"To date, about 500 people have been put in cryogenic stasis after legal death," writes a Bloomberg Opinion technology columnist, "with the majority of them in the U.S.

"But a few thousand more, including Emil Kendziorra, are on waiting lists, wearing bracelets or necklaces with instructions for emergency responders. " Kendziorra, 36, runs Berlin-based Tomorrow Biostasis GmbH, one of the first cryonics businesses in Europe to join a market dominated by American firms organizations like The Alcor Life Extension Foundation and The Cryonics Institute. The former cancer doctor has several hundred people on his firm's waiting list. They skew to their late 30s, male and tend to work in technology. Patients can choose to have their entire body preserved and held upside down in a four-person dewars, a thermos-like aluminum vat filled with liquid nitrogen, or just preserve their brain, which is cheaper.

Kendziorra says cryopreservation overall has become less expensive over the past few decades on an inflation-adjusted basis, a claim that he bases on historic prices published by his peers, who he says are making a collective effort to bring down costs. That could be critical to shifting cryonics from a fringe pursuit to something a little more mainstream, especially since it is no longer just for billionaires like PayPal Inc. co-founder Peter Thiel (who has reportedly signed up with Alcor). Kendziorra, for instance, has made cryonics just another monthly subscription by capitalizing on insurance, he told me during a Twitter Spaces discussion on cryonics last month. His customers pay a 25-euro ($26.54) monthly fee to Tomorrow Biostasis, and they also make the company the beneficiary of a minimum 100,000-euro life insurance payout upon their legal death. Kendziorra says that covers the full cost of cryonics including the biggest outlay: maintenance over the next century or so.

All told, most of his customers are paying about 50 euros a month for both the company's subscription fee and the life insurance policy for the option of a long sleep at death. Of course, most companies don't survive for more than a century, so Tomorrow Biostasis also partners with a non-profit group in Switzerland to carry out the storage of customers on its behalf.... The domain itself is largely funded by wealthy individuals including CEOs of tech companies, angel investors and scientists, Kendziorra says, adding that for them to invest in his own firm, their primary motivation shouldn't be "monetary" but rather to help further the field.

The mechanics all sound sensible, but that still leaves the question of whether cryonics will work, medically speaking. Doctors and scientists have used words like quackery, pseudoscience and outright fraud to describe the field. Clive Cohen, a neuroscientist from Kings College London, has called it a "hopeless aspiration that reveals an appalling ignorance of biology." The Association of Cryobiology has compared it to turning a hamburger back into a cow.

"Wheat now provides 20% of the calories consumed by humans every day," writes the Guardian. Unfortunately, "Thanks to human-induced global heating, our planet faces a future of increasingly severe heat waves, droughts and wildfires that could devastate harvests in future, triggering widespread famine in their wake.

"But the crisis could be averted thanks to remarkable research now being undertaken by researchers at the John Innes Centre in Norwich." They are working on a project to make wheat more resistant to heat and drought. Such efforts have proved to be extremely tricky but are set to be the subject of a new set of trials in a few weeks as part of a project in which varieties of wheat — created, in part, by gene-editing technology — will be planted in field trials in Spain. The ability of these varieties to withstand the heat of Iberia will determine how well crop scientists will be able to protect future arable farms from the worst vicissitudes of climate change, and so bolster food production for the Earth's billions, says the John Innes Centre team....

"A key tool in this work was gene editing, which allowed us to make precise changes in wheat DNA. Without it, we would still be struggling with this. It has made all the difference."
This was an especially difficult struggle because wheat genetics includes multiple ancestral genomes, the article points.

Thanks to long-time Slashdot reader schwit1 for submitting the story.

"Aboard the International Space Station right now is a metal box, the size of a desktop PC tower," reports Popular Mechanics. "Inside, a nozzle is helping build little test parts that aren't possible to make on Earth."

The Washington Post reports: Backed by MIT's Space Exploration Initiative, astronauts on board the International Space Station on Friday completed a roughly 45-day experiment using a small microwave-sized box that injects resin into silicone skins to build parts, such as nuts and bolts. Now, after the parts travel back to Earth this weekend, scientists will evaluate the test pieces to examine whether they were made successfully — a process that could take weeks.

If so, it paves the way for astronauts to build huge parts that would be nearly impossible on Earth thanks to gravity and could upgrade space construction.It lets you build and modify space stations "quicker, cheaper and with less complexity," said Ariel Ekblaw, the founder of the Space Exploration Initiative. "It starts to unlock more opportunities for exploration."
The silicone skin is like a balloon filled with resin instead of air, an MIT engineer/researcher told Popular Science — with the resin then cured and solidified by a flash of ultraviolet light. (After which astronauts can cut away the silicone skin.)

