'Supermodel Granny' Drug Extends Life In Mice By 25%, Study Finds 95
A drug has been shown to extend the lifespan of laboratory mice by nearly 25%, with treated mice displaying fewer cancers and improved health and strength. It earned them the nickname "supermodel grannies" due to their youthful appearance. "The drug is already being tested in people, but whether it would have the same anti-ageing effect is unknown," reports the BBC. From the report: The team at the MRC Laboratory of Medical Science, Imperial College London and Duke-NUS Medical School in Singapore were investigating a protein called interleukin-11. Levels of it increase in the human body as we get older, it contributes to higher levels of inflammation, and the researchers say it flips several biological switches that control the pace of ageing.
The researchers performed two experiments. The first genetically engineered mice so they were unable to produce interleukin-11. The second waited until mice were 75 weeks old (roughly equivalent to a 55-year-old person) and then regularly gave them a drug to purge interleukin-11 from their bodies. The results, published in the journal Nature, showed lifespans were increased by 20-25% depending on the experiment and sex of the mice.
Old laboratory mice often die from cancer, however, the mice lacking interleukin-11 had far lower levels of the disease. And they showed improved muscle function, were leaner, had healthier fur and scored better on many measures of frailty.
The researchers performed two experiments. The first genetically engineered mice so they were unable to produce interleukin-11. The second waited until mice were 75 weeks old (roughly equivalent to a 55-year-old person) and then regularly gave them a drug to purge interleukin-11 from their bodies. The results, published in the journal Nature, showed lifespans were increased by 20-25% depending on the experiment and sex of the mice.
Old laboratory mice often die from cancer, however, the mice lacking interleukin-11 had far lower levels of the disease. And they showed improved muscle function, were leaner, had healthier fur and scored better on many measures of frailty.
Why? (Score:5, Funny)
Why would we want longer living mice with improved health and strengtth? Are they trying to make a new end boss? Imagine an entire colony of these new and improved mice coming out of the walls of a small room you're in.
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Rather than living longer, I'd rather have better quality of life with the time I have.
A study recently reported that a beer a week can take a couple of months off your lifespan. Seems like a very good deal to me.
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Rather than living longer, I'd rather have better quality of life with the time I have.
it would make sense that the latter brings the former.
A study recently reported that a beer a week can take a couple of months off your lifespan. Seems like a very good deal to me.
if that were a consistent trend i should be long dead by now.
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Rather than living longer, I'd rather have better quality of life with the time I have.
it would make sense that the latter brings the former.
A study recently reported that a beer a week can take a couple of months off your lifespan. Seems like a very good deal to me.
if that were a consistent trend i should be long dead by now.
And that's the part that I find fascinating about those type of studies. They are utter bullshit when they try to quantify your likely death based on how many cigarettes, beer, exercise or (fill in the blank) you have partaken on.
Life is too short to spend all our time trying to squeeze out a few extra years. All of those years an the old and deteriorated end for that matter.
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I will happily take any and all of those "end of model" years you might choose to have left over...
I want to go on for as long as I possibly can.
Hell, if I could get bit by a vampire and be immortal, I'd go for it immediately.
Hmm...well, if I had the choice, I'd like to lose a bit of weight first, so I don't go through eternity this overweight....but hey, be
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Agreed. It's all well and good to talk with ease about going to oblivion when ones health is good, most dont seem to hold the same opinions though when they are dying or if they do it's often because they've destroyed their bodies via poor living and thus have nothing to live for.
After years of poor living those in poor health are rarely ready to go when death comes knocking early though.
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Agreed. It's all well and good to talk with ease about going to oblivion when ones health is good, most dont seem to hold the same opinions though when they are dying or if they do it's often because they've destroyed their bodies via poor living and thus have nothing to live for.
After years of poor living those in poor health are rarely ready to go when death comes knocking early though.
Different strokes for different folks.
