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Science Technology

Chinese Scientists Regrow Tooth Enamel In 48 Hours With Phosphate Gel (newscientist.com) 46

hackingbear writes: A team of researchers at China's Zhejiang University were able to create a gel that makes tooth enamel repair itself, they wrote in the science journal Science Advances, a development that could spell the end of fillings as an (unreliable) method to repair cavities which are one of the most prevalent chronic diseases in humans. The gel succeeded in making the enamel repair itself within only 48 hours. Though it now only manages to generate a layer of about 3 micrometres -- about 400 times thinner than undamaged enamel, the researcher says the gel could be repeatedly applied to build up this repair layer. The team is now testing the gel in mice and hopes to later test it in people.
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Chinese Scientists Regrow Tooth Enamel In 48 Hours With Phosphate Gel

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  • Heck, just sit there with gel on your teeth for 19,200 hours and you're good as new. Way to go, Chinese researchers!

    • by Anonymous Coward
      The only problem is the color of the replacement enamel is hunter's orange.
    • by MrLogic17 ( 233498 ) on Thursday September 05, 2019 @02:37PM (#59162772) Journal

      Or, maybe just add some to toothpaste, along with (or replacing) fluoride.

      Dude, this is the first draft. Give them a minute to fine tune it.

    • The average human lifespan brushing time is probably no where close to that. Hopefully they improve results by changing the formula somehow before jamming that in toothpaste, claiming it does something meaningful, and jacking up the price...
      • by suutar ( 1860506 )

        You are correct. My dentist says I should brush at least 2 minutes at a time, twice a day; over 70 years that's 51135 minutes or 852.25 hours

        On the other hand, for my enamel to survive that long (25,567 days) each 1/400th of its thickness has to last 63 days, so it shouldn't be too hard for the gel to keep up with normal wear and tear.

    • by ceoyoyo ( 59147 )

      They applied the gel once, then dropped the teeth in a solution designed to mimic the mouth. They didn't leave it on continuously.

      So in the spirit of wild extrapolation, brush your teeth for a year or so, and there you go, cavities repaired.

  • I'm a dentist (Score:5, Informative)

    by mark_reh ( 2015546 ) on Thursday September 05, 2019 @02:44PM (#59162804) Journal

    This is great if it works, and applied to decay that hasn't penetrated the enamel it would maybe prevent cavities (assuming you can get the patient to change their self-care habits). In decay that has penetrated the enamel, you still have to take out the decayed tooth structure and you still have to replace that structure, so it isn't the end of fillings but maybe a replacement for some of the materials that are used now.

    • I suddenly remember the old joke...
      What is the difference between a dentist and a sadist?

      The sadist has better magazines in their waiting room.
    • Re:I'm a dentist (Score:4, Interesting)

      by pz ( 113803 ) on Thursday September 05, 2019 @02:57PM (#59162860) Journal

      What about NovaMin (calcium sodium phosphosilicate) that is available in Europe but not the US as a toothpaste ingredient? The claim is that it also repairs damage.

      • Re:I'm a dentist (Score:4, Informative)

        by vandemar ( 82106 ) on Thursday September 05, 2019 @09:56PM (#59164164)

        Novamin is also available in Canada and it does work. With daily use, rough surfaces and even macro sized scratches on the enamel get smoothed over with a hard protective layer over time. I've only ever seen NovaMin on the Sensodyne Repair & Protect toothpaste product line, where the words "Powered by Novamin" are discreetly placed on the box. The same Repair & Protect product line is available in the US with the same packaging, only without the Novamin.

        In Japan, they have the Apagard brand with nano-hydroxyapatite. Pretty much the same compound that makes up the natural enamel, but in particle sizes small enough to easily bond to the tooth surface. It is so effective that they don't even bother adding fluoride to it. You can order it on Amazon or eBay, but you won't find it in stores outside of Japan.

        It makes me wonder why these advances have not made it to the US. Instead, we see lots of toothpaste products marketing themselves as Enamel Defense(TM) or whatever, when it's just the same old fluoride in fancy packaging. It's like they're trying to drown out the real innovation with false marketing, so consumers don't know what to trust anymore.

        • There are three different types of fluoride in toothpastes in the US. It's not all the same fluoride. Trying to figure out the difference is a problem, however.
    • When I was a young kid, (at least from my parents perspective) I had a major ear infection, where my baby teeth didn't have enamel on them. So my baby teeth were prone to cavities, even with multi-daily brushing) Other then just fixing cavities, I could possibly see this as a way to strengthen teeth with less enamel then normal.

    • by EvilSS ( 557649 )
      I'm sure you won't mind the need for patients to come back every 48 hours for 400 treatments either! :)
  • (jumps up three feet)

    See!

    Now, I just have to do that a few more times and I can fly to the Moon!

  • ...can you speed things up a bit?
  • I've never heard of the Science Advances journal before, but at least it appears to be peer reviewed. Pretty low impact factor though. Think I'll wait to see if this is independently verified.
  • ...They forgot to mention that when the gel detects American teeth it triggers an acidic reaction.

  • This sounds like the beginning version of the regrowth technology that the revered Robert A. Heinlein wrote about in The Door Into Summer.
    He was only talking about this in 1956.

  • Phase 1: Collect underpants. No, that's not it. Put this new chemical concoction in the drinking water.
    Phase 2: ?
    Phase 3: Profit!

    - This SIG was stolen by gnarly gnomes...

  • A few years ago a team from the U.K. based team of academics started a spin off company claiming something similar. Reminova [reminova.com]
  • They've been suppressing the shot that kills the damage causing bacteria for over two decades now, they'll suppress this as well. You can still find info of it on the Net. They still give you a shot of it if you're getting your mouth wired shut and it was in that gum they gave the Desert Storm Soldiers, but the masses are SOL.
  • So that's what that gel substance was they found on the moon.

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