The best part? The skin and the resin are both readily available off-the-shelf products.

Researchers have spent decades trying to figure out how ancient Romans were able to make concrete that's survived for two millennia. "Now, a team of investigators from MIT, Harvard University, and laboratories in Italy and Switzerland, has made progress in this field, discovering ancient concrete-manufacturing strategies that incorporated several key self-healing functionalities," reports MIT News. From the report: For many years, researchers have assumed that the key to the ancient concrete's durability was based on one ingredient: pozzolanic material such as volcanic ash from the area of Pozzuoli, on the Bay of Naples. This specific kind of ash was even shipped all across the vast Roman empire to be used in construction, and was described as a key ingredient for concrete in accounts by architects and historians at the time. Under closer examination, these ancient samples also contain small, distinctive, millimeter-scale bright white mineral features, which have been long recognized as a ubiquitous component of Roman concretes. These white chunks, often referred to as "lime clasts," originate from lime, another key component of the ancient concrete mix.

Previously disregarded as merely evidence of sloppy mixing practices, or poor-quality raw materials, the new study suggests that these tiny lime clasts gave the concrete a previously unrecognized self-healing capability. [...] Upon further characterization of these lime clasts, using high-resolution multiscale imaging and chemical mapping techniques [...], the researchers gained new insights into the potential functionality of these lime clasts. Historically, it had been assumed that when lime was incorporated into Roman concrete, it was first combined with water to form a highly reactive paste-like material, in a process known as slaking. But this process alone could not account for the presence of the lime clasts. [MIT professor of civil and environmental engineering, Adam Masic] wondered: "Was it possible that the Romans might have actually directly used lime in its more reactive form, known as quicklime?"

Studying samples of this ancient concrete, he and his team determined that the white inclusions were, indeed, made out of various forms of calcium carbonate. And spectroscopic examination provided clues that these had been formed at extreme temperatures, as would be expected from the exothermic reaction produced by using quicklime instead of, or in addition to, the slaked lime in the mixture. Hot mixing, the team has now concluded, was actually the key to the super-durable nature. "The benefits of hot mixing are twofold," Masic says. "First, when the overall concrete is heated to high temperatures, it allows chemistries that are not possible if you only used slaked lime, producing high-temperature-associated compounds that would not otherwise form. Second, this increased temperature significantly reduces curing and setting times since all the reactions are accelerated, allowing for much faster construction."

During the hot mixing process, the lime clasts develop a characteristically brittle nanoparticulate architecture, creating an easily fractured and reactive calcium source, which, as the team proposed, could provide a critical self-healing functionality. As soon as tiny cracks start to form within the concrete, they can preferentially travel through the high-surface-area lime clasts. This material can then react with water, creating a calcium-saturated solution, which can recrystallize as calcium carbonate and quickly fill the crack, or react with pozzolanic materials to further strengthen the composite material. These reactions take place spontaneously and therefore automatically heal the cracks before they spread. Previous support for this hypothesis was found through the examination of other Roman concrete samples that exhibited calcite-filled cracks. According to MIT, the team is working to commercialize their modified cement material.

The findings have been published in the journal Science Advances.

The Food and Drug Administration on Friday approved a new Alzheimer's drug that may modestly slow the pace of cognitive decline early in the disease, but also carries risks of swelling and bleeding in the brain. From a report: The approval of the drug, lecanemab, to be marketed as Leqembi, is likely to generate considerable interest from patients and physicians. Studies of the drug -- an intravenous infusion administered every two weeks -- suggest it is more promising than the scant number of other treatments available. Still, several Alzheimer's experts said it was unclear from the medical evidence whether Leqembi could slow cognitive decline enough to be noticeable to patients.

Even a recent report of findings from a large 18-month clinical trial, published in the New England Journal of Medicine and co-written by scientists from the lead company making the drug, concluded that "longer trials are warranted to determine the efficacy and safety of lecanemab in early Alzheimer's disease." Eisai, a Japanese pharmaceutical company, led the development and testing of the drug. It is partnering with the American company Biogen, maker of the controversial Alzheimer's drug Aduhelm, for its commercialization and marketing, and the companies will split the profits equally. Eisai said the list price for Leqembi (pronounced le-KEM-bee) would be $26,500 per year. The price is slightly lower than Aduhelm's, but higher than that recommended by some analysts.

SonicSpike shares a report from Space.com: A giant cloud of magnetized plasma exploded from a sunspot hidden on the far side of the sun that might turn to face Earth only two days from now, so get ready for some solar fireworks. The explosion that erupted from behind the sun's eastern edge in the early morning of Tuesday (Jan. 3) was a so-called coronal mass ejection (CME), a burst of particles from the sun's upper atmosphere, or corona. The CME was accompanied by a powerful solar flare that lasted an overwhelming six hours, solar scientist Keith Strong said on Twitter. Neither the flare nor the CME were directed at Earth, but experts warn that the hidden sunspot that produced them will soon be facing the planet as the sun rotates.

