Scientists discovered a way to break apart the membranes of cancer cells by stimulating aminocyanine molecules with near-infrared light. Slashdot reader Baron_Yam shares a report from ScienceAlert: The research team from Rice University, Texas A&M University, and the University of Texas, says the new approach is a marked improvement over another kind of cancer-killing molecular machine previously developed, called Feringa-type motors, which could also break the structures of problematic cells. "It is a whole new generation of molecular machines that we call molecular jackhammers," says chemist James Tour from Rice University. "They are more than one million times faster in their mechanical motion than the former Feringa-type motors, and they can be activated with near-infrared light rather than visible light."

In tests on cultured, lab-grown cancer cells, the molecular jackhammer method scored a 99 percent hit rate at destroying the cells. The approach was also tested on mice with melanoma tumors, and half the animals became cancer-free. The structure and chemical properties of aminocyanine molecules mean they stay in sync with the right stimulus -- such as near-infrared light. When in motion, the electrons inside the molecules form what's known as plasmons, collectively vibrating entities that drive movement across the whole of the molecule. The plasmons have an arm on one side, helping to connect the molecules to the cancer cell membranes while the movements of the vibrations bash them apart. It's still early days for the research, but these initial findings are very promising. The research has been published in Nature Chemistry.

AstroForge, a private company, wants to mine a space rock, but it doesn't want the competition to find out which one. From a report: For generations, Western space missions have largely occurred out in the open. We knew where they were going, why they were going there and what they planned to do. But the world is on the verge of a new era in which private interests override such openness, with big money potentially on the line. Sometime in the coming year, a spacecraft from AstroForge, an American asteroid-mining firm, may be launched on a mission to a rocky object near Earth's orbit. If successful, it will be the first wholly commercial deep-space mission beyond the moon. AstroForge, however, is keeping its target asteroid secret.

The secret space-rock mission is the latest in an emerging trend that astronomers and other experts do not welcome: commercial space missions conducted covertly. Such missions highlight gaps in the regulation of spaceflight as well as concerns about whether exploring the cosmos will continue to benefit all humankind. "I'm very much not in favor of having stuff swirling around the inner solar system without anyone knowing where it is," said Jonathan McDowell, an astronomer at the Harvard-Smithsonian Center for Astrophysics in Massachusetts. "It seems like a bad precedent to set." But for AstroForge, the calculation is simple: If it reveals the destination, a competitor may grab the asteroid's valuable metals for itself. "Announcing which asteroid we are targeting opens up risk that another entity could seize that asteroid," said Matt Gialich, AstroForge's chief executive.

From the depths of the Amazon rainforest to the deserts of Antarctica, huge questions remain unanswered about life on Earth. The Guardian asked leading scientists and conservationists: what is the one thing you would like to know about the planet that remains a mystery? TLDR, the questions/wishes are:1. How many species are there on Earth?
2. I'd go back 540m years to see the 'biological big bang'
3. Could some of the smallest life forms help avert climate crisis?
4. What is the full biodiversity of the Amazon or Congo basin rainforests?
5. How do animals influence the functioning of Earth?
6. What will happen to the Gulf Stream?
7. Do universal rules govern how plants and animals evolve?
8. How many humans could Earth support?
9. Which species will adapt to the climate crisis -- and which will not?

Abstract of a paper published on the American Psychological Association: People are frequently invited to join others for fun social activities. They may be invited to lunch, to attend a sporting event, to watch the season finale of a television show, and so forth. Invitees -- those who are on the receiving ends of invitations -- sometimes accept invitations from inviters -- those who extend invitations -- but other times, invitees decline. Unfortunately, saying no can be hard, leading invitees to accept invitations when they would rather not. The present work sheds light on one factor that makes it so hard to decline invitations.

We demonstrate that invitees overestimate the negative ramifications that arise in the eyes of inviters following an invitation decline. Invitees have exaggerated concerns about how much the decline will anger the inviter, signal that the invitee does not care about the inviter, make the inviter unlikely to offer another invitation in the future, and so forth. We also demonstrate that this asymmetry emerges in part because invitees exaggerate the degree to which inviters focus on the decline itself, as opposed to the thoughts ran through the invitee's head before deciding. Indeed, across multiple studies, we find support for this process through mediation and moderation, while simultaneously finding evidence against multiple alternative accounts. We conclude with a discussion of the contributions and limitations of this research, along with directions for future work.

