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Medicine

Pfizer CEO Says Third Covid Vaccine Dose Likely Needed Within 12 Months (cnbc.com) 408

Pfizer CEO Albert Bourla said people will "likely" need a booster dose of a Covid-19 vaccine within 12 months of getting fully vaccinated. His comments were made public Thursday but were taped April 1. From a report: Bourla said it's possible people will need to get vaccinated against the coronavirus annually. "A likely scenario is that there will be likely a need for a third dose, somewhere between six and 12 months and then from there, there will be an annual revaccination, but all of that needs to be confirmed. And again, the variants will play a key role," he told CNBC's Bertha Coombs during an event with CVS Health. "It is extremely important to suppress the pool of people that can be susceptible to the virus," Bourla said. The comment comes after Johnson & Johnson CEO Alex Gorsky told CNBC in February that people may need to get vaccinated against Covid-19 annually, just like seasonal flu shots. Researchers still don't know how long protection against the virus lasts once someone has been fully vaccinated.
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Pfizer CEO Says Third Covid Vaccine Dose Likely Needed Within 12 Months

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  • by Rei ( 128717 ) on Friday April 16, 2021 @09:02AM (#61280222) Homepage

    But as someone who lives in Europe, it sure would be nice to be able to get my *first* shots at some point before the sun goes nova.

    • FWIW only about half the people that want one have got their first shot in US (though I know we're hardly the paragon of good health system here).

    • But as someone who lives in Europe, it sure would be nice to be able to get my *first* shots at some point before the sun goes nova.

      Yeah - what's the deal with that? Over here, for all of the reports that would have Americans massively anti-vax, we've organized and dispensed a lot of vaccines.

      In my area, we're opening up eligibility for everyone soon and in some places now, I got mine in February, my wife just got her second shot last week - she's a lot younger than me, and my son who's in his late 20's just got his first.

      So what's the deal?

      • by Rei ( 128717 ) on Friday April 16, 2021 @09:41AM (#61280444) Homepage

        Supply. It's 100% about supply. We get a batch use all within 1-2 days, then sit around on our arses waiting for more :(

        The US has been awash in supply compared to most of the world. Which makes it so frustrating to see vaccine at times going to waste or taking long periods of time to distribute due to rollout incompetence in the US, when we're sitting over here just waiting to get our hands on some.

        Moderna is a US company, and all stages of production are in the US. Pfizer is a US company. BioNTech is a German company, but the first two stages of the vaccine have been produced exclusively in the US, and the third stage predominantly in the US, with only a small plant in Belgium. They're commissioning a new plant for the second and third stages in Germany which should eventually help.

        Europe had planned on AstraZeneca being the biggest part of its supply, but its rollout turned out to be a trainwreck. J&J was also supposed to be a lesser but meaningful portion of the supply.

        • Re: (Score:2, Insightful)

          by nifibig336 ( 7985108 )

          Moderna is a US company, and all stages of production are in the US. Pfizer is a US company. BioNTech is a German company, but the first two stages of the vaccine have been produced exclusively in the US, and the third stage predominantly in the US, with only a small plant in Belgium.

          That is because Americans work too hard. They don't get eight weeks of vacation like you enlightened people. They are all slaves to Big Western Corporations. Well at least you have your Tesla to drive around in, right Rei?

          • by Rei ( 128717 ) on Friday April 16, 2021 @10:02AM (#61280572) Homepage

            So your "American hard work ethic" has exactly what to do with adenovirus vaccines turning out to be problematic in production, efficacy and side effects?

            Well at least you have your Tesla to drive around in, right Rei?

            Yeah, it's nice not having to go to gas stations in a pandemic :)

        • by Rei ( 128717 ) on Friday April 16, 2021 @09:47AM (#61280476) Homepage

          The three stages, FYI, are:

          1) Breeding bacteria to produce DNA plasmids that code for the spike protein, then harvesting those plasmids
          2) Using the plasmids to mass produce mRNA that codes for the spike protein
          3) Combining the mRNA with lipid nanoparticles and other vaccine components, and bottling

          It used to take about 120 days from start to finish. Now it takes about 60 days (half of that is quality assurance). The new plant in Marburg, Germany (which still gets its DNA from the US, but does everything else) was supposedly completed around the end of March.

