This week the Atlantic published its list of "the 10 Most Promising Breakthrough Innovations of 2022."

"We didn't just get one 'unheard-of' cancer breakthrough; we got several in one year...." Is death reversible? It was this year for several pigs (or, at least, for their organs). By pumping an experimental substance into the veins and arteries of animals that had been lying deceased for an hour, Yale researchers got their hearts to start beating again. The technology is "very far away from use in humans," Stephen Latham, a bioethicist at Yale University, told The New York Times. In the short term, scientists said, they hope that their research could help doctors preserve the organs of the recently deceased for use in transplants. But the longer-term implications of the experiment can't be ignored: If we have the power to reanimate the heart or other organs of the recently deceased, at what point might we be able to reverse sudden deaths? Could we revive soldiers who bleed out on the battlefield? Could we stock hospitals and nursing homes with buckets of the stuff to resuscitate patients? Should every future American household keep some on hand in the event of a terrible accident?

These questions thrust us into the ethical realm and invoke spooky references to "The Monkey's Paw," Pet Sematary, and any number of stories about the dark side of trying to design an escape hatch from mortality. Perhaps, as this technology improves, that debate is on its way. But for millions of people who have lost loved ones to, say, a sudden heart attack or stroke, it's not remotely dystopian to imagine an injection that could reverse tragedies long considered irreversible....

The Power to Synthesize Life (Kind Of)
This summer, scientists grew an embryo in a lab without the use of sperm, or eggs, or a womb. It happened to be that of a mouse. But the species is of secondary importance.... Some scientists I consulted for this project said that the results, which were published this year in the science journal Cell, were the most important scientific breakthrough of 2022.

Scientists are not close to turning stem cells into human babies that make their first gasping cries in antiseptic laboratories. But this work does suggest a major leap forward in our ability to grow synthetic organs and more closely research the relationship between embryonic mutations and developmental diseases. As Paul Tesar, a developmental biologist at Case Western Reserve University School of Medicine, told Stat, "As soon as the science starts to move into a place where it's feasible to go from a stem cell population in a Petri dish all the way through to organ development, it's a pretty wild and remarkable time."
The article also notes that NuScale's small nuclear reactors received approval from the U.S. Nuclear Regulatory Commission, and "could be running by the end of the decade." Meanwhile, the start-up Quaise is working on drilling technology "that can vaporize granite with a highly concentrated beam of radio-frequency power. If such a technology became widely available, deep drilling would be commonplace and geothermal energy would be accessible on just about any patch of land. It would be as though humankind conceived of a magic wand that, waved across the Earth, makes any square mile as energy-rich as an oil-gushing stretch of Texas or Saudi Arabia."

The article also suggests one more possibility for the future. "Decades from now, millions of people may actually prefer the consistency and taste of meat that didn't come from an animal, because they'll know what they're buying when a cultivated rib eye is as consistent as an electrical gadget."

"After decades in the shadow of the reigning model for Alzheimer's disease, alternative explanations are finally getting the attention they deserve," writes Quanta magazine — in a 10,000-word update on where we are now: Three decades ago, scientists thought they had cracked the medical mystery of what causes Alzheimer's disease with an idea known as the amyloid cascade hypothesis. It accused a protein called amyloid-beta of forming sticky, toxic plaques between neurons, killing them and triggering a series of events that made the brain waste away.... Decades of work and billions of dollars went into funding clinical trials of dozens of drug compounds that targeted amyloid plaques. Yet almost none of the trials showed meaningful benefits to patients with the disease....

A stream of recent findings has made it clear that other mechanisms may be at least as important as the amyloid cascade as causes of Alzheimer's disease.... The emerging new models of the disease are more complex than the amyloid explanation, and because they are still taking shape, it's not clear yet how some of them may eventually translate into therapies. But because they focus on fundamental mechanisms affecting the health of cells, what's being learned about them might someday pay off in new treatments for a wide variety of medical problems, possibly including some key effects of aging.... While these alternate ideas were once hushed and thrown under the rug, now the field has broadened its attention.
The article explores the theory — derived from research on genetically-engineered mice — that neurons bulging with toxic accumulations of proteins and molecules could be mistaken for classic amyloid plaques outside cells. (But in fact "the extracellular amyloid plaques weren't killing the cells — because the cells were already dead.") Scientists are now also investigating lysosomes, cholesterol metabolism, and even the immune system.

To say that the amyloid hypothesis is dead would be overstating it, said Donald Weaver, a co-director of the Krembil Brain Institute in Toronto, but "I would say that the amyloid hypothesis is insufficient...."