Yesterday's flare and CME were detected by multiple sun-observing spacecraft including the joint NASA/European Space Agency Solar and Heliospheric Observatory mission (SOHO) and NASA's Solar Dynamics Observatory. The measurements helped scientists to determine that the sunspot, or active region, that produced the bursts, will move to the Earth-facing portion of the sun's disk within two days, according to Space Weather. [...] The British space weather forecaster Met Office predicts low solar activity in the next couple of days with a potential increase expected toward the end of this week as the mysterious sunspot emerges at the sun's eastern edge.

South Korea's Korea Pathfinder Lunar Orbiter spacecraft, known as Danuri, has sent back some high-resolution images from the moon. The Korea Aerospace Research Institute shared the views on Twitter this week. CNET reports: The first two come from late December and show the cratered landscape of the moon with Earth peeking above the horizon. The images are reminiscent of Earthrise views seen from NASA's Apollo and Artemis missions. KARI shared a second set of Earth images snapped during the new year.

An anonymous reader quotes a report from Motherboard: Scientists at Brookhaven National Laboratory have uncovered an entirely new kind of quantum entanglement, a phenomenon that causes particles to become weirdly linked, even across vast cosmic distances, reports a new study. The discovery allowed them to capture an unprecedented glimpse of the bizarre world inside atoms, the tiny building blocks of matter. The mind-bending research resolves a longstanding mystery about the nuclei of atoms, which contain particles called protons and neutrons, and could help shed light on topics ranging from quantum computing to astrophysics. The exciting discoveries took place at the Relativistic Heavy Ion Collider (RHIC), a specialized facility at Brookhaven in New York that can accelerate charged atoms, known as ions, to almost light speed. When these ions collide -- or even just pass near each other -- their interactions expose the inner workings of atoms, which are governed by the trippy laws of quantum mechanics. [...]

Now, for the first time ever, scientists at Brookhaven have captured interference patterns that are created by the entanglement of two particles with different charges, a breakthrough that has opened up a completely new window into the mysterious innards of atoms that make up visible matter in the universe, according to a study published on Wednesday in Science Advances. "There's never been any measurement in the past of interference between distinguishable particles," said Daniel Brandenburg, a physics professor at the Ohio State University who co-authored the new study, in a call with Motherboard. "That's the discovery; the application is that we get to use it to do some nuclear physics." Brandenburg and his colleagues achieved this milestone with the help of a sensitive detector called the Solenoidal Tracker at RHIC, or STAR, that captured interactions between gold ions that were boosted to the brink of light speed. Clouds of photons, which are particles that carry light, surround the ions and interact with another type of particle, called gluons, that hold atomic nuclei together. These encounters between the photons and the gluons set off a chain of events that ultimately created two new particles, called pions, which have opposite charges -- one positive and one negative. When these pions careened into the STAR detector, the precision instrument measured some of their key properties, such as velocity and angle of impact, which were then used to probe the size, shape, and arrangement of gluons inside the atomic nuclei with a precision that has never been achieved before.

Scientists have imaged atomic nuclei at lower energies before, but attempts to probe these structures at high energies has always produced a puzzling result. Nuclei in these experiments look way bigger than they should, according to models, an outcome that has puzzled scientists for decades. Now, the STAR collaboration has now solved this mystery by pinpointing a blurring effect that is linked to the photons in the experiment. Essentially, past studies captured one-dimensional glimpses of nuclei that did not account for important patterns in photons, such as their polarization direction. The new study included this polarization information, allowing Brandenburg and his colleagues to probe the nuclei from two angles, parallel and perpendicular to the photon's motion, producing a two-dimensional view that matches theoretical predictions. What's more, the team is even able to make out the rough positions of key particles in the nucleus, such as protons and neutrons, as well as the distribution of gluons. It also offers a new way to unravel persistent mysteries about the behavior of atoms at high energies. [...] Brandenburg hopes to repeat this technique, and versions of it, at RHIC and other facilities like the Large Hadron Collider, in order to tease out the long-hidden details inside atomic nuclei.

An anonymous reader quotes a report from The Register: Askern Medical Practice, a general practitioner surgery based in Doncaster, UK, managed to muddle its Christmas holiday message to patients by texting them they'd been diagnosed with "aggressive lung cancer with metastases." The message went out to patients of the medical facility -- there are reportedly about 8,000 of them -- on December 23, 2022. It asked patients to fill out a DS1500 form, which is used to help terminal patients expedite access to benefits because they may not have time for the usual bureaucratic delay.

