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Medicine Worms Science

Woman's Mystery Illness Turns Out To Be 3-Inch Snake Parasite In Her Brain 103

An anonymous reader quotes a report from Ars Technica: A neurosurgeon in Australia pulled a wriggling 3-inch roundworm from the brain of a 64-year-old woman last year -- which was quite the surprise to the woman's team of doctors and infectious disease experts, who had spent over a year trying to identify the cause of her recurring and varied symptoms. A close study of the extracted worm made clear why the diagnosis was so hard to pin down: the roundworm was one known to infect snakes -- specifically carpet pythons endemic to the area where the woman lived -- as well as the pythons' mammalian prey. The woman is thought to be the first reported human to ever have an infection with this snake-adapted worm, and it is the first time the worm has been found burrowing through a mammalian brain. [...]

Subsequent examination determined the roundworm was Ophidascaris robertsi based on its red color and morphological features. Genetic testing confirmed the identification. The woman went on ivermectin again and another anti-parasitic drug, albendazole. Months later, her lung and liver lesions improved, and her neuropsychiatric symptoms persisted but were improved. The doctors believe the woman became infected after foraging for warrigal greens (aka New Zealand spinach) around a lake near her home that was inhabited by carpet pythons. Usually, O. robertsi adults inhabit the snakes' esophagus and stomach and release their eggs in the snakes' feces. From there, the eggs are picked up by small mammals that the snakes feed upon. The larvae develop and establish in the small mammals, growing quite long despite the small size of the animals, and the worm's life cycle is complete when the snake eats the infected prey.

Doctors hypothesize the woman picked up the eggs meant for small mammals as she foraged, ingesting them either by not fully washing or cooking the greens or by not properly washing her hands or kitchen equipment. In retrospect, the progression of her symptoms suggests an initial foodborne infection, followed by worm larva migrating from her gastrointestinal tract to multiple organs. The prednisolone, an immunosuppressive drug, may have inadvertently helped the worm migrate and get into the central nervous system. Kennedy, a co-author of the report on the woman's case, stressed the importance of washing any foods foraged or taken from a garden. She also emphasized proper kitchen safety and hand washing.
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Woman's Mystery Illness Turns Out To Be 3-Inch Snake Parasite In Her Brain

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  • by crunchy_one ( 1047426 ) on Tuesday August 29, 2023 @10:36PM (#63807674)
    It seems like the parasite found a way past the blood-brain barrier to evade the medications the patient was given. Impressive.
    • by ShanghaiBill ( 739463 ) on Tuesday August 29, 2023 @11:50PM (#63807766)

      She was given Ivermectin and Albendazole after the worm was removed, just in case there were more worms. Moving into her brain didn't help the worm evade them.

      She was given Prednisolone while the worm was in her, suppressing her immune system and likely helping the worm. Apparently, the doctors thought she might have an auto-immune disease and never suspected a parasite.

      • Re: (Score:2, Funny)

        by KiloByte ( 825081 )

        She was given Ivermectin

        Shouldn't we vaccinate her instead? :p

        • Parasite vaccine (Score:5, Informative)

          by DrYak ( 748999 ) on Wednesday August 30, 2023 @02:04AM (#63807870) Homepage

          Shouldn't we vaccinate her instead? :p

          Jokes aside:
          - Yes, it's possible to develop vaccines against parasites.
          - Currently there isn't any anti-parasite vaccine in regular use.
          - A well known example of anti-parasite vaccine being researched is against malaria(*).

          (*) As this disease is caused by a signle-cell eukaryote (like us) parasite, instead of a bacteria or a virus, there are a lot less possibility to target the small difference in how their biochemistry work (e.g. you can't target a RNA-based viral polymerase or bacterial cell wall with some inhibitor).

          • Plasmodium is a parasite...

            • Plasmodium is, indeed, a parasite.

              It is also a single-celled eukaryote.

              " Parasite" is a description of one (or more) stages of the lifestyle of an organism, not a description of it's biochemistry.