By 2017, 146 drug candidates for treating Alzheimer's disease had been deemed unsuccessful. Only four drugs had been approved, and they treated the symptoms of the disease, not its underlying pathology. The results were so disappointing that in 2018, Pfizer pulled out of Alzheimer's research. A 2021 review that compared the results of 14 of the major trials confirmed that reducing extracellular amyloid did not greatly improve cognition....

The hypothesis took another hit last July when a bombshell article in Science revealed that data in the influential 2006 Nature paper linking amyloid plaques to cognitive symptoms of Alzheimer's disease may have been fabricated. The connection claimed by the paper had convinced many researchers to keep pursuing amyloid theories at the time.

Astronomers searched through 200,000 archival images from Hubble Space Telescope and made tens of thousands of measurements on these images to look for any residual background glow in the sky. Like turning out the lights in a room, they subtracted the light from stars, galaxies, planets and the zodiacal light. Surprisingly, a ghostly, feeble glow was left over. It's equivalent to the steady light of ten fireflies spread across the entire sky. Phys.Org reports: One possible explanation is that a shell of dust envelops our solar system all the way out to Pluto, and is reflecting sunlight. Seeing airborne dust caught in sunbeams is no surprise when cleaning the house. But this must have a more exotic origin. Because the glow is so smoothy distributed, the likely source is innumerable cometsâ"free-flying dusty snowballs of ice. They fall in toward the sun from all different directions, spewing out an exhaust of dust as the ices sublimate due to heat from the sun. If real, this would be a newly discovered architectural element of the solar system. It has remained invisible until very imaginative and curious astronomers, and the power of Hubble, came along. The research papers are published in The Astronomical Journal and The Astrophysical Journal Letters.

One of the great differences between Mars and Earth involves what's going on beneath the surface. Our planet remains a tectonically and volcanically active world -- witness the current eruptions in Hawaii -- while Mars has been a cold, geologically dead place for the past three billion years. That was the thinking at least. But a new paper in Nature Astronomy challenges that accepted wisdom. Mars, it suggests, may still be geologically active today. Time: The findings are the result of orbital photography, surface data, and computer modeling of a lowland region near the Martian equator known as Elysium Planitia -- where NASA's Mars InSight probe landed in 2018. Researchers from the University of Arizona Lunar and Planetary Laboratory analyzed recordings of Mars quakes taken by InSight and concluded that they all result from a series of subsurface fissures dubbed Cerberus Fossae, which stretch nearly 1,300 km (800 mi.) across the Martian surface. This gives rise to what are known as mantle plumes: blob-like masses of molten rock that rise to reach the base of the crust, causing quakes, faulting, and volcanic eruptions. Computer modeling of the region indicates that far from being geologically dead, Elysium Planitia experienced major volcanic eruptions as recently as 200 million years ago.

A three-year-old NASA satellite lost touch with ground controllers two weeks ago and is now wandering through low Earth orbit without supervision. Sadly, the space agency fears the worst. Gizmodo reports: NASA's Ionospheric Connection Explorer (ICON) mission has not communicated with ground stations since November 25 due to some sort of glitch the space agency is yet to identify, NASA wrote in a blog post on Wednesday. The spacecraft is equipped with an onboard command loss timer that's designed to reset ICON in the event that contact is lost for eight days, but the reset seemingly did not work as the team was still unable to communicate with the spacecraft on December 5 after the power cycle was complete.

Although silent, the ICON spacecraft is still intact. NASA used the Department of Defense's Space Surveillance Network to confirm that ICON is still out there in one piece, according to the space agency. But communication is obviously key for orbiting spacecraft, as it allows the mission team to send commands to satellites and also receive data through downlinked signals. "The ICON mission team is working to troubleshoot the issue and has narrowed the cause of the communication loss to problems within the avionics or radio-frequency communications subsystems," NASA wrote in the blog post. "The team is currently unable to determine the health of the spacecraft, and the lack of a downlink signal could be indicative of a system failure." Oof, that doesn't sound good.

A Japanese billionaire picked his crewmates for the first-ever artist-centered mission. Space.com reports: Yusaku Maezawa, who made his fortune as an online fashion retailer, announced the eight people who would be flying with him on the dearMoon mission, which aims to use a SpaceX Starship to fly around the moon as soon as next year. "I hope each and every one will recognize the responsibility that comes with leaving the Earth, travelling to the moon and back," Maezawa says in the video in Japanese, with a translation provided in-video.

