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Science

Scientist Says Most Scientific Papers Are Wrong 656

An anonymous reader writes "According to epidemiologist John Ioannidis, the majority of published scientific papers are wrong. If Ioannidis's own paper is right, a randomly chosen scientific paper has less than a 50% chance of being true. He also says that many papers may only be accurate measures of the prevailing bias among scientists. However, a senior editor of a scientific journal says that scientists are already aware of this: 'When I read the literature, I'm not reading it to find proof like a textbook. I'm reading to get ideas. So even if something is wrong with the paper, if they have the kernel of a novel idea, that's something to think about.'"
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Scientist Says Most Scientific Papers Are Wrong

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  • groan (Score:3, Funny)

    by grub ( 11606 ) <slashdot@grub.net> on Tuesday August 30, 2005 @05:38PM (#13440089) Homepage Journal

    Great... watch the Creationist/Intelligent Design kooks run with this.
    "See? Scientists don't know what they're doing! All your answers are in Teh Bile-Balllllllll! Praise JEEEEEEE-zussssssssss!"
    • Re:groan (Score:4, Insightful)

      by geomon ( 78680 ) on Tuesday August 30, 2005 @05:40PM (#13440122) Homepage Journal
      "See? Scientists don't know what they're doing! All your answers are in Teh Bile-Balllllllll! Praise JEEEEEEE-zussssssssss!"

      Yes, but unlike religious dogma, scientific theories are meant to be falsifiable.

      Unless someone in the ID camp is willing to admit that God is falsifiable, their theory will not be considered science.
      • Re:groan (Score:2, Insightful)

        by grub ( 11606 )

        In ~10 years of trying to find scientific evidence of just a single god the ID people haven't published a single paper. So now they attack the school system when their original mission (evidence) has failed.
        • Re:groan (Score:5, Insightful)

          by syzler ( 748241 ) <david@s[ ]ek.net ['yzd' in gap]> on Tuesday August 30, 2005 @07:26PM (#13440987)
          After reading the summary, I was under the impression that this artical was about a high rate misleading papers published by scientists.

          Based on all of the anti-creationalist comments I thought maybe I had misread the summary, so I looked at the article itself.

          Not once did I see mention of the universe's creation in the summary or in the linked artical, in fact the example stated was "such as whether a particular gene influences a particular disease."

          It seems to me that lately a lot of comments on slashdot have been trying to start a witch hunt for advocates of ID. Can we please knock it off and stop screaming wolf every time some thing that is related to science is mentioned on slashdot.

          • Re:groan (Score:5, Funny)

            by Kohath ( 38547 ) on Tuesday August 30, 2005 @08:33PM (#13441660)
            It seems to me that lately a lot of comments on slashdot have been trying to start a witch hunt for advocates of ID. Can we please knock it off and stop screaming wolf every time some thing that is related to science is mentioned on slashdot.

            You realize you're talking to zealots, right? I don't think "please" is going to cover it.
        • by edremy ( 36408 ) on Tuesday August 30, 2005 @08:02PM (#13441384) Journal
          Stephen Meyer got an ID paper published in the peer-reviewed Proceedings of the Biological Society of Washington last year.

          Skeptic had their take on it in the last issue. In a nutshell

          • The journal is in the bottom 20% of all journals for impact, but it is a legit peer-reviewed journal with a long history
          • The current head editor is a noted creationist who's on the editorial board of another journal that only publishes papers that are in agreement with a literal interpretation of Genesis.
          • The editor won't say who the reviewers were, only that they were biologists at well known institutions.
          • The paper's sponsoring society was not happy, and put out a press release saying that none of them would have agreed to publish if they had known.
      • Re:groan (Score:4, Informative)

        by david.given ( 6740 ) <dg@cowlark.com> on Tuesday August 30, 2005 @05:55PM (#13440266) Homepage Journal
        Unless someone in the ID camp is willing to admit that God is falsifiable, their theory will not be considered science.

        God's irrelevant to whether ID is true or not --- it's whether ID is falsifiable or not that's important.

        Which, AFAICT, it isn't, so it's still not science. But let's at least be precise when slagging them off...

      • You miss the point (Score:3, Insightful)

        by tjstork ( 137384 )
        The real point is, in the eyes of the common man, science is a brand of information, just like Walmart is a brand for stores or Nike is a brand for shoes, and the brand is taking a beating.

        Here's the attitude.

        "you want someone to believe human origins from a set of people that told me I would die if I smoked and ate a cheeseburger and I'm still living."

        "well now basically you are just making up evolution to fit your story together. Well I can do that too. Can't test it either way, can we..."
      • by Shivetya ( 243324 ) on Tuesday August 30, 2005 @07:22PM (#13440958) Homepage Journal
        the level of religous dogma in some camps.

