Health authorities in densely-populated Hong Kong and Singapore have warned that Covid-19 cases are spiking, as a resurgent wave spreads through Asia. Bloomberg: The virus' activity in Hong Kong is now "quite high," Albert Au, head of the Communicable Disease Branch of the city's Center for Health Protection, told local media this week. The percentage of respiratory samples testing Covid-positive in Hong Kong recently reached its highest in a year.

Severe cases -- including deaths -- also reached its highest level in about a year to 31 in the week through May 3, the center's data shows. While the resurgence is yet to match the infection peaks seen in the past two years, rising viral load found in sewage water and Covid-related medical consultations and hospitalizations suggest the virus is actively spreading in the city of over 7 million people.

Rival financial hub Singapore is also on Covid alert. The city-state's health ministry released its first update on infection numbers in almost a year this month, as the estimated number of cases jumped 28% to 14,200 in the week through May 3 from the previous seven days while daily hospitalization rose around 30%. Singapore now only provides case updates when there is a noticeable spike.

MIT said Friday it can no longer stand behind a widely circulated paper on AI written by a doctoral student in its economics program. The paper said that the introduction of an AI tool in a materials-science lab led to gains in new discoveries, but had more ambiguous effects on the scientists who used it. WSJ: MIT didn't name the student in its statement Friday, but it did name the paper. That paper, by Aidan Toner-Rodgers, was covered by The Wall Street Journal and other media outlets. In a press release, MIT said it "has no confidence in the provenance, reliability or validity of the data and has no confidence in the veracity of the research contained in the paper."

The university said the author of the paper is no longer at MIT. The paper said that after an AI tool was implemented at a large materials-science lab, researchers discovered significantly more materials -- a result that suggested that, in certain settings, AI could substantially improve worker productivity. But it also showed that most of the productivity gains went to scientists who were already highly effective, and that overall the AI tool made scientists less happy about their work.

China launched 12 satellites on Wednesday as part of the âoeThree-Body Computing Constellation,â the worldâ(TM)s first dedicated orbital computing network led by ADA Space and Zhejiang Lab. SpaceNews reports: A Long March 2D rocket lifted off at 12:12 a.m. Eastern (0412 UTC) May 14 from Jiuquan Satellite Launch Center in northwest China. Insulation tiles fell away from the payload fairing as the rocket climbed into a clear blue sky above the spaceport. The China Aerospace Science and Technology Corporation (CASC) announced a fully successful launch, revealing the mission to have sent 12 satellites for a space computing constellation into orbit. Commercial company ADA Space released further details, stating that the 12 satellites form the "Three-Body Computing Constellation," which will directly process data in space, rather than on the ground, reducing reliance on ground-based computing infrastructure. The constellation will be capable of a combined 5 peta operations per second (POPS) with 30 terabytes of onboard storage.

The satellites feature advanced AI capabilities, up to 100 Gbps laser inter-satellite links and remote sensing payloads -- data from which will be processed onboard, reducing data transmission requirements. One satellite also carries a cosmic X-ray polarimeter developed by Guangxi University and the National Astronomical Observatories of the Chinese Academy of Sciences (NAOC), which will detect, identify and classify transient events such as gamma-ray bursts, while also triggering messages to enable followup observations by other missions. [...] The company says the constellation can meet the growing demand for real-time computing in space, as well as help China take the lead globally in building space computing infrastructure, seize the commanding heights of this future industry. The development could mark the beginning of space-based cloud computing as a new capability, as well as open a new arena for strategic competition with the U.S. You can watch a recording of the launch here.

Dartmouth researchers propose that dark matter originated from massless, light-like particles in the early universe that rapidly condensed into massive particles through a spin-based interaction. Phys.Org reports: [T]he study authors write that their theory is distinct because it can be tested using existing observational data. The extremely low-energy particles they suggest make up dark matter would have a unique signature on the cosmic microwave background, or CMB, the leftover radiation from the Big Bang that fills all of the universe. "Dark matter started its life as near-massless relativistic particles, almost like light," says Robert Caldwell, a professor of physics and astronomy and the paper's senior author. "That's totally antithetical to what dark matter is thought to be -- it is cold lumps that give galaxies their mass," Caldwell says. "Our theory tries to explain how it went from being light to being lumps."