          Another piece of upcoming supply should hopefully be CureVac. They've never targeted becoming a huge supplier, and they're very late to the game, but with a mRNA vaccine similar to Pfizer and Moderna, it's probably a good one. Phase 3 results should be unveiled soon, followed by (if everything goes right) approval in a week or two. We don't know how much vaccine they've produced thusfar, but their target for 2021 is 300M doses.

        • by reanjr ( 588767 ) on Friday April 16, 2021 @10:00AM (#61280556) Homepage

          Strange. It's almost as if having an expensive for-profit healthcare system leads to better outcomes for people during significant global health events. Or maybe it's as if socialized healthcare suffers from focusing so much on being fair, that it prefers being fair over being healthy.

          I wonder why no one has thought of this before and written countless articles about the different dynamics of different approaches to healthcare...

          • Nah, must be some other reason. Americans are all stupid, lazy and fat remember? They must have stolen the vaccine formulas from someone.
          • by jacks smirking reven ( 909048 ) on Friday April 16, 2021 @10:10AM (#61280616)

            You're partially correct.

            America's healthcare system has lead to a better vaccination rollout but we handled the overall pandemic pretty poorly amongst developed nations and even badly compared to some undeveloped nations.

            Overall though in terms of health many of the countries with universal/socialized health systems tend to have better overall health outcomes in terms of chronic conditions, life expectancy and overall satisfaction with the system. You can absolutely get the best care in the USA if you can afford it

            If anything with all the coverage extensions and the program that is making vaccination free on site for everyone the pandemic has shown many people here a bit of the potential of what a universal system could look like in the US.

          • by AvitarX ( 172628 ) <.gro.derdnuheniwydnarb. .ta. .em.> on Friday April 16, 2021 @10:11AM (#61280620) Journal

            Strange.

            I got my vaccine for free from a state run site staffed by the national guard with doses provided by the federal government.

            The only more socialized experience available in the US is probably going to a state run prison.

            • Re: (Score:3, Informative)

              by wosehi6883 ( 7985292 )
              The doses were invented/produced/shipped and provided by capitalist corporations using taxpayer money and are being administered by people who work in the for-profit healthcare industry.
            • by jwhyche ( 6192 ) on Friday April 16, 2021 @10:38AM (#61280806) Homepage

              I got my vaccine for free from a state run site staffed by the national guard with doses provided by the federal government.

              I got my vaccine free from the state in the park. I was just standing there minding my own business, then someone popped out of the bushes in a gilly suit. Popped my ass from 30 yards away. It was a great shot.

              I heard they are going to use helicopters to vaccinate the local community college next week.

          • by ceoyoyo ( 59147 )

            Let's not get carried away. The US still has a pretty awful COVID morbidity and mortality rate compared to most countries. They are vaccinating pretty quickly, but not as quickly as the UK, Israel, or a couple other countries, and are only doing so because of a massive collective (i.e. socialized) effort.

        • Moderna is also making in Switzerland (and filling vials in Spain).
          The Puurs Pfizer plant in Belgium is not a small plant by any standard. It's one of the biggest COVID-19 vaccine plant worldwide so far. It is supplying the whole world except the USA.

          Anyways the location and nationality of the producer shouldn't matter that much. The UK got a lot of Pfizer vaccines from Belgium. Israel too. Israel didn't produce any vaccine locally, and yet they are pretty much done with vaccinating the 16+ years old.

          Howeve

    • But as someone who lives in Europe, it sure would be nice to be able to get my *first* shots at some point before the sun goes nova.

