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Science

First Human Clone Eight Weeks Along 551

Vegeta99 writes "An Italian researcher is claiming ground-breaking progress, and has successfully cloned a human, and the mother is now 8 weeks pregnant, according to this article. Now how long until I can buy my own clone?" It's worth noting that the Roman medical associations bioethicists denied Dr. Antinori permission to proceed with these experiments last month. So doing the math, Rome was a little late... If the pregnancy continues without miscarriage, the tyke may share a birthday with Marie Curie
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First Human Clone Eight Weeks Along

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  • This is not going to end well...

  • by flipflapflopflup ( 311459 ) on Friday April 05, 2002 @06:36AM (#3289566) Homepage
    Worse than growing up and finding out you were an accident, this kid grows up, and finds out he is illegal!

    Nice.

    • Isn't having a bastard child still illegal in some places? It's only a matter of time before people relax/let slip their moral views on the whole thing like they did with kids bon out of wedlock. Lucky for me I was born in such a lax time.
      • by bartyboy ( 99076 )
        Is the relaxing of moral views really such a good thing? Today we accept cloning. Tomorrow we accept euthanasia of clones who are not healthy. The day after, we accept killing old people who are not healthy. Then we accept killing all people with uncurable diseases. Sure, we have strenuous procedures and laws for all of these, but we're still guilty of clensing the human race. (Rememeber Hitler?)

        These are all logical steps. Maybe not within 4 days, 4 years or 4 generations, but they are certainly possible.

        The loss of high moral standards is not always a good thing.
        • by gowen ( 141411 ) <gwowen@gmail.com> on Friday April 05, 2002 @09:14AM (#3289921) Homepage Journal
          Lets see:

          Reference to Hitler? Check
          Slippery slope fallacy? [nizkor.org] Check
          Utterly unsupported reference to "logic"? Check

          You sir, are a troll.
          • by uigrad_2000 ( 398500 ) on Friday April 05, 2002 @12:36PM (#3291063) Homepage Journal
            It's hardly comparable.

            He suggests that euthanasia will soon be allowed for clones. You think it's improbable.

            The article mentions that there's about a 4% chance of deformation. I'm guessing that's a low estimate. The scientist is trying to sell people on the idea, so he's going to say something that sounds good. What if 5 of the next 20 cloned humans are badly deformed?

            If we don't "slide down the slippery slope", then those deformed children will be kept alive. Cloning of humans will be discouraged, because of the poor success rate (4% is a poor success rate too, IMNSHO), but it will still happen. Fertility drugs are discouraged for women who are fertile, yet they're abused from time to time too.

            In any case, neither option (euthanasia or deformed children) is good. You live in a dream world if you think that guy's worry is implausible. It certainly is worth discussing. I think you, sir, are the troll.

        • Just because we accept one does not mean we HAVE to accept the others. Man is a thinking creature and has choices about what he or she allows to happen. Just because something is logical does not mean it is mandatory (selling Crack for money is logical and we still do not let GM do it legally) no matter what people who believe that logic is a sine qua non happen to believe.

          Furthermore, I challenge the assumption that euthanesia would not be controlled by the patient (I'm from Oregon, we're funny that way) and that killing unhealthy old people or people with incurable diseases is "logical". In the end, whether people live or die has nothing to do with logic and everything to do with value. The fact that you see all of these items as logical steps says more about your value structure than about reality.

          And whoever modded this tripe up as "Insightful" must truly be illogical.

        • Nature used to do a pretty good job of 'cleansing the human race' with diseases, aging, etc. In recent times, people are living longer because our society has changed so much. Science and medicine is inadvertantly creating longer lives for most and helping those who wouldn't have made it past age 6 a hundred years ago to live until they're much, much older.

          Personally I don't have a problem with any of this, so don't take offense, just look at this from a purely logical standpoint.

          Who will feed this giant new geriatric population? How will they be supported? Is the quality of life overall better for everyone or for the geriatrics now?

          The main question you have to ask yourself is this: is living longer better? I don't know if it's a good idea to have everyone living well into their 90's. I don't know if it's good to help chronically ill people survive. Given the tendency of nature to kill the weak and support the strong, some science and medicine is circumventing the bonuses to genetic propagation. If the weak and strong both survive, if the terminally ill pass their genes on to their children, what's the outcome in a hundred years? I'm all for gene therapy but extending lifespan of an entire continent is not really a good idea.

          This is a fascinating topic and I'd love to go into more detail but I already feel a flame, a troll and whatever other bad mods coming down on me.