              If two organisms have similar biochemistry, a drug (any chemical) that interacts with the biochemistry of one, has a fairly good chance of interacting with the biochemistry of another. That's why, for example, chemotherapy against cancer is very often a race between killing the cancer and killing the patient : the

          • - Currently there isn't any anti-parasite vaccine in regular use.

            That is false, but actually only because of development that are very recent. Mosquirix, an anti-malaria vaccine was approved for use in April this year, and is actively being given to children in high-risk areas with over 1.5million vaccinations already given out and more and more coming every day. Its efficacy is somewhat low, but it is still technically an anti-parasite vaccine currently in regular use.

            • only because of development that are very recent. Mosquirix, an anti-malaria vaccine was approved for use in April this year, and is actively being given to children in high-risk areas with over 1.5million vaccinations already

              Oh, thanks for the update!
              I missed that recent development, and was wrongly thinking that malaria vaccination was still at the clinical research stage.
              Cool that it went to production! Hopefully it will be able to make some impact despite the relatively low efficacy.

        • Shouldn't we vaccinate her instead? :p

          Roundworm conspiracy theorists are insisting that only the Soros cabal wants you to take ivermectin for parasites. They can ship you messenger RNA treatments from Venezuela instead.

      • Re: (Score:2, Informative)

        by Anonymous Coward

        She was given Ivermectin and Albendazole after the worm was removed, just in case there were more worms. Moving into her brain didn't help the worm evade them.

        She was given Prednisolone while the worm was in her, suppressing her immune system and likely helping the worm. Apparently, the doctors thought she might have an auto-immune disease and never suspected a parasite.

        The article says her lungs and liver improved after initial treatment with ivermectin, before surgical removal of the worm, but the parasite survived.

        Ivermectin does not cross the blood-brain barrier [wikipedia.org] in adult mammals [wikipedia.org] at normal therapeutic doses.

  • by TwistedGreen ( 80055 ) on Tuesday August 29, 2023 @10:38PM (#63807676)

    Literal mindworms. Cool!

  • by bugs2squash ( 1132591 ) on Tuesday August 29, 2023 @10:43PM (#63807686)
    They pulled one out - I wonder how many were left inside her.
    • Re: (Score:2, Funny)

      by echo123 ( 1266692 )

      Don't ever laugh as a hearse goes by
      For you may be the next to die
      They wrap you up in a big white sheet
      From your head down to your feet
      They put you in a big black box
      And cover you up with dirt and rocks
      And all goes well for about a week
      And then your coffin begins to leak
      And the worms crawl in, the worms crawl out
      The worms play pinochle on your snout
      They eat your eyes, they eat your nose
      They eat the jelly between your toes
      A big green worm with rolling eyes
      Crawls in your stomach and out your eyes
      Your stomach

    • Re: (Score:3, Funny)

      They pulled one out - I wonder how many were left inside her.

      That's why they gave her Ivermectin and Albendazole. They are anti-parasite medications for roundworms. They were prescribed just in case there were more worms.

      Ivermectin also cures Covid, but only in Republicans.

      • by sodul ( 833177 )

        Considering her liver and lung lesions started to heal after taking the medication it is safe to assume that they made their way to these organs. My guess is that the patient has permanent brain damage but things stopped getting worse.

        • Re:one (Score:5, Funny)

          by backslashdot ( 95548 ) on Wednesday August 30, 2023 @12:43AM (#63807812)

          My guess is that the patient has permanent brain damage

          In that case we'll find out soon enough when she starts posting on slashdot as Anonymous Coward.

        • My guess is that the patient has permanent brain damage but things stopped getting worse.

          Sounds like she might be the next Presidential candidate. I know she's in Australia but is she an American citizen?

          LK

  • Granted in this case the patient eat the worm, but they had a compromised immune system and that plant grows close to the ground where it is more likely to pick droppings.

