Johnson & Johnson's Covid-19 Vaccine Produces Strong Immune Response in Early Trial (newsweek.com) 48
Newsweek reports:
Pharmaceutical manufacturer Johnson & Johnson announced Friday that early trials of a COVID-19 vaccine showed a 98 percent success rate in showing a boost in the immune system. According to research from Johnson & Johnson, the vaccine enabled 98 percent of those who took it to create antibodies that fight off the coronavirus infection. Those neutralizing antibodies were present 29 days after receiving the vaccination...
Currently, four U.S. vaccines are in the final trial stages. Vaccines from other pharmaceutical companies such as Pfizer and Moderna are administered in two doses while the Johnson & Johnson vaccine only requires one.
"Based on the current results, Johnson & Johnson on Wednesday kicked off a final 60,000-person trial," reports Reuters, "which could pave the way for an application for regulatory approval. The company said it expects results of that so-called Phase 3 trial by the end of the year or early next year."
Currently, four U.S. vaccines are in the final trial stages. Vaccines from other pharmaceutical companies such as Pfizer and Moderna are administered in two doses while the Johnson & Johnson vaccine only requires one.
"Based on the current results, Johnson & Johnson on Wednesday kicked off a final 60,000-person trial," reports Reuters, "which could pave the way for an application for regulatory approval. The company said it expects results of that so-called Phase 3 trial by the end of the year or early next year."
Re:Big pharma (Score:4, Informative)
Re:Big pharma (Score:4, Insightful)
And under the current alleged administration, it won't matter if they approve a vaccine, no one will trust them.
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Sadly, there are those that will trust an "approved" vaccine. If that vaccine is approved more quickly than the science behind it would otherwise allow, there are one of two outcomes, good and bad. A mixed outcome means failure, of course.
That portion of the populace will do what the gov tells them, like it or not. There are also some people that are truly desperate to get out from under what otherwise amounts to 24/7 quarantine, because they have conditions that would probably kill them if they caught COVI
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I'm in the "any vaccine is better than no vaccine, within reason" camp. If it passed stage 2 option trials, I'll take it. Not just for mitigating COVID-19, but ensuring I don't spread it to anyone. Of course, this isn't for everyone, especially older people or people with risk factors, but in this case, something is better than nothing.
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There is a case where a vaccine candidate hurts people and offers no protection, a false comfort. Where case this exists, and it's probable, Nothing is better than Something.
good to see such a long delay (Score:2)
I still want to know what really happened to all the Russian elite and their relatives who got a jab after trial of dozens. Was it useless? Did some get infected by the shot? Did it work. Insanely irresponsible and not how vaccines are developed.
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You can't get infected by a COVID-19 vaccine.
You can't get infected with COVID-19, but the Sputnik, Cansino and Astra Zeneca are using a vector based vaccine where they are modifying the common cold virus to include SARS COV2 spike protein DNA. Three candidates rely on weakened human adenoviruses to deliver the recipe for the spike protein of the pandemic coronavirus, while two use primate adenoviruses and one uses measles virus. [the-scientist.com]
So, technically you are getting a mild infection. The small pox vaccine also gives you a mild infection.
This place is full of anti-science idiots.
Idiots and asshole
Re:good to see such a long delay (Score:4, Informative)
You can't get infected by a COVID-19 vaccine.
You can't get infected with COVID-19, but the Sputnik, Cansino and Astra Zeneca are using a vector based vaccine where they are modifying the common cold virus to include SARS COV2 spike protein DNA.
I wouldn't call adenovirus the common cold. Most colds are caused by a rhinovirus. Even fewer colds are caused by adenovirus than coronavirus, and I don't think anybody wants us adding a spike protein to the latter. :-D
Also, as you noted later in that paragraph, the adenovirus used by AstraZeneca is a chimpanzee adenovirus, not a human adenovirus, which makes it even further from the common cold.
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Re:good to see such a long delay (Score:4, Insightful)
You can't get infected by a COVID-19 vaccine. This place is full of anti-science idiots.
What are you talking about? Vaccines absolutely can cause the very disease they are trying to protect against, which is why it is so important to test them properly. In 1955, 200,000 children were given a polio vaccines which led to 40,000 cases of polio. This led to many of the federal regulations which make modern vaccines so effective and safe today. We absolutely need to ensure our Covid-19 vaccines are safe because a rushed vaccine could be far more dangerous than the disease itself.
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You can't get infected by a COVID-19 vaccine. This place is full of anti-science idiots.
What are you talking about? Vaccines absolutely can cause the very disease they are trying to protect against,
And this is what makes you an anti-science idiot. No, you cannot get infected with COVID-19 by the COVID-19 vaccine. The polio-vaccine you are quoting was generated differently than what is done today and with far less understanding. _Back_ _then_ a vaccine could give you what it was supposed to protect again. That time is long over.
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You can't get infected by a COVID-19 vaccine. This place is full of anti-science idiots.
What are you talking about? Vaccines absolutely can cause the very disease they are trying to protect against, which is why it is so important to test them properly. In 1955, 200,000 children were given a polio vaccines which led to 40,000 cases of polio. This led to many of the federal regulations which make modern vaccines so effective and safe today. We absolutely need to ensure our Covid-19 vaccines are safe because a rushed vaccine could be far more dangerous than the disease itself.
YES IN 1955!!!! I hate it when someone argues that point. It is absurd. It is before computers, the internet, DNA mapping... Ya think we have made some progress since then? Maybe?
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YES IN 1955!!!! I hate it when someone argues that point. It is absurd. It is before computers, the internet, DNA mapping... Ya think we have made some progress since then? Maybe?
