One Shot To Stop HIV: MIT's Bold Vaccine Breakthrough (sciencedaily.com) 104
ScienceDaily reports:
Researchers from MIT and Scripps have unveiled a promising new HIV vaccine approach that generates a powerful immune response with just one dose. By combining two immune-boosting adjuvants alum and SMNP the vaccine lingers in lymph nodes for nearly a month, encouraging the body to produce a vast array of antibodies. This one-shot strategy could revolutionize how we fight not just HIV, but many infectious diseases. It mimics the natural infection process and opens the door to broadly neutralizing antibody responses, a holy grail in vaccine design. And best of all, it's built on components already known to medicine.
Thanks to Slashdot reader alternative_right for sharing the news.
Thanks to Slashdot reader alternative_right for sharing the news.
Oh well (Score:3)
20 years too late for my mate "littlewolf" ..
Re:Oh well (Score:4, Interesting)
20 years too early for right wing fundamentalists.
They really want this to be gods wrath for people doing stuff they don't want to admit they do out of sight
Anybody else wondering why trump-tards are shutting down research in this country?
Re: Oh well (Score:1)
You sound like you work for big pharma. Don't cure, just keep them on a drug cocktail forever.
Re: (Score:3)
Big pharma companies would love to invent more cures: who wouldn't want to own the entire market for a disease instead of having to compete with other treatments? But cures are typically much more difficult to develop, and in many cases will have to be tailored to individual patients. We're really only beginning to have the level of sophistication nece
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If people with HIV can't keep their pants on, use a condom, or just keep it among themselves, then they need to be locked up.
It's not 1985 grandpa there no need for such dramatics, HIV rates have been declining for a long time (2022 there were 32k new cases, down 12% from 2018). Turns out a bunch of awareness and education works.
Also talk about making a law that would only encourage people to keep their diagnosis a secret or purposefully never confirm if they had it to begin with.
https://www.hiv.gov/hiv-basics... [hiv.gov]
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It's not 1985 grandpa there no need for such dramatics, HIV rates have been declining for a long time (2022 there were 32k new cases, down 12% from 2018). Turns out a bunch of awareness and education works.
Education works? Such as telling people not to sleep around? Use a condom if they do? Or keep their time in bed with a single partner? Wow, that's like, "grandpa" stuff that we should not be telling kids in high school. Did you think that through?
Also talk about making a law that would only encourage people to keep their diagnosis a secret or purposefully never confirm if they had it to begin with.
When people start showing up sick because of some rare disease then HIV will be suspected and tested for. At some point people will find out and trace things back to a "Typhoid Mary" and start asking questions. Then people in this chain will be informed of t
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In many places, it is indeed criminal to intentionally expose people to HIV. Problem is, few get tested. Outbreaks, especially with shared needles as an infection vector, happen somewhat frequently.
It's not ignorance, it's sloth and poverty, shame in finding public health clinics or telling a PCP.
There are people that also have (a lot) of casual sex. Or their partner secretly does, infecting them.
Education about partner protection does indeed help right now, but now all will learn the lesson, get motivated,
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Sex drive is huge. So is drug dependency; you'll get rid of neither.
I agree, but there's no excuse for unprotected sex for anyone with powerful sex drive. Condoms are everywhere, many times given out for free. I remember having to go to some university medical office to clear up some paperwork on my immunizations, as soon as I entered the door there was a huge bowl of condoms for students to take. It was bitterly cold outside and the office was a bit of a walk to the next building, this prompted someone behind the desk to ask if I was there for a visit or just needed to
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No excuse?
You have to face reality. Your sense of propriety is not the sense of others, for better and worse.
You can yell at the sky for those rain drops to go back to the clouds of their origin, but it's not going to happen.
Face that. It is real. That's why this breakthrough is so important. The closer we get to statistical protection, the more the curve flattens. The fact that the curve flattens flies in the face of your sense of morality or of mine. It really flattens it. That's the entire point.
Neither
Re: Oh well (Score:3)
Being poz wasn't a death sentence a decade ago, provided you had access to HAART. Even for 2 decades, which is almost how long I have been poz.
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You're a lucky man in a privileged country.
Re: Oh well (Score:4, Interesting)
Yes, but it's hardly just me.
PEPFAR has saved over 20 millions lives worldwide by providing very low cost ARVs to needy populations in very poor countries, notably in Africa and Asia.
