×
Medicine

Amazon Pharmacy Automates Discounts To Help Insulin Patients Get Pledged Prices (reuters.com) 41

Amazon said on Tuesday its online pharmacy will automatically apply manufacturer-sponsored coupons to more than 15 insulin and diabetes medicines to help patients access discounts pledged by the drug industry. From a report: With the new program, patients using Amazon Pharmacy will no longer have to search for and manually enter coupons from the three largest insulin makers, Novo Nordisk, Eli Lilly, and Sanofi, to lower the cost of their insulin to as little as $35 for a month's supply, the company said.

Novo, Lilly and Sanofi announced in March that they would slash their insulin prices by at least 70% by or in 2024, but a report from Senator Elizabeth Warren released last month said some patients were finding it difficult to get already discounted generic insulin from pharmacies at the promised lower price. Despite Lilly lowering the list price of its Insulin Lispro to $25 per vial in May, patients were still being quoted as much as $330 for the medicine, were not being told about cheaper options when they went to pharmacies, and were finding it difficult to use Lilly's savings program, Warren's report found. Vin Gupta, Amazon Pharmacy's Chief Medical Officer, said the report highlighted the need to make it easier for patients to get their insulin at the lowest possible prices.

Space

Could Supermassive Black Holes Explain Our Universe's Gravitational-Wave 'Hum'? (space.com) 19

"Earlier this year, after 15 years of searching, scientists finally heard the background hum of low-frequency gravitational waves that fill our universe," writes Space.com.

"Now, the hard work of searching for the source of these ripples in spacetime can begin." Currently, the primary suspects in this case are pairings of supermassive black holes with masses millions, or even billions, of times that of the sun. However, that doesn't mean that there isn't room for a few unusual suspects, which could potentially point us toward new physics....

[G]ravitational waves detected by the Laser Interferometer Gravitational-Wave Observatory (LIGO) express wavelengths that are thousands of miles (or km) in length and hold frequencies of milliseconds to seconds. The new gravitational waves detected by the North American Nanohertz Observatory for Gravitational Waves (NANOGrav), by contrast, have wavelengths on a scale of trillions of miles (or km). This is similar to the distance between the sun and its neighboring star, Proxima Centauri, a staggering 20 light-years in length. Plus, NANOGrav gravitational wavelengths have frequencies on scales of years instead of mere seconds. Practically, what this means is scientists need to build over 15 years of NANOGrav data to confirm a low-frequency gravitational wave detection.

But, when it happens, it's worth the wait. That's because these results have the capacity to point us toward new information about our universe... "The detection of low-frequency gravitational waves means they're from very different sources to the LIGO and Virgo sources, which are stellar mass black holes and neutron star mergers," Scott Ransom, a National Radio Astronomy Observatory astronomer and former chair of NANOGrav, told Space.com... Ransom is part of a collaboration of researchers that believe low-frequency gravitational waves, including those detected by NANOGrav, may originate from a pretty incredible source. They could come from, the team argues, hundreds of thousands of supermassive black hole pairings that, over the 13.8-billion-year course of cosmic history, came close enough together that they've merged...

"For many decades, theorists have hypothesized that supermassive black hole binaries should produce a signal with characteristics just like what NANOGrav and other pulsar timing arrays are seeing," Luke Zoltan Kelly, a Northwestern University theoretical astrophysicist and NANOGrav researcher, told Space.com. "For most of the community, supermassive black hole binaries are a natural best guess for what's producing the gravitational wave background...." Zoltan Kelley pointed out to Space.com that besides binaries, there are a number of new models in cosmology and in particle physics that, under the right circumstances, could also produce a similar gravitational wave background to that detected by NANOGrav. For example, axion or 'fuzzy' dark matter, cosmic strings, inflationary phase transitions, and many others," the Northwestern astrophysicist said.

"What's really exciting about these possibilities is that each of these models is an attempt to explain some of the biggest current mysteries of our universe."

Science

Why Was Silicon Valley So Obsessed with LK-99 Superconductor Claims? (msn.com) 78

What to make of the news that early research appears unable to duplicate the much-ballyhooed claims for the LK99 superconductor?

