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China Science

China Halts Work by Team on Gene-Edited Babies (apnews.com) 80

China's government ordered a halt Thursday to work by a medical team that claimed to have helped make the world's first gene-edited babies, as a group of leading scientists declared that it's still too soon to try to make permanent changes to DNA that can be inherited by future generations. AP reports: Chinese Vice Minister of Science and Technology Xu Nanping told state broadcaster CCTV that his ministry is strongly opposed to the efforts that reportedly produced twin girls born earlier this month. Xu called the team's actions illegal and unacceptable and said an investigation had been ordered, but made no mention of specific actions taken. Researcher He Jiankui claims to have altered the DNA of the twins to try to make them resistant to infection with the AIDS virus. Mainstream scientists have condemned the experiment, and universities and government groups are investigating. His experiment "crossed the line of morality and ethics adhered to by the academic community and was shocking and unacceptable," Xu said. A group of leading scientists gathered in Hong Kong this week for an international conference on gene editing, the ability to rewrite the code of life to try to correct or prevent diseases.
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China Halts Work by Team on Gene-Edited Babies

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  • I thought the lure of research in China was lack of oversight. If you can't conduct an ethically questionable scientific study there, what's the point?
    • by Luckyo ( 1726890 )

      Lack of oversight as long as you don't attract too much attention. The idiot at the head of the team decided to start giving interviews that made international news.

      Not sure if he was that stupid in things outside his field or realised that he's got too much publicity already and was trying to sell his project to party leadership before he was inevitably going to get shut down by party apparatus clamping down on his "actions that are damaging harmony in society".

    • You can do ethically questionable studies. You just cannot make the state look bad, lessen state control over the populace, or make the state weaker. If you publish a report that makes the state look bad internationally (we're making super-babies) you'll get smacked down.

    • How do you come to the idea that a totalitarian state has "lack of oversight"?

  • That's good to hear. I'm as concerned as anyone about the eugenics/GATTACA angle of this, but on a more immediate note, I think the potential off target effects are of ethical concern as well. If you're making a gene edited plant and you accidentally change something else that has a deleterious effect, who cares? Toss that plant and try again. In an animal model, if that happens and is causing undue problems, euthanizing the animal is an option.

    But in humans? You get one shot, and it better work exa
    • by tlhIngan ( 30335 )

      That's good to hear. I'm as concerned as anyone about the eugenics/GATTACA angle of this, but on a more immediate note, I think the potential off target effects are of ethical concern as well. If you're making a gene edited plant and you accidentally change something else that has a deleterious effect, who cares? Toss that plant and try again. In an animal model, if that happens and is causing undue problems, euthanizing the animal is an option.

      But in humans? You get one shot, and it better work exactly rig

      • by mentil ( 1748130 )

        They don't vaccinate babies either, to prove how strong their immune systems are, right? No? This is no different.

    • by Luckyo ( 1726890 )

      Once human genetic engineering become possible, a few hundred years in the future this kind of ethics will be the ethics held by those who will be known as "ancient ancestors that went extinct under competitive pressure with us".

      Which is why anyone with interest in continuation of their lineage will now be pouring resources into it.

      Most people living their comfortable lives in Western cities tend to forget something that everyone else remains acutely aware of. Evolution hasn't stopped. It's chugging on. And

      • Indeed. Look how common myopia in vision is now, whereas before it would have been a deadly flaw for our ancestors and thus there was a strong selective pressure against it. Even though we now we can wear glasses, (a prosthesis) or undergo surgery to correct for it, this should be unnecessary.

        This superstition and resistance to improve the human condition at the genetic level reminds me of how blood-letting was once seen as a practical medical cure. Yes every precaution and great consideration should be

        • by Luckyo ( 1726890 )

          Fun part about your analogy. World average IQ is in fact about 20 points higher than it was about a hundred years ago. Biggest suppressing element on IQ until modernity was childhood starvation.

          We still have the test cases in places like Malawi, where children were starving just a few decades ago. And now, they have a severe problem with competitiveness of work force against surrounding states, because those that were starving but survived as children have problems even at rudimentary tasks like doing house

          • Perhaps genetic engineering will be the second "removal of childhood starvation" level of civilizational advancement in our lifetimes.

            Interesting point, thank you.

            So far in my lifetime I've seen the rise of the internet and telecommunications. Now it is common for even gradeschool children to carry incredibly compact and powerful multi-function computers that can utilize the global data infrastructure for instantaneous communication. Further societal changes due to rapid onset of technological development in the next several decades doesn't seem all that far-fetched.