I'm no big fan of GWB, but this program of his has been very successful.
Unfortunately, Trump has cancelled USAID funding for PEPFAR, and lives of these tens of millions are now at risk.
Even if another country picks up the slack, any interruption of ARV is risky for patients. The cancellation of PEPFAR may kill more people than the Holocaust.
Americans with HIV/AIDS are also at risk with funding cuts to Medicaid, NIH, PreP, sex education, and so on. And if people are not on HAART or on PreP, new infections will rebound.
Trump is MakIng AIDS Great Again.
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We totally agree these are worthwhile programs.
As this relates to the OP, it's still a breakthrough. I'm not interested in making Gilead rich, I'm interested in whatever mitigation strategy works.
Sadly, many people will not use condoms for whatever reasons. If we are an empathetic world, those that can mitigate HIV through whatever strategies are available, are obliged to do so. This is my entire point. Post-infection strategies are as important as prevention.
Re: Oh well (Score:4)
I'm not interested in making them rich either. But ending HIV/AIDS requires ARVs, for both TasP and PreP, and Gilead makes a good chunk of them.
In other countries, even Western ones, ARVs cost a lot less. My Gilead branded Biktarvy costs $4000 at Costco without insurance, and 600 euros in France without insurance, for example. Of course, you would be hard pressed to not have insurance if you live in France.
I think all available tools should be used. Condoms are cheap, but rarely used consistently, and it only takes one mishap to get infected with HIV for life, whether it's one being forgetful, slippage, or breakage. One can also miss their daily PreP and lose protection. A twice a year injection, if it works, has much lower odds of losing the protection day to day. It is a breakthrough. But we cannot have everyone on shots costing $28k/year.
Also, I'm here to tell you that these ARV meds are not free of side effects. I'm part of ongoing litigation against Gilead for some long-term side effects of TDF / Truvada, which is used for PreP. It's still much better for me to take them than not, as I'm positive. But I would prefer meds with better side effect profiles. For people who are negative, the calculation may not be as clear as for me - the choice is to suffer long-term side effects of PrEP your entire life, and remain negative; or take the risk to become positive one day, and get on the meds only as necessary if that happens.
As far as responsibility, I happen to have protective genes that make me control HIV very well naturally - just not enough to avoid getting infected myself. I remained off meds for 5 years and was in clinical trials to help find these genes. Despite my excellent lab work - being nearly undetectable without meds - I had some fatigue, and decided to go on the meds when it became known that taking them cut the risk of infection to others to nearly zero. I had to drop out of the clinical trials at that point. A decade later, I suffered bone fractures and osteoporosis, in large part because of these meds. I could have kept using condoms instead and not suffered these side effects. Nowadays my body doesn't work the same way as before, and condoms are not an option anymore. I likely won't ever use one again. There is now DoxyPEP for STDs, which is not taken daily for life, and does not have long-term side effects, unlike ARVs.
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The reformulated Descovy is better than Truvada. DoxyPEP is also a great idea. My observation is that a combo of whatever works, statistically steepens the trajectory of infection and eventual mitigation/riddance.
The crisis could have an end; we agree that cutting science investigation costs more money, but also importantly quality of live over the long term.
And as a prophylactic, taking Truvada/Descovy doesn't have to be taken for life, rather, for as long as the risk is there in behavior and sex contact w
Re: Oh well (Score:4)
Yes, I switched from Truvada to Descovy as soon as it became available. There were however other combo meds with TAF available before Descovy.
Gilead sat on TAF development for a while, fully knowing about safety problems with TDF. They essentially withheld TAF until their TDF patent was close to expiration. There has been legal action about that, which I have not followed. By the time I got fractures, I was already on TAF for several years. I had never gotten my bone density checked before, though, as it is not normally ordered under 50. I had to insist to get it done after the fractures. My T-score was -4.0 .
I think we need something safer than even TAF, though. I'm glad HIV drug development continues, including PrEP. I'll be looking at the injections options myself if the safety profiles are better. But I'm wary of newly launched drugs due to lack of long-term data on side effects.
I wish all these drugs weren't so overpriced. Much of the excessive drug prices in the US doesn't go toward drug development, but rather to marketing & sales expenses, which are not allowed in other countries where national healthcare systems are the primary payer.
Re: (Score:2, Interesting)
I'm seeing Trump pull back on government funded research as a means to trim the federal budget.