"The episode revealed the intense appetite in Silicon Valley for finding the next big thing," argues the Washington Post, "after years of hand-wringing that the tech world has lost its ability to come up with big, world-changing innovations, instead channeling all its money and energy into building new variations of social media apps and business software..." [M]any tech leaders are nervous that the current focus on consumer and business software has led to stagnation. A decade ago, investors prophesied that self-driving cars would take over the roads by the mid-2020s — but they are still firmly in the testing phase, despite billions of dollars of investment. Cryptocurrencies and blockchain technology have had multiple hype cycles of their own, but have yet to fundamentally change any industry, besides crime and money laundering. Tech meant to help mitigate climate change, like carbon capture and storage, has lagged without major advances in years. Meanwhile, Big Tech companies used their huge cash hoards to snap up smaller competitors, with antitrust regulators only recently beginning to clamp down on consolidation. Over the last year, as higher interest rates have cut into the amount of venture capital and slowing growth has caused companies to pull back spending, a massive wave of layoffs has swept the industry, and companies such as Google that previously said they'd invest some of their profits in big, risky ideas have turned away from such "moonshots..."

Room-temperature superconductors would be especially relevant to the tech industry right now, which is busy burning billions of dollars on new computer chips and the energy costs to run them to train the AI models behind tools like ChatGPT and Google's Bard. For years, computer chips have gotten smaller and more efficient, but that progress has run up against the limits of the physical world as transistors get so small some are now just one atom thick.

Science

Common Alzheimer's Disease Gene May Have Helped Our Ancestors Have More Kids (science.org) 40

Science magazine reports: Roughly one in five people are born with at least one copy of a gene variant called APOE4 that makes them more prone to heart disease and Alzheimer's disease in old age. That the variant is so common poses an evolutionary mystery: If it decreases our fitness, why hasn't APOE4 been purged from the human population over time?

Now, a study of nearly 800 women in a traditional society in the Amazon finds that those with the disease-promoting variant had slightly more children. Such a fertility benefit may have allowed the gene to persist during human evolution despite its harmful effects for older people today...

The Tsimané data also allowed the team to home in on how APOE4 may boost fertility: Women carrying it were slightly heavier that those without it, started bearing children about 1 year earlier, and had their next child a few months sooner. That fits with being more resistant to parasites, says siological anthropologist Benjamin Trumble . "Being in a better immune state means that you can then devote more calories towards growing faster, and then you're able to reproduce faster."

Thanks to Slashdot reader sciencehabit for sharing the article.
Space

How to Turn an Asteroid into a Space Habitat (Using Self-Replicating Spider Robots) (sciencealert.com) 65

A retired Technical Fellow from Rockwell Collins "released a 65-page paper that details an easy-to-understand, relatively inexpensive, and feasible plan to turn an asteroid into a space habitat," reports Universe Today (in an article republished at Science Alert): Dr. David W. Jensen breaks the discussion into three main categories — asteroid selection, habitat style selection, and mission strategy to get there (i.e., what robots to use)... He eventually settled on a torus as the ideal habitat type and then dives into calculations about the overall station mass, how to support the inner wall with massive columns, and how to allocate floor space.

All important, but how exactly would we build such a massive behemoth? Self-replicating robots are Dr. Jensen's answer. The report's third section details a plan to utilize spider robots and a base station that can replicate themselves. He stresses the importance of only sending the most advanced technical components from Earth and using materials on the asteroid itself to build everything else, from rock grinders to solar panels...

With admittedly "back-of-the-envelope" calculations, Dr. Jensen estimates that the program would cost only $4.1 billion. That is far less than the $93 billion NASA plans to spend on the Apollo program. And the result would be a space habitat that provides 1 billion square meters of land that didn't exist before. That's a total cost of $4.10 per square meter to build land — in space. Possibly even more impressive is the timeline — Dr. Jensen estimates that the entire construction project could be done in as little as 12 years. However, it will still take longer to fill the habitat with air and water and start regulating its temperature.

Medicine

New Nanophotonic Sample-Testing Chip Could Detect Multiple Viruses or Cancers In Minutes (science.org) 8

Science magazine reports: Researchers have shown how to conduct thousands of rapid molecular screenings simultaneously, using light to identify target molecules snared on top of an array of tiny silicon blocks. In theory, the tool could be used to spot 160,000 different molecules in a single square centimeter of space. Developed to spot gene fragments from the SARS-CoV-2 virus and other infectious organisms, the technology should also be able to identify protein markers of cancer and small molecules flagging toxic threats in the environment...

