New Treatment Stops Type II Diabetes 253
multicsfan writes Researchers have found that an injection of protein FGF1 stops weight induced diabetes in mice, with no apparent side effects. However, the cure only lasts 2 days at a time. Future research and human trials are needed to better understand and create a working drug. From the story: "The team found that sustained treatment with the protein doesn't merely keep blood sugar under control, but also reverses insulin insensitivity, the underlying physiological cause of diabetes. Equally exciting, the newly developed treatment doesn't result in side effects common to most current diabetes treatments."
There's another treatment that stops most T2 (Score:5, Informative)
It's called eating well, exercising and losing a significant amount of weight.
I know, I came very very close to having it. Break the sugar addiction, quadruple your vegetable intake, vastly reduce your sugar / heavy foods intake and do a little, tiny bit of basic light exercise.
In a couple of years, guess what,...?
Re:There's another treatment that stops most T2 (Score:5, Informative)
Sorry but what you say here is a load of crap. Actually no I'm not sorry, it's just a load of crap said by somebody who doesn't know shit about the condition and just wants to find any old reason to attack their eating habits.
Insulin resistance doesn't magically get cured by eating right and exercising. Yes, you can much better manage the symptoms that way, but ultimately they don't go away. At the end of the day you still have to watch your glycemic load, which doesn't necessarily come from sugary foods. In fact several vegetables can cause hyperglycemia in diabetics. Pretty much the only way to avoid that in most cases is to eat so little that you aren't meeting your daily caloric needs, which means you'd need to starve yourself to death in order to avoid taking insulin.
I don't have diabetes, but I've been way overweight (at one point I weighed 290 pounds) and all of the blood tests I took indicated I was nowhere near being diabetic even at THAT time. Yet many other people who have a much lower BMI than I do even right now (I currently weigh 215) and are even younger than I am have type 2 diabetes. The added weight just makes it that much harder for your body to meet its own insulin needs, so losing weight can help manage the symptoms (and in certain cases eliminate them until your later years in life,) but it will never cure it.
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Re:There's another treatment that stops most T2 (Score:4, Interesting)
Surprisingly, I also have very low blood cholesterol levels -- many physically fit people with healthy eating habits have several times higher levels.
Yeah; your cholesterol levels are controlled by your liver. GGP comes off to me as being a dietary fanatic, the likes of which I've seen all too often, and they're kind of annoying because they play armchair general about what everybody shall and shall not eat, meanwhile their knowledge of biology and chemistry tends to be really bad, just like GGP's appears to be (or at least, a very VERY bad understanding of what diabetes is.) I remember one dietary fanatic telling me how his cholesterol was high, so he decided to become a vegetarian. I don't know whether or not he solved that problem, but if he did the vegetarian diet had very little to do with it, but he's just going on being smug anyways. (In fact the Harvard Study vegetarians frequently cite about read meat being "bad" doesn't actually suggest this, instead it shows a link between people with uncontrolled diets and various diseases...but interestingly it also suggests a link between vegetarian diets and high cholesterol, which they never acknowledge.)
In fact, in recent years we've found that dietary cholesterol has very little impact on blood cholesterol, and may even have no impact at all. What we have found to influence it is saturated fats; less of them will reduce your blood cholesterol. More unsaturated fats will also reduce it (i.e. omega-3.) Exercise also effects it. However dietary changes and exercise have been only found to reduce blood cholesterol by about 30% in the best case scenarios. Beyond that, statin therapy is very effective. People who claim to be "naturalists" (ironically none of them can seem to even agree what the word "natural" means) often tell me how I shouldn't be taking these pills, but I take lovastatin and as a result my cholesterol levels are well within normal range whereas before that and my triglycerides were really high (typically tryglicerides are high when you take in too many calories, which given I am losing weight rather quickly rather quickly, that simply can't be the case; the liver doing something it isn't supposed to be doing however would explain it perfectly.) No side effects either.
GGP types also tend to be those anti-GMO, pro organic extremists, which are even more annoying because at the end of the day there is zero conclusive evidence against GMO, and zero evidence that suggests organic is in any way better than anything else (but it certainly costs more!)
Anywho, being overweight in general isn't a good thing, but if you don't have hypertension and some of the other issues that go along with it, you aren't really in danger of anything bad happening any time soon. The main reason I had to lose weight was due to reduced renal function, which was caused by another unrelated problem related to the immune system (specifically, IGAn, which nobody has ever been able to identify the cause of, and it isn't any more prevalent in overweight people than anybody else.) However reduced weight means reduced body mass, which means reduced need for filtration.