Hot, fast-moving particles dominated the cosmos after the burst of energy known as the Big Bang that scientists believe triggered the universe's expansion 13.7 billion years ago. These particles were similar to photons, the massless particles that are the basic energy, or quanta, of light. It was in this chaos that extremely large numbers of these particles bonded to each other, according to Caldwell and Guanming Liang, the study's first author and a Dartmouth senior. They theorize that these massless particles were pulled together by the opposing directions of their spin, like the attraction between the north and south poles of magnets. As the particles cooled, Caldwell and Liang say, an imbalance in the particles' spins caused their energy to plummet, like steam rapidly cooling into water. The outcome was the cold, heavy particles that scientists think constitute dark matter. The findings have been published in the journal Physical Review Letters.

Scientists have successfully treated a 9.5-month-old boy with an ultra-rare genetic disorder using the world's first personalized gene-editing therapy. The patient, identified as KJ, has CPS1 deficiency -- a condition affecting just one in 1.3 million babies that prevents proper ammonia processing and is often fatal.

The breakthrough treatment, detailed in the New England Journal of Medicine, uses base editing technology to correct KJ's specific DNA mutation. The therapy delivers CRISPR components wrapped in fatty lipid molecules that protect them in the bloodstream until they reach liver cells, where they make the precise edit needed.

After three infusions, KJ now eats normal amounts of protein and has maintained stable ammonia levels even through viral illnesses that would typically cause dangerous spikes. His weight has increased from the 7th to 40th percentile. Dr. Peter Marks, former FDA official, called the approach "one of the most potentially transformational technologies" because it could be rapidly adapted for thousands of other rare genetic diseases without lengthy development cycles.

Montana has passed a bill allowing licensed clinics to offer experimental medical treatments that haven't been approved by the FDA, provided the drugs have passed phase I safety trials. MIT Technology Review reports: The bill, which was passed by the state legislature on April 29 and is expected to be signed by Governor Greg Gianforte, essentially expands on existing Right to Try legislation in the state. But while that law was originally designed to allow terminally ill people to access experimental drugs, the new bill was drafted and lobbied for by people interested in extending human lifespans -- a group of longevity enthusiasts that includes scientists, libertarians, and influencers. These longevity enthusiasts are hoping Montana will serve as a test bed for opening up access to experimental drugs. [...]

Supporters of the bill say it gives individuals the freedom to make choices about their own bodies. At the same event, bioethicist Jessica Flanigan of the University of Richmond said she was "optimistic" about the measure, because "it's great any time anybody is trying to give people back their medical autonomy." Ultimately, they hope that the new law will enable people to try unproven drugs that might help them live longer, make it easier for Americans to try experimental treatments without having to travel abroad, and potentially turn Montana into a medical tourism hub.

But ethicists and legal scholars aren't as optimistic. "I hate it," bioethicist Alison Bateman-House of New York University says of the bill. She and others are worried about the ethics of promoting and selling unproven treatments -- and the risks of harm should something go wrong. [...] At any rate, the clinics are coming to Montana, says [Dylan Livingston, founder and CEO of the Alliance for Longevity Initiatives]. "We have half a dozen that are interested, and maybe two or three that are definitively going to set up shop out there." He won't name names, but he says some of the interested clinicians already have clinics in the US, while others are abroad."

Mac Davis -- founder and CEO of Minicircle, the company that developed the controversial "anti-aging" gene therapy -- told MIT Technology Review he was "looking into it." "I think this can be an opportunity for America and Montana to really kind of corner the market when it comes to medical tourism," says Livingston. "There is no other place in the world with this sort of regulatory environment."