        The only question is, who decides which science is wrong? I doubt very seriously any big money areas will have a published high rate of error. After the high money science the next protected type would be whatever is en vogue for the time.

        Scientific integrity took a big dive in the late 80s as special interest groups suddenly realized that marketing, confusion, and intimidation were far better at advancing agenda than honest science.
      • Re:groan (Score:3, Funny)

        by fbg111 ( 529550 )
        Unless someone in the ID camp is willing to admit that God is falsifiable, their theory will not be considered science.

        Ah, but they don't actually need to admit such a thing, because the Babel fish is a dead giveaway, isn't it? It could not have evolved by chance. It proves God exists, so therefore, by ID/Creationists' own arguements, God doesn't. QED.
    • Re:groan (Score:3, Funny)

      by ugmoe ( 776194 )
      While some scientists are claiming that intelligent design should not be taught because some religious people believe in it, other scientists are actually having difficulty determining if a particular plant is naturally occurring, whether it was created, or whether it is a cross between a naturally occurring plant and a human-created plant.

      http://www.newscientist.com/channel/life/gm-food/d n7729 [newscientist.com]

      Researchers at the Centre for Ecology and Hydrology in Dorset, UK, tested the herbicide glufosinate ammonium

      • Re:groan (Score:4, Insightful)

        by Moofie ( 22272 ) <leeNO@SPAMringofsaturn.com> on Tuesday August 30, 2005 @06:21PM (#13440487) Homepage
        I don't dispute for a moment that intelligence can create new forms of life.

        I do dispute the scientific validity of the claim that ONLY intelligence can create new forms of life.

        Your straw man is now on fire.
      • Re: groan (Score:4, Insightful)

        by Black Parrot ( 19622 ) on Tuesday August 30, 2005 @06:30PM (#13440561)


        [snip irrelevant bullshit]

        > Why would anyone want to close their eyes and cover their ears and say "I can't hear you - there is only evolution - there is no intelligent design - I'm not listening to you"? When actual real scientists are creating organisms which other scientists cannot distinguish from similar species found in nature?

        I don't see anyone applying ID methodologies to determine whether this plant is the result of intelligent design or not. Any idea why?

    • It took them 100 years but they spinned creationism into ID, in 100 years they'll come around. Evolution has always been evolution, their side twists and spins. The truth will always be right.
    • Re:groan (Score:3, Insightful)

      by emh203 ( 815620 )
      It's amazing to see the bias here. A paper is written about how a lot of other research is wrong, and people automatically start associating it to the ID community. Come on, this does nothing for the progression of the search for the truth.

      Realistically, I have been through grad school with a REAL science degree. I now work as a researcher at Penn State University. Even though I am not promoting wierdo pseudo-science, I am not to impressed with the scientific community as well. They pull some of the sam
  • by geomon ( 78680 ) on Tuesday August 30, 2005 @05:38PM (#13440090) Homepage Journal
    Wow! Science can be wrong.

    That is how the system works.

    But just because these two scientists were wrong about the precise mechanics of evolution doesn't mean that they were wrong about how the data should be interpreted. The data shows that life has progressed to meet the demands of its environment. Survival of the fittest is correct, but there is no straight-line progression of lifeforms leading one from another as was supposed when these authors first penned their ideas.

    Scientific ideas may come and go, but the data set just gets larger. That is why this guy can claim the others are wrong: he has a better data set.
    • by superyanthrax ( 835242 ) on Tuesday August 30, 2005 @05:43PM (#13440154)
      It is well known that science can be wrong. For example, before about 1900 the model of the universe was based on Galilean relativity, which was proven wrong by Einstein and friends. Those results were based on well-conceived and performed experiments, all of which confirmed their hypothesis (b/c they couldn't get close to light-speed so they couldn't tell).

      But if the creationists/intelligent design advocates/Christian fundamentalists want to use this to say that they're right, they're relying on a logical fallacy. Just because a few papers are wrong doesn't mean that their view is correct. Their view of creationism is not the only alternative to the view of evolution present in a few possibly flawed papers. Evolution may work in a way that we aren't sure about, but this doesn't prove that intelligent design is correct.
      • by jc42 ( 318812 ) on Tuesday August 30, 2005 @10:52PM (#13442647) Homepage Journal
        ... Galilean relativity, which was proven wrong by Einstein and friends.

        Actually, strictly speaking, Einstein (and friends) didn't prove Galileo or anyone else wrong. That had already been done by others. Thus, precise measurements of the orbit of Mercury and turned up discrepancies with Newton's and others' laws of orbital mechanics. The Michaelson-Morley experiments produced the apparently-absurd result that light moved at the same speed relative to all observers, even if those observers were moving relative to each other or the light source. Etc.