I would hope it depends on what the purpose of someone bringing it up is. If it is to claim vaccines are dangerous and should be avoided, that is absurd. If it is to remind people how important vaccine research is to get right, including the high level of testing we do for years which is above and beyond what we did in 1955, then I would hope you find that valuable to remember and realize. It would be dangerous to assume computers, DNA mapping, etc. mean we are so good at this now that proper trials aren't
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You are wrong. There are various vaccines, and with *some* of them you can't get infected with the disease that they are protecting you against. With others it shouldn't happen. With others it's an infection with an intentionally weakened strain. Etc. The COVID vaccines are being developed with several different methods, and each one has it's failure modes. And some of them have brand new failure modes never seen before. (I'm particularly thinking of one of the RNA vaccines here.) With careful manag
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You are the one ignorant of science and history. People have been infected by vaccines, look up polio vaccine. There are other examples, from attenuated virus batches that also had live, to more complex systems that included live modified virus.
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If it's an attenuated virus vaccine, you can.
In this case, the Russian vaccine is a "viral vector" vaccine -- it's a pair of human adenovirus genetically engineered to produce a SARS-COV-2 antigen. You get one engineered virus on the first day and the second virus strain as a booster three weeks later. They don't *work* unless you get infected, but the infection is supposed to be harmless.
The adenoviruses from which these vaccines are engineered typically produce mild cold symptoms, but could conceivably
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I still want to know what really happened to all the Russian elite and their relatives who got a jab
They all got autism.
It turns out that Jenny McCarthy was right.
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Stage 1 is tiny though, they should not skip any stage and put into their own children, that's dangerous and reckless. People sometimes get maiming infections from vaccine trials; the particular type Russia is using is especially risky for weird things to happen.
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Latest news was Moscow was getting nailed with new infections. If they had a vaccine, and could produce it in mass quantities, and it worked, and they could deliver it properly, then this shouldn't be happening. Somewhere in that trail is Russian failure.
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I still want to know what really happened to all the Russian elite and their relatives who got a jab after trial of dozens. Was it useless? Did some get infected by the shot? Did it work. Insanely irresponsible and not how vaccines are developed.
Probably nothing happened. They will have been careful nonetheless so probably no infections. They were too few to see adverse reactions, unless they are exceptionally likely with that vaccine.
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The KGB, the FBI and the CIA are all trying to prove they are the best at catching criminals. The Secretary General of the UN decides to set them a test. He releases a rabbit into a forest, and each of them has to catch it. The CIA people go in. They place animal informants throughout the forest. They question all plant and mineral witnesses. After three months of extensive investigations, they conclude that the rabbit does not exist. The FBI goes in. After two weeks with no leads they burn the forest, killing everything in it, including the rabbit, and make no apologies: the rabbit had it coming. The KGB goes in. They come out two hours later with a badly beaten bear. The bear is yelling: "Okay! Okay! I'm a rabbit! I'm a rabbit!"
Okay! Okay! It's a vaccine! It's a vaccine!
The more, the merrier (Score:2)
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less well tolerated in the elderly, who really are the ones that need it badly.
The primary benefit of vaccines is herd immunity, which will benefit the elderly even if they are not vaccinated.
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It's still not certain that herd immunity is even possible with this virus. There are other corona viruses for which it isn't possible, including some varieties of the "common cold".
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Well, if you can vaccinate all medical personel and care taker. That would already provide significant health outcomes for the elderly.
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However I have heard that there are indications that this will be less well tolerated in the elderly, who really are the ones that need it badly.
They are the ones who are at most risk, but everyone needs it badly. If you can get our kids enough immunity so they can go to school without bringing the virus home, you have already made it safer for their grandparents.
ADE? (Score:3)
Now we have to make sure nCov-19 doesn't trigger ADE. If it does, the conserved-region "common cold" beta-coronavirus vaccines ought to be effective enough.
Those should have started trials in May too. Parallelism, people.
ADE: Adverse Drug Event (Score:2)
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ADE also = Antibody Dependent Enhancement [nature.com].
Antibody-dependent enhancement (ADE) of disease is a general concern for the development of vaccines and antibody therapies because the mechanisms that underlie antibody protection against any virus have a theoretical potential to amplify the infection or trigger harmful immunopathology.
ADE triggered by repeated influenza vaccinations may already have played a role increasing the lethality of Covid-19 in certain countries like the USA and the UK where influenza va
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What would help this effort is sourcing additional flu vaccination statistics (% for over-65s vaccinated in each year for the past 20 years) from other countries for the past 20 years.
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The possible underlying mechanism may be that repeated challenges to the immune system by vaccination potentiate the impact of COVID-19 on vaccinated populations. This is not implausible--the recent paper describes how historical viral infections can make certain populations susceptible to the current pandemic:
Antibody Dependent Enhancement Due to Original Antigenic Sin and the Development of SARS.
https://www.ncbi.nlm.nih.gov/p... [nih.gov]
i abandoned both emacs & vim (Score:1)
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keep us informed.
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Wrong thread, Butfucker*.
* Idiocracy reference
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Misleading headline (Score:3)
The only "success rate" that matters is peoples actual response to the actual virus not measurements of antibodies.
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Unfortunately, the kind of result mentioned in the article is all we've got from any of the candidate vaccines right now.
I'm eagerly awaiting results from any of the ongoing trials, but I feel like its been radio silence on that front since July.
Announcement timed for election (Score:2)
Somebody pressured these companies to announce progress... any progress... but particularly optimistic full speed ahead damn the torpedos type progress... just in time for the election. Somebody did that, yes somebody did.
Doesn't change the fact that Trump is guilty of mass negligent homicide.
antibodies (Score:2)
yep (Score:1)
Toxic Beauty (Score:1)