Scientists Build Synthetic Fish That Swim Using Lab-Grown Human Heart Cells (npr.org) 15
An anonymous reader quotes a report from NPR: Scientists have built a school of robotic fish powered by human heart cells. The fish, which swim on their own, show how lab-grown heart tissue can be designed to maintain a rhythmic beat indefinitely, a team reports in the journal Science. "It's a training exercise," says Kit Parker, a professor of bioengineering and applied physics at Harvard. "Ultimately, I want to build a heart for a sick kid."
The tiny biohybrids, based on zebrafish, are built from paper, plastic, gelatin and two strips of living heart muscle cells. One strip runs along the left side of the robot's body, the other along the right. When the muscle cells on one side contract, the tail moves in that direction, propelling the fish through the water. The movement also causes the strip of muscle cells on the opposite side to stretch. This stretching, in turn, produces a signal that causes the cells to contract, which perpetuates the swimming motion. "Once that cycle starts, these things just start motoring," Parker says.
The fish are equipped with a special cluster of cells that initiate the cycle of stretching and contracting, Parker says. [...] The fish kept swimming for more than three months, sustained by nutrients added to the fluid around them. Showing that it's possible to produce human heart tissue that beats on its own is important because the body can't replace heart cells lost to disease or inflammation. "Once you're born, about two days after you leave the womb, the number of cardiac muscle cells you have then is all you're going to have for the rest of your life," Parker says. [...] Heart cells stay healthy by constantly rebuilding themselves, a process that takes about 20 days, he says. Because the fish swam for more than 100 days, he says, "each cell has rebuilt itself in there about five times." The muscle cells also became stronger with exercise the way cells in a human heart do. This suggests the cells could eventually be used to repair a failing heart.
The tiny biohybrids, based on zebrafish, are built from paper, plastic, gelatin and two strips of living heart muscle cells. One strip runs along the left side of the robot's body, the other along the right. When the muscle cells on one side contract, the tail moves in that direction, propelling the fish through the water. The movement also causes the strip of muscle cells on the opposite side to stretch. This stretching, in turn, produces a signal that causes the cells to contract, which perpetuates the swimming motion. "Once that cycle starts, these things just start motoring," Parker says.
The fish are equipped with a special cluster of cells that initiate the cycle of stretching and contracting, Parker says. [...] The fish kept swimming for more than three months, sustained by nutrients added to the fluid around them. Showing that it's possible to produce human heart tissue that beats on its own is important because the body can't replace heart cells lost to disease or inflammation. "Once you're born, about two days after you leave the womb, the number of cardiac muscle cells you have then is all you're going to have for the rest of your life," Parker says. [...] Heart cells stay healthy by constantly rebuilding themselves, a process that takes about 20 days, he says. Because the fish swam for more than 100 days, he says, "each cell has rebuilt itself in there about five times." The muscle cells also became stronger with exercise the way cells in a human heart do. This suggests the cells could eventually be used to repair a failing heart.
Re: (Score:2)
I cringe everytime I read of human tissue transplanted into another animal.
In this case, the "other animal" is a robot.
No disease will be transmitted.
Re: (Score:3, Funny)
Re: (Score:2)
But when you put Hitler's brain in a robot fish powered by human heart cells, suddenly you've gone too far.
It's not Hitler.
His name is "Klaus".
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But when you put Hitler's brain in a robot fish powered by human heart cells, suddenly you've gone too far.
Yeah, 'cause now you've got a robot fish that will give the sharks a taste for human heart and brains. Duh.
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...says the arrogant Scott Adams type midwit who still has a G+ link in his profile (it was always lame)
This is not how you make an incubator for zoonoses you absolute clown
Playing God (Score:1)
I'm not enormously religious, and perhaps I'm just getting old - but these sorts of experiments don't sit well with me at all. God knows what's coming next...
Re: (Score:2)
You don't want a way to repair human hearts? I mean.. this is the road we need to go down... try things out in non-humans until it all works well enough for human trials.
Or do you want to get the pre-alpha release to try out yourself?
Re:Playing God (Score:5, Insightful)
You know why? Because it shows that we are just machines, albeit complex ones. No soul, no dis-incarnated mind, and certainly no eternal bliss after we die or other bullshit like that. Nothing special. We're just a bunch of mechanical parts that jiggle in a complex movement amidst other bunch of mechanical parts that jiggle, and we don't like that.
fish hearts (Score:2)
I took my fish heart
Out to see a movie
Fish hearts, Fish hearts
Eat them up YUM!
number of cardiac muscle cells (Score:3)
How can it be constant from age two days? Adult hearts are obviously larger in size than infant hearts. Doesn't that mean they have more cells?
Re: (Score:2)
How can it be constant from age two days? Adult hearts are obviously larger in size than infant hearts. Doesn't that mean they have more cells?
The cells get bigger.
My Heart Will Go On (Score:2)
And on and on..
in a robotic fish.
these people should not set boundaries for us (Score:2)
And they go and do this?!
Please stop telling lawmakers we can and cannot do unless you're doing it in your personal opinion as such.
Long before a single kid is saved... (Score:1)