

Birdsong Studies Lead To a Revolution In Biology 117
Smithsonian.com covers research that began with the study of birdsong and ended by overturning the common belief that adult animals can't produce new brain cells. "Deconstructing birdsong may seem an unlikely way to shake up biology. But [Fernando] Nottebohm's research has shattered the belief that a brain gets its quota of nerve cells shortly after birth and stands by helplessly as one by one they die — a 'fact' drummed into every schoolkid's skull. [Nottebohm] demonstrated two decades ago that the brain of a male songbird grows fresh nerve cells in the fall to replace those that die off in summer. The findings were shocking, and scientists voiced skepticism that the adult human brain had the same knack for regeneration. ... Yet, inspired by Nottebohm's work, researchers went on to find that other adult animals — including human beings — are indeed capable of producing new brain cells. And in February, scientists reported for the first time that brand-new nerves in adult mouse brains appeared to conduct impulses — a finding that addressed lingering concerns that newly formed adult neurons might not function."
Thank god! (Score:5, Funny)
Drink up, fellas!
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My thoughts exactly! Cheers, mate.
*hic*
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Homer no function beer well without.
Re:Thank god! (Score:5, Funny)
So, don't drink because it's now safer, drink because it makes you better looking, funnier, and completely impervious to insults.
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(I am not a doctor and neither is he, we both like alcohol though.
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Yes doctor!
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Re:Thank Cliff! (Score:5, Funny)
In an episode of "Cheers," Cliff Clavin, the trivia-spouting, quirky, irksome mama's boy mailman is seated at the bar describing the buffalo theory to his buddy, Norm Peterson, the beer loving heavyweight bar stool sitting perpetual patron.
Cliff expounds his "Buffalo Theory" to Norm:
Well, you see, Norm, it's like this. A herd of buffalo can only move as fast as the slowest buffalo. And when the herd is hunted, it's the slowest and weakest ones at the back that are killed first. This natural selection is good for the herd as a whole, because the general speed and health of the whole group keeps improving by the regular killing of the weakest members.
In much the same way, the human brain can only operate as fast as the slowest brain cells. Now, as we know, excessive intake of alcohol kills brain cells. But naturally, it attacks the slowest and weakest brain cells first. In this way, regular consumption of beer eliminates the weaker brain cells, making the brain a faster and more efficient machine.
And that, Norm, is why you always feel smarter after a few beers.
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Oh. And here I thought alcohol slowed down the whole herd, making the weak ones in the back (for once!) just as fast as the regular ones...
How did you get that many buffalo drunk?
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By taking them to drink at the rivers of beer draining the slopes of the Beer Volcano, just next door to the Stripper Factory in Pastafarian heaven.
What do you mean - it's not real? But I thought all ... well, I thought ... well, maybe I didn't think at all.
Phew (Score:2, Funny)
I think I brain my damaged.
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well ya (Score:3, Insightful)
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Utter bullshit (Score:3, Informative)
Take a june bug, large and green...tie a string to it's leg and let him fly in circles. At the point where he starts to BLUR, that must be the speed of light. Figure the scale based on RPMs, etc the usual way.
SO: Speed of light: 34 mph!
Seriously: this standard stood for something like 700 years. Science: imperfect.
Wikipedia: Speed of light, history [wikipedia.org]
Physics.virginua.edu: Speed of light [virginia.edu]
Worsleyschool: Measuring the speed of light [worsleyschool.net]
Early, scientific attempts to measure speed of light were very... Well... scientific. And quite accurate. In 1021 an Iraqi physicist realized that light has finite, variable speed that is slower in denser bodies.
In 1629-1667 there were several tries to measure how long it takes for light to move two miles. They all however got to the conclusion that it couldn't be measured because light's spee
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Read up on stem cells.
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What do you thin is going on in the Dentate Gyrus region?
Itis fascinating, but not new news.
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The second option is the correct answer. Say hello to uncle salmon.
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May I advise you to make good use of this new knowledge by growing a few more cells here and there...
So now we can grow wetwear. (Score:3, Interesting)
Re:So now we can grow wetwear. (Score:5, Funny)
Op: Computer, please calculate the optimum trajectory to venus.
chee chee chee... working
Optimal path... CHEESE.
Op: Grr... Computer, please calculate the best stock to buy.
chee chee chee... working
Optimal stock... CHEESE.
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No results for CHEESE... Is this [yahoo.com] close enough?
