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Medicine

Hydroxychloroquine Does Not prevent Covid-19 Infection if Exposed, Study Says (statnews.com) 280

The malaria drug hydroxychloroquine did not help prevent people who had been exposed to others with Covid-19 from developing the disease, according to the results of an eagerly awaited study that was published Wednesday in the New England Journal of Medicine. From a report: Despite a lack of evidence, many people began taking the medicine to try to prevent infection early in the Covid-19 pandemic, following anecdotal reports it could be effective and claims by President Trump and conservative commentators. Trump, too, said he took hydroxychloroquine to prevent infection. But the new study, the first double-blind randomized, placebo-controlled trial of hydroxychloroquine, found otherwise. "I think in the setting of post-exposure prophylaxis, it doesn't seem to work," said Sarah Lofgren, an assistant professor at the University of Minnesota who is a co-author of the study. Other studies of hydroxychloroquine are ongoing. Also Wednesday, the World Health Organization said it is resuming a clinical trial testing hydroxychloroquine as a treatment after pausing it over safety concerns.
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Hydroxychloroquine Does Not prevent Covid-19 Infection if Exposed, Study Says

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  • So it doesn't help prevent infection, doesn't help when people are infected, doesn't prevent death. How much more money and time are we going to waste on this quackery? And why? Just because a senile orangutan promoted it? Let's spend the time and money on something that has a chance of working.

    • You just have to take just after being infected, not before, and not too long after, with 20 other things that will make it not work if not in perfect balance, and stand on your head under the full moon. All these studies are wrong because they didn't test super specific combo x at precise time y!
    • Let's spend the time and money on something that has a chance of working.

      We are, there are hundreds of other drugs in trial for COVID.

      And why?

      Because HQC helps to suppress the cytokine storm that was theorized to be what killed people with coronavirus. That is the hypothesis.

  • Wow great Slashdot mods.

    This morning I sent in a story about how the WHO is restarting testing [financialexpress.com], because their prefvious study was flawed, but instead they deci9de to gho with one more story about HCQ not working.

    • RTFA (Score:3, Informative)

      by rsilvergun ( 571051 )
      It's not working for prevention. The WHO is going to run another study for treatment.

      Given that the Spanish study is still out there and it still shows that at best unsafe doses are necessary to have an effect on the virus the second WHO study is unlikely to bear fruit. Still, it needs to be done.
      • by gweihir ( 88907 )

        Indeed. The aims at this time are to reliably rule out any benefits, but that still needs to be proven to sound standards, i.e. double-blind.

        • This was a double blind study. But yes we need double blind studies for proving whether or not it reduces deaths in intensive care patients.

      • It's not working for prevention. The WHO is going to run another study for treatment. Given that the Spanish study is still out there and it still shows that at best unsafe doses are necessary to have an effect on the virus the second WHO study is unlikely to bear fruit. Still, it needs to be done.

        Some of the negative studies are now being questioned by the Lancet and the New England Journal of Medicine, two highly regarded medical journals.
        https://www.statnews.com/2020/... [statnews.com]

    • Comment removed based on user account deletion
  • Originally the combination of azithromycin and hydroxychloroquine was posited to help patients recover faster.

    https://www.biospace.com/artic... [biospace.com]

    https://techcrunch.com/2020/03... [techcrunch.com]

  • On the other hand (Score:5, Insightful)

    by hey! ( 33014 ) on Thursday June 04, 2020 @01:15PM (#60145524) Homepage Journal

    there are questions being made about the reliability of the database used in the Lancet study for hospitalized patients a couple of weeks ago, although these questions don't *necessarily* invalidate the conclusions.

    Welcome to science folks. If you aren't comfortable with uncertainty, it's not for you.

    • by gweihir ( 88907 ) on Thursday June 04, 2020 @01:37PM (#60145616)

      Well said. It not only takes a scientific mind to produce Science, it also takes one to understand it, especially when there is real time pressure and uncertain results need to be used as nothing better is available. From a scientific point of view, these conditions also produce the fastest advances, as you cannot play it safe anymore. In retrospect, they also produce the most false theories and failed approaches, but that is expected.

  • If it did prevent infection, it would be called "vaccine", not "medicine".

  • There is much anecdotal evidence of many frontline doctors and nurses taking hydroxychloroquine as a prophylactic for weeks before Trump even mentioned it. Where do you think he got the idea?

    Look, I don't know if it works or not. There have been studies showing it does and it doesn't. Some of the "doesn't work" studies look like they under dubious circumstances at best. All of this is new. But it's shit like this that's infuriating. Trump isn't selling or making hydroxychloroquine. But every Trump ha

    • But every Trump hater in the world wants to frame it as if Trump just started naming hydroxychloroquine out of the blue and started prescribing it to the public.

      And if he had prescribed Eye of Newt, Trump lovers would be fawning over his amazing medical knowledge. So it certainly works both ways.

    • It being preventative has always been a theory but it's not matter much because the risks of it are very low so little lost if you take it anyway.

      Where it has specifically shown some possible promise which again was never stated for certain is when it comes to the progression of the virus to the point where it destroys the lungs.
    • "Trump isn't selling or making hydroxychloroquine"

      Trump is invested in a company which makes it. Consequently he is doing both by proxy.

      • This?

        "Business Insider followed the paper trail and concluded that the holding has a maximum value of around $1,300, only slightly larger than similar holdings by Trump funds in Google parent Alphabet, FedEx, and the French bank BNP Paribas.