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Careful here, a low cholesterol level is associated with high CHD risk. The ~15% of people with the lowest total cholesterol (165 mg / L IIRC) account for ~40% of the heart attack deaths, that's quite an over-representation.
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Insulin resistance doesn't magically get cured by eating right and exercising.
That's true, eating right and exercising prevent you from getting it in the first place. But once you've gotten it, they can't undo it, it's too late by then.
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Well that's certainly not true. You can eat plenty of meat, eggs, spinach, broccoli, olive oil and much much more.
Re:There's another treatment that stops most T2 (Score:4, Interesting)
No, that's not the problem. Only a half-wit conspiracy theorist dumbass would think they aren't trying to find a cure. The fact that they got here alone speaks volumes about just how badly they want one. What they've discovered is groundbreaking. They didn't choose for diabetes to exist. They also didn't choose for this treatment to only last two days, rather that's just an unfortunate downside of it. If you think it's so damned easy to find a cure, go publish your own damn paper.
Not everybody is involved in a conspiracy to deprive you of your wallet. The fact that you see it that way is entirely your choice to do so, and is probably the reason you feel like shit every day and think everybody is out to make your life suck. If you really hate civilization that bad, go live in a tree, shit in the woods, get a tropical disease, and see just how much better life is without all of the evil drug companies ruining it for you.
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Only a half-wit conspiracy theorist dumbass would think they aren't trying to find a cure.
I think this is one case where conspiracy theory is basically the truth. Big pharma has created one of the most systematic systems of scientific fraud on the planet - running multiple studies and carefully cherry picking only those that happen to produce positive results to promote their new drugs, over the old ones with expired patents being just one of the tricks they use. If you want to see an excellent discussion of it from a statistical epidemiologist, read Bad Pharma [amazon.co.uk] by Ben Goldacre.
In some cases, the
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Wouldn't it be easier and more profitable for them to sell the one-time cure for the same price as the lifetime treatment?
Re:There's another treatment that stops most T2 (Score:4, Insightful)
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A rumor without any reasonable evidence to support it.
Re:There's another treatment that stops most T2 (Score:5, Informative)
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I'm pretty fit myself, not particularly overweight, an avid motorcyclist (light exercise for many hours at a time) and I'm good with the foods. I'm in my 60's, too. I have Type II. The symptoms can be managed, but I don't particularly enjoy the method. And shaming people for conditions they can't help is not what kind people do.
If they come up with something better than Metaformin, I'm in.
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Thank you. I stopped just saying "Fuck you" to the idiots who want to bash diabetics, because it seems to turn the few who aren't just looking to boost their own egos off to learning, and I want to reach every one that can be reached, but I'm in fundamental agreement. I didn't start having symptoms until my early forties, and am nearly 60 now, but I think I understand (see my post above if you want).
You see something from someone on the internet who doesn't have the genes
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Fuck him too. I weigh 285. I can walk a 6:25 1/4 mile. I have 11% that probably isn't body fat. And I have been a Type II diabetic probably for the last 9 years. Fuck him for shaming people with a disorder period, regardless of the type.
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I'm 45 yrs old, run 15-30 miles per week, eat as diabetics should, etc. I'm 6'0" and just over 175lbs now. I've been diabetic for 10 years. I'm not currently on any medication, but probably will be in the next year or so. My numbers keep creeping up.
There is a subset of people who just think that anything wrong with somebody is their own fault. Small people with limited understandings. And it's amazing the da
Re:There's another treatment that stops most T2 (Score:5, Informative)
Actually, it prevents MOST instances of Type II BEFORE you end up with a broken endocrine system. Once you pass a certain threshold, however, you're broken, and diet and exercise can help you not need meds, but you're STILL a Type II Diabetic.
This appears to undo part of the damage done- which is a step in the right direction.
Re:There's another treatment that stops most T2 (Score:4, Informative)
Nope. [nih.gov]
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That's a good approach for many. However, for the 25% of men who suffer from low testosterone- it's not as effective. Just like women can get gestational diabetes, men can get diabetes from other causes (including low T) and all the dieting and vegetabling in the world won't help.
Likewise, if you come from certain racial backgrounds- the diet approach isn't nearly as effective.
However- a healthy diet is good for other things (heart disease for one- subject to the same limitations of course).
