Scientists Solve the Mystery of How Jellyfish Can Regenerate a Tentacle In Days (technologynetworks.com) 17
An anonymous reader quotes a report from Technology Networks: At about the size of a pinkie nail, the jellyfish species Cladonema can regenerate an amputated tentacle in two to three days -- but how? Regenerating functional tissue across species, including salamanders and insects, relies on the ability to form a blastema, a clump of undifferentiated cells that can repair damage and grow into the missing appendage. Jellyfish, along with other cnidarians such as corals and sea anemones, exhibit high regeneration abilities, but how they form the critical blastema has remained a mystery until now.
A research team based in Japan has revealed that stem-like proliferative cells -- which are actively growing and dividing but not yet differentiating into specific cell types -- appear at the site of injury and help form the blastema. "Importantly, these stem-like proliferative cells in blastema are different from the resident stem cells localized in the tentacle," said corresponding author Yuichiro Nakajima, lecturer in the Graduate School of Pharmaceutical Sciences at the University of Tokyo. "Repair-specific proliferative cells mainly contribute to the epithelium -- the thin outer layer -- of the newly formed tentacle."
The resident stem cells that exist in and near the tentacle are responsible for generating all cellular lineages during homeostasis and regeneration, meaning they maintain and repair whatever cells are needed during the jellyfish's lifetime, according to Nakajima. Repair-specific proliferative cells only appear at the time of injury. "Together, resident stem cells and repair-specific proliferative cells allow rapid regeneration of the functional tentacle within a few days," Nakajima said, noting that jellyfish use their tentacles to hunt and feed. [...] The cellular origins of the repair-specific proliferative cells observed in the blastema remain unclear, though, and the researchers say the currently available tools to investigate the origins are too limited to elucidate the source of those cells or to identify other, different stem-like cells. "It would be essential to introduce genetic tools that allow the tracing of specific cell lineages and the manipulation in Cladonema," Nakajima said. "Ultimately, understanding blastema formation mechanisms in regenerative animals, including jellyfish, may help us identify cellular and molecular components that improve our own regenerative abilities."
The findings were published in the journal PLOS Biology.
A research team based in Japan has revealed that stem-like proliferative cells -- which are actively growing and dividing but not yet differentiating into specific cell types -- appear at the site of injury and help form the blastema. "Importantly, these stem-like proliferative cells in blastema are different from the resident stem cells localized in the tentacle," said corresponding author Yuichiro Nakajima, lecturer in the Graduate School of Pharmaceutical Sciences at the University of Tokyo. "Repair-specific proliferative cells mainly contribute to the epithelium -- the thin outer layer -- of the newly formed tentacle."
The resident stem cells that exist in and near the tentacle are responsible for generating all cellular lineages during homeostasis and regeneration, meaning they maintain and repair whatever cells are needed during the jellyfish's lifetime, according to Nakajima. Repair-specific proliferative cells only appear at the time of injury. "Together, resident stem cells and repair-specific proliferative cells allow rapid regeneration of the functional tentacle within a few days," Nakajima said, noting that jellyfish use their tentacles to hunt and feed. [...] The cellular origins of the repair-specific proliferative cells observed in the blastema remain unclear, though, and the researchers say the currently available tools to investigate the origins are too limited to elucidate the source of those cells or to identify other, different stem-like cells. "It would be essential to introduce genetic tools that allow the tracing of specific cell lineages and the manipulation in Cladonema," Nakajima said. "Ultimately, understanding blastema formation mechanisms in regenerative animals, including jellyfish, may help us identify cellular and molecular components that improve our own regenerative abilities."
The findings were published in the journal PLOS Biology.
Re: (Score:2)
You made a lame joke, but I imagined the time when they start regenerating politicians and I can only shudder in terror.
Re: PROLIFE-rative cells! (Score:2)
Re: (Score:2)
It is not incredible. It is just normal evolution.
Re: (Score:1)
some actually do have that capability, a funny evolution's whim because their high breeding rate is high enough.
however, the acummulation of incompetence does favor the emergence of ever more radical specimen, which of just makes matters worse and you really don't want to see what is at the end of that cycle, when we suddenly that we don't need any more politicians. that's really scary.
Re: (Score:2)
It is like a game of life, but with graft in the squares.
That's Nothing (Score:3)
I've seen a Scotsman first regenerate a severed hand, and then a few years later bi-generate by sprouting a whole Rwandan!
Story is the real deal. (Score:3)
Re: (Score:2)
I just pray it's not the potty tentacle!
Re: (Score:2)
But they don't go into anything, so still a can short of a sixpack.
So, a cure for baldness? (Score:1)
Nobels, baby, lotsa Nobels!
Oh tentacle!! (Score:1)
What could possible go wrong (Score:1)
Great, after feeding jellyfish regeneration capabilities into humans we just need to apply gamma radiation
Academically interesting. But ... (Score:2)
But on the same thinking, there are considerably better wound-repair mechanisms in human infants then in human