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Space

JPL To Cut 5% of Workforce, Its Third Layoff This Year (behindtheblack.com) 42

An anonymous reader writes: JPL in California announced this week a layoff of 325 workers, about 5% of its workforce, the third major layoff imposed this year.

The JPL press release indicates the layoffs are because of NASA budget cutbacks, but does not provide any specificity. The cause centers mostly around NASA's decision to pause its Mars Sample Return project, which JPL was leading. From this report:

This is the third round of layoffs at JPL this year, a reduction spurred primarily by major budgetary cuts to the Mars Sample Return mission, which is managed by JPL. NASA directed $310 million this year to the effort to bring Mars rocks back to Earth, a steep drop from the $822.3 million it spent on the program the previous year.


Science

Missed Deadlines Lead People To Judge Work More Harshly, Study Says (theguardian.com) 91

A new study reveals that late work is judged more negatively than on-time submissions, even if delays are minimal or pre-communicated. "The findings suggest that, while you might be tempted to take the maximum allotted time to put the finishing touches to a report, submission or piece of work, the extra effort might not be appreciated by colleagues if it comes at the expense of punctual delivery," reports The Guardian. From the report: The study surveyed thousands of people in the US and UK, including managers, executives, human resources personnel and others whose jobs included an element of evaluating others. Participants were asked to rate pieces of work, such as advertising flyers, art, business proposals, product pitches, photography and news articles. But first, they were told it was either submitted early, on deadline or late. "Late" work was consistently rated as worse in quality than when people were told the same work was completed early or on time. The difference was equivalent to including an objective shortcoming such as not meeting a word count.

A missed deadline led evaluators to believe an employee had less integrity, and they reported they would be less willing to work with or assign tasks to that person in the future. "Everyone saw the exact same art contest entry, school submission or business proposal, but they couldn't help but use their knowledge of when it came in to guide their evaluation of how good it was," said Maglio, who co-authored the study with David Fang of Stanford University.

Those who eagerly submit work early should be advised that this does not appear to earn a boost in opinion, according to the report in the journal Organizational Behavior and Human Decision Processes. It also didn't matter how late the work was submitted, with one day or one week delays viewed just as negatively -- and that remained the case if the employee gave their manager advance warning. The latest study suggests that it is this inability to plan realistically that is frowned on, with factors beyond an employee's control, such as jury duty, not viewed as negatively. "If the reason why you missed the deadline was beyond your control, you as the employee should let your manager know," said Maglio. "That seems to be one of the few instances in which people cut you a break."

Medicine

Amazon Shuts Down Secret Project To Develop Fertility Tracker 94

Amazon has discontinued its secretive "Encore" project to develop an at-home fertility tracker, resulting in layoffs for around 100 employees. The project, part of Amazon's Grand Challenge division, aimed to launch a device and app that would predict fertility through saliva testing but was ultimately terminated to control costs. CNBC reports: The project was born out of the company's 2020 acquisition of Wisconsin-based startup bluDiagnostics, the sources said. BluDiagnostics was founded in 2015 by Weibel, Katie Brenner and Jodi Schroll, all of whom joined Grand Challenge. The startup had developed a thermometer-like device, called FertilityFinder, to help women track their fertility from home by testing their saliva and measuring two key hormones, estradiol and progesterone. The results of the test were viewable through a corresponding app. Business Insider reported on aspects of the fertility device in 2022, when its codename was Project Tiberius.

The team was working to develop its own saliva collection device and mobile app, which could predict when a user might be in the fertile window. Users could also log their period symptoms, sexual activity and other data to assist with tracking their fertility. There are similar offerings on the market from companies including Inne, Oova, Ava and Mira, along with fertility and ovulation tracking apps such as Flo, Clue and Max Levchin's Glow. Amazon initially aimed to release the product this year, but the timing was pushed out after the team encountered technical issues with the device, one of the people said. It was a costly endeavor and required significant upfront investments for lab research and development, in addition to the high salaries for scientists and engineers, the sources said, adding that the team's weekly overhead was roughly $1.5 million. Amazon didn't comment on the figure. Only one project now remains active within Grand Challenge. Its focus is on health tech, the people said.
"We regularly review our businesses to ensure we focus on areas where we can make the biggest difference for customers," said Amazon spokesperson Margaret Callahan. "Following a recent review, we've decided to discontinue this project within Grand Challenge, and we're working directly with employees whose roles are impacted to support them through the transition and help them find other opportunities within Amazon."
AI

AI Systems Solve Just 2% of Advanced Maths Problems in New Benchmark Test 80

Leading AI systems are solving less than 2% of problems in a new advanced mathematics benchmark, revealing significant limitations in their reasoning capabilities, research group Epoch AI reported this week.

