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Medicine Science

Meet the Interstitium, the Largest Organ We Never Knew We Had (thedailybeast.com) 208

An anonymous reader quotes a report from The Daily Beast: A study published in Scientific Reports on Tuesday suggests that a previously unknown organ has been found in the human body. More astonishingly, the paper puts forth the idea that this new organ is the largest by volume among all 80 organs -- if what the researchers found is, in fact, an organ. The new organ, [pathologist Neil Theise] explained, was a thin layer of dense connective tissue throughout the body, sandwiched just under our skin and within the middle layer of every visceral organ. The organ also made up all the fascia, or the thin mesh of tissue separating every muscle and all the tissue around every vein and artery, from largest to smallest. What initially seemed to be a solid, dense, connective tissue layer was actually a complex network of fluid-filled cavities that are strong and flexible, yet so tiny and undiscerning that they escaped the attention of the brightest scientific minds for generations. In fact, Theise expanded, this "interstitium" could explain many of modern medicine's mysteries, often dismissed by the establishment as either silly or explainable by other phenomena. Take acupuncture, Theise said -- that energetic healing jolt may be traced to the interstitium. Or perhaps the interstitium acted as a "shock absorber," something that protected other organs and muscles in daily function. Also, the space is in direct communication with the lymphatic system as the origin of lymph fluid -- which means the interstitium's system of fluid-filled backroads could explain the metastasis of cancer cells and their quick spread beyond the limits of the organ in which the cancer started.
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Meet the Interstitium, the Largest Organ We Never Knew We Had

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  • by SuperKendall ( 25149 ) on Tuesday March 27, 2018 @10:42PM (#56338841)

    What initially seemed to be a solid, dense, connective tissue layer was actually a complex network of fluid-filled cavities that are strong and flexible

    I propose:

    The interstitium is the body's internet.

    After all, it's a very small layer of tubes that transmits through the entire body...

    • how does this relate to and compare with cars?
      • how does this relate to and compare with cars?

        When you are sick, it's like your interstitialian is a highway that's jammed with traffic.

        Alternately, you could say if the human being were a car, the interstiliarium is roughly equivalent to the rich Corinthian leather covering the seats and dash.

        • Since the bloodstream and lymphatic system also connect different tissues together in an already well demonstrated fluid transfer network of blood vessels, the transfer of cancerous cells from one organ to another would not seem to require explanation. And since acupuncture consistently fails double blind experiments, that would seem to be another "mystery of modern medicine" that would seem to be already explained, as a placebo effect.

          • Re: (Score:2, Interesting)

            You can not really test accupuncture with double blind studies, or how should the one poking you not know, kr know if he is really poking you? And how can you mot know if you get poked or not?
            There where attempts with double blind studies, where they used kind of electrodes to cause a fake sensation: turned out that electric stimulation had the same effect as a real needle. Hence we have since 30 years electronic and even laser based self accupuncture aparatus.
            And accupuncture works quite fine, no idea why

            • Because everything ELSE has evolved, and everything ELSE in our lives has been created based on solid scientific evidence, statistics, causality, and logic.
              With acupuncture people pulled an idea out of their hat and tried to shoehorn it under a microscope looking for evidence that it may have some logic or causality other than the placebo effect, selection bias and sampling errors etc.

            • by Anonymous Coward

              The problem is that acupuncture rarely has effects either. In every test it has shown to only be as effective as a placebo. Even in China it was recognized as quackery and outlawed.

            • by Antique Geekmeister ( 740220 ) on Wednesday March 28, 2018 @06:13AM (#56339923)

              > You can not really test acupuncture with double blind studies, or how should the one poking you not know, kr know if he is really poking you?

              It's testable by "poking" somewhere else than where the practitioner would plan. As I understand it, Different practitioners have different patterns for what disorders or issues are treated by different acupuncture points. If there is no verifiable association between the acupuncture points and the disorders, if it doesn't matter which acupuncture points are used, then that indicates it's a placebo effect.