        What Einstein did was develop a new theoretic approach that could explain a number of these anomalies. It was then up to the scientific community to viciously attack Einstein's theories, and attempt to prove him wrong. They've been at this for a century now, and all of their tests so far have end up with results consistent with Einstein's theories, to within the error bounds of the measurements. In scientific circles, this constitutes "proof" that Einstein's theories are either correct, or are very close to correct.

        Even then, the earlier theories hadn't really been proven wrong. Rather, they were shown to be merely good approximations. After all, if your instruments can measure something to 12 places, but Einstein's and Newton's equations predict a difference in the 20th place, you can't show either set of equations to be wrong. This is why those earlier "disproved" theories are still taught in science and engineering schools. Newton's equations are a lot simpler than Einstein's, and in situations where you can't measure the difference, you might as well use the simplest equations. You just have to be careful not to apply the simpler equations in situations where they aren't good enough.

        But note that Einstein himself didn't disprove those earlier theories; that had been done by the others that found the anomalies. And Einstein didn't prove his own theories; that has been done by a century of tests by the entire scientific community. He did the really hard job: He came up with his wild new theories of a universe that behaved rather differently than anyone thought. But his theories were consistent with those strange observations. And his theories included equations that could be tested against the real universe. And his theories keep passing every test that anyone comes up with.

        Now if we could get some other would-be scientists to present us with versions of their theories that can be tested against the real universe ...

    • So true! One of the biggest reasons scientists publish formal papers is so that other scientists can study and attempt to corrobotate -- or disprove -- the results of the paper.
      • by Dausha ( 546002 ) on Tuesday August 30, 2005 @07:23PM (#13440965) Homepage
        Scientists publish papers to get tenure and paid.
        • by xtal ( 49134 ) on Tuesday August 30, 2005 @09:43PM (#13442178)
          Universities have failed a lot of scientists in that a) those papers are the result of stupid tenure policies and b) universities often do little to promote their researchers.

          Engineers often read papers to solve problems. When they know about them! (Google Scholar might fix this)

          A worse problem than them often being wrong is that:

          a) there is frequently no way to determine if a given paper is accurate, has mistakes, is partially accurate, is laughable, was accurate at one point but is outdated, etc etc. At least from an outsider's perspective.

          b) there is no good way to stay abreast of current interesting developments - hell, there's no way to see interesting things from 20 years ago easily! Again, this is from an interested outsider's perspective.

          Once or twice a year I have the luxury of spending a week or two in an engineering library for the express purpose of finding out new and interesting things in my field. I'm SHOCKED at the amount of material that is being duplicated (often badly) in industry, material that is inaccurate or poor quality, and VERY GOOD material that never sees the light of day again.
          • Even in the journals that I regularly read (every issue, every year), I only read a relative handful of papers, germaine to my research. When my research topics evolve, I might go back and read different papers in the same issue. Maybe there are some scientists out there who read every paper in every issue of journal in their field, but they must read a hell of a lot faster than I do. I rely on Current Contents, automated lit searches, and other computer-based tools to sift through the flood of info. I also
    • by erice ( 13380 ) on Tuesday August 30, 2005 @06:17PM (#13440455) Homepage
      Science progresses when well thought out hypothothies based on a good data are replaced by more inciteful reasoning based on more complete data. Lamarck wasn't guilty of faulty reasoning. He just didn't have a complete enough data set.

      But the article at hand, isn't talking about that kind of "wrong". He is talking about conclusions that can not be supported by the data presented. Either the reasoning is faulty or the data collection methods are so faulty that no meaningful conclusions can be drawn.

      When a theory is proven wrong in the scientific sense, it is a good thing. We learn something new and that be the basis for further developments. But if a theory is proven "wrong" in the mechanical sense, we have no new insights, just a relief from further time wasting.
  • Well (Score:4, Funny)

    by Neil Blender ( 555885 ) <neilblender@gmail.com> on Tuesday August 30, 2005 @05:39PM (#13440095)
    Their is a 50% chance that that's not true.
    • Re:Well (Score:3, Insightful)

      by corngrower ( 738661 )
      I wonder how many papers in mathematics he reviewed in his study. Many of them are incomprehensible to anyone who is not working in topic covered by the papers. I doubt you'ld be able to classify them as 'true' or 'false' in the same sense you might classify some biological research or some medical research. If a mathematics paper has been published in a well respected, peer reviewed journal, there's a pretty good chance it's true. (but not 100%)
  • by turtled ( 845180 ) on Tuesday August 30, 2005 @05:39PM (#13440099)
    Scientist Says Most Scientific Papers Are Wrong

    I can't believe it!
  • Blinded by Science (Score:5, Insightful)

    by Jhon ( 241832 ) * on Tuesday August 30, 2005 @05:39PM (#13440108) Homepage Journal
    "Science" is NOT the same as "fact" or "truth". It is a METHOD -- a PROCEDURE one follows in an attempt explain some event or phenomenon. It should hardly be surprising that "Scientific" papers are mostly wrong. There may be only one "right" or "correct" theory for a given phenomenon -- but there are countless wrong ones.
    • by blamanj ( 253811 ) on Tuesday August 30, 2005 @06:15PM (#13440436)
      And, as the article mentions (but doesn't go into detail on), this is why reproducibility is so important.

