Researchers are developing techniques to genetically modify cancer-fighting immune cells directly inside patients rather than in expensive laboratory facilities, potentially making CAR-T therapy accessible to far more people.

Current CAR-T treatments require removing a patient's T cells, shipping them to specialized facilities for genetic engineering, then returning them weeks later at costs around $500,000 per dose. The new "in vivo" approaches use viral vectors or RNA-loaded nanoparticles to deliver genetic instructions directly to T cells circulating in the bloodstream, which could reduce costs by an order of magnitude. Companies including Capstan Therapeutics, co-founded by Nobel laureates, and AstraZeneca-backed EsoBiotec have launched early human trials. While only about 200 US centers currently offer traditional CAR-T therapy, the approach could make the powerful treatment available on demand like conventional drugs.

Abstract of a paper on NBER: We elicited over a million stated preference choices over 126 dimensions or "aspects" of well-being from a sample of 3,358 respondents on Amazon's Mechanical Turk (MTurk). Our surveys also collected self-reported well-being (SWB) questions about respondents' current levels of the aspects of well-being. From the stated preference data, we estimate relative log marginal utilities per point on our 0-100 response scale for each aspect. We validate these estimates by comparing them to alternative methods for estimating preferences. Our findings provide empirical evidence that both complements and challenges philosophical perspectives on human desires and values. Our results support Aristotelian notions of eudaimonia through family relationships and Maslow's emphasis on basic security needs, yet also suggest that contemporary theories of well-being may overemphasize abstract concepts such as happiness and life satisfaction, while undervaluing concrete aspects such as family well-being, financial security, and health, that respondents place the highest marginal utilities on. We document substantial heterogeneity in preferences across respondents within (but not between) demographic groups, with current SWB levels explaining a significant portion of the variation.

Around the world fungal infections kill an estimated 2.5 million people a year, notes a report from CNN. But new research predicts that certain species of infection-causing Aspergillus fungi could spread into new areas as the earth's temperature rises. ("The study, published this month, is currently being peer reviewed...") Aspergillus fungi grow like small filaments in soils all over the world. Like almost all fungi, they release huge numbers of tiny spores that spread through the air. Humans inhale spores every day but most people won't experience any health issues; their immune system clears them. It's a different story for those with lung conditions including asthma, cystic fibrosis and COPD, as well as people with compromised immune systems, such as cancer and organ transplant patients, and those who have had severe flu or Covid-19. If the body's immune system fails to clear the spores, the fungus "starts to grow and basically kind of eat you from the inside out, saying it really bluntly," said Norman van Rijn, one of the study's authors and a climate change and infectious diseases researcher at the University of Manchester. Aspergillosis has very high mortality rates at around 20% to 40%, he said. It's also very difficult to diagnose, as doctors don't always have it on their radar and patients often present with fevers and coughs, symptoms common to many illnesses. Fungal pathogens are also becoming increasingly resistant to treatment, van Rijn added. There are only four classes of antifungal medicines available...

Aspergillus flavus, a species that tends to prefer hotter, tropical climates, could increase its spread by 16% if humans continue burning large amounts of fossil fuels, the study found... [Mainly in parts of Europe and the northernmost edges of Scandinavia, Russia, China, and Canada, and the western edge of Alaska.] This species can cause severe infections in humans and is resistant to many antifungal medications. It also infects a range of food crops, posing a potential threat to food security. The World Health Organization added Aspergillus flavus to its critical group of fungal pathogens in 2022 because of its public health impact and antifungal resistance risk...

Conversely, temperatures in some regions, including sub-Saharan Africa, could become so hot they are no longer hospitable to Aspergillus fungi. This could bring its own problems, as fungi play an important role in ecosystems, including healthy soils. As well as expanding their growing range, a warming world could also be increasing fungi's temperature tolerance, allowing them to better survive inside human bodies. Extreme weather events such as drought, floods and heatwaves can affect fungi, too, helping to spread spores over long distances.
Thanks to Slashdot reader quonset for sharing the article.

