

Eye Transplant Enables Blind Boy to See 309
Chris Gondek points to this story carried by the Sydney Morning Herald, excerpting: "A one-year-old Pakistani boy saw the world for the first time yesterday through an eye donated by an Indian. Mohammed Ahmed gained partial vision after a difficult operation at the Agarwal Eye Institute in the southern city of Madras. Doctors said Ahmed, who was born blind, would get near-normal sight by the time he heads back to Karachi next week."
Careful... (Score:5, Informative)
The title suggests that the whole eye was transplanted which would indeed be very exciting as I myself work in vision rescue focusing on diseases that cause blindness through degeneration of the retina. However, the concept of rescuing vision once we have lost it due to trauma to the retina or degenerative diseases is much more difficult than simply replacing the tissue with a healthy donor tissue. We are working with a number of folks on bionic and biological therapies and replacements for retinal vision loss, but it is a challenging prospect despite what some commercial organizations would have the media believe.
In addition to the above mentioned corrections, there are other problems with this story. In particular, apparently the child was born blind from birth which would suggest that depending upon how old the child is, there will be problems due to vision being occluded during certain critical periods of vision pathway development. This means that there may be no vision in the eye that was clouded anyway, or that vision may not be fully "normal" and likely will never be.
(yes, I am a vision scientist)
Re:Careful... (Score:2, Interesting)
Re:Careful... (Score:2)
Gee, I bet neighborhood bullies and `disturbed kids' everywhere would give an arm and a leg to get to the university offering that course.
Re:Careful... (Score:5, Interesting)
What do you think are the chances of ever seeing a complete eye transplant ? In 10 years ? 50 ? 100 ? Or maybe never at all ?
Re:Careful... (Score:5, Interesting)
I've thought about this a lot. There is some very promising research in the neuromuscular community that suggests that spinal motor neurons can rewire rather successfully. The problem is that the retina (and the "wires" (axons) that come off of it is a very complicated tissue and rewiring them might be too much to attempt even if you could 1) get the retinal neurons to survive and 2) get them to rewire properly and perform the precise pathfinding necessary. Immunological considerations are another issue, so the approaches I am interested in a other biological and possibly bionic approaches.
Re:Careful... (Score:5, Informative)
True...Need more Funding. (Score:5, Insightful)
I think much more money should be spent in this kind of research. Immortality is just around the corner if successful brain transplants can take place. As well people inprisoned in quadriplegic bodies can be helped by this research along with many others with similiar neuron/motor neuron problems.
Re:True...Need more Funding. (Score:5, Informative)
Making stem cells to specialize into kidney cells is not quite as hard as producing functional neurons and making their growth cones migrate exactly where wanted -- The "wires" aren't the biggest problem, it's the signaling that takes place to connect the wires into something that has a wanted physiological meaning.
And there's very active research going into understanding nerve cell targeting. The problem is just that the successful process of nerve cell growth is a result of a fine balance of a huge number of extracellular signals -- different guidance cues, repelling signals, survival factors, cell-to-cell adherence molecules, etc, etc. The basis is known, but it also appears to be one huge area of intracellular signaling research to cover.
Re:True...Need more Funding. (Score:5, Interesting)
I'm just wondering how much precision is really required, and how much the brain can compensate for after the fact.
Does it even make sense to think of the optic nerve as a bundle of parallel wires?
Re:True...Need more Funding. (Score:2)
I think it may depend on how "young" you get the transplant done and if the person has had sight in the past. My understanding is that the brain essentially figures out the connections initially anyway, so there is a large margin for error in the wiring as long as the brain hasn't already wired it one way.
There are some decent medical eye books [health-issue-books.com] available if you're really interested in the details.
Re:True...Need more Funding. (Score:3, Interesting)
This is from experiments on cats who were forced to wear some kind of optical contraption in front of their eyes from birth that reversed the field of their vision (i.e: everything was upside down). The cats learned to use this type of input and developed normal vision. When the contraption was removed, all cats are very confused for a while, but if cats are young enough at the time of the removal their brain
Re:True...Need more Funding. (Score:2, Interesting)
In a way its healthy for our population when individuals don't live too long.