You need to flip the switch (Score:2)
http://www.youtube.com/watch?v=B_m17HK97M8 [youtube.com]
Bird brain (Score:5, Funny)
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Informative statement: If X = human then they'll be human brain cells.
Alternative funny statement: If they were grown by the brain of an ex they will probably be bitter and angry.
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fat cells and muscle cells, too? (Score:4, Informative)
I learned that nerve, fat, and muscle cells didn't change in number during life*. Seems that's not true about neurons. Apparently also not true about fat cells [wikipedia.org] ("If excess weight is gained as an adult, fat cells increase in size about fourfold before dividing and increasing the absolute number of fat cells present.") Anyone know the scoop on muscle cells?
* - Supposedly weight gain was due to the individual adipocytes getting larger, like a microcosmic obesity. And strength gain was due to more actin and myocin in each myocyte, like a micrcosmic bodybuilder.
Re:fat cells and muscle cells, too? (Score:5, Informative)
I don't know where you studied, but as far as I know, you create tiny rips in your muscles when you work out and new cells are grown to bridge the tear.
Re:fat cells and muscle cells, too? (Score:5, Insightful)
Blasphemy! Each person only has 1 muscle cell that grows larger as they work out. /s
I learned the same things in school myself. We ere even taught that nerve cells didn't get repaired after they were damaged (to the point of dying). Oh, except in the tongue. Those were unique for some reason. And then we started learning that other nerve cells (like in the spine) did sometimes heal, but that perhaps the 'muscle memory' was lost, and learning to walk when you are an adult is much harder than it was as a child. At some point I think we may just have to say, "We don't know what we think we know, and maybe we should just start all over again." We stand on the shoulders of giants when we discover something new, but apparently sometimes it turns of those are midget's, not giant's shoulders, and we are forced to unlearn something we thought was true. Thus goes the ways of science.
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Each person only has 1 muscle cell that grows larger as they work out.
Ah yes, the love muscle...In most slashdotters this is pretty well atrophied from disuse - at least until the pics of a statue of a naked natalie portman covered in hot grits shows up on the intertubes.
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stand on the shoulders of giants
Despite its eternal popularity, this quote doesn't connote meekness or high hopes for scientific progress. When Newton spoke these words he did so not because he felt star-struck or humble, but so might he insult another scientist who happened to be a midget.
So stop quoting it like some sage wisdom out of scientific history. Please.
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Instead, he constructed a grand and insightful statement about science that just so happened to carry a veiled insult. Nothing wrong with that, and it doesn't detract from the meaning of what he said.
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Re:fat cells and muscle cells, too? (Score:5, Informative)
No. That it outdated knowledge and is actually an overworking of your muscles. I know that it's stated again, and again, and again, by people who seem to be experts by all standards. Yet there is proper proof that it's not the right way to get stronger, and actually creates scar tissue. So you might get bigger muscles, but not really stronger ones! The strength comes from the tissue that did *not* rupture,and was allowed to grow.
So it's better to lift a lighter weight more often, than a heavier one just a couple of times.
Re:fat cells and muscle cells, too? (Score:4, Insightful)
"outdated knowledge"
Isn't that a contradiction in terms? If it's wrong now, it was just as wrong when it was being taught... knowledge doesn't get "outdated". Opinions and beliefs and fashionable ideas may change... but not actual *knowledge*.
Pedantic, I know, but I get creeped out by the subtle assumption that somehow the very foundations of reality change under us as the scientific consensus shifts. This sort of abuse of language and the misidentification of beliefs, teachings and opinions with fact, is exactly why the man in the street has grown to distrust "science".
I'm pretty horrified myself if this "muscle tearing" thing is in fact incorrect - because that's what I was taught in high school gym class. It sounded stupid and abusive to me at the time - why should destroying muscle be a *good* thing? - and it was used to justify the "if it doesn't hurt you're not doing it right" idea. If it turns out that that was a flat lie all along... yeah, I'm pretty pissed off. Shouldn't we hold off making *any* such "scientific" pronouncements until we're darn sure, for good and all, that we're NOT just saying crazy wrong things?
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I mean, the current accepted philosophical basis of science is Karl Popper's falsifiability criterion, which is not a monotonic logic... yet we don't have anything like a universally accepted formalisation of nonmonotonic logic [stanford.edu] to deal with this kind of situation (where something believed 'true'at time A becomes 'false' at time B when new facts emerge). There's no standard way of dealing with this in logic - much foundational work was only *started* in the 1980s and the results are still very unclear. So t
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Short answer: No.
