Stem Cell Research Paper Recalled 112
MattSparkes writes "One of the best-known stem cell papers describes adult cells that seemed to hold the same promise as embryonic stem cells. Now some of the data contained within the paper is being questioned, after staff at a consumer science magazine noticed errors. It shows how even peer-reviewed papers can sometimes 'slip through the net' and get to publication with inaccurate data."
indeed. (Score:5, Funny)
Yes, I remember it quite vividly myself.
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Total Recall
Sounds familiar! (Score:5, Funny)
Print media with a clue? (Score:2)
I'm hoping it wasn't the doctor from India who does the floors at night.
No shit sherlock. (Score:5, Informative)
Of course (Score:5, Interesting)
Anyone who's read a significant number of journal articles has spotted some huge errors that somehow got published. I know of one paper (not naming any names!) where in explaining how a calculation was done it had the line: 18-7=9. Clearly (from context) the line meant to say 17-8=9, but I found it humorous that such a fundamental error got past both the original authors proof-reading and the peer-review process. These things go back and forth a couple times, usually.
Peer review isn't a perfect process. It just helps reduce the noise-to-signal ratio.
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To me, the fact that they wasted space printing 18-7=9 is more shocking than the actual error.
Re:Of course (Score:5, Insightful)
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Probably the mistake of the publisher (Score:2)
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Not sure I see the similarity (Score:2)
The authors are friends of mine, the math mistake has no impact on the conclusions of the paper, and it's not really that unusual of an event (as witnessed by other comments on this thread). I hardly think having a math mistake in a paper is anything like screwing over a customer. Nor am I trying to enhance their ability to make further math mistakes. Maybe you're just being sarcastic, in which case, never mind.
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Dean
Peer review and copy editing (Score:2)
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It's less humorous when it happens to you. It's never happened to me, but a colleague was once in quite a state when an article was published that he was lead author on and figures 2 and 3 were identical. Both were the original figure 2. It had happened in the original MS--somehow the same graph was included twice. The caption was right, the discussion in the text was right, bu
Data says whatever you want it to (Score:4, Funny)
Re:Data says whatever you want it to (Score:5, Funny)
There, fixed it for you.
Re:Data says whatever you want it to (Score:5, Funny)
You have failed peer review.
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I'm not sure if that's a defence of slashdot's moderation/threading system, or if it's an attack on science as it stands today.
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Uh yeah, definitely.
Peer review is what it is, review by peers. The problem only shows up when people start acting like peer review is a stamp of authenticity or correctness, when in reality it is neither and can be neither.
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There, fixed it for you.
Re: off topic but (Score:2, Funny)
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Much of peer review involves checking the form, rather than the substance, of the paper. Does the paper follow proper protocal? Is it clearly written? Are the references complete and correct? Should it be shortened or added to?
The substance of the paper also comes into it, of course, but the reviewer is very limited as to what he or sh
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Gosh, that reminds me of a scene in the original five-book Foundation Trilogy: "...Why not go to Arcturus and study the remains for yourself?" Lord Dorwin raised his eyebrows and took a pinch of snuff hurriedly. "Why, whatevah foah, my deah fellow?" "To get the information firsthand, of course." "But wheahs the necessity? It seems an
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Dean
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You should, perhaps, try peer reviewing a paper yourself to understand the position reviewers are in, and what peer review means in practice.
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You beat me to it. A lot of journals only use 1 or 2 reviewers. 3 is the most I've ever heard of. Reviewers are neither paid for their work nor given a lot of time to do it, so some really just phone it in. Even the more thorough ones: we're talking essentially 3 chances to find a mistake. I've rievewed papers and if I notice a mistake I'll certa
Peer review is self correcting (Score:5, Informative)
Yes, the process can take time, and god forbid you were the poor grad student that spend 3 years heading down a blind alley, but this episode just reaffirms that overall, the process works.
Re:Peer review is self correcting (Score:5, Insightful)
This is how scientific consensus is important. In a "yup, I checked it, I got the same thing" way, not in a let's-vote-like-we're-voting-for-congress way.
