Human Blood May Contain A Cure For AIDS 309
Lisandro writes "German scientists at the University of Ulm have identified a natural ingredient of human blood that prevents the HIV-1 virus from from infecting immune cells and multiplying. The molecule, which they call virus-inhibitory peptide (VIRIP), promises new types of effective treatment for HIV in the future. 'Tweaks to its amino acid components boosted its anti-HIV potency by two orders of magnitude. Tests also showed that some derivatives of the molecule are highly stable in human blood plasma, and non-toxic even at very high concentrations. A synthetic version of VIRIP also proved effective at blocking HIV, excluding the possibility that some other factor was responsible. VIRIP targets a sugar molecule which HIV uses to infect a host cell. '"
the real solution made apparent (Score:3, Funny)
Well clearly then, the real solution is to destroy all the sugars in your body!
Good for them though, lets get this solved.
Re:the real solution made apparent (Score:4, Informative)
No, that is not a sad comment on the human diet, it is instead an explanation for why we like sugar so much, it is so usefull and neccessary.
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And all this time I thought I liked sugar because it is sweet and delicious!
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Re:the real solution made apparent (Score:4, Informative)
Our primitive ancestors who enjoyed (and could metabolize) sugar (and fat) were able to get much more energy into their bodies. They were better adapter to an environment where finding food/energy was difficult.
So yes, you ARE genetically predisposed to like sugars (and fat foods).
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Comment removed (Score:5, Interesting)
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Wrong hole! Wrong hole!!
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It's useful, but not necessary. The body can run on ketones.
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10g carbs isn't even hardly worth mentioning.
This is true, although once I started working out regularly (three times a week, one hour per workout) I stopped losing weight anyway :)
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In a heavily carb deficient diet, the body is forced to cleave fat and send it through some extremely inefficient metabolic pathways to convert it to carbs just to keep your brain, peripheral nerves, and all of those in between running smoothly. In addition, your liver's and muscles' carb/glycogen reserves are near-co
Re:the real solution made apparent (Score:5, Informative)
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I was on something like the Atkins diet, but I didn't buy a book or anything. I just kept my carb intake below 50g/day religiously - NO CHEATING - and the weight dropped off. For the first nine months I was pretty much sitting on my ass and consistently lost ten pounds a month.
I wrote the following two articles about the atkins diet and the food pyramid [everything2.com] and what to eat on the atkins diet [everything2.com]
Re:the real solution made apparent (Score:4, Insightful)
I'd suggest stopping the low carb diet once you hit somewhere below 15% bodyfat. A good indication is when what might be a spare tire turns into more of a small set of saddlebags, and you've got decent definition in your arms.
You've got at least two, probably 3 or 4, years of growth left in you, and it would be a pity to stunt your growth due to any deficiencies in nutrients you suffered losing weight you could lose later anyway.
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That's interesting, especially since your link says "Many promoters of dietary schemes would have us believe that a special substance or combination of foods will automatically result in weight reduction. That's simply not true. To lose weight, you must eat less, or exercise more, or do both." This is, of course, not true. As you and I both apparently know (since you said it would produce weight loss) you can lo
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No, that if they can either synthesize it or develop a biosynthesis process, they can produce it in large quantities and inject that, augmenting the body's natural supply to increase its resistance to infection by the AIDs virus.
well... (Score:5, Informative)
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Yeah, I've heard it said that if you can't get laid the day they cure AIDS...you've got some serious problems.
I wonder, if when they do cure it..if we'll see an even greater fall in the number of marriages, and increase in divorce? I know lots of men that married...they found a healthy partner, and if faithful in marriage..well, no chance of aids really.
But, now
Patent Pending (Score:5, Funny)
God
Dear God. (Score:4, Funny)
Sincerely
Steven Hawking
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Yours Truly,
YHWH
Re:Dear God. (Score:4, Insightful)
I mean really, you simply ARE. Real Godheads neither exist nor don't exist.
Sincerely,
Brahman
So: how long will it take HIV to evolve ... (Score:2)
It's out to reproduce, that's its job.
RS
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How'd it get THAT job? I'm gonna kill my guidance counselor...
Re:So: how long will it take HIV to evolve ... (Score:4, Insightful)
I am not a scientist, but there is no guarantee that this particular strain of HIV can exist without that sugar molecule, or that evolution will occur fast enough to save the species. For example, this may be like removing oxygen from a human environment. Sure, we may one day evolve the ability to exist on another common chemical, but we could never do it in time, if a natural catastrophe should strike.
This could be an excellent argument for organizations trying to distribute AIDs drugs in third world nations (once they get their hands on this one), since the practice of curing only those who can afford it would simply allow the virus to exist long enough to evolve (if possible), whereas curing everybody could could make it go the way of polio and small-pox.