The benchmark, called FrontierMath, consists of hundreds of original research-level mathematics problems developed in collaboration with over 60 mathematicians, including Fields Medalists Terence Tao and Timothy Gowers. While top AI models like GPT-4 and Gemini 1.5 Pro achieve over 90% accuracy on traditional math tests, they struggle with FrontierMath's problems, which span computational number theory to algebraic geometry and require complex reasoning.

"These are extremely challenging. [...] The only way to solve them is by a combination of a semi-expert like a graduate student in a related field, maybe paired with some combination of a modern AI and lots of other algebra packages," Tao said. The problems are designed to be "guessproof," with large numerical answers or complex mathematical objects as solutions, making it nearly impossible to solve without proper mathematical reasoning.

Further reading: New secret math benchmark stumps AI models and PhDs alike.
Science

Cheap Fix Floated For Plane Vapor's Climate Damage (bbc.co.uk) 54

AmiMoJo writes: The climate-damaging vapors left behind by jet planes could be easily tackled, aviation experts say, with a new study suggesting they could be eliminated for a few pounds per flight. Jet condensation trails, or contrails, have spawned wild conspiracy theories alleging mind control and the spreading of disease, but scientists say the real problem is their warming effect.

"They create an artificial layer of clouds, which traps the heat from the Earth that's trying to escape to outer space," said Carlos Lopez de la Osa, from the Transport & Environment campaign group, which has carried out a new study on the solutions to contrails. "The scale of the warming that's associated with them is roughly having a similar impact to that of aviation carbon emissions."

Tweaking the flight paths of a handful of aircraft could reduce contrail warming by more than half by 2040, at a cost of less than $5.1 per flight. Geography and a flight's latitude have a strong influence on whether a contrail is warming. Time of day also influences the climate effects of contrails. Those formed by evening and night flights have the largest warming contribution. Seasonality is also important -- the most warming contrails tend to occur in winter. "Planes are already flying around thunderstorms and turbulence areas," Mr Lopez de la Osa said. "We will need to add one more constraint to flight planning, which is avoiding areas of contrail formation."

Space

New Study On Moons of Uranus Raises Chance of Life 37

A new analysis of data from NASA's Voyager 2 mission reveals that the planet Uranus and its five largest moons might harbor subsurface oceans and potential conditions for life. The BBC reports: Much of what we know about them was gathered by Nasa's Voyager 2 spacecraft which visited nearly 40 years ago. But a new analysis shows that Voyager's visit coincided with a powerful solar storm, which led to a misleading idea of what the Uranian system is really like. [...] So, for 40 years we have had an incorrect view of what Uranus and its five largest moons are normally like, according to Dr William Dunn of University College London. "These results suggest that the Uranian system could be much more exciting than previously thought. There could be moons there that could have the conditions that are necessary for life, they might have oceans below the surface that could be teeming with fish!".

It has been nearly 40 years since Voyager 2 last flew past the icy world and its moons. Nasa has plans to launch a new mission, the Uranus Orbiter and Probe, to go back for a closer look in 10 years' time. According to Nasa's Dr Jamie Jasinski, whose idea it was to re-examine the Voyager 2 data, the mission will need to take his results into account when designing its instruments and planning the scientific survey. "Some of the instruments for the future spacecraft are very much being designed with ideas from what we learned from Voyager 2 when it flew past the system when it was experiencing an abnormal event. So we need to rethink how exactly we are going to design the instruments on the new mission so that we can best capture the science we need to make discoveries." Nasa's Uranus probe is expected to arrive by 2045, which is when scientists hope to find out whether these far-flung icy moons, once thought of as being dead worlds, might have the possibility of being home to life.
The findings have been published in the journal Nature Astronomy.
Biotech

