Team Claims Synthetic Life Feat 112
gertvs writes "According to the BBC scientists in the US have taken a step towards producing life from scratch in the laboratory by having successfully transplanted an entire genome from one bacterium cell to another. This technique could possibly lead to the creation of 'designer' microbes producing fuel or help cleaning toxic waste. 'The ultimate plan is to stitch together artificial chromosomes, proteins and other building blocks with the aim of jumpstarting their designer microbe to life. But Dr. [Craig] Venter concedes that this may be a long way away, but he says he has taken an important key step towards that goal. His team, essentially, snatched the body of another life-form and invaded it with a new genetic code. This, he says, will be a key tool in testing the artificial chromosomes - or DNA bundles - he plans to make. '"
Origins Of Life? (Score:4, Funny)
Patents.... (Score:5, Funny)
i am... (Score:2, Insightful)
"designed microbe is able to clean water from toxic waste" and a few months/year later: "water-cleaning microbe causes " and some random illness/problem. genetic engineering is full of possibilities, it's the humans that haven't shown responsible behaviour with new technologies.
Shades of "Zodiac". (Score:1)
Imagination needed (Score:2, Funny)
Oh come on! Have an imagination! This could make some really killer bioweapons! Or we could mine deer for oil. Convert puppies into kittens. Give George Bush a brain. Think of the implications!
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Penrose (Score:2, Interesting)
Other uses could be to adapt humans to non-terran environments. Base-line in brain just tailored to an alternate environment.
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Other uses could be to adapt humans to non-terran environments. Base-line in brain just tailored to an alternate environment.
What part of that statement was interesting?
If the bum down the street turns out to b
Re:Penrose (Score:4, Interesting)
You definitely don't NEED quantum computers to reproduce intelligence. That's because IF cells contain quantum computers, then they must work in cycles: load initial data, process it, read data. Reading computation results stops quantum computer (collapses it to one state). Even Penrose admits that quantum computers can't work more than a fraction of second in a living cell.
Quantum computers can be simulated by classical computers (they're computationally equivalent), so quantum computers are not NEEDED to simulate human mind.
However, quantum computers might make good accelerators for neural processing (there are several publications on this).
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For example a background process considering possible escape routes: "what if I jumped on to (various portions of) that branch or other branches, would they hold my weight, would they lead to better escape routes?". All considered in parallel.
Then the animals start simulating each other (predicting the decisions of a potential competitor/predator is very useful), and
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Thinking about branches requires work of more than one neuron, so quantum computers are not really significant here (they can't talk to each other through cell walls).
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Some people even have a "Halle Berry" neuron - if they see the name "Halle Berry" or her picture or even a caricature, that neuron will fire.
See: http://www.physorg.com/news4703.html
Maybe that part is a bit like Bingo. Patterns are passed through a huge bunch of neurons, and one of them shouts out and says "Bingo: Halle Berry!", another says "Bingo: Catwoman", and t
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QCs (if they are present inside neurons) are probably advantageous, but it doesn't mean that they will be the fundamental barrier for creating 'artificial brain'. However, it may be practically impossible to build artificial brain without some sort of QC accelerator (i.e. like videocards - you can build games which use only C
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Quantum computers can be simulated by classical computers (they're computationally equivalent), so quantum computers are not NEEDED to simulate human mind.
That's not quite true, Quantum computation (perhaps not in the sense your talking about) is more powerful than classical computing in one respect. That is though Quantum randomness a Quantum computer can produce an endless supply of real random numbers. A classical computer can only produce pseudo-random numbers, a way round this is to include a large enough supply of random numbers in the initial configuration. It's not what Penrose was talking about I know but...
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AFAIR my university's course, Turing machine with random number generator is computationally equivalent to a common Turing machine.
Your university course is wrong? Here's a problem a common Turing machine can't solve:
Using a program of length n produce n+1 "really" random numbers.
Quantum events are as far as I understand the only source of "really" random numbers we have and are just plain weird. The problem comes in part because we don't have a clear definition of random.