But, I reiterate. I am not a scientist, so the next person to read this may point out where I am wrong.
Weird (Score:4, Funny)
Now is that the definition of irony or what?
Tired of hearing it (Score:2, Insightful)
I really hope that this turns into something, but until one of these new finds turns into a cure or at least a vaccine I'll still be seeing freinds die.
I'm just sick of hearing of new breakthroughs and then not hearing another word about them.
How many friends??? (Score:2, Insightful)
When it comes down to it - HIV and AIDS are very easily preventable diseases. Anyone who takes proper minimal precautions will not get HIV or AIDS, unless they are maliciously targetted or woth in a health-related field and/or are VERY unlucky.
Personally I have always felt the absolutely enormo
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AIDs is not as big of a problem in western nations as it is in some parts of Africa, w
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Two close relatives have died, and one more is currently living with being HIV+.
I'm sorry if you don't believe me. Doesn't matter if you do or don't. Was just putting in my two cents.
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wow, im sorry to hear that but even you have to admit that you are on the statistically short end of the stick here. It is fairly unusual for anyone not involved in AIDS care to know that many people with HIV.
Still, im sorry for you losses.
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It is a terrible disease but everything you said right after that is absolutely asinine.
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I have lost two people so far to this disease in my life, and I have more than 5 friends that are HIV+ today.
To say that type 1 diabetes, a treatable disease, deserves more money than HIV/AIDS research is absolutely ludicrious. Type 1 diabetes will kill you if left untreated. HIV/AIDS will kill you, period. The retrovirals help extend your life, but have no doubt, it is a terminal disease. Have you ever seen someone die of HIV/AIDS
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People with Type I diabetes lives are no picnic. Imagine telling a 1 year old child they have to inject a needle ito themselves 3 times a day for the rest of their known lives. Imagine having too explain to everyone you aren't a junkie, you are a diabetic, every time they see needles all over your house.
There is a HUGE DIFFERENCE in morality between
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yes, you can be. if your mother had it, odds are damn good you will.
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I'm not allowed to expect people to be accountable for their mistakes? I have been and it sucked a lot.
I'm not allowed to prefer curing a disease that attacks anyone and everyone regardless of what they do or who they are over a disease that is almost entirely preventable?
There was no troll there. You should be ashamed of yourself.
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- peopple get infected with HIV by mistake all the time, there are many cases of tainted blood transfusions across the world. Also some of those infected with the virus spread it on purpose, they feel that if they got it, they should take as many people with them as
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you failed
"HIV and AIDS are very easily preventable diseases."
So is the common cold, and the method is pretty similar, just never touch anybody else.
"even if it is their fault they became infected"
The real reason that you don't want to see money spent on AIDS research, your basic belief that they deserved what they got. Good thing you're never done anything stupid in your life.
Lung cancer and diabetes are also due to lifestyle, but nobody is blaming the victims they way th
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The OP said type 1 (aka juvenile) diabetes, which is not preventable and has nothing to do with lifestyle. Type 1 is an auto-immune disease, where the insulin-producing cells are killed off by the body. Type 2 (aka adult-onset) can be associated with lifestyle, but isn't always. My father-in-law got type 2 simply by getting old, not fat.
Re:How many friends??? (Score:4, Insightful)
While blaming the victim is rarely worthwhile, this is a disease that could basically be eradicated by education, testing, and self control. The reason it's spread so widely is that people aren't into any of those things.
Re:How many friends??? (Score:4, Insightful)
I still think coming out of the body of someone who is HIV positive qualifies as "hard to get this disease", and "drinking the breast milk of an infected individual" is pretty high up there as well.
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When it comes down to it - HIV and AIDS are very easily preventable diseases.
That may be true, in the same, clinical way that lung cancer and obesity are easily preventable diseases. The complication arises when you try to change human behavior on a societal level. People consume carbonated soda and french fries becase it tastes good! People smoke because it feels good! The same is true of sex and IV drugs.
Add to this the fact that humans are very bad at assessing risk, and you have a recipe for the HIV epidemic.
Re:How many friends??? (Score:5, Insightful)
Sure, some people weren't as careful as they should have been and got infected, but guess what... They live in the same world with the rest of us and can subsequently spread their illness. This is a public health issue. Morality judgements of people infected with STDs don't bring about cures for them any faster. Nor does the attempted imposition of the same morality on the rest of the, as yet, uninfected population seem to be having much effect in slowing down the spread either, let alone stopping it.
How 'bout instead of taking research money away from HIV and giving it some more morally worthy disease, we just resolve to spend more research money on all of them and stop making questionable moral assessments of sick people.