  • by Johnso ( 520335 ) on Friday April 05, 2002 @06:36AM (#3289567)
    Most couples they had interviewed, he said, wanted to have a biological child of their own. In fact, cloning creates ordinary children who grow up to be unique individuals, he claimed.
    Unique individuals, like my brother Johnso1, Johnso2, Johnso3...
  • Birthday (Score:2, Funny)

    by DataSquid ( 33187 )
    If the pregnancy continues without miscarriage, the tyke may share a birthday with Marie Curie
    Yeah, but it'd be a little late for the new Star Wars movie ;)
  • by ferrocene ( 203243 ) on Friday April 05, 2002 @06:38AM (#3289572) Journal
    They're simply time-shifted identical twins!

    -e
    • yup. Nothing a little voyage at near-lightspeed can't fix.

      Offcourse if, one day, the kid finds out he's got exactly the same little wiener as his dad, lorena bobbit might actually start a proffitable bussines
    • The problem is that most of the cloned animals already died or suffer from genetical diseases..

      Until the chance of creating a kid who will die in (say) 5 years has not been minimised, i think this is very unethical..

      How will they explain him, that he was born to die in 5 years? That they knew hi will die, and still made him?
    • by HiQ ( 159108 ) on Friday April 05, 2002 @07:15AM (#3289665)
      I think that there is a little more to it than that. As an other poster already pointed out, the close receives the same DNA as the parent. But DNA changes during the course of your life, due to copying errors (amongst others). One of the current theories is that ageing has got something to do with the 'wear and tear' of certain parts within the DNA (repeating 'nonsense' groups). So your clone will have all this at the moment of birth, and AFAIK that's not a good start.
      • by emil ( 695 ) on Friday April 05, 2002 @09:17AM (#3289932)

        I read an article some time ago that Dolly the sheep had developed arthritis and was suffering from obesity, both of these conditions being extremely rare for her age.

        This person that has been created may suffer from intense health problems. I consider this action to be extremely unwise, as it will play into the hands of extremists seeking a ban.

        I personally would like to see cloning technology developed, but used on humans only when it is both safe and effective.

        • I personally would like to see cloning technology developed, but used on humans only when it is both safe and effective.

          Even if the cloning industry perfects the cloning of certain animals to the point where it's "both safe and effective", it doesn't follow that human cloning will automatically reach that state. Every animal is different, so to reach a state where human cloning is "both safe and effective", actual human cloning experiments are required to allow it to reach that state. I'm not saying that I condone the experiments; I'm just pointing out that your logic is flawed. If you want human cloning to someday be "both safe and effective", you must concede to allowing human cloning experiments that involve a certain amount of risk.

          • It depends on what you want. There is no point or need in cloning an entire person. Once they can actually have a chance at performing brain transplants, successfully, there might be a need, but I do not see that coming for quite some time.

            What would be useful now is a way to clone a specific part of the human anotomy. Hearts, livers and kidneys should be where the experimentation is done. It also has the benefit of not treading against any morals.

            I have problems with cloning a human being but not the body parts.
    • by popeyethesailor ( 325796 ) on Friday April 05, 2002 @07:27AM (#3289694)
      It's a lil more involved than that.. This Old BBC interview [bbc.co.uk] gives a layman's explanation of what's involved.
    • by javilon ( 99157 ) on Friday April 05, 2002 @07:28AM (#3289696) Homepage
      " They're simply time-shifted identical twins!"

      Well, then maybe the RIAA has something to say about it!
    • They're simply time-shifted identical twins!

      Whould you want to be one?

      But apart from that, this 'researcher' is playing with the live of this kid. As said by previous posters, the risks are very big. Would you like to test a 'bullet proof vest' that had bad results when tested on animals? That like the thing that is happening to this child, he might be born, will be subject to all kinds of research for the rest of his life and risks all kind of very serious health problems. I woudn't want to explain that to my child!

      Besides, what's the use of it? We'll might some day have 'time-shifted identical twins', so what? The only use there I see are things like a spare president, are a new Bin Laden every year, just in case somebody catches him. And ofcourse it's good for the huge ego of Dr. Antinori.
      It's not worth it...
  • Clone: Hello! I'm #15
    Cute Chick: Well hello hansome! What star sign are you?
    Clone: Pyrex
    Cute Chick: Ohhh baby!

    And things go downhill from there.

  • by nyjx ( 523123 ) on Friday April 05, 2002 @06:41AM (#3289590) Homepage
    Strange that this news has been "let slip" rather than have a prior press announcement. The article says: Dr Antinori revealed: "Our project is at a very advanced stage. One woman among the thousands of infertile couples in the programme is eight weeks pregnant.". Is there proof this is the result of the implanted cloned cells? None of the main news sites have picked this up yet & Antinori is know to be quite a "publicist".