Re:Peer review is self correcting (Score:5, Insightful)
This difference in priorities is what causes such a disconnect between the science and non science communities, and in fact is one of the greatest challenges in teaching science. The public or the students wants to simply know "the answer", whereas the scientist is more concerned with how the answer was realized, and with which other problems such a process might help. it is also the argument between science and some fundamentalist religious folks. The later are say "god is the answer", the former is saying "science is the solution", neither necessarily talking about the same thing, but niether cognizant enough of the differences to intelligently diffuse the debate.
Supposed to, but often doesn't (Score:3, Informative)
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Sexy science, bad science (Score:5, Interesting)
And ... (Score:1)
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The biggest argument for adult stem cells is that the differention is a good thing. EG, you really don't want cells that might decide to make tooth or bone when you're trying to repair a nerve.
Not quite. (Score:5, Insightful)
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Cannot see the Future (Score:1)
Oblig. Futurama (Score:4, Funny)
Stem Cell Clinic Worker: Well, yes, in the same way that an infant may fight Muhammad Ali, but....
Prof. Farnsworth: (slapping down $300 Tricky Dick Fun Bill) One pound of stem cells, please!
(Prof. Farnsworth begins slathering the stem cells all over his face.)
Stem Cell Clinic Worker: Of course, any age-reversing effects will be purely temporary--euuugh!
Journals want to make make money (Score:5, Insightful)
Nature != popular science journal (Score:4, Insightful)
There is certainly a bias in both Nature and Science towards novel, groundbreaking research, along with an emphasis on sexy (nanotechnology and stem cells are very hot right now, so the threshold to publish these papers has dropped). This does not have anything to do with the quality of science in the papers that are published - I challenge you to find an article in either Nature or Science that has "clear problems" in the science presented.
As someone mentioned previously, peer-review checks for a correlation between the conclusions and the data they are drawn from; it is not meant to verify results prior to publication. You, sir, are talking out of your ass.
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Too bad you are an AC that probably will never get enough mod points for this to see the light of day.
Mod parent up, GP down (Score:2)
MOD UP! (Score:1)
Nature and Science are not popular rags.
Dean
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There is certainly a bias in both Nature and Science towards novel, groundbreaking research, along with an emphasis on sexy (nanotechnology and stem cells are very hot right now, so the threshold to publish these papers has dropped). This does not have anything to do with the quality of science in the papers that are published - I challenge you to find an article in either Nature or Science that has "clear problems" in the science presented.
Challenge accepted.
No. Nature and Science and not sold on newsstands. Both journals cost a fair amount and are usually only purchased by libraries and members of the scientific community. I called them popular, because they are read by members of all scientific disciplines and are widely known. Anyways, the majority of papers that these journals publish are some of the best works in science. If a scientist has only a few papers published in either journal in their career, they will have done well. I am
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Publishers: What, see the paper BEFORE it goes to press? But, but, how are we going to rip you^H^H^H^H^H^H^H do our hard work and provide our valuable service? You must pay $35 for that 780k PDF, we've put a lot of work into getting it to you!
Sarcasm aside, I agree with you. Greedy publishers don't belong in science anymore. The articles want to be free!
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Yes, anywhere from 6 to 24 months after publication for most of them - which can be a lifetime in some fields.
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Here is a free clue for you: There are highly-respected journals that give away all their content for free on the web for anyone to read. They still use anonymous reviewers. The use of anonymous reviewers has nothing to do with greed or a desire to keep knowledge bottled up.
Yes, anywhere from 6 to 24 months after publication for most of them - which can be a lifetime in some fields.
Let me try this again. There are highly-respected journals that give away all their content for free on the web for anyone to read before, during, and after the time that the hard copy is printed. They still use anonymous reviewers. The use of anonymous reviewers has nothing to do with greed or a desire to keep knowledge bottled up.
Don't believe me? Take a look at http://jmlr.csail.mit.edu/ [mit.edu] and http://www.jair.org/ [jair.org]
Now you know. Please stop confusing the issue.
Dean
not just "sometimes" (Score:3, Informative)
It shows how even peer-reviewed papers can sometimes 'slip through the net' and get to publication with inaccurate data."