Anyway, I've not read this article yet but it looks like it could be of interest: http://www.nature.com/nature/journal/v318/n6041/ab s/318041a0.html [nature.com] .
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We can have pseudorandom numbers behaving exactly like real 'random' numbers (though it requires unlimited resources as you get more and more numbers). I.e. you won't be able to distinguish pseudorandom generator and real random source.
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What is 'really random number'? Can you define it?
A random number source is that which produces a (infinite? or unbound finite) series of numbers which can not be produce by any deterministic algorithm in space less than the size of the number series... Basically the numbers produced by the generator have a high Komolgorov complexity.
We can have pseudorandom numbers behaving exactly like real 'random' numbers (though it requires unlimited resources as you get more and more numbers). I.e. you won't be able to distinguish pseudorandom generator and real random source.
That's not so. The Kolmogorov complexity http://en.wikipedia.org/wiki/Kolmogorov_complexity [wikipedia.org] of a string of pseudo random numbers is very low, by definition I can build a finite length program to produce an infinite string
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However, you can't readily tell it from its output. It might well be possible, that the Universe uses a simple formula to determine the outcome of quantum events.
In any case, we can just add hardware-based random number generator to classical computer simulating quantum events.
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I take a large sample of it's output, I enumerate all possible programs shorter than this output, I run these programs and find the smallest program that outputs this string and then halts.
It's possible, though as I said, it's my understanding that most modern physicist wouldn'
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That point isn't a critique of his hypothesis. IIUC, Penrose's model of the human mind simply includes quantum mechanics as an ingredient in it's operation. You might as well claim that my Athlon isn't really computing because every time its innards clock through an op it shuts down (loses conciousness?) for 1/2,000,000,000th of a second.
You definitely don't NEED quantum computers to reproduce intelligen
Mutation (Score:2)
Well it's perfect that we could just program a microbe to solve all our messy problems just like snapping my fingers.
Now.. some mutations have been observed when the microbe was released in the wild. Of course, releasing in the wild means that your creation kinda gets a life on its own. Some mutations have been observed.
Mutation one turns the form of liquid metal that wants to kill John Ko
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Mutations are almost always:
1.Useless
2.Harmful in some way to the creature
3.Lost in the next generation(assuming the creature can breed)
So, a little more 5 legged frog, and a little less sharks with freakin laser beams.
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Mutations are almost always:
1.Useless
2.Harmful in some way to the creature
3.Lost in the next generation(assuming the creature can breed)
So, a little more 5 legged frog, and a little less sharks with freakin laser beams.
You're boring, you know that? But, ok, I'll accept your science ways, and take the 5 legged frog. But only if can laugh in an evil voice and has an army of minions trying to take over the world.
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Yes, but mutations are obviously sometimes beneficial to an organisms survival. I think the point is that if we create a completely artificial gene/set of genes/organism then we don't really know what trajectory it's evolution will follow in the natural world. Organisms en
Re:Mutation (Score:4, Funny)
"No, that's the beautiful part. When wintertime rolls around, the gorillas simply freeze to death."
The Venter Institute (Score:2, Funny)
On the other hand, the field of Artificial Life is small. Something on the order of a thousand other people are qualified to talk about this intelligently. So my hopes for discussion are pretty much nil.
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Wolfram still compared negatively to Venter.
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OK, Craig Venter is humble compared to that moron. Smart - but still a moron.
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When I took the class on the Philosophy of Life (focusing specificially on defining life for the purposes of knowing if an artificial creation is "actually" alive, which involved studies in computation,
Paging Mary Shelley... (Score:2)
Especially since one of the best thinkers about it isn't around anymore, except for her words...
So they pretty much did... (Score:3, Informative)
We'll have Artificial Intelligence (synthetic life by my standards) I think, long before we're actually engineering proteins and building an original base DNA sequence of our own making and creating the cell to run it from scratch.
At which point our machine overlords will take care of the rest.