And the concept that people are responsible for their infirmities. Allow me to give the example of my Mother in law. A devout lady, never smoked, never drank. Took care of herself. She should have been a shining example. But she became demented in her late 60's. Was in a nursing home the last 12 years of her life.
She thought my wife was her mother, became foul mouthed and racist. Thought the "fucking Chinese" were always stealing her TV remote control. And the fi
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And the concept that people are responsible for their infirmities. Allow me to give the example of my Mother in law. A devout lady, never smoked, never drank. Took care of herself. She should have been a shining example. But she became demented in her late 60's. Was in a nursing home the last 12 years of her life.
Absolutely people arent 100% responsible for their infirmities, I was never arguing that point. Given the poor way most are treating their bodies in this country though https://www.cdc.gov/obesity/ph... [cdc.gov]. plenty seem to be going out of their way to create new ones for themselves or bring what they're predisposed to on themselves sooner.
Making long term health choices so the odds are strong one has plenty of healthy and happy retirement years is just good long term planning. I want to be healthy and happy in
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I will happily take any and all of those "end of model" years you might choose to have left over...
I want to go on for as long as I possibly can.
Oh, I do get the sentiment. We're all involved in life based on our temperament and experiences. A friend of my wife's brother was dying of terminal cancer. He was in a lot of pain, but he held on long after there wasn't much point, as the cancer eventually entered his bones. At that point, it is damn hard to manage pain. But he wouldn't let go until he more or less just rotted. To me, his will to live was strong, but over broad. Bedridden and in pain, and doing nothing but lying in bed, I guess he found t
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Rather than living longer, I'd rather have better quality of life with the time I have.
it would make sense that the latter brings the former.
Only if your time is not spent in misery. If life as an adject horror-show, filled with days of misery and pain, or constant existential crises, extending it isn't improving your quality of life at all. It's just extended misery.
A study recently reported that a beer a week can take a couple of months off your lifespan. Seems like a very good deal to me.
if that were a consistent trend i should be long dead by now.
Amen.
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Rather than living longer, I'd rather have better quality of life with the time I have.
A study recently reported that a beer a week can take a couple of months off your lifespan. Seems like a very good deal to me.
So much this. The problems with "life extension" is that if and when it works, all of the extension is on the old end of life.
If I had, say, another 20 years on my 30's, then return to normal aging - yeah - sign me up. If all life extension gets me is more years of being old - miss me with that.
Re:Why? (Score:4, Insightful)
At a younger age it is easy to believe that all old people are this or that, but once you hit old age, well, people are all different and all old people don't spend the last years of their lives in care and unable to do things that they enjoy.
This is not to say that I want you to do x or y, no I just hope that you live to a ripe old age and also enjoy every minute of it, dying with a smile on your facw, as you fight the Grim Reaper every step of the way.
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It's hinted at in the summary but confirmed in the article itself, this drug is effecting health and well being as well as longevity which only makes sense. How would something make someone live longer without improving well being after all?
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I don't know. There are some beers that I would want to have a much more drastic effect on my lifespan if I had to drink one of them a week :)
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Or...maybe look at it another way.
The longer you live, the MORE beer you can drink!!!
Hey, I don't care if I have to get a shot or bit by a vampire, if I could stop aging now and live forever (or at least almost) I'll take that bargain NOW.
I love living....
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Re:Why? (Score:5, Insightful)
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Yep, same here. Although one a week? That seems to be exceptionally speculative. I am currently running a long-term experiment with a little less than one a day. So far, so good.
My take is that all these "longer life" people are simply deeply afraid of dying and non-rational enough to be able to suppress the fact that dying later still means dying. I do not get that at all. Everybody dies and you cannot actually fail at it. It is not a test where, if you screw it up, you are damned to live forever. Hence it
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Wow...do you really have such little sense of self-preservation?
That misinterpretation says a lot more about you than about me. And it has nothing to do with self-preservation. Competent self-preservation takes cost of measures vs. quality of outcome into account. Otherwise you could live as lot longer and be miserable along the way. I fail to see how that is desirable.