Re:True...Need more Funding. (Score:2)
So, just out of curiosity... if not the brain, what is?
Re:True...Need more Funding. (Score:2)
So - the rest of the body is necessary, then? IANANeuroscientist, but it seems to me that I'm still the same person even if I have prosthetic arms, or a transplanted heart or liver - the brain is the only organ I can think of for which I cannot say that.
Are you referring to the effects of hormones and so on? If so, you probably have a case there: I wonder what the effect would be if my brain were transplanted into a
Re:True...Need more Funding. (Score:3, Interesting)
Is the car the same car after fueling? After an oil change? After a new engine has been put in? After a paint job?
See, the same kinds of questions can be asked about something totally unrelated to neuroscience, and this is a huge clue.
And, don't make the mistake to presume these questions about cars can be answered by car mechanics. Where would they start? How would they determine what constitutes a car without engaging in reflection on concepts, viz. philo
Re:True...Need more Funding. (Score:3, Interesting)
So, going by my meaning of 'person', I would say: 'I am a person, implemented
Re:True...Need more Funding. (Score:5, Insightful)
Re:True...Need more Funding. (Score:2, Interesting)
Re:True...Need more Funding. (Score:2)
You could argue that 'how we see ourselves, the body, bla bla bla" affects who we are too, but that wouldn't be a problem. You could just clone yourself from cells
taken and frozen when you were born (I read somewhere that cells remember their age, or rather, that the levels of some chemical inrease as we age), and start
growing a new you 20 yea
The brain is not the person? (Score:2)
Re:True...Need more Funding. (Score:2, Informative)
You can grow a headless (or brainless) body in a vat. They've already grown headless mice:
Time Magazine Summary on Headless Mice. [time.com]
As well, I suppose, it might be easier just to transplant out all your organs. Do arm transplants, skin transplants, organ transplants, and build a new body around the old brain.
Key areas of research I'd want is:
Re:True...Need more Funding. (Score:2)
(-: Well, I've heard (from her relatives) that a nurse in a transplantation ward called a speeding, bad motorcycle driver "donation material". Just vote against laws demanding helmets for motorcyclists... :-)
Seriously, the first step is to keep the brain and body reasonably healthy a few decades more. Solutions after that (remakin
Re:True...Need more Funding. (Score:2)
It's probability -- not certain. I'd give good odds all life (biological and silicon) is extinct in a century, anyway. We just don't know.
But I am quite certain that you guys'll have a good time without me, even if I like to think it could have been a little more interesting/strange with me.
If you're lucky, drink a beer for me in a century. If you still have a throat then. :-)
Re:True...Need more Funding. (Score:3, Informative)
As a neuroscientist, I can tell you that you are wrong. The brain does age along with the body, old brains do not look like young brains. Some do age much better than others, but the same is true of the rest of the body as well. Damage from oxygen radicals happens in neurons and glia, just as it does in every other type of cell in the body.
Re:True...Need more Funding. (Score:2)
In a situation where 'it's him or me', surely one cannot be blamed for choosing 'me'? Now, if I'm faced with the choice of either dying myself, or letting someone else die, I'll surely let them die. So why shouldn't I take the body of a child to house my brain, rather than permit my own death?
It's him or me. I choose me.
However, there is still this difficulty that it
Re:Careful... (Score:3, Insightful)
I doubt we'll see perfect transplants for a LONG time, but something that would "work" is not that far off.
Re:Careful... (Score:5, Interesting)
Would re-wiring the nerves properly be THAT important in allowing the eye to send information to the Brain?
The brain has astounded scientists in it's ability to reconfigure itself so as to perform the same tasks, but using a different region
For example, I remember a story about a boy who had a hemisperectomy. Doctors expected him to wake up paralysed down one side of his body, but, when he did wake up, he could do everything he could before. Which, IMO, amazing.