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I highly doubt it. Think of the relative complexities of a computer capable of simulating the human brain (and by that I mean capable of running several hundred million threads, each of which runs an interruptable O(2^n) algorithm quickly enough to respond to external stimuli) to
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They did something very different from a virus (Score:5, Insightful)
Venter's group has taken a cell and replaced ALL of the original DNA with the newly introduced DNA. (I believe a virus replaces nothing, it merely adds its own genetic code). While the newly introduced DNA comes from another bacterium, there is no reason to think that the DNA from a completely "man-made" source couldn't be introduced instead. By introducing fewer and fewer genes, Venter (and others) hope to find the "minimum" number of genes needed to make a living creature.
Once this minimal life is created is new, possibly never before seen in nature, genes can be introduced one at a time. Because these genes are added to a "clean" slate, their functionality and efficiency can be controlled and optimized. Kinda like a much more powerful version of the transgenic mice they use in research where they selectively eliminate just ONE gene from the mouse strain to see what its effect is. I believe they have strains for all/almost all the thousands of genes in mice so they can evaluate them for various genetic ailments, disease resistance and whatnot. (Harvard was the first to get a patent on the genetic code of one of these mice: the first patented life. Go Harvard!)
Here instead of removing one gene from the entire set (to an admittedly MUCH more complex organism), Venter will be able to control ALL the genes in his bacteria. This will greatly reduce/eliminate unwanted interactions (because the "unneeded" genes have been eliminated) allowing R&D to go much more quickly. Thus the optimism on creating oil producing bacteria. (Please note that "unneeded" refers to our needs not the bacteria, we can make a bacteria that is alive but is utterly dependent on vital nutrients that "wild" bacteria make themselves. Since our bacteria is simpler, we will use it not the wild version.)
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Exactly. You could do the same thing that Venter is doing using a virus to infect bacteria, but the real goal is to be able to strip out all the excess cellular processes that would otherwise be
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It's even worse than that to be honest. Experiments like this were how we discovered that DNA was the "transforming principle" in organism life. Basically Oswald Avery took a pathogenic (disease causing) strain of bacteria and isolated the DNA then transfered this to a non-pathogenic strain and noted the associated transferal of traits (the non-disease causing strain became disease causing). http://en.wikipedia.org/wiki/Oswald_Avery [wikipedia.org] (this was way back in 1928). This is no huge leap as far as I can see. Eve
Forget nuclear weapons (Score:2)
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The human race is not going to go extinct from just the loss of technology, barring massive environmental collapse in which case we would probably need our tech to survive.
Plenty of people around the world get by from day to day using only the level of technology that they themselves, or rather the people in their local area, can support.
Unless by extinction of the human race you meant the extinction of pampered westerners?
Sure we might get kno
Sounds Good, But.... (Score:2, Funny)
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Synthetic Life Feat (Score:2)
Oh feat, right. As you were.
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When you come right down to it, life is fancy chemistry and nothing more. Life could also be described as "really fancy physics," if you wanted to. There is no clear line between when chemistry stops and biology begins, hence the term
biochemistry.
On the contrary, all life is made by one of life's own evolutionar
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The brain is basically an enormous collection of cells performing primary metabolism (which presumably was functioning) but that also has loads of secondary metabolic pathways in the form of electrochemical communication.
This is why drugs exist (LSD, ritalin, halothane, take your pick) that can have a profound effect on consciousness: they change the chemistry of the brain.
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If anything, that just serves to illustrate my point. Life is not always simple, binary function. If you lack a heartbeat, you're said to be clinically dead, bu
Wow, that's amazing (Score:2)
Seriously (Score:1)
Horror Movie (Score:2)
Sounds like somthing out of a science-fiction horror movie.
Patent tomfoolery (Score:1)
Slashdot the Nerds National Enquirer (Score:2)
No they don't. From the article....