"It's like visiting an old friend for the holidays," according to this article: Approaching his 86th birthday, Donald Knuth — Stanford's beloved computer science guru — honored what's become a long-standing tradition. He gave a December "Christmas lecture" that's also streamed online for all of his fans...

More than 60 years ago, back in 1962, a 24-year-old Donald Knuth first started writing The Art of Computer Programming — a comprehensive analysis of algorithms which, here in 2023, he's still trying to finish. And 30 years ago Knuth also began making rare live appearances each December in front of audiences of Stanford students...

Recently Stanford uploaded several decades of Knuth's past Christmas lectures, along with a series of 22 videos of Knuth from 1985 titled "the 'Aha' Sessions'" (courses in mathematical problem-solving). There are also two different sets of five videos from 1981 showing Knuth introducing his newly-created typesetting system TeX. There are even 12 videos from 1982 of what Knuth calls "an intensive course about the internal details."

And on Dec. 6, wearing his traditional brown holiday sweater, Knuth gave yet another live demonstration of the beautifully clear precision that's made him famous.

"The age of the dinosaurs ended 66 million years ago when a city-size asteroid struck a shallow sea off the coast of what is now Mexico," writes CNN.

"But exactly how the mass extinction of 75% of the species on Earth unfolded in the years that followed the cataclysmic impact has remained unclear." Previous research suggested that sulfur released during the impact, which left the 112-mile-wide (180-kilometer-wide) Chicxulub crater, and soot from wildfires triggered a global winter, and temperatures plunged. However, a new study published Monday in the journal Nature Geoscience suggests that fine dust made from pulverized rock thrown up into Earth's atmosphere in the wake of the impact likely played a greater role. This dust blocked the sun to an extent that plants were unable to photosynthesize, a biological process critical for life, for almost two years afterward.

"Photosynthesis shutting down for almost two years after impact caused severe challenges (for life)," said lead study author and planetary scientist Cem Berk Senel, a postdoctoral researcher at the Royal Observatory of Belgium. "It collapsed the food web, creating a chain reaction of extinctions."

To reach their findings, scientists developed a new computer model to simulate the global climate after the asteroid strike. The model was based on published information on Earth's climate at that point in time, as well as new data from sediment samples taken from the Tanis fossil site in North Dakota that captured a 20-year period during the aftermath of the strike.

Slashdot reader sciencehabit writes: If you've ever seen a cow staring vacantly across a field, or a pig rolling around in its own filth, you might not think there's a lot going on in their head. You wouldn't be alone. People haven't given much credence to the intelligence of farm animals, and neither have scientists. But that's starting to change.

A growing field of research is showing that—when it comes to the minds of goats, cows, and other livestock—we may have been missing something big. Studies published over the past few years have shown that pigs show signs of empathy, goats rival dogs in some tests of social intelligence, and cows can be potty trained.

Much of this work is being carried out at the Research Institute for Farm Animal Biology (FBN) in Dummerstorf, Germany, one of the world's leading centers for investigating the minds of creatures that often end up on our dinner plate. From cows making friends to goats exhibiting signs of altruism, farm animals are upending popular—and scientific—conceptions of what's going on in their minds.

The work may not just rewrite our thinking about livestock, it might also change how we treat them. As Jan Langbein, an applied ethologist at FBN told says, 'If we don't understand how these animals think, then we won't understand what they need. And if we don't understand what they need, we can't design better environments for them.'

The New Yorker looks at 41-year-old Amabel Holland, an autistic board-game designer who "thinks about the world in terms of systems," and realized you could make a board game about almost anything, "and, when you did, its rules could both mirror and analyze the subject on which it was based."

They've since designed more than 60 games, and the article notes that Holland's work, "which is part of a larger turn toward complexity in the industry, often tackles historical and social subjects — death, religion, misinformation — using surprising 'mechanics,' or building blocks of game play, to immerse players in an experience." "With every game, you build a certain model of the world," Reiner Knizia, a former mathematician who's designed more than eight hundred games, told me. Several of his games illustrate market forces: in Modern Art, for instance, you play as auctioneers and buyers, hoping to buy low and sell high. Knizia is a traditional game designer inasmuch as he aims to "bring enjoyment to the people." But Amabel sometimes aims for the opposite of enjoyment... This Guilty Land, from 2018, is about the struggle to end slavery."
Holland says their games are "meant to evoke frustration" — specifically to communicate how difficult it can be to actually achieve political progress.