Riding along with Maezawa will be:
- Steve Aoki, D.J., producer and electronic dance music artist with several Billboard-charting studio albums;
- Tim Dodd, YouTube creator of the "Everyday Astronaut" channel (Dodd has interviewed SpaceX founder Elon Musk multiple times on camera);
- Yemi A.D., artist and choreographer known for his work with JAD Dance Company and with Ye (formerly Kanye West);
- Karim Iliya, photographer whose publications include National Geographic Magazine;
- Rhiannon Adam, a photographer who has been supported by the BBC/Royal Geographical Society and won multiple awards, according to their website;
- Brendan Hall, filmmaker on projects such as the two-hour documentary "Blood Sugar Rising" about diabetes in the United States, according to the Internet Movie Database;
- Dev Joshi, an "Indian television actor known for portraying the role of Baal Veer in Sony Sab's Baal Veer and Baalveer Returns," according to the Internet Movie Database;
- T.O.P., a South Korean rapper known as the lead for the boy band Big Bang;
- Two backup members: dancer Miyu, and snowboarder Kaitlyn Farrington.

Each member of the dearMoon crew was briefly quoted in a video from the dearMoon YouTube channel, and the announcement was confirmed on Dodd's and Maezawa's Twitter feeds.

An anonymous reader quotes a report from CNBC: Former Theranos chief operating officer and president Ramesh "Sunny" Balwani was sentenced to nearly 13 years in prison Wednesday for fraud, after the unraveling of the blood-testing juggernaut prompted criminal charges in California federal court against both Balwani and Theranos founder Elizabeth Holmes, who on Nov. 18 was sentenced to more than 11 years in prison.

During the sentencing hearing, attorneys for Balwani attempted to pin the blame on Holmes, telling U.S. District Court Judge Edward J. Davila that "decisions were made by Elizabeth Holmes." Davila had set a sentencing range of 11 years plus 3 months to 14 years, but prosecutors today sought a 15-year sentence given his "significant" oversight role at Theranos' lab business. The final guideline sentence was 155 months, plus three years of probation. Davila set a Mar. 15, 2023, surrender date. [...] Balwani's sentencing in federal court marks the end of the Theranos saga, which enthralled the public and prompted documentary films and novel treatments.

Two studies published Tuesday in the journal Nature Communications found a link between several types of bacteria in the gut and depressive symptoms. The first study, titled "Gut microbiome-wide association study of depressive symptoms," reports: Here we investigate the relation of fecal microbiome diversity and composition with depressive symptoms in 1,054 participants from the Rotterdam Study cohort and validate these findings in the Amsterdam HELIUS cohort in 1,539 subjects. We identify association of thirteen microbial taxa, including genera Eggerthella, Subdoligranulum, Coprococcus, Sellimonas, Lachnoclostridium, Hungatella, Ruminococcaceae (UCG002, UCG003 and UCG005), LachnospiraceaeUCG001, Eubacterium ventriosum and Ruminococcusgauvreauiigroup, and family Ruminococcaceae with depressive symptoms. These bacteria are known to be involved in the synthesis of glutamate, butyrate, serotonin and gamma amino butyric acid (GABA), which are key neurotransmitters for depression. Our study suggests that the gut microbiome composition may play a key role in depression. The second study, titled "The gut microbiota and depressive symptoms across ethnic groups," reports: Both the microbiome and depressive symptom levels vary substantially across ethnic groups. Thus, any intervention for depression targeting the microbiome requires understanding of microbiome-depression associations across ethnicities. Analyzing data from the HELIUS cohort, we characterize the gut microbiota and its associations with depressive symptoms in 6 ethnic groups (Dutch, South-Asian Surinamese, African Surinamese, Ghanaian, Turkish, Moroccan; N=3211), living in the same urban area. Diversity of the gut microbiota, both within (a-diversity) and between individuals (B-diversity), predicts depressive symptom levels, taking into account demographic, behavioural, and medical differences. These associations do not differ between ethnic groups. Further, B-diversity explains 29%-18% of the ethnic differences in depressive symptoms. Bacterial genera associated with depressive symptoms belong to mulitple families, prominently including the families Christensenellaceae, Lachnospiraceae, and Ruminococcaceae. In summary, the results show that the gut microbiota are linked to depressive symptom levels and that this association generalizes across ethnic groups. Moreover, the results suggest that ethnic differences in the gut microbiota may partly explain parallel disparities in depression. The Wall Street Journal shared (paywalled) the findings.

An anonymous reader shares an excerpt from an opinion piece in Scientific American, written by Jason Wright. Wright is a professor of astronomy and astrophysics at Pennsylvania State University, where he is director of the Penn State Extraterrestrial Intelligence Center. From the piece: In August the White House announced (PDF) that the results of all federally funded research should be freely accessible by the end of 2025. This will be a big change for scientists in many fields but ultimately a good move for the democratization of research. Under this new guidance, many peer-reviewed papers would be free for the world to read immediately upon publication rather than stuck behind expensive paywalls, and the data that underlay these papers would be fully available and properly archived for anyone who wanted to analyze them. As an astronomer, I'm pleased that our profession has been ahead of the curve on this, and most of the White House's recommendations are already standard in our field.