Healthy food d
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That's actually not a cure. It's a treatment, and it works, but it's not a cure.
I started doing that about 7 years ago. I was never obese, but I was overweight and I ate a lot (and I mean a LOT) of crap.
So, I stopped eating crap, and started getting a lot more exercise. I didn't lose any weight but I lost a whole lot of fat. My A1C last check was 6.1, and my glucose levels tend to be normal... but.
If I go eat a pizza right now, my blood sugar will still spike. It probably won't go a LOT above 200, but it wi
Re:There's another treatment that stops most T2 (Score:4, Interesting)
It's called eating well, exercising and losing a significant amount of weight.
I know, I came very very close to having it. Break the sugar addiction, quadruple your vegetable intake, vastly reduce your sugar / heavy foods intake and do a little, tiny bit of basic light exercise.
In a couple of years, guess what,...?
Watch this: https://www.ted.com/talks/pete... [ted.com]
Get some compassion.
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In a couple of years, guess what,...?
What?????
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You individually, great, pat yourself on the back, but you're not most people. We know empirically that most overweight people will stay overweight, and d
Re:There's another treatment that stops most T2 (Score:5, Insightful)
Bullshit, I've been doing it for 2 years now and healthy food is fine, it tastes like food, not random chemicals and slop.
It's actually not that difficult to cook something healthy and quickly in a short amount of time once you actually put the effort in for a couple of months, a quick and simple food routine is great.
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Well, I have a problem with how food feels in my mouth and going down, the texture of it matters a lot. The more consistent, predictable, processed feel the food has the more likely I am able to eat it, but alas, healthy food tends to be rough, tangy, contain all sorts of surprises and all that and I just can't stomach it. I just don't know how to make healthy food that tastes *and* feels good.
Indeed you do. One you should really genuinely seek professional help for. Because you have by your description got a food phobia. Quite common in kids with parents who never made them sit down and finish their dinner, including the nutritious yucky bits, or parents who didn't do much cooking.
Trust me.. your concept of what tastes good or bad is not what it should be. But it can be fixed. Not by forcing yourself to eat normal food, or refusing to eat with others. It's a complicated, and often deeply hidden
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I think you missed out on the overall long term feeling you have that induces you to take the pills. Which is a permanent feeling. It also then sucks to feel dependent on said pills to feel at all well.
You're kidding about the pills, right? You don't consider your body just a big sack of chemicals used as the life support system for your brain, do you? Or is this a futile argument for me to even make?
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No, but it does mean that some of you who would have gotten cancer, don't.
As the original poster suggests, it's all about learned response to food.
My daughter likes processed crap as much as any 10 year old, but she loves home cooked food with plenty of veggies. Last Friday she was literally using both hands to cram the broccoli into her face (it was tempura broccoli, deep fried but basically nearly raw with a very thin coating of batter on a large piece of broccoli).
She was brought up with a wide variety o
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Eating vegetables prevents cancers? Or not eating vegetables causes cancer?
Is this information being withheld from us by some sort of anti-vegetable cabal? Wouldn't it be easier for the corn producers to let us learn this and just sell us raw corn instead of corn syrup?
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"Works for me. Close ticket"
That's not how science works.
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Works for most people, do some reading and get back to me.
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Here.
Have a cookie.
what works for you may not work for others, as others may have reasons or other issues that preclude what works for you.
shortly, you cannot speak to everyones situation and to do so is extreme arrogance.
thus, this potential treatment is a huge boon to those people.
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What gets me is liking chocolate too much. I lose all self control around a box of truffles. The only safe thing is to get a bag of dark chocolate I really don't like too much and limit myself to a few pieces a day as a treat.
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Eating does involve a bit more than just taste however, and is a problematic issue I've had to deal with most of my life.
I should admit up front that I have the opposite problem as to the article being discussed.
I've had no sense of smell since age 3-4, and so there is a significant class of foods I simply can't taste at all. The texture of the food determines completely my enjoyment of eating it and even my ability to eat it.
For me a steak tastes about like cardboard, and the less well done it is cooked t
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Too bad healthy food tastes and/or feels like shit and excercise is frustrating, wholly unpleasant and time-consuming :/
Yet those of use who exercise and eat healthy seem to lead a happier life. With so much frustration and time wasting, it's a strange thing isn't it?
Maybe you should give it a go some day. You might end up liking your veggies and feeling good exercising...