About an hour after thoroughly alarming recipients of the not-so-glad tidings, the medical facility reportedly apologized in a follow-up text message. "Please accept our sincere apologies for the previous text message sent," the message reads, as reported by the BBC. "This has been sent in error. Our message to you should have read, 'We wish you a very merry Christmas and a Happy New Year.' In case of emergency please contact NHS 111." On Tuesday, the surgery took its apology public via its Facebook page. The surgery characterized the errant text message as both an administrative error and a computer-related error, without clarifying just how the mistake occurred. "While no data was breached, we can confirm an admin staff error was made, for which we apologized immediately upon becoming aware," Askern Medical Practice said in its post. "We would like to once again apologize sincerely to all patients for the distress caused. We take patient communication, confidentiality and data protection very seriously."

"We also pride in looking after our patients," the medical facility's apology continued. "We would like to reassure all our patients that the text message was a mistake (it was an internal patient supportive task amongst admin staff to act upon) and not related to you as a patient in any way. This was an isolated computer-related error for which we are extremely regretful, and steps are being taken to prevent a reoccurrence."

U.K. Prime Minister Rishi Sunak will on Wednesday announce plans to force school pupils in England to study math up to the age of 18, according to a Downing Street briefing. The initiative attempts to tackle innumeracy and better equip young people for the workplace. CNBC reports: In his first speech of 2023, Sunak is expected to outline plans for math to be offered through alternative qualification routes. Comparatively, traditional A-Levels subject-based qualifications allow high school students in England to elect academic subjects to study between the ages of 16 and 18. [...] Sunak's education proposals would only affect pupils in England. Education is a devolved issue, with Welsh, Scottish and Northern Irish authorities managing their own systems.

School-based education in England is only compulsory up to the age of 16, after which children can choose to pursue further academic qualifications such as A-Levels or alternative qualifications, or vocational training. The prime minister is expected to say in his Wednesday speech that the issue of mandatory math is "personal" for him. "Every opportunity I've had in life began with the education I was so fortunate to receive. And it's the single most important reason why I came into politics: to give every child the highest possible standard of education," he will say.

Sunak attended prestigious fee-paying institutions -- the Stroud School and Winchester College -- before studying at Oxford University. He is expected to acknowledge that the planned overhaul will be challenging and time consuming, with work beginning during the current parliamentary term and finishing in the next.

Better management of nitrogen-rich fertilisers through alternating crops, optimising use and other measures can yield huge environmental and health benefits, but must boost food production at the same time, researchers warned Wednesday. From a report: Reducing nitrogen pollution from global croplands is a "grand challenge," the group of international researchers said in a study in Nature outlining a dozen urgently-needed reforms. The intensive use of chemical fertilisers helped fuel the four-fold expansion of the human population over the last century, and will be crucial for feeding 10 billion people by 2050.

But the bumper crops of what was once called the Green Revolution have come at a terrible cost. Today, more than half the nitrogen in fertilisers seeps into the air and water, leading to deadly pollution, soil acidification, climate change, ozone depletion and biodiversity loss. "Given the multiple health, climate and environmental impacts of reactive nitrogen, it has to be reduced in all the mediums such as air and water," lead author Baojing Gu, a professor at Zhejiang University, told AFP. The benefits of doing so far outstrip the costs, he added.

The world is naturally awash in nitrogen, which is critical for the survival of all life on Earth, especially plants. Nearly 80 percent of Earth's atmosphere is nitrogen, albeit in a gaseous form (N2) of little direct use to most organisms. It is made available to plants when microbes that live within plants or soils turn it into ammonia through biological nitrogen fixation. This process funnels some 200 million tonnes of nitrogen into the soil and oceans every year.

Walt Cunningham, one of the early Apollo astronauts, died Tuesday after complications from a fall. He was 90. NPR reports: Walt Cunningham flew in space just one time. His flight in 1968 was an important -- and often forgotten one -- for the lunar program. Cunningham was the lunar module pilot of the first manned Apollo mission that went to space. Apollo 7's 11-day trip around the Earth was a key stepping stone to NASA's march to the moon. "The real accomplishment, of course, was the first manned landing on the moon," Cunningham told NPR in 2016. "But that was the fifth of what I've always described as five giant steps. The first one was the Apollo 7 mission, of course. Complete test of the Apollo spacecraft."

The launch came after a difficult time for NASA. Just 21 months before, a fire on the launchpad killed three astronauts during a test of Apollo 1. In the interim, NASA changed many procedures and the command module underwent a series of safety improvements. Cunningham said in 2016 that if Apollo 7 had not gone well, the U.S. wouldn't have landed on the moon before the end of the 1960s. "Historically, what the public doesn't realize," he said, "It is still the longest, most ambitious, most successful first test flight of any new flying machine ever."