NASA, as a federal agency that funds and conducts research, is onboard with the idea of freely accessible data. But it has a plan that goes much further than the White House's and that is highly problematic. The agency currently gives a proprietary period to some scientists who use particular facilities, such as a 12-month period for the powerful James Webb Space Telescope (JWST), so that those scientists can gather and analyze data carefully without fear of their work being poached. NASA is looking to end this policy in its effort to make science more open-access. Losing this exclusivity would be really bad for astronomy and planetary science. Without a proprietary period, an astronomer with a brilliant insight might spend years developing it, months crafting a successful proposal to execute it, and precious hours of highly competitive JWST time to actually perform the observations -- only to have someone else scoop up the data from a public archive and publish the result. This is a reasonable concern -- such scooping has happened before.

Without a proprietary period during which the astronomers who proposed given observations have exclusive access to the data, those researchers will have to work very quickly in order to avoid being scooped. Receiving credit for discoveries is especially important for early-career astronomers looking to establish their credentials as they search for a permanent job. Under such time pressure, researchers will need to cut corners, such as skipping the checks and tests that define careful work. Such a sloppy approach will lead to hasty results and incorrect conclusions to the detriment of the entire field. It also can lead to the erosion of work-life boundaries, with astronomers working long hours, sacrificing their health and family time so their result gets out before the competition's. This is bad for the culture of science and disproportionately affects those with children or other time-consuming personal circumstances (such as being a student, a caretaker or a full-time college instructor while also performing research). Allowing researchers to properly benefit from their work is critical for making astronomy as fair and equitable as possible. [...] "One potential alternative is to create a professional requirement that those who proposed an observation but have not published from it should be offered co-authorship on any paper that uses the data," suggests Wright, noting that it's "not currently the cultural norm in astronomy" and "comes with a whole host of complications."

"Another option is to change the standard for how credit is assigned for any observational work," adds Wright. "Astronomers could, for example, demand that any paper citing a result also cite the proposal that generated the enabling data. In this way, the proposal team could still accrue credit for its work, even if it wasn't the first to publish."

"In the end, though, such adjustments are secondary to the heart of the matter, which is that NASA's plan to eliminate the proprietary period for JWST data is bad for astronomy."

Construction of the world's largest radio astronomy observatory, the Square Kilometre Array, has officially begun in Australia after three decades in development. From a report: A huge intergovernmental effort, the SKA has been hailed as one of the biggest scientific projects of this century. It will enable scientists to look back to early in the history of the universe when the first stars and galaxies were formed. It will also be used to investigate dark energy and why the universe is expanding, and to potentially search for extraterrestrial life. The SKA will initially involve two telescope arrays -- one on Wajarri country in remote Western Australia, called SKA-Low, comprising 131,072 tree-like antennas. SKA-Low is so named for its sensitivity to low-frequency radio signals. It will be eight times as sensitive than existing comparable telescopes and will map the sky 135 times faster. A second array of 197 traditional dishes, SKA-Mid, will be built in South Africa's Karoo region.

It began decades ago, with a few hardy pioneers slogging north across the tundra. It's said that one individual walked so far to get there that he rubbed the skin off the underside of his long, flat tail. Today, his kind have homes and colonies scattered throughout the tundra in Alaska and Canada -- and their numbers are increasing. Beavers have found their way to the far north. From a report: It's not yet clear what these new residents mean for the Arctic ecosystem, but concerns are growing, and locals and scientists are paying close attention. Researchers have observed that the dams beavers build accelerate changes already in play due to a warming climate. Indigenous people are worried the dams could pose a threat to the migrations of fish species they depend on.

"Beavers really alter ecosystems," says Thomas Jung, senior wildlife biologist for Canada's Yukon government. In fact, their ability to transform landscapes may be second only to that of humans: Before they were nearly extirpated by fur trappers, millions of beavers shaped the flow of North American waters. In temperate regions, beaver dams affect everything from the height of the water table to the kinds of shrubs and trees that grow. Until a few decades ago, the northern edge of the beaver's range was defined by boreal forest, because beavers rely on woody plants for food and material to build their dams and lodges. But rapid warming in the Arctic has made the tundra more hospitable to the large rodents: Earlier snowmelt, thawing permafrost and a longer growing season have triggered a boom in shrubby plants like alder and willow that beavers need. Aerial photography from the 1950s showed no beaver ponds at all in Arctic Alaska. But in a recent study, Ken Tape, an ecologist at the University of Alaska Fairbanks, scanned satellite images of nearly every stream, river and lake in the Alaskan tundra and found 11,377 beaver ponds.