If you look at the history of "modern science", from circa Newton and forward, the hard science has been separated from philosophy.
In a way you can say that the philosophers are constantly trying to catch up, and integrate the new knowledge in their world perceptions.
As a whole I do not think that is a problem. We might occationally stumble upon a field or a method that we in hindsight can see was a bad idea, for ethical reasons, but the checks and balances that is built into academia and s
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In a way you can say that the philosophers are constantly trying to catch up, and integrate the new knowledge in their world perceptions.
Only the analytical philosophers, and that's because they limited themselves to "reality," and as such, since reality is best defined by science, they're limited by what science says it reality is.
Philosophy doesn't require science; it is much more vast, much greater, than science. The universe itself (of which science is mainly regarding) cannot encompass all the possibilities of thought. Science, or really, the scientific method itself is a philosophy of truth.
Analytical philosophy is a fad, one which, fu
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I think if you are going to be that pedantic. then it is still ok because of what knowledge means.
Knowledge does NOT mean "what is true."
Knowledge is what is in your brain after learning from the outside world, and reasoning it out yourself.
It is very possible to learn things, and commit them to your knowledge, and still have those things not be completely true, or down right false.
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So it's better to lift a lighter weight more often, than a heavier one just a couple of times.
People differ. I've had more gains from "one max rep" style workouts (where you start at the heaviest weight you can do a single rep with and work down) than anything else. Anyone who believes there is one single optimal workout for all people is ignorant of the real, empirical variation between individuals and not qualified to give workout advice.
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As someone who is tall, slim and has relatively long and narrow muscles, I've always profited most from the "lots of reps with light weights" approach. I don't seem to accumulate any more muscle mass, my weight stays pretty much the same but I can squeeze out a lot more performance from the same muscles without the downsides of lots of actual muscle mass(and without the upsides of looking ripped, if there are any).
Like you said, people differ :-)
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Also, there are different gains from different types of set/rep combinations. Tons of professional strength athletes and body builders can attest to this being true, even if the mechanics behind it are a bit fuzzy. If you do 5 sets of 5 quick lifts with a good pause in between sets, you force your body to adapt to that intensity and duration, building mostly explosive strength and some mass. If you do 1x15-20, lifting slowly on the negative (4-6 seconds) you build more mass than explosive strength. You of c
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So it's better to lift a lighter weight more often, than a heavier one just a couple of times.
I don't know where you get this from but it's complete and utter bullcrap. Your statement alone is incomplete at best, with references to 'lighter weights', 'couple of times', it does not get any more vague than that. Don't listen to this folks, weightlifters don't exclusively do lighter weights and many repetitions simply because it is not optimal for pure strength. If you lift weights regurarly following a program even only for one year, you will know from experience that you need to stress and overload y
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No, the only thing that lifting lighter weights more often will give you is the ability to lift light things many times. That's called endurance. Lifting heavy things less often will give you the ability to lift heavy things. That's called strength. Which one is "better" for you depends on your fitness goals.
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The new cells come from myoblasts that differentiate from satellite cells that exist in the muscle tissue. The damaged muscle cells release signals that cause the satellite cells to do this. The myoblasts in turn develop and fuse together to form the mature multi-nucleated myocytes. In addition to forming myoblasts, the satellite cells also divide to replenish (to a limited extent) the satellite cells that turn into myoblasts.
And it has been known for several years that neuronal stem cells exist in the
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It's true that fat cells can grow and shrink as they are "filled". But laying new cells when you eat a lot is almost entirely a one-way process. When you lose weight the cells lose their stores, but don't disappear. This could be why it's easier to gain weight than to lose it, or why really fat people that lose hundreds of pounds have this flab that ne
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Anyone know the scoop on muscle cells?
I'm not a cellular biologist but I'd suspect muscles have a set number of fibres but that each fibre is made of many cells. Would that make sense?
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So where can I get this rhabdomyocsarcoma if which you speak?
Also, does it turn your skin green..?
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Anyone know the scoop on muscle cells?
Like everything else, it probably varies with person. My strength has increased about 50% in the past nine months (check out the Big Five workout and the book "Body By Science"--best workout I've ever used.) but my bulk has hardly increased at all--I'm a hard gainer.
