnosis a secret or purposefully never confirm if they had it to begin with.
When people start showing up sick because of some rare disease then HIV will be suspected and tested for. At some point people will find out and trace things back to a "Typhoid Mary" and start asking questions. Then people in this chain will be informed of t
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I'm seeing Trump pull back on government funded research as a means to trim the federal budget.
C'mon, we all know this is BS, why are you repeating it? Trump (and his administration) don't care about "trimming the federal budget". They are ideologically opposed to many things the federal government does and are cutting those programs. Claiming that doing so saves the federal government money is clearly a smokescreen for their actual goals.
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Just one point: "free love" actually has a historical definition. It means that sexual activity should not be regulated by governments. That would also, technically, include the right to practice celibacy.
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"Free love" during the "sexual revolution" was about rejecting traditional, non-governmental, morals and prohibitions on sexual activity. It wasn't just "sex the government doesn't explicitly sanction in the institution of contract marriage", it was "sex without regard to consequences".
Sexual activity has inherent consequences, including physical, emotional, and spiritual consequences. Pretending that you can have sex "free" from consequences is one of the great lies of the 1900s.
How long until RFK Jr. tries to outlaw it? (Score:5, Funny)
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Amen!
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Re:Lemme get on my soapbox for a second (Score:5, Informative)
Thanks for demonstrating that you are fucking idiot
mRNA vaccines are terrifically effective, do not rely on eggs for incubation (that is why avian flu is a threat) and will spawn the next generation of cancer treatments that will eliminate it as a common form of death
You are welcome to go somewhere else and spread your anti-vax lies, just make sure you are prepared to watch your loved ones die while everybody else enjoys their benefits
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That was really convincing. For a long moment I thought you were serious! 8-)
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big pharma and governmental oversight needs to be looked at.
I'll remind you that this was 100% overseen by the Trump administration. OOps. Start backpedaling in 3..2..1.. "But but but dear orange leader had no choice because some Democrat!!!"
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"But but but dear orange leader had no choice because some Democrat!!!"
Some democrat? It is obviously Biden's fault.
Re: Lemme get on my soapbox for a second (Score:3)
FWIW, shutdowns and mandates were done by the state. States rights are a thing and you, as a USA citizen, are welcome to relocate to a different state which did not implement draconian measures. The government worked the way it should have during this time.
Re: Lemme get on my soapbox for a second (Score:2)
Re: Lemme get on my soapbox for a second (Score:2)
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Uh oh. You triggered the big pharma dudes with mod points.
One day, our institutions will earn back their credibility. Today, is obviously not that day.
Re:How long until RFK Jr. tries to outlaw it? (Score:5, Informative)
RFK, Jr, recently replaced all 17 members of the Advisory Committee on Immunization Practice (ACIP) at the CDC with (so far) 8 new members, including Dr. Robert Malone who has said that the COVID-19 vaccine could cause AIDS.
From: Vaccine Skeptics Among CDC Vaccine Panel Replacements Named by RFK Jr [ajmc.com] and Google: malone vaccine cause aids [google.com]
Malone has also previously said that the COVID-19 vaccine could cause a form of AIDS and that Americans were hypnotized into getting vaccinated.
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Who are going to moan about why we need an HIV vaccine think about this. What makes you think it will only work on HIV? We could turn it loose on any number of viruses.
I would not expect this to work with anything other than HIV because a vaccine for one strain of COVID-19 will fail to protect against a very closely related different strain. The same goes for the seasonal flu shots, if the people making the shots guess wrong on which flu strains are "popular" that season then they will fail to protect the population from the flu.
I used to get a really bad flu nearly every year up until I got to be 20 years old or so. Since then I'd still get a flu here and there but it
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>>I got my two COVID-19 shots but I still ended up testing positive for COVID-19 twice. That sucked as it was more like four days of being a lump on the couch than just one. If I was told which variant of the virus I had then I don't recall.
And yet, you are not dead... so the vaccines you took were effective. As far as your other claims... nobody is trying to claim that the HIV vaccine will be used on other diseases, BUT that the techniques used to create the vaccine will be
On one hand, the fact that
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And yet, you are not dead... so the vaccines you took were effective.
The claim was that the vaccine would prevent infection, when that proved wrong the goalposts were moved to claim it was to reduce the symptoms.
Since so few people died from COVID-19 in the first place it is difficult to know if any of the vaccines did anything helpful. Well, that's "few" as in less than 1% of the population of those infected with that first wave of the deadliest strains, and most of those that died were over 75 years of age. My risk of death was quite small to begin with so it's hardly pr
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The goal was always that the vaccine would reduce the rate of death in the general population from a novel virus that they did not have any related immunity for
NOBODY was selling a 100% reduction in infection, and you claiming that is just "moving the goalposts" , if I could be so bold as to quote your hypocritical self
Go back to 4chan pol and get praises from your buddies, nobody here is buying what you are shilling
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Any disease can do that too.
Biology is just a shitty way to run a conscious mind.
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Why is this post downmodded? Seems more on topic and appropriate than all the stupid Trump posting.
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Because it was loony. Dude espoused an amazingly false understanding of the purpose and functionality of adjuvants.
The way our immune system works is that co-factors are usually needed to alert it to the presence of new dangers. Because usually, in nature, whenever a foreign agent is inserted into the blood, it's never a single agent. For example, if a bacteria enters the blood .. it has various lipids and other metabolites simultaneously. That causes multiple parts of the immune systems to activate in a sy
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typo: Lonestar Tick
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Saying "we got a vaccine that works by loading it full of adjuvants" is another way of saying, god help the poor schmucks who participate in the future safety trial. It is never coming to market.