I am scared to death of dying....I know it's coming, but I'm more than willing to do anything possible to push it as far off as humanly possible.
Well, I am not. I think I have done a good job for myself, and dying is, as I said, not something you can fail at. Hence no rational reason to be afraid of it. Obviously, countless religions and quasi-re
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My take is that all these "longer life" people are simply deeply afraid of dying and non-rational enough to be able to suppress the fact that dying later still means dying. I do not get that at all. Everybody dies and you cannot actually fail at it. It is not a test where, if you screw it up, you are damned to live forever. Hence it is actually not that scary. Personally, I see myself already in the "bonus area" for this life. I have developed my skills, insights, knowledge and intuition to most of their potential.
Wtf are you even talking about here? People are afraid of dying because odds are it's the end of their consciousness, as in they will no longer exist. Unless your life is utter shit any rational person would chose life over death hence people working to preserve their health. Where are you even getting this nonsense "well you cant fail at it so who cares when it happens"? Maybe your life is just so empty that you're welcoming death, I cant know that. What you describe is hardly normal thoughts on the subjec
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Wtf are you even talking about here? People are afraid of dying because odds are it's the end of their consciousness, as in they will no longer exist.
What odds? You should not listen to religions like Physicalism. Incidentally, fear is always a bad advisor. Even if death of the physical body is the end of consciousness (which we do not know and there are some pretty good indicators it may not be), so what? Living in fear is living badly.
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If you cant grasp the uncomfortableness living people have with their own mortality all I have to say to you is have fun with that robot. I dont think that's true though, I honestly think you're just deluding yourself.
Living in fear is living badly.
Gotta love your dishonestly. Notice when I clearly stated: "fear of death is a perfectly rational fear to have if held within good measure."
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A study recently reported that a beer a week can take a couple of months off your lifespan. Seems like a very good deal to me.
Depends on the beer. :-)
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A study recently reported that a beer a week can take a couple of months off your lifespan. Seems like a very good deal to me.
A good deal until you find out the months are taken from the quality portion of your life, not the end.
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i for one welcome our new rodent supermodel granny overlords!
Re:Why? (Score:4, Funny)
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>Why would we want longer living mice with improved health and strength.
It says they're more attractive, too.
After all *you* wouldn't want to be stuck with an ugly one, now would you?
Mouse Oil (Score:1)
False hope is a bitch.
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But you can make tons of money selling it to rich unsophisticated assholes that cannot handle the idea of dying.
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individuals have to show some level of achievement or merit to extend lifespan (i.e., pay for the treatment), then on the whole you have more merit-based society.
that's as wishful as thinking can get.
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> merit-based society
and that's ethical dilemma as some are less genetically equipped than others so their raw capabilities differ, for this to work ethically, it would have to be somehow relative to these raw capabilities
Re:Demographics is fate (Score:5, Insightful)
Re:Demographics is fate (Score:5, Insightful)
Instigate a 100% inheritance tax with the proceeds going into education and you get a lot closer to merit bringing money.
Re:Demographics is fate (Score:4, Insightful)
Instigate a 100% inheritance tax with the proceeds going into education and you get a lot closer to merit bringing money.
Such plans are only good on paper, in practice you are going to penalize top 10% without affecting 0.1% at all, making the problem worse. Direct inheritance of wealth is only one aspect of generational transfer of power. Look at Bush or Cheney families as an example, you have kids inheriting tremendous power from previous generation and there is no way to tax that. You can always convert power into money as needed, but doing so inherently corrupts the system.
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So, when everyone has $5M due to inflation? (Score:4, Insightful)
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"Wealthy" is when you could lose your job, never work again, yet maintain a lifestyle that includes never being hungry, or lacking shelter, medical care, or clothing until you die due to old age.
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It's perspective. Have a look around your broader community... There are going to be people worried about getting food, paying rent and never sure if they'll have enough to keep doing so, etc.
You're wealthy, you just aren't aware of it because you're comparing yourself to people who have even more than you do.