Science magazine reports that hummingbird feeders "have become a major evolutionary force," according to research published this week in Global Change Biology. (At least for the Anna's hummingbird, a common species in the western U.S. Over just a few generations, their beaks have dramatically changed in size and shape.... [A]s feeders proliferated, Anna's hummingbird beaks got longer and larger, which may reflect an adaptation to slurp up far more nectar than flowers can naturally provide. Developing a bigger beak to access feeders "is like having a large spoon to eat with," says senior author Alejandro Rico-Guevara, an evolutionary biologist at the University of Washington. This change was more pronounced in areas where feeders were dense. But in birds that lived in colder regions north of the species' historical range, the researchers spotted the opposite trend: Their beaks became shorter and smaller. This finding also makes sense: The researchers used an infrared camera to show for the first time that hummingbirds use their beaks to thermoregulate, by dissipating heat while they are perched. A smaller beak has less surface area — and would therefore help conserve heat...

The most surprising finding, though, was how quickly these changes took place. By the 1950s, hummingbirds were noticeably different from those of the 1930s: a time span of only about 10 generations of birds, Alexandre says.
Carleton University animal behaviorist Roslyn Dakin (who wasn't involved with the study) says the new paper beautifully shows "evolution in action" — and adds nuance to our conception of humans as an evolutionary force. "I think we're going to find more and more examples of contemporary and subtle changes, that we're shaping, indirectly, in many more species."

Thanks to long-time Slashdot reader sciencehabit for sharing the article.

"What if ultrafast pulses of light could operate computers at speeds a million times faster than today's best processors?" asks the University of Arizona.

"A team of scientists, including researchers from the University of Arizona, are working to make that possible." In a groundbreaking international effort, researchers from the Department of Physics in the College of Science and the James C. Wyant College of Optical Sciences demonstrated a way to manipulate electrons in graphene using pulses of light that last less than a trillionth of a second. By leveraging a quantum effect known as tunneling, they recorded electrons bypassing a physical barrier almost instantaneously, a feat that redefines the potential limits of computer processing power. A study published in Nature Communications highlights how the technique could lead to processing speeds in the petahertz range — over 1,000 times faster than modern computer chips. Sending data at those speeds would revolutionize computing as we know it, said Mohammed Hassan, an associate professor of physics and optical sciences. Hassan has long pursued light-based computer technology and previously led efforts to develop the world's fastest electron microscope...

[T]he researchers used a laser that switches off and on at a rate of 638 attoseconds to create what Hassan called "the world's fastest petahertz quantum transistor... For reference, a single attosecond is one-quintillionth of a second," Hassan said. "That means that this achievement represents a big leap forward in the development of ultrafast computer technologies by realizing a petahertz-speed transistor." While some scientific advancements occur under strict conditions, including temperature and pressure, this new transistor performed in ambient conditions — opening the way to commercialization and use in everyday electronics. Hassan is working with Tech Launch Arizona, the office that works with investigators to commercialize inventions stemming from U of A research in order to patent and market innovations.

While the original invention used a specialized laser, the researchers are furthering development of a transistor compatible with commercially available equipment. "I hope we can collaborate with industry partners to realize this petahertz-speed transistor on a microchip," Hassan said.
Thanks to long-time Slashdot reader goslackware for sharing the news.

Rice plants can inherit tolerance to cold without changes to their genomes, according to a decade-long study carried out by researchers in China. From a report: The work, published in Cell this week, strengthens the evidence for a form of evolution in which environmental pressures induce heritable changes that do not alter an organism's DNA. The study conducted experiments that demonstrate, for the first time, the mechanism for these changes -- 'epigenetic' tweaks to chemical markers on the plant's DNA that don't actually tinker with the sequences themselves.

"What they're showing is extremely convincing; I would say that it's a landmark in the field," says Leandro Quadrana, a plant geneticist at the French National Centre for Scientific Research in Paris-Saclay. Michael Skinner, who studies epigenetic inheritance at Washington State University in Pullman, says the study adds to the growing body of evidence challenging the prevailing view of evolution that the only way that adaptations emerge is through gradual natural selection of randomly arising DNA mutations. This study shows that the environment isn't just a passive actor in evolution, but a selective force inducing a targeted change.

Harvard University's Galileo Project is using AI to automate the search for unidentified anomalous phenomena, marking a significant shift in how academics approach what was once considered fringe research. The project operates a Massachusetts observatory equipped with infrared cameras, acoustic sensors, and radio-frequency analyzers that continuously scan the sky for unusual objects.

Researchers Laura Domine and Richard Cloete are training machine learning algorithms to recognize all normal aerial phenomena -- planes, birds, drones, weather balloons -- so the system can flag genuine anomalies for human analysis. The team uses computer vision software called YOLO (You Only Look Once) and has generated hundreds of thousands of synthetic images to train their models, though the software currently identifies only 36% of aircraft captured by infrared cameras.