23andMe To Lay Off 40% of Its Workforce, Discontinue All Therapy Programs (bbc.com) 72

The genetic testing company 23andMe announced it will cut 40% of its workforce, or 200 jobs, and halt the work on therapies it was developing. As the BBC notes, the company is fighting for survival after hackers gained access to personal information of millions of its users, causing the stock to crater by more than 70%. All seven of its independent directors also resigned in September, following a protracted negotiation with founder and Chief Executive Anne Wojcicki over her plan to take the company private. The BBC reports: On Tuesday, the company warned investors of "substantial doubt" about its ability to continue operating, as it reported that revenue had fallen to $44 million between July and September compared to $50 million in the same period last year. Losses fell to $59 million from $75 million. The job cuts are expected to lead to one-off costs of $12 million, including severance pay, for the plan that will result in savings of $35 million. "We are taking these difficult but necessary actions as we restructure 23andMe and focus on the long-term success of our core consumer business and research partnerships," Ms Wojcicki said.

The company also said it is considering what to do with the therapies it had in development, including licensing or selling them. 23andMe is a giant of the growing ancestor-tracing industry. It offers genetic testing from DNA, with ancestry breakdown and personalised health insights. Its customers include famous names, from rapper Snoop Dogg to multi-billionaire investor Warren Buffett. The company was valued at roughly $3.5 billion when it listed on the Nasdaq stock exchange in 2021 and its share price peaked at $17.65. But they have since tumbled and are currently trading at less than $5.

Space

SpaceX To Attempt Daring Orbital Refueling Test of Starship (gizmodo.com) 98

SpaceX plans an ambitious in-orbit refueling test between two Starships in March 2025. "The orbital demonstration is a major step for Starship, and a crucial part of SpaceX's capability of delivering NASA's Artemis mission to the Moon," reports Gizmodo. The plans were unveiled during Spaceflight Now's recent interview (source: YouTube) with Kent Chojnacki, the deputy manager for NASA's Human Landing System program. Gizmodo reports: SpaceX is under a $53.2 million contract with NASA, signed in 2020, to use Starship tankers for in-orbit propellant transfer. During its third test flight, SpaceX transferred around 10 metric tons of liquid oxygen from Starship's header tank to its main tank while it was in space. The upcoming demonstration, however, requires a lot more of the launch vehicle. Two Starships will launch to low Earth orbit around three to four weeks apart, the spacecraft will meet and dock in orbit, and one will transfer propellant to another. After the demonstration, the two Starships will undock from one another and deorbit.

"Once you've done that, you've really cracked open the opportunity to move massive amounts of payload and cargo outside of the Earth's sphere," Chojnacki said during the interview. The in-flight propellant transfer tests are set to conclude in the summer. With in-flight refueling, NASA is aiming to develop technologies to "enable long-term cryogenic fluid management, which is essential for establishing a sustainable presence on the Moon and enabling crewed missions to Mars," the space agency stated when the contract was signed.

SpaceX is developing a version of Starship to land humans on the Moon in September 2026 as part of NASA's Artemis 3 mission. To prepare for the Moon mission, SpaceX is expected to launch between eight and 16 propellant tanker Starships into low Earth orbit in rapid succession. Each of the tankers will carry around 100 to 150 tons of liquid oxygen and liquid methane and will dock with a larger fuel depot. The orbiting depot will then connect with the Human Landing System Starship, filling its massive 1,200-ton fuel tanks. Once refueled, the Starship lander will continue its journey toward the Moon.

Earth

SpaceX Alums Find Traction On Earth With Their Mars-Inspired CO2-To-Fuel Tech (techcrunch.com) 49

An anonymous reader quotes a report from TechCrunch: A trend has emerged among a small group of climate tech founders who start with their eyes fixed on space and soon realize their technology would do a lot more good here on Earth. Halen Mattison and Luke Neise fit the bill. Mattison spent time at SpaceX, while Neise worked at Vanderbilt Aerospace Design Laboratory and Varda Space Industries. The pair originally wanted to sell reactors to SpaceX that could turn carbon dioxide into methane for use on Mars. Today, they're building them to replace natural gas that's pumped from underground. Their company, General Galactic, which emerged from stealth in April, has built a pilot system that can produce 2,000 liters of methane per day. Neise, General Galactic's CTO, told TechCrunch that he expects that figure to rise as the company replaces off-the-shelf components with versions designed in-house.