This is also true of the brain, as anyone who has studied anything about strokes in the past 20 years (since the advent of CT) has known: some people have highly plastic neurological function, so the destr
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Well, duh. (Score:5, Insightful)
I don't mean "duh" to the researcher -- obviously things must be tested and validated in the real world, not just postulated -- but it never made sense to me in the first place that brain cells can't regenerate. Why the hell not? What is the adaptive purpose of such a limitation? The brain consumes a huge amount of energy, much more so per-pound than any other organ in the body. That seems to imply that the brain is extremely important to the organism. Why would essentially the most important organ in the body have such a stupid limitation that it can't even recover from MINOR damage? That makes no sense.
One possible explanation for the very limited growth rate of brain cells is that if this growth rate were not tightly controlled, it could lead to "chaotic" brain tissue which could interfere with normal brain function. So general division of brain cells would not be desirable -- but I'm no neuroscientist.
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Cancer is the uncontrolled division of cells. I could see an evolutionary incentive to stop all (or most) cell division at some point, so that the cells that are dividing (cancer) can be controlled and eliminated by the body.
But I do agree with you. I always thought they had it wrong too.
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I don't know - the thought of my brain cells continuing to divide makes my head 'splode!
Re:Well, duh. (Score:4, Informative)
I don't mean "duh" to the researcher -- obviously things must be tested and validated in the real world, not just postulated -- but it never made sense to me in the first place that brain cells can't regenerate. Why the hell not? What is the adaptive purpose of such a limitation? The brain consumes a huge amount of energy, much more so per-pound than any other organ in the body. That seems to imply that the brain is extremely important to the organism. Why would essentially the most important organ in the body have such a stupid limitation that it can't even recover from MINOR damage? That makes no sense.
One possible explanation for the very limited growth rate of brain cells is that if this growth rate were not tightly controlled, it could lead to "chaotic" brain tissue which could interfere with normal brain function. So general division of brain cells would not be desirable -- but I'm no neuroscientist.
I am, and you're right in nearly every detail. I'd only add:
- New growth would consume energy that the very hungry brain would prefer not to waste that way.
- Brain function develops by strengthening some of its connections, but losing far more. You're born with 4 times the connections you die with. There's no need for new cells in terms of function.
- It actually is in repair that 'chaotic' growth occurs. Neurons are notoriously stupid when it comes to regrowing back in the same place. Severed nerve trunks try to grow back together but get tangled and miss connection, make incorrect connections, or simply turn back on themselves in a tangled "stump neuroma". Some (but not all) of this occurs because the 'interneurons' that act as the telephone poles to the neural wires also get damaged and/or die.
- There's good progress made in getting neurons to regrow and reattach properly, using techniques of treating the cut nerves with certain things and/or using host stem cells. I'm not fully up on the details, but I will be once I read a copy of my son's dissertation; he defended it last month and is just finishing the revisions. I do know that in some cases even severed spinal cords could grow back correctly enough for partial function if treated soon enough with a particular substance. That substance is a common food additive, so phase 1 clinical trials might be skipped. The hope is an injectable treatment would be available to emergency workers which, if the testing bears out the initial studies, would give people with severed nerves more than half their original function in more than half the cases.
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So junk food is good for you. You could even say it is "brain food."
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I do know that in some cases even severed spinal cords could grow back correctly enough for partial function if treated soon enough with a particular substance. That substance is a common food additive, so phase 1 clinical trials might be skipped.
You may have ethical reasons for being vague about what exactly this "substance" is, but given what you've said here, I'd wager you're talking about glutamate?
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I do know that in some cases even severed spinal cords could grow back correctly enough for partial function if treated soon enough with a particular substance. That substance is a common food additive, so phase 1 clinical trials might be skipped.
You may have ethical reasons for being vague about what exactly this "substance" is, but given what you've said here, I'd wager you're talking about glutamate?
Glutamate is a transmitter precursor, not a growth promoter.
I didn't know whether the news was out about this stuff or not so I had to find out first. Turns out I'm way late in catching up on my son's work. The Wikipedia page on this stuff references a 2001 study done at Purdue; that was the lab he worked in as an undergrad.
Polyethylene glycol. Since 2006 it's been allowed as a direct additive http://www.epa.gov/EPA-IMPACT/2006/March/Day-13/i2354.htm [epa.gov]
Go to PubMed http://www.ncbi.nlm.nih.gov/sites/entrez [nih.gov] and
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There was an article a few months back about using blue food dye in spinal cords immediately after injury having a significant effect. Possibly this is what you are thinking of?