How about the misandry-filled assertations about how women use more words than men, have brains more "wired" for communication, etc? Turns out that everyone's been quoting each other and nobody can even stick to facts interview to interview [boston.com].
What's appalling is that the author, Dr. Brizendine, not only holds a top academic position, but also has a best selling book that is full of "facts" that are complete fabrications.
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What you say are true. Man use just many words as woman. Me go watch football now.
So this means... (Score:1, Insightful)
I really hope they can advance this area of study, I would hate to think that we use human embryos to solve other human's problems just because it was harder to do it with adult stem cells.
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Yes, yes, I know that your beliefs ask that we not destroy viable embryos. That's fine, I'm just responding to your misuse of language.
Stem Cell Research Paper Recalled... (Score:5, Funny)
Re: Stem Cell Research Paper Recalled... (Score:5, Funny)
Given the political context that should read, "...when it was learned that it contains small parts of children under three."
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Re:How about re-devolution of cells or re-embryoni (Score:1)
basic screw-ups in peer review (Score:1)
This is unexpected? (Score:4, Interesting)
Another one published in a prestigious journal and with a few million in government backing found 100+ genes that were significantly linked to cancer. The statistics was the type that anyone who has taken even a couple courses could find flaws in. So someone redid the analysis and found ~8 such genes at best and possibly fewer. Due to the profile of this one the proper analysis is being done as a follow-up with the original researchers help (otherwise the flaws would have been much harder to identify).
So yeah, published papers can and do have flaws but they usually they get caught after a while, the point of publishing in some ways. At the same time more researchers should release their data so it can be verified more accurately (this has its own problems as if too many people run too many methods on the same data there will be spurious results of one sort or another).
And so THIS statement is the right one. . ? (Score:2)
There is just WAY too much money invested in the current trajectory of the Cancer/Stem-cell research and medicine behemoth to let some upstart new ideas about curing people easily get in the way of the billions of dollars currently flowing.
Remember how Exon Mobile has been deliberately muddying the waters with regar
Re:Talk about stem cells... (Score:4, Informative)
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I know New Scientist is "just" a consumer science magazine, but such publications can play an important role. Scientists, being human (mostly) are also prone to human failings, and even a lowly consumer science mag can point them out.
Traitors should leave first (Score:1)
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Republicans may be guilty of this, but don't be fooled into thinking the Democrats, or any other political party for that matter, are innocent.
And those are some ridiculously arbitrary dates you chose. The US was practically founded on the idea that our side was right because it was our side, and if you can think of any war in record that didn't have that as the cause, one way or another, you probably just haven't looked into it enough. It's practically the human conditio
Re:Somebody should tell the king... (Score:4, Insightful)
Both sides are wrong. There, does that make you feel better? It isn't the sides that are the problem. It is that there are sides.
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See, people like you trolling a debate they know nothing about would make me ashamed to be an American (if I was one). Here's a hint: this story is talking about adult stem cells, which has no significance at all in regard to the current political/moral question of embryonic stem cells. They're two totally different things, obtained through totally different processes.
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Come on - he SAID he was American. You expect him to have a clue?
Oh I am burning Karma tonight, hehehe. Please, feed the trolls!
Re:Somebody should tell the king... (Score:5, Informative)
people like you trolling a debate they know nothing about would make me ashamed to be an American (if I was one). Here's a hint: this story is talking about adult stem cells, which has no significance at all in regard to the current political/moral question of embryonic stem cells.
Actually, they are completely relevant to the moral/political question of embryonic stem cells, in so far as embryonic stem cell opponents have been using these adult stem cells to have their cake and eat it too.
Specifically, they've been tying the hands of researchers due to their religious beliefs and then shielding themselves from criticism by claiming "oh, we don't need embryonic cells anyway, because adult stem cells are just as good." Here is one example [nationalreview.com].
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[1] It should be noted that adult stem cells have already proven extremely useful in treating many diseases, whereas embyonic stem cells have proven useful in treating exactly zero so far.
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Of course, this would mean destroying several embryos in order to treat the patient. And no, I don't see that as ethically justifiable.
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