"There were so many things that had to be tested," he recalled. During the flight, the crew test-fired the engine that would place Apollo into and out of lunar orbit, simulated docking maneuvers and did the first-ever live television broadcast from an American spacecraft. "It was hard to imagine that we could get through all those things [in an 11-day mission] without something going wrong and saying, 'hey you need to gotta come home," Cunningham said. The mission was deemed a success but it was the last time these astronauts would fly in space. There was tension between Apollo 7's commander, Wally Schirra, and mission control. As the flight dragged on, Schirra caught a cold and so did astronaut Donn Eisele and the crew's squabbles worsened with ground controllers. Despite that, Cunningham said, "As I look back on it, it was a job, a challenge, and a task that in the end was very well done."

An anonymous reader quotes a report from Ars Technica: Immune therapies have rewritten the game when it comes to cancer treatment, earning the "fifth pillar" label next to more tried and true treatments like radiation therapy, surgery, and chemotherapy. And no immunotherapy has garnered quite the same excitement as CAR T-cell therapy, first approved in 2017 by the Food and Drug Administration to treat a form of acute lymphoblastic leukemia. At the time, then-FDA Commissioner Scott Gottlieb called the approval "a new frontier in medical innovation," and it seemed like the possibilities for CAR T were near-endless. Flash-forward almost six years, and six therapies have been approved for blood cancers, including lymphomas, leukemia, and multiple myeloma. There's no question that when CAR T works, it works incredibly well. But why it doesn't work for the majority of patients or cancer types has befuddled researchers.

CAR T therapies also haven't yet been expanded to treat solid tumors, which make up the majority of cancers. The immune therapy hasn't been able to crack physical barriers, idiosyncratic tumor cells, and a suppressive microenvironment that characterize these cancers. But a new generation of CAR T therapies are emerging, equipped with highly effective small molecules that scientists hope will solve their low success rate for both blood cancers and solid tumors. Known as "armored CAR T," these infusions have been boosted with additional layers of protection and cancer-fighting proteins. Early research shows that the armored flavor of CAR T might have what it takes for immunotherapy to go the extra mile.

Briefly, immunotherapy can boost or restore the body's immune system by lowering cancer cells' defenses, priming the immune system's T cells to destroy tumors, or -- in the case of CAR T-cell therapy -- genetically editing a patient's T cells. Scientists do this by isolating a patient's T cells from their blood and inserting a gene for a chimeric antigen receptor -- a type of synthetic protein that has been specially made to bind to another protein present on the surface of that patient's cancer cells. Then, upon infusing these modified T cells back into a patient, the immune fighters will recognize and destroy the tumor cells when the patient's normal T cells have failed. That, at least, is the idea. But when CAR T doesn't work, a few factors could be at play. One, Lim said, is the tumor microenvironment, the set of chemicals and structures present in solid cancers that naturally suppress pushback from the body's immune system. Tumor heterogeneity is also a factor -- depending on the type and stage of cancer, tumor cells may not express the protein that the CAR T cells' receptors have been designed to recognize, blocking the ability of the CAR T cells to attack the cancer Finally, there are physical barriers on the outside of a solid tumor that can even prevent the T cells from entering inside to destroy the cancer. Armored CAR T is meant to overcome these difficulties. With this form of therapy, not only are T cells engineered to express a tumor cell's surface protein, they are also given potent cargo often in the form of small proteins called cytokines. If deployed on their own, such molecules can be toxic -- but pairing them with T cells designed to release them at the tumor site and nowhere else represents a promising new strategy. Jakub Svodoba, an oncologist at the University of Pennsylvania, "is helping to lead a clinical trial using armored CAR T-cell therapy to treat patients with non-Hodgkin lymphoma for whom previous CAR T therapy has failed," reports the Daily Beast. "Last month, he presented findings that the first seven patients treated with this therapy all responded to it and were alive eight months after receiving it. Svoboda said an important additional finding was that toxicities experienced by the patients -- a concern with cytokines -- were comparable to those from traditional CAR T therapy."

Wendell Lim, a cellular and molecular pharmacology researcher at the University of California, San Francisco, and his team are also working on an armored CAR-T therapy, with the potential for it to be used to treat solid tumors. "In a paper published in Science on Dec. 16, he and his colleagues designed T cells to release a cytokine directly to the tumors of mice with pancreatic cancer and melanoma," reports the Daily Beast. "In the study, they wrote that these cancers are 'nearly completely resistant' to treatment with traditional CAR T, but releasing a cytokine allowed the engineered T cells to get past the tumor microenvironment -- effectively solving one of the issues that has set the therapy back."