              • Double-blind means that the person administering the treatment or placebo does not know the difference (in addition to the patient). So if you are being poked in a place other than where the practitioner would plan, then you might have a problem being able to do a double-blind study. In general, if a procedure or theory is not falsifiable (testable) then its probably a sham.

                • by abies ( 607076 )

                  Double-blind means that the person administering the treatment or placebo does not know the difference (in addition to the patient).

                  Double-blind study means that neither patient or person _compiling the results_ knows if this was placebo or real treatment. In many cases outside of simple medicine switch, person executing the experiment (as it goes outside of just medical subjects) is very well aware if it is real or not, he just labels it in secret which will get revealed after all the single measurements and compilations on A/B (rather than placebo/real) are finished.

              • As I understand it, Different practitioners have different patterns for what disorders or issues are treated by different acupuncture points.
                Actually they don't have.

                If there is no verifiable association between the acupuncture points and the disorders, if it doesn't matter which acupuncture points are used, then that indicates it's a placebo effect.
                Yes, but first of all: that is not a double blind study :D
                Secondly: there is no such study, but if you know one, a link would be interesting. To see what they a

                • >> As I understand it, Different practitioners have different patterns for what disorders or issues are treated by different acupuncture points.
                  > Actually they don't have.

                  There is, as best I can tell, no master map used by all or even most practitioners. The Google images for acupressure points show this: The variety of needle locations for ear, foot, or hand to treat the same disorders provides a good sense of the lack of consistency among these practitioners.

                  https://www.google.com/search?... [google.com]

                  I've

            • by Tom ( 822 ) on Wednesday March 28, 2018 @06:14AM (#56339929) Homepage Journal

              And accupuncture works quite fine, no idea why americans are so anti to thousands of years old proven working technologies, that basically cost nothing und rarely have side effects.

              Replace "americans" with "rational people" and you will get an answer.

              For example, you will learn that the whole
              "thousands of years" is bullshit [sciencebasedmedicine.org].

              Oops.

              • Unfortunately the famous Oetzi has most interesting acupuncture points tatooed on his body, he is about 5,000 years dead.

                The early emperors of China did mass studies with POWs ... killed a few 10,000 people in that process in the attempt to find deep in the body acupuncture points on the "Facia skin" around organs.

                That is all well documented and can still be read in modern libraries, in China. Unfortunately you have to be able to read "old school" Chinese characters or trust your translator.

                Oops!!

                • Unfortunately the famous Oetzi has most interesting acupuncture points tatooed on his body,

                  Oetzi had tattoos. You need to show that they are acupuncture points. I have friends with similar designs that have nothing to do with acupuncture and everything to do with following body features.

                  That is all well documented ... Unfortunately you have to ... trust your translator.

                  Joseph Smith of the Mormons used a similar argument.

                  Oops!!

                  TL:DR "I have this really compelling evidence that I can't show you"

                  • I don't have to prove anything.

                    We have thousand years old mummies, with tattos at/around acupuncture points.

                    If you want to prove that it has nothing to to do with acupuncure, you are my guest.

                    Ever heard about Occams Razor?

                    • by Tom ( 822 )

                      If you want to prove that it has nothing to to do with acupuncure, you are my guest.

                      Easy.

                      Take a random sample of people and drive them down the same country road. At the end, ask them individually for the landmarks along the way that they remember.

                      There is a good chance that you will have a considerable overlap, wouldn't you agree?

                      Same with the human body. If you are looking for interesting places to prick, or to paint, you will likely end up with similar locations. Especially with a large sample.

                      Ever heard about Occams Razor?

                      Yes, and now you have, too.

                • by Tom ( 822 )

                  I checked up on Oetzi since my ancient Chinese is a bit rusty.

                  The acupuncture hypothesis is that exactly, and it is brought forth by acupuncture people (main claim "these tattoos are at the locations which I would prick today"). Even they admit that a third or so of the points don't make sense to them.

                  Fact is that we don't know. People who believe in acupuncture have thrown up a theory that these tattoos are related to acupuncture.

            • And accupuncture works quite fine, no idea why americans are so anti to thousands of years old proven working technologies, that basically cost nothing und rarely have side effects.

              So, eating ground tiger penis is better than viagra?