Thanks to Slashdot reader silverjacket for sharing the article.

Scientists have developed a vibrating pill that, when swallowed before eating, can create a feeling of fullness. The Guardian reports: The research, which has yet to be carried out in humans, shows that after 30 minutes of activity by the Vibes pill, pigs ate on average almost 40% less food in the following half hour than they did without the device, and gained weight more slowly. The Vibes name is an acronym derived from the pill's full title -- Vibrating Ingestible BioElectronic Stimulator. The work in pigs suggests the vibrations activate stretch receptors in the stomach, simulating the presence of food. This results in signals being sent to the hypothalamus in the brain via the vagus nerve, increasing levels of various hormones that give rise to a feeling of fullness and decreasing those that result in feelings of hunger.

"We envision the Vibes pill being ingested on a relatively empty stomach 20 to 30 min before anticipated meals to trigger the desired sensation of satiety early in the meal,â the team write, adding that when produced at scale, the cost of the pills is expected to be in the cents to one dollar range. The vibrations, which are powered by a battery encased in the swallowed capsule, can be triggered when stomach acid dissolves a membrane around the pill, or by a timer. The researchers say the pills, which are about the size of a large vitamin tablet, offer a non-invasive, temporary therapy, without the need for weight-loss surgery, and exit the body with other solid waste -- meaning in humans they are flushed down the toilet. However they suggest it could be possible to develop pills that are implanted, or stay in the stomach, to reduce the need for people to repeatedly take them, should they require continuing therapy. Further reading: Man Reports PillCam Stuck In His Gut For Over 12 Weeks

An anonymous reader quotes a report from The Guardian: From empty glasses of sherry on the mantelpiece to sooty footprints leading to the bedroom door, evidence of Santa's existence is clearly irrefutable. Yet most children will begin to question it at some point -- and many parents anticipate this moment with dread. Now psychologists have identified the average age when Santa skepticism creeps in, and which children are at greatest risk of harboring negative feelings when it does.

While most adults have fallen for the myth that Santa doesn't exist, many children still believe -- even if the idea of a single individual visiting the homes of billions of children in a single night is at odds with their wider reasoning skills. Dr Candice Mills, a psychologist at the University of Texas in Dallas, US, and a Santa sceptic, said: "Children typically begin to distinguish fantasy from reality during the preschool years, but their belief in the existence of a singular magical Santa Claus often continues into middle childhood." [...] To better understand this shift from belief to disbelief and children's experiences of it, Mills and her colleagues interviewed 48 six- to 15-year-olds who had stopped believing in Santa and 44 of their parents, plus a further 383 adults.

The research, which has not yet been peer reviewed, found that for most children, disbelief crept in gradually about the age of eight -- although some three- or four-year-olds had convinced themselves that Santa wasn't real, while other children believed in him until they were 15 or 16. In many cases, it was testimony from other disbelievers that finally crushed their faith. Mills said: "They may have had some skepticism based on logical reasoning -- like how can Santa Claus really get around the world in one night? -- but what pushes them over the edge is a classmate at school saying he's not real."

An anonymous reader shares a report: It may be the season of loving and giving, but doctors have warned against embracing this spirit too enthusiastically -- at least where sexual relations are concerned. They have discovered that the Christmas period is associated with a significantly increased risk of penile fractures -- a medical emergency in which the erection-producing regions of the penis snap, usually as a result of forceful bending during over-enthusiastic sexual intercourse. "This injury tends to occur during wild sex -- particularly in positions where you're not in direct eye contact [with your partner], such as the reverse cowgirl," said Dr Nikolaos Pyrgides, a urologist at the Ludwig Maximilian University of Munich, who led the research.

The fractures are often heralded by an audible crack, followed by severe pain, rapid loss of erection and severe swelling and bruising. "When [patients] present to their doctor their penis often looks like an eggplant," Pyrgides said. Suspecting that the intimacy and euphoria of the festive season might be a risk factor for this type of injury, Pyrgides and his colleagues examined hospital data for 3,421 men who sustained penile fractures in Germany between 2005 and 2021. The study -- the first to explore seasonal patterns for this type of injury -- found that such injuries were indeed more common over Christmas. In fact, "if every day was like Christmas, 43% more penile fractures would have occurred in Germany from 2005 on," Pyrgides said. The research, which was published in the British Journal of Urology International, also found the risk increased at weekends and over the summer holidays. However, New Year's Eve was not associated with an increased incidence of penis injuries.