Weather records have been falling across Europe at a disconcerting rate in the last few days, say meteorologists. From a report: The warmest January day ever was recorded in at least eight European countries including Poland, Denmark, the Czech Republic, the Netherlands, Belarus, Lithuania and Latvia, according to data collated by Maximiliano Herrera, a climatologist who tracks extreme temperatures. In Korbielow, Poland, the mercury hit 19C (66F) -- a temperature the Silesian village is more used to in May, and 18C above the 1C annual average for January. In Javornik in the Czech Republic it was 19.6C, compared with an average of 3C for this time of year.

Temperatures in Vysokaje, Belarus, would normally hover around zero at this time of year. On Sunday they reached 16.4C, beating the country's previous record January high by 4.5C. Elsewhere on the continent, local records were broken at thousands of individual measuring stations, with nearly 950 toppled in Germany alone from 31 December to 2 January, Herrera said. Northern Spain and the south of France basked in beach weather, with 24.9C in Bilbao, its hottest ever January day, and records broken at stations in Cantabria, Asturias and the Basque region. Only Norway, Britain, Ireland, Italy and the south-east Mediterranean posted no records.

Dozens of once crystal-clear streams and rivers in Arctic Alaska are now running bright orange and cloudy, and in some cases they are becoming more acidic. From a report: This otherwise undeveloped landscape now looks as if an industrial mine has been in operation for decades, and scientists want to know why. Roman Dial, a professor of biology and mathematics at Alaska Pacific University, first noticed the stark water-quality changes while doing field work in the Brooks Range in 2020. He spent a month with a team of six graduate students, and they could not find adequate drinking water. "There's so many streams that are not just stained, they're so acidic that they curdle your powdered milk," he said. In others, the water was clear, "but you couldn't drink it because it had a really weird mineral taste and tang."

Dial, who has spent the last 40 years exploring the Arctic, was gathering data on climate-change-driven changes in Alaska's tree line for a project that also includes work from ecologists Patrick Sullivan, director of the Environment and Natural Resources Institute at the University of Alaska Anchorage, and Becky Hewitt, an environmental studies professor at Amherst College. Now the team is digging into the water-quality mystery. "I feel like I'm a grad student all over again in a lab that I don't know anything about, and I'm fascinated by it," Dial said. Most of the rusting waterways are located within some of Alaska's most remote protected lands: the Arctic National Wildlife Refuge, the Gates of the Arctic National Park and Preserve, the Kobuk Valley National Park, and the Selawik Wildlife Refuge. The phenomenon is visually striking.

"It seems like something's been broken open or something's been exposed in a way that has never been exposed before," Dial said. "All the hardrock geologists who look at these pictures, they're like, 'Oh, that looks like acid mine waste.'" But it's not mine waste. According to the researchers, the rusty coating on rocks and streambanks is coming from the land itself. The prevailing hypothesis is that climate warming is causing underlying permafrost to degrade. That releases sediments rich in iron, and when those sediments hit running water and open air, they oxidize and turn a deep rusty orange color. The oxidation of minerals in the soil may also be making the water more acidic. The research team is still early in the process of identifying the cause in order to better explain the consequences. "I think the pH issue" -- the acidity of the water -- "is truly alarming," said Hewitt.

The new year has just begun, but the cosmos are already set to make history in 2023. From a report: A comet discovered less than a year ago has traveled billions of miles from its believed origins at the edge of our solar system and will be visible in just a few weeks during what will likely be its only recorded appearance. The comet, C/2022 E3 (ZTF), was first seen in March 2022 as it made its way through Jupiter's orbit. According to NASA, it's a long-period comet believed to come from the Oort Cloud, the most distant region of Earth's solar system that's "like a big, thick-walled bubble made of icy pieces of space debris" that can get even bigger than mountains. The inner edge of this region is thought to be between 2,000 and 5,000 astronomical units (AUs) from the sun -- between 186 billion and 465 billion miles.

This means that C/2022 E3 (ZTF) has made a rare, once-in-a-lifetime journey to be close to Earth. "Most known long-period comets have been seen only once in recorded history because their orbital periods are so, well, long," NASA says. "Countless more unknown long-period comets have never been seen by human eyes. Some have orbits so long that the last time they passed through the inner solar system, our species did not yet exist."

Now, the recently discovered E3 comet, which has been seen with a bright greenish coma and "short broad" dust tail, is set to make its closest approach to the sun on January 12. It will make its closest approach to Earth on February 2. Astrophotographer Dan Bartlett managed to capture an image of the comet in December from his backyard in California. He was able to see "intricate tail structure" in the comet's plasma tail, he said, and "conditions are improving."