The Pentagon is pursuing parallel efforts through its All-domain Anomaly Resolution Office, which has examined over 1,800 UAP reports and identified 50 to 60 cases as "true anomalies" that government scientists cannot explain. AARO has developed its own sensor suite called Gremlin, using similar technology to Harvard's observatory. Both programs represent the growing legitimization of UAP research following 2017 Defense Department disclosures about military encounters with unexplained aerial phenomena.

Cornell University researchers have solved a kitchen mystery by demonstrating that sharp knives produce fewer and slower-moving droplets when cutting onions compared to dull blades. The findings used high-speed cameras and particle tracking to analyze droplet formation during onion cutting at speeds up to 20,000 frames per second.

The team discovered that onion droplets form through a two-stage process: an initial violent ejection driven by internal pressure, followed by slower fragmentation of liquid streams in air. Blunter blades create up to 40 times more droplets because the onion's tough outer skin acts as a barrier, allowing the softer interior tissue to compress significantly before rupturing and releasing pressurized liquid.

The research reveals that droplets are ejected at speeds between 1 and 40 meters per second, with the fastest ones posing the greatest risk of reaching a cook's eyes. Beyond tear reduction, the study suggests sharp knives may also limit the spread of foodborne pathogens, since atomized droplets can carry bacteria like Salmonella from contaminated cutting boards.

Astronomers have confirmed the existence of a bizarre planet in the Nu Octantis binary star system that orbits in reverse between two stars -- one of which is now a white dwarf. This retrograde orbit, once thought impossible, defies traditional planetary formation models and may have resulted from dramatic shifts in the system's history. New Scientist reports: The key observation was that the Nu Octantis planet is retrograde -- the planet and one star both orbit the second star, but they do so in opposite directions, with the planet having the tighter orbit around the second star. [Man Hoi Lee at the University of Hong Kong] says this is unusual but makes the system's configuration stable -- even though it means that the planet repeatedly moves through the narrow space between the two stars. His team was able to determine this with lots of certainty thanks to improved measuring devices, such as the HARPS spectrograph at the European Southern Observatory's 3.6-metre telescope in Chile. The fact that the planet's signal persisted through years of observation helped too. "We are pretty sure [the planet] is real, because if it was something like stellar activity, it shouldn't be so consistent in years of data," says Lee.

But this backwards-moving planet isn't the only exotic feature of Nu Octantis. The researchers used the European Southern Observatory's Very Large Telescope, also in Chile, to determine that one of its stars is a white dwarf, which means that it has reached the end of its life cycle, becoming denser and smaller. Lee says this complicates the Nu Octantis threesome's history because mathematical models of its past show that the planet's current orbit was impossible when this star was younger, bigger and brighter. So, the planet either used to orbit both stars at once, but then radically shifted trajectory when one of the two stars became a white dwarf, or it was formed from the mass that the star ejected as it transformed into a white dwarf. Future observations, and a lot more mathematical modelling, may be able to pinpoint which of these scenarios is more likely to have occurred, but both are rather novel, says Lee. The research has been published in the journal Nature.

An anonymous reader quotes a report from Phys.Org: Neuroscientists and materials scientists have created contact lenses that enable infrared vision in both humans and mice by converting infrared light into visible light. Unlike infrared night vision goggles, the contact lenses, described in the journal Cell, do not require a power source -- and they enable the wearer to perceive multiple infrared wavelengths. Because they're transparent, users can see both infrared and visible light simultaneously, though infrared vision was enhanced when participants had their eyes closed. [...] The contact lens technology uses nanoparticles that absorb infrared light and convert it into wavelengths that are visible to mammalian eyes (e.g., electromagnetic radiation in the 400-700 nm range). The nanoparticles specifically enable the detection of "near-infrared light," which is infrared light in the 800-1600 nm range, just beyond what humans can already see.

The team previously showed that these nanoparticles enable infrared vision in mice when injected into the retina, but they wanted to design a less invasive option. To create the contact lenses, the team combined the nanoparticles with flexible, nontoxic polymers that are used in standard soft contact lenses. After showing that the contact lenses were nontoxic, they tested their function in both humans and mice. They found that contact lens-wearing mice displayed behaviors suggesting that they could see infrared wavelengths. For example, when the mice were given the choice of a dark box and an infrared-illuminated box, contact-wearing mice chose the dark box whereas contact-less mice showed no preference. The mice also showed physiological signals of infrared vision: the pupils of contact-wearing mice constricted in the presence of infrared light, and brain imaging revealed that infrared light caused their visual processing centers to light up. In humans, the infrared contact lenses enabled participants to accurately detect flashing morse code-like signals and to perceive the direction of incoming infrared light.