      Let's not forget that one of the most virulent and common COVID variants in circulation right now is the British one thanks to our favourite pandemic fighting wunderkind Boris Johnson and his genius idea of achieving herd immunity by doing nothing to stop the spread of COVID. The EU messed up the original rollout by overlying on Astra Zeneca but they now have something like 2-3 billion COVID vaccine doses coming down the pipes in the next few months from seven different companies not counting AZ. The Marbur

    • As someone who is stuck in Europe - Don't worry, we will likely all get Covid before there are effective shots available, so then we won't need it anymore.
    • by GuB-42 ( 2483988 )

      Come on, you will get your dose, and so am I (I live in France, which is average for the EU). If all goes well, and I don't see why it wouldn't, probably around September or so, because I am considered low risk.

      Europe is lagging a month or two behind the US, itself about one month behind the UK, but after a year of not being able to do anything, I can wait a couple of months. Selfishly, I would have liked me and my country to be first in line but you don't make billions of doses magically appear overnight.

  • by GameboyRMH ( 1153867 ) <<moc.liamg> <ta> <hmryobemag>> on Friday April 16, 2021 @09:03AM (#61280228) Journal

    COVID19 will probably hang around in animals for a long time, possibly forever, so even if it were eradicated from the human population, it could easily jump back to our species again from wild animals.

    • If only preventing this from happening were as easy as leaving those known carrier species off plates.

      • Yes, if only it were that easy. Unfortunately "known carrier species" are many and are likely to increase over time, and people will can still come into contact with wild animals if they do anything outdoors, and also indirectly through farm animals and pets.

        • by hey! ( 33014 )

          SARS-CoV-2 and closely related viruses like SARS-CoV and MERS-CoV, bind to ACE2 inhibitors, which not only give them access to a wide variety of human tissues, but also many potential mammalian hosts.

          If it is allowed to persist in the human population at a high level, eventually we'll see it jump to new zoonotic reservoirs like domestic animals and livestock.

      • The way this virus first entered the human population isn't known, and may have nothing to do with people "eating bats". It could well be the same story as MERS, which is presumed to have gotten into camels (which then infected people) because their feed was contaminated by bat poop. Sometimes bats like to roost in barns where other animals are kept, and you're not going to bat-proof every barn in every part of the world that has bats.

        If we completely stopped animal farming and meat eating, it would help be

    • by sinij ( 911942 )
      Zoonotic diseases (i.e. originated in wild animals) are rare and unlikely to be very virulent. Virus has to adapt to each new host, so if such outbreaks detected early they can be easily stopped. This is why SARS was successfully eradicated in humans - it wasn't that virulent and did not have significant asymptomatic transmission. COVID19 is unique in this sense is that when we detected it, it was already highly adapted to human hosts (and indoor transmission). This means there was either a lengthy period o
      • We've seen SARS-CoV-2 jump to other species easily since infecting humans, to tigers in zoos and to minks for example. Do you think there's a chance it was a product of gain of function research for infecting those species too? Made to target Siegfried and Roy, or Joe Exotic perhaps?

        It likely has these unusual abilities because it spent a lot of time infecting bats, which have highly advanced immune systems, and now it blows through the relatively simple immune systems of everything else it encounters.

      • Re:He's right (Score:4, Insightful)

        by DamnOregonian ( 963763 ) on Friday April 16, 2021 @10:01AM (#61280566)

        Zoonotic diseases (i.e. originated in wild animals) are rare and unlikely to be very virulent.

        Complete nonsense.

        Have you ever wondered why avian and swine influenza are named as such?

      • by flink ( 18449 )

        So no, if COVID19 were eradicated from the human population it could not easily jump back. However, it is exceedingly unlikely it will ever get fully eradicated.

        Especially not if pharma companies button up vaccine formulas for profit, rather than licensing it free to third world countries so it can be freely distributed to their citizens, like AstraZeneca did with the Oxford vaccine. This was after Oxford was bullied into giving AstraZeneca an exclusive license [fortune.com]. Oxford had previously intended to open source the vaccine, but was coerced into the change by the Gates foundation, a major donor to Oxford. The Gates foundation also just happens to be a major shareholde

  • and the government will need to cover the cost with no changes to the patient no matter what plan they are on.

