Single Dose of Magic Mushroom Psychedelic Can Cause Anatomical Brain Changes 28
A small study found that a single 25mg dose of psilocybin produced measurable brain changes that were still visible a month later, along with reported improvements in psychological insight, wellbeing, and mental flexibility. The Guardian reports: Evidence for the changes came from specialized scans that measured the diffusion of water along nerve bundles in the brain. They suggested that some nerve tracts had become denser and more robust after the drug was taken. While the findings are preliminary, the scientists said the opposite was seen in ageing and dementia. "It's remarkable to see potential anatomical brain changes one month after a single dose of any drug," said Prof Robin Carhart-Harris, a neurologist at the University of California, San Francisco, and senior author on the study. "We don't yet know what these changes mean, but we do note that overall, people showed positive psychological changes in this study, including improved wellbeing and mental flexibility."
[...] Writing in Nature Communications, the researchers describe another key finding. Those who had the largest spike in brain entropy after psilocybin were most likely to report deeper psychological insight and better wellbeing a month later, underlining the link between flexible thinking and improved mental health. "It suggests a psychobiological therapeutic action for psilocybin," said Carhart-Harris. Prof Alex Kwan, a neuroscientist at Cornell University in New York, said studies in mice had shown that psychedelics can rewire connections between nerves, a form of "plasticity" that could underlie their therapeutic effects. The big question is whether the same occurs in humans. "This study comes closer than most to addressing that question, by giving evidence of lasting changes in brain structure after psychedelic use," he said. But while the results were "exciting," the study involved a small number of people and DTI provides an indirect and limited view of brain connections, he said.
[...] Writing in Nature Communications, the researchers describe another key finding. Those who had the largest spike in brain entropy after psilocybin were most likely to report deeper psychological insight and better wellbeing a month later, underlining the link between flexible thinking and improved mental health. "It suggests a psychobiological therapeutic action for psilocybin," said Carhart-Harris. Prof Alex Kwan, a neuroscientist at Cornell University in New York, said studies in mice had shown that psychedelics can rewire connections between nerves, a form of "plasticity" that could underlie their therapeutic effects. The big question is whether the same occurs in humans. "This study comes closer than most to addressing that question, by giving evidence of lasting changes in brain structure after psychedelic use," he said. But while the results were "exciting," the study involved a small number of people and DTI provides an indirect and limited view of brain connections, he said.
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Re: scares me too much ill never do that (Score:1)
Isn't it quite uncommon that substances are forced into people? There's a whole debate about the vaccines but I am not aware of anyone being forced to be vaccinated. It's just that some doors close if you don't get vaccinated. This might change from one country/state to another. Is it common in psychotherapy that people are forced to take substances?
The lab-rat audience. (Score:2)
Isn't it quite uncommon that substances are forced into people?
Cigarettes used to be given to patents by sponsored doctors. Back when your roofing materials were still made out of asbestos. Butter wasn’t quite deadly enough, so we stole a molecule from plastic and invented margarine as the “better” alternative. For Big Pharmas sake. Then the Medical Industrial Complex caught on and went full HAM; HFCS replaced sugar. Preservatives and numbered dyes replaced natural ingredients. “Organic” became a legal term. “Healthy” bo
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Psychotherapy is unusual in that regard and they have a long history of doing exactly that. Particularly in the US. A very large chunk of what is known about psychoactive drugs come from American government programs where patients were injected without consent with a range of substances. A lot of their biological warfare research in the 60s and 70s, possibly into the 80s, was also done that way, allowing patients to die slowly from a range of diseases.
Nor has this completely stopped. The Gitmo "enhanced int
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Why would we do that? When it comes to large scale deployment of mind-altering drugs, chemtrails are so much easier. Did you think you came to the conclusion that the earth is flat and vaccines are bad all on your own? You wish. You will believe whatever suits us. Nothing more, nothing less.
Re: scares me too much ill never do that (Score:5, Interesting)
I believe that in the US, under current law anyway, "forcing" such medication on a patient would be illegal, malpractice, and anathema to any normal practitioner.
I'll admit that there are corner cases where some patients are forcibly medicated (I know of none where psilocybin is used), but simple walking-around-really-depressed isn't going to rise to a forced medication scenario.
I'll offer a couple more thoughts:
1. If it's the 'tripping' part that scares you, they're working on subcomponents of the drug that provide little to none of the psychedelic experience. No idea where the work on this currently stands.