        Here is the logic:
        The Dodge & Cox holdings are mentioned in this disclosure form, logged with the US Office of Government Ethics in May 2019.
        Each of three family funds list a holding in the Dodge & Cox International Stocks Fund, valued between $1,000 and $15,000.

    • There is much anecdotal evidence of ...

      There is a common saying in the world of scientific research: "The plural of "anecdote" is not "data".

  • by Citizen of Earth ( 569446 ) on Thursday June 04, 2020 @01:37PM (#60145618)
    The headline doesn't say anything about taking the Hydroxychloroquine with Zinc. The Hydroxychloroquine helps the Zinc get into your cells and it's the Zinc that helps to keep the COVID-19 out. Any testing without Zinc is just murdering people to try to spite Trump.
    • A Dutch doctor did a small scale trial with these 2 components and a 3rd (not sure what it was). Very promising results, but only a very small study and not a double blind one. An MP submitted a proposal for a larger scale study, but it was shot down by parliament as a "bill for snake-oil", because part of the proposed treatment is "Trump's cure".
    • by cirby ( 2599 )

      Doing a search for "zinc" on the paper itself returns zero results.

      Since the claims for prophylaxis are for HCQ + azithromycin + zinc, it looks like someone intentionally did a broken study to get the "correct" result.

      • Re:Show me the Zinc! (Score:4, Informative)

        by jeff4747 ( 256583 ) on Thursday June 04, 2020 @02:22PM (#60145868)

        It's not mentioned in the paper because they did not give zinc to the subjects. However (bolded for emphasis):

        Approximately 12% of those given hydroxychloroquine developed Covid-19, compared to 14% who were given the vitamin folate as a placebo. There was no further benefit among patients who chose to take zinc or vitamin C. Nearly 40% of patients on hydroxychloroquine experienced side effects such as nausea, upset stomach, or diarrhea. However, the study did not see a significant increase in disturbances of heart rhythms, or an imbalance of deaths.

    • All you had to do was read TFS.

      Approximately 12% of those given hydroxychloroquine developed Covid-19, compared to 14% who were given the vitamin folate as a placebo. There was no further benefit among patients who chose to take zinc or vitamin C. Nearly 40% of patients on hydroxychloroquine experienced side effects such as nausea, upset stomach, or diarrhea. However, the study did not see a significant increase in disturbances of heart rhythms, or an imbalance of deaths.

    • I think what may be more relevant is to run blood panels on patients to correlate success and failure with with blood levels of certain elements including Zinc. It doesn't hurt the study to draw blood, and it may give some suggestion as to why it fails in some people ( low blood levels of Zinc ).

    • So your theory is that there is a conspiracy where this drug is purposely being given in trials without Zinc? Could be true, but why?
      • by dmt0 ( 1295725 )

        Follow the money. How much does HCQ cost? Go look at stock prices of leading covid vaccine contenders.

    • The headline doesn't say anything about taking the Hydroxychloroquine with Zinc.

      Oh today it's zinc? I'm sure tomorrow it will be garlic, or whatever else the pro hydroxychloroquine crowd will attempt to mix it with to try and somehow prove that they didn't completely jump the gun on completely unfounded claims like morons.

  • There's probably a more important story that's being missed, which is a journal retracting an article claiming that masks were ineffective [acpjournals.org].
  • by schwit1 ( 797399 ) on Thursday June 04, 2020 @01:48PM (#60145690)

    https://publichealth.yale.edu/... [yale.edu]

    Does hydroxychloroquine have the potential to be a “game-changer” in the fight against this pandemic?

    HR: Hydroxychloroquine alone is not the whole story. It needs to be combined with azithromycin or doxycycline and probably with zinc to make it most effective. The game changer is to aggressively treat people as soon as possible, before they are hospitalized, to keep them from becoming hospitalized in the first place. Hydroxychloroquine plus the other medications is what we know about now. In a few months we may have data on other medications that also work. We just have to start with something now.

  • Make him take as much hydroxychloroquine as he wants! If he wants 10x dosage, by all means!
  • by nashv ( 1479253 ) on Thursday June 04, 2020 @04:42PM (#60146386) Homepage

    The entire story with choloroquine phosphate or hydroxychloroquine has been a distraction mess. Nobody - absolutely nobody, who knows what chloroquine does (cell biologists, not medical doctors) expected chloroquine to work after exposure to the virus.

    Chloroquine prevents endocytosis and autophagy, as is expected to work BEFORE exposure, to lower the risk of infection. And every single study so far focuses on the after-exposure effects, and some even on when full-blown disease is ongoing. Of course it slows insignificant effects.... it's like throwing a plastic sheet on your car to keep it dry AFTER it has been parked in the rain overnight. That's not how plastic works, stupid.

    The main difficulty is that to conduct a pre-exposure study is extremely risky for the researchers. You'd have to put a group of people on chloroquine and a group of people on placebo and then hope that some of them catch COVID19...so you can get your data. In the current climate of half-baked measures and people either following social distancing or not, to various degrees, the data at the end of the trial will be a mess. Essentially, any researchers who undertake such a trial are doomed to scientific failure due to poor data quality.

    Much easier to take people who are already exposed or infected...because you can identify them. This is how stupid statements from authoritative figures derail and corrupt the scientific process.

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