    Maybe there was no announcement due to potential illegality but then surely you wouldn't leak the news in any way!

    • Bah... the good Doctor probably just knocked up his lab assistant and he's claiming she's got a clone in the oven instead of trying to explain his infidelity to his wife.
  • I just might get a first post:) Probably not, since I'm going to put some content here, but it's a nice thought.

    I must say I'm a little torn on the issue. It's great if the technology can grow livers and hearts and kidneys and bone marrow and what have you, but I'm not sure there's any good reason to clone entire people. It'll be interesting to see how this all plays out, in any event.
  • What is this? Apocalypse hour on Slashdot? First the story on the implantable microchips, now clones...

    BRx.
  • by Anonymous Coward on Friday April 05, 2002 @06:52AM (#3289610)
    All Mammal clones possible so far are FEMALE!

    You will never see this fact cited ever in a non-journal article.

    I have looked carefully in every news release since the original Dolly wave of press hysteria.

    Cloning will never be popular or interesting until telomere ends can be repaired in the zygote to prevent bio-clock failures (aging too fast).

    Cloning will also never be popular unless the person paying for the service (a rich white or asian male) can replicate himself, or his son.

    You read it here first... In 2002 only female mammals are capable of being cloned.

    (maybe they try to reduce rna conflicts from differring mitochondrial dna)

    These clones only clone the genes in the chromosomes alone and not the mitochondrial entities (entombed bacteria from billions of years ago in evolution).
    • All Mammal clones possible so far are FEMALE!

      Well if these scientists have the same problems with women that computer geeks have, then it's no wonder...
    • by damiangerous ( 218679 ) <1ndt7174ekq80001@sneakemail.com> on Friday April 05, 2002 @10:11AM (#3290109)
      All Mammal clones possible so far are FEMALE!
      You will never see this fact cited ever in a non-journal article.

      You will never see this "fact" because it really isn't a fact.
      See this article [wired.com] from way back in 1999 about the first male mouse clone.
    • There is a kind of cloning, parthenogenesis, which only clones females. Dandelions and some amphibians do this as a matter of course, and it has been observed to naturally occur in mammals (rarely).

      Somatic cell nuclear transfer is what most people are talking about when they talk about "cloning", and it can produce a clone of either males or females. However, with the current technology these clones have health problems throughout their (short) life. It is downright evil to use the technology to produce humans right now, since you're condemning the progeny to a short and unpleasant life. I have no ethical problems with cloning per se, just with any technology that makes people who will have a crappy quality of life.
  • I think that some people, when they hear the word "clone" used, they immediately think that it is literally a clone -- the same appearance, the same likes, dislikes, etc. However, that isn't the case -- it is just a clone on the genetic level. The child will grow up and have different experiences, will probably look different, like different things, etc.

    Think twins. Sorta.
  • Disturbing (Score:5, Insightful)

    by Captain Large Face ( 559804 ) on Friday April 05, 2002 @06:59AM (#3289624) Homepage

    It is ever-so-slightly worrying that the doctor in question, Severino Antinori, admitted in a press conference that Dolly, the cloned sheep, was suffering from premature aging. His defence, that the experiments were not conducted well, and that sheep cloning is vastly different to human cloning, does not inspire confidence.

    This child (presuming it survives) is nothing more than a guinea pig for Dr. Antinori's ego. Will this child be able to live a normal life? No. Look at Dolly -- how many tests do you think she goes through on a daily basis?

    Whilst I am reluctant to encourage animal testing, would it not be better for those in the same field as Dr. Antinori to perfect cloning of non-humans before moving onto humans? It seems the doctor is in a hurry to stake his name in history. If he is not careful, he'll get his wish, but it will appear closer to Josef Mengele than Marie Curie.

  • I suppose wanting to drive thing to the edge of what's possible is something that is built into human beings, but, in the case of cloning I think this just is irresponsible. Aside from all the ethical stuff (Like in The Boys from Brazil by Ira Levin) chances are that the child won't live long because on DNA level the child is as old as the mother, but there are no definitive conclusions on that. All in all I think it unacceptable to perform such extreme experiments un children (or animals) who don't have a say in their treatment.
    If only human beings knew their limits when messing around with technology some of the worst atrocities wouldn't have happened, but some revolutionary things that have enabled to prolong life and welfare on higher age wouldn't be discovered either. Fortunately I am no philosopher, or I would be driven mad when trying to decide whether technology is a blessing or a curse.