Immunological adjuvants are in use for a century, initially named in 1923 by veterinarian Gaston Ramon https://en.wikipedia.org/wiki/... [wikipedia.org] following his studied on horses used to produce diphtheria antitoxin (= antibodies). His methods to manufacture diphtheria and tetanus vaccines are still used today.
Did anyone else read "SNMP"? (Score:2)
I had to read more closely to see that didn't say what I thought it said. From the Scripps article: A second strategy employed saponin/MPLA nanoparticles (SMNP).
Re: Did anyone else read "SNMP"? (Score:2)
Here too
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It actually was a bit of a search to find "SMNP", so my original post was both a commentary on how our eyes tend to see what we expect, and to provide the acronym expansion for the lazy among us...
The timing couldn't be worse (Score:5, Interesting)
By the beginning of Trump's third term you will have to travel to Europe or Mexico or Canada to get a vaccination.
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I could get total admin support with one sentence:
"Mr. Trump how would you like to go out in front of crowds and say 'I cured AIDS'"? He'll probably ask for the biology Nobel!
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trump is supported by the Heritage Foundation, a fundamentalists, right -wing group that believe HIV is gods punishment for doing naughty things
What trump will do, is make these treatments available only for the rich, while leaving the masses to spends millions of half-cures or die when their medicare is cut
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See I don't believe Trump actually cares about heritage beyond their loyalty and political support. If he actually wanted to shift gears they would follow him, the entire conservative establishment is servile.
Also this is HIV which isn't that something that is as politically dividable as covid or childhood vaccinations so there wouldn't be as much opposition. A normal human being might call that hypocritical but these people have no sense of that or shame anymore. The narrative is all that matters.
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A little history would help
Reagan refused to address AIDs epidemic because... God's Punishment
The Heritage Foundation were around back then, and supported Reagan
Trump relies on Heritage Foundation support to keep power, and power is the only thing that matters to him
As a result, expect to get Heritage foundation lies shoved down your throat as long as trump is in power
That isn't curing AIDS (Score:2)
To the kind of person in the 46 to 47% who currently support Donald Trump in spite of everything you can't cure something that you aren't suffering from. Everything has to be dramatic to those people. So you have to have somebody who very very very very obviously has AIDS and is dying from it and then gets better like magic. That's curing.
Those people
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He doesn't care. It wouldn't be going to his supporters for the most part, and some of the more vocal ones will criticize him for it.
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So you are all right with the payoffs from Pharma?
"Seven other panel members received between $4,000 and $55,000 from drugmakers for consulting, speaking fees, travel or meals over the period 2017 to 2023. Two of those experts had also worked with other scientists in industry-funded research projects worth several millions of dollars."
https://www.reuters.com/busine... [reuters.com]
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Sure, but first there's nothing in there that shows an evidence of wrongdoing and second are Kennedy and Trump changing rules and laws that would prevent this from happening? Has his picks taken plednges to not take any consulting gigs or do any research or anything at all with biotech firms?
Something smells like selective outage and just replacing one conflict of interest with a different one.
https://www.npr.org/sections/s... [npr.org]
In fact, Meissner, a professor of pediatrics and medicine at Dartmouth College's G
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Besides that, we all know all the vitamin and supplement industries are beyond reproach.
Too bad Trump Cancelled the lab funding (Score:5, Informative)
President Donald Trump cut the lab funding.
https://spectrumnews1.com/ca/s... [spectrumnews1.com]
You can't make a vaccine without trials and without labs.
Welp, enjoy your science harvest while you can (Score:2)
Cause this shit ain't going to last. With Trumpkins cutting off the science funding, we're just gonna get another year or two of breakthroughs before the well dries up. Hopefully all the scientists going to other countries will do good work. My PhD cousin is looking for his postdoc 100% outside of America.
Just add soap! (Score:2)
"This molecule naturally joins together with saponin molecules to form saponin/MPLA nanoparticles (SMNP).
At LJI, Scientific Associate Yu Kato, Ph.D., started by spearheading experiments to understand exactly what makes saponin adjuvants effective.
Experiments in mice showed that a saponin adjuvant triggers a strong response from the body’s germinal centers, structures in the lymph nodes that pump out B cells. A saponin adjuvant also led to better T cell and class-switched antibody responses (which allo
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It's called "soap tree" because a solution of the extract makes foam, like soap. This is not, however a saponified fat or an alkali that will saponify fat. It is a molecule with a hydrophilic part tied to a lipophilic part.
Another example from pharmacy is the common blood pressure drug olmesartan/medoxomil, where lipophilic olmesartan is tied to hydrophilic medoxomil, with an interesting bridge. The bridge is diacetyl, aka butter popcorn artificial flavor. Sniff a bottle of Benicar (or generic) tablets
One Shot (Score:4, Funny)
Great! Hand all the right-wingers hypodermic dart rifles loaded with this stuff. Tell them to go hunt LGBTQ+ people and addicts. Everyone is happy.
Probably won't get approved for use in the US (Score:2)
Considering the current anti-science, anti-vaccination regime in the US, it will be difficult to get this vaccine approved.
Politics (Score:2)
And to think, I came to the comments to actually see if there were some insightful posts addressing some questions I have about this new technology/method, and if not, post questions. And what I find is pretty much all the same political crap every time vaccines come up.
So I guess there is no point asking :(
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Your low UID is showing, Reddit is where sincere, moderated discussions are going on. /. is a culture war shitshow these days, not that I am opposed to it considering the 'opposition' is pure Idiocracy
IMO, it has never recovered from the Dice days and attempts to monetize it, but I still show up to tell shills to get offa my lawn