In 2005, the reclassification of pseudoephedrine to behind-the-counter status led to widespread use of oral phenylephrine in OTC decongestants, despite evidence of its ineffectiveness. Randy Hatton, a clinical professor in the College of Pharmacy at the University of Florida, and his colleague worked to bring this issue to the FDA's attention, revealing loopholes in the regulatory process for older OTC drugs. Hatton writes in an opinion piece for Scientific American: Before the FDA required that drugs had to be proven effective, it determined whether OTC drugs were effective through expert panels that reviewed existing data. These OTC monographs establish what older OTC ingredients can be marketed without FDA approval. The oral decongestant monograph panel reviewed a few published studies and multiple unpublished studies for phenylephrine. Of the unpublished studies, only four studies showed oral phenylephrine was effective, while seven showed it was no better than placebo. We requested copies of all evidence used by the nasal decongestant review panel via a Freedom of Information Act request and performed a systematic review and meta-analysis ourselves. [...]

The FDA has multiple regulatory processes for different types of medicinal compounds. People are perhaps most familiar with the New Drug Application process, which leads to clinical trials for prescription drug approvals. However, many OTC or nonprescription drugs are regulated differently. In fact, a law passed in 1951, the Durham-Humphrey Amendment to the 1938 Food, Drug, and Cosmetic Act, created the categories of prescription and nonprescription drugs. In 1962, the act was amended again so that drugs had to be shown to be effective, hence the requirement for well-done clinical trials. But what about the drugs that were approved before 1962? This is the loophole that some OTC drugs fall through. For prescription drugs, FDA tried to address pre-1962 approvals through a review of over 3,000 prescription drugs. Most of those drugs have now been reviewed and addressed, but there are still unapproved prescription drugs on the market today, such as an extended-release form of oral nitroglycerin. For nonprescription drugs, FDA established the OTC monograph process 10 years after the 1962 amendment to the Food, Drug, and Cosmetic Act, which required products not proven effective to be reconsidered. FDA formed advisory panels grouping hundreds of ingredients into 26 categories based on the products' uses. After gathering all available information, both published and unpublished, from manufacturers, the advisory panels issued final reports to FDA about whether these ingredients were GRASE (generally recognized as safe and effective), not GRASE, or inconclusive. GRASE ingredients can be used in nonprescription drugs without FDA approval if the use matches the monograph. "The oral phenylephrine example shows that FDA needs more funding to look at these old drugs," concludes Hatton. "We need public funds to support independent researchers who want to examine these products objectively. The government should be able to spend millions to save consumers billions on ineffective products. Companies that market these products have no incentive to prove they don't work. Nonprescription drugs must be effective -- not just safe."

During a meeting of the National Space Council, Vice President Kamala Harris said an international astronaut will land on the Moon during one of NASA's Artemis missions. "Today, in recognition of the essential role that our allies and partners play in the Artemis program, I am proud to announce that alongside American astronauts, we intend to land an international astronaut on the surface of the Moon by the end of the decade," Harris said. Ars Technica reports: Although the National Space Council is useful in aggregating disparate interests across the US government to help form more cohesive space policies, public meetings like the one Wednesday can seem perfunctory. Harris departed the stage soon after her speech, and other government officials read from prepared remarks during the rest of the event. Nevertheless, Harris' announcement highlighted the role the space program plays in elevating the soft power of the United States. It was widely assumed an international astronaut would eventually land on the Moon with NASA. Harris put a deadline on achieving this goal.

NASA has long included astronauts from its international partners on human spaceflight missions, dating back to the ninth flight of the space shuttle in 1983, when West German astronaut Ulf Merbold joined five Americans on a flight to low-Earth orbit. This was seen by US government officials as a way to foster closer relations with like-minded countries. The inclusion of foreign astronauts on US missions also repays partner nations who make financial commitments to US-led space projects with a high-profile flight opportunity for one of their citizens.

Among the international partners contributing to Artemis, it seems most likely a European astronaut would get the first slot for a landing with NASA. ESA funded the development of the service modules used on NASA's Orion spacecraft, which will ferry astronauts from Earth to the Moon and back. These modules provide power and propulsion for Orion. ESA is also developing refueling and communications infrastructure for the Gateway mini-space station to be constructed in orbit around the Moon.