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What I meant was, you can train yourself to like healthy foods, to the point of craving them. Me, just eating one small burger from McDonald's makes me sick now.
As for exercising, it make you feel good. It really does. It's a real buzz after an mere half hour of cycling or swimming.
And then, in the grand scheme of things, when your health is good, you generally feel good too.
Staying healthy makes you feel good, but it does so in the medium to long run, and it takes a bit of effort to get going. Chocolate pr
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I would need to solve the food texture
Well, the process of "fixing food texture" is probably mankinds oldest cultural achievement: its called cooking. Take some cookery courses - not some diet-crap, but serious gourmet-cooking. If it does not taste good, it cannot be healty.
I do not get any sort of "buzz" after excercise, I do not feel good about it, it just makes me cranky.
I guess this is quite normal - especially endurance training. If diabetes T2 is an issue, than high intensity strenght training https: [wikipedia.org]
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I agree that pounding a treadmill in a gym is boring as hell, but put me on a bike with some countryside around and I'm happy as a pig in a Jewish vegan festival.
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that's because enforced exercise in a special purpose exercise room is unnatural. Try cycling or walking to and from your work, and try standing up at work for a significant portion of the day.
I have done all of the above. One job I had was with a company whose policy was "if you have time to sit down, you're slacking". The nearest bus stop is about 1 mile from my home. And in summer, if I don't mow the lawn every 15 minutes or so, children and small animals may disappear.
Sorry. No endorphin rushes came my way. All I ever get is hot, uncomfortable, sore and annoyed.
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All I ever get is hot, uncomfortable, sore and annoyed.
I think that's true of everyone it's just that the morning gym types get pleasure from rubbing others noses in it. The "I cycled to work this morning" and "I did X in the gym this morning" folk seem to spend all day with lower productivity and tend to be more prone to moodiness. The staff I work with were better before their health kick. I'd prefer they waited until after work, makes my job more pleasant.
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Spot on. People ignore selection bias too often.
Or maybe.... I am just more aware of people who ignore selection bias!
Re:There's another treatment that stops most T2 (Score:5, Interesting)
Oh so wrong. Healthy food is also fabulously tasty. Too bad most people have no idea what food actually is healthy and which ain't so much.
Through my college years of pizza, pasta, candy, couscous, cereal muesli and homemade fruit juices I ended up obese and prediabetic in 2007. I lost the extra weight and reversed the diabetic symptoms (fasting glycemia and Hb1ac back to normal) on zero exercise and a diet of roasted fatty duck filets (with the skin braised crispy), salmon sashimi, lamb/veal casserole, chicken massala and lots of greens bathing in molten butter.
There is a big personal investment required though: you must learn to cook.
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Oh so wrong. Healthy food is also fabulously tasty. Too bad most people have no idea what food actually is healthy and which ain't so much.
Through my college years of pizza, pasta, candy, couscous, cereal muesli and homemade fruit juices I ended up obese and prediabetic in 2007. I lost the extra weight and reversed the diabetic symptoms (fasting glycemia and Hb1ac back to normal) on zero exercise and a diet of roasted fatty duck filets (with the skin braised crispy), salmon sashimi, lamb/veal casserole, chicken massala and lots of greens bathing in molten butter.
There is a big personal investment required though: you must learn to cook.
One of my favorite snacks is raw vegetables and hummus. Hummus isn't perfect, but I use olive oil, and chickpeas are favorite among diabetics due to their high fiber and low glycemic index. No cooking required for this one.
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The current trend of declaring fat to be the boogeyman to be avoided at all costs is causing a lot of this. The result is packaged foods with no fat and a load of sugar and pepper to try to give it some sort of taste. Naturally the sugar is a blend of separate ingredients so they don't have to list it first on the ingredients.
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Healthy food probably tastes horrible to you as you're not used to it. That's one of the problems with too many sweeteners (sugar and artificial ones) and salt being pumped into everyday food. If you can wean yourself off of the processed food bandwagon, your taste buds will return to a more normal state and ordinary food will begin to taste delicious.
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"Exercise should be fun - you just need to find a sport/activity that you enjoy enough so that it doesn't seem like a chore."
Exercise that has a reason is good. Walking or cycling as a form of transportation (like to/from work or the shops) is a good example, plus you save on CO2 emmissions and cost of gasoline. Of course cycling may not be possible in winter if you live in a northern state, but walking should be. Of course if you live too far away from your work maybe you could just walk part wayu and use
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It can also be a lot of fun to just walk/cycle/run somewhere just because you fancy it rather than because you need to go there. I think it increases the enjoyment you get from exercise if sometimes you do it "just because you can".