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The fact that people work hard to take advantage of a system that is currently in place does not make the system good. If you want to have some small degree of transfer to ensure basic needs can be met short-term while t
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So, we're going to help the middle class by this death tax?
How?
You expect that giving the government all this money from no more inheritance...is somehow going to spread out and lift up the middle class?
This government? With its spending his
Re:Demographics is fate (Score:4, Insightful)
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Or ban poor (and stupid) people from breeding. It is no human right to force children to grow up in misery (material or intellectual).
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I could ever LONGER free time retirement years?
PLEASE sign me up!!!
If you're not interested, I'll be happy to take your leftover pensioner years, no problemo.
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It is 67yrs for me....
At least for "full" Social Security benefits...you can retire at 62 years I think, but you're giving up a lot of $$ that way.
With people living longer, I could see the raising of the age a bit when they did...but I don't see that as really being something to do a
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A rich guy I knew back in the 80's was very noisy about Social Security and Medicare... he thought that he, as a rich guy who had paid into them his entire life
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Then again, we're also slowly and unwillingly rolling towards the realization/admission that automation in the west is quickly moving towards the point where it's no longer realistically possible to expect everyone to work 40 hours a week unless you include obviously "fake" make-work jobs.
What are we going to do as the advancement of machine technology causes the available spectrum of jobs to ever more dramatical
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Considering how much demand for life-extending treatments there is, it is only matter of time until one is produced. This is a positive development, as Global demographics see drastic population declines in the developed world.
Unless these life-extending treatments enable super grand humans to fuck like rabbits and replicate, this is not going to solve the population decline problems. Japan has a lot of old people. What they desperately need is the grandchildren that are usually around by now to not only help care for the elderly but procreate and provide the next generation. (Adult diapers have outsold children’s diapers in Japan for the last decade to give you an idea of the growing problem.)
Personally, I see life-extending treatments as one possible stop-gap measure against slide toward Idiocracy. If individuals have to show some level of achievement or merit to extend lifespan (i.e., pay for the treatment), then on the whole you have more merit-based society.
Yeah, or the insane amount
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And that’s before we consider super grand humans living a LOT longer suffering with dementia and Alzheimer’s. Article was rather light on addressing our most difficult challenges. Humans may ultimately not even want to live longer if those outcomes are inevitable.
Few people actually want to die. But that said, you are spot on. Who would want to spend 15 years in "memory care" because the drug they were taking made certain they remained alive.
The other observation is that while we have extended average lifespan in general, it all feels too short. Of course it will, because we get used to things. It will feel just as short to them as well.
I think Hunter Thompson said it best:
"Life should not be a journey to the grave with the intention of arriving safely in a p
Re:Demographics is fate (Score:4, Insightful)
I think Hunter Thompson said it best:
"Life should not be a journey to the grave with the intention of arriving safely in a pretty and well preserved body, but rather to skid in broadside in a cloud of smoke, thoroughly used up, totally worn out, and loudly proclaiming "Wow! What a Ride!".
I very much agree. Still, this is not the same thing as live short and die young.
Imagine if you could have family, kids and focus on that for the first 40 years and then have productive career for the next 60 and then 20 years of retirement. Currently, big part of the problem for demographics is that people have to choose between family or career. Extra 20-30 healthy years at the tail end of life could easily solve that.
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I think Hunter Thompson said it best:
"Life should not be a journey to the grave with the intention of arriving safely in a pretty and well preserved body, but rather to skid in broadside in a cloud of smoke, thoroughly used up, totally worn out, and loudly proclaiming "Wow! What a Ride!".
I very much agree. Still, this is not the same thing as live short and die young. Imagine if you could have family, kids and focus on that for the first 40 years and then have productive career for the next 60 and then 20 years of retirement. Currently, big part of the problem for demographics is that people have to choose between family or career. Extra 20-30 healthy years at the tail end of life could easily solve that.
Uh, this assumes humans will be the employable asset in the future to sustain a 60-year long career. Going to be hard to do when Greed running corporations starts advertising for jobs that are 24/7/365 and has a whole new definition of “productive”.