      Let's say a scientist comes up with a new idea, does the research, and publishes a result. OK, assuming we buy the article's premise, there's a 0.5 chance s/he's made a mistake. Now another scientist and then a third duplicate the experiment and get the same result. The odds that the original proposition is in error drops to 0.25, then to 0.125. The odds are now 8:1 the result is valid.

      See cold fusion for an example of the converse.
  • by autopr0n ( 534291 ) on Tuesday August 30, 2005 @05:39PM (#13440109) Homepage Journal
    Not too surprising.

    I wish people would be a little more weary of automatically believing everything they read in a scientific paper, or worse a crap article from a journalist who doesn't even understand the paper in the first place.
  • by fembots ( 753724 ) on Tuesday August 30, 2005 @05:39PM (#13440112) Homepage
    Wow, I thought Study Shows One Third of All Studies Are Nonsense [slashdot.org] is bad enough, who knows scientific papers are worse!

    I patiently await the next article: "Research Shows Three-Quarters of All Researches Are Bullshit".
  • Most wrong? (Score:3, Informative)

    by Spy der Mann ( 805235 ) <spydermann.slash ... com minus distro> on Tuesday August 30, 2005 @05:40PM (#13440121) Homepage Journal
    Gee, i didn't know most of "IEEE transactions on Image Processing", "Journal of Algorithms" or "IEEE Transactions on Pattern Analysis and Machine Intelligence" were probably wrong.

    Please be more specific next time. Thank you.
    • Although those journals are better than average, they, too, contain a high percentage of papers that are wrong. They aren't usually wrong in the blatantly obvious math-is-incorrect way, but they are often wrong in the interpretation of their results, or their experimental procedure. PAMI, for example, publishes many papers that contain benchmarks that are claimed by the paper to show that one method is better than existing methods but fail to do so.

      If you think papers in those journals are mostly correct,
      • Re:Most wrong? (Score:4, Interesting)

        by Spy der Mann ( 805235 ) <spydermann.slash ... com minus distro> on Tuesday August 30, 2005 @06:19PM (#13440470) Homepage Journal
        Well yes, for the scientific community it's common knowledge (at least IMHO) that these papers are HARD to prove wrong, most are assumed true, but then again, what I learned most about image processing was in these papers. They do contain very valuable information, and a lot of these are works based upon previous works. (This is how science is done right now).

        Even when some of these papers could be wrong in their conclusions, or maybe one or two algorithm flaws, but it was papers like these (image processing, etc) that contributed to technology used today, like MPEG4 video.

        My point is, unlike these which are done with scientific methodology, in *medical* "research papers" there's oh so much money at stake. I'm sure the article could have said "most medicine research papers are wrong", and I would have believed that.

        But science is much more than medicine, and as a scientist, I find it an insult to stain the name of Science because of commercial vias in medical research.

        Curiously, I googled for "bias in medical research" (with quotes) and here's the top result, of 426 search results:
        Bias in Medical Research [suite101.com] by Maria Spicer.

        In contrast, googling for "bias in image processing research" (with quotes) yielded no results.

        Of course, google is only a very statistical method for finding out whether something exists or not, but I think you get my point.
  • That's probably because most scientific papers are put out to be peer reviewed. Most of them most likely do not pass that test, or at the least, are redundant.
  • Does this mean that peer review fails as a method to filter out time-wasting, tree-killing dreck?

    Does it also mean that unpublished scientific papers are right 50% of the time?

    • Re: Peer Review (Score:4, Interesting)

      by Black Parrot ( 19622 ) on Tuesday August 30, 2005 @05:59PM (#13440305)


      > Does this mean that peer review fails as a method to filter out time-wasting, tree-killing dreck?

      Peer review isn't a certification of correctness. It's just supposed to filter out the papers where the authors didn't do their homework. It can spot bad logic, use of outdated data, failure to consult important papers in the field, etc. But it can't tell us whether string theory is correct or not.

    • Re: Peer review (Score:5, Insightful)

      by poszi ( 698272 ) on Tuesday August 30, 2005 @06:02PM (#13440332)
      I didn't read the article but I don't believe the conclusions of the summary. Maybe in epidemiology it is true but not in physics where usually the results are reproducible and I very rarely find papers that are just wrong. I might agree that most of the papers are not 100% right (small mistakes in formulas happen quite frequently) but it does not impair the usability of a paper.