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Try eating an apple first thing in the morning. The first thing you eat after getting up.
Then try eating an apple after having a slice of bread. You'll notice a difference.
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I agree completely that exercise for the sake of exercise sucks. The trick to happiness in exercise to find something you can enjoy for it's own sake. Physical activity is great for lots of reasons, but weight loss isn't one of them. If
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Fresh fruits taste like shit?
Yes.
steamed veggies.
Yes.
Multigrain bread
Yes.
colby jack cheese, lettuce and tomato tastes like shit? Oats stirred with sliced banana, raisins, greek yogurt and vanilla for breakfast tastes like shit?
Yes to all of those.
Translation: If it's not shit it tastes like shit.
Re:There's another treatment that stops most T2 (Score:5, Interesting)
Probably not. Both me and my ex are Type 2. I can't afford to get even 20 lbs. over weight (I'm 6'1", For me, I should weigh at least 180 - that's show off the six pack range, but even with measured bodyfat at less than, say, 14%, I still have to use some oral meds if I get only 20 lbs. over what looks to be about ideal). For her, at only 5' 6", she could probably get above 220 before she would need to use insulin or see progress in retinopathy - she has some initial traces, but the progression has been totally stalled for nearly 10 years now. However, she has to stay below 180 lbs. or she has peripheral neuropathy symptoms (that's in the feet, where it usually starts. Under 165, she stops having those symptoms, plus even needing Metformin, and so she's trying to stay there. She has about the usual cushion for Type 2, I have almost none at all. For typical Type 2's, managing the disease well enough to beat neuropathy is also plenty to beat retinopathy. For atypical ones such as myself, who knows, but what AbRASION wrote is generally good advice.
However, it's generally tougher than what he (?) wrote - more like 30 minutes + of just plain running 3x a week, PLUS some weights and wierd stuff like climbing walls, standing jumps for elevation and such, so the gym sessions usually go to a full hour, and weekend hiking, swimming, cross-training if either of us gains even five pounds, and often if not. We both run in 10 K's not just 5's,,and have managed a half marathon in the last 2 years. She leg presses 550 lbs to my 440, I'm benching 265 to her 110. If that's light exercise to someone, their dad's name was Jor El.
Quadrupliing your complex carbs? Well double them at least, and cut the simpler starches nearly as much as the sugars. "Vastly reduce your sugar intake" is also accurate, as in NO HFCS, NO sweetened soft drinks, Stevia is a lifesaver, a cookie? - is it my birthday? We had to memorize, and check for changes frequently, which peanut butters or canned soups have how much added sugar - there's added sugar or HFCS in a whole lot of products that people don't usually expect. Who would think that some brands of Smoked Ham lunchmeat have more added sugar than the same brand's Honey Ham version? Working out as we do, we can manage twice a week soft drinks made from fruit juice and soda water, no added sweeteners, and a small dessert at sunday family dinners (a third of the pie slice or cake slice everyone else cuts), but I, at least, have to know which fruits are high in Fructose and which have more of the other sugars mixed in to even do that, and I skip that dessert completely more often than not.
We've been on this sort of regimen for over 8 years for her and 11 for me. I'm not going to jump at a potential cure, because I'm managing, and I doubt she will want to volunteer for early tests either, but if this leads to a real cure, we can stick to what we do, and in another five years, most of you will be welcoming me and her as your new overlords. I'm expeding effort like what I used to do in my 30's to score 380 on the Army's extended scale APFT, just to stay in pretty good shape for a guy in his 50's. Take away this disease and that effort will again make me a veritable titan, and all Slashdot will tremble at my name. Bwaa-ha-ha-ha! Excuse me, I meant to say I find this prosepective cure moderately interesting.
Re:There's another treatment that stops most T2 (Score:5, Insightful)
Note that the article talks about a TREATMENT and not a CURE. Your diet and workout regime is also a TREATMENT and not a CURE. As it stands now Type2 can go into remission which usually means your GP will take you off of your meds and people think they are "cured" when actually they are not cured, their condition is just in remission and like your account vividly displays: it can quickly flare up again.
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Re:There's another treatment that stops most T2 (Score:5, Informative)
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wall-e (Score:3)
Remember the movie wall-e? All those fat people on the ship, we're going to end up like them if we don't tackle the root problem. A cure for type II diabetes is great and all, but it does nothing to solve the root problem(s).
