martyros writes "Researchers at the Baylor College of Medicine are performing clinical trials of a vaccine that teaches the immune system to attack cocaine, preventing it from giving a high. The vaccine is made by attaching inactivated cocaine molecules to the outside of inactivated cholera proteins. When the immune system attacks the cholera proteins, it also 'learns' the cocaine molecules as well. The result is that the immune system 'recognizes the potent naked drug when it's ingested. The antibodies bind to the cocaine and prevent it from reaching the brain, where it normally would generate the highs that are so addictive.'" An earlier story from The Star notes that human trials for vaccines against both cocaine and nicotine are well under way.
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