      However, peer review does not solve all the problems. Most of the research takes a lot of time and effort and referees just read the papers. They do not reproduce the experiments or calculations. So peer review can weed out only obviously bad papers but not papers that looks OK but are wrong.
    • Re:Peer Review (Score:4, Informative)

      by LurkerXXX ( 667952 ) on Tuesday August 30, 2005 @06:10PM (#13440397)
      The article is about "Published Research Findings". It doesn't specify that all the papers analyzed were from peer reviewed journals. There are a lot of non peer reviewed journals out there. Usually you only publish in those if you have a short paper, or one that's not extremely novel, or just not of great general interest. Many times researchers will publish in those journals when they can't get the paper published in a peer reviewed journal. I'm sure the percentage of false findings in those journals is much higher, and may have altered the ratio of found false papers significantly.
  • I thought 33% of the papers were wrong.... Then or this has 33% chance of being wrong, or the other has 50% chance of being wrong....

    Can someone calculate, based on above, a better estimate on the chance of some paper being wrong? :-)

    note: don't publish this calculation on a paper, otherwise it will be subject to these probabilities and we'll have to recalculate all over again....
  • Sadly True (Score:4, Interesting)

    by MindStalker ( 22827 ) <mindstalker AT gmail DOT com> on Tuesday August 30, 2005 @05:44PM (#13440160) Journal
    I have found this to be sadly true. My coworkers are college professors who often publish papers on social trends using large datasets obtained from government records. I am frequently pointing out errors in their analysis (mainly that they simply don't look at their data, such as just because Jane Doe and John Doe have the SSN they are assumed to be the same person) but I'm generally ignored or told to fix it myself though that isn't my job. They are more interested in getting something published and don't want to have to retract something.
  • by FireFlie ( 850716 ) * on Tuesday August 30, 2005 @05:44PM (#13440165)
    I tend to agree with the findings simply because of the inordinate amount of bad scientific papers that I have read. I have also found this to be more true in the field of psychology than most others (I would say more than 50% are bad which brings up the average for all sciences), but that is entirely beside the point.

    What I do see as harmful is the attitude towards bad papers. To many academics try to accumulate more and more published papers the same way that slash-dotters try to build up karma. I understand that having papers published can reflect well on someone, but we need more accountability. Journals need to create a more strict system for reviewing papers that are to be published to weed out more of the crap plain and simple. If the evidence does not reflect the claims throw it away. If the research was conducted on a population that was too small or specific for a grand generalized claim about the topic as a whole, throw it out.

    I understand that you will always have people just trying to throw their names around, but this needs to be looked at from the grander perspective.

    "When I read the literature, I'm not reading it to find proof like a textbook.

    Sure there are probably many scientists that think of it this way. But the problem is that bad research (or a bad paper) rarely dies after being published. They are often cited as evidence for years to come in other papers until enough evidence to the contrary comes out to raise questions. Plus, you have crazy professors giving this bad research for their classes to read, and often they don't explain to their classes where research is possibly flawed--so we find ourselves training generations of new scientific minds that run around spouting out bad research. I understand that we all need to take research with a grain of salt when we read it, however bad scientists trying to become famous with their bad ideas or bad papers can be very detrimental to any field.

    • by Arker ( 91948 ) on Tuesday August 30, 2005 @05:55PM (#13440263) Homepage

      All that is true. But you left out possibly the worst effect of false papers - the effect they can have on the funding gatekeepers. A handful of just BAD research papers, all claiming to show what those that hold the pursestrings want to hear, and suddenly that false conclusion is a 'scientific fact' and anyone that wants their studies to be funded in the future had damn well better agree with that. Which becomes a self-perpetuating cycle.

    • by BenjyD ( 316700 ) on Tuesday August 30, 2005 @06:06PM (#13440357)
      It's not just psychology that has so much publication list padding. During my PhD I was asked to do a detailed review of about ten papers in my area (process scheduling algorithms). They were all peer-reviewed and published in reputable journals by well-known researchers. IIRC:

      - About half had very little novel content. Maybe one equation changed, a few different examples added
      - Two or three had basic mathematical errors
      - About half omitted details that were required to easily replicate their results or actually use their methods. I spent weeks piecing together what the authors meant from various clues scattered across appendices, tables and figures.
      - Several had gaping holes in the method that were apparent to me, a first year PhD with no experience.
      - All of them cherry-picked examples to show their methods in the best light, completely omitting any bad results.
  • If the researcher is Derek Smart, then there is a chance the research ITSELF isn't just wrong,/i>, it DOESN'T EXIST!

    http://en.wikipedia.org/wiki/Derek_Smart [wikipedia.org]
  • Comment removed (Score:5, Insightful)

    by account_deleted ( 4530225 ) on Tuesday August 30, 2005 @05:46PM (#13440189)
    Comment removed based on user account deletion
    • What you say is very true. I am working towards my Ph.D. right now in Physics, and I encounter this every day.