Old wives tale (Score:2)
Remember the movie wall-e? All those fat people on the ship, we're going to end up like them if we don't tackle the root problem. A cure for type II diabetes is great and all, but it does nothing to solve the root problem(s).
This is an echo-chamber response: someone on the internet heard something, and keeps repeating it. It's rooted in emotional superiority, and comes from someone with no background in scientific research or statistics.
All attempts to pin obesity on the "that sounds about right" reasons have failed, including exercise and food intake - for both amounts and types of food.
In particular, lab animals grown today are fatter than the ones grown decades ago, despite having the same (and well-documented) diets and exe
Evolution (Score:2)
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Environment definitely plays a role. Genes play directly into that, mainly as an adaptation to that environment. Is already well known that if you have relatives with diabetes (of any type) you are more likely to have it, but also statisticians found that Caucasians are least likely to have it, with Asian being higher than most, and Native American (who happen to be mongoloid, just like Asians) having by far the greatest chance of developing it.
And, as recent research turns out, diabetes isn't new to Native
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People show measurable levels of over a hundred chemical compounds (including rocket fuel) which they didn't have 50 years ago.
My bet is on psuedo estrogens given the symptoms.
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I think drinks companies must actually love aspartame. It's basically been arbitrarily chosen to be the focus of wide-spread (and still as of yet largely unproven) hysteria. It the perfect distraction, while they get to pump the drinks with as much sugar as they like.
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If you can't run a 10 minute mile, you are unfit.
You do realise it's possible to be a fit paraplegic, right?
Re:wall-e (Score:4, Interesting)
is caused by a combination of lifestyle and genetic factors
That's the key right there - in the majority of cases, you need the combination.
As many have posted, some people are huge fatties with low cholesterol and well controlled blood sugar. This concurs with the above - they are lucky enough not to have the genetic components.
Type II diabetes is of low incidence in India, but of high incidence in those of Indian-Asian ethnicity living in Western cultures. What's the difference? In India, people eat differently and exercise more. Despite their increased genetic predilection to Type II diabetes, they don't get it from their genetics alone.
The assertion that it has one root cause is false - the human metabolism is a complex system with many factors. The fact that you can't control many of these factors seems to be a vast comfort to some folk, as if it somehow absolves them of responsibility - but it remains true that you DO have control over factors that by themselves can prevent you getting the disease.
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No, that's very wrong. Prior to the 1920's, diabetes was a death sentence. Most diabetics are just so good at managing it that you aren't very aware of what they are going through. Diabetics frequently die from other diseases which were caused by diabetes, heart disease being one of them (also kidney disease, liver disease, and many many others.)
Re:wall-e (Score:5, Interesting)
To quote the infamous Dr. Terwilliger, [wikipedia.org] "I, on the other hand, am inclined to doubt that statement." The most brilliant man I ever knew, Dan Alderson [wikipedia.org] was diabetic and didn't take care of himself. Two years before he was forced to retire for medical reasons, he lost his eyesight to diabetic neuropathy; he was only able to continue because I became his "seeing eye person" and helped him continue to program by dictation. Next, it caused his kidneys to fail so that he had to go on dialysis, forcing him to retire. About a year later, he lost a foot to an ulcer, largely caused by his diabetes. Within a year he was dead. Another friend was concerned about his blood sugar levels and made an appointment to have it checked; before the appointment came, he died of hyperglycemia. I developed Type II twelve years ago and since then have woken up in four different ERs. Diabetes can be, and often is a deadly metabolic disorder. Please learn what you're talking about before you comment on this subject again.
Original Press Srelease from Salk Institute (Score:2)
http://www.salk.edu/news/press... [salk.edu]
FYI--Mayo clinic article on diabetes (Score:3)
Just to level-set everybody.
http://www.mayoclinic.org/dise... [mayoclinic.org]
the race is not always... (Score:2)
but that's the way to bet.
Tobacco smoke boosts FGF1 by 50% (Score:3, Interesting)
As always when a new miracle medicine is hailed in the media, I check the effects of the ancient medicinal plant, tobacco on the same biochemical mechanisms, and it didn't disappoint this time either -- as shown in this paper [wiley.com] (pdf), it boosts the same Fibroblast Growth Factor-1 by 50% (nicotine will do as well in this case).