    • Where do you think the government gets money from? The tooth fairy? Santa Claus?
      They get money from TAXATION!
      You are paying for it anyway.
      • Re: (Score:3, Funny)

        Nah, bruh, they get it via fiat money printing. The Fed accommodates the Treasury by printing a metric shitton of money into existence and giving it to Uncle Sam. Paying taxes is soooo passe' now. You gotta get with the times and learn to destroy the Dollar. We can have everything we want. Freemoney for the lazies and the kids. Freeheath for everyone. Freeschool for everyone (plus full forgiveness of student loans - we'll just print the payments to the banks). Free bullets anytime you wanna protest etc...
        • up to the amount of goods and services our civilization is capable of producing.

          The Government printing money is only a problem when it causes inflation without increasing economic activity. Per worker Productivity since the 50s is up by a factor of 4. That means you're 4 times more productive than your granddad. And your grandma was stay at home, your mom, let alone your wife, almost certainly works.

          This is why when the debt to GDP hit 1 to 1 the country didn't collapse like we were told in the 80s
  • by JoshuaZ ( 1134087 ) on Friday April 16, 2021 @09:11AM (#61280266) Homepage

    This is really only an issue if we can't wipe COVID-19 out. This means it is really important to get as many people as possible vaccinated. That has to include populations which are getting low rates of vaccination now, whether due to lack of easy access or do to actual vaccine hesitancy. In the US, white, rural southerners https://www.npr.org/sections/health-shots/2021/04/15/987412681/its-not-a-never-thing-white-rural-southerners-are-waiting-to-get-the-vaccine [npr.org] , and urban blacks are two of the groups which have the lowest vaccine uptake rates. In the first case, this seems to be largely due to vaccine hesitance, while the second is a combination of access and hesitance https://www.npr.org/sections/coronavirus-live-updates/2021/03/18/978609955/addressing-racial-divides-in-health-care-seen-as-key-to-boosting-black-vaccinati [npr.org]. Outside the US vaccine uptake rates vary a lot to very high (Israel and the UK), to very low (Brazil).

    Unfortunately, the very well publicized pause of the Johnson and Johnson vaccine has likely increased vaccine hesitance in the US https://abc7news.com/pause-on-johnson-and-covid-vaccine-jj-/10513216/ [abc7news.com] https://www.washingtonpost.com/politics/vaccine-pause-hesitancy/2021/04/14/e2728742-9c7a-11eb-9d05-ae06f4529ece_story.html [washingtonpost.com]. Worse, the pause means that some crucial groups are not getting the vaccine one would want them to. For example, a migrant worker may not have an easy ability to schedule for two different vaccine appointments weeks apart. So getting such a person the J&J vaccine helps out. Overall, seems likely that the Johnson and Johnson pause is going to cost lives and make it much more likely that we need to do something like what the article is talking about.

    • by Rei ( 128717 )

      Outside the US, UK, Israel, and a couple other countries, "vaccine uptake rates" are extremely low because we can't get ahold of the friggin' vaccine. Well over 90% of our country polled wants to be vaccinated. We're still only vaccinating the over-70 group, and haven't even started the chronic-conditions groups. There is no global "vaccine hesitancy" crisis; there's a global vaccine supply crisis.

      • Outside the US, UK, Israel

        Notice what is common between those countries? That is due to leadership: those countries had strong leaders who figured out what to do in regards to obtaining the vaccines. By the way, these are the same leaders that you guys shit on every day here on Slashdot.

        • by Rei ( 128717 )

          What they "have in common" is that the US is home to Pfizer and Moderna, the UK is home to AstraZeneca, and Israel got a sweetheart deal from Pfizer for a herd immunity study (we tried in Iceland but our COVID rates were too low :P). Some other countries also struck deals for large amounts of vaccine from Sinopharm (Hungary, Bahrain, UAE, Chile, Serbia, etc), but fat lot of good it's done them; their COVID rates are terrible. Sinovac appears to be a major flop.