"We think that's a big missing piece in the energy mix right now," said Mattison, the startup's CEO. "Being able to own our supply chains, to be able to fully control all of the parameters, to challenge the requirements between components, all of that unlocks some real elegance in the engineering solution." At commercial scale, the company's reactors will be assembled using mass production techniques. It's a contrast to how most petrochemical and energy facilities are built today. General Galactic is focused on producing methane. However, Mattison said the company isn't necessarily looking to displace the fuel from heating and energy. "Those are generally going toward electrification," he said. Instead, it intends to sell its methane to companies that use it as an ingredient or to power a process, like in chemical or plastic manufacturing. The company isn't ruling out transportation entirely either. Mattison hinted that General Galactic is working on other hydrocarbons that could be used for transportation, like jet fuel. "Stay tuned," he said.
General Galactic plans to deploy its first modules next year. The startup "hopes its modules will be able to plug into existing infrastructure, speeding its adoption relative to other fuels like hydrogen," notes TechCrunch.
Science

Self-Experimenting Virologist Defeats Breast Cancer With Lab-Grown Virus Treatment (nature.com) 84

A University of Zagreb virologist treated her own recurring breast cancer by injecting laboratory-grown viruses into her tumor, sparking debate about self-experimentation in medical research. Beata Halassy discovered her stage 3 breast cancer in 2020 at age 49, recurring at the site of a previous mastectomy. Rather than undergo another round of chemotherapy, she developed an experimental treatment using oncolytic virotherapy (OVT).

Over two months, Halassy administered measles and vesicular stomatitis viruses directly into the tumor. The treatment caused the tumor to shrink and detach from surrounding tissue before surgical removal. Post-surgery analysis showed immune cell infiltration, suggesting the viruses had triggered an immune response against the cancer. Halassy has been cancer-free for four years. OVT remains unapproved for breast cancer treatment worldwide. Nature adds: Halassy felt a responsibility to publish her findings. But she received more than a dozen rejections from journals -- mainly, she says, because the paper, co-authored with colleagues, involved self-experimentation. "The major concern was always ethical issues," says Halassy. She was particularly determined to persevere after she came across a review highlighting the value of self-experimentation.

That journals had concerns doesn't surprise Jacob Sherkow, a law and medicine researcher at the University of Illinois Urbana-Champaign who has examined the ethics of researcher self-experimentation in relation to COVID-19 vaccines. The problem is not that Halassy used self-experimentation as such, but that publishing her results could encourage others to reject conventional treatment and try something similar, says Sherkow. People with cancer can be particularly susceptible to trying unproven treatments. Yet, he notes, it's also important to ensure that the knowledge that comes from self-experimentation isn't lost. The paper emphasizes that self-medicating with cancer-fighting viruses "should not be the first approach" in the case of a cancer diagnosis.

Earth

How Gophers Restored Plant Life to a Volcano-Ravaged Mountain - in One Day. (phys.org) 55

When a volcano erupted in 1980 about 70 miles from Portland, "lava incinerated anything living for miles around," remembers an announcement from the University of California at Riverside. But "As an experiment, scientists later dropped gophers onto parts of the scorched mountain for only 24 hours.

"The benefits from that single day were undeniable — and still visible 40 years later." Once the blistering blast of ash and debris cooled, scientists theorized that, by digging up beneficial bacteria and fungi, gophers might be able to help regenerate lost plant and animal life on the mountain. Two years after the eruption, they tested this theory. "They're often considered pests, but we thought they would take old soil, move it to the surface, and that would be where recovery would occur," said UC Riverside microbiologist Michael Allen.

They were right. But the scientists did not expect the benefits of this experiment would still be visible in the soil today, in 2024. A paper out this week in the journal Frontiers in Microbiomes details an enduring change in the communities of fungi and bacteria where gophers had been, versus nearby land where they were never introduced. "In the 1980s, we were just testing the short-term reaction," said Allen. "Who would have predicted you could toss a gopher in for a day and see a residual effect 40 years later?"