Long-time geriatrician James Kirkland is a Mayo clinic researcher joining "a growing movement to halt chronic disease by protecting brains and bodies from the biological fallout of aging," reports Ars Technica.

"While researchers like Kirkland don't expect to extend lifespan, they hope to lengthen 'health span,' the time that a person lives free of disease." One of their targets is decrepit cells that build up in tissues as people age. These "senescent" cells have reached a point — due to damage, stress or just time — when they stop dividing, but don't die. While senescent cells typically make up only a small fraction of the overall cell population, they accounted for up to 36 percent of cells in some organs in aging mice, one study showed. And they don't just sit there quietly. Senescent cells can release a slew of compounds that create a toxic, inflamed environment that primes tissues for chronic illness. Senescent cells have been linked to diabetes, stroke, osteoporosis and several other conditions of aging.

These noxious cells, along with the idea that getting rid of them could mitigate chronic illnesses and the discomforts of aging, are getting serious attention. The U.S. National Institutes of Health is investing $125 million in a new research effort, called SenNet, that aims to identify and map senescent cells in the human body as well as in mice over the natural lifespan. And the National Institute on Aging has put up more than $3 million over four years for the Translational Geroscience Network multicenter team led by Kirkland that is running preliminary clinical trials of potential antiaging treatments. Drugs that kill senescent cells — called senolytics — are among the top candidates. Small-scale trials of these are already underway in people with conditions including Alzheimer's, osteoarthritis and kidney disease.

"It's an emerging and incredibly exciting, and maybe even game-changing, area," says John Varga, chief of rheumatology at the University of Michigan Medical School in Ann Arbor, who isn't part of the Translational Geroscience Network. But he and others sound a note of caution as well, and some scientists think the field's potential has been overblown. "There's a lot of hype," says Varga. "I do have, I would say, a very healthy skepticism." He warns his patients of the many unknowns and tells them that trying senolytic supplementation on their own could be dangerous....

So far, evidence that destroying senescent cells helps to improve health span mostly comes from laboratory mice. Only a couple of preliminary human trials have been completed, with hints of promise but far from blockbuster results.
In conjunction with SpaceX and Axiom Space, Kirkland and a colleague also are investigating how space radiation affects senescence indicators in astronauts, the article points out . "They hypothesize that participants in future long-term missions to Mars might have to monitor their bodies for senescence or pack senolytics to stave off accelerated cellular aging caused by extended exposure to radiation."

CNN reports: Mars may seem like a dry, desolate place, but the red planet transforms into an otherworldly wonderland in winter, according to a new video shared by NASA....

"Enough snow falls that you could snowshoe across it," said Sylvain Piqueux, a Mars scientist at NASA's Jet Propulsion Laboratory in Pasadena, California, in a statement from a NASA release. "If you were looking for skiing, though, you'd have to go into a crater or cliffside, where snow could build up on a sloped surface."

So far, no orbiters or rovers have been able to see snow fall on the red planet because the weather phenomenon only occurs at the poles beneath cloud cover at night. The cameras on the orbiters can't peer through the clouds, and no robotic explorers have been developed that could survive the freezing temperatures at the poles. [ -190 degrees Fahrenheit, or -123 degrees Celsius) ] However, the Mars Climate Sounder instrument on the Mars Reconnaissance Orbiter can detect light that's invisible to the human eye. It has made detections of carbon dioxide snow falling at the Martian poles. The Phoenix lander, which arrived on Mars in 2008, also used one of its laser instruments to detect water-ice snow from its spot about 1,000 miles (1,609 kilometers) away from the Martian north pole....

"Because carbon dioxide ice has a symmetry of four, we know dry-ice snowflakes would be cube-shaped," Piqueux said. "Thanks to the Mars Climate Sounder, we can tell these snowflakes would be smaller than the width of a human hair."

Ice and carbon dioxide-based frosts also form on Mars, and they can occur farther away from the poles. The Odyssey orbiter (which entered Mars' orbit in 2001) has watched frost forming and turning to a gas in the sunlight, while the Viking landers spotted icy frost on Mars when they arrived in the 1970s. At the end of winter, the season's buildup of ice can thaw and turn into gas, creating unique shapes that have reminded NASA scientists of Swiss cheese, Dalmatian spots, fried eggs, spiders and other unusual formations.
That's just the beginning, according to a press release from NASA's Jet Propulsion Lab: This "thawing" also causes geysers to erupt: Translucent ice allows sunlight to heat up gas underneath it, and that gas eventually bursts out, sending fans of dust onto the surface. Scientists have actually begun to study these fans as a way to learn more about which way Martian winds are blowing.
And they also note that the camera aboard NASA's Mars Reconnaissance Orbiter also captured some surprisingly colorful images of sand dunes covered by frost

