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Biotech Medicine Science

Injected Proteins Protect Mice From Lethal Radiation Dose 59

ananyo writes "Two anti-clotting compounds already approved for use in humans may have a surprising role in treating radiation sickness. Last year's nuclear accident in Fukushima, Japan renewed anxiety over the lack of treatments for radiation poisoning. It was long thought that the effects of exposure to high doses of radiation were instantaneous and irreversible, leading to destruction of the gut and loss of bone marrow cells, which damages blood-cell production and the immune system. The two compounds are thrombomodulin (Solulin/Recomodulin), currently approved in Japan to prevent thrombosis, and activated protein C (Xigris). Treating mice with either drug post-exposure led to an eightfold increase in key bone marrow cells needed for the production of white blood cells, and improved the survival rates of mice receiving lethal radiation doses by 40–80% (abstract). And yes, the lead author's name really is Geiger."
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Injected Proteins Protect Mice From Lethal Radiation Dose

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