"[P]revious sensors have not been able to detect a wide range of target molecules," from very low to very high abundance, says Jennifer Dionne, an applied physicist at Stanford University. In hopes of getting around these problems, Dionne and her colleagues turned to an optical detection approach that relies on metasurfaces, arrays of tiny silicon boxes — each roughly 500 nanometers high, 600 nanometers long, and 160 nanometers wide — that focus near-infrared light on their top surface. This focusing makes it easy for a simple optical microscope to detect the shift in the wavelength of light coming from each silicon block, which varies depending on what molecules sit on top...

[T]he technique could allow doctors to detect viral infections without first having to amplify the genetic material from a patient, Dionne says. Perhaps as important, she notes, an array can be designed to reveal how much target DNA has bound, making it possible to detect in minutes not just whether a particular virus is present, but how intense the infection is. Such information could help doctors tailor their treatments. Current tests can also do this, but they normally take several hours to amplify the genetic material and quantify the results.

Dionne and her colleagues have formed a company called Pumpkinseed Bio to commercialize their new detectors, specifically aimed at detecting minute levels of proteins and other molecules that can't readily be amplified to make them easier to detect. And because only a small number of silicon blocks would be needed to spot individual target molecules, researchers should be able to craft arrays to track a multitude of disease biomarkers simultaneously. "We hope to look at many disease states at the same time," says Jack Hu, a former graduate student in Dionne's lab and head of the new startup. "That's the vision."

Thanks to Slashdot reader sciencehabit for sharing the article.
Earth

For Carbon-Capture Experiment, Researchers Dye Canada's Halifax Harbor Pink (ctvnews.ca) 40

The CBC reports that "Some parts of the Halifax harbour turned a bright shade of pink on Thursday — for science."

After researchers dumped in 500 litres of safe, water-soluble dye, "boats, drones and underwater robots were then deployed to map the movement of the dye, so researchers can understand where materials spread and how quickly they do so." The CTV calls it "part of long-term research project that could help reverse some of the world's greenhouse gas emissions" by Dalhousie University and the climate-solutions research organization Planetary Technologies: The move is the first step, says Katja Fennel, an oceanographer at Dalhousie, before researchers release alkaline material into the water this fall. That material will effectively act as an antacid for the ocean, helping to neutralize the additional acidic carbon dioxide being absorbed by the world's oceans. "The purpose is to actually induce the ocean to take up atmospheric CO2 — CO2 from the air — and help us reduce legacy carbon dioxide emissions to the atmosphere," Fennel told CTV News.
To track the uptake of carbon dioxide, researchers need to account for the movement of water. So "The ultimate goal here is to test an idea for a technology that would help us reduce atmospheric CO2," one oceanographer leading the research told the CBC, "and could be one tool in the toolbox for fighting climate change..."

They point out that the ocean holds 50 times as much CO2 as is in the atmosphere, and call the experiment "cutting edge...world-leading research... Ocean alkalinity enhancement has the greatest potential, actually, in terms of storing carbon permanently and safely at a scale that is relevant for global climate."

Thanks to long-time Slashdot reader Baron_Yam for sharing the article.
Science

'Data Have Spoken... LK-99 is Not a Superconductor,' Says US Research Center (theverge.com) 102

The Verge writes that "LK-99 hasn't turned out to be the miraculous superconductor some people initially claimed it was..." [T]he results so far indicate that LK-99 is not a superconductor, at room temperature or otherwise. A slew of research groups have released studies that counter claims originally made about LK-99. "With a great deal of sadness, we now believe that the game is over. LK99 is NOT a superconductor, not even at room temperatures (or at very low temperatures). It is a very highly resistive poor quality material. Period. No point in fighting with the truth," the University of Maryland's Condensed Matter Theory Center (CMTC) posted on August 7th... [The last words of their tweet? "Data have spoken."]

Labs hurriedly published their own results on ArXiv, the same server for preprints (papers that haven't undergone peer review) where the original papers on LK-99 first appeared. Now, a body of evidence has piled up that disproves claims about LK-99. "There is no sign of superconductivity in LK-99 at room temperature," says one preprint from the CSIR-National Physical Laboratory in India. (That was one of the papers cited by the University of Maryland's Condensed Matter Theory Center this week when it posted that "the game is over....") [H]opes that levitation meant that LK-99 is a superconductor were dashed this week after another preprint posed another explanation for why the material might float. The International Center for Quantum Materials in China found evidence that the material is ferromagnetic. That means it can be magnetized and then attracted or repelled by other magnetic materials (iron, for example, is ferromagnetic)...