To hear the first results from the James Webb Telescope, 200 astronomers descended on the Space Telescope Science Institute for three days in December, reports the New York Times, with an update on what may be 2022's biggest science story. The $10 billion telescope "is working even better than astronomers had dared to hope" -- and astronomers are ecstatic: At a reception after the first day of the meeting, John Mather of NASA's Goddard Space Flight Center and Webb's senior project scientist from the start, raised a glass to the 20,000 people who built the telescope, the 600 astronomers who had tested it in space and the new generation of scientists who would use it. "Some of you weren't even born when we started planning for it," he said. "Have at it!"
Launched on Christmas one year ago, the Webb telescope "is seven times as powerful as its predecessor, the Hubble Space Telescope," the Times reports -- sharing what was revealed in that auditorium in December: One by one, astronomers marched to the podium and, speaking rapidly to obey the 12-minute limit, blitzed through a cosmos of discoveries. Galaxies that, even in their relative youth, had already spawned supermassive black holes. Atmospheric studies of some of the seven rocky exoplanets orbiting Trappist 1, a red dwarf star that might harbor habitable planets. (Data suggest that at least two of the exoplanets lack the bulky primordial hydrogen atmospheres that would choke off life as we know it, but they may have skimpy atmospheres of denser molecules like water or carbon dioxide.) "We're in business," declared Bjorn Benneke of the University of Montreal, as he presented data of one of the exoplanets.

Megan Reiter of Rice University took her colleagues on a "deep dive" through the Cosmic Cliffs, a cloudy hotbed of star formation in the Carina constellation, which was a favorite early piece of sky candy. She is tracing how jets from new stars, shock waves and ionizing radiation from more massive nearby stars that were born boiling hot are constantly reshaping the cosmic geography and triggering the formation of new stars. "This could be a template for what our own sun went through when it was formed," Dr. Reiter said in an interview.

Between presentations, on the sidelines and in the hallways, senior astronomers who were on hand in 1989 when the idea of the Webb telescope was first broached congratulated one another and traded war stories about the telescope's development. They gasped audibly as the youngsters showed off data that blew past their own achievements with the Hubble.
The telescope is a joint project of NASA, the European Space Agency and the Canadian Space Agency. And appropriately for New Year's Eve, the article concludes with a look to the future: Thus far the telescope, bristling with cameras, spectroscopes and other instruments, is exceeding expectations. (Its resolving power is twice as good as advertised.) The telescope's flawless launch, Dr. Rigby reported, has left it with enough maneuvering fuel to keep it working for 26 years or more. "These are happy numbers...."

The closing talk fell to Dr. Mather. He limned the telescope's history, and gave a shout-out to Barbara Mikulski, the former senator of Maryland, who supported the project in 2011 when it was in danger of being canceled. He also previewed NASA's next big act: a 12-meter space telescope called the Habitable Worlds Observatory that would seek out planets and study them.

If humankind detects a message from an advanced civilisation, "It would be a transformative event for humankind," writes the Guardian, "one the world's nations are surely prepared for.

"Or are they?" "Look at the mess we made when Covid hit. We'd be like headless chickens," says Dr John Elliott, a computational linguist at the University of St Andrews. "We cannot afford to be ill-prepared, scientifically, socially, and politically rudderless, for an event that could happen at any time and which we cannot afford to mismanage."

This frank assessment of Earth's unreadiness for contact with life elsewhere underpins the creation of the Seti (Search for Extraterrestrial Intelligence) post-detection hub at St Andrews. Over the next month or two, Elliott aims to bring together a core team of international researchers and affiliates. They will take on the job of getting ready: to analyse mysterious signals, or even artefacts, and work out every aspect of how we should respond.... "After the initial announcement, we'd be looking at societal impact, information dissemination, the media, the impact on religions and belief systems, the potential for disinformation, what analytical capabilities we'll need, and much more: having strategies in place, being transparent with everything we've discovered — what we know and what we do not know," says Elliott....

Lewis Dartnell, an astrobiologist and professor of science communication at the University of Westminster, said the new hub at St Andrews is "an important step in raising awareness at how ill-prepared we currently are" for detecting a signal from an alien civilisation. But he added that any intelligent aliens were likely to be hundreds if not thousands of light years away, meaning communication time would be on the scale of many centuries. "Even if we were to receive a signal tomorrow, we would have plenty of breathing space to assemble an international team of diverse experts to attempt to decipher the meaning of the message, and carefully consider how the Earth should respond, and even if we should.

"The bigger concern is to establish some form of international agreement to prevent capable individuals or private corporations from responding independently — before a consensus has formed on whether it is safe to respond at all, and what we would want to say as one planet," he said.