Re:Careful... (Score:2)
I don't know much about optic nerves, but based on those brain experiments, the procedure even if "succesful" may not lead to anything remotely like normal vision. In fact those wayward
Re:Careful... (Score:2, Interesting)
There's a famous experiment where a frog eye was removed and reattached inverted 180 degrees, and the frog never compensated (it would shoot it's tongue out the wrong direction when trying to eat flies, and had to be fed by hand for the rest of it's life) (vision scientist types - do you know the name of the guy who did the experiment?)
Another piece of evidence is the development of ocular dominance columns, which were hinted at in an earlier post - essentially, if you occlude one eye of a
Re:Careful... (Score:3, Interesting)
I'll be damned if I remember anything more than these few details about it, but I recall reading about an experiment where a college kid was given glasses that reversed his
Re:Careful... (Score:3, Informative)
We also know (or think we know) that much of the functionality within visual cortex is built through some self-organizational algorithm during early development. (Witness horrible exp
Re:Careful... (Score:2, Funny)
Re:Careful... (Score:5, Informative)
(another vision scientist)
Re:Careful... (Score:2)
In his 1998 experiment, a 100-element probe was attached to the medial nerve (??) of his left hand (sorry, biologist/ MDs, I don't know the correct terms. I am an engineer who research on the mechantronic side of robot...), which has about ten thousand cell axons. The connection is kind of random. A learning process was involved so that Kevin can sensor and control using the new connections...
You're right (Score:2)
An "Ask Slashdot" for the vision scientist(s) (Score:5, Interesting)
Re:An "Ask Slashdot" for the vision scientist(s) (Score:2)
If eyetracking were practical, encoders would even only transmit what you are looking at, but do you want to wear a few pounds of gear on your head to watch television? Once eye trackers get cheap and small enough, however, even that
Vision decoding mechanism (Score:5, Informative)
The information is never used as-is by the brain, but at each stage it processed, and information is extracted and spareted.
The vision, for exemple, doesn't work at all like in a computer with a pixel grid.
The input from the cones and the rods (the "pixels") is not sended as-is to the brain. Instead, in other layers of the retina, value from rods close to each other is compared (for : exemple you have "off-/ and on-centers", a signal is genrated only if surrounding cones are off and central cone are on, meaning there's something in the middle of that region).
The information transmited in the optical nerve isn't "pixel at coordinate (150,175) is color rgb(126,129,32)" but "there a change between these points and their neighbours, so there must be something there".
Further stages in the brain works the same way
point are compared together to extract edges (comparing point close together), or motion directions (comparing the timing between two near region).
Then motion, shape, colour, etc... is processed independently in deffirent arrea of the brain.
This analysis is also done at different frequencices : some region compare difference between point very close to eachother, where other regions compare global differences between the two half of your field-of-view.
So : when you see a red pen falling, you're brain isn't processing the images at a whole (not like a sequences of pictures of the pen falling).
But one region of your brain say it found a red object, another region of your brain tells there's an object that is long and thin, a third region see ther's motion going downward, etc...
Also, it isn't possible to have a single nerve fiber for each "pixel" while keeping a high resolution. So there's some kind of information drop : only the center of the view has a high density of receptors (cones & rods), the rest of the field of view has much less receptors.
Only the center of the view can see fine details.
The rest cannot give details, but can still give an alrt if there's something, and you'll automatically point your eyes int that directions to bring the interesting objet in you "high resolution" zone.
The whole scene is the kept reconstucted in some kinf of mental visual scratch pad.
So when you look at a plant you can see it well with all details, leaves, etc...
Then when you look at your computer screen, you can't see that plant that well, but even in your peripheral vision you can still a bullry green spot, and you remembre that you saw a plant there. Even if you can't see details anymore, your brain can still notice that the green spot has suddenly turned brown-orange. You turn your eyes and see that you can is trying to eat your plants....
This also explains why we don't "see" our blind spot. (Due to some poor cabling, the optical nerve is running thru the retina, and there's no receptor in that place, to leave room for the nerve).