C'mon, we all know this is BS, why are you repeating it? Trump (and his administration) don't care about "trimming the federal budget". They are ideologically opposed to many things the federal government does and are cutting those programs. Claiming that doing so saves the federal government money is clearly a smokescreen for their actual goals.
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Just one point: "free love" actually has a historical definition. It means that sexual activity should not be regulated by governments. That would also, technically, include the right to practice celibacy.
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"Free love" during the "sexual revolution" was about rejecting traditional, non-governmental, morals and prohibitions on sexual activity. It wasn't just "sex the government doesn't explicitly sanction in the institution of contract marriage", it was "sex without regard to consequences".
Sexual activity has inherent consequences, including physical, emotional, and spiritual consequences. Pretending that you can have sex "free" from consequences is one of the great lies of the 1900s.
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They really want this to be gods wrath for people doing stuff they don't want to admit they do out of sight
The arrogance of speaking for God. They don't even realize how hypocritical they are. And they want to "bring on" The Rapture. ROFL, God, if such an entity exists, will not submit to their "motivated" Rapture at their request. Or, maybe God will appear to do so because the timing is right anyways... but Christians can not "force" The Rapture. But they keep trying. Insanity.
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These things take time. People are often in denial about that. My condolences on your loss though.
How long until RFK Jr. tries to outlaw it? (Score:5, Funny)
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Amen!
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I stuck my worm in your mom's ass. Are we even?
Re:Lemme get on my soapbox for a second (Score:5, Informative)
Thanks for demonstrating that you are fucking idiot
mRNA vaccines are terrifically effective, do not rely on eggs for incubation (that is why avian flu is a threat) and will spawn the next generation of cancer treatments that will eliminate it as a common form of death
You are welcome to go somewhere else and spread your anti-vax lies, just make sure you are prepared to watch your loved ones die while everybody else enjoys their benefits
Re: (Score:1, Troll)
That was really convincing. For a long moment I thought you were serious! 8-)
Re: (Score:2)
big pharma and governmental oversight needs to be looked at.
I'll remind you that this was 100% overseen by the Trump administration. OOps. Start backpedaling in 3..2..1.. "But but but dear orange leader had no choice because some Democrat!!!"
Re: (Score:2)
"But but but dear orange leader had no choice because some Democrat!!!"
Some democrat? It is obviously Biden's fault.
Re: Lemme get on my soapbox for a second (Score:4, Insightful)
FWIW, shutdowns and mandates were done by the state. States rights are a thing and you, as a USA citizen, are welcome to relocate to a different state which did not implement draconian measures. The government worked the way it should have during this time.
Re: Lemme get on my soapbox for a second (Score:2)
Re: Lemme get on my soapbox for a second (Score:4, Insightful)
Re: (Score:1)
Uh oh. You triggered the big pharma dudes with mod points.
One day, our institutions will earn back their credibility. Today, is obviously not that day.
Relative Risk, not Absolute (Score:4, Informative)
The efficacy likely a wash or possibly harmful.
So how to you explain the significant lack of Covid hospitalization and deaths in those in the vaccine trails? The 95% efficacy was in stopping you getting any Covid symptoms, what mattered more was the massive drop in hospitalization and fatality rates amongst the vaccinated. You can recover from mild flu symptoms, it's a lot harder to recover from death. Yes, the vaccine was rushed out faster than normal because once the rate of significant reaction to the vaccine was under 1 in ~100,000 any harm from the vaccine was orders lower than catching Covid.
Any medical procedure can cause harm so if your criterion is that there is no risk of harm your only option is to never go to the doctor. The relevant question is whether the harm of the procedure is less than the harm caused by not getting it and for Covid vaccines the data show that catching Covid is overwhelmingly more harmful than any risk of harm from the vaccine.
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How deranged can you lying assholes get?
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The efficacy likely a wash or possibly harmful.
You're a genius and should be listened to. I mean not really, the reality is you're a fucking moron but since you set the bar for rejecting reality and substituting any old bullshit I'm going to do the same and sing your praises.
Re: (Score:2)
The propaganda worked and you are now hooked. Sad. :(
Stop listening to the talking heads bro. Start thinking for yourself. Anyone can prepare an argument for or against any particular thing and have it be a compelling argument. You have to THINK, and even then, you could be wrong, so continuously examine what you think and compare it against what you can test.