        • Re: (Score:2, Flamebait)

          by DarkOx ( 621550 )

          Right and in the US we have a lot of supply because of Operation Warp Speeds strings - Thanks Donald Trump.

          This the problem with the left. When their moon beams fail to materialize its always due to some externality. This is true at a personal level and political level. Its never because they did not work hard enough, because they were wrong, because they just are not talented enough etc - its always someone or something however nebulous that is at fault

        • by Jamu ( 852752 )
          With regard to the UK, I've not heard anyone shit on Kate Bingham.
      • Yes, certainly. I didn't mean to imply that low vaccination rates elsewhere are due to hesitance. (The only arguably exception there is France where vaccine hesitance seems to be playing a minor part.) Yes, the main issue outside most of those locations is supply.
  • by rsilvergun ( 571051 ) on Friday April 16, 2021 @09:14AM (#61280288)
    and I was fully expecting to need a shot for these COVID variants. Be nice if they can combine them, but I'll live if they can't (literally as well as figuratively).

    What's driving me nuts is the number of people who are saying they're not going to get the vaccine because they still have to wear masks and social distance for an undetermined period of time. These are grown adults and I don't think it's unreasonable to say they're acting like children.
    • Re: (Score:2, Insightful)

      by sinij ( 911942 )

      What's driving me nuts is the number of people who are saying they're not going to get the vaccine because they still have to wear masks and social distance for an undetermined period of time.

      I think you are hearing what you want to hear, not what is likely being said. What I hear in private conversations, because I am not out to uncover heretics or score outrage likes on the social media, is along the lines of "what the point of getting everyone vaccinated if everyone continues acting as if nobody is vaccinated". Meaning, the complaint isn't about vaccinations but about lack of return to normalcy for vaccinated people.

      • by DamnOregonian ( 963763 ) on Friday April 16, 2021 @10:05AM (#61280600)

        I think you are hearing what you want to hear, not what is likely being said. What I hear in private conversations, because I am not out to uncover heretics or score outrage likes on the social media, is along the lines of "what the point of getting everyone vaccinated if everyone continues acting as if nobody is vaccinated". Meaning, the complaint isn't about vaccinations but about lack of return to normalcy for vaccinated people.

        That's literally what he said.
        The misunderstanding appears to originate with you.

        Even with your reformulation of his statement, I agree with his conclusion.
        People who are deciding not to vaccinate because, "what's the point if we're not going to return to normalcy" are still acting like children.

        • by sinij ( 911942 )
          You unwillingness to understand what people are complaining about is either politically motivated or rooted in a neurological condition. You can relax, very few people take position of "lets not get vaccinated". My unscientific guess is that at least 80% of population are willing to get vaccinated and that should be enough for us to get to herd immunity, considering that at least 10-30% of the remaining 20% are going to be naturally "vaccinated" to COVID after getting ill and recovering.
      • I think you are hearing what you want to hear, not what is likely being said. What I hear in private conversations, because I am not out to uncover heretics or score outrage likes on the social media, is along the lines of "what the point of getting everyone vaccinated if everyone continues acting as if nobody is vaccinated". Meaning, the complaint isn't about vaccinations but about lack of return to normalcy for vaccinated people.

        This is very well put. Many of these people just want to know when they can start planning the future of their businesses, their families, their children's or their educations. They want to know when the goal posts will stop moving.

      • by Sumus Semper Una ( 4203225 ) on Friday April 16, 2021 @10:53AM (#61280898)

        What's driving me nuts is the number of people who are saying they're not going to get the vaccine because they still have to wear masks and social distance for an undetermined period of time.

        the complaint isn't about vaccinations but about lack of return to normalcy for vaccinated people.