            • Re: (Score:2, Informative)

              by Anonymous Coward

              You can not really test accupuncture with double blind studies, or how should the one poking you not know, kr know if he is really poking you? And how can you mot know if you get poked or not?
              There where attempts with double blind studies, where they used kind of electrodes to cause a fake sensation: turned out that electric stimulation had the same effect as a real needle. Hence we have since 30 years electronic and even laser based self accupuncture aparatus.
              And accupuncture works quite fine, no idea why americans are so anti to thousands of years old proven working technologies, that basically cost nothing und rarely have side effects.

              They've proven through experiment that acupuncture is worthless. It doesn't matter at all whether the acupuncturist uses the "correct" points or if they make up locations to stick in the needle, or whether they pierce the skin or just poke you with a pointy tool.

              The double blind is that the person recording the experiment and tallying results, and the patient, doesn't know if the "professional" used the right point or not. Or if the skin was pierced. They just confirm the report from the patient on their sy

            • or how should the one poking you not know, kr know if he is really poking you? And how can you mot know if you get poked or not?

              Easy.
              Leave the poking to the assistant who doesn't know jack shit about where he/she SHOULD poke - just how to stick the needle into a predesignated spot marked on a drawing.
              Compare results of "real acupuncture" to "randomly poking with needles" and "deliberately wrong acupuncture" - giving patients "cures" which would promote their illness.
              If it works - it'll show.

              As for the subject not knowing... there are several ways.
              Subject could be just poked, without actually being stuck with a needle.
              Subject could b

              • Subject could be just poked, without actually being stuck with a needle.
                Does not really work, as poking is enough in most cases.

                Subject could be given a local or general anesthetic.
                That is interesting ... but I guess it only would work if the subject does not notice the poke.

                Subject could be asleep.
                If you do not wake up from that, I guess you have a problem that requires more hard core treatment.

                Subject could have severed nerves.
                Subject could have spinal injury.
                Subject could be in a coma.

                That is actually do

    • by smithmc ( 451373 )

      I propose:

      The interstitium is the body's internet.

      After all, it's a very small layer of tubes that transmits through the entire body...

      ...and it's mostly used for porn?

  • The Value of Walking (Score:5, Interesting)

    by rtb61 ( 674572 ) on Tuesday March 27, 2018 @10:46PM (#56338855) Homepage

    The Interstitium would help to explain the value of walking, shifting around the https://en.wikipedia.org/wiki/... [wikipedia.org], providing background circulation of fluids. It would help to explain why people find comfort in a peace amble, especially those suffering from mental conditions https://en.wikipedia.org/wiki/... [wikipedia.org] could be a form of internalised therapy, to make up for stress affecting other fluid flows. Got nothing better to do, walk around you home to keep circulation going, whilst waiting for water to boil for a cuppa, or while roasting a steak, just a peaceful amble about to home to stimulate Interstitium fluid flows, the expansive and contracts of major muscle groups would certainly move that fluid around the body.

  • by Ungrounded Lightning ( 62228 ) on Tuesday March 27, 2018 @10:59PM (#56338873) Journal

    Now that this structure of what appears to be the container for the extracellular fluid and a major shock absorber for tissues has been identified, it will be interesting to see what disease processes might be the result of degradation of its function.

    I'd expect examination of breakdowns in this system to result in the causes of several diseases, currently dismissed as psychosomatic or as real but mysteries, to be identified.

    I'd also expect that the structure might degrade in old age, and that this might be another source of age-related problems.

  • by Babel-17 ( 1087541 ) on Tuesday March 27, 2018 @11:06PM (#56338889)
    I grew up on those "I am Joe's ..." articles as featured in Readers Digest. :)
    • by kalpol ( 714519 )
      I am Jack's complete lack of surprise... That was a fun moment in Fight Club when I recognized the references to the Reader's Digest articles.
  • So weâ(TM)re basically little air bags all surrounded by bubble wrap. Once we become a space faring civilizations, aliens will find us, cut us open, and wonder why someone shipped empty parcels all over the universe.

    • So weâ(TM)re basically little air bags all surrounded by bubble wrap..