In 1983, Allen and Utah State University's James McMahon helicoptered to an area where the lava had turned the land into collapsing slabs of porous pumice. At that time, there were only about a dozen plants that had learned to live on these slabs. A few seeds had been dropped by birds, but the resulting seedlings struggled. After scientists dropped a few local gophers on two pumice plots for a day, the land exploded again with new life. Six years post-experiment, there were 40,000 plants thriving on the gopher plots. The untouched land remained mostly barren.
All this was possible because of what isn't always visible to the naked eye. Mycorrhizal fungi penetrate into plant root cells to exchange nutrients and resources. They can help protect plants from pathogens in the soil, and critically, by providing nutrients in barren places, they help plants establish themselves and survive.

Mycorrhizal fungi also helped an old-growth forest survive, accoridng to the researchers — even after volcano ash had caused them to drop their needles...
Science

This Elephant Learned To Use a Hose As a Shower. Then Her Rival Sought Revenge (science.org) 35

Slashdot reader sciencehabit shared this report from Science magazine: Elephants love showering to cool off, and most do so by sucking water into their trunks and spitting it over their bodies. But an elderly pachyderm named Mary has perfected the technique by using a hose as a showerhead, much in the way humans do. The behavior is a remarkable example of sophisticated tool use in the animal kingdom. But the story doesn't end there.

Mary's long, luxurious baths have drawn so much attention that an envious elephant at the Berlin Zoo has figured out how to shut the water off on her supersoaking rival—a type of sabotage rarely seen among animals.

Both behaviors, reported today in Current Biology, further cement elephants as complex thinkers, says Lucy Bates, a behavioral ecologist at the University of Portsmouth not involved in the study. The work, she says, 'suggests problem solving or even 'insight.''

NASA

NASA Investigates Laser-Beam Welding in a Vacuum for In-Space Manufacturing (nasa.gov) 41

NASA hopes to stimulate in-space manufacturing through a multi-year "laser beam welding collaboration" with Ohio State University. The project "seeks to understand the physical processes of welding on the lunar surface," according to NASA.gov, "such as investigating the effects of laser beam welding in a combined vacuum and reduced gravity environment." The goal is to increase the capabilities of manufacturing in space to potentially assemble large structures or make repairs on the Moon, which will inform humanity's next giant leap of sending astronauts to Mars and beyond. "For a long time, we've used fasteners, rivets, or other mechanical means to keep structures that we assemble together in space," said Andrew O'Connor, a Marshall materials scientist who is helping coordinate the collaborative effort and is NASA's technical lead for the project. "But we're starting to realize that if we really want strong joints and if we want structures to stay together when assembled on the lunar surface, we may need in-space welding."

The ability to weld structures in space would also eliminate the need to transport rivets and other materials, reducing payloads for space travel. That means learning how welds will perform in space. To turn the effort into reality, researchers are gathering data on welding under simulated space conditions, such as temperature and heat transfer in a vacuum; the size and shape of the molten area under a laser beam; how the weld cross-section looks after it solidifies; and how mechanical properties change for welds performed in environmental conditions mimicking the lunar surface. "Once you leave Earth, it becomes more difficult to test how the weld performs, so we are leveraging both experiments and computer modeling to predict welding in space while we're still on the ground," said O'Connor.

In August 2024, a joint team from Ohio State's Welding Engineering and Multidisciplinary Capstone Programs and Marshall's Materials & Processes Laboratory performed high-powered fiber laser beam welding aboard a commercial aircraft that simulated reduced gravity. The aircraft performed parabolic flight maneuvers that began in level flight, pulled up to add 8,000 feet in altitude, and pushed over at the top of a parabolic arc, resulting in approximately 20 seconds of reduced gravity to the passengers and experiments. While floating in this weightless environment, team members performed laser welding experiments in a simulated environment similar to that of both low Earth orbit and lunar gravity. Analysis of data collected by a network of sensors during the tests will help researchers understand the effects of space environments on the welding process and welded material.

