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Science

The Sleep Debt Collector Is Here (nytimes.com) 41

Recent studies in humans and mice have shown that late nights and early mornings may cause long lasting damage to your brain. From a report: The sleep debt collectors are coming. They want you to know that there is no such thing as forgiveness, only a shifting expectation of how and when you're going to pay them back. You think of them as you lie in bed at night. How much will they ask for? Are you solvent? You fall asleep, then wake up in a cold sweat an hour later. You fall asleep, then wake up, drifting in and out of consciousness until morning. As most every human has discovered, a couple nights of bad sleep is often followed by grogginess, difficulty concentrating, irritability, mood swings and sleepiness.

For years, it was thought that these effects, accompanied by cognitive impairments like lousy performances on short-term memory tests, could be primarily attributed to a chemical called adenosine, a neurotransmitter that inhibits electrical impulses in the brain. Spikes of adenosine had been consistently observed in sleep-deprived rats and humans. Adenosine levels can be quickly righted after a few nights of good sleep, however. This gave rise to a scientific consensus that sleep debt could be forgiven with a couple of quality snoozes -- as reflected in casual statements like "I'll catch up on sleep" or "I'll be more awake tomorrow."

But a review article published recently in the journal Trends in Neurosciences contends that the folk concept of sleep as something that can be saved up and paid off is bunk. The review, which canvassed the last couple of decades of research on long term neural effects of sleep deprivation in both animals and humans, points to mounting evidence that getting too little sleep most likely leads to long-lasting brain damage and increased risk of neurodegenerative disorders like Alzheimer's disease. "This is really, really important in setting the stage for what needs to be done in sleep health and sleep science," said Mary Ellen Wells, a sleep scientist at the University of North Carolina, who did not contribute to the review.

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The Sleep Debt Collector Is Here

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  • by sleep-doc ( 905583 ) on Friday June 24, 2022 @08:09PM (#62649066)
    In addition to the quantity of sleep, quality and timing make big differences. Individuals with sleep apnea, for example, with poor sleep quality and fragmented sleep can spend 8 hours "sleeping" and still be nonrestored, as well as suffer a growing catalog of long term consequences in the neurologic, cardiovascular and metabolic domains. Trying to live, or for that matter sleep, out of phase with your circadian rhythm - as for example sleeping 'til noon on weekends and arising (or trying to) at 7am on weekdays - leads to its own significant dysfunction.
    • by Baconsmoke ( 6186954 ) on Friday June 24, 2022 @08:20PM (#62649088)
      Yeah, my sleep apnea keeps me from ever getting into real sleep. I dream the entire night through. All of it. No breaks. My dreams are so boring it would put dead people to sleep. I will literally dream about sitting down in various chairs and even in my dream they last forever. I wake up in the morning only slightly less exhausted then when I went to bed. I've tried the stupid CPAP over and over and over again. But my dumb asleep brain just rips it off and throws the mask on the floor without my conscious mind knowing about it. Guess I'll just fucking die early because I can't stop myself from being stupid.
      • There are also dental devices that can hold the airway open, if you can't use CPAP for some reason.

        I also have sleep apnea. Funny thing is - I didn't realize just how messed up my sleep was until I started sleeping with a CPAP (well technically a BiPAP) machine and getting decent sleep. Now I do my best to use it all the time - even if I'm just napping during the middle of a Saturday.

      • by CaptQuark ( 2706165 ) on Saturday June 25, 2022 @01:47AM (#62649414)

        I've tried the stupid CPAP over and over and over again. But my dumb asleep brain just rips it off and throws the mask on the floor without my conscious mind knowing about it.

        One thing I found was the TYPE of mask you use is very important. I've tried several different masks and found the simple nasal pillow with the swivel on the front works best for me. People who primarily sleep on their sides might have a different preference than those the sleep primarily on their backs. Some people have a problem with the high pressure air escaping out their mouths as they sleep so a full-face mask might be better for them. I tried a nasal cup once but because I have a mustache, it leaked too much and I didn't sleep well with it. Another model had the hose swivel on the side and that prevented me from sleeping on that side, so I asked for a new mask model. I eventually found the type that worked best for my sleep habits.

        Also, the settings on the CPAP can make a huge difference on what your body perceives as acceptable pressure. I have my CPAP set to ramp up to operating pressure quickly so I don't feel like I'm being smothered as I fall asleep. Other people complain that when the CPAP ramps up to stop snoring or breathing interruptions, it doesn't ramp back down again often enough and leaves the person feeling like they are trying to sleep in a wind tunnel.

        I would suggest you make an appointment with your sleep specialist to discuss your mask type and perhaps your machine settings. I understand not everyone can sleep with a CPAP, but at least give the equipment the same customization effort you would with give something like a new scuba regulator and explore all the settings before you toss it.

        https://www.cpap.com/blog/diff... [cpap.com]

      • Your getting further than me, because I've yet to be able to sleep with the mask on. My father is suggesting to try the nose cuishion, as he said he couldnt sleep with the mask, but the nose one worked a treat.

        Cos if that doesnt work, I'm fucked. Whee.

      • FWIW, my sleep apnea stopped when I got my nose reamed out. I wish I'd had it done a lot sooner.