It's like a grid with some pixels missing.
The vision works by comparing points. It's just that in the blind spot, the brain is comparing receptors that are VERY far appart. So if something small is located just in the blind spot, we won't see it, but we won't even realise that we are missing it, because when the brain compare the points above, below and on the sides of this spot, it doesn't notice any change, so the brain thinks the background is continuous. (That's what some call 'filling the gaps').
Re:An "Ask Slashdot" for the vision scientist(s) (Score:2)
Re:Careful... (Score:2)
where's the little combobox to mod down the insensitive clod that submitted the article....
Re: (Score:2)
Re:Careful... (Score:2)
Re:Careful... (Score:2)
Re:Careful... (Score:5, Interesting)
Thus my interest.
a "BladeRunner" level of futuristic technology. "I made your eyes", etc
I am working on it.... Seriously.....
It would presumably also be relatively easy to graft an artificial electronic "eye", to create vision enhanced cyborgs - or to plug a video feed straight into the optic nerve for the ultimate in immersive graphics.
There are folks that are working on these solutions as well. One guy has a good approach while the others are basing their solutions on flawed assumptions of the basic biology. We are working on correcting these flawed assumptions.
Re:Careful... (Score:3, Interesting)
My limited understanding as a lay person is that vision is dependent upon unimpeded development during a critical period at a very young age.
Re:Careful... (Score:2, Interesting)
You are hinting that it looks feasable to you for constructing interfaces to take a high-speed binary serial stream, using some sort of implantable serial to parallel converter, to generate a video signal which would be like that on the optic nerve and recognizible by the brain as video?
Bridging the gap between binary electronics and and the neurological networks of life has got to be the biggest "hack" of all time.
Although I feel I understand the former extremely intimately, I am absolutely in the c
there goes biometric identification (Score:4, Funny)
Re: (Score:3, Interesting)
It depends also on the brain itself. (Score:2, Interesting)
It is because the center of vision finish developping at a certain age.
In your exemple, if the person is a ful grown adult when he looses his eyes, he has an already functionnating center of vision. And when he has a new eye, he'll be able to use it again.
If he lost his eye when he was a baby, and he waits until he's 20 before gettint a new eye, the new eye won't work, because during the childhood, t
One year old? (Score:4, Interesting)
-FP??
Re:One year old? (Score:4, Funny)
Re:One year old? (Score:5, Funny)
Afterwards, the doctors gave him two punches to the arm for "flinching like a wussy". Doctors can be so childish sometimes.
Re:One year old? (Score:2, Informative)
Well duh (Score:5, Informative)
There are also simpler tests. wave a hand a quickly in front and note reaction, move a light and watch if the eye follows it.
How much he sees and how well is of course another question. But if you had the choice between being completly blind and being able to see a ball on a table what would you choose?
Re:One year old? (Score:5, Informative)
Re:One year old? (Score:2)
Re: (Score:2, Informative)
http://www.quotedb.com/quotes/1908 (Score:5, Funny)
"An eye for an eye, and soon the whole world is blind." -- Gandhi
Oh, wait.
Anyone spare an eye for a computer nerd? (Score:3, Funny)
Though from the first few comments here looks like I shouldnt hold my breath. Better keep waiting for the video camera borg-eyes.
Re:Anyone spare an eye for a computer nerd? (Score:3, Funny)
I dont believe that medical mumbo-jumbo.
Re:Anyone spare an eye for a computer nerd? (Score:5, Interesting)
Staring at a screen all day every day will cause your eyesight to get worse.
Put an eye chart on a wall 15 feet away, and look at it every 15 minutes. Your eyesight WILL improve.
Re:Anyone spare an eye for a computer nerd? (Score:3, Informative)
Re:Anyone spare an eye for a computer nerd? (Score:2)
Part of the training regime involved sitting in front of what looked like PC screens and focusing on the various images that were displayed (at least that's what it looked like from the TV report!).