Marc Tessier-Lavigne is president of Stanford University. He's also "the subject of a university investigation," reports SFGate, "following a report from the school's newspaper, the Stanford Daily, that he committed scientific research misconduct" in papers he co-authored years ago which may contain altered images.

More from the Washington Post: The university launched the inquiry after the Stanford Daily, a campus newspaper, reported that a well-known research journal was looking into concerns raised about a 2008 paper co-authored by Marc Tessier-Lavigne. The Daily reported that in addition to the paper in the European Molecular Biology Organization Journal, there were questions about other published research.

Some of those complaints were first made many years ago, and Tessier-Lavigne had tried to correct papers at one journal in 2015, according to its editor.... Tessier-Lavigne said in a statement that he supports the inquiry. "Scientific integrity is of the utmost importance both to the university and to me personally," Tessier-Lavigne said. "I support this process and will fully cooperate with it, and I appreciate the oversight by the Board of Trustees...."

Elisabeth Bik, who had been a staff scientist at Stanford doing postdoctoral microbiology research until 2016 and is now a well-known research integrity consultant who specializes in photographic images, said she heard about the questions about some papers of which Tessier-Lavigne is one of the authors a few years after they were first raised, and identified additional possible problems.

Most appeared to be minor concerns, and they could have been honest mistakes, she said. This week, Bik said, she spotted a more troubling instance in a paper from 1999 with multiple authors where it appeared photos had been altered, which she said was suggestive of copying and pasting.
The Los Angeles Times describes Tessier-Lavigne as "a neuroscientist and biotech entrepreneur widely known for his Alzheimer's research" who "has authored or co-authored about 300 scientific papers."

"In an experiment that ticks most of the mystery boxes in modern physics, a group of researchers announced Wednesday that they had simulated a pair of black holes in a quantum computer," reports the New York Times [alternate URL here. But in addition, the researchers also sent a message between their two black holes, the Times reports, "through a shortcut in space-time called a wormhole.

"Physicists described the achievement as another small step in the effort to understand the relation between gravity, which shapes the universe, and quantum mechanics, which governs the subatomic realm of particles....

Quanta magazine reports: The wormhole emerged like a hologram out of quantum bits of information, or "qubits," stored in tiny superconducting circuits. By manipulating the qubits, the physicists then sent information through the wormhole, they reported Wednesday in the journal Nature. The team, led by Maria Spiropulu of the California Institute of Technology, implemented the novel "wormhole teleportation protocol" using Google's quantum computer, a device called Sycamore housed at Google Quantum AI in Santa Barbara, California. With this first-of-its-kind "quantum gravity experiment on a chip," as Spiropulu described it, she and her team beat a competing group of physicists who aim to do wormhole teleportation with IBM and Quantinuum's quantum computers.

When Spiropulu saw the key signature indicating that qubits were passing through the wormhole, she said, "I was shaken."

The experiment can be seen as evidence for the holographic principle, a sweeping hypothesis about how the two pillars of fundamental physics, quantum mechanics and general relativity, fit together.... The holographic principle, ascendant since the 1990s, posits a mathematical equivalence or "duality" between the two frameworks. It says the bendy space-time continuum described by general relativity is really a quantum system of particles in disguise. Space-time and gravity emerge from quantum effects much as a 3D hologram projects out of a 2D pattern. Indeed, the new experiment confirms that quantum effects, of the type that we can control in a quantum computer, can give rise to a phenomenon that we expect to see in relativity — a wormhole....

To be clear, unlike an ordinary hologram, the wormhole isn't something we can see. While it can be considered "a filament of real space-time," according to co-author Daniel Jafferis of Harvard University, lead developer of the wormhole teleportation protocol, it's not part of the same reality that we and the Sycamore computer inhabit. The holographic principle says that the two realities — the one with the wormhole and the one with the qubits — are alternate versions of the same physics, but how to conceptualize this kind of duality remains mysterious. Opinions will differ about the fundamental implications of the result. Crucially, the holographic wormhole in the experiment consists of a different kind of space-time than the space-time of our own universe. It's debatable whether the experiment furthers the hypothesis that the space-time we inhabit is also holographic, patterned by quantum bits.