        • Not sure if you'll see this reply. What is the name of the procedure you had done? It it Turbinoplasty? Not sure if it's the same, but I saw another website talk about Nasal Airway Remodeling? I'm seriously interested.
          • CRAP. I wrote a long thing and then wanted to look at the options (below) and BANG my reply was gone!

            I got an email announcement about your response to my post. Nice!

            Can't remember the exact name, but the turbinates were involved. I was absolutely unable to breathe through my nose and put off having it fixed for decades because of horror stories about the packing removal feeling like pulling your brain out your nostril Not true. No packing now, just an easy-to-remove-by-doc plastic shield. I wish I'd h

  • by geekymachoman ( 1261484 ) on Friday June 24, 2022 @08:35PM (#62649124)

    The machine provides caffeine for you, for free, so you can wake up earlier than you should and still function. Debt?

    Don't worry about debt... debt is good!

  • That's going to make this worse. Though in some reality I'm really well rested, so there's hope. lol :)

  • As a Buddhist (Score:4, Interesting)

    by plate_o_shrimp ( 948271 ) on Friday June 24, 2022 @09:29PM (#62649170)
    ...and long-term meditator who has sat yaza (all-night sits) many times, I'm absolutely willing to accept that sleep deprivation can cause brain changes. Based on first-hand experience I'm not willing, however, to accept that those changes are always necessarily brain damage. I think there's a lot of subtlety and nuance that's being glossed over here...
    • I think there's a lot of subtlety and nuance that's being glossed over here...

      Noooo, really? Mind is the most amazing thing in the universe still comprehensible by humans, and really not even by them. Its next step is to be rid of the brain so it can wander through space, immaterial, like in 1950s SF. Most of what Science and Religion excoriate is that which is simply the Future winking at us over the fence. Meanwhile, Politicians, Generals, and Bankers are ossified in the status quo.

    • Some close-minded, Dunning-Kruger magical thinking you got there with your unscientific conjecture.

      And, it's already been proven.

      https://www.jneurosci.org/cont... [jneurosci.org]

    • Would a damaged brain recognize itself as damaged?

  • The longest I've ever stayed up without sleep was 5.5 days. I guess I'm screwed now but at least I've beat the puppies mentioned in the article.

  • Burnout (Score:5, Interesting)

    by VeryFluffyBunny ( 5037285 ) on Saturday June 25, 2022 @03:04AM (#62649494)
    TFS describes the symptoms of we colloquially call burnout, not an officially recognised condition but a variety of effects of working long hours &/or not sleeping enough. If you've ever had to manage people in highly demanding stressful jobs, you see it all the time. It affects their relationships with colleagues (& more than likely with friends & family) & the quality of their work. It's counter-productive to keep people working when they're in that state - you're paying them to be an unproductive problem for everyone. What the sufferers need is to work less or take a holiday. Now try explaining that to senior management & there you see the root of the problem.
  • Too late (Score:5, Insightful)

    by Anonymous Crowded ( 6202674 ) on Saturday June 25, 2022 @06:48AM (#62649698)
    For most of us, the damage is done. Give us the cost in years, fund our retirement that many years early. They sure as hell aren't going to start allowing us to be healthy.
  • by Kevin108 ( 760520 ) on Saturday June 25, 2022 @10:05AM (#62649892) Homepage

    You don't get anything done. You don't learn anything new. You don't do anything fun. I might get about 5-6 hours a night. I could sleep more, and when not on a work schedule I usually do. But during the week, there's just not enough time in the day for me to work, get everything done I need or want to, and adequately unwind enough to go to sleep. Sleep is a waste of time. I hate it.

    • You don't do anything fun.

      I've met interesting women there but they were mostly after one thing and didn't speak. Interestingly I can't do math or read text, I can tell its words or math but it won't resolve to anything recognizable when awake.

      Yeah, missing sleep comes with compound interest due til its paid off, should be obvious to anyone.

      • I seldom remember my dreams. The last one of any consequence I recall was earlier this year, I dreamed about spending some time with my Dad. He passed away 4 years ago. In the dream, we were just doing normal stuff like he and I used to do together, but he was about 10 years younger than when I saw him last, still strong and healthy. It was really nice to see him again.

      • I can read in dreams, but anything more than a short sentence or two devolves into nonsense. Sometimes I can do basic math and even code fragments in dreams but nothing complex.

  • A popsicle stick Tower of Babel to the moon. Really, that's what so many countless self sacrifices and people being chewed up up by the ever roving "machine" are for.

      To hell with society, to hell with people's constantly butthurt fee fees. Flying solo, ripping off the yoke put on you by other people, and making you and your family content is what really matters. Everything else is just noise.

  • I've got borderline apnea and found the CPAP was more trouble than it was worth (just made me sleep worse, even after I found the best mask for me which was the nasal pillow discussed earlier). But, a good sleep tracking app and monitor did wonders. I've used a Pebble watch that could monitor heartbeat and movement for a long time (it finally died and now I've got a Ticwatch that also adds oxygen monitoring), and the Sleep for Android app - the key feature there is the ability to set smart alarms that wat

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