They performed that laser-beam welding in a vacuum chamber during the parabolic flight (on a Boeing 727), according to the article — and successfully completed 69 out of 70 welds in microgravity and lunar gravity conditions. "The last time NASA performed welding in space was during the Skylab mission in 1973...

"Practical welding and joining methods and allied processes, including additive manufacturing, will be required to develop the in-space economy."
NASA

Is There New Evidence for a 9th Planet - Planet X? (discovermagazine.com) 145

This week Discover magazine looks at evidence — both old and new — for a ninth planet in our solar system: "Orbits of the most distant small bodies — comets or asteroids — seem to be clustered on one half or one side of the solar system," says Amir Siraj [an astrophysicist with Princeton University]. "That's very weird and something that can't be explained by our current understanding of the solar system." A 2014 study in Nature first noted these orbits. A 2021 study in The Astronomical Journal examined the clustering in the orbit and concluded that "Planet Nine" was likely closer and brighter than expected.

Astrophysicists don't agree whether the clustering in the orbit is a real effect. Some have argued it is biased because the view that scientists currently have is limited, Siraj says. "This debate for the last decade has a lot of scientists confused, including myself. I decided to look at the problem from scratch," he says.

In a 2024 paper, Siraj and his co-authors ran simulations of the solar system, including an extra planet beyond Neptune. "We did it 300 times, about 2.5 times more than what was done previously," Siraj says. "In each simulation, you try different parameters for the extra planet. A different mass, a different tilt, a different shape of the orbit. You run these for millions of years, and then you compare the distribution to what we see in our solar system...." They found that the perimeters for this possible planet were different than what has been previously discussed in the scientific literature, and they supported the possibility of an unseen planet beyond Neptune.

Scientists hope a new telescope will have the potential to see deeper into the solar system. In 2025, the Vera C. Rubin Observatory on Cerro Pachón — a mountain in Chile, is expected to go online. The observatory boasts that in the time it takes a person to open up their phone and pose for a selfie, their new telescope will be able to snap an image of 100,000 galaxies, many of which have never been seen by scientists. The telescope will have the largest digital camera ever built, the LSST. Siraj says he expects it will take "the deepest, all-sky survey that humanity has ever conducted." So, what might the Rubin Observatory find past Neptune? Based on the current literature, Siraj sees a few possibilities. One is that the Rubin Observatory, with its increased capabilities, might be able to see a planet beyond Neptune... "Next year is going to be an enormous year for solar system science," he says.

NASA points out that the Hawaii-based Keck and Subaru telescopes are also searching for Planet X, while "a NASA-funded citizen science project called Backyard Worlds: Planet 9, encourages the public to help search using images captured by NASA's Wide-field Infrared Survey Explorer (WISE) mission.

And starting next year the Rubin observatory will also "search for more Kuiper Belt objects. If the orbits of these objects are systematically aligned with each other, it may give more evidence for the existence of Planet X (Planet Nine), or at least help astronomers know where to search for it.

"Another possibility is that Planet X (Planet Nine) does not exist at all. Some researchers suggest the unusual orbit of those Kuiper Belt objects can be explained by their random distribution."

Thanks to long-time Slashdot reader Tablizer for sharing the news.
Medicine

How the Majority of Strokes Could Be Prevented (apnews.com) 61

"The majority of strokes could be prevented," reports the Associated Press, according to the first new guidelines in 10 years from the American Stroke Association, which are "aimed at helping people and their doctors do just that." Stroke was the fourth leading cause of death in the U.S. in 2023, according to the Centers for Disease Control and Prevention, and more than half a million Americans have a stroke every year. But up to 80% of strokes may be preventable with better nutrition, exercise and identification of risk factors... The good news is that the best way to reduce your risk for stroke is also the best way to reduce your risk for a whole host of health problems — eat a healthy diet, move your body and don't smoke...

Eating healthy can help control several factors that increase your risk for stroke, including high cholesterol, high blood sugar, and obesity, according to the heart association. The group recommends foods in the so-called Mediterranean diet such as fruits, vegetables, whole grains and olive oil, which can help keep cholesterol levels down. It suggests limiting red meat and other sources of saturated fat. Instead, get your protein from beans, nuts, poultry, fish and seafood. Limit highly processed foods and foods and drinks with a lot of added sugar. This can also reduce your calorie intake, which helps keep weight in check.