"I think it is true that gravity in our universe is emergent from some quantum [bits] in the same way that this little baby one-dimensional wormhole is emergent" from the Sycamore chip, Jafferis said. "Of course we don't know that for sure. We're trying to understand it."
Here's how principal investigator Spiropulu summarizes their experiment. "We found a quantum system that exhibits key properties of a gravitational wormhole yet is sufficiently small to implement on today's quantum hardware."

"Maintenance of the software that's used for the hardest physics calculations rests almost entirely with a retiree," reports Quanta magazine, saying the situation "reveals the problematic incentive structure of academia." Particle physicists use some of the longest equations in all of science. To look for signs of new elementary particles in collisions at the Large Hadron Collider, for example, they draw thousands of pictures called Feynman diagrams that depict possible collision outcomes, each one encoding a complicated formula that can be millions of terms long. Summing formulas like these with pen and paper is impossible; even adding them with computers is a challenge. The algebra rules we learn in school are fast enough for homework, but for particle physics they are woefully inefficient.

Programs called computer algebra systems strive to handle these tasks. And if you want to solve the biggest equations in the world, for 33 years one program has stood out: FORM. Developed by the Dutch particle physicist Jos Vermaseren, FORM is a key part of the infrastructure of particle physics, necessary for the hardest calculations. However, as with surprisingly many essential pieces of digital infrastructure, FORM's maintenance rests largely on one person: Vermaseren himself. And at 73, Vermaseren has begun to step back from FORM development. Due to the incentive structure of academia, which prizes published papers, not software tools, no successor has emerged. If the situation does not change, particle physics may be forced to slow down dramatically...

Without ongoing development, FORM will get less and less usable — only able to interact with older computer code, and not aligned with how today's students learn to program. Experienced users will stick with it, but younger researchers will adopt alternative computer algebra programs like Mathematica that are more user-friendly but orders of magnitude slower. In practice, many of these physicists will decide that certain problems are off-limits — too difficult to handle. So particle physics will stall, with only a few people able to work on the hardest calculations.

In April, Vermaseren is holding a summit of FORM users to plan for the future. They will discuss how to keep FORM alive: how to maintain and extend it, and how to show a new generation of students just how much it can do. With luck, hard work and funding, they may preserve one of the most powerful tools in physics.
Thanks to long-time Slashdot reader g01d4 for submitting the story.

An anonymous reader quotes a report from Ars Technica: Last month, a Texas-based company announced that it had successfully deployed the largest-ever commercial communications satellite in low-Earth orbit. This BlueWalker 3 demonstration satellite measures nearly 65 square meters, or about one-third the size of a tennis court. Designed and developed by AST SpaceMobile, the expansive BlueWalker 3 satellite is intended to demonstrate the ability of standard mobile phones to directly connect to the Internet via satellite. Large satellites are necessary to connect to mobile devices without a ground-based antenna. [...] Since BlueWalker3's launch in September, astronomers have been tracking the satellite, and their alarm was heightened following its antenna deployment last month. According to the International Astronomical Union, post-deployment measurements showed that BlueWalker 3 had an apparent visual magnitude of around 1 at its brightest, which is nearly as bright as Antares and Spica, the 15th and 16th brightest stars in the night sky.

For a few years, astronomers have been expressing concerns about megaconstellations, such as SpaceX's Starlink satellites. While these are more numerous -- there are more than 3,000 Starlink satellites in orbit -- they are much smaller and far less bright than the kinds of satellites AST plans to launch. Eventually, AST plans to launch a constellation of 168 large satellites to provide "substantial" global coverage, a company spokesperson said. Even one is enough for astronomers, however. "BlueWalker 3 is a big shift in the constellation satellite issue and should give us all reason to pause," said Piero Benvenuti, a director at the International Astronomical Union.

The organization of astronomers is also concerned about the potential for radio interference from these "cell phone towers in space." They will transmit strong radio waves at frequencies currently reserved for terrestrial cell phone communications but are not subject to the same radio quiet zone restrictions that ground-based cellular networks are. This could severely impact radio astronomy research -- which was used to discover cosmic microwave background radiation, for example -- as well as work in related fields. Astronomers currently build their radio astronomy observatories in remote areas, far from cell tower interference. They are worried that these large, radio-wave transmitting satellites will interfere in unpopulated areas. "We are eager to use the newest technologies and strategies to mitigate possible impacts to astronomy," AST said in a statement to Ars. "We are actively working with industry experts on the latest innovations, including next-generation anti-reflective materials. We are also engaged with NASA and certain working groups within the astronomy community to participate in advanced industry solutions, including potential operational interventions."

AST is "committed to avoiding broadcasts inside or adjacent to the National Radio Quiet Zone in the United States [...] as well as additional radioastronomy locations," adds Ars.