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I believe this is fairly false. Just about the only way to ensure you do not contract HIV is to not have sex with anyone. You cannot always have sex with a condom, because then you cannot have children. (And of course, condoms fail.) Even if a person only has sex within a monogamous relationship (which for some people is not a "minimal" pre
Re:How many friends??? (Score:5, Insightful)
Errr... the problem with HIV/AIDS in Africa is a cultural and economic one, not one of "can't be prevented."
The use of condoms drastically reduces infection rates. The problem that I've been reading about in Africa is that condoms are not utilized because they interfere too much in the love making process (ie, takes too long to put them on, and they're too expensive). A prototype device is being introduced here [dezeen.com] to try and address those issues.
Spread of this disease is preventable (which was the GP post's point); efforts to educate and provide the protection would be immediately effective versus waiting for a scientific cure... which would also have to be made available cheaply enough to help impoverished Africa (ie, not for many years after being made available on the market).
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The videos on that site show some keen engineering. It all seems so simple.
Re:How many friends??? (Score:4, Informative)
In Africa it is a common belief that using a condom is "unmanly" and a woman, even a prostitute, that requests it is likely to get a beating. Condom use is a joke in Africa - it isn't going to happen.
What this means is you have infected people running around loose infecting more people constantly. Sure, there are millions of infected people. People that don't understand how the disease is transmitted and are constantly lied to about it. And people that are so completely caught up in the cultural prohibitions about things like condoms and birth control that it will never stop.
Spending money in Africa to control AIDS is like sending food aid to the warlords in Somalia.
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It is far better than hopelessness, but I understand your pain.
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Re: the female condom.
I keep hearing very conflicting reports on the effectivness value of these condoms. some people say they arent as reliable (harder to use effectivly) some people say they are no better than regular condoms. I believe you are the first person I have heard praising them for the quality of sensation.
Do you have any more info on these? testimonials? advice? Ive been OK with regular condoms thus far but if you are telling me these actually provide a superior sensation then it is worth
Unnatural selection (Score:2)
Considering that we've known about 1% of the population is naturally immune to HIV, if we can use these tweaks to increase that percentage by two orders of magnitude...
Goodbye, Darwin. Hello, future.
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Not quite... natural selection will still be at work, but now it will be the folks that have some fundamentalist belief or physical inhibition to having this done to them will be slowly selected out. For instance, I'd put money that if the human race survives a few thousand more years, that antibiotic allergies will be selected out of the gene pool.
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Is the correllary true? That if the human race diminishes we will not have acess to this AIDS technology? The pool will be "closed", so to speak?
Pool's closed (Score:3, Funny)
Humans said goodbye to Darwin years ago (Score:3, Insightful)
Humans have been circumventing Darwin for centuries. The only thing left we don't control are viruses and cancer. And it's not like it's such a bad thing, with the exception of stupid people living so long. Modern society, with it's welfare, social security, laws, birth control, medicine, and safety regulations all fly in the face of natural selection. If you're stupid, we have all these laws and people looking out for you to keep you from doing something stupid and killing youself. If you're lazy, we
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And it is. It's picking those most fit to survive in the current conditions. Current conditions mean you don't need to be fast or strong. It will still select those who are best able to survice under the current presures of the world. Evolution doesnt have a direction or a speed, it's just change to adapt to the world.
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That's not strictly true. Natural selection is survival of the fittest, to reproduce. Once you stop having children, natural selection becomes much weaker, as your contributions to the population is merely ensuring that your children survive and reproduce, en masse. Not much selection against cancer when you're 80.
Even though our society has shifted away from having children to make ends on the farm meet, to investing in the survival of every child s
So, I wonder... why doesn't the body make more? (Score:5, Interesting)
Does this stuff affect other viruses? (Is it something that evolved for this reason?) If so, why doesn't the body make more of it already? Would that be too biologically expensive, or would that have problematic effects we haven't recognized yet?
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A simple answer: (Score:4, Funny)
Does this stuff affect other viruses? (Is it something that evolved for this reason?) If so, why doesn't the body make more of it already? Would that be too biologically expensive, or would that have problematic effects we haven't recognized yet?
Well, it is a miracle drug that cures everything, from deadly viruses, bacterial infections, even cancers. The problem is that VIRIP, or as its know under its commercial name, Trutonin, obliterates the person's immune system... Creating a lifelong dependance on the drug.
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Besides the virus is too young(several human generations age) for us to evolve(and Central Africa would be the first to have evolutionary advantage) more of the anti-virus functions.
Answer lies in the abstract (Score:3, Insightful)
The 1-antitrypsin protein is something there's a lot of in the blood. Its role is prevent one of the body's degrading proteins from breaking down things it shouldn't be breaking down. This 20 residue peptide is just the end bit of the larger protein. The anti-HIV functions are more like a happy side effect of the larger protein's
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Perhaps, but probably not.