At the current rate of greed I don’t even see 60 years left for most human jobs. And before even more assume UBI will be some kind of utopia, UBI will be nothing more than welfare with a fancy name in order to sell it.
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I think Hunter Thompson said it best:
"Life should not be a journey to the grave with the intention of arriving safely in a pretty and well preserved body, but rather to skid in broadside in a cloud of smoke, thoroughly used up, totally worn out, and loudly proclaiming "Wow! What a Ride!".
I very much agree. Still, this is not the same thing as live short and die young. Imagine if you could have family, kids and focus on that for the first 40 years and then have productive career for the next 60 and then 20 years of retirement. Currently, big part of the problem for demographics is that people have to choose between family or career. Extra 20-30 healthy years at the tail end of life could easily solve that.
Uh, this assumes humans will be the employable asset in the future to sustain a 60-year long career.
This touches on one of the big mistakes young people have. The concept that they'll never retire.
Well, in many cases, they aren't the ones who decide. The employer is.
I'm an outlier in this. I retired early and then after some folks found out, I went back to work part time.
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And, sometimes, your body can decide you retire before you OR your employer does.
Different things can go wrong health wise...and especially so, if your work depends upon your physical movements (lifting, hammering, etc).
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Given that 120 years.....I think I'd chose to party for 120 years....
But, that's just me.
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I used to believe that. Truly. Then I saw many an old person simply giving up on “modern” society. Feminism promoting masculinity in the worst way. Gender quantities exploding because feelings. Divorce rates skyrocketing even among lesbian couples, while real men are shamed and shunned as “toxic” in society. Women not being able to define what a “woman” is anymore.
I think a lot of old people now do NOT want to live longer to simply feel that much more incompatible.
Those problems are self correcting in the end. almost half of women are forecasted to be single and childless in a few years. (2030) And I expect the problem is worse than that.
The whackiest thing is by trying to convince men that men should be the emotional equivalent of women, the present day mantra of "emotional availability" that many of the ladies complain about leads them to be repulsed by men who buy into it and act all emotional for the ladies. Or if not repulsed, a new member of the friend zone.
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Those problems are self correcting in the end.
I fully agree. While the harm is going to be lasting, the problem will not continue lingering on. Excesses of feminism already subsiding, excesses of trans ideology making their way through the courts via lawsuits, and companies just started to eliminate DEI departments. We are well into correction period and likely to have good decade or so. Until the next bullshit crawls out of radical cesspool somewhere. If anything, I think the next BS going to come from the right this time due to how thoroughly discred
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Those problems are self correcting in the end.
I fully agree. While the harm is going to be lasting, the problem will not continue lingering on. Excesses of feminism already subsiding, excesses of trans ideology making their way through the courts via lawsuits, and companies just started to eliminate DEI departments. We are well into correction period and likely to have good decade or so. Until the next bullshit crawls out of radical cesspool somewhere. If anything, I think the next BS going to come from the right this time due to how thoroughly discredited the left ideology is at the moment.
A pretty good assessment. One of the most insane things we have is the far left and far right acting like brain dead asses, and whoever is in the middle - they try to assign to the other side if they don't agree.
Looks like some biology denier got triggered, and went about proving me correct. Amazing that someone would stalk so hard be so spittle drooling angry and with that righteous rageboner, take the time to waste their mod points on all my posts here. geekmux, sinij and myself are having a simple and civil conversation.
I've always been clear that I have no issues if a person wishes to dress and live as the opposite sex, even to the point of some invasive procedures. But trying to claim that the person is a
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The wackiest part about the problems you’ve described, is they all stem from the lies of “modern” feminism. Women do eventually realize how bad it has become. Problem is that usually happens only after they realize how bad the lies have screwed their chances of long-term happiness.