[T]here are already well over a dozen papers on ArXiv casting doubt on LK-99. "There may be room temperature superconductors to find, but this does not seem to be one," Chris Grovenor, professor of materials at the University of Oxford and director of the Centre for Applied Superconductivity, tells The Verge in an email.

The Washington Post reports that one of physicists who co-authored the discovery paper "countered in an email that other research groups' failure to replicate their results are probably because they lack 'know how' in developing the sample the same way."
Biotech

Scientists Genetically Engineer Bacteria To Detect Cancer Cells (reuters.com) 20

An international team of scientists has developed a new technology that can help detect (or even treat) cancer in hard-to-reach places, such as the colon. The team has published a paper in Science for the technique dubbed CATCH, or cellular assay for targeted, CRISPR-discriminated horizontal gene transfer. Engadget reports: For their lab experiments, the scientists used a species of bacterium called Acinetobacter baylyi. This bacterium has the ability to naturally take up free-floating DNA from its surroundings and then integrate it into its own genome, allowing it to produce new protein for growth. What the scientists did was engineer A. baylyi bacteria so that they'd contain long sequences of DNA mirroring the DNA found in human cancer cells. These sequences serve as some sort of one-half of a zipper that locks on to captured cancer DNA. For their tests, the scientists focus on the mutated KRAS gene that's commonly found in colorectal tumors. If an A. baylyi bacterium finds a mutated DNA and integrates it into its genome, a linked antibiotic resistance gene also gets activated. That's what the team used to confirm the presence of cancer cells: After all, only bacteria with active antibiotic resistance could grow on culture plates filled with antibiotics.

While the scientists were successfully able to detect tumor DNA in mice injected with colorectal cancer cells in the lab, the technology is still not ready to be used for actual diagnosis. The team said it's still working on the next steps, including improving the technique's efficiency and evaluating how it performs compared to other diagnostic tests. In the future, the technology could also be used for targeted biological therapy that can deploy treatment to specific parts of the body based on the presence of certain DNA sequences.

Space

Planetary Defense Test Deflected An Asteroid But Unleashed a Boulder Swarm (ucla.edu) 63

A UCLA-led study of NASA's DART mission found that the collision launched a cloud of boulders from its surface. "The boulder swarm is like a cloud of shrapnel expanding from a hand grenade," said Jewitt, lead author of the study and a UCLA professor of earth and planetary sciences. "Because those big boulders basically share the speed of the targeted asteroid, they're capable of doing their own damage." From a news release: In September 2022, NASA deliberately slammed a spacecraft into the asteroid Dimorphos to knock it slightly off course. NASA's objective was to evaluate whether the strategy could be used to protect Earth in the event that an asteroid was headed toward our planet. Jewitt said that given the high speed of a typical impact, a 15-foot boulder hitting Earth would deliver as much energy as the atomic bomb that was dropped on Hiroshima. Fortunately, neither Dimorphos nor the boulder swarm have ever posed any danger to Earth. NASA chose Dimorphos because it was about 6 million miles from Earth and measured just 581 feet across -- close enough to be of interest and small enough, engineers reasoned, that the half-ton Double Asteroid Redirection Test, or DART, planetary defense spacecraft would be able to change the asteroid's trajectory.

When it hurtled into Dimorphos at 13,000 miles per hour, DART slowed Dimorphos' orbit around its twin asteroid, Didymos, by a few millimeters per second. But, according to images taken by NASA's Hubble Space Telescope, the collision also shook off 37 boulders, each measuring from 3 to 22 feet across. None of the boulders is on a course to hit Earth, but if rubble from a future asteroid deflection were to reach our planet, Jewitt said, they'd hit at the same speed the asteroid was traveling -- fast enough to cause tremendous damage. The research, published in the Astrophysical Journal Letters, found that the rocks were likely knocked off the surface by the shock of the impact. A close-up photograph taken by DART just two seconds before the collision shows a similar number of boulders sitting on the asteroid's surface -- and of similar sizes and shapes -- to the ones that were imaged by the Hubble telescope. The boulders that the scientists studied, among the faintest objects ever seen within the solar system, are observable in detail thanks to the powerful Hubble telescope.