Longtime Slashdot reader ndsurvivor shares a report from TechCrunch: In 2018, Liangbing Hu, a materials scientist at the University of Maryland, devised a way to turn ordinary wood into a material stronger than steel. It seemed like yet another headline-grabbing discovery that wouldn't make it out of the lab. "All these people came to him," said Alex Lau, CEO of InventWood, "He's like, OK, this is amazing, but I'm a university professor. I don't know quite what to do about it."

Rather than give up, Hu spent the next few years refining the technology, reducing the time it took to make the material from more than a week to a few hours. Soon, it was ready to commercialize, and he licensed the technology to InventWood. Now, the startup's first batches of Superwood will be produced starting this summer. "Right now, coming out of this first-of-a-kind commercial plant -- so it's a smaller plant -- we're focused on skin applications," Lau said. "Eventually we want to get to the bones of the building. Ninety percent of the carbon impact from buildings is concrete and steel in the construction of the building." To build the factory, InventWood has raised $15 million in the first close of a Series A round. The round was led by the Grantham Foundation with participation from Baruch Future Ventures, Builders Vision, and Muus Climate Partners, the company exclusively told TechCrunch. How do they do it? According to TechCrunch, InventWood's Superwood is made by treating regular timber with "food industry" chemicals to remove lignin and modify its structure, then compressing it to increase hydrogen bonding between cellulose fibers. This densification makes the wood up to 10 times stronger than natural wood, with a higher strength-to-weight ratio than steel. "You end up with something that looks like these richer, tropical hardwoods," Lau added.

An anonymous reader quotes a report from the BBC: A student's robot has beaten the world record for solving a four-by-four Rubik's cube -- by 33 seconds. Matthew Pidden, a 22-year-old University of Bristol student, built and trained the "Revenger" over 15 weeks for his computer science bachelor's degree. The robot solved the cube in 45.305 seconds, obliterating the world record of 1 minute 18 seconds. However, the human record for solving the cube is 15.71 seconds.

Mr Pidden's robot uses dual webcams to scan the cube, a custom mechanism to manipulate the faces, and a fully self-built solving algorithm to generate efficient solutions. The student now plans to study for a master's degree in robotics at Imperial College London.

Dutch researchers have recalculated the timeline for cosmic decay via Hawking-like radiation and found that the universe may end much sooner than previously thought -- around 10^78 years, rather than 10^1100. Phys.Org reports: The research by black hole expert Heino Falcke, quantum physicist Michael Wondrak, and mathematician Walter van Suijlekom (all from Radboud University, Nijmegen, the Netherlands) is a follow-up to a 2023 paper by the same trio. In that paper, they showed that not only black holes, but also other objects such as neutron stars, can "evaporate" via a process akin to Hawking radiation. After that publication, the researchers received many questions from inside and outside the scientific community about how long the process would take. They have now answered this question in the new article.

The researchers calculated that the end of the universe is about 10^78 years away, if only Hawking-like radiation is taken into account. This is the time it takes for white dwarf stars, the most persistent celestial bodies, to decay via Hawking-like radiation. Previous studies, which did not take this effect into account, put the lifetime of white dwarfs at 10^1100 years. Lead author Heino Falcke said, "So the ultimate end of the universe comes much sooner than expected, but fortunately it still takes a very long time." The findings have been published in the Journal of Cosmology and Astroparticle Physics.

Evidence is mounting for "a vast reservoir of liquid water" on Mars, according to a new article by Australian National University professor Hrvoje TkalÄiÄ and geophysics associate professor Weijia Sun from the Chinese Academy of Geological Sciences, announcing their recently published paper.