Brings new meaning... (Score:4, Funny)
OMFG it's like "body parts" meets "the eye" (Score:3, Funny)
THIS FILM APPROVED BY THE PAKISTANI FILM COMMISSION
After the eye works, then what? (Score:5, Interesting)
I feel feel squicked just thinking about this, but I wonder if that kid will ever have really useable vision.
Re:After the eye works, then what? (Score:3, Informative)
Humans develop more slo
Good news links (Score:5, Informative)
Star Trek: TNG (Score:5, Funny)
Dear Geordi,
Congratulations on your eyesight.
More power to the engines,
Captain Your Name Here
Man wtf Slashdot (Score:2, Insightful)
Re:Man wtf Slashdot (Score:3, Interesting)
Specifics shmecifics (Score:4, Insightful)
State of Affairs ! (Score:4, Interesting)
What about the psychological aspect? (Score:5, Interesting)
Will this boy have the same problems?
Re:What about the psychological aspect? (Score:2)
A newborn can cope with it very quickly, as they don't even have a sense of dimensions. However, it is more difficult for an adult to cope with it.
I've heard of a similar story, about a man who couldn't live in the world he could see. I think Hollywood made this film [imdb.com] inspi
Re:What about the psychological aspect? (Score:3, Informative)
Not pop psychology (Score:2)
Not that special ... (Score:2)
I suppose the politcal statement is fairly important in terms of pakistan / india relations.
nick
Pakistani with Indian Eyes (Score:2)
Next they'll work on teeth.
what a Hard Surgery... (Score:2, Insightful)
Somewhat of a personal experience (Score:5, Interesting)
They first had to do a plaster mold of his eye (the first one broke). And then he had to sit and wait for an acceptable donor.
When the cornea came in, they numbed his eye completely (locally) and all the surrounding area (he was fully awake when the procedure was done). And stitched in the new cornea.
Late one night, I was sitting in the hospital room with my dad -- this is late the very same day (mind you, I was only 14 when this was done) -- the nurse came in to change dad's eyepatch, reapply some goo, and just do a general check. Soon as the nurse walked out of the room, my dad grabbed me and said, "Holy shit, son. I JUST saw DEPTH! I can't f*ckin' believe it. I saw in three dimensions!!!!" -- I've never saw my dad so excited over something. I told him something to the affect of "welcome to the world of depth" or something stupid like that. He told me to wear one of his eyepatches for a day, then take it off and look at how different the world was.
Later on some months, I couldn't handle driving with him. "The TREES are coming AT ME!!!"
I guess we stereoptic folks take this stuff for granted sometimes.
--Xan
Re:Somewhat of a personal experience (Score:3, Funny)
I trust you did the right thing... and took him to a strip club immediately thereafter? :)
You're So Lost In Technical Details.... (Score:4, Informative)
If you had RTFA you would know that it wasn't about the technical details of some new surgery. Far from it.
For those who wont RTFA, it was mostly about doctors in India helping children from Pakistan. And for thost who won't read anything but
Re:You're So Lost In Technical Details.... (Score:4, Insightful)
Actually there's never been a people-to-people problem between India and Pakistan: visitors from one country generally feel overwhelmed by the hospitality shown in the other. Indian films are hugely popular in Pakistan, Pakistani singers are hugely popular in India.
Last year, having spent a year (my first) in the US, I visited India for a few weeks. I had just left a country where the press was heaping the vilest and most unspeakably vulgar abuse on a historical ally, France, for daring to suggest that the Iraq war may not be necessary. The NYT had just run a story on how French high-school students, visiting the US on long-established exchange programmes, were not able to find American families willing to accommodate them (the same story also remarked, by the way, how Americans continued to be welcome in France -- something I can believe, I had lived two years in France before that.)
And I was now in my home country, India, where the papers were full of goodwill stories on the heart operation on a girl from the "enemy country", Pakistan, and the Pakistani parents were feeling overwhelmed by the good wishes they had received. (A few months ago, when the Indian cricket team toured Pakistan for the first time since the 1980s, Indian fans visiting Pakistan experienced similar hospitality.) This wasn't a surprise but it was hugely pleasant to see after a year watching Americans puke all over their oldest ally.
I had already decided that the US was not the country for me, but last year was when it crystallised: the US may be the most developed nation in the world but it's also the most immature in many ways: no other country uses the words "enemy" and "evil" so routinely and unthinkingly. I'm leaving for home in a few weeks.
I want better eyes than human eyes (Score:2, Interesting)
Rather young for a Wolfram & Hart employee (Score:2)
Re:Errr... (Score:5, Funny)
A slow learner then, maybe?
Just kidding...
What's important in the story: (Score:2)
2.) The Pakistani couple had the work done in an Indian hospital by Indian doctors using Indian donors. Ok, it happens all the time; but, given the political climate in that part of the world, this is worth mentioning too.
Re:A very promising technique (Score:5, Informative)
The issue is much more complicated than these individuals would have you believe. There are a couple of corporations that have been started that are very good with media hype. They have good engineers, but the engineers are looking for a solution without understanding what the biology is.
Re:A very promising technique (Score:2, Interesting)
To be honest, yes. To me being blind sounds like hell and I couldn't imagine a worse disability. Obviously that's because I've been able to see for the past 20 years, so it might be different for someone who was born blind, but if someone said "vision and kidney/joint problems or blindness" it wouldn't be a particularly hard decision for me to make.
bad, but not terrible (Score:3, Interesting)
It's not that bad. I'm not blind, but I do know and work with quite a lot of people who are, and you would be amazed at their independence and their quality of life. Like you suggested, many people who have never been able to see are perfectly content with their 'disability', and indeed can't imagine anything else. One of my friends says that if sight-restoring operations were possible in an everyday sense (which they certainly aren't), he would probably not take it. I'm not sure how typical of the blind co
Re:A very promising technique (Score:2)
Re:A very promising technique (Score:2)
Re:A very promising technique (Score:5, Interesting)
I suppose that it would be possible to make electronic connections deep into the brain (past the optic nerve) to get around this. But I would still be skeptical that the brain would ever be able to adjust to processing the new information.
Re:Reasons why? (Score:5, Insightful)
"Last year, a life-saving heart surgery was performed on two-year-old Pakistani girl Noor Fathima at a hospital in Bangalore, also in southern India. Since then a steady stream of Pakistani children has flocked to India seeking treatment for variety of ailments."
It may be that the Pakistanis will become increasingly dependant on India for medical care along with other social support services. This is increasingly likely as Pakistan remains fairly backwards and impoverished while India continues to modernize and grow in wealth.
If this trend does develop, and persist, Pakistan may be forced to improve its relationship with India for the express purpose of maintaining the availability of these services for its people.
Re:Reasons why? (Score:2)
Re:Reasons why? (Score:2, Insightful)
I'm not completely ignorant, and I realise that there us such a thing as a Cashmere Conflict. That's what I find so disappointing about this world. People still hold archaic views about nationality and territory. People can hav
Re:Yeah worked really well in the rest of the worl (Score:2)
Second, the US-backed forces in Afghanistan in the '80s largely preceeded the Taliban, which is mostly a Pakistani export.
Re:Yeah worked really well in the rest of the worl (Score:2)
Second, the US-backed forces in Afghanistan in the '80s largely preceeded the Taliban, which is mostly a Pakistani export.
You are partially right here. The Taliban came into being in the mid 1990s.
However, they are not mostly Pakistani export. They are a reaction to what happened over the decades of foreign invasion, international neglect, civil war, insecurity, ...etc.
After the USSR pulled out of Afghanistan, the US (and the rest of the world) lost interest. The Mujaheddin who fought the Soviets and
Re:Reasons why? (Score:2)
FYI, India's medical support (especially in the private sector) is among the best in the world, for those who can afford it; and it is much cheaper than equivalent medical care in the west. "Medical tourism" is a significant and growing [www.cbc.ca] industry. (That was a lazy google-generated link, you can find more the same way.) Moreover, even the private sector routinely waives fees for patients who can't afford them, and private doc