Moon

Russia's Luna 25 Mission Launches To the Moon (cnn.com) 60

Russia has successfully launched Luna 25, the country's first lunar lander in 47 years. From a report: The uncrewed spacecraft lifted off from the Vostochny Cosmodrome in Amur Oblast, Russia. Hitching a ride aboard a Soyuz-2 Fregat rocket, Luna 25 took flight at 8:10 a.m. local time Friday, or 7:10 p.m. ET Thursday. Residents of a Russian village were temporarily evacuated Friday morning since there is a "one in a million chance" that one of Luna 25's rocket stages could fall there, according to Reuters.

The spacecraft is expected to first enter an orbit around Earth before transferring to a lunar orbit and ultimately descending to the surface of the moon. Russia's last lunar lander, Luna 24, landed on the moon on August 18, 1976. Luna 25 and India's Chandrayaan-3 mission, which launched in mid-July, are both expected to land at the lunar south pole on August 23, and it's a race to see which country will land first, according to Reuters. But Roscomos said the two missions are not expected to cause a problem for each other because their specific landing zones differ, Reuters reported.

Mars

Mars Rover Finds Signs of Seasonal Floods (arstechnica.com) 12

NASA's Curiosity rover has discovered signs of seasonal floods on Mars at a site called Gale Crater. Ars Technica reports: About 3,000 Martian days into its exploration, the rover was at a site that dates to roughly 3.6 billion years ago, during Mars' relatively wet Hesperian period. And it came across what would be familiar to gamers as a hex grid: hundreds of hexagonal shaped rock deposits in the area of a few centimeters across and at least 10 centimeters deep. These features are small enough that they'd be easy to overlook as simply another collection of wind-swept debris on the red planet. But up close, they're striking: large collections of hexagons that share sides, creating a regular grid. While there's some irregularity, the lines separating them largely form three-way intersections with equal angles between each line. And, in places where erosion has had different effects on nearby instances, it's clear that individual hexagons are at least 10 centimeters in height.

Similar shapes have been seen on Pluto, formed by convection of an icy surface. But these are far, far larger, able to be detected from a considerable distance from Pluto. The tiny size of the hexes on Mars is completely incompatible with convection. Instead, it has to be the product of mud drying out, creating cracks as the material contracts. The water itself could either come externally, in the form of a flood, or via groundwater that soaks up to the surface. But again, the tiny size of these features is decisive, indicating that only the top few centimeters got wet, which is incompatible with a groundwater source. To form the regular, hexagonal shapes also means repeated cycles -- experiments show that at least a dozen cycles are needed before you start to get the equal angles at the junction.

So, simply based on their shape, it appears that these hexagons are the product of repeated flooding. The chemistry backs this up. The rocks in the lines that separate individual hexagons are largely a mixture of calcium and magnesium sulfates, which will readily precipitate out of water as conditions get drier. These deposits will form harder rocks than the dried mud that comprises the bulk of the hexagons. The researchers behind the work note that the apparently regular, mild wet/dry cycling is incompatible with a lot of ideas about the source of water in Mars' past, such as volcanic melting of ice deposits. Instead, it's consistent with mild seasonal flooding, although there's no way to tell if the cadence was tied to Mars' orbit given what we currently know.
The findings have been published in the journal Nature.
Science

Scientists At Fermilab Close In On Fifth Force of Nature (bbc.com) 84

An anonymous reader quotes a report from the BBC: Scientists near Chicago say they may be getting closer to discovering the existence of a new force of nature. They have found more evidence that sub-atomic particles, called muons, are not behaving in the way predicted by the current theory of sub-atomic physics. Scientists believe that an unknown force could be acting on the muons. More data will be needed to confirm these results, but if they are verified, it could mark the beginning of a revolution in physics.

All of the forces we experience every day can be reduced to just four categories: gravity, electromagnetism, the strong force and the weak force. These four fundamental forces govern how all the objects and particles in the Universe interact with each other. The findings have been made at a US particle accelerator facility called Fermilab. They build on results announced in 2021 in which the Fermilab team first suggested the possibility of a fifth force of nature. Since then, the research team has gathered more data and reduced the uncertainty of their measurements by a factor of two, according to Dr Brendan Casey, a senior scientist at Fermilab. "We're really probing new territory. We're determining the (measurements) at a better precision than it has ever been seen before."