"Using seismic data from NASA's InSight mission, we uncovered evidence that the seismic waves slow down in a layer between 5.4 and 8 kilometres below the surface, which could be because of the presence of liquid water at these depths." Mars is covered in traces of ancient bodies of water. But the puzzle of exactly where it all went when the planet turned cold and dry has long intrigued scientists... Billions of years ago, during the Noachian and Hesperian periods (4.1 billion to 3 billion years ago), rivers carved valleys and lakes shimmered. As Mars' magnetic field faded and its atmosphere thinned, most surface water vanished. Some escaped to space, some froze in polar caps, and some was trapped in minerals, where it remains today. But evaporation, freezing and rocks can't quite account for all the water that must have covered Mars in the distant past.

Calculations suggest the "missing" water is enough to cover the planet in an ocean at least 700 metres deep, and perhaps up to 900 metres deep. One hypothesis has been that the missing water seeped into the crust. Mars was heavily bombarded by meteorites during the Noachian period, which may have formed fractures that channelled water underground. Deep beneath the surface, warmer temperatures would keep the water in a liquid state — unlike the frozen layers nearer the surface.

In 2018, NASA's InSight lander touched down on Mars to listen to the planet's interior with a super-sensitive seismometer. By studying a particular kind of vibration called "shear waves", we found a significant underground anomaly: a layer between 5.4 and 8 kilometres down where these vibrations move more slowly. This "low-velocity layer" is most likely highly porous rock filled with liquid water, like a saturated sponge. Something like Earth's aquifers, where groundwater seeps into rock pores. We calculated the "aquifer layer" on Mars could hold enough water to cover the planet in a global ocean 520-780m deep.
InSight's seismometer captured vibrations between the crust of Mars and its lower layers from two meteorite impacts in 2021 and a Marsquake in 2022. "These signatures let us pinpoint boundaries where rock changes, revealing the water-soaked layer 5.4 to 8 kilometres deep."

It's an exciting possibility. "Purified, it could provide drinking water, oxygen, or fuel for rockets." And since microbes thrives on earth in deep rocks filled with water, "Could similar life, perhaps relics of ancient Martian ecosystems, persist in these reservoirs?"

18 years ago Slashdot covered the creation of Spaceport America.

Today Space.com hails it as "the first purpose-built commercial spaceport in the world." But engineer/executive director Scott McLaughlin has plans to grow even more. Already home to an array of commercial space industry tenants, such as Virgin Galactic, SpinLaunch, Up Aerospace, and Prismatic, Spaceport America is a "rocket-friendly environment of 6,000 square miles of restricted airspace, low population density, a 12,000-foot by 200-foot runway, vertical launch complexes, and about 340 days of sunshine and low humidity," the organization boasts on its website...

Space.com: What changes do you see that make Spaceport America even more viable today?

McLaughlin: I think opening ourselves up to doing different kinds of work. We're more like a civilian test range now. We've got high-altitude UAVs [Unmanned Aerial Vehicles]. We're willing to do engine production. We believe we're about to sign a data center, one that's able to provide services to our customers who want low-latency, artificial intelligence, or high-powered computing. You'll be able to rent some virtual machines and do your own thing and have it be instantaneous at the spaceport. So I think being more broadminded about what we can do at the spaceport is helping generate customers and revenue...

Our goal is to see Virgin Galactic fly in a year or so, hopefully flying twice a week, and that will have a big impact on the spaceport... [W]e're trying to be open-minded as we're partnered with White Sands Missile Range to use that airspace. We're even looking at things like an electromagnetic pulse facility. It's a customer that I can't identify yet... We are working on a "reentry" license too. We recently discussed this with specialists and we think we have a site relatively close to the spaceport that's flat and free of mesquite bushes and such, so we can do capsule return and other types of return. And of course we have the runway. So I'd think we'd be the only spaceport that does vertical and horizontal launch and reentry....

We're never going to have the throughput that the Cape in Florida has. But we'll be a good alternative especially if you're going to do a small to medium-sized launch, and you need to do it quickly, and perhaps do it more securely than you would if you were to fly over water. That's why the Department of Defense is showing interest in the inland spaceport.