    Quote from Blade Runner:
    Replicants are like any other machine, they are either a benefit or a hazard, if they are a benefit it is not my problem.
  • Re: (Score:2, Insightful)

    Comment removed based on user account deletion
  • Why this is good (Score:5, Insightful)

    by Ubi_NL ( 313657 ) <joris.benschop@g ... Ecom minus punct> on Friday April 05, 2002 @07:13AM (#3289658) Journal
    First of all: I do not believe this is actually true. Antinori really isn't better at cloning then the Roslin Institute [bbsrc.ac.uk], and they usually have a few hundred miscarriages for every successful pregnancy. Presuming Antinori did not have a few hundred women standing by to be impregnated, he really is very lucky to have a 100% success rate.

    But anyway: Let's just assume this is an actual clone. Evidence is now coming through showing that dolly isn't quite as healty as we first expected.
    Apparently she ages a lot faster [newscientist.com], and has a number of diseases [theglobeandmail.com]. Now imagine that, when the baby is born ('prototype clone'), (s)he starts getting all types of horrible diseases, limbs missing and what have you. That is when Joe Schmoe will understand you just can't copy people like you can copy a CD [slashdot.org]. Too bad someone has to suffer for it.
    • Have you read the article?
      He has 500 women available for his experience! I am pretty sure he had his share of failure, miscarriage, abortion...

      Nowhere is it said he has 100% rate, on the contrary. The first weeks are the one where he is most likely to have trouble, so after 8 weeks, chances are good that the baby is healthy and will get to term...

      • so after 8 weeks, chances are good that the baby is healthy and will get to term

        Chances still aren't "good" that the baby will go to term. If success is only 1% likely (according to the BBC interview someone posted), then even if 75% of the embryos terminate in the first eight weeks (which is just what I recall), that means that only 1%/25% = 4% of the remaining embryos go to term. I wouldn't call those odds "good".

        As far as being healthy; of the animals cloned so far I believe the healthy total - Dolly was about as healthy as they come - is more like 0%.

        That said, it's entirely possible that they have an eight-week old clonal embryo; for one thing, the success rate in humans may be higher than in other species; everyone is keen to point out that it might be lower but we don't know. If the baby is brought to term I'd want to see genetic tests to prove it was really a clone, of course.

        In any case, this is monstrous. The babies are likely to be deformed, and this should be stopped immediately.
        • Methink you have got you math and your figures wrong!
          The 1% success rate is for implant/early miscarriage... The actual success rate you want to use is 75%. This is IMHO a good chance.

          Do you really think that at 8 weeks they would still have not detected big anomalie? He has 500 guinea pigs to play with. The 99% failures were seen on other people. You can bet there has been hundreds of early failure, miscarriage to get to that one 75% chance.

        • Just an add-on to make it absolutely clear that I believe the baby will be unhealthy. But it will be born and technically will be a clone (same DNA.)
          Like Dolly has proven there is still much we ignore about cloning and it's consequences. Life is more than just DNA and the women who participate in the experience are in for a big disappointment. They will get their baby alright, but this will be more of a Dr Frankenstein kind of story...

  • by WolfWithoutAClause ( 162946 ) on Friday April 05, 2002 @07:13AM (#3289660) Homepage
    With Dolly the sheep, the 'failure rate' was running at over 150:1 success.

    The failure rate was mostly failures to implant, spontaneous abortions as well as some very deformed births; mostly some that died in a few days, and some that were euthanised.

    If this translates into humans in the same way, for every successful clone we can expect several deformed, live, births.But there are questions as to whether Dolly is really 'successful'; the sheep is suffering from arthritis at an unusually young age for example. If you accept this as a cloning problem, then the failure rate runs at 100%.

    Ignoring the ethics of successful cloning; given this deformation rate, given we do not allow euthenasia of human infants; is this really ethical right now?
    • The failure rate was mostly failures to implant, spontaneous abortions as well as some very deformed births; mostly some that died in a few days, and some that were euthanised.

      Well, I guess the failure to implant is not relevant anymore! So goes spontaneous abortion and deformed birth (you can do most viability tests at 8 weeks.) Remember, he has 500 women to 'play' with so I am sure he has got already is fair share of failure.
      But then, I agree about this not being ethical... The baby is most likely to be born with some anomalies (like Dolly has) and doing that to a human being is wrong. Just plain wrong!

      • >So goes spontaneous abortion

        Some of the abortions occured unusually late IRC.

        >and deformed birth (you can do most viability tests at 8 weeks.)

        One sheep came out looking perfectly normal, but it was panting all the time. They decided it was better to euthenise it.