      I think both you and the poster hit on something very important here. First is that we (as people who are reading the research papers) are not looking for proof, etc. of something. When I grab the latest paper on a topic I work on, I am not going to read it and say, "Oh. They found x which contradicts with what I am seeing. They must be right." Instead, I am looking at their models, results, and the
  • by Catamaran ( 106796 ) on Tuesday August 30, 2005 @05:47PM (#13440195)
    I believe that the scientific Journal has outlived its usefulness, and will be replaced by ... Slashdot!

    But seriously, reviewers are biased and sloppy, as are the editors. The fact that reviews are blind means that they are also unaccountable, which fosters even more bias.

    Journals take months or years to respond to a submision, and often as not they respond with a rejection so the submitter has to give up or start the whole process over with another journal. There are so many scandals that one could quote. The whole process seems more designed to support the status quo than to promote knowledge.

    I have discussed this with many people in academia and they react not with logic, but with horror that I would dare to question a system that they view almost mystical reverence.

  • by davidwr ( 791652 ) on Tuesday August 30, 2005 @05:48PM (#13440197) Homepage Journal
    If a submitted paper is scientifically unsound, it should be rejected.

    If a scientific paper is useless to the readership, that publication should reject it and recommend a different journal.

    If a paper is wrong and the reviewers KNOW IT then they should send it back for corrections.

    If it's WRONG but the reviewers don't or more typically can't know it because it is novel, then publish it. The rightness or wrongness will be sorted out soon enough.

    Ever heard of Isaac Newton? Turns out his theories were incomplete in some very fundamental ways, but his theories regarding the motion of objects were the best approximations we had for hundreds of years and are still very useful for macroscopic objects traveling way below c.
  • So what? (Score:2, Insightful)

    by xiphoris ( 839465 )
    Newton's original papers on physics are all wrong. So what?

    They've been replaced by something else. Sure, they're generally true, enough to be taught in physics classes, but all the specifics on gravitation etc. are incorrect.

    They're being replaced with: (pick your theory) quantum gravity, string theory, quantum mechanics and more things I don't know.

    But so what? Science, by its nature, is always being improved upon. Any time you correct someone else's theory, you could say their theory is now wro
  • Even Funnier (Score:2, Interesting)

    by ReidMaynard ( 161608 )
    I know of a whole company based on a bad paper. Some type of "fast blood analyzer". After a number of bad pre-production starts, yelling matches between software and hardware people, firings, suings, quitings, it was finally determined that whole premmis (from a founder's scientific paper) was false.
  • Quote (Score:5, Insightful)

    by BenjyD ( 316700 ) on Tuesday August 30, 2005 @05:53PM (#13440250)
    "If we knew what we were doing, it wouldn't be research"

    That's what my supervisor used to say to me when I got depressed about lack of progress.
  • by ndansmith ( 582590 ) on Tuesday August 30, 2005 @05:56PM (#13440271)
    According to epidemiologist John Ioannidis, the majority of published articles on Slashdot are dupes. If Ioannidis's own paper is right, a randomly chosen story has less than a 50% chance of being original.
  • Science = Modeling (Score:3, Interesting)

    by sjbe ( 173966 ) on Tuesday August 30, 2005 @06:03PM (#13440341)
    "All models are wrong; some are useful" -George Box

    I'd say it's more like 100% of scientific papers are wrong, it's merely a question of the limitations of the model.
  • by DrCode ( 95839 ) on Tuesday August 30, 2005 @06:06PM (#13440362)
    If 50% are wrong, then 50% are right. So if I write a scientific paper, the chance of it being right is 1/2. And if I write the same paper, say, 8 times, the chance of it being right at least once is 255/256.

    I think I'll write that paper on statistics.

  • Indiana Jones:
    Archaeology is the search for fact, not truth. If it's truth you're looking for, Dr. Tyree's philosophy class is right down the hall.

    /Archaeology/Science/. Truth has no place here, it's fact we're after.
  • by Salis ( 52373 ) on Tuesday August 30, 2005 @06:16PM (#13440450) Journal
    The paper stating that ~50% of scientific papers are false is published in the Public Library of Science (PLOS) Medicine. The paper only examined medical studies and not scientific papers on physics, chemistry, engineering science, (and mathematics).

