Is There a Brain Microbiome? 6
An anonymous reader quotes an opinion piece from The Guardian, written by Prof Mark Pallen and Dr Aimee Parker (Quadram Institute, Norwich), Prof Nick Loman (University of Birmingham), Prof Alan Walker (University of Aberdeen): Contrary to what is implied in [this article], the weight of expert opinion in medical microbiology rejects the existence of a "brain microbiome" in the sense of a resident microbial community in healthy human brains. While pathogenic microbes -- such as Borrelia burgdorferi, which causes Lyme disease, or fungal pathogens like Cryptococcus neoformans -- can invade the brain and cause neurological symptoms, these are examples of infections, not evidence of a native microbial community.
Similarly, cognitive benefits of vaccines can be explained by their role in preventing infections or modulating immune responses and inflammation, rather than any impact on a "brain microbiome." Furthermore, the studies cited in the article have not undergone independent validation, nor do they provide any kind of consistent picture. This mirrors controversies around other supposed microbiomes -- such as that of the placenta -- which have failed to withstand independent scrutiny. Over a decade of research indicates that contamination, typically from laboratory reagents, is the most plausible explanation for such findings, particularly when even supposedly ultrapure water has been shown to harbor DNA signatures and culturable microbes.
If diverse microbes are truly abundant in the brain, why have they not been repeatedly and consistently cultured in over a century and a half of medical microbiology? Why have they not been observed in numerous microscopy studies of human brain tissue? Efforts to explore overlooked roles of microbes in neurological conditions are welcome, but they must be grounded in robust and reproducible science -- not speculative discussion of a "brain microbiome." In the article mentioned above, author Amy Fleming discusses the emerging research connecting infections such as Borrelia, Cryptococcus, and herpes viruses to reversible dementia, challenging the long-held belief that the brain is sterile.
She highlights the Alzheimer's Pathobiome Initiative, which investigates how brain infections may contribute to diseases like Alzheimer's, with the goal of developing new diagnostic tools and treatments. Vaccines like BCG and zoster have shown protective effects, while good hygiene, oral health, and a healthy lifestyle can help reduce risks.
Similarly, cognitive benefits of vaccines can be explained by their role in preventing infections or modulating immune responses and inflammation, rather than any impact on a "brain microbiome." Furthermore, the studies cited in the article have not undergone independent validation, nor do they provide any kind of consistent picture. This mirrors controversies around other supposed microbiomes -- such as that of the placenta -- which have failed to withstand independent scrutiny. Over a decade of research indicates that contamination, typically from laboratory reagents, is the most plausible explanation for such findings, particularly when even supposedly ultrapure water has been shown to harbor DNA signatures and culturable microbes.
If diverse microbes are truly abundant in the brain, why have they not been repeatedly and consistently cultured in over a century and a half of medical microbiology? Why have they not been observed in numerous microscopy studies of human brain tissue? Efforts to explore overlooked roles of microbes in neurological conditions are welcome, but they must be grounded in robust and reproducible science -- not speculative discussion of a "brain microbiome." In the article mentioned above, author Amy Fleming discusses the emerging research connecting infections such as Borrelia, Cryptococcus, and herpes viruses to reversible dementia, challenging the long-held belief that the brain is sterile.
She highlights the Alzheimer's Pathobiome Initiative, which investigates how brain infections may contribute to diseases like Alzheimer's, with the goal of developing new diagnostic tools and treatments. Vaccines like BCG and zoster have shown protective effects, while good hygiene, oral health, and a healthy lifestyle can help reduce risks.
Ya ... (Score:1)
Is There a Brain Microbiome?
RFK, Jr. calls it worm food. :-)
[Though, his is dead, so the quality is suspect. There might need to be a recall.]
Not the Same Thing (Score:1)
RFK, Jr. calls it worm food. :-)
That's an example of a microbrain biome which is not the same thing as a brain microbiome.
Brain Hurts (Score:2)
My brain hurts just reading this. Can I get something for that doc?
--
America's health care system is neither healthy, caring, nor a system. - Walter Cronkite
No (Score:1)
Jury still out (Score:2)
From all I have read, it is highly unlikely that anything equivalent to the microbiome in our digestive tracts exists in the brain. However, the presence of a limited group of protective organisms seems plausible. As hinted by TFA, circumstantial evidence suggests conditions like Alzheimer's are affected by gut bacteria. The most likely reason for such an effect seems those organisms crossing the blood brain barrier and acting directly within the brain. Really, though, we simply do not know yet.
So poor experiments result in no data? (Score:2)
So the researchers do not know how to do experiments properly and hence they mistrust their own studies and then say "there is no evidence". Gather some f'''ing evidence then! The article names several microbes that can reach the brain, COVID-19 i