There are evil forces running about; especially since 1978, and they have all the energy in the world for deceiving you. Most everyone who can explain
Re:How long until RFK Jr. tries to outlaw it? (Score:5, Informative)
RFK, Jr, recently replaced all 17 members of the Advisory Committee on Immunization Practice (ACIP) at the CDC with (so far) 8 new members, including Dr. Robert Malone who has said that the COVID-19 vaccine could cause AIDS.
From: Vaccine Skeptics Among CDC Vaccine Panel Replacements Named by RFK Jr [ajmc.com] and Google: malone vaccine cause aids [google.com]
Malone has also previously said that the COVID-19 vaccine could cause a form of AIDS and that Americans were hypnotized into getting vaccinated.
Just wait until they confuse SMNP with SNMP (Score:2)
Now you're just being silly (Score:2)
This is why RFK Jr is in charge of Health and human services and you're not. Well that's and you didn't run a presidential campaign off of your family's good name and then use it to score a sweet cabinet position by selling the endorsement out.
For the snowflakes (Score:1)
Who are going to moan about why we need an HIV vaccine think about this. What makes you think it will only work on HIV? We could turn it loose on any number of viruses.
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Who are going to moan about why we need an HIV vaccine think about this. What makes you think it will only work on HIV? We could turn it loose on any number of viruses.
I would not expect this to work with anything other than HIV because a vaccine for one strain of COVID-19 will fail to protect against a very closely related different strain. The same goes for the seasonal flu shots, if the people making the shots guess wrong on which flu strains are "popular" that season then they will fail to protect the population from the flu.
I used to get a really bad flu nearly every year up until I got to be 20 years old or so. Since then I'd still get a flu here and there but it
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>>I got my two COVID-19 shots but I still ended up testing positive for COVID-19 twice. That sucked as it was more like four days of being a lump on the couch than just one. If I was told which variant of the virus I had then I don't recall.
And yet, you are not dead... so the vaccines you took were effective. As far as your other claims... nobody is trying to claim that the HIV vaccine will be used on other diseases, BUT that the techniques used to create the vaccine will be
On one hand, the fact that
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And yet, you are not dead... so the vaccines you took were effective.
The claim was that the vaccine would prevent infection, when that proved wrong the goalposts were moved to claim it was to reduce the symptoms.
Since so few people died from COVID-19 in the first place it is difficult to know if any of the vaccines did anything helpful. Well, that's "few" as in less than 1% of the population of those infected with that first wave of the deadliest strains, and most of those that died were over 75 years of age. My risk of death was quite small to begin with so it's hardly pr
Re: (Score:3)
The goal was always that the vaccine would reduce the rate of death in the general population from a novel virus that they did not have any related immunity for
NOBODY was selling a 100% reduction in infection, and you claiming that is just "moving the goalposts" , if I could be so bold as to quote your hypocritical self
Go back to 4chan pol and get praises from your buddies, nobody here is buying what you are shilling
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Any disease can do that too.
Biology is just a shitty way to run a conscious mind.
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Biology is just a shitty way to run a conscious mind.
But cheap and easy to make. The only reason why it is a (limited) success.
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Why is this post downmodded? Seems more on topic and appropriate than all the stupid Trump posting.
Re:oh god (Score:4, Informative)
Because it was loony. Dude espoused an amazingly false understanding of the purpose and functionality of adjuvants.
The way our immune system works is that co-factors are usually needed to alert it to the presence of new dangers. Because usually, in nature, whenever a foreign agent is inserted into the blood, it's never a single agent. For example, if a bacteria enters the blood .. it has various lipids and other metabolites simultaneously. That causes multiple parts of the immune systems to activate in a synergistic manner. The adjuvants is a way of telling the immune system that the vaccine (which consists of parts of the virus or pathogen) .. "this is enemy". Let me give you a specific example: You can eat all the beef .. which contains a substance called "alpha-gal" you want. But if you get bitten by a tick that recently bit a cow, specifically the Lodestar Tick, you will forever be allergic to beef (alpha-gal syndrome -- look it up). Because the tick injected alpha-gal (from the cow) alongside all the tick specific junk. That acts as an adjuvant to the alpha-gal .. and specifies alpha-gal as your bodies enemy. If a person gets alpha-gal in their blood any other way, they likely won't get allergic. It needs to be injected alongside an adjuvant. Vaccines too are the same way. Since vaccines are just fragments of a pathogen, a adjuvant is needed alongside it so that the body realizes it has to make itself immune to the vaccine's proteins. Summary: A vaccine's job is to make your immune system react to pathogenic substances -- the immune system won't take the bait unless it sees more than just some protein fragments presented to it.
