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Science

Scientists Solve the Mystery of How Jellyfish Can Regenerate a Tentacle In Days (technologynetworks.com) 17

An anonymous reader quotes a report from Technology Networks: At about the size of a pinkie nail, the jellyfish species Cladonema can regenerate an amputated tentacle in two to three days -- but how? Regenerating functional tissue across species, including salamanders and insects, relies on the ability to form a blastema, a clump of undifferentiated cells that can repair damage and grow into the missing appendage. Jellyfish, along with other cnidarians such as corals and sea anemones, exhibit high regeneration abilities, but how they form the critical blastema has remained a mystery until now.

A research team based in Japan has revealed that stem-like proliferative cells -- which are actively growing and dividing but not yet differentiating into specific cell types -- appear at the site of injury and help form the blastema. "Importantly, these stem-like proliferative cells in blastema are different from the resident stem cells localized in the tentacle," said corresponding author Yuichiro Nakajima, lecturer in the Graduate School of Pharmaceutical Sciences at the University of Tokyo. "Repair-specific proliferative cells mainly contribute to the epithelium -- the thin outer layer -- of the newly formed tentacle."

The resident stem cells that exist in and near the tentacle are responsible for generating all cellular lineages during homeostasis and regeneration, meaning they maintain and repair whatever cells are needed during the jellyfish's lifetime, according to Nakajima. Repair-specific proliferative cells only appear at the time of injury. "Together, resident stem cells and repair-specific proliferative cells allow rapid regeneration of the functional tentacle within a few days," Nakajima said, noting that jellyfish use their tentacles to hunt and feed. [...] The cellular origins of the repair-specific proliferative cells observed in the blastema remain unclear, though, and the researchers say the currently available tools to investigate the origins are too limited to elucidate the source of those cells or to identify other, different stem-like cells.
"It would be essential to introduce genetic tools that allow the tracing of specific cell lineages and the manipulation in Cladonema," Nakajima said. "Ultimately, understanding blastema formation mechanisms in regenerative animals, including jellyfish, may help us identify cellular and molecular components that improve our own regenerative abilities."

The findings were published in the journal PLOS Biology.
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Scientists Solve the Mystery of How Jellyfish Can Regenerate a Tentacle In Days

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  • by cstacy ( 534252 ) on Thursday January 04, 2024 @12:57AM (#64129875)

    I've seen a Scotsman first regenerate a severed hand, and then a few years later bi-generate by sprouting a whole Rwandan!

  • by Valgrus Thunderaxe ( 8769977 ) on Thursday January 04, 2024 @01:13AM (#64129905)
    Japan and tentacles in the same sentence.
  • Nobels, baby, lotsa Nobels!

  • Oh Tentacle... The Internets has ruined me.
  • Great, after feeding jellyfish regeneration capabilities into humans we just need to apply gamma radiation

  • If you're trying to get towards a technique that could help with "wound repair" (much more approachable a target than re-growing an entire leg), you'd probably be better starting with amphibians (some of which can regenerate a whole amputated limb, and they have that whole metamorphosis thing going on too). As vertebrates, their biochemistry is much closer to ours than a coelenterate ("jellyfish").

    But on the same thinking, there are considerably better wound-repair mechanisms in human infants then in human

Stellar rays prove fibbing never pays. Embezzlement is another matter.

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