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You didn't get beyond abstract apparently -- it boosts both growth factors, FGF-1 by 50%, FGF-2 by 100% (see Fig2, p.6 or here Fig2.jpg [flickr.com]).
I'll try it (Score:2)
As a T2 Diabetic for some number of years, I have tried just about every other treatment. Some work. Most don't The cheap ones don't anyway.
Very good news (Score:2)
thank god! (Score:2)
Finally, hope for the most vulnerable among us, the children!
https://www.youtube.com/watch?... [youtube.com]
Strike that. Reverse it. (Score:5, Insightful)
[ I speak as an older programmer, with plenty of diabetic acquaintances and family. ]
I'm afraid there are plenty of Type 2 diabetics whose weight gain was _triggered_ or at least ballooned, under the influence of Type 2 diabetes. The insulin resistance can also cause high insulin levels, which triggers hunger. The spiral of high insulin levels and weight gain can get out of hand very quickly. The result is that people believe that the weight gain triggered the Type 2, not the reverse, especially as the early symptoms are quite modest and only show up with regular blood testing or a glucose tolerance test. It also makes treatment quite difficult, since lapses can leave the victims feeling surprisingly hungry and eager to break their treatment regimes.
There are certainly millions of Type 2 diabetics who'd welcome a much simpler treatment approach: the oral medications do have complications. Injections are awkward, but there are certainly millions of Type 1 diabetics who absolutely need frequent insulin injections or insulin pumps who will say "get over it".
Excitig news or depressing? The latter ... (Score:2)
... granted my understanding is that weight induced diabetes is a self-inflicted wound. Poor diet, no exercise, and it all catches up. But this technology is a money maker for someone, I'm probably just jealous.
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Type 2 diabetes is 90% (or so) self-inflicted. Do you deny a remedy to the 10% innocent victims because of the weakness of character of the 90%?
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The headline is sensationalist. A "cure" could be to find a way for the body to start producing whatever variation on this hormone they come up with to address the insulin resistance, and the insulin sensitivity on it's own, without additional pharmacology. I'm not expecting that to happen though.
Re:Cure? (Score:4, Insightful)
No, but if it removes insulin resistance even temporarily then it can improve the hell out of their lives and dramatically reduce morbidity. Even taking that treatment once a day would be much better than dealing with the constant finger pricks, injections, and constantly having to be careful about what you eat (and I'm not talking about sugary foods, which are obvious and easy to avoid, but rather the glycemic load in other foods that are very much not obvious.)
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Re:what a coincidence (Score:4, Informative)
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You're thinking of Type 1 Diabetes where this is for Type 2.
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You're thinking of Type 1 Diabetes where this is for Type 2.
No, many type 2 diabetics are insulin-dependant.
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A bunch of big-pharma executives are plowing their hookers extra hard tonight. A "cure" that you have to keep taking for the rest of your life, for a relatively common disease. If anything, they are slightly worried the tip of their penis will pop off.
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A bunch of big-pharma executives are plowing their hookers extra hard tonight. A "cure" that you have to keep taking for the rest of your life, for a relatively common disease. If anything, they are slightly worried the tip of their penis will pop off.
Yay! It's the crazy person who believes in crazy things. Next up, vaccines don't cure anything. They're a method of mind control, and that's why research takes forevar!
I am hoping that this drug does work. If it does, then because of U.S. drug patents it will be relatively expensive for the foreseeable future. It has the potential to be the next Viagra, a drug that has to be taken frequently and is very common. Which, would be a sincere reason to celebrate for the executives of the company that brought it to market, no conspiracy/craziness required.
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There's a helluva lot of territory between Tim Horton's and $100 meals.
And what's wrong with fries fried with skin on? Most of the nutritive value of a potato is in the skin.
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How do you lose the advantage of the skin when it is cut prior to cooking? I'm seriously at a loss here.
(As far as your other observations, I don't know. Seems odd to me that you couldn't find something considerably better than TH for considerably less than $100. I suspect part of the problem is not knowing the area and which non-chain restaurants to hit. Chains are almost invariably aimed at the lowest common denominator)
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I definately gained a lot of weight when I moved to the US. Restaurants everywhere, and so cheap, it takes a fair bit of willpower to resist.
Aside for availability and quantity though, its not that different from Europe, especially not Montreal. Sounds like you went to the wrong area of both cities. (All the easily accessible restaurants in NY are just shitty fast food making a buck because of their location, too, which doesn't help)