        That points to a fundamental lack of understanding. The idea that a vaccine makes you "immune" to a virus is misleading. Vaccines train the body to recognize the virus and mount a quick immune response. The response is not immediate and not foolproof, but in general it should lead the vaccinated person to have greatly lessened symptoms (or even no symptoms) when they are exposed to the virus and a shorter time where they are spreading the virus. What it does NOT mean is that people who are vaccinated are bulletproof against the vaccinated virus and can walk around in an environment of lots of infected people with it just bouncing off of them with no effect. They can still be infected (and please note that there is a difference between infected and symptomatic), can still get sick, still have an outside chance of having serious complications, and, most importantly, can still spread the virus.

        Once enough people are vaccinated, the transmission rates drop so low that the chances of the virus finding an unvaccinated or vaccinated but immune compromised host to live in long enough to jump to enough new viable hosts to cause an outbreak become negligible. That's the outcome we're looking for. Refusing to vaccinate because it doesn't mean you can immediately resume a pre-COVID lifestyle or complaining that being vaccinated doesn't mean you are exempt from COVID precautions as the vaccines roll out both completely miss the point and are counterproductive to the stated goal.

        This simplistic idea that "you got vaccinated, so why do you care that I didn't since you're immune?" and "I'm vaccinated, so I don't have to worry about the virus" is how Measles started to break out in the US after being practically eliminated for decades.

    • If everyone was on board with masking and cooperating from the outset we could be on the honor system but these folks have just ruined any semblance of common good for the time being.

      That said I am fairly sure there have been good results with combining Pfizer/Moderna since they are very similar and I believe there is study into mixing and matching the JJ/AZ vaccines with those others as well.

    • What's driving me nuts is the number of people who are saying they're not going to get the vaccine because they still have to wear masks and social distance for an undetermined period of time.

      Given the criteria to stop masking and social distancing are high vaccination rates, these people are setting up society for an infinite while loop. Sooner or later there will have to be an interrupt...

      • that gets past the current vaccines. Then we'll make a new vaccine, but by the time that's out we'll have a new variant that gets past *that* vaccine.

        The only way you win an arms race against a virus is with total destruction. And the only way you do that is with extremely high vaccination numbers (85-95%) coupled with widespread precautions (social distancing, masks, handwashing, etc, etc). You can't win a war with half measures.
    • by Rei ( 128717 )

      Sorry to see you getting trolled here. I don't know you or your politics or anything else about you, but I do think it's sad that Slashdot has become home to so many stalkers and trolls. :(

      • You literally have the sig "Is Donald Trump a racist? I'll let you decide 'Yes' for yourself." and YOU say WE are trolling? Seriously, Rei you are incredibly pathetic. Is everyone in Iceland like that? It isn't trolling, I am calling you fakers out for what you are.
    • by DarkOx ( 621550 )

      Well if that is really their reason for not getting the vax; that is childish. Not all of us refuse it for that reason though. Some of us have actual principles. Like I don't use the products of abortion - which every single available covid vaccine is. Sorry I don't want to profit even in terms of my own safety from the murder of someone else. Doubly so when that someone else was entirely innocent and without any capability to defend themselves. Its unethical. You can protect yourself, you can isolate if

  • People who recovered from the original SARS have "significant" antibody levels up to 17 years later.
    https://pubmed.ncbi.nlm.nih.go... [nih.gov]

    Caveat 1: extrapolation is always hazardous and biology is super-messy.
    Caveat 2: We got the original SARS under control and it's not evolving resistance now. SARS COV 2 is. We already know that antibodies against one variant are only partly effective against others.

    Encouraging: "partly effective" simply means that larger numbers are needed so that when one weakly bound antibody falls off a spike protein, there will be another to take its place. The vaccines produce high antibody levels.

    Encouraging: the immune system has other strings to its bow.

    We'll know for sure in a year.

  • by BAReFO0t ( 6240524 ) on Friday April 16, 2021 @05:42PM (#61282514)

    Within a year, it can't handle the level of mutation anymore.

    Fair enough, but it's not really much of a vaccine then... I expect a vaccine to last the usual 10 years.

    I really don't think Biontech are deliberately doing this to make continuous profits.
    But I really think that is the only purpose in life for Pfizer.

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