"The romantic partner of Theranos fraudster Elizabeth Holmes has launched a start-up that sounds eerily similar to the venture that landed his girlfriend behind bars," writes The Daily Beast.

He's incorporated "Haemanthus" in Delaware a year and a half ago (though the company operates out of his neighborhood in Austin), according to the New York Times. Haemanthus appears to have around 10 employees.

From The Daily Beast: California hotel heir Billy Evans' new company is a blood-testing firm that markets itself as "the future of diagnostics," offering "a radically new approach to health testing," according to The New York Times. In other words, exactly what Theranos said it would do. Holmes is even advising the start-up from the Texas prison where she is serving out an 11-year prison sentence for fraud, sources told NPR... Evans has managed to raise nearly $20 million in funds from both friends and established investors in Austin and San Francisco, according to the investor materials.
The Times reports that Evan's company "plans to begin with testing pets for diseases before progressing to humans, according to two investors pitched on the company."

And TechCrunch reminds readers that Elizabeth Holmes said in a recent interview "that she remains 'completely committed to my dream of making affordable healthcare solutions available to everyone.'"

Elizabeth Holmes has lost her bid to have the appeal of her 2022 fraud conviction reheard by the 9th Circuit Court of Appeals, leaving the U.S. Supreme Court as her final option. She and former Theranos executive Sunny Balwani remain liable for $452 million in restitution, while Holmes continues serving her 11-year sentence. CNBC reports: The 9th Circuit U.S. Court of Appeals denied Holmes' request for a rehearing before the original three-judge panel that upheld her conviction. At the same time, the court said no judge on the circuit court had asked for a vote on whether to have the full court rehear the appeal.

Holmes, 41, was sentenced in January 2023 to 11 years and 3 months in prison after being found guilty of four counts of wire fraud in January 2022. She was found guilty of deceiving investors about the capabilities of Theranos, the blood-testing company she founded in 2003. The company crumbled after a Wall Street Journal story outlined the firm's struggles and shut down in 2018.

sciencehabit shares a repot from Science.org: Scientists have captured fungal spores cruising in the inhospitable environment of the stratosphere, much higher than commercial aircraft fly. When brought back to the lab, the researchers found that some of the spores -- including pathogens of plants and people -- had survived intercontinental trips and could be cultured in the lab. Although spores and microbes have been detected in the stratosphere before, the new results come from a cheap, homespun sampling device dangled from weather balloons, the project could help researchers figure out what traits and conditions allow spores to survive a swing through the stratosphere and how they get up there in the first place. The work could also be a first step towards an atmospheric monitoring system that could nip emerging fungal pathogens in the bud, the study's authors reported at a conference of the European Geophysical Union.

After five preliminary flights, the team has already learned a lot. Based on DNA sequencing analysis, they identified spores from 235 genera, including fungi that infect blackberries and carrots in the United States and Japan, and one species, Naganishia albida, that can make immunocompromised people sick. In the lab, they were able to revive and culture spores from 15 different fungal species, among them several plant pathogens. Mostly, the results show that their sampler works. Now, the researchers want to set up regular flights to track airborne fungal biodiversity and seasonal variations. They also want to identify how events such as wildfires or volcanic eruptions inject spores into the stratosphere.

Researchers have discovered a mutation in the SIK3 gene that enables some people to function normally on just three to six hours of sleep. The finding, published this week in PNAS, adds to a growing list of genetic variants linked to naturally short sleepers.

When University of California, San Francisco scientists introduced the mutation to mice, the animals required 31 minutes less sleep daily. The modified enzyme showed highest activity in brain synapses, suggesting it might support brain homeostasis -- the resetting process thought to occur during sleep.

"These people, all these functions our bodies are doing while we are sleeping, they can just perform at a higher level than we can," said Ying-Hui Fu, the study's co-author. This marks the fifth mutation across four genes identified in naturally short sleepers. Fu's team hopes these discoveries could eventually lead to treatments for sleep disorders by revealing how sleep regulation functions in humans.