A Japanese astronaut might also have a shot at getting a seat on an Artemis landing. Japan's government has committed to providing the life-support system for the Gateway's international habitation module, along with resupply services to deliver cargo to Gateway. Japan is also interested in building a pressurized rover for astronauts to drive across the lunar surface. In recognition of Japan's contributions, NASA last year committed to flying a Japanese astronaut aboard Gateway. Canada is building a robotic arm for Gateway, but a Canadian astronaut already has a seat on NASA's first crewed Artemis mission, albeit without a trip to the lunar surface.

An anonymous reader quotes a report from the Los Angeles Times: It was the late 1980s when Gary Mund felt his pinky tremble. At first it seemed like a random occurrence, but pretty quickly he realized something was seriously wrong. Within two years, Mund -- a crew worker with the Eastern Municipal Water District in Riverside County -- was diagnosed with Parkinson's disease. The illness would eventually consume much of his life, clouding his speech, zapping most of his motor skills and taking away his ability to work and drive. "It sucks," said Mund, 69. He speaks tersely, because every word is a hard-won battle. "I was told the herbicide wouldn't hurt you."

The herbicide is paraquat, an extremely powerful weed killer that Mund sprayed on vegetation as part of his job from about 1980 to 1985. Mund contends the product is responsible for his disease, but the manufacturer denies there is a causal link between the chemical and Parkinson's. Paraquat is manufactured by Syngenta, a Swiss-based company owned by the Chinese government. The chemical is banned in at least 58 countries -- including China and Switzerland -- due to its toxicity, yet it continues to be a popular herbicide in California and other parts of the United States. But research suggests the chemical may cross the blood-brain barrier in a manner that triggers Parkinson's disease, a progressive, neurodegenerative disorder that affects movement. Now, Mund is among thousands of workers suing Syngenta seeking damages and hoping to see the chemical banned.

Since 2017, more than 3,600 lawsuits have been filed in state and federal courts seeking damages from exposure to paraquat products, according to Syngenta's 2022 financial report (PDF). [...] Paraquat is 28 times more toxic than another controversial herbicide, Roundup, according to a report from the Pesticide Action Network. (Roundup has been banned in several parts of California, including a 2019 moratorium by the Los Angeles County Board of Supervisors forbidding its use by county departments.) Paraquat also has other known health effects. It is listed as "highly toxic" on the U.S. Environmental Protection Agency's website, which says that "one small sip can be fatal and there is no antidote." The EPA is currently reviewing paraquat's approval status. However, both the EPA and Syngenta cited a 2020 U.S. government Agricultural Health Study that found there is no clear link between paraquat exposure and Parkinson's disease. A 2021 review of reviews similarly found that there is no causal relationship.

An anonymous reader quotes a report from Ars Technica: With redesigned engine components, Blue Origin's New Shepard rocket took off from West Texas and flew to the edge of space on Tuesday with a package of scientific research and technology demonstration experiments. This was the first flight of Blue Origin's 60-foot-tall (18-meter) New Shepard rocket since September 12, 2022, when an engine failure destroyed the booster and triggered an in-flight abort for the vehicle's pressurized capsule. There were no passengers aboard for that mission, and the capsule safely separated from the failed booster and parachuted to a controlled landing.

The flight on Tuesday also didn't carry people. Instead, Blue Origin, Jeff Bezos's space company, lofted 33 payloads from NASA, research institutions, and commercial companies. Some of these payloads were flown again on Tuesday's launch after failing to reach space on the failed New Shepard mission last year. Among these payloads were an experiment to demonstrate hydrogen fuel cell technology in microgravity and an investigation studying the strength of planetary soils under different gravity conditions. Blue Origin's capsule, mounted on top of the rocket, also flew 38,000 postcards submitted by students through Club for the Future, the company's nonprofit.

For Tuesday's return-to-flight mission, the New Shepard rocket ignited its BE-3PM engine and climbed away from Blue Origin's remote launch site near Van Horn, Texas, at 10:42 am CST (16:42 UTC). The hydrogen-fueled engine fired for more than two minutes, then shut down as scheduled as the rocket continued coasting upward, reaching an altitude of more than 347,000 feet (106 kilometers). The booster returned for a precision propulsive landing a short distance from the launch pad, and Blue Origin's capsule deployed three parachutes to settle onto the desert floor, completing a 10-minute up-and-down flight. Blue Origin has launched 24 missions with its reusable New Shepard rocket, including six flights carrying people just over the Karman line, the internationally recognized boundary of space 100 kilometers above Earth.