In an experiment with the catchy name 'g minus two (g-2)' the researchers accelerate the sub-atomic particles called muons around a 50-foot-diameter ring, where they are circulated about 1,000 times at nearly the speed of light. The researchers found that they might be behaving in a way that can't be explained by the current theory, which is called the Standard Model, because of the influence of a new force of nature. Although the evidence is strong, the Fermilab team hasn't yet got conclusive proof. They had hoped to have it by now, but uncertainties in what the standard model says the amount of wobbling in muons should be, has increased, because of developments in theoretical physics. In essence, the goal posts have been moved for the experimental physicists. The researchers believe that they will have the data they need, and that the theoretical uncertainty will have narrowed in two years' time sufficiently for them to get their goal. That said, a rival team at Europe's Large Hadron Collider (LHC) are hoping to get there first.
The results have been announced to the public and submitted to the Journal Physical Review Letters.
Earth

Early Humans Wiped Out in Europe By 'Glacial Cooling,' Study Suggests 61

Extreme "glacial cooling" that occurred more than a million years ago in southern Europe is likely to have caused an "extinction of early humans" on the continent, according to new research. From a report: The previously unknown ice age pushed the European climate to "beyond what archaic humans could tolerate" and likely wiped out human life on the continent temporarily, concluded an academic paper published in the journal Science. The findings by 11 researchers from institutions including University College London and the University of Cambridge challenge the long-held idea that humans have continuously occupied Europe since first arriving in the region.

The newly discovered cooling event was "comparable to some of the most severe events of recent ice ages," said the paper's lead author Vasiliki Margari from UCL. "We suggest that these extreme conditions led to the depopulation of Europe," the researchers concluded. Glacial-interglacial cycles, or warmer and colder periods each lasting thousands of years, have occurred cyclically over the past 2.6mn years, with large ice sheets forming during the colder spells and melting during the warmer periods. According to the academic paper, a previously unknown glacial period that occurred about 1.1mn years ago led to abrupt cooling that lasted about 4,000 years. This happened as conditions began to warm and large ice sheets melted into the Atlantic Ocean, which pushed down European sea and land temperatures.
Space

Virgin Galactic Successfully Flies Tourists To Space For First Time (theguardian.com) 48

An anonymous reader quotes a report from The Guardian: Virgin Galactic's VSS Unity, the reusable rocket-powered space plane carrying the company's first crew of tourists to space, successfully launched and landed on Thursday. The mission, known as Galactic 02, took off shortly after 11am ET from Spaceport America in New Mexico. Aboard the spacecraft were six individuals total -- the space plane's commander and former Nasa astronaut CJ Sturckow, the pilot Kelly Latimer, as well as Beth Moses, Virgin Galactic's chief astronaut instructor who trained the crew before to the flight. The spacecraft also carried three private passengers, including the health and wellness coach Keisha Schahaff and her 18-year-old daughter, Anastasia Mayers, both of whom are Antiguan. [...]

Galactic 02 is a suborbital flight. However, despite VSS Unity not reaching orbit, the trajectory allows passengers to experience several minutes of weightlessness at an altitude high enough for them to see the Earth's curvature, Space.com explains. Following liftoff, Virgin Galactic's carrier plane VMS Eve transported VSS Unity to an altitude of about 44,300ft. Eve then dropped Unity which then fired its own rocket motor and ascended to suborbital space. Passengers aboard experienced approximately 3Gs. Live footage inside the spacecraft showed the passengers unstrapping themselves from their seats and peering out down to earth through the windows as they floated throughout the spacecraft.

Despite Galactic 02 being Virgin Galactic's second commercial spaceflight mission, it is the first flight to carry private customers. In June, Galactic 01 carried three crew members from the Italian air force and the National Research Council of Italy. According to Virgin Galactic, the company has already booked a backlog of about 800 customers. Tickets have ranged from $250,000 to $450,000. Galactic 03, the company's third commercial spaceflight, is planned for September.

Moon

Russia Hopes For Its First Successful Lunar Landing Mission in Nearly 50 Years (theguardian.com) 143

Russia hopes to launch its first successful lunar landing mission for nearly 50 years, with a long-delayed takeoff from the far east of the country scheduled for early on Friday morning that the Kremlin aims to tout as a new achievement in space exploration. From a report: The Luna-25 mission will seek to land near the south pole of the moon, collecting geological samples from the area, and sending back data for signs of water or its building blocks, which could raise the possibility of a future human colony on the moon. But the more immediate goal is to prove that Russia still can launch a lunar landing mission after numerous failures in the past, generations of turnover among its scientific experts, delays due to sanctions and now isolation due to its war in Ukraine.

