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Biotech Medicine Science

Anti-Smoking Vaccine Is Nearing the Market 237

eldavojohn writes "Almost 6 years ago we discussed a vaccine to help people quit smoking as it entered human clinical trials. Now it looks like the finishing touches have been put on a deal that will go into effect once phase III testing of the drug now called NicVAX is completed. NicVAX was developed by Nabi Biopharmaceuticals, who have agreed to license it to GlaxoSmithKline Biologicals; it is expected to complete phase III testing successfully. Others have fallen short of this goal, in pursuit of a smoking-cessation market expected to hit $4.6 billion worldwide by 2016. Nabi has also sold an experimental vaccine for staph infections; and in 2008 we discussed news of a cocaine vaccine."
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Anti-Smoking Vaccine Is Nearing the Market

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  • Zombieland (Score:2, Interesting)

    by sundru ( 709023 )
    Not sure why it reminds me of this movie .. :)
    • Equilibrium (Score:4, Interesting)

      by betterunixthanunix ( 980855 ) on Friday November 20, 2009 @06:39PM (#30178814)
      To me, it sounds more like the story of Equilibrium...
    • It reminds me of A Clockwork Orange.
  • Well, 'tis said that nothing sucks like a VAX.

  • ?.?.? eh (Score:3, Funny)

    by ae1294 ( 1547521 ) on Friday November 20, 2009 @06:36PM (#30178770) Journal

    Step 4, Anti-Smoking Vaccine
    Step 5, Profit! ...
    Step 8, Anti(Anti-Smoking) Vaccine
    Step 9, Profit!

  • I should get my patents in now!
  • I stopped through it, and so have millions of others. And for less than $20. Screw vaccines. [] Best approach I've ever seen to deconstructing smoking addiction.
  • "Vaccine" (Score:2, Insightful)

    by oldhack ( 1037484 )
    Another useful word lost: "vaccine".
    • Re:"Vaccine" (Score:5, Insightful)

      by RManning ( 544016 ) on Friday November 20, 2009 @06:54PM (#30179044) Homepage

      From TFA...

      NicVAX works by stimulating the immune system to produce antibodies that bind to nicotine in the bloodstream, making the nicotine molecule too large to cross the blood-brain barrier and enter the brain.

      So it effects the immune system to recognize some particular foreign matter and deal with it? That sounds like a vaccine to me.

    • by kindbud ( 90044 )

      Nonsense. Vaccines can be prophylactic, or therapeutic. You just mistakenly think the word has a narrower meaning than it actually does.

    • "Hatsukami said NicVax would probably be most helpful for smokers who already quit smoking and are trying to avoid a relapse."

    • What, vaccine doesn't mean "something related to either preventing or causing more of something"? Next you'll be telling me that theft doesn't mean "something I don't like", and bricked doesn't mean "problems with electronic device that I'm not able to find the immediate cause of"...
    • Seriously. What is an "anti-smoking vaccine"? Do you mean a "smoking vaccine"?

      We have H1N1 vaccines, not Anti-H1N1 vaccines...

  • but I said no, no, give me the goddamn shot.

  • by noidentity ( 188756 ) on Friday November 20, 2009 @06:46PM (#30178918)

    Like H1N1 vaccines, this anti-smoking vaccine will help eradicate anti-smoking once and for all, along with all the ill effects it's caused. People will be able to stop worrying about anti-smoking when around other people.

    (Brought to you by the people who brought you cooler temperatures, larger sizes, wider width shoes, and cheaper price tags.)

  • by camperdave ( 969942 ) on Friday November 20, 2009 @06:47PM (#30178928) Journal
    So, this new vaccine... Does it come in a smokable version?
  • by Reason58 ( 775044 ) on Friday November 20, 2009 @07:21PM (#30179382)
    Unfortunately, this new vaccine is highly addictive. Not to worry though, they are hard at work on a cure for vaccine addiction. It is passed into the bloodstream through the lungs...
  • So these "vaccines" deliver a weakened version of nicotine and cocaine to our adaptive immune systems to condition them to attack the chemicals later?

    Oh, wait, the chemicals are too small for our immune system to detect and disassemble.

    Don't call them vaccines. It sounds stupid.

    • It is a vaccine as it stimulates production of appropriate antibodies to bind to nicotine, which then makes it impossible for it to cross the blood-brain barrier.

  • Vaccine (Score:3, Funny)

    by WilyCoder ( 736280 ) on Friday November 20, 2009 @07:55PM (#30179798)

    My vaccine for both tobacco addiction and alcoholism was marijuana. True story.

  • I think that by the name of the drug this would only affect nicotine addiction. Would be real shitty if it stopped you from smoking healthy things like weed.

    I could briefly see the american anti-drug tsars eyes light up with the thoughts of forced inoculations!

  • Ibogaine (Score:5, Interesting)

    by casings ( 257363 ) on Friday November 20, 2009 @08:06PM (#30179924)

    The only reason why this is necessary is because a compound that already exists is illegal and not profitable. []

    • Re: (Score:3, Interesting)

      by ajlisows ( 768780 )

      Wow. I didn't realize that Ibogaine could be effective for Nicotine, Alcohol, and Methamphetamine as well as opiates.

      I know I'm taking a slightly off topic post and going more off topic, but does anyone have any personal experiences with Ibogaine? I know a few people who have struggled with opiate addiction. It is a struggle practically every day of their lives even after years clean. I have to remain slightly skeptical that one Ibogaine experience has such lasting effects.

  • We at Presscott Pharmaceuticals Have come up with The NIXVacPlug. Just stuff the big cork in your mouth and the little ones in your nostrils. You will quickly discover there is no way to fit a cigarette into any orifice that wont potentially cause you second degree burns. NICVaxPlug, you will know its working if wake up.

    Side effects include:

    • Acute Mangina
    • Nicotine Bum, and
    • Otterosis of the River

    Presscott Pharmaceuticals, bringing you tomorrow's medicines today, whether you like it or not.

  • Now, I feel I must make this disclaimer right off the bat: nicotine is not physiologically addictive for my particular body. However, I have enjoyed a little bit of cigarette smoking off and on over the years -- mostly upon realization that it goes well with drinking. Up until last year, I didn't hang out often with any smokers, but then I met a new friend who ended up filling my empty position of roommate. She, of course, would have been the smoker.

    Thus it became trivial to bum a smoke, whenever. It

  • Seems like they are working on perfecting the Fun Vaccine and pretty soon it will be mandatory because having fun probably kills more people than H1N1 so we need to vaccinate everyone so they can no longer have any fun and live long hellish miserable lives....

  • "...Is Nearing the Market" is a damn far cry from "the first of two Phase III studies, which got under way earlier this month".

    A phase III often lasts years, and considering the potential dangers of messing with chemicals that mimic neurotransmitters, this will be one. Even if the second runs concurrent or nearly so, I expect FDA blessings no sooner than 2016. If they're run serially, 2020+. "Nearing market" like fusion reactors are nearing break even. Slam.

    "NicVAX works by stimulating the immune system to

  • by RobinH ( 124750 ) on Saturday November 21, 2009 @10:07AM (#30183910) Homepage

    I was already vaccinated when I was a kid. My father said, "so help me God, if you ever smoke I will kick your a$$." He meant it too.

Research is what I'm doing when I don't know what I'm doing. -- Wernher von Braun