"If so, why doesn't the body make more of it already? Would that be too biologically expensive, or would that have problematic effects we haven't recognized yet?"
The reason that we don't have more of it already is that there has been no selective pressure on our genome to produce more of it. That is, we reproduce ourselves well enough without it.
Sythesis (Score:3, Insightful)
Yes, but how effective. Generally, drug companies synthesize naturally occurring compounds (effedrine vs. psuedoeffedrine) to remove nasty side effects and improve performance. However, this systhesis also allows the companies to patent their drug formulations and charge exhorbitant amounts of money for they molecular forgeries. In this case, I wonder how "proved effective" matches up with a two orders of magnitude boost in potency. Everyone needs to see a return on investment, but if there is no reason to make a synthetic version and the (tweaked) naturally occuring version works as well or better, I would hope seeing return on investment is translated as "lives saved" and not "dollars earned."
Anti-HIV virus (Score:2)
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But alas, she still says "roll up your sleeve"...
Vampires already know this (Score:2)
virus mutation (Score:2, Insightful)
Not entirely true (Score:2)
Cure for viruses Generally (Score:2)
While AIDS is horrible and we all hope for a cure, I would like to see a more generalized anti-viral approach that would cure viral disease universally. Hopefully all the research expended on AIDS will have some cross-over applications.
Re:Cure for viruses Generally (Score:5, Informative)
Imagine a wall with hundreds of doors on it, each with a different type of lock. Viruses are like burglars trying to break in, but they each only know how to pick one kind of lock. This type of treatment will result in blocking only the doors that have the same type of lock that HIV uses. Hepatitis, for example, would use a very different lock (different wall actually).
Or, since this is slashdot, you could also look at it as a host's firewall. HIV may attack a specific port, and this treatment may block only that port.
This is a very simplistic way of explaining it, but for the most part, this type of treatment only has an effect on HIV's specific attack characteristics. Viruses are usually very particular about what types of cells they attack, and then it can get even more specific. I'd view this as a specific fix.
Now, where things can start to get interesting is if they can manage to generalize this approach to find the appropriate blocking peptides for other types of viruses. If the approach can be generalized, then you might be able to find treatments for other viruses, but the hope for a universal cure for viruses isn't very feasible.
Viruses hijack our own internal machinery to reproduce themselves, so you can't exactly target them the same way that you can bacteria. (There are some common points that are being used to target specific classes of viruses, but I'm not aware of any universal point of attack). You can pretty much target viruses are three points: 1) at the point of infection into the host cell, 2) replication of the virus, 3) at the point where the daughter viruses leave the host cell. The approach mentioned in the article is of type 1.
Maybe we've been here before... (Score:2)
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That sounds to me like maybe humans, or apes, have faced something like this before and still have low-level semi-functional stuff in place to deal with it, and in a couple generations the descendents of people with the best expression of this would become tolerant or immune to HIV.
You're right. And some of the genes that confer resistance to AIDS are more than semi-functional. For example, in areas of the world where the Black Plague was common (Europe and Central Asia) 12%-14% of the population ha
It reads like this on Etherealworld Slashdot (Score:3, Funny)
really? (Score:2)
Not mine.
What's that word, again? (Score:2)
But that's pretty damn cool:) Here's to hoping it actually works and makes it to market.
Before you go out celebrating (Score:5, Insightful)
The "cocktail" that's currently used to treat HIV infection drugs to prevent HIV from entering cells, drugs to keep it from reproducing inside cells, and drugs to keep it from breaking out of infected cells. From what I read in the summary, this new treatment fits in that first category. Good thing, because HIV has this nasty tendency to mutate and become immune to any given drug after years and years of use. When that happens, the patient has no choice but to switch over to another combination of drugs, probably more expensive, and probably not as friendly to the body. If this "blood-derived" treatment adds to the list of patient-friendly treatments available, that's fantastic.
But the way I read this, it isn't the magic bullet "cure for AIDS" everyone is wishing for. It can slow down the progress of an infection, but reversing that progress is another matter altogether. Ditto for undoing damage to the immune system.
The real cure... (Score:4, Funny)
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Re:Proof is in the pudding... (Score:4, Funny)
OberGrammarFuehrer von Umlaut at your service!
/clicks heels
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That depends on the situation. What if someone put the smoking gun in the pudding?
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C//
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not a disease i.e; you end up prone to infection by any random pathogen you are exposed to.
It sounds like this protein inhibits viral infection, with no indication as to whether or not
it can wipe-out an existing infection: If you no T-cells left it's of little benefit to have
something which prevents them from being killed.
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Im no medical expert but if all of the HIV virus in your system was wrapped in these proteins and some of those bits of warped virus got into someone else, they wouldn't be able to infect cells in the new host and thus would not be able to replicate.
But like I said, im not an expert.