2. An anecdote, not data: from my couple experiences with psilocybin decades ago, my trips rank among the best and peak experiences of my life. Not "dude, I'm so messed up" but instead, open to all the best things in my life, aware of the potential in my hands to shape my life for good, more confidence in myself than I'd ever felt.
Uniformly good, and I feel it still benefits me. I got a peek behind the corner of the scenery of life, and better understand what's 'really' going on; what obstacles I'm capable of putting in my own way.
Not everyone's experience is good, nor so good, but in an assisted, therapeutic setting, I can see how this can help people.
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I'm leery of professional practice as there has been numerous document cases of abuse by both practitioners and government. Can't say if that aspect has ended or is just more well hidden. I doubt the quest for a mind control drug has gone away.
That said, the benefits of psilocybin are well documented. I just don't trust the current regulatory environment.
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Please remember the APA voted to torture and destroy the minds of people who wore Casio watches, and assisted in that torture program. (All anyone needed to be arrested under the bounty program was to be in a suspicious area or to have a highly accurate clock or watch. No actual evidence of wrongdoing was required.)
Many practitioners had absolutely no problems with abusing their knowledge and ability, not against actual terrorists or even people from the same nation as the terrorists, but against easy targe
Re: scares me too much ill never do that (Score:2)
Yeah, when I wrote "any normal practitioner", I was thinking of MK-ULTRA (as abnormal), but a CIA/DOD torturer/interrogator would fit the abnormal mold, too.
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I believe that in the US, under current law anyway, "forcing" such medication on a patient would be illegal, malpractice, and anathema to any normal practitioner.
That explains why Gavin Newsom wants to do it to the homeless.
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I'll second this â" I did mushrooms once many years ago, and it ranks as one of the most intense euphoric experiences I have ever had. It was truly life-changing.
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anathema
How long have you been waiting to squeeze that into a conversation?
Re: scares me too much ill never do that (Score:3)
One more thought:
Your thoughts and emotions also get changed and rewired by:
Reading books
Seeing lectures
Talking to people
Practicing an instrument
Doing math
Falling in love
Having and/or caring for a kid
And a whole bunch more.
Hope you're not willing to give all that up out of fear.
Re: scares me too much ill never do that (Score:5, Interesting)
The way you describe it isn't really how it works. It doesn't rewire your brain in an active sense so much as introduce elasticity for your brain to rewire itself. This is especially useful when the brain has gotten itself into a doom loop of depression or anxiety. The psilocybin allows you to break out of the doom loop and start your brain on the path of healthy development.
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The way you describe it isn't really how it works. It doesn't rewire your brain in an active sense so much as introduce elasticity for your brain to rewire itself. This is especially useful when the brain has gotten itself into a doom loop of depression or anxiety. The psilocybin allows you to break out of the doom loop and start your brain on the path of healthy development.
That sounds great. However, anything that causes anatomical brain chages that persist after a month, with a single dose, would be, by me, considered unacceptably risky. I'm not saying that it's by default considered bad, both you and the paper are talking about positive changes, and that's good. I'm saying, "risky," as in, I don't know what negative effects haven't been identified and I'd need a much more complete understanding before I'd be willing to try it.
Most of the positive effects are in reported wel
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If you want to be an angry delusional person, you can still be one even with psychedelics.
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Re: scares me too much ill never do that (Score:2)
It is funny that you mention that book, as the author disavowed it after taking psychedelics changed his perspective.
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I want to be a person who can manage their own psychological well being unaided.
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i fear this will eventually be forced on people who dont want it; who would rather get thru their problems themselves; rather than having their brain rewired and possibly personality changes no way i dont care how bad off i get i dont want anything changing who i am; how i see the world; or how i process my emotions
Years ago I lost quite a bit of money with a so-called meme stock Mind Med. Their idea was that psilocybin could be an important part of therapy, but not to be provided separately from talk-therapy. It was never meant to be over the counter medicine.
As for changing the way you are... trauma does that. wearing glasses does that. exercising does that. Let's not get too defensive.
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i fear this will eventually be forced on people who dont want it
That's OK. We'll put it in your toothpaste.
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> i fear this will eventually be forced on people who dont want it
Maybe if you're admitted to a psychiatric hospital.
Seems obvious (Score:2)
I woke up this morning and Pakistan was making strong efforts towards world peace. I feel like I'm in an alternate reality.
Had some many years ago (Score:2)
Oh? (Score:2)
Also is it true that it's only good changes? *blinks*
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