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Medicine

Doctors Are Hoarding Unproven Coronavirus Medicine By Writing Prescriptions For Themselves and Their Families (propublica.org) 236

An anonymous reader quotes a report from ProPublica: A nationwide shortage of two drugs touted as possible treatments for the coronavirus is being driven in part by doctors inappropriately prescribing the medicines for family, friends and themselves, according to pharmacists and state regulators. Demand for chloroquine and hydroxychloroquine surged over the past several days as President Donald Trump promoted them as possible treatments for the coronavirus and online forums buzzed with excitement over a small study suggesting the combination of hydroxychloroquine and a commonly used antibiotic could be effective in treating COVID-19.

"It's disgraceful, is what it is," said Garth Reynolds, executive director of the Illinois Pharmacists Association, which started getting calls and emails Saturday from members saying they were receiving questionable prescriptions. "And completely selfish." Reynolds said the Illinois Pharmacists Association has started reaching out to pharmacists and medical groups throughout the state to urge doctors, nurses and physician assistants not to write prescriptions for themselves and those close to them. "We even had a couple of examples of prescribers trying to say that the individual they were calling in for had rheumatoid arthritis," he said, explaining that pharmacists suspected that wasn't true. "I mean, that's fraud." In one case, Reynolds said, the prescriber initially tried to get the pills without an explanation and only offered up that the individual had rheumatoid arthritis after the pharmacist questioned the prescription. In a bulletin to pharmacists on Sunday, the state association wrote that it was "disturbed by the current actions of prescribers" and instructed members on how to file a complaint against physicians and nurses who were doing it.
It's important to note that there is little evidence that the drugs work to treat coronavirus, although clinical trials are underway to find out.

The report mentions a man in his 60s who died after ingesting a version of the chloroquine commonly used to clean fish tanks. "The man, who thought he might have COVID-19, took a small amount of the substance in a misguided effort to treat his symptoms," reports ProPublica. "His wife was also hospitalized after taking the substance but survived."
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Doctors Are Hoarding Unproven Coronavirus Medicine By Writing Prescriptions For Themselves and Their Families

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  • by OrangeTide ( 124937 ) on Tuesday March 24, 2020 @05:04PM (#59868092) Homepage Journal

    Any vaccine or treatment that reduces viral load should be prioritized for those who are on the front lines. And logically that can be extended to their immediate family, as letting a doctor's spouse get sick would mean that doctor may have to choose to stay home and provider care or continue working.

    That doctors are doing this, even if it is a minority, says a lot about the lack of confidence they have in our health care system to manage this crisis. Don't be angry at doctors, take it as a warning. They are scared too.

  • FUCK PROPUBLICA.ORG
  • by hawguy ( 1600213 ) on Tuesday March 24, 2020 @05:22PM (#59868152)

    What do they expect when the top expert recommended it and said it's a game changer in the treatment of COVID-19?

    "HYDROXYCHLOROQUINE & AZITHROMYCIN, taken together, have a real chance to be one of the biggest game changers in the history of medicine," Trump said in a series of tweets on Saturday. "Hopefully they will BOTH be put in use IMMEDIATELY. PEOPLE ARE DYING, MOVE FAST,"

  • As recently as yesterday, experts were affirming that as a novel disease, there is no current human immunity, no treatment and no vaccine.

    Who's right?

    • No. Not that there weren't possible treatments (because antivirals do exist) but rather that there is no known "herd immunity" present in the application.

    • In a single news cycle I can hear "experts" tell me definitively that this will last a month, or a two months, or 18 months, or forever. Even at high levels they seem to be pulling numbers from asses.

    • Comment removed based on user account deletion
  • When you look at risk/reward, there is pretty good evidence that we should be prescribing hydroxychloroquine more frequently and in fact, there should be preparation to ramp up production.

    As for the man who died, that would be a combination of wrong dose and taking fishtank cleaner rather than the actual pharmaceutical.

  • Mylan and Novartis are greatly ramping their production of hydrochloroquine (trade name Plaquenil) without considering the small scale hoarding. Big pharma thinks there's something to this, why wouldn't physicians?

    That also means that this is a short term supply chain issue and not a longer term shortage for people having trouble finding their meds. Those kinds of shortages have been more common in recent years as numerous drugs have had short term recalls.

    https://www.novartis.com/news/... [novartis.com]
    https://www.prnews [prnewswire.com]

    • by dfghjk ( 711126 )

      "Big pharma thinks there's something to this, why wouldn't physicians?"

      Because it's not physicians' jobs to speculate on treatments for conditions they've never seen before?