Post-Soviet Russia has launched two failed space landing missions, the Mars-96 in 1996 and Phobos-Grunt in 2011, both of which crash-landed into the Pacific Ocean. "The Russian Federation hasn't had much luck with launching unmanned interplanetary probes," said Vitaly Egorov, a blogger who writes extensively on space exploration. "Now 12 years later they're launching Luna-25 and the main intrigue is whether or not it will succeed in reaching [the moon] or not, and if it does, can it actually land there? "One of the main goals is to let modern specialists put down space probes softly on celestial objects. They haven't had that experience in 47 years. That knowledge needs to be restored for new specialists on a new technological level."

Space

Astronomer Claims 'Direct Evidence' of Gravity Breaking Down (vice.com) 118

A scientist has observed a "gravitational anomaly" in certain star systems that could potentially upend a fundamental assumption about the universe, according to a new study. Motherboard reports: Kyu-Hyun Chae, an astronomer at Sejong University, has now put these models to the test by analyzing the accelerations of stars in 26,500 wide binaries located within about 650 light years of Earth using imagery captured by the European Space Agency's Gaia observatory. Scientists have previously searched for signs of modified gravity in these systems, but Chae took the next step by developing a new code that could account for special details, like the occurrence rate of so-called "nested" binaries in which the loosely orbiting stars also have close stellar companions. The new data suggests that when the gravitational accelerations of these stars slip below one nanometer per second squared, they begin to move in ways that are more aligned with MOND models than by the standard model. Chae said the findings offer "direct evidence for the breakdown of standard gravity at weak acceleration" and reveal "an immovable anomaly of gravity in favor of MOND-based modified gravity," according to a recent study published in The Astrophysical Journal.

In the new study, Chae reports what he calls "clear evidence" that the movements of binaries at points of weak acceleration seem to sync up with a particular MOND prediction known as AQUAL, according to the study. This discovery suggests that the standard view of gravity cannot account for these motions at low accelerations, which may inspire scientists to rethink aspects of Newton's inverse square law of gravity and Einstein's general relativity, as well as the necessity of dark matter. "Because a large amount of dark matter -- six times the baryonic or ordinary matter based on the standard model -- was required by assuming that general relativity was valid in the low acceleration limit, such a need for a large amount of dark matter is no longer valid," Chae explained. "This does not necessarily preclude the possibility that new particles, such as sterile neutrinos, could not be found. But, it is clear that there is no need for as much dark matter as required by general relativity."
"When the results started to show up from my new and more reliable code, my initial reaction was that it was unbelievable," Chae said in an email to Motherboard. "I was feeling like I was dreaming. It seemed so unreal. This is because my results did not match any previous results."

"Several previous results even claimed that the standard gravity was preferred by wide binaries data including Gaia DR3. One group has been claiming an anomaly for some time, but the anomaly seemed not to match well the predictions of existing modified gravity theories. However, those previous studies did not self-calibrate or fully take into account the amount of hidden nested binaries."
Science

Crocodiles Are Alarmingly Attuned To the Cries of Human Infants (science.org) 53

sciencehabit shares a report from Science: Whether they're in mortal peril or just suffering from indigestion, infants across the animal kingdom cry out to tell their parents they need help. Unfortunately for them, the parents aren't the only ones attuned to the cries of their vulnerable young. Nile crocodiles are uniquely sensitive to the wails of distressed primate babies, according to a new study -- and the more anxious the cry, the more interested the crocs become. Indeed, according to the research, published today in Proceedings of the Royal Society B: Biological Sciences, the reptiles are even better at identifying the emotional cues hidden in the wails of babies than we are -- perhaps because they've evolved to home in on helpless prey.