    While molecular biology papers can be prone to statistically insignicant, but factually stated conclusions, the biggest culprits are clinical studies and 'large-scale' analyses of data.

    Good experiments are constructed to give a 'yes' or 'no' answer based on the presence or absence of evidence. The zeal of high-throughput studies and analysis have put more pressure on good statistical analysis. Unfortunately, statistical analysis requires math...which sometimes eludes doctors and biologists. Hence, the problem of missuing statistics and stating inadequately supported conclusions.

    -Howard
  • Science and magic (Score:3, Interesting)

    by oGMo ( 379 ) on Tuesday August 30, 2005 @06:19PM (#13440475)

    Science is not about finding the truth. It has nothing to do with the truth; people who look to it for truth misunderstand it. Science, and the scientific method, are based on one thing: reproducible effect. I do X, Y, and Z, and T results. If this can be confirmed, reproduced independently, you might have something scientifically useful.

    Notice what this does not say: X, Y, and Z are "true"; Z is "true"; X, Y, and Z cause T. Nor does it state the meaning of X, Y, Z, or T. Nor does it say why, in the presence of X, Y, and Z, T occurs. These are irrelevant. The only thing science does, the only thing it is capable of, is one thing: testing if, in the presence of X, Y, and Z, we repeatedly get T. For most things, that's all that matters. This is the scientific method.

    Thus it is that science is, quite literally, magic. Look over most fictional magic systems. We have things like "if we say this spell, this thing happens." "If we write these symbols, this thing happens." "If I visualize this thing in my mind, this thing happens." "If a mix a pinch of this and a hair of that, this thing happens." Because it's reproducible, it's useful. The mechanic does not matter: only reproducible effect matters. If waving ones hands and saying a phrase were to be followed consistently by a minor explosion, it would be just as scientific as mixing two chemicals to produce the same effect.

    It doesn't matter why. Theories get revised consistently to fit the facts, to document reproducible effects. If phlostigen and ether were accurate and useful models, the fact they have been discarded for more useful models does not matter: science isn't about truth. It is about reproducible effects.

    This is why not clinging to pet theories (yes, this includes everyone's favorite: natural evolution) is important: the theories do not matter. One should never fit facts to a theory. One should create a theory to fit the facts.

    This is what makes science useful.

  • by syousef ( 465911 ) on Tuesday August 30, 2005 @06:48PM (#13440698) Journal
    Hate to get into metaphysics, but a scientific hypothesis or theory is only going to be able to predict a very restricted set of things.

    People often quote Newton's physics as being "proved wrong" by Einstein's relativity (and those same people often barely understand the limits of relativity with respect to the quantum mechanical world). However Newtonian physics is good enough for most (though not all) space mission planning since it's still quite accurate so long as you don't get near a large gravity well like the sun or travel too fast. So Newtonian physics isn't "wrong" it's just accurate to within a certain margin and useful under less general conditions than previously thought.

    That's what these non scientifically trained creationalist types miss. There is no right or wrong theory, even though that's how the popular scientific press reports it. There is only the ability of a theory to predict what can happen (or has happened) based on a set of conditions, and an accuracy under a given set of conditions. Newtonian physics is no more "wrong" than eating salad is. You just can't misuse it by applying it to the wrong set of conditions (don't eat that salad if you're allergic to the ingredients).
  • This is a model (Score:5, Insightful)

    by lelitsch ( 31136 ) on Tuesday August 30, 2005 @06:50PM (#13440718)
    Did anyone actually RTFP? It's one of the most spurious pieces of "research" I've ever read. And with a biophysics degree, I have read quite a few. The author actually didn't investigate any actual papers, but he builds a mathematical model out of his own biases, statistical projections, and some back of the envelope computation. Even then, his conclusions are much less stringent than the submitter makes them out to be. He "proves" that under all his assumptions, half the research papers *might* be wrong, but shows not even statistical evidence that they are.

    I think PLoS is peer reviewed, but that paper should never have survived peer review. Occasionally, bad papers slip through, even in the so called hard sciences. This one seems to be one of them. Since PLoS Medicine is pretty well respected for an open access publication, lets assume that this was a lark and more on.

    But it makes me curious what the fraction of bad papers looks like in an open access publication like PloS versus a traditional journal like, say, Nature, The Lancet, or New England Journal of Medicine. One reservation people have about open access (or author pays) models was that since PLoS gets paid about $1500 from they authors, they might be accepting vanity papers, or don't triage as well as traditional journals. I don't think they are, but if this paper is any indication, PLoS might take a second look at their peer review process.
    • Re:This is a model (Score:3, Informative)

      by Lars Arvestad ( 5049 )
      I have still to RTFP (put it on my list), but I did notice that this is an essay, and not a research article. As such, it probably did not go to peer review as it is more of a discussion piece.
  • by Ichoran ( 106539 ) on Tuesday August 30, 2005 @07:14PM (#13440921)
    When you think about it, that's positively astounding. There are vastly more ways to be wrong than to be right. We've managed to get 50% right answers out of the myriad wrong answers. Pretty impressive!