Getting up and walking around for at least 10 minutes a day can "drastically" reduce your risk, said Dr. Cheryl Bushnell, a neurologist at Wake Forest University School of Medicine who was part of the group that came up with the new guidelines. Among the many benefits: Regular exercise can help reduce blood pressure, a major risk factor for stroke. Of course, more is better: The heart association recommends at least 150 minutes of moderate aerobic or 75 minutes of vigorous activity — or some combination — per week. How you do it doesn't matter so much, experts said: Go to the gym, take a walk or run in your neighborhood or use treadmills or stepper machines at home. Diet and exercise can help control weight, another important risk factor for strokes.

But in addition, the guidelines now recommend that doctors consider new weight-loss drugs like Ozempic, Wegovy, Mounjaro and Zepbound for people with obesity or diabetes. (Though "people still need to eat well and get exercise, cautions Dr. Fadi Nahab, a stroke expert at Emory University Hospital.")
United States

Forty-Three Monkeys Escape From US Research Lab (bbc.com) 138

An anonymous reader quotes a report from the BBC: Police are on the hunt for 43 monkeys who escaped from a research facility in South Carolina, after a keeper left their pen open. The rhesus macaque fugitives broke out of Alpha Genesis, a company that breeds primates for medical testing and research, and are on the loose in a part of the state known as the Lowcountry. Authorities have urged residents to keep their doors and windows securely closed and to report any sightings immediately. The escaped monkeys are young females, weighing about 7lbs (3.2kg) each, according to the Yemassee Police Department. Police said on Thursday that the company had located the "skittish" group, and "are working to entice them with food."

"Please do not attempt to approach these animals under any circumstances," police said. The statement added that traps had been set in the area, and police were on-site "utilizing thermal-imaging cameras in an attempt to locate the animals". Police say the research company has told them that because of their size, the monkeys have not yet been tested on and "are too young to carry disease."
In an update Friday, the local police department said the monkeys are still staying around the perimeter of the facility. "The primates are exhibiting calm and playful behavior, which is a positive indication," the department noted.

"They're just being goofy monkeys jumping back and forth playing with each other," Alpha Genesis CEO Greg Westergaard told CBS News Thursday. "It's kind of like a playground situation here."

The article points out that all the escaped monkeys "carry no contagious viruses because they were too young to test, according to the lab. "
Space

Nearly Three Years Since Launch, Webb Is a Hit Among Astronomers (arstechnica.com) 30

The James Webb Space Telescope has made groundbreaking discoveries, detecting the most distant galaxy yet and capturing an image of the closest directly-imaged exoplanet. "Judging by astronomers' interest in using Webb, there are many more to come," writes Ars Technica's Stephen Clark. With immense demand for observation time, Webb is set to explore a vast array of cosmic targets -- from early galaxies to exoplanet atmospheres -- offering insights that extend far beyond Hubble's reach. From the report: The Space Telescope Science Institute, which operates Webb on behalf of NASA and its international partners, said last week that it received 2,377 unique proposals from science teams seeking observing time on the observatory. The institute released a call for proposals earlier this year for the so-called "Cycle 4" series of observations with Webb. This volume of proposals represents around 78,000 hours of observing time with Webb, nine times more than the telescope's available capacity for scientific observations in this cycle. The previous observing cycle had a similar "oversubscription rate" but had less overall observing time available to the science community.

More than 600 scientists will review the proposals and select the most promising ones for time on Webb. The largest share of proposals would involve observing "high-redshift" galaxies among the first generation of galaxies that formed after the Big Bang. Galaxies this old and distant have their light stretched to longer wavelengths due to the expansion of the Universe. Research involving exoplanet atmospheres and stars and stellar populations were the second- and third-most popular science categories in this cycle. [...] It seems astronomers have no shortage of ideas about where to look. Maybe one day, new super heavy-lift rockets or advancements in in-space assembly will make it possible to deploy space telescopes even more sensitive than Webb. Until then, we can be thankful that Webb is performing well and has a good shot of far outliving its original five-year design life. Let's continue enjoying the show.