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typo: Lonestar Tick
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That actually lines up with most of what he's saying. His claim is that the vaccine mentioned in the summary is going to cause the immune system to over-react.
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The OP misrepresents adjuvants as something new ("in modern vaccines") that will cause dramatic problems ("god help the poor schmucks") and vaccines to fail safety trials ("It is never coming to market"). While adjuvants are old and tried. Of course, "there is no doubt that safer adjuvants need to be developed and incorporated into future vaccines" (says DOI:10.1177/0961203309345724). But OP is needlessly alarming, which is why it gets downvoted.
Re: (Score:3)
Saying "we got a vaccine that works by loading it full of adjuvants" is another way of saying, god help the poor schmucks who participate in the future safety trial. It is never coming to market.
Immunological adjuvants are in use for a century, initially named in 1923 by veterinarian Gaston Ramon https://en.wikipedia.org/wiki/... [wikipedia.org] following his studied on horses used to produce diphtheria antitoxin (= antibodies). His methods to manufacture diphtheria and tetanus vaccines are still used today.
Did anyone else read "SNMP"? (Score:2)
I had to read more closely to see that didn't say what I thought it said. From the Scripps article: A second strategy employed saponin/MPLA nanoparticles (SMNP).
Re: Did anyone else read "SNMP"? (Score:2)
Here too
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It actually was a bit of a search to find "SMNP", so my original post was both a commentary on how our eyes tend to see what we expect, and to provide the acronym expansion for the lazy among us...
The timing couldn't be worse (Score:5, Interesting)
By the beginning of Trump's third term you will have to travel to Europe or Mexico or Canada to get a vaccination.
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I could get total admin support with one sentence:
"Mr. Trump how would you like to go out in front of crowds and say 'I cured AIDS'"? He'll probably ask for the biology Nobel!
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trump is supported by the Heritage Foundation, a fundamentalists, right -wing group that believe HIV is gods punishment for doing naughty things
What trump will do, is make these treatments available only for the rich, while leaving the masses to spends millions of half-cures or die when their medicare is cut
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See I don't believe Trump actually cares about heritage beyond their loyalty and political support. If he actually wanted to shift gears they would follow him, the entire conservative establishment is servile.
Also this is HIV which isn't that something that is as politically dividable as covid or childhood vaccinations so there wouldn't be as much opposition. A normal human being might call that hypocritical but these people have no sense of that or shame anymore. The narrative is all that matters.
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A little history would help
Reagan refused to address AIDs epidemic because... God's Punishment
The Heritage Foundation were around back then, and supported Reagan
Trump relies on Heritage Foundation support to keep power, and power is the only thing that matters to him
As a result, expect to get Heritage foundation lies shoved down your throat as long as trump is in power
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Trump ain't Reagan and this isn't the 80's
If this was say Ted Cruz I would agree but Heritage answers to Trump, not the other way around. The reason they get influence is Trump can't be assed to come up with actual positions on most issues because he does not care so Heritage get's to do that so long as he doesn't object, but if he does they will cowtow, they all do. The party *is* Trump now.
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Sure, keep telling yourself that, and then maybe you can also ignore the enduring influence of the Koch network in trumps slavish support for fossil fuels.
trump thinks he is playing them for money, but they are making a hundred times as much profiting from his actions, from creating trading opportunities in the stock market with tariff threats, to instant increases in oil prices after Iran "intervention"
Don't get me wrong, imo trump is as close to The Golgothan [youtube.com] as we could see, but ultimately he is as contr
That isn't curing AIDS (Score:2)
To the kind of person in the 46 to 47% who currently support Donald Trump in spite of everything you can't cure something that you aren't suffering from. Everything has to be dramatic to those people. So you have to have somebody who very very very very obviously has AIDS and is dying from it and then gets better like magic. That's curing.
Those people
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He doesn't care. It wouldn't be going to his supporters for the most part, and some of the more vocal ones will criticize him for it.
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So you are all right with the payoffs from Pharma?