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I'll see your 'Duh' and raise you a 'not really news'.
See this BBC News article from 2000 [bbc.co.uk] which describes how, "part of the hippocampus grew larger as the taxi drivers spent more time in the job." Navigating the streets of London for a job requires more spacial memory and reasoning so that bit of the brain grows.
Hardly a breakthrough or a suprise, unless I'm missing something?
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Um, what? You say that like it's a bad thing. I bet you also call politicians "flip-floppers" and say they have "weak leadership" when they change their policies based on global and local events. There's a place for unquestioning adherence to the status quo, but that place is not in scientific research.
Oh wait, I get it, you're a troll parodying those Intelligent Design drones. Damn, you're good.
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Saying "i've never seen it" or "i don't expect to see it" is not science. One's just an observation, and the other not even a prediction, yet alone a theory.
You may as well call "i don't expect to see margaret thatcher's bare ass" science. It's not, even if you're wearing a lab coat when you say it.
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I don't see why the parent post was rated "Troll", nor do I understand the other replies to it. The parent is expressing that "There's hope for us yet." We can hold very entrenched scientific ideas, but are not unwilling to discard them when presented with evidence of their falsity. This is a good thing, and I think the OP was just pointing it out.
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So a scientific view that is considered the "settled" "consensus" view can change in the face of contrary evidence? That's good to know.
That's exactly correct. That's precisely how science works, and it wouldn't work any other way. When you continue to believe something in the face of contrary evidence, that's called being (1) irrational, (2) stupid, or (3) both. Had you paid attention when the teachers were trying to explain this, you wouldn't be (1), (2) or (3).
But I will add that, as noted below, just because you're (1), (2) or (3), you're only wrong, not trolling. Someone who mods a comment down just because it's wrong is both (2), and
Science is a discourse, not a religion (Score:3, Insightful)
Revolution? (Score:2, Interesting)
There was another study dating cells based on inclusion of radioisotopes left over from atmospheric nuclear weapons testing, apparently finding a very slow rate of new cell generation, measured in something like percent (or fraction thereof) per decade of the total. And their study only holds true if they correc
Um... (Score:1)
Weed (Score:1)
Beliefs of scientists (Score:2)
It's amazing how strong many scientists believe in certain things that are not even theories, and have a hard time changing their minds in the face of evidence to the contrary. We saw it with 'junk DNA' (long strands of DNA between genes that apparently had no purpose, so scientists decided it must be junk left over from evolution), stem cells, and now the dogma that certain types of tissue can't regenerate. Luckily they are proven wrong time and time again, which keeps biology exciting and opens new possib
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It's amazing how strong many scientists believe in certain things that are not even theories, and have a hard time changing their minds in the face of evidence to the contrary.
Why should we scientists be any different from the rest of you? We're people acting like people do, we just happen to be trying to figure things out in public. Besides, we have to believe something as a starting point so we can test an idea, and when we do have evidence, develop a theory which we can then further test to find out where we're wrong, discard that, and repeat the process. A science example of this is solar neutrinos. Despite many well designed experiments using well tested devices, only one th
It's limited (Score:2)
Fact is, regeneration of brain cells is very, very, very, very limited. In the case of severe brain injuries, it basically doesn't happen. (the reason recovery is possible is due to rerouting around the damage by cannibalizing existing cells). This depressing fact has been well known to neurologists and neurosurgeons for at least 50 years. Now, as it may turn out, there actually IS a little bit of regeneration. That doesn't change the fact that even if it happens a little bit, for all practical purpose
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Take the example of a Hemispherectomy. A huge portion of the brain can be disabled, and depending on the patient, relatively few complications result.
Think about the redundancy built into that system that would be necessary for this to happen.
What depresses me is the notion that brains aren't going to get better. It seems more like, if we could remove the damaged portion another would eventually take over. Coupled with this new 'new brain cell' information, now I'm wondering if we should be trying to fin
who came up with this silly idea, anyway? (Score:1)
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Guess what. If you seriously damage some part of your brain, it w
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Haha... except the bit where they had wrong what I had right.
brains own (Score:1)
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Maybe it's because the adult skull is rigid - if large parts grew, you head would explode! Or at least your eyeballs would pop out.
Brain Cells vs Fat Cells (Score:1)
biology is not destiny (Score:2)
The plasticity of the brain was already known to be very high. Now we have reason to believe it's even higher than previously known. Genes are great, I love 'em, but a lot happens after conception.
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