    It would be better still if it was more than 50%, but we can just apply the process repeatedly to push up our confidence (50%, 75%, 87.5%, etc.). A little more attention to statistics would help us raise the base rate above 50%.
  • by Jonathan ( 5011 ) on Tuesday August 30, 2005 @08:29PM (#13441622) Homepage
    There's a famous quote by Box: "All models are wrong; some models are useful". That's what science is all about -- making models, which are useful until a better model comes along. So by definition, 100% of *all* scientific papers are wrong. But some are wrong in useful ways that inspire new generations of scientists to improve upon them.
    • Papers, not theory (Score:3, Interesting)

      by mosb1000 ( 710161 )
      The problem is not that many scientific theories are wrong, we all knew that. The problem is that a majority of published scientific papers are provably wrong at the time of publication, and the author should've known that it was wrong, but is too stupid and/or busy to publish a correct one.

      Scientific papers are usually written by grad-students trying to earn a degree, and that is usually the only real purpose they will ever serve. The project I am working on now is a continuation of the work that was car
  • by skingers6894 ( 816110 ) on Tuesday August 30, 2005 @09:01PM (#13441889)
    ...there is a good chance he is wrong
  • by mcrbids ( 148650 ) on Wednesday August 31, 2005 @12:26AM (#13443207) Journal
    The death of Science, the growth of anti-intellectualism sweeping the United States, stems partly from the fact that most children never learn what Science is.

    Ask them. To most kids, science is a class they take, where they have to regurgitate "facts" like why the sky is blue, or how hydrogen and oxygen combine to create water. It's a boring class, unless you happen to sit next to an attractive member of the opposite sex, but then, it's still not the class that's interesting...

    Science is not 'fact' - Science is the best-known process by which truth can be reliably found.

    Science is somewhat like the mathematical function x=1/y. Forever approaching truth, never (exactly) reaching it, forever leaving curious minds with new things to explore. Science is the magical combination of "what if" combined with the "feet on the ground" of experimentation, independent scrutiny, and validation of theories.

    The "Scientific method" that is regurgitated by most Jr. High schoolers (in California, anyway) is never really *experienced* except in the case of the rare instructor who goes above and beyond the textbook curriculum. EG:
    1) Gather data.
     
    2) Form hypothesis.
     
    3) Test hypothesis.
     
    4) Determine conclusion
    What drudgery! If that really was science, I wouldn't be interested, either!

    It's sad. Entire generations of people who never get to experience the awe, wonder, and magic of science, who then seek out that awe and wonder by (best case scenario) watching magicians and listening to Art Bell, or (worst case scenario) performing criminal acts and doing drugs.

    How much of the interest in the pseudo-sciences (aliens, conspiracy theories, perpetual motion machines, telepathy, Scientology) comes from the fact that they have never really been exposed to the real thing?
  • "Not even wrong" (Score:3, Insightful)

    by alanw ( 1822 ) * <alan@wylie.me.uk> on Wednesday August 31, 2005 @01:32AM (#13443468) Homepage
    Wolfgang Pauli's comment on one scientific paper shows that there are worse things in science than just being incorrect. Science is always falsifiable.
  • by l3v1 ( 787564 ) on Wednesday August 31, 2005 @02:59AM (#13443785)
    Ok, as from someone who is in thie "business" of research, and papers "creation", you have to know, that there is no perfect idea, there is no perfect solution, there is no perfect paper. But this is not the goal, either. Conferences and conference papers are there to provide a ground for scientists to make their latest stuff public and let it be chewed and digested by others. It's after many iterations and discussions and quarrels sometimes, when one either gets to a point when the re- and re-corrected idea seems to work ok, or it turns out to be useless junk although it seemed like being good at first.

    I read many papers, I don't know numbers, but many dozens in a month. Usually I don't care if they seem good or bad, if they are correct or not. The ideas therein are what matter. Sometimes you get ideas on how to improve an old idea, sometimes you get new ideas from older papers. sometimes it's just nice to know what others are doing.

    The matter is very much different when you have to review papers, but the seriousness of that review also depends very much on how much time you have, possible IRL problems, etc., but that's why there are >=3 reviewers+associate editor assigned to the paper at most of the serious journals.

    Stating such things as a certain percent of all papers are crap is just crazy sh*t. It happens very seldom that I read a published (conference or journal) paper and I think it was useless. Anyway, if it would be true that would mean that this guy's paper is also half useless. You are free to choose which half :P
     

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