An additional tweak to the contact lenses allows users to differentiate between different spectra of infrared light by engineering the nanoparticles to color-code different infrared wavelengths. For example, infrared wavelengths of 980 nm were converted to blue light, wavelengths of 808 nm were converted to green light, and wavelengths of 1,532 nm were converted to red light. In addition to enabling wearers to perceive more detail within the infrared spectrum, these color-coding nanoparticles could be modified to help color-blind people see wavelengths that they would otherwise be unable to detect. [...] Because the contact lenses have limited ability to capture fine details (due to their close proximity to the retina, which causes the converted light particles to scatter), the team also developed a wearable glass system using the same nanoparticle technology, which enabled participants to perceive higher-resolution infrared information. Currently, the contact lenses are only able to detect infrared radiation projected from an LED light source, but the researchers are working to increase the nanoparticles' sensitivity so that they can detect lower levels of infrared light.

Wisk Aero and NASA have signed a new five-year partnership to advance the safe integration of autonomous, all-electric aircraft into U.S. airspace, focusing on urban air mobility and regulated eVTOL flight. Electrek reports: Wisk Aero shared details of its refreshed partnership with NASA this week. The autonomous aviation specialist has signed a new five-year Non-Reimbursable Space Act Agreement (NRSAA) with the renowned space administration. Per Wisk, this new agreement focuses on critical research led by NASA's Air Traffic Management Exploration (ATM-X) project, which is centered around the advancement of commercialized autonomous aircraft travel under Instrument Flight Rules (IFR) in the National Airspace System (NAS).

As a specialist in autonomous, zero-emission aircraft, Wisk intends to continue its research alongside NASA to help regulators determine future eVTOL flight procedures and capabilities in the US. Regulatory developments on the to-do list for the latest NRSAA include optimizing airspace and route designs for highly automated UAM operations, establishing critical aircraft and ground-based safety system requirements for autonomous flight in urban environments, and establishing Air Traffic Control (ATC) communication protocols and procedures for seamless integration of future UAM aircraft. To achieve these goals, Wisk said its research with NASA will more specifically focus on utilizing advanced simulation and Live Virtual Constructive (LVC) flight environments, which combine live flights with a simulated airspace to enable researchers to assess future operations.

The teams from Wisk and NASA already met last month, continuing their research while beginning to determine how instrument flight procedures and advanced technologies can work together to enable safe autonomous passenger flights by 2030. Wisk Aero is a wholly owned subsidiary of Boeing based in California. The aerospace manufacturer said last year that it expects its pilotless air-taxi to begin carrying passengers "later in the decade."

Scientists have discovered a previously unknown bacterium aboard China's Tiangong space station. "It has been named Niallia tiangongensis, and it inhabited the cockpit controls on the station, living in microgravity conditions," reports Wired. From the report: According to China Central Television, the country's national broadcaster, taikonauts (Chinese astronauts) collected swab samples from the space station in May 2023, which were then frozen and sent back to Earth for study. The aim of this work was to investigate the behavior of microorganisms, gathered from a completely sealed environment with a human crew, during space travel, as part of the China Space Station Habitation Area Microbiome Program (CHAMP). A paper published in the Journal of Systematic and Evolutionary Microbiology describes how analysis of samples from the space station revealed this previously unseen bacterial species, which belongs to the genus Niallia. Genomic sequencing showed that its closest terrestrial relative is the bacterium Niallia circulans, although the Tiangong species has substantial genetic differences. [...]

It is unclear whether the newly discovered microbe evolved on the space station or whether it is part of the vast sea of as yet unidentified microorganisms on Earth. To date, tens of thousands of bacterial species have been cataloged, although there are estimated to be billions more unclassified species on Earth. The discovery of Niallia tiangongensis will provide a better understanding of the microscopic hazards that the next generation of space travelers will face and help design sanitation protocols for extended missions. It is still too early to determine whether the space bacterium poses any danger to taikonauts aboard Tiangong, although it is known that its terrestrial relative, Niallia circulans, can cause sepsis, especially in immunocompromised people.