To make the gruesome find, Nicolas Grimault, a bioacoustician at the University of Lyon, and colleagues visited a zoo in Agadir, Morocco, that houses more than 300 Nile crocodiles (Crocodylus niloticus) -- a predator particularly well suited to hunting primates and other mammals. The researchers set up loudspeakers alongside four ponds, where, at each, as many as 25 crocodiles sunbathed on red rock ledges. The speakers blared out a series of cries from chimpanzee (Pan troglodytes), bonobo (P. paniscus), and human infants, captured in a variety of situations in order to document a wide range of emotion. The human infants, for example, were recorded both during bath time and vaccination. (You can listen to the sounds yourself in the videos [here].) Many of the crocs, male and female, responded to the cries by seeking out the source of the sound, rapidly approaching the loudspeaker and sometimes even biting it. But their response depended on the characteristics of the cries they heard: Crocs were more likely to respond to recordings with acoustic features known to correlate to highly upset infants such as disharmony, noise bursts, and uneven tones reminiscent of radio static.

The reptiles seemed to be identifying the most distressed prey on the basis of their cries, Grimault says -- a smart strategy for an animal that is a highly opportunistic hunter. "A baby might not scream at the top of its lungs if it's with its mother," Reber adds, "but it might ... if it fell into the water." On average, about one in five crocodiles responded to recordings of human infants experiencing low levels of distress, whereas about one-third responded to the cries of severely distressed human babies. Surprisingly, the crocodiles seemed even better at detecting distress in the cries than humans were. When the researchers asked human volunteers, all of whom had experience with human infants, to listen to the same recorded cries and estimate the level of distress communicated by the sounds, the participants used different features than the crocs did to evaluate the sounds, basing their decisions largely on the pitch of the cries.
The researchers note that it's possible some of the crocodiles were acting out of parental concern, rather than blood lust. "Nile crocodile mothers respond to distress calls from their own young, and their attempts to bite the loudspeaker might not be as bad as they look -- mother crocodiles are known to gingerly pick up their own babies in their jaws."
Science

Heart Attacks Are Rising in Young Adults 194

National Geographic: Research does show that heart attacks, also called myocardial infarctions, are on the rise in younger people. Common symptoms include chest pain or discomfort; pain that radiates into the jaw, neck, back or arms; shortness of breath; and feeling weak or faint. A study of more than 2,000 young adults admitted for heart attack between 2000 and 2016 in two U.S. hospitals found that 1 in 5 were 40 years old or younger -- and that the proportion of this group has been increasing by 2 percent each year for the last decade.

The study, published in 2019 in the American Journal of Medicine, also found that people ages 40 or younger who have had a heart attack are just as likely as older adults to die from another heart attack, stroke, or other reason. In fact, increases in heart disease among younger adults in 2020 and 2021 are responsible for more than 4 percent of the most recent declines in life expectancy in the U.S., according to an editorial published in March in JAMA Network. The problem isn't uniquely American. Research shows that adults in Pakistan and India, for example, are also experiencing heart attacks at younger ages.
Earth

An Unintended Test of Geoengineering is Fueling Record Ocean Warmth (science.org) 62

Researchers are now waking up to another factor why so many places on earth are getting warmer, one that could be filed under the category of unintended consequences: disappearing clouds known as ship tracks. From a report: Regulations imposed in 2020 by the United Nations's International Maritime Organization (IMO) have cut ships' sulfur pollution by more than 80% and improved air quality worldwide. The reduction has also lessened the effect of sulfate particles in seeding and brightening the distinctive low-lying, reflective clouds that follow in the wake of ships and help cool the planet. The 2020 IMO rule "is a big natural experiment," says Duncan Watson-Parris, an atmospheric physicist at the Scripps Institution of Oceanography. "We're changing the clouds."

By dramatically reducing the number of ship tracks, the planet has warmed up faster, several new studies have found. That trend is magnified in the Atlantic, where maritime traffic is particularly dense. In the shipping corridors, the increased light represents a 50% boost to the warming effect of human carbon emissions. It's as if the world suddenly lost the cooling effect from a fairly large volcanic eruption each year, says Michael Diamond, an atmospheric scientist at Florida State University. The natural experiment created by the IMO rules is providing a rare opportunity for climate scientists to study a geoengineering scheme in action -- although it is one that is working in the wrong direction. Indeed, one such strategy to slow global warming, called marine cloud brightening, would see ships inject salt particles back into the air, to make clouds more reflective. In Diamond's view, the dramatic decline in ship tracks is clear evidence that humanity could cool off the planet significantly by brightening the clouds. "It suggests pretty strongly that if you wanted to do it on purpose, you could," he says.

Slashdot Top Deals