Scientists hoping to harness nuclear fusion -- the same energy source that powers the Sun and other stars -- have confirmed that magnetic fields can enhance the energy output of their experiments, reports a new study. The results suggest that magnets may play a key role in the development of this futuristic form of power, which could theoretically provide a virtually limitless supply of clean energy. Motherboard reports: Fusion power is generated by the immense energy released as atoms in extreme environments merge together to create new configurations. The Sun, and all the stars in the night sky, are fueled by this explosive process, which occurs in their cores at incredibly high temperatures and pressures. Scientists have spent roughly a century unraveling the mechanics of nuclear fusion in nature, and trying to artificially replicate this starry mojo in laboratories. Now, a team at the National Ignition Facility (NIF), which is a fusion experiment based at the U.S. Department of Energy's Lawrence Livermore National Laboratory, has reported that the magnetic fields can boost the temperature of the fusion "hot spot" in experiments by 40 percent and more than triple its energy output, which is "approaching what is required for fusion ignition" according to a study published this month in Physical Review Letters.

"The magnetic field comes in and acts kind of like an insulator," said John Moody, a senior scientist at the NIF who led the study, in a call with Motherboard. "You have what we call the hot spot. It's millions of degrees, and around it is just room temperature. All that heat wants to flow out because heat always goes from the hot to the cold and the magnetic field prevents that from happening." "When we go in and we put the magnetic field on this hotspot, and we insulate it, now that heat stays in there, and so we're able to get the hot spot to a higher temperature," he continued. "You get more [fusion] reactions as you go up in temperature, and that's why we see this improvement in the reactivity."

The hot spots in the NIF's fusion experiments are created by shooting nearly 200 lasers at a tiny pellet of fuel made of heavier isotopes (or versions) of hydrogen, such as deuterium and tritium. These laser blasts generate X-rays that make the small capsule implode, producing the kinds of extreme pressures and temperatures that are necessary for the isotopes to fuse together and release their enormous stores of energy. NIF has already brought their experiments to the brink of ignition, which is the point at which fusion reactions become self-sustaining in plasmas. The energy yields created by these experiments are completely outweighed by the energy that it takes to make these self-sustaining reactions in the plasmas in the first place. Still, achieving ignition is an important step toward creating a possible "breakeven" system that produces more energy output than input. Moody and his colleagues developed their magnetized experiment at NIF by wrapping a coil around a version of the pellet made with specialized metals.

The Viking 1 lander arrived on the Martian surface 46 years ago to investigate the planet. It dropped down into what was thought to be an ancient outflow channel. Now, a team of researchers believes they've found evidence of an ancient megatsunami that swept across the planet billions of years ago, less than 600 miles from where Viking landed. Gizmodo reports: In a new paper published today in Scientific Reports, a team identified a 68-mile-wide impact crater in Mars' northern lowlands that they suspect is leftover from an asteroid strike in the planet's ancient past. "The simulation clearly shows that the megatsunami was enormous, with an initial height of approximately 250 meters, and highly turbulent," said Alexis Rodriguez, a researcher at the Planetary Science Institute and lead author of the paper, in an email to Gizmodo. "Furthermore, our modeling shows some radically different behavior of the megatsunami to what we are accustomed to imagining."

Rodriguez's team studied maps of the Martian surface and found the large crater, now named Pohl. Based on Pohl's position on previously dated rocks, the team believes the crater is about 3.4 billion years old -- an extraordinarily long time ago, shortly after the first signs of life we know of appeared on Earth. According to the research team's models, the asteroid impact could have been so intense that material from the seafloor may have dislodged and been carried in the water's debris flows. Based on the size of the crater, the team believes the impacting asteroid could have been 1.86 miles wide or 6 miles wide, depending on the amount of ground resistance the asteroid encountered. The impact could have released between 500,000 megatons and 13 million megatons of TNT energy (for comparison, the Tsar Bomba nuclear test was about 57 megatons of TNT energy.) "A clear next step is to propose a landing site to investigate these deposits in detail to understand the ocean's evolution and potential habitability," Rodriguez said. "First, we would need a detailed geologic mapping of the area to reconstruct the stratigraphy. Then, we need to connect the surface modification history to specific processes through numerical modeling and analog studies, including identifying possible mud volcanoes and glacier landforms."

An anonymous reader quotes a report from Motherboard: Motility -- the scientific term for being able to move independently -- is one of the most important features for living organisms on Earth. But where cells' ability to move came from has been a mystery for many scientists. However, new research in which scientists created the world's smallest moving organism provides one idea of how cell motility came to be. As the authors write in their paper, "motility is observed in various phyla and arguably one of the major determinants of survival." According to the paper, cell motility is believed to originate from small movements of housekeeping proteins that are transmitted to a cell, but the proposed process hasn't been experimentally demonstrated. Their study is thus a way to test out this theory.