    In most cases it generally safe to eat wild food without a sterile environment to wash them in. I do eat berries in the woods when available, they are usually much tastier than store bought. Of course I do not pick the ones I'm not familiar with and I avoid the ones close to the ground where wildlife could pee on it.

    • by Tony Isaac ( 1301187 ) on Tuesday August 29, 2023 @11:12PM (#63807716) Homepage

      Physicians also used to think that washing their hands between treating patients, was overkill. Sure, 95% of the time, it might not result in a brain parasite. But that doesn't mean it's overkill to was your hands (or foraged food) every time, to avoid that 5% chance of a serious illness or other health issue.

    • You know it's hard understanding your point about not washing wild food with a mouth full of caveats...

    • What is the harm you're trying to avoid by eating filthy, shit covered wild berries without at least rinsing them first?

  • Parasite (Score:5, Funny)

    by rlwinm ( 6158720 ) on Tuesday August 29, 2023 @10:55PM (#63807692)
    Too bad it didn't give her glowing eyes and the knowledge to build a pyramid shaped space ship.
  • That scene from The Wrath of Khan suddenly makes a lot more sense

  • by Gavino ( 560149 ) on Tuesday August 29, 2023 @11:02PM (#63807704)
    ..they are taking their life into their own hands whenever they venture outside.
    • by q_e_t ( 5104099 )
      Or visit the bathroom as a spider might bite them on the bum.
  • Members of Congress deny having eaten any unwashed vegetables or snake eggs. Said one MC who was wearing a sweatsuit: "A-h-h-ha-ah gn-gn-bing-proo-meeegie". A Congressional Page stepped up and interpreted: "He says we have to ban Legos because of climate change."
  • goa'uld

  • KHAAAAAAAAAAAAN!

  • Hell nah on the brain parasite, phoning a friend.

  • We may want to xray anti vaxers, flat earthers, Trump, Poetin, ...
  • Hoe come Al didn't detect this? I thought Al was so smart.

  • by sid crimson ( 46823 ) on Wednesday August 30, 2023 @07:02AM (#63808126)

    He would have taken around 60 minutes, less commercial breaks.

    • He would have had at least two false diagnoses first, one of which would likely lead to a traumatic test or treatment, and there's a good chance he would reveal your spouse was cheating on you.

      • He would have had at least two false diagnoses first, one of which would likely lead to a traumatic test or treatment, and there's a good chance he would reveal your spouse was cheating on you.

        Fair point - he might have had fewer false diagnoses than the Drs in this real life case!

  • I thought I had a brain worm [urbandictionary.com] once. It turned out to be a Baby Shark.

  • I am so glad I read this in the morning instead of before bed.

  • "O. robertsi adults inhabit the snakes' esophagus and stomach and release their eggs in the snakes' feces. From there, the eggs are picked up by small mammals that the snakes feed upon. The larvae develop and establish in the small mammals, growing quite long despite the small size of the animals, and the worm's life cycle is complete when the snake eats the infected prey."

    Soo-- small mammals eat snake shit, that is composed of undigested material of their own ancestors-in order to pass the eggs along to t

  • I'm surprised - nay, disappointed - that the Slashdoterati haven't remembered trichinosis [wikipedia.org] yet.

    FTFwikilink ;

    a parasitic disease caused by roundworms of the Trichinella type. [...]
    mainly spread when undercooked meat containing Trichinella cysts is eaten [...]
    Worldwide, about 10,000 infections occur a year. At least 55 countries including the United States, China, Argentina, and Russia have had recently documented cases. [...]
    Rates of trichinosis in the United States have decreased from about 400 cases per

  • I was recently admitted for what appeared to be a major heart attack.

    I was in intense pain which duplicated the pattern of a heart attack.

    But it was not a heart attack (blood tests showed no heart damage). The doctors gave me a cat scan, morphine (useless), and finally said, "We are sorry you are hurting but we can't find anything life threatening except the high blood pressure from the pain.)

    The actual problem?

    Dislocated left rib over the heart. It was out about 1/8" and every muscle remotely attached t

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