      From which some people gain inner peace by popping bits of the bubble wrap with pins. THIS is what explains acupuncture.

  • Old news ... (Score:2, Interesting)

    Everyone who practices Chi Gong or other internal arts knows that ... since millennia.

    • Re: (Score:2, Insightful)

      by Anonymous Coward

      Qi Gong is right up there with homeopathy, anti-vaccination, and is often literal bedfellows with traditional medicine made up of ground endangered species penises to make the Qi Gong practitioners more virile.

      • Let's be charitable. Acupuncture, properly done, has few or no adverse effects. The only way it's likely to be harmful is if someone relies on it instead of getting effective medical treatment. You can't say nearly the same about anti-vaxx movements.

    • Everyone who practices Chi Gong or other internal arts knows that ... since millennia.

      Oh do they now? Are you seriously claiming that QiGong [wikipedia.org] is anything more than a mild form of exercise? In spite of the fact that there is little evidence [wikipedia.org] to support its efficacy for any specific health benefit.

      You know what they call alternative medicine that is shown to actually work? Medicine.

      • Yes,
        I have thousands of cases of evidence that QiGong is a very healthy thing.
        And those who practice know about "how it works", the "modern word" is Facia.
        Assuming that QiGong is a mild exercise is idiotic. It is a martial art and healing system.
        E.g. you might look at this: https://www.youtube.com/watch?... [youtube.com] probably you find better videos, but I'm to lazy to do your work for you.

        Medicine helps in situations where medicine helps ... e.g. a common cold. It does not really help when you have a slipped disc. Qi

        • I have thousands of cases of evidence that QiGong is a very healthy thing.

          No you do not. You certainly do not have an proper studies of such nonsense.

          Assuming that QiGong is a mild exercise is idiotic. It is a martial art and healing system.

          It is neither a martial art nor is there any evidence that it is a healing system. There is nothing martial about it. I've been involved in various martial arts my whole life and QuGong is exactly the sort of fraudlent crap that guilible people like yourself get sold. I'm betting you think tai chi is a fighting art too. Most of the so called martial arts are really stylized dance classes with a bit of mythology tacked on. Fun,

          • Lease send me a link that shows that someone studied if QiGong is a healing system.
            I really doubt any westerner ever cared to make a study about it.

            That it is a martial art is obviously without doubt. If you don't know that, you should probably realy consider to stop posting about topics you have no clue about?

            Your MMA reference spoiled it completely, there is no martial art called MMA. MMA is a entertaining competitive fighting event where people who do diverent Martial arts (the second M) can be Mixed (th

  • Nerds, please explain how that is an organ.
  • Your doctor doesn't want you to know about it.

  • Take acupuncture, Theise said -- that energetic healing jolt may be traced to the interstitium

    there is no "healing jolt" (shame acupuncture works as well as acupuncture - both can be explained with placebo and similar effects - there is demonstrably no healing compared to control group, just in some cases lesser perception of pain).

  • Common definitions of an organ, Webster:
    > a. differentiated structure (such as a heart, kidney, leaf, or stem) consisting of cells and tissues and performing some specific function in an organism.
    > b. bodily parts performing a function or cooperating in an activity the eyes and related structures that make up the visual organs.

    Wikipedia:
    > Organs are collections of tissues with a similar function.

    Britannica:
    > a group of tissues in a living organism that have been adapted to perform a specific fun

    • by dafradu ( 868234 )

      FTA:
      "The characteristic histological features of this bile duct submucosa structure (spaces filled with fluid and with collagen bundles lined asymmetrically by flat cells) are readily visualized in other tissues."

      This fits all definitions you posted, it is a a structure or group of tissues with some particular function that is part of the human organism. It is as much as an organ as the skin, it fits the same definition.

  • Can you really just rename the lymphatic system, declare it is a new organ, associate it with woo and pat yourself on the back? In that case, I've discovered a new organ I'd like to call the sanguitium... it explains the mysterious medical benefit of bloodletting and balancing the humors.

Any sufficiently advanced technology is indistinguishable from magic. -- Arthur C. Clarke

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