Potentially Deadly Drug Interactions Found Mining FDA Complaint Bin (arstechnica.com) 55
Thousands of people are sent to the hospital each year from adverse drug-drug interactions that are difficult to predict and even trickier to track. To get around the problem, a team of researchers (working with the journalists at The Chicago Tribune) created a computer model to create side-effect profiles for prescription drugs. Then, they mined a massive database of drug-reaction complaints sent to the Food and Drug Administration, as well as 380,000 electronic health records. The results of the analysis so far suggest that four drug combinations "including the combination of the common antibiotic, ceftriaxone, with the over-the-counter heartburn medication, Prevacid (lansoprazole) may cause a potentially fatal heart rhythm.
AARRGGH (Score:4, Funny)
A link (Score:2)
to an article might be useful
Re:A link (Score:5, Informative)
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http://arstechnica.com/science... [arstechnica.com]
"The other problematic drug combinations that the data flagged as possibly producing the same heart problem are: cefazolin, an antibiotic, and meperidine, a pain medicine; meperidine and vancomycin, another antibiotic; and metoprolol, a blood pressure medication, and fosphenytoin, a seizure medication."
Son of a Bit@# /. might of saved my life, at the least added to it; till this article I took Metoprolol.
Re: A link (Score:1)
Dude, don't stop the metoprolol... just avoid combining it with its evil twin. If you rely on /. for medical advice, all I can say is Darwin.
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Dude, don't stop the metoprolol... just avoid combining it with its evil twin. If you rely on /. for medical advice, all I can say is Darwin.
If one follows the links further in, it shows Metoprolol alone increases the QT level in 13% of the patients, 22% when comboded.
http://www.chicagotribune.com/... [chicagotribune.com]
A lengthened QT interval is a marker for the potential of ventricular tachyarrhythmias like torsades de pointes and a risk factor for sudden death.
https://en.wikipedia.org/wiki/... [wikipedia.org]
Metoprolol isn't manufactured as a QT adjuster https://en.wikipedia.org/wiki/... [wikipedia.org] in fact advised against it's use for that condition http://circep.ahajournals.org/... [ahajournals.org] (ve
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There are a fuck ton of drugs that increase the QT interval. To stop taking metoprolol based off of this article is beyond fucking retarded. Metoprolol is a very good drug. Speak with your cardiologist before being a fucking retard. -dr
Ah heck, I have an appt this week it's been scheduled for awhile now, even used the website the Hospital set up to send a message to my Dr. Give me a break, you don't know of the secondaries.
As for the "There are a fuck ton of drugs that increase the QT interval."
I would think so after that article, it's that sudden death that has my attention. And yes I'm aware that in 2013 Metoprolol was the 19th most prescribed drug in the US.
Linky? (Score:2)
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Look, we warned you when you arrived...
Slashdotters are a bunch of cranky old farts who can't handle anything moving around on them, even if it looks exactly the same and only moved 15 pixels to the left. I expect there's at least one of us who reads the site on a VT100.
Now that I said that, I realize I have a brand-new VT220 in a box in my closet, and I have a Raspberry Pi that needs a new job... Slashdotters are a bunch of mad engineers [cowbirdsinlove.com]...
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Give the man some rope! - Some Russian guy... (Score:2)
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"The results suggest that four common drug combinations may cause a potentially fatal heart rhythm." ... Um, which are? May be important in here.
I wouldn't get your panties in a twist just yet. Even though the methodology is interesting there is ** NO ** statistical analysis of the data so I'm presuming that non exists and this is one of those many, many "associative" studies that don't pan out in practice. To their credit, they try to correlate the drugs with some sort of plausible biochemical pathway but without any sort of kinetic data, it is impossible to determine if these things actually do happen and if they do, to what frequency.
The combin
Can I be a Slashdot editor now? (Score:2)
TFA: http://www.chicagotribune.com/... [chicagotribune.com]
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Link to ARS Article (courtesy of Google) (Score:1)
http://arstechnica.com/science/2016/02/potentially-deadly-drug-interactions-found-mining-fda-complaint-bin/
FDA Complaint (Score:3)
Dear FDA,
I have been prescribed this combination of drugs which I believe to be .... [Eeep! Aaack! Gurgle ........ Thud!]
Re: FDA Complaint (Score:2)
When questioned... (Score:2)
...the interactions claimed they thought some of the complaints might have been for them.
Use the (real) source, Dude (Score:1)
The original scientific paper can be found at http://link.springer.com/artic... [springer.com]
and the supplementary material can be found at http://static-content.springer... [springer.com]