Starfish Space plans to perform the first commercial satellite docking in orbit with its Otter Pup 2 mission, aiming to connect to an unprepared D-Orbit ION spacecraft using an electrostatic capture mechanism and autonomous navigation software. NASASpaceFlight.com reports: This follows the company's first attempt, which saw the Otter Pup 1 mission unable to dock with its target due to a thruster failure. The Otter Pup 2 spacecraft will be deployed from a quarter plate on the upper stage adapter of the SpaceX Falcon 9 rocket, placing it into a sun synchronous orbit altitude of 510 km inclined 97.4 degrees. The target will be a D-Orbit ION spacecraft which will simulate a client payload, which is not equipped with a traditional docking adapter or capture plate as you might see aboard a space station or other rendezvous target. Instead, Starfish Space's Nautilus capture mechanism will feature a special end effector connected to the end of the capture mechanism. This end effector will enable Otter Pup 2 to dock with the ION through electrostatic adhesion.

"An electromagnet will be integrated into the end effector and will be used as a backup option to the electrostatic end effector, to dock with the ION through magnetic attraction," the company notes. The goal is to eventually commission its Otter satellite servicing vehicle to allow for servicing of previously launched satellites. The company's first Otter missions include customers such as NASA, the U.S. Space Force, and Intelsat, with the goal of flying those missions as soon as 2026. [...] Following the thruster issues on the first mission, this flight will feature two ThrustMe thrusters, which use an electric propulsion system based on gridded ion thruster technology.

A new study reveals that about 3.8 million years after the solar system's first solids formed, Jupiter was twice its current size with a magnetic field 50 times stronger, profoundly influencing the structure of the early solar system. Phys.Org reports: [Konstantin Batygin, professor of planetary science at Caltech] and [Fred C. Adams, professor of physics and astronomy at the University of Michigan] approached this question by studying Jupiter's tiny moons Amalthea and Thebe, which orbit even closer to Jupiter than Io, the smallest and nearest of the planet's four large Galilean moons. Because Amalthea and Thebe have slightly tilted orbits, Batygin and Adams analyzed these small orbital discrepancies to calculate Jupiter's original size: approximately twice its current radius, with a predicted volume that is the equivalent of over 2,000 Earths. The researchers also determined that Jupiter's magnetic field at that time was approximately 50 times stronger than it is today.

Adams highlights the remarkable imprint the past has left on today's solar system: "It's astonishing that even after 4.5 billion years, enough clues remain to let us reconstruct Jupiter's physical state at the dawn of its existence." Importantly, these insights were achieved through independent constraints that bypass traditional uncertainties in planetary formation models -- which often rely on assumptions about gas opacity, accretion rate, or the mass of the heavy element core. Instead, the team focused on the orbital dynamics of Jupiter's moons and the conservation of the planet's angular momentum -- quantities that are directly measurable.

Their analysis establishes a clear snapshot of Jupiter at the moment the surrounding solar nebula evaporated, a pivotal transition point when the building materials for planet formation disappeared and the primordial architecture of the solar system was locked in. The results add crucial details to existing planet formation theories, which suggest that Jupiter and other giant planets around other stars formed via core accretion, a process by which a rocky and icy core rapidly gathers gas. The findings have been published in the journal Nature Astronomy.

An anonymous reader quotes a report from Ars Technica: There's a lot of matter around, which ensures that any antimatter produced experiences a very short lifespan. Studying antimatter, therefore, has been extremely difficult. But that's changed a bit in recent years, as CERN has set up a facility that produces and traps antimatter, allowing for extensive studies of its properties, including entire anti-atoms. Unfortunately, the hardware used to capture antiprotons also produces interference that limits the precision with which measurements can be made. So CERN decided that it might be good to determine how to move the antimatter away from where it's produced. Since it was tackling that problem anyway, CERN decided to make a shipping container for antimatter, allowing it to be put on a truck and potentially taken to labs throughout Europe. [...]

Overall, the hardware stayed cold, generally at a bit over 5 Kelvin. The exception was when the system was reconnected to the antimatter source hardware and the system reconnected to the electrical system at CERN. While those actions show up as temperature spikes, the superconducting magnets remained well under 7 Kelvin. An accelerometer was in place to track the forces experienced by the hardware while the truck was moving. This showed that changes in the truck's speed produced turbulence in the liquid helium, making measurements of its presence unreliable. Levels had dropped from about 75 percent of maximum to 30 percent by the time the system was reconnected, suggesting that liquid helium presents the key limiting factor in shipping. Measurements made while the system was in transit suggest that the whole process occurred losslessly, meaning that not a single proton escaped during the entire transport. The findings have been published in the journal Nature.