"Seven other panel members received between $4,000 and $55,000 from drugmakers for consulting, speaking fees, travel or meals over the period 2017 to 2023. Two of those experts had also worked with other scientists in industry-funded research projects worth several millions of dollars."
https://www.reuters.com/busine... [reuters.com]
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Sure, but first there's nothing in there that shows an evidence of wrongdoing and second are Kennedy and Trump changing rules and laws that would prevent this from happening? Has his picks taken plednges to not take any consulting gigs or do any research or anything at all with biotech firms?
Something smells like selective outage and just replacing one conflict of interest with a different one.
https://www.npr.org/sections/s... [npr.org]
In fact, Meissner, a professor of pediatrics and medicine at Dartmouth College's G
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Besides that, we all know all the vitamin and supplement industries are beyond reproach.
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MIT and others will have to realize they need to move their research (and probably rest of their organization) out of the US. They are currently in denial about this, but eventually they will see it.
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By the beginning of Trump's third term you will have to travel to Europe or Mexico or Canada to get a vaccination.
You are so wrong that it is not even funny. No other country will accept an unvaccinated person crossing their borders. We will become North Korea, not the Philippines.
(thought I was gonna make it about the "third term" thing didn't you)
Too bad Trump Cancelled the lab funding (Score:5, Informative)
President Donald Trump cut the lab funding.
https://spectrumnews1.com/ca/s... [spectrumnews1.com]
You can't make a vaccine without trials and without labs.
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President Donald Trump cut the lab funding.
https://spectrumnews1.com/ca/s... [spectrumnews1.com]
You can't make a vaccine without trials and without labs.
Correction, the US can't.
Germany, Belgium, Denmark and the UK would jump at it. Modern pharmaceuticals are one thing that we can't produce well outside the developed world.
Welp, enjoy your science harvest while you can (Score:2)
Cause this shit ain't going to last. With Trumpkins cutting off the science funding, we're just gonna get another year or two of breakthroughs before the well dries up. Hopefully all the scientists going to other countries will do good work. My PhD cousin is looking for his postdoc 100% outside of America.
Just add soap! (Score:3)
"This molecule naturally joins together with saponin molecules to form saponin/MPLA nanoparticles (SMNP).
At LJI, Scientific Associate Yu Kato, Ph.D., started by spearheading experiments to understand exactly what makes saponin adjuvants effective.
Experiments in mice showed that a saponin adjuvant triggers a strong response from the body’s germinal centers, structures in the lymph nodes that pump out B cells. A saponin adjuvant also led to better T cell and class-switched antibody responses (which allow antibodies to switch targets as they develop), compared with a range of alternative adjuvants."
If you've forgotten your chemistry, "Saponification involves a reaction between a fat or oil (which are esters) and a strong base, such as sodium hydroxide (NaOH) or potassium hydroxide (KOH)."
Trump was on the right track with the injecting bleach thing. Soap and water was the right answer all along. ;-)
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Re:Just add soap! (Score:4, Interesting)
It's called "soap tree" because a solution of the extract makes foam, like soap. This is not, however a saponified fat or an alkali that will saponify fat. It is a molecule with a hydrophilic part tied to a lipophilic part.
Another example from pharmacy is the common blood pressure drug olmesartan/medoxomil, where lipophilic olmesartan is tied to hydrophilic medoxomil, with an interesting bridge. The bridge is diacetyl, aka butter popcorn artificial flavor. Sniff a bottle of Benicar (or generic) tablets, and if your nose is as sensitive as mine to diacetyl, you'll smell it.
One Shot (Score:5, Funny)
Great! Hand all the right-wingers hypodermic dart rifles loaded with this stuff. Tell them to go hunt LGBTQ+ people and addicts. Everyone is happy.
Probably won't get approved for use in the US (Score:2)
Considering the current anti-science, anti-vaccination regime in the US, it will be difficult to get this vaccine approved.
Politics (Score:2)
And to think, I came to the comments to actually see if there were some insightful posts addressing some questions I have about this new technology/method, and if not, post questions. And what I find is pretty much all the same political crap every time vaccines come up.
So I guess there is no point asking :(
Re: (Score:2)
Your low UID is showing, Reddit is where sincere, moderated discussions are going on. /. is a culture war shitshow these days, not that I am opposed to it considering the 'opposition' is pure Idiocracy
IMO, it has never recovered from the Dice days and attempts to monetize it, but I still show up to tell shills to get offa my lawn
whew! (Score:1)
Now gay men can go back to all that irresponsible behavior they practiced before HIV!
Next stop: monkey pox.