The took genetic material from one species and i
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What is the big deal? (Score:2)
Update Re:What is the big deal? (Score:2)
In other terms this
more quotes Re:Update Re:What is the big deal? (Score:2)
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Depends on what you mean by practical. If you mean easier for us to do, then yes. However, the point is to create a synthetic organism that is engineered to make a single product. So it makes more sense to strip out all of the extraneous genes/processes that are not necessary for production of that compound. As an example, in a standa
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Not really. If you are designing an organism for a specific purpose then you only need a minimal set for critical life processes and for producing the target compound. Most bacteria have a wide variety of metabolic genes for utilizing various macromolecule nutrients for energy, which are largely unnecessary if you are going to be feeding it a specific nutrient broth, so you can chuck out a bunch
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And, again, why is it necessary to strip it down to "minimal" amount of genes?
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The number of pathways known (or unknown) that a given gene is involved in is irrelevant from their point of view. If they can knock out a particular gene and have the organism still grow at the same level and produce compound X, then that gene is unnecessary for their purposes.
And, again, why is it necessary to strip it down to "minimal" amount of genes?
Primarily because production of "unne
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Which is exactly why they have genes that are unnecessary for the purposes that Venter's group is targeting it for. In fact part of the patent application describes the medium that they plan on using:
The inventors have identified 101 protein-coding genes that are non-essential for sustaining the growth of an organism, such as a bacterium, in a rich bacterial culture medium, such as SP4. Such a culture medium contains all of the salts, growth factors, nutrients etc. required for bacterial growth under laboratory conditions. A minimal set of genes required for sustaining the viability of a free-living organism under laboratory conditions is extrapolated from the identification of these non-essential genes. By a "minimal gene set" is meant the minimal set of genes whose expression allows the viability (e.g., survival, growth, replication, proliferation, etc.) of a free-living organism in a particular rich bacterial medium as discussed above.
it makes more sense to me to add necessary genes to some tough badass bacteria that can it dirt and make a living on it.
I disagree. The more self-sufficient your bacterium is, the higher the likelihood of it surviving outsi
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This is utter nonsense, which I do not consider necessary to consider for answer.
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LOL, so you apparently know of some strain of bacteria that is capable of violating the laws of thermodynamics? If you have X amount of input energy in the form of nutrients and Y is the amount of energy consumed by the cell for life, then X-Y will equal the amount left over for other things like reproduction or in this case biosynthesis of a compound. In an organism that has extraneous cellular processes such as the abili
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Call me an extremist, but this looks like Venter's ego trip...
Interesting, but... (Score:1)
Also, be warned that I will be as scared as I will be impressed when they do write their own software for the hardware.
IT'S ALIVE (Score:2)
Change chimp to man (Score:1)
- Take chimp single celled embryo right after fertilization
- Chimp gene is 99% similar to human, so change the genes that differ in the embryo and make it look exactly like a human embryo (make it look like Dubya's genome.. he won't be convinced otherwise)
- Will we get a Dubya clone from that embryo ??
More improtantly, does this mean that any animal can be turned into a human (or any other animal, for that matter ) ?
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Good thing I read the headline twice ... (Score:2)
I need another beer.
Intelligent Design (Score:2)
Well, what more proof do you need?
/me ducks.
stubborn? (Score:1)
Again just my
Teen Claims Synthetic Life Feat (Score:1)
Stop the B.S. Gee Whiz headlines (Score:1)
merely synthetic DNA; 30K other chemicals (Score:2)
Vitalism contends there is some important constitute to life outside of known chemistry and physics. Some "neo-vitalists" claim life can only come from existing life, or some pattern thereof. Others claim mysterious new phsice like quantum microtubes, etc.
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Re:Inteligent design (Score:5, Funny)
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In fact that latter idea is pretty critical to a lot of the less nuanced creationist arguments against a natural origin of life: there have been plenty of claims t
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Sure it would, because ID is ALWAYS about the Christian God in the USA in a political context.
Says who? I live in the US as well, and have never restricted the ID debate to a guy with a white beard and robe. I vote.
Sure, aliens could have designed us, but that's not what they really mean in a practical sense.
"They" who? Mighty dangerous to lump ANY group of people together like that... and who are you to tell us that we've not already allowed for that possibility? Here, I'll take ya one further... What if [and I don't personally believe this is the case] Jesus was sent along by those same scientists as a "litmus" test of our development? Did we flunk?
Jus' some thought fodder... {or
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