In this experiment, the researchers genetically engineered a synthetic bacterium named JCVI-syn-3b, or syn-3, which is non-motile. To reconstitute syn-3, the group introduced seven genes that code for proteins that are likely involved in the swimming motion of Spiroplasma bacteria. Spiroplasma is a small bacteria known to "swim" by essentially switching around its cytoskeleton. The proteins introduced evolved from the bacterial actin protein MreB. Actin are multi-functional proteins that are often responsible for motility in cells. In an email to Motherboard, Miyata confirmed that prior to this experiment, nobody had succeeded in making a motile minimal synthetic bacterium. By introducing the proteins responsible for motility in Spiroplasma into syn-3, the researchers were able to make the previously non-motile bacteria swim, as evident in a video published on the University's YouTube account.

The researchers also wanted to see how the expression of different combinations of the motility genes would affect the genetically engineered bacteria to swim. In doing so, they found that the expression of only two proteins was necessary for promoting motility in syn-3, likely indicating that many of the proteins were redundant and demonstrating a minimal system for motility. "To the best of our knowledge, the motility system comprising only two actin superfamily proteins is the smallest system established till date," the authors write. "Therefore, we may call this a 'minimal motile cell.'" Although this study is primarily a proof of concept, it gives scientists a better understanding of how cell motility could have potentially originated and evolved. "In addition to the sheer novelty of creating such a smol swimmer, the new study sheds light on the origin of movement in the first mobile lifeforms that arose on Earth," adds Motherboard. "For instance, Miyata said that the actin protein MreB is not involved in the motility of many other bacterial species, which confirms that there are multiple different evolutionary pathways that led to microbial movement."

The study has been published in the journal Science Advances.

An anonymous reader quotes a report from The Guardian: The brains of teenagers who lived through the Covid pandemic show signs of premature aging, research suggests. The researchers compared MRI scans of 81 teens in the US taken before the pandemic, between November 2016 and November 2019, with those of 82 teens collected between October 2020 and March 2022, during the pandemic but after lockdowns were lifted. After matching 64 participants in each group for factors including age and sex, the team found that physical changes in the brain that occurred during adolescence -- such as thinning of the cortex and growth of the hippocampus and the amygdala -- were greater in the post-lockdown group than in the pre-pandemic group, suggesting such processes had sped up. In other words, their brains had aged faster.

"Brain age difference was about three years -- we hadn't expected that large an increase given that the lockdown was less than a year [long]," said Ian Gotlib, a professor of psychology at Stanford University and first author of the study. Writing in the journal Biological Psychiatry: Global Open Science, the team report that the participants -- a representative sample of adolescents in the Bay Area in California -- originally agreed to take part in a study looking at the impact of early life stress on mental health across puberty. As a result, participants were also assessed for symptoms of depression and anxiety. The post-lockdown group self-reported greater mental health difficulties, including more severe symptoms of anxiety, depression and internalizing problems. "Deterioration in mental health is accompanied by physical changes in the brain for teens, likely due to the stress of the pandemic," said Gotlib.

"In older adults, these brain changes are often association with reduced cognitive functioning. It's not clear yet what they mean in adolescents. But this is the first demonstration that difficulties in mental health during the pandemic are accompanied by what seem to be stress-related changes in brain structure."

Five years ago, a study describing a precipitous decline in sperm counts sparked extreme concerns that humanity was on the path to extinction. Now a new study shows that sperm counts have fallen further and the rate of decline is speeding up, raising fears of a looming global fertility crisis. From a report: The initial study, published in July 2017, revealed that sperm counts -- the number of sperm in a single ejaculate -- plummeted by more than 50 percent among men in North America, Europe, Australia, and New Zealand between 1973 and 2011. Since then, a team led by the same researchers has explored what has happened in the last 10 years. In a new meta-analysis, which appeared in the journal Human Reproduction Update, researchers analyzed studies of semen samples published between 2014 and 2019 and added this to their previous data. The newer studies have a more global perspective and involved semen samples from 14,233 men, including some from South and Central America, Africa, and Asia. The upshot: Not only has the decline in total sperm counts continued -- reaching a drop of 62 percent -- but the decline per year has doubled since 2000. The 2017 report also revealed that sperm concentration (the number of sperm per milliliter of semen) dropped by an average of 1.6 percent per year, totaling more than a 52 percent among men in these regions over the previous four decades.