Perhaps society will start caring about men’s suicide when the female suicide rate exceeds it. It’s sadly going to be quite the mindfuck as the younger generation ages and realizes they’ve pu
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The wackiest part about the problems you’ve described, is they all stem from the lies of “modern” feminism. Women do eventually realize how bad it has become.
Happening now. We're seeing a lot of online vids and rants asking "Where have all the good men gone?"
Multiple problems there - So many women have extended their "wild oats" stage until their mid 30's, and so many have chosen the so called "bad boys" because they are a source of tingles. The show Sex and the City was misread as a life planning guide, not just entertainment based on promiscuous women.
The problems are many - the guys they bang are not marriage material for the most part. Indeed, they ar
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It might be a dictator deciding which race lives or dies off.
This is already a possibility without any kinds of life-extending treatments.
And that’s before we consider super grand humans living a LOT longer suffering with dementia and Alzheimer’s.
This is absolutely a problem, but I think it is solvable. For example, if you are on life extending treatments you are ineligible for any kind of government assistance other than medically assisted dying past age of 85.
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Unless these life-extending treatments enable super grand humans to fuck like rabbits and replicate, this is not going to solve the population decline problems.
Population decline is not a problem... it's not even happening in terms of the global population.
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It's happening across the Western world....you know, the part that matters?
Re: Demographics is fate (Score:2)
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Considering how much demand for life-extending treatments there is, it is only matter of time until one is produced. This is a positive development, as Global demographics see drastic population declines in the developed world.
Nope. Letting people age more will do exactly nothing to cope with demographic effects (the ageing society). On the contrary, it will make the ideal population pyramid even more onion- or even upside-down-pear-like. What mankind needs are young people, and allowing a small fraction of wealthy people to live longer will be counterproductive. I think it goes without saying that an effective anti-ageing medication will have to be funded individually and will never be covered by health insurance, in any countr
Re: Demographics is fate (Score:2)
merit-based dystopia (Score:2)
Oh wait, they made a whole fucking movie about EXACTLY THAT: 'In Time' https://www.youtube.com/watch?... [youtube.com]
furthermore, it is a comment on capitalism where 'time is money'
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Fascinating. You seem to be completely disconnected from reality. At this time, there is not even any indication that significant life extension in humans is even possible.
Does it now? (Score:5, Funny)
What's the drug? (Score:2)
Boosterspice (Score:2)
If they're developing a real-world version of that: sign me up. Take decades off my aging process. Restore me back to my 30's or even my 40's.
But if all they're doing is making you be an old geezer for more years before you drop dead: forget about it, not interested.
Rats live upto 3 years (Score:2, Insightful)
25% of 3 years = 3/4 of a year, or about 9 months.
Reword headline to "Study exhances Rat life expectancy by 9 months"
Result = highly improved accuracy and sharp drop in idiots reading worthless articles
Humans life expectancy is over 80 years. We already know how to live longer than rats do. Our problems are not the same as rats, we have issues with long term chemical buildups, long term effects of radiation, etc. etc. Rats do not have those issues, they never live long enough to get 10 years, let alone
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While all this is true, given that it manages to improve the health of even just 36 months old animals, if it has the same effect on humans, it might simply mean a healthier 60s, maybe 70s. That's not bad at all - not everyone dies of PFAS/plastic build-up, or similar. So, assuming the result can be replicated in humans, it is a positive news.
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So the drug will give us 9 months longer to live!
People would pay that... and for many years since they don't know when they'd die. The irony would be if they died sooner because it does more harm after 12 months of taking it!
It's really simple to assume it will extend humans by 25%. Now if the drug could reverse dementia... keep it away from Trump, I'm enjoying watching his decline; I'm seeing how long it takes before his supporters catch on.
don't get it (Score:2)
Why exactly do we need mice to live longer?
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To rant about stupid IT fads and kick hipsters off our lawns. It's a tough job, but somebody's got to do it.
91 Year Old Stil Teaches Skiing (Score:4, Interesting)
Squeaky Fromme? (Score:1)
I swallowed some while nobody was looking, and let me tell you, my new whiskers and tail look younger than ever!