Space

World's First Wood-Paneled Satellite Launched Into Space (bbc.com) 47

SpaceX has launched the world's first wood-paneled satellite into space "to test the suitability of timber as a renewable building material in future exploration of destinations like the Moon and Mars," reports the BBC. From the report: Made by researchers in Japan, the tiny satellite weighing just 900g is heading for the International Space Station on a SpaceX mission. It will then be released into orbit above the Earth. Named LignoSat, after the Latin word for wood, its panels have been built from a type of magnolia tree, using a traditional technique without screws or glue. Researchers at Kyoto University who developed it hope it may be possible in the future to replace some metals used in space exploration with wood.

"Wood is more durable in space than on Earth because there's no water or oxygen that would rot or inflame it," Kyoto University forest science professor Koji Murata told Reuters news agency. "Early 1900s airplanes were made of wood," Prof Murata said. "A wooden satellite should be feasible, too." If trees could one day be planted on the Moon or Mars, wood might also provide material for colonies in space in the future, the researchers hope. Along with its wood panels, LignoSat also incorporates traditional aluminium structures and electronic components. It has sensors on board to monitor how its wood reacts to the extreme environment of space during the six months it will orbit the Earth.
You can watch the launch on YouTube.
Space

Researchers Spot Black Hole Eating Stuff At Over 40x the Theoretical Limit (sciencealert.com) 179

Astronomers have discovered a supermassive black hole in the early Universe devouring matter at over 40 times the Eddington limit. ScienceAlert reports: Led by astronomer Hyewon Suh of Gemini Observatory and NSF's NOIRLab, a team of researchers used JWST to take follow-up observations of a smattering of galaxies identified by the Chandra X-ray Observatory that were bright in X-rays but dim in other wavelengths. When they got to LID-568, they were having trouble identifying its distance across space-time. The galaxy was very faint and very hard to see; but, using the integral field spectrograph on JWST's NIRSpec instrument, the team homed in on the galaxy's exact position. LID-568's far-off location is surprising. Although the object is faint from our position in the Universe, its distance means it must be incredibly intrinsically bright. Detailed observations revealed powerful outflows from the supermassive black hole, a signature of accretion as some of the material is being diverted and blasted into space.

A painstaking analysis of the data revealed that the supermassive black hole is a relatively small one, as supermassive black holes go; just 7.2 million times the mass of the Sun. And the amount of light being produced by the material around the disk was much, much higher than a black hole of this mass should be capable of producing. It suggests an accretion rate some 40 times higher than the Eddington limit. At this rate, the period of super-Eddington accretion should be extremely brief, which means Suh and her team were extremely lucky to catch it in action. And we expect that LID-568 will become a popular observation target for black hole scientists, allowing us a rare glimpse into super-Eddington processes.
The research has been published in Nature Astronomy.
The Courts

'The Law Must Respond When Science Changes' (scientificamerican.com) 189

The clash between law's need for finality and science's evolving nature is creating serious justice problems, an opinion piece on Scientific American argued on Monday. Two recent cases highlight this: Robert Roberson faces execution based on now-discredited shaken baby syndrome science, while the Menendez brothers' life sentences are being questioned due to improved understanding of childhood trauma's effects on violence.

Scientific understanding in criminal justice has repeatedly proven wrong. Texas executed Cameron Todd Willingham in 2004 based on invalidated arson science. The FBI found errors in 90% of their reviewed hair analysis cases. Courts still accept bite mark evidence despite experts failing to distinguish human from animal bites. The legal system fails in two critical ways, the story argues: Judges don't properly screen out bad science despite their "gatekeeper" role established in Daubert v. Merrell Dow, and courts resist reopening cases when scientific understanding changes.

While some states like Texas and California have laws allowing appeals based on updated science, implementation remains weak. Roberson has spent 20 years on death row and the Menendez brothers 28 years in prison while courts drag their feet on reviewing their cases with current scientific knowledge. The piece argues that constitutional due process requires allowing convicts to challenge their cases when the science underlying their convictions proves faulty. The system can reform by enforcing stricter scientific evidence standards and creating clear paths to challenge convictions based on outdated science.

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