            It's actually a cause for a bit of hope.

        • imagine what our world might be like if the average IQ was just 20 points higher. That alone is worth some risks.
          From an ethical point of view: that only means, the psychopaths in business and government have a stronger grip on the less priviledged, those with less IQ.

          The ethical question is: do you want gene editing on perfect healthy embryos? Why? Is the edited gene transferred to off springs? What is better: if it is, or if it is not?

          Do you want to be dependent in future generations on elite doctors perf

          • From an ethical point of view: that only means, the psychopaths in business and government have a stronger grip on the less priviledged, those with less IQ.

            At first, sure that is a risk. What do we know about technologies as they mature and become subject to market pressures?

            The ethical question is: do you want gene editing on perfect healthy embryos? Why? Is the edited gene transferred to off springs? What is better: if it is, or if it is not?

            How that research itself is done ethically is the greater issue. Everything else amounts to putting the cart before the horse.

            However, the choice to remain captive to the biology of natural evolution is illogical, when we are no longer subject to normal evolutionary pressures. As products of evolution ourselves there must exist potential for improvement.

            For example, let's say that

            • As for IQ, if you don't believe that heightened intelligence allows for better capacity for learning,
              Yes, it does. But it does not mean the person in question is actually learning something.

              problem solving and critical thinking ability,
              As long as they have not learned 'problem solving', or 'critical thinking': no.

    • by MobyDisk ( 75490 )

      Toss that plant and try again.

      So long as the gene doesn't spreads to the nearby plants, which we now know can happen like Glyphosate resistance did.

      • When I say toss, I mean 'properly dispose of' as in autoclave. Not literally throw outside.

        But just FYI, glyphosate resistance didn't spread to nearby plants from the transgenic ones, it evolved in them. Selection pressure from continued spraying of glyphosate promoted the evolution of resistant weeds, which then had an advantage due to selection pressure, so they proliferated. I get what you're talking about, but that's not how it happened.
        • But just FYI, glyphosate resistance didn't spread to nearby plants from the transgenic ones, it evolved in them.
          How do you know that?

          We know since the 1930s that horizontal gene transfer between plants does exist.

          it evolved in them. Selection pressure from continued spraying of glyphosate promoted the evolution of resistant weeds
          How do you know that?

          Watched them evolving?

          I get what you're talking about, but that's not how it happened.
          Sorry, the likelihood that your parent is right, is probably a million tim

    • Researcher He Jiankui claims to have altered the DNA of the twins to try to make them resistant to infection with the AIDS virus.

      So how are they going to test this? Expose them to HIV?

      • by spth ( 5126797 )
        Expose some of their blood to HIV in a (sealed so no air gets in) petri dish.
        • Oh, yeah... IIRC, HIV lives partly in various types of white blood cells and their helpers - it is like malware hiding in your anti-virus software.
      • by mentil ( 1748130 )

        They were given a gene that's been studied for decades and is known to confer HIV resistance. If they're confirmed to have the gene, then experiment successful. A bigger question is if they're chimeras, with some of their cells having the gene and others not, in which case HIV could infect the cells that don't, thus leading to AIDS anyway.

  • You're only useful to the Glory of the Leader until you aren't.

  • Looks like China is going to have one less scientist in the near future.
  • Chinese gov, like most gov, has little to no ethics. They made this announcement but have no doubt allowed this to continue.
    This is no different than China's gov claiming that they were stopping large numbers of new coal plants and once their bad economy turned, they restarted the projects.
    THis group will go underground. literally and figuratively, to continue this work. They are learning how to make a body resist HiV. Later on, it will be other virus, such as a synthetic smallpox. Welcome to the soluti
    • by Luckyo ( 1726890 )

      The primary ethical principle of any state is state survival. It overrides everything else.

      That is because if you do not have survival, everything else is taken from you. This is not unique to humans, or even animals. This is a base principle of evolutionary process itself. And yes, that's one of the pathways to being the winners in the evolutionary race in the long run.

  • Is that a bun in the oven, or a salad in the crispr?
  • by sad_ ( 7868 )

    they may say one thing, and do another.
    as if china isn't massivly interested in developing this (well, probably not only china).

Every nonzero finite dimensional inner product space has an orthonormal basis. It makes sense, when you don't think about it.

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