  • If you go read the reddit subs for Lupus and Rheumatoid Arthritis, they are pissed that the medicne they take hydroxychloroquine is the new hotness for Covid-19. These people have literally been taking the medicine for years and now they can't get it because people are hoarding it. The dude who took the fish tank cleaner was an idiot. Otherwise, the drug is pretty safe and is used by a lot of people.

    • The drug is absolutely not safe. It is packed in pills for a daily dosage. 3 pills are most of the time deadly. Only responsible people can use the drug safely ...

      The internet, the time with every information at your fingertips. The time with the most stupid people ever occupying the planet ... oh the oxymoron.

  • Although in my case the quinine is in a gin & tonic.

    • Wow that's amazing, I've been doing the exact same thing! Well, almost exactly. I mean, if you replace "gin" with "pepsi" and "tonic" with "chips", it's exactly the same thing!

  • by 140Mandak262Jamuna ( 970587 ) on Tuesday March 24, 2020 @06:22PM (#59868352) Journal
    We had nursery rhymes back in the day in India. "There you see, a mynah!, Hospital has quinaa, Here comes my nynaah (daddy) ". ironically the last line ends as, "I am going to China"

    Post offices used to dispense these quinine tablets for free among the mosquito infested regions. My grandpa was a postmaster, and mom remembers distributing it for free during the malaria season.

    So it is just a matter of days or weeks before India ships a few tons of this stuff.Cheaper than dirt.

    But if you dont have malaria, over dosing on this is dangerous. And the reports of its efficacy against Covid-19 is just anecdotal. This is an anti-parasite medication against microscopic multi cellular parasite. Covid-19 does not even have two strands of RNA to make DNA. It is possible it works by attacking the RNA of the parasite. But still ...

    • by spitzak ( 4019 )

      There are suggestions it interferes with the bonding mechanism that the virus uses to invade the cells. I suspect this is entirely unrelated to how it treats other diseases, but it is a simple enough chemical that it seems likely it may do many things. There are links above to a Nature article that seems pretty informative and unbiased.

      Big problem to me is that it sounds like the chemical attaches to the human cells to block the virus, not to the virus. I would rather not have something that has to cover al

  • Out them in prison. After about a dozen public arrest, that shit will slow considerable.

  • by DRichardHipp ( 995880 ) on Tuesday March 24, 2020 @07:46PM (#59868600)

    In order to understand how chloroquine and hydroxychloroquine are believed to inhibit the SARS-CoV-2 virus, we first need to review how the virus itself works.

    When a coronavirus binds to a cell, it transfers is single strand of RNA inside the cell. Then ribosomes read the RNA and use it to make proteins. The first protein made by the coronavirus RNA is call RNA-dependent RNA polymerase (RdRP). The RdRP protein catalyses RNA replication. In other words, RdRP takes one strand of RNA and makes a (complementary) copy of it. It does this over and over, and in that way generates lots of new coronavirus RNA, which after being packaged in other proteins made by the viral RNA, forms new virus particles that go on to infect other cells.

    The proposed mechanism of action of chloroquine is that it (indirectly) inhibits the action of RdRP. This makes it harder for the virus to replicate and spread, and thus making it harder for the virus to get ahead of the victims immune system.

    Chloroquine inhibits RdRP by increasing the concentration of zinc inside cells. Inside the cells, zinc forms (among other things) zinc triposphate. It appears that when RdRP is replicating an RNA strand, if it needs an adenosine triposphate as the next link on the RNA strand, but a zinc triposphate is drifting by at the right moment, the RdRP will stick in the zinc triposphate where the adenosine ought to be. This gums up the mechanism and causes the RNA replication to stop. Or, at least, that is the latest theory.

    RdRP is not a part of normal cell metabolism, so inhibiting it does not cause other problems. There are other (sometimes severe) side effects to chloroquine, however, so it should not be taken except under knowledgeable and expert guidance.

    There is another drug, favipiravir, that also shows promise against coronavirus in early trials. Favipiravir works similarly to chloroquine in that it inhibits or impedes the activity of RdRP, though exactly how it does this is less clear.

  • Just a minor flu. That were the doctors word on national tv here in Denmark 3 years ago. They had 8 doctors taking calls from viewers. Less than one week later everything has to shut down.

    Fantastic.

  • 1) He actually trusted Trump. Strike 1.

    2) He ate something made for fish parasites. I mean, really? How effin stupid can you be? Strike 2.

    3) He didn't bother asking his doctor if he had the virus, he just ate fish food based on advice from Trump. Strike 3.

    Stupid is as stupid does.
  • Toilet paper hoarders don't look so bad in comparison now, don't they?

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