        What about mental issues? What about subtle immune problems? The number of things that can go wrong and make the kids life hell and yet be completely undetectable are pretty scary.
        • Yes, I should have made it more clear in my post. There is no way the baby is going to be healthy and there is still about 25% chance that it will not come to term.

          I believe that you would have to be a monster to be willing to conceive a baby that way, and that you are surely headed for trouble (big time.) All I wanted to point out is that the chances very fairly good (about 75%) that this baby will come to term. But it surely won't be healthy!!!

  • by nagora ( 177841 ) on Friday April 05, 2002 @07:14AM (#3289663)
    The evidence from the sheep is that any child born this way will have some signs of accelerated aging fairly quickly, so the only reason to do this is the vanity of the researcher and the parents. No one would appear to give a shit about the ethics as long as there's money in it.

    Prison should beckon for all involved.

    TWW

  • What would the Pope say?
    La vita no e bella
    Cloning humans bad
  • Uh oh.... (Score:4, Funny)

    by DohDamit ( 549317 ) on Friday April 05, 2002 @07:48AM (#3289733) Homepage Journal
    Looks likes its confirmed: slashdotters will finally be able to reproduce. Kinda. Of course, I didn't say anything about getting laid....
  • me.clone(); (Score:5, Funny)

    by LadyLucky ( 546115 ) on Friday April 05, 2002 @07:52AM (#3289738) Homepage
    throw new CloneNotSupportedException();
  • by Performer Guy ( 69820 ) on Friday April 05, 2002 @08:25AM (#3289795)
    This announcement has got to be worth a good $15M in ticket receipts for Ep.2.
  • Backups (Score:3, Funny)

    by ZaneMcAuley ( 266747 ) on Friday April 05, 2002 @08:29AM (#3289804) Homepage Journal
    Cool, now I can "back-up" myself :D
  • This Guy is Nuts... (Score:4, Interesting)

    by telstar ( 236404 ) on Friday April 05, 2002 @08:49AM (#3289833)
    "Like atomic energy, cloning can be used for beneficial purposes - to increase population and to open the window of genetic reprogramming." -Dr Antinori
    • And what world currently has an underpopulation problem?
  • by ayjay29 ( 144994 ) on Friday April 05, 2002 @08:59AM (#3289860)
    The DNA for Linus, the well known operating system developer is now available as open source. This has taken the open source movement by storm as the possibilities of Linus clones become fully realised.

    "Normal operating system developers suffer greatly from obsessive compulsive disorders, which causes many problems with other team members. Now we have access to the DNA for Linus, we are able to determine the causes of these disorders, and develop a fix" said Dr Jeckal, a leading expert in developer cloning.

    Microsoft, who have no plan to make Bill Gates DNA available to the public have been strongly opposed to this idea.

    "Imagine a world where every operating system was designed by a slightly different Bill Gates, each with its own quirks and eccentricities. It would be total chaos."

    Microsoft are currently fighting a court case in which Sun, Oracle, Netscape and RedHat are all demanding access to Bill Gates DNA.

    "How can we possibly compete with Microsoft unless we are able to clone our own version of Bill to run on our projects."

  • Human cloning will destroy the human genome by introducing hideous genetic mutation into the gene pool at an ever increasing rate. We may be able to struggle our way out but "homo-sapiens" will become extinct. So lets come up with a scientific name before the clone geeks do...here are my ideas..

    Homer Sapiens
    HS-V2R1
    Homo-XP
    Homo OhNo
  • by Anonymous Coward on Friday April 05, 2002 @09:35AM (#3289984)
    What are the chances that an individual with fertility problems won't produce a clone which also has fertility problems. What happens when that infertile clone wants to reproduce? What then? I know this 'should' never happen, but if cloning is allowed, who's to stop it? Then again, who's to say if it is right or wrong until cloning is proved a success or failure?

  • It's all just practice!
  • Quote (Score:3, Funny)

    by kruczkowski ( 160872 ) on Friday April 05, 2002 @10:46AM (#3290298) Homepage
    "Like atomic energy, cloning can be used for beneficial purposes - to increase population and to open the window of genetic reprogramming."

    I'll leave it to you to comment on that.
  • selling out (Score:2, Insightful)

    by f00zbll ( 526151 )
    This could cause some huge legal problems. Say hypothetically an attractive poor girl decides to sell her genes to a greedy corporation. The corporation then decides to use the DNA to clone her. The clone is raised in a "well adjusted environment," and groomed to be a superstar. The clone now has no rights, since she was purchased, created and programmed (raised) by the company. We now have created exactly what blade runner portrays. How is the